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Conserved domains on  [gi|1172323323|ref|WP_080706602|]
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MFS transporter [Bordetella bronchiseptica]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 22-470 2.80e-53

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 183.14  E-value: 2.80e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnafGLGWRLVFLIN 181
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE----LFGWRWIFLIN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 182 VPVGIAALLAGRRalpewrapiatkvdmwgallgavglalilvpvmegrehgwpwwslagpvlallvlgyfvhyeqglvr 261
Cdd:cd17321   157 VPIGLVALLLART------------------------------------------------------------------- 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 262 rggvpmldmglfanrpFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG- 340
Cdd:cd17321   170 ----------------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGp 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 341 RGALLFGVLVFAAGVALSAVTAATQPhhLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVGTS- 419
Cdd:cd17321   234 RLVLVAGLLLTAVGLLLLALLGADSS--VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAl 311

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172323323 420 --------VGVAVVGAVVFAALEAAGRWPAADGAMVYGRALAVAMVYNVAAALASWVLF 470
Cdd:cd17321   312 gvallgalLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 22-470 2.80e-53

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 183.14  E-value: 2.80e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnafGLGWRLVFLIN 181
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE----LFGWRWIFLIN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 182 VPVGIAALLAGRRalpewrapiatkvdmwgallgavglalilvpvmegrehgwpwwslagpvlallvlgyfvhyeqglvr 261
Cdd:cd17321   157 VPIGLVALLLART------------------------------------------------------------------- 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 262 rggvpmldmglfanrpFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG- 340
Cdd:cd17321   170 ----------------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGp 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 341 RGALLFGVLVFAAGVALSAVTAATQPhhLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVGTS- 419
Cdd:cd17321   234 RLVLVAGLLLTAVGLLLLALLGADSS--VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAl 311

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172323323 420 --------VGVAVVGAVVFAALEAAGRWPAADGAMVYGRALAVAMVYNVAAALASWVLF 470
Cdd:cd17321   312 gvallgalLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-419 1.27e-43

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 160.24  E-value: 1.27e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  17 RALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLAS 96
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  97 ALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRL 176
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIEN----YHWRW 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 177 VFLINVPVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALILVPVMEGREHGW--PWWSLAGPVLALLVLGYFVH 254
Cdd:TIGR00711 158 IFLINVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWfdSNEILILSITGLVAIIAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 255 YEQglvrRGGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPR 334
Cdd:TIGR00711 238 WEL----TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 335 LAARYG-RGALLFGVLVFAAGVALSAVTAATQPHHLPLLVASLVLNGAGQGLAIPLAfNAILGAVREEQAGMASGMLSTL 413
Cdd:TIGR00711 314 MGDKIDpRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLT-TIALSGLPPHKIARGSSLSNFT 392


                  ....*.
gi 1172323323 414 QVVGTS 419
Cdd:TIGR00711 393 RQLGGS 398
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-419 6.20e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 125.09  E-value: 6.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  12 RRHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGL 91
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  92 FTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafg 171
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL---- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 172 LGWRLVFLINVPVGIAALLAGRRALPEWRAPiatkvdmwgallgavglalilvpvmegrehgwpwwslagpvlallvlgy 251
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLRLLPESRPA------------------------------------------------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 252 fvhyeqglvRRGGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLV 331
Cdd:COG2814   192 ---------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALL 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 332 GPRLAARYGRGALLFGVLVFAAGVALsavtAATQPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLS 411
Cdd:COG2814   263 AGRLADRFGRRRLLLIGLLLLALGLL----LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338


                  ....*...
gi 1172323323 412 TLQVVGTS 419
Cdd:COG2814   339 SAFFLGGP 346
PRK10504 PRK10504
putative transporter; Provisional
 25-373 2.72e-24

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 105.20  E-value: 2.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  25 GNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVT 104
Cdd:PRK10504   18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 105 PWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNAfglgWRLVFLINVPV 184
Cdd:PRK10504   98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAS----WHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 185 GIAALLAGRRALPEWRAPiATKVDMWGALLGAVGLALILVPVMEGREHGWPWWSLAGPVLA--LLVLGYFVHyeqglVRR 262
Cdd:PRK10504  174 GIIGAIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVgvVALLLYLLH-----ARN 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 263 GGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG-R 341
Cdd:PRK10504  248 NNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGyR 327

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1172323323 342 GALLFGVLVFAAGVALSAVTAATQPHHLPLLV 373
Cdd:PRK10504  328 RVLVATTLGLALVSLLFMLVALLGWYYLLPFV 359
MFS_1 pfam07690
Major Facilitator Superfamily;
22-417 1.05e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.09  E-value: 1.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPS-IQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCG 100
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 101 VAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLI 180
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL----FGWRAAFLI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 181 NVPVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALILVPVMegrehgwpwWSLAGPVLALLVLGYFVHYeqglv 260
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL---------WLLLALLLFGFAFFGLLTY----- 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 261 rrggvpmldmglfanrpfvagigavffffsaissfffalTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG 340
Cdd:pfam07690 223 ---------------------------------------LPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172323323 341 RGALLFGVLVFAAGVALSAVTAATqPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVG 417
Cdd:pfam07690 264 RRRRLLLALLLLILAALGLLLLSL-TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 22-470 2.80e-53

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 183.14  E-value: 2.80e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnafGLGWRLVFLIN 181
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE----LFGWRWIFLIN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 182 VPVGIAALLAGRRalpewrapiatkvdmwgallgavglalilvpvmegrehgwpwwslagpvlallvlgyfvhyeqglvr 261
Cdd:cd17321   157 VPIGLVALLLART------------------------------------------------------------------- 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 262 rggvpmldmglfanrpFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG- 340
Cdd:cd17321   170 ----------------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGp 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 341 RGALLFGVLVFAAGVALSAVTAATQPhhLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVGTS- 419
Cdd:cd17321   234 RLVLVAGLLLTAVGLLLLALLGADSS--VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAl 311

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172323323 420 --------VGVAVVGAVVFAALEAAGRWPAADGAMVYGRALAVAMVYNVAAALASWVLF 470
Cdd:cd17321   312 gvallgalLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-419 1.27e-43

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 160.24  E-value: 1.27e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  17 RALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLAS 96
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  97 ALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRL 176
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIEN----YHWRW 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 177 VFLINVPVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALILVPVMEGREHGW--PWWSLAGPVLALLVLGYFVH 254
Cdd:TIGR00711 158 IFLINVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWfdSNEILILSITGLVAIIAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 255 YEQglvrRGGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPR 334
Cdd:TIGR00711 238 WEL----TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 335 LAARYG-RGALLFGVLVFAAGVALSAVTAATQPHHLPLLVASLVLNGAGQGLAIPLAfNAILGAVREEQAGMASGMLSTL 413
Cdd:TIGR00711 314 MGDKIDpRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLT-TIALSGLPPHKIARGSSLSNFT 392


                  ....*.
gi 1172323323 414 QVVGTS 419
Cdd:TIGR00711 393 RQLGGS 398
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 22-419 5.70e-41

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 150.42  E-value: 5.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnafGLGWRLVFLIN 181
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTD----NLSWRWIFYIN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 182 VPVGIAALLAGrralpewrapiatkvdmwgallgavglalilvpvmegrehgwpwwslagpvlallvlgyfvhyeqglvr 261
Cdd:cd17503   157 LPIGILALLLA--------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 262 rggvPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG- 340
Cdd:cd17503   168 ----PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGp 243

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172323323 341 RGALLFGVLVFAAGVALSAVTAATQPhhLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVGTS 419
Cdd:cd17503   244 RLLLLAGLLLLALGTLLLAFLTPDTS--LWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGS 320
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-419 6.20e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 125.09  E-value: 6.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  12 RRHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGL 91
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  92 FTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafg 171
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL---- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 172 LGWRLVFLINVPVGIAALLAGRRALPEWRAPiatkvdmwgallgavglalilvpvmegrehgwpwwslagpvlallvlgy 251
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLRLLPESRPA------------------------------------------------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 252 fvhyeqglvRRGGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLV 331
Cdd:COG2814   192 ---------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALL 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 332 GPRLAARYGRGALLFGVLVFAAGVALsavtAATQPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLS 411
Cdd:COG2814   263 AGRLADRFGRRRLLLIGLLLLALGLL----LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338


                  ....*...
gi 1172323323 412 TLQVVGTS 419
Cdd:COG2814   339 SAFFLGGP 346
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 13-302 7.59e-31

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 120.69  E-value: 7.59e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  13 RHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLF 92
Cdd:COG0477    10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  93 TLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgL 172
Cdd:COG0477    90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA----L 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 173 GWRLVFLINVPVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALILVPVMEGREHGWPWWSLAGPVLALLVLGYF 252
Cdd:COG0477   166 GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1172323323 253 VHYEQGLVRRGGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLL 302
Cdd:COG0477   246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 22-419 1.18e-28

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 115.74  E-value: 1.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDtDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17502     1 LMLALFLAALDQTIVATALPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnafGLGWRLVFLIN 181
Cdd:cd17502    80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD----HLSWRWCFYIN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 182 VPVGiaallagrralpewrapiatkvdmwgallgavGLALILVPVmegrehgwPWWSLAGPVLALLVLGYFVHYeqglvr 261
Cdd:cd17502   156 LPIG--------------------------------GLALALLRT--------ILLSSIFGFLFGGALFGLIYY------ 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 262 rggvpmldmglfanrpfvagigavffffsaissfffaLTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYGR 341
Cdd:cd17502   190 -------------------------------------LPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGR 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 342 --GALLFGVLVFAAGVALSAVTAATQphHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVGTS 419
Cdd:cd17502   233 ykPLIVIGTILMSVGAGLLTTLTLDT--SKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGT 310
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 35-419 1.25e-27

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 113.44  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  35 IVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARAL 114
Cdd:cd17320    17 MYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 115 QGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLAGRR 194
Cdd:cd17320    97 QGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF----FGWRAIFVFLALLGLLLLLLVLL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 195 ALPEWRAPIATKVDMWGALLGAvglalilvpvmegrehgwpwwslagpvlallvlgyfvhyeqglvrrggvpmldMGLFA 274
Cdd:cd17320   173 FLPETLPEEKRKPLLSSLLRAY-----------------------------------------------------KRVLK 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 275 NRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG-RGALLFGVLVFAA 353
Cdd:cd17320   200 NRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGpRRLLRLGLLLLLA 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172323323 354 GVALSAVTAATQPHHLPLLVASLVLNGAGQGLAIPLAFNAILgAVREEQAGMASGMLSTLQVVGTS 419
Cdd:cd17320   280 AALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL-EPFPHVAGTASALLGFLQFLIGA 344
PRK10504 PRK10504
putative transporter; Provisional
 25-373 2.72e-24

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 105.20  E-value: 2.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  25 GNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVT 104
Cdd:PRK10504   18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 105 PWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNAfglgWRLVFLINVPV 184
Cdd:PRK10504   98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAS----WHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 185 GIAALLAGRRALPEWRAPiATKVDMWGALLGAVGLALILVPVMEGREHGWPWWSLAGPVLA--LLVLGYFVHyeqglVRR 262
Cdd:PRK10504  174 GIIGAIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVgvVALLLYLLH-----ARN 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 263 GGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG-R 341
Cdd:PRK10504  248 NNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGyR 327

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1172323323 342 GALLFGVLVFAAGVALSAVTAATQPHHLPLLV 373
Cdd:PRK10504  328 RVLVATTLGLALVSLLFMLVALLGWYYLLPFV 359
PRK14995 PRK14995
SmvA family efflux MFS transporter;
16-361 2.54e-22

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 99.42  E-value: 2.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  16 WRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAY-GLCLINGArLGDLFGRRRLFLAGMGLFTL 94
Cdd:PRK14995    5 WLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMaGMVLPMGA-LGDRIGFKRLLMLGGTLFGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  95 ASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLF-EGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLG 173
Cdd:PRK14995   84 ASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEH----FY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 174 WRLVFLINVPVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALILVPVMEG-REHGWPWWSLAGPVLALLVLGYF 252
Cdd:PRK14995  160 WGSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTAlKGFLSLWVTSLTLLTGALLLGLF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 253 VHYEqglvRRGGVPMLDMGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAffgASLVG 332
Cdd:PRK14995  240 IRTQ----LAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVA---SGFSG 312

                         330       340
                  ....*....|....*....|....*....
gi 1172323323 333 PRLAARYGRGALLfgvLVFAAGVALSAVT 361
Cdd:PRK14995  313 PIAGILVSRLGLR---LVATGGMALSALS 338
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 22-417 1.06e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 96.49  E-value: 1.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLIN 181
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA----LGYRAPFLVC 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 182 VPVGIAALLAGRRALPEWRAPIATKvdmwgallgavglalilvPVMEGREHGWPWWSLAGPVLALLVLGYFVHYeqglvr 261
Cdd:cd17325   157 AALALLALVLALLLLPEPRPPPNKR------------------AVSAARLRSGLRLLLRDRRLLALFLAIFVLA------ 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 262 rggvpmldmglfanrpfvAGIGAVffffsaissfFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYGR 341
Cdd:cd17325   213 ------------------FAFGAL----------EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR 264

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172323323 342 -GALLFGVLVFAAGVALSAVTAAtqphhLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVG 417
Cdd:cd17325   265 kPLILIGLLLSAVALLLLPLATS-----FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLG 336
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 19-417 3.65e-21

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 94.94  E-value: 3.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  19 LAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASAL 98
Cdd:cd17474     1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  99 CGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafglGWRLVF 178
Cdd:cd17474    81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-----SWRYPF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 179 LINVPVGIAALLAgrralpewrapiatkvdmwgallgavglALILVPVMEGREHGWPWWSLAGPVLAllvlgyfvhyeqg 258
Cdd:cd17474   156 FLLAALIPVAFLA----------------------------ILFLLPEPKEKAKSSSATKLRDLKKA------------- 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 259 lvrrggvpmldmglFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAF-FGASLVGPRLAA 337
Cdd:cd17474   195 --------------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLaLGSLFVGRLLKK 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 338 RYGRGALLFGVLVFAAGVALSAVTAatqpHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVG 417
Cdd:cd17474   261 RFGARRILVIGLLLYALSLLLLGFV----PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 39-419 5.08e-21

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 94.18  E-value: 5.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  39 ALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVG 118
Cdd:cd17504    18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 119 AGVLmPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLAgrralpe 198
Cdd:cd17504    98 GAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQH----LGWRWIFWTAAPVAVLLAAL------- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 199 wrapiatkvdmwgallgavglalilvpvmegrehgwpwwslagpvlallvlgyfvhyeqglvrrggVPMLDMGLFANRPF 278
Cdd:cd17504   166 ------------------------------------------------------------------VPLIDLRLLRRRNV 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 279 VAGIGAVFFFFSAISSFFFALTLLLQ----FGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG-RGALLFGVLVFAA 353
Cdd:cd17504   180 LLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGpRRVLLIGLVISAV 259

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172323323 354 GVALsavtAATQPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVGTS 419
Cdd:cd17504   260 GLLL----LALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSA 321
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-191 4.91e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 91.47  E-value: 4.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  12 RRHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGL 91
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  92 FTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafg 171
Cdd:COG2271    85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA---- 160

                         170       180
                  ....*....|....*....|
gi 1172323323 172 LGWRLVFLINVPVGIAALLA 191
Cdd:COG2271   161 FGWRAAFLILGLPGLLLALL 180
MFS_1 pfam07690
Major Facilitator Superfamily;
22-417 1.05e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.09  E-value: 1.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPS-IQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCG 100
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 101 VAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLI 180
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL----FGWRAAFLI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 181 NVPVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALILVPVMegrehgwpwWSLAGPVLALLVLGYFVHYeqglv 260
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL---------WLLLALLLFGFAFFGLLTY----- 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 261 rrggvpmldmglfanrpfvagigavffffsaissfffalTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG 340
Cdd:pfam07690 223 ---------------------------------------LPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172323323 341 RGALLFGVLVFAAGVALSAVTAATqPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVG 417
Cdd:pfam07690 264 RRRRLLLALLLLILAALGLLLLSL-TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 20-419 3.50e-18

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 85.78  E-value: 3.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  20 AVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALC 99
Cdd:cd17476     1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 100 GVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRR-AFGVMGAVQGVAATVSQLLGGVLITMNafglgwrlvf 178
Cdd:cd17476    81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLA---------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 179 linvpvgiaallagrralpewrapiatkvdmwgallgavglalilvpvmegrehGWPW--WSLAGPVLALLVLGYFvhye 256
Cdd:cd17476   151 ------------------------------------------------------WWPWifWFLAILAAIVAVAAIF---- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 257 qglvrrggvpmldmglFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLA 336
Cdd:cd17476   173 ----------------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLI 236

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 337 ARYGRGALLFGVLVFaagVALSAVTAATQPHH---LPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTL 413
Cdd:cd17476   237 ARLPPSYIMAISMVA---FLVGPILFATMPVHqtyWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTV 313


                  ....*.
gi 1172323323 414 QVVGTS 419
Cdd:cd17476   314 VNYGIS 319
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 19-412 5.20e-18

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 85.32  E-value: 5.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  19 LAVLLTGNFVTILDLFIVNVALPSIQQG-LSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASA 97
Cdd:cd17473     1 LITLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  98 LCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnafgLGWRLV 177
Cdd:cd17473    81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-----IGWRAP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 178 FLINVpVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALILvpvmegrehgwpwwslagPVLALLVLGYFVHYeq 257
Cdd:cd17473   156 FLVYL-LALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVL------------------PIYFLAFLAMLLFY-- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 258 glvrrggvpmldmGLFANRPFvagigavffffsaissfffaltlLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAA 337
Cdd:cd17473   215 -------------VIPIQLPF-----------------------LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172323323 338 RYGRGALLF-GVLVFAAGVALSAVTaatqpHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLST 412
Cdd:cd17473   259 RLGKRRLLAiGFALMALGFLLLALA-----SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 21-216 3.16e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 76.82  E-value: 3.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  21 VLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCG 100
Cdd:cd17324     3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 101 VAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAvqgvAATVSQLLGGVLITMNAFGLGWRLVFLI 180
Cdd:cd17324    83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFS----GLTLGLVLGRPLGGLLGQLLGWRAAFLA 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1172323323 181 NVPVGIAALLAGRRALPEWRAPIATKVDMWGALLGA 216
Cdd:cd17324   159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLL 194
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-417 4.44e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 76.70  E-value: 4.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnAFGLGWRLVFLIN 181
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS--SLGFGWRAVFLIA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 182 VPVGIAALLAGRRALPEWRAPIATKVDMWGALLGAVGLALilvpvmegrehgwpwwslagpvlallvlgyfvhyeqglvr 261
Cdd:cd06174   159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKR---------------------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 262 rggvpmldmgLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYGR 341
Cdd:cd06174   199 ----------VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172323323 342 GALLFGVLVFAAGVALSAVTAATqphHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVG 417
Cdd:cd06174   269 RKPLLLIGLLLMALGLALLLLAP---SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLG 341
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
15-417 8.24e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 76.07  E-value: 8.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  15 PWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTL 94
Cdd:COG2223     3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  95 ASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGW 174
Cdd:COG2223    83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA----FGW 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 175 RLVFLINVPVGIAALLAGRRAL--PEWRAPIATKVDMWGALLgavglalilvpvmegrehgwpwwSLAGPVLALLVLGYF 252
Cdd:COG2223   159 RNAFLILGILLLVVAVLAWLFLrdPPAGAAAAAKASLRDQLE-----------------------ALRDPRFWLLSLLYF 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 253 VHyeqglvrrggvpmldmglfanrpFVAGIGavffffsaissFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVG 332
Cdd:COG2223   216 GT-----------------------FGSFIG-----------FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLG 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 333 PRLAARYGRGALLFGVLvfaAGVALSAVTAATQPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLST 412
Cdd:COG2223   262 GWLSDRIGGRRVLLIVF---ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGA 338


                  ....*
gi 1172323323 413 LQVVG 417
Cdd:COG2223   339 AGGLG 343
2_A_01_02 TIGR00880
Multidrug resistance protein;
56-198 1.46e-14

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 70.76  E-value: 1.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  56 LVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFE 135
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172323323 136 GEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLAGRRALPE 198
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQF----LGWRAPFLFLAILALAAFILLAFLLPE 140
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 56-422 2.36e-14

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 74.97  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  56 LVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAG--VLMPQVLASirvL 133
Cdd:cd06179    36 WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGtqGLGAAVASE---L 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 134 FEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNAfgLGWRLVFLINVPVGIAALLAG---------RRALPEWRAPIA 204
Cdd:cd06179   113 VPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANA--AGWRWIFYINAIFNALALILLfffyhppprPQLHGSSTRQKL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 205 TKVDMWGALLGAVGLALILVPVMEGrehGWPWWSLAGPVLALLVLGY-----FVHYEqgLVRRGGVPMLDMGLFANRPFV 279
Cdd:cd06179   191 KRLDWVGLFLLIAGLVLFLLGLSWG---GNPYPWSSAHVIAPLVIGGvlliaFGLYE--WKGTKDGLLPPRLLFRGRNFA 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 280 AGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTP-SALAFFGASLVGP-RLAARYGRGALLFGVLVFAAGVAL 357
Cdd:cd06179   266 LILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPfGLGTLFGAILAGLlLTKIKHIKWQLVAGFVLFTAFLAL 345

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172323323 358 savTAATQPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVGTSVGV 422
Cdd:cd06179   346 ---LALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGT 407
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
11-412 1.82e-13

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 71.81  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  11 ERRHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMG 90
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  91 LFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLfEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNaF 170
Cdd:COG0738    82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLG-L 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 171 GLGWRLVFLIN-VPVGIAALLAGRRALPEWRAPIATKVDMWGALLgavglalilvpvmegrehgwpwwslagpvlallvl 249
Cdd:COG0738   160 SLSWHLPYLILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK----------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 250 gyfvhyeqglvrrggvpmldmGLFANRPFVAGIGAVFFFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGAS 329
Cdd:COG0738   205 ---------------------SLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 330 LVGPRLAARYGRGALLFGVLVFAAGVALSAVTAatqpHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGM 409
Cdd:COG0738   264 FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLA----PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAV 339


                  ...
gi 1172323323 410 LST 412
Cdd:COG0738   340 LIM 342
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 19-194 5.50e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 69.94  E-value: 5.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  19 LAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQ--LVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLAS 96
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  97 ALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNAFGLGWRL 176
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160

                         170
                  ....*....|....*...
gi 1172323323 177 VFLINVPVGIAALLAGRR 194
Cdd:cd17316   161 LFLIGALPALLALLLRRR 178
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 16-192 5.92e-13

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 69.91  E-value: 5.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  16 WRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLA 95
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  96 SALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWR 175
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL----FGWR 157

                         170
                  ....*....|....*..
gi 1172323323 176 LVFLInvpVGIAALLAG 192
Cdd:cd17319   158 WAFII---EGLLGLLLA 171
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 19-190 7.79e-13

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 69.96  E-value: 7.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  19 LAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASAL 98
Cdd:cd17328     1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  99 CGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVlitMNAFGLGWRLVF 178
Cdd:cd17328    81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGL---VAQATGGWRWAF 157

                         170
                  ....*....|..
gi 1172323323 179 LINVPVGIAALL 190
Cdd:cd17328   158 RVTGVLGVLLAI 169
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 39-191 6.78e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 66.83  E-value: 6.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  39 ALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVG 118
Cdd:cd17323    21 ALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172323323 119 AGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLitmnAFGLGWRLVFLINVPVGIAALLA 191
Cdd:cd17323   101 GSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFI----TQSLGWRWIFWFLAIISGFCLIL 169
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 39-204 3.34e-11

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 64.71  E-value: 3.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  39 ALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVG 118
Cdd:TIGR00710  27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 119 AGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLAGRRALPE 198
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVW----LSWHAIFAFLSLAGILLSALIFFILPE 182


                  ....*.
gi 1172323323 199 WRAPIA 204
Cdd:TIGR00710 183 TLPYEA 188
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 12-198 1.88e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 62.37  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  12 RRHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGL 91
Cdd:TIGR00895  12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  92 FTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafg 171
Cdd:TIGR00895  92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV---- 167

                         170       180
                  ....*....|....*....|....*..
gi 1172323323 172 LGWRLVFLINVPVGIAALLAGRRALPE 198
Cdd:TIGR00895 168 FGWRSLFYVGGIAPLLLLLLLMRFLPE 194
emrD PRK11652
multidrug transporter EmrD;
39-200 1.21e-09

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 59.92  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  39 ALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVG 118
Cdd:PRK11652   30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 119 AGVLMPQVLASIRVLFEGEARRRAFGV--MGAVqgVAATVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLAGRRAL 196
Cdd:PRK11652  110 TGVGGVMARTLPRDLYEGTQLRHANSLlnMGIL--VSPLLAPLIGGLLTTL----FGWRACYLFLLLLGAGVTFSMARWM 183


                  ....
gi 1172323323 197 PEWR 200
Cdd:PRK11652  184 PETR 187
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 75-198 2.16e-09

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 59.15  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  75 LGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGA--GVLMpqvlASIRVLFEGEARRRAFGVMGAVQGV 152
Cdd:cd17472    55 LSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAisSVVM----ALLADLTREENRTKAMALIGASIGI 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1172323323 153 AATVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLAGRRALPE 198
Cdd:cd17472   131 AFAISMVLGPLLAAH----LGVSGLFLITAILSLVSLLILLFFVPD 172
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 30-198 5.05e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 55.00  E-value: 5.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  30 ILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLI 109
Cdd:cd17371    12 GFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 110 AARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNAFGLGWRLVFLINV-PVGIAA 188
Cdd:cd17371    92 ILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGAlPALLVL 171

                         170
                  ....*....|
gi 1172323323 189 LLagRRALPE 198
Cdd:cd17371   172 FI--RRFVKE 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 49-191 3.13e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.19  E-value: 3.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  49 ATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLA 128
Cdd:cd17325   232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172323323 129 SIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLA 191
Cdd:cd17325   312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA----FGFATPFLAAAALLLLAAVL 370
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 19-209 6.00e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 51.46  E-value: 6.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  19 LAVLLTGNFVTILDLFIV---NVALPSIQQGLSATDTDLqlVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLA 95
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVwpfMAIYLHQQLGLSASIVGL--VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  96 SALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLitmnaFGLGWR 175
Cdd:cd17329    79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-----LLYSFR 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1172323323 176 LVFLINVPVGIAALLAGRRALPEWRAPIATKVDM 209
Cdd:cd17329   154 LLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKT 187
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 31-180 7.65e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.05  E-value: 7.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  31 LDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIA 110
Cdd:cd17365    13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 111 ARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnafGLGWRLVFLI 180
Cdd:cd17365    93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIP----AFGWRSVFLL 158
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
38-182 7.73e-07

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 51.18  E-value: 7.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  38 VALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGV 117
Cdd:PRK10473   24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172323323 118 GAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLG----------GVLITMNAFGLgwrLVFLINV 182
Cdd:PRK10473  104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGhlimlkfpwqSLFYTMAAMGI---LVLLLSL 175
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 74-197 2.65e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.50  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  74 RLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLmPQVLASIRVLFEGEARRRAFGVMGAVQGVA 153
Cdd:cd17330    56 RLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLG 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1172323323 154 ATVSQLLGGVLITMNafglGWRLVFLINVPVGIAALLAGRRALP 197
Cdd:cd17330   135 FILGPALGGFLSTPY----GYALPFLVAAALALLNLVLVLFFLP 174
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
211-394 5.08e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 5.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 211 GALLGAVGLALILVPVMEGREHGWPWWSLAGPVLALLVLGYFVHY--EQGLVRRGGVPMLDM--GLFANRPFVAGIGAVF 286
Cdd:COG2211   159 GGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGtkERPVPEEEKVSLKESlkALLKNRPFLLLLLAYL 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 287 FFFSAISSFFFALTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG-RGALLFGVLVFAAGvalSAVTAATQ 365
Cdd:COG2211   239 LFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGkKKAFIIGLLLAALG---LLLLFFLG 315

                         170       180
                  ....*....|....*....|....*....
gi 1172323323 366 PHHLPLLVASLVLNGAGQGLAIPLAFNAI 394
Cdd:COG2211   316 PGNLWLLLVLAALAGIGLGAILVLPWAML 344
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 25-201 5.74e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 48.34  E-value: 5.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  25 GNFVTILDLFIVNVALPSIQQGL-SATDTDLQLVVVAYALAYGL--CLINGArLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17315     5 GGLLFGYDLGVINGALLYIAKDLgFGLSTSLQGLVVSSLLLGAAigSLFGGP-LADRFGRRKSLLIAAVLYVIGALLSAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGvlmpqvLASIRV-LFEGE---ARRRafGVMGAVQGVAATVSQLLGGV--LITMNAFGLGWR 175
Cdd:cd17315    84 APNVWVLIVGRFLLGLGVG------LASVLVpLYISEiapAKIR--GALGTLNQLMITFGILLAYLlgLALSLSPPGWWR 155

                         170       180
                  ....*....|....*....|....*.
gi 1172323323 176 LVFLINVPVGIaALLAGRRALPEWRA 201
Cdd:cd17315   156 LMFALAAVPAL-LQLLLMFFLPESRA 180
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 74-180 6.34e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 48.41  E-value: 6.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  74 RLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVA 153
Cdd:cd17391   262 KLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLG 341

                          90       100
                  ....*....|....*....|....*..
gi 1172323323 154 ATVSQLLGGVLitmnAFGLGWRLVFLI 180
Cdd:cd17391   342 NVAGPLLGSAI----AAHFGYRAVFVV 364
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 27-191 7.43e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.92  E-value: 7.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  27 FVTILDLFIVNVALPSIQ-QGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTP 105
Cdd:cd17370   208 AVALFALGNFSFAFLILRaQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSL 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 106 WQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgLGWRLVFLINVPVG 185
Cdd:cd17370   288 WLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDL----ISPSAAFLFSAVLA 363


                  ....*.
gi 1172323323 186 IAALLA 191
Cdd:cd17370   364 LIALLL 369
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
39-191 8.67e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 47.99  E-value: 8.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  39 ALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVG 118
Cdd:PRK11102   13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172323323 119 AGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLitmnAFGLGWRLVFLInvpVGIAALLA 191
Cdd:PRK11102   93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWL----LVWFSWHAIFWV---LALAAILA 158
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 37-193 9.26e-06

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 47.76  E-value: 9.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  37 NVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQG 116
Cdd:TIGR00881  15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 117 VGAGVLMPQVLASIRVLFEgearRRAFGVMGAVQGVAATVS-QLLGGVLITMNAFGLGWRLVF----LINVPVGIAALLA 191
Cdd:TIGR00881  95 IFQGMGWPPCGRTVTKWFS----RSERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFivpgIIAIIVSLICFLL 170


                  ..
gi 1172323323 192 GR 193
Cdd:TIGR00881 171 LR 172
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 22-417 1.08e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.59  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGV 101
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 102 AVTPWQLIAARALQGVGAGVLmPQVLASIRVLFEGEARR-RAFGVMGAVQGVAATVSQLLGGVLITMNAFGlgwrlvFLI 180
Cdd:cd17489    81 ATSVALLLVLRLIHGIGWGAF-TTAAATLVADIIPPSRRgEGIGYYGLATTLAMALGPALGLFLYQHLGFA------VLF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 181 NVPVGIAALlagrralpewrapiatkvdmwgallgavglALILVPVMEGREHgwpwwslAGPVLALLVLGYFVHYEQGLV 260
Cdd:cd17489   154 IVAAVLALL------------------------------ALLLVFLVKDPPP-------VAAEEAEAGTRAFRRLVEKKV 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 261 RRGGVPMLDMGLfanrpfvaGIGAVffffsaissfffaLTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYG 340
Cdd:cd17489   197 LPPALILFLASI--------AYGAI-------------STFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKG 255

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172323323 341 RgallFGVLVFAAGVALSAVTAATQPHHLPLLVASLVLNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVG 417
Cdd:cd17489   256 P----KTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLG 328
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 2-192 1.95e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323   2 TDAMPPPNVERRHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQ-LVVVAYALAYGLCLINGARLGDLFG 80
Cdd:cd17473   182 SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLG 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  81 RRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLL 160
Cdd:cd17473   262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1172323323 161 GGVLITMNAFGLG-WRLVFLINVPVGIAALLAG 192
Cdd:cd17473   342 LGPLVNLTGGLSGaFLILGVLALVLAIVLLLLR 374
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 37-187 2.03e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 46.50  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  37 NVALPSIQQGLSATDTDLQLVVVAYALAYGLC-LINGArLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQ 115
Cdd:cd17312    23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGkFISGF-LSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172323323 116 GVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAvqgvAATVSQLLGGVLITMNAFGLGWRLVFLINVPVGIA 187
Cdd:cd17312   102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWST----SHNFGGILAPILAASLASYYGWRAAFLVPGIVGLV 169
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 19-191 2.75e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 46.16  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  19 LAVLLTGNFVTILdlfivnvaLPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASAL 98
Cdd:cd17333     6 FSNGLTDALLGIL--------GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  99 CGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEgEARRRAFGVMGAVQGVAATVSQLLGGVLIT-MNAFGLGWRLV 177
Cdd:cd17333    78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLII 156

                         170
                  ....*....|....
gi 1172323323 178 FLINVPVGIAALLA 191
Cdd:cd17333   157 GLIYLLLAILILLT 170
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-202 4.87e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.63  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323   2 TDAMPPPNVERRHPWRALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGR 81
Cdd:COG2807     3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  82 RRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFeGEARRRAFGVMGAVQGVAATVSQLLG 161
Cdd:COG2807    83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLT 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1172323323 162 GVLITMnafgLGWRLVFLINVPVGIAALLAGRRALPEWRAP 202
Cdd:COG2807   162 VPLAAA----LGWRGALAVWALLALLALLLWLPLLRRRPAA 198
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 31-207 7.25e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.95  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  31 LDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIA 110
Cdd:PRK11551   29 LDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 111 ARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVM------GAVqgVAATVSQLLGGvlitmnafGLGWRLVFLIN--V 182
Cdd:PRK11551  109 ARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMycgvpfGGA--LASVIGVLAAG--------DAAWRHIFYVGgvG 178

                         170       180
                  ....*....|....*....|....*
gi 1172323323 183 PVGIAALLAgrRALPEWRAPIATKV 207
Cdd:PRK11551  179 PLLLVPLLM--RWLPESRAFAQAAG 201
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 20-180 3.15e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 42.93  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  20 AVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALc 99
Cdd:cd17380     2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 100 gvavTPWQ-------LIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMnafgL 172
Cdd:cd17380    81 ----TPLLaysslplLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEY----Y 152


                  ....*...
gi 1172323323 173 GWRLVFLI 180
Cdd:cd17380   153 GWPSVFYF 160
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 72-121 3.39e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 42.64  E-value: 3.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1172323323  72 GARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGV 121
Cdd:cd17360    55 GGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGI 104
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 18-202 5.56e-04

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 42.43  E-value: 5.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  18 ALAVLLTGNFVTILDLFIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASA 97
Cdd:pfam05977  11 VFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVST 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  98 LCGVA-----VTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITmnAFGL 172
Cdd:pfam05977  91 LLTLLaglglLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLA--AFGP 168

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1172323323 173 GWrlVFLINVP---VGIAALLAGRRALPEWRAP 202
Cdd:pfam05977 169 AF--TFALNALsyfAVIAALWRWKRAAPASPLP 199
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 59-191 8.81e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.37  E-value: 8.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  59 VAYALAYGLCLINGaRLGDLFGRRRLF-LAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGE 137
Cdd:cd17370    42 LAEALGSLLRLFSG-YLSDRTGKRKPLvILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPS 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1172323323 138 ARRRAFGVMGAVQGVAATVSQLLGGVLITMNAFGLgwRLVFLINVPVGIAALLA 191
Cdd:cd17370   121 GRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNY--RTIFLLAAIPALLALLI 172
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 75-190 1.20e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.05  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  75 LGDLFGRRRLFL-AGMGLFTLASALCGVAVTPWQLIAARALQGVGAG--VLMPQVLASirvLFEGEARRRAFGVMGAVQG 151
Cdd:cd17490    54 LSDRIGKRKLFIiIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAtwVSFTVLYAS---YFPPDEAAKAMGLINLVNN 130

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1172323323 152 VAATVSQLLGGVLitmnAFGLGWRLVFLINVPVGIAALL 190
Cdd:cd17490   131 LGQLIAFLIGGLI----AEHFGMRAPFLLAALAGVLGFI 165
Sugar_tr pfam00083
Sugar (and other) transporter;
25-198 1.46e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.10  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  25 GNFVTILDLFIVNVALPSIQQGlsATDTDLQLVVVAYALAYGL--CLINGaRLGDLFGRRRLFLAGMGLFTLASALCGVA 102
Cdd:pfam00083  20 GAFLTLIDFFKNFGLSKSVSSL--AALSVLSGLIVSIFSVGCFigSLFAG-KLGDRFGRKKSLLIANVLFVIGAVLQGAA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 103 V---TPWQLIAARALQGVGAGVLmpQVLASirvLFEGE-ARRRAFGVMGAVQGVAATVSQLLG---GVLITMNAFGLGWR 175
Cdd:pfam00083  97 KgkwSVYQLIVGRVLVGIGVGGA--SVLAP---MYISEiAPKKLRGALGSLYQLAITFGILLAyifGLGLNKTSNSDGWR 171

                         170       180
                  ....*....|....*....|...
gi 1172323323 176 LVFLINVPVGIaALLAGRRALPE 198
Cdd:pfam00083 172 IPLGLQLVPAL-LLIIGLLFLPE 193
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 75-191 1.60e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 40.71  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  75 LGDLFGRRRLFLAGMGLFTLASAL---CGVAVTPWQLIAARALQGVGAGVLMpqvlaSIRVLFEGEARRRAF-GVMGAVQ 150
Cdd:cd17357    72 LANRFGRKNGLLISNALLVVSSLLmflSKSAKSPELLIFGRFLVGIACGLST-----GFVPMYLQEISPSELrGALGSLT 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1172323323 151 GVAATVSQLLGGVLITMNAFGL--GWRLVFLINVPVGIAALLA 191
Cdd:cd17357   147 QIGVTLGILLGQVFGLPSVLGTetLWPYLLFFPGIPALLQLAA 189
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 39-238 1.81e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 40.81  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  39 ALPSIQQGLSATDTDlQLVVVAYALAYGLCLINGARLGDLFGRRRlFLAGMGLFTLASALCGVAVTPWQ-LIAARALQGV 117
Cdd:pfam06609  66 ALPNILQDIGQSENQ-GLFSTLWTMGQAVSILMMGRLTDRFGRRP-FVIATHIIGLVGAIVGCTANKFNtLLAAMTLLGV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 118 GAGVlmpqvlASIRVLFEGEARRRAFGVMGAVQGVAATV-SQLLGGVLITMNAFGLGWRLVFLINVPVGIAAL------- 189
Cdd:pfam06609 144 AAGP------AGASPLFIGELMSNKTKFLGLLIVSAPTIaMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVlliiiwy 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1172323323 190 -------LAGRRAlpEWRAPIAtKVDMWGALLGAVGLALILVPVMEGREHGWPWWS 238
Cdd:pfam06609 218 hppsfaqLHGKKA--RKRDELA-KLDWIGIFLVIAGTSLFLLGVSWGGKPNNPWNS 270
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
56-195 2.39e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.24  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  56 LVVVAYALAYGLCLINGARLGDLFGRRR--LFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVL 133
Cdd:COG2271   220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172323323 134 FEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNAFGLGWRLVFLINVPVGIAALLAGRRA 195
Cdd:COG2271   300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
17-165 2.91e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  17 RALAVLLTGNFVTILDLFIVNVALP-SIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLA 95
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172323323  96 SALCGVAV--TPWQLIAARALQGVGAG---VLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLI 165
Cdd:COG2211   308 LLLLFFLGpgNLWLLLVLAALAGIGLGailVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALA 382
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 41-194 3.00e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  41 PSIQQGLSATDTDLQLVVVAYALAYGL-CLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGA 119
Cdd:cd17490   219 PLIAKQLGASSFQLGLLSIIYLLPNALaSLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGT 298

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172323323 120 GVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLitMNAFGLGWrlVFLINVPVGIAALLAGRR 194
Cdd:cd17490   299 GILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGII--SEAFGLQT--GFFVIGVIALLAAILSLA 369
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 299-417 3.38e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 299 LTLLLQFGLGMAPLAAGAVFTPSALAFFGASLVGPRLAARYGR-GALLFGVLVFAAGVALSAVTaatqpHHLPLLVASLV 377
Cdd:cd17329    22 MAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRkPVMLAGLLLRALGFALLGFA-----HSPWLFAIALV 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1172323323 378 LNGAGQGLAIPLAFNAILGAVREEQAGMASGMLSTLQVVG 417
Cdd:cd17329    97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLG 136
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
75-119 5.29e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 39.11  E-value: 5.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1172323323  75 LGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGA 119
Cdd:PRK11043   64 LSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGV 108
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 56-164 5.70e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 38.77  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  56 LVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVlMPQVLASIRVLFE 135
Cdd:cd17388    42 VLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGAT-GAVAAAYIADVTP 120

                          90       100
                  ....*....|....*....|....*....
gi 1172323323 136 GEARRRAFGVMGAVQGVAATVSQLLGGVL 164
Cdd:cd17388   121 PEQRARNFGLLGAAFGLGFIAGPALGGLL 149
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
75-198 6.20e-03

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 38.77  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  75 LGDLFGRRRLFLAGMGLFTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAA 154
Cdd:PRK15402   71 LSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAP 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1172323323 155 TVSQLLGGVLITMnafgLGWRLVFLINVPVGIAALLAGRRALPE 198
Cdd:PRK15402  151 LLGPLVGAALIHV----LPWRGMFVLFAALAALSFFGLWRAMPE 190
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
22-200 9.80e-03

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 38.12  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  22 LLTGNFVTILDLFIVnVALPSI----QQGLSAtdtdlqlVVVAYALAY------GLCLINGArLGDLFGRRRLFLAGMGL 91
Cdd:PRK11646   15 LLIDNMLVVLGFFVV-FPLISIrfvdQLGWAA-------VMVGIALGLrqfiqqGLGIFGGA-IADRFGAKPMIVTGMLM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  92 FTLASALCGVAVTPWQLIAARALQGVGAGVLMPQVLASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNafg 171
Cdd:PRK11646   86 RAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYD--- 162

                         170       180
                  ....*....|....*....|....*....
gi 1172323323 172 lgWRLVFLINVPVGIAALLAGRRALPEWR 200
Cdd:PRK11646  163 --FRLVCATGAVLFVLAAAFNAWLLPAYK 189
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 34-191 9.95e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 38.00  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323  34 FIVNVALPSIQQGLSATDTDLQLVVVAYALAYGLCLINGARLGDLFGRRRLFLAGMGLFTLASALCGVAVTP-WQLIAAR 112
Cdd:cd17341    16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSyWGLLVLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172323323 113 ALQGVGAGVLMPQVlASIRVLFEGEARRRAFGVMGAVQGVAATVSQLLGGVLITMNAF---GLGWRLVFLINVPVGIAAL 189
Cdd:cd17341    96 FLLGFAGANFASGQ-PWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFdggFVGWRNAFFVPGILLAIAA 174


                  ..
gi 1172323323 190 LA 191
Cdd:cd17341   175 VL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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