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Conserved domains on  [gi|1173271762|ref|WP_081131127|]
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MULTISPECIES: class II fructose-bisphosphate aldolase [Enterococcus]

Protein Classification

class II fructose-bisphosphate aldolase( domain architecture ID 10785082)

class II fructose-1,6-bisphosphate (FBP) aldolase catalyzes the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate

CATH:  3.20.20.70
EC:  4.1.2.13
Gene Ontology:  GO:0004332|GO:0006096|GO:0008270|GO:0030388
PubMed:  12206759|2199259|1412694
SCOP:  4003234

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-277 2.98e-131

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439961  Cd Length: 283  Bit Score: 373.66  E-value: 2.98e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MYTTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:COG0191     1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDAL 160
Cdd:COG0191    81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:COG0191   161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:COG0191   241 AVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLF 277
 
Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-277 2.98e-131

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 373.66  E-value: 2.98e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MYTTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:COG0191     1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDAL 160
Cdd:COG0191    81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:COG0191   161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:COG0191   241 AVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLF 277
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-277 2.20e-126

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 361.07  E-value: 2.20e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   5 LKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHLDHAR 84
Cdd:cd00947     1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  85 DFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDdkVYTKPEDALVFVK 164
Cdd:cd00947    81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDEG--LLTDPEEAEEFVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 165 ETGVDALAIAIGTNHGQFKSKTEV-NIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKAAK 243
Cdd:cd00947   159 ETGVDALAVAIGTSHGAYKGGEPKlDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALR 238

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1173271762 244 TTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:cd00947   239 EYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELF 272
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-277 2.58e-121

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 348.25  E-value: 2.58e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   3 TTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKY--IGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyaGGAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVaeDDKVYTKPEDAL 160
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVV--DEKLYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKttfgETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:pfam01116 239 AVR----EYPPNKDPRKYLRPAEEAMKEVVKEKIRLF 271
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 4-277 2.28e-93

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 277.32  E-value: 2.28e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   4 TLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIG-MNVLVHVMKAIAEE-EMVDAVLHLD 81
Cdd:TIGR01859   3 NGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgYKMAVAMVKTLIERmSIVPVALHLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  82 HARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEgiHVAEDDKVYTKPEDALV 161
Cdd:TIGR01859  83 HGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIED--GVDEKEAELADPDEAEQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 162 FVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKA 241
Cdd:TIGR01859 161 FVKETGVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFTAA 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1173271762 242 AKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:TIGR01859 241 IRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLF 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-277 2.61e-90

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 269.67  E-value: 2.61e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MYTTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:PRK12857    2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALHL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDAL 160
Cdd:PRK12857   82 DHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAAMTDPEEAR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:PRK12857  162 RFVEETGVDALAIAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIREAFVA 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:PRK12857  242 RLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLF 278
 
Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-277 2.98e-131

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 373.66  E-value: 2.98e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MYTTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:COG0191     1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDAL 160
Cdd:COG0191    81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:COG0191   161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:COG0191   241 AVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLF 277
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-277 2.20e-126

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 361.07  E-value: 2.20e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   5 LKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHLDHAR 84
Cdd:cd00947     1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  85 DFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDdkVYTKPEDALVFVK 164
Cdd:cd00947    81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDEG--LLTDPEEAEEFVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 165 ETGVDALAIAIGTNHGQFKSKTEV-NIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKAAK 243
Cdd:cd00947   159 ETGVDALAVAIGTSHGAYKGGEPKlDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALR 238

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1173271762 244 TTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:cd00947   239 EYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELF 272
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-277 2.58e-121

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 348.25  E-value: 2.58e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   3 TTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKY--IGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyaGGAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVaeDDKVYTKPEDAL 160
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVV--DEKLYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKttfgETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:pfam01116 239 AVR----EYPPNKDPRKYLRPAEEAMKEVVKEKIRLF 271
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 4-277 2.28e-93

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 277.32  E-value: 2.28e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   4 TLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIG-MNVLVHVMKAIAEE-EMVDAVLHLD 81
Cdd:TIGR01859   3 NGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgYKMAVAMVKTLIERmSIVPVALHLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  82 HARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEgiHVAEDDKVYTKPEDALV 161
Cdd:TIGR01859  83 HGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIED--GVDEKEAELADPDEAEQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 162 FVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKA 241
Cdd:TIGR01859 161 FVKETGVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFTAA 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1173271762 242 AKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:TIGR01859 241 IRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLF 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-277 2.61e-90

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 269.67  E-value: 2.61e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MYTTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:PRK12857    2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALHL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDAL 160
Cdd:PRK12857   82 DHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAAMTDPEEAR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:PRK12857  162 RFVEETGVDALAIAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIREAFVA 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:PRK12857  242 RLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLF 278
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 5-277 7.30e-88

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 263.80  E-value: 7.30e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   5 LKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYI-GMNVLVHVMKAIAEEEM--VDAVLHLD 81
Cdd:TIGR00167   6 VKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIaGLGAISAMVKAMSEAYPygVPVALHLD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  82 HARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDALV 161
Cdd:TIGR00167  86 HGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESALYTDPEEAKE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 162 FVKETGVDALAIAIGTNHGQFKSK-TEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:TIGR00167 166 FVKLTGVDSLAAAIGNVHGVYKGEpKGLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQIAFAA 245

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:TIGR00167 246 AVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLF 282
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-278 9.68e-88

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 263.09  E-value: 9.68e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MYTTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHL 80
Cdd:PRK12737    2 YIISTKNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKYNIPLALHL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDAL 160
Cdd:PRK12737   82 DHHEDLDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDLVVDEKDAMYTNPDAAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:PRK12737  162 EFVERTGIDSLAVAIGTAHGLYKGEPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKIAFSD 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLFM 278
Cdd:PRK12737  242 AVKKYFYENPKANDPRKYMTPGKAAMKEVVREKIKVCG 279
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-274 3.65e-87

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 261.98  E-value: 3.65e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MY-TTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLH 79
Cdd:PRK09195    1 MYlVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  80 LDHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDA 159
Cdd:PRK09195   81 LDHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADALYTDPAQA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 160 LVFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWT 239
Cdd:PRK09195  161 REFVEATGIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFS 240

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1173271762 240 KAAKTTFGETEINKSLRHNVIPANEAIKETVKHKI 274
Cdd:PRK09195  241 QALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVI 275
PRK08185 PRK08185
hypothetical protein; Provisional
 5-277 1.20e-77

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 237.32  E-value: 1.20e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   5 LKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVmKAIAEEEMVDAVLHLDHAR 84
Cdd:PRK08185    1 MKELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLGDNFFAYV-RERAKRSPVPFVIHLDHGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  85 DFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDALVFVK 164
Cdd:PRK08185   80 TIEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIIYTDPEQAEDFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 165 ETGVDALAIAIGTNHGQFKS--KTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKAA 242
Cdd:PRK08185  160 RTGVDTLAVAIGTAHGIYPKdkKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKV 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1173271762 243 KTTFGEteiNKSLRH-NVI--PANEAIKETVKHKIGLF 277
Cdd:PRK08185  240 REILSD---NPSLYEpNQIypSAIEAAKEVVRHKMDLF 274
gatY PRK07998
class II aldolase;
6-286 1.64e-75

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 231.96  E-value: 1.64e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   6 KEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHLDHARD 85
Cdd:PRK07998    7 RILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVPVSLHLDHGKT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  86 FDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGiHVAEDDKvYTKPEDALVFVKE 165
Cdd:PRK07998   87 FEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAILGKEDD-HVSEADC-KTEPEKVKDFVER 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 166 TGVDALAIAIGTNHGQFKSKtEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELlvqwTKAAKTT 245
Cdd:PRK07998  165 TGCDMLAVSIGNVHGLEDIP-RIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDL----RKAFITT 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1173271762 246 FGETEINKSLRHNVI----PANEAIKETVKHKIgLFMNVESPTSL 286
Cdd:PRK07998  240 VGKAYVNNHNEANLArvmaKAKQAVEEDVYSKI-KMMNSNHRLVR 283
PRK06806 PRK06806
class II aldolase;
5-277 8.16e-75

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 230.03  E-value: 8.16e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   5 LKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHLDHAR 84
Cdd:PRK06806    6 MKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKVPVAVHFDHGM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  85 DFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGihvAEDDKV-YTKPEDALVFV 163
Cdd:PRK06806   86 TFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDG---SEDIEMlLTSTTEAKRFA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 164 KETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKAAK 243
Cdd:PRK06806  163 EETDVDALAVAIGNAHGMYNGDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVATATFNSVITAVN 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1173271762 244 TTFGETEINK--SLRHNVIpanEAIKETVKHKIGLF 277
Cdd:PRK06806  243 NLVLNTPYSDyfTYHQDVI---KAAYENVKKHMQIF 275
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 4-277 4.34e-72

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 223.33  E-value: 4.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   4 TLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYI-GMNVLVHVMKAIAEEE--MVDAVLHL 80
Cdd:PRK08610    5 SMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMsGFYTVVKMVEGLMHDLniTIPVAIHL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEgiHVAEDDKVYTKPEDAL 160
Cdd:PRK08610   85 DHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQED--DVVADGIIYADPKECQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:PRK08610  163 ELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIASAK 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:PRK08610  243 AVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEF 279
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 4-277 1.00e-66

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 209.91  E-value: 1.00e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   4 TLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYI-GMNVLVHVMKAIAEEE--MVDAVLHL 80
Cdd:PRK07709    5 SMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMtGFKTVVAMVKALIEEMniTVPVAIHL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIhVAEdDKVYTKPEDAL 160
Cdd:PRK07709   85 DHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDV-IAE-GVIYADPAECK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:PRK07709  163 HLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEFTK 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1173271762 241 AAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:PRK07709  243 AVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREF 279
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
6-274 1.92e-66

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 209.12  E-value: 1.92e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   6 KEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHLDHARD 85
Cdd:PRK12738    7 KYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHES 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  86 FDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDALVFVKE 165
Cdd:PRK12738   87 LDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVEL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 166 TGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKAAKTT 245
Cdd:PRK12738  167 TGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAW 246

                         250       260
                  ....*....|....*....|....*....
gi 1173271762 246 FGETEINKSLRHNVIPANEAIKETVKHKI 274
Cdd:PRK12738  247 FAENPQGNDPRYYMRVGMDAMKEVVRNKI 275
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
1-277 1.95e-66

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 209.83  E-value: 1.95e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   1 MYTTLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEE-EMVDAVLH 79
Cdd:PRK05835    1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERyPHIPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  80 LDHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDA 159
Cdd:PRK05835   81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 160 LVFVKETGVDALAIAIGTNHGQFKSKTE--VNIPLLKEIDARVDVPLVIHGGTGVKEEDYPAL----------------- 220
Cdd:PRK05835  161 EQFVKESQVDYLAPAIGTSHGAFKFKGEpkLDFERLQEVKRLTNIPLVLHGASAIPDDVRKSYldaggdlkgskgvpfef 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1173271762 221 ----INNGIRKFNVGTELLVQWTKAAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:PRK05835  241 lqesVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLL 301
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
4-277 6.00e-61

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 194.97  E-value: 6.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   4 TLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEMVDAVLHLDHA 83
Cdd:PRK06801    5 SLANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLNLDHG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  84 RDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEG-IHVAEDDKVYTKPEDALVF 162
Cdd:PRK06801   85 LHFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGaLYGEADSAKFTDPQLARDF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 163 VKETGVDALAIAIGTNHGQFKSKTEVNIPLLKEIDARVDVPLVIHGGTGVKEEDYPALINNGIRKFNVgtellvqWTKAA 242
Cdd:PRK06801  165 VDRTGIDALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINF-------YTGMS 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1173271762 243 KTTFGETEINKSLRHN--------VIPANEAIKETVKHKIGLF 277
Cdd:PRK06801  238 QAALAAVEQRMTHRHAiydefaelLLGIEEAISDTVAQQMRIF 280
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
6-274 2.24e-60

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 194.56  E-value: 2.24e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   6 KEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAE--EEM---VDAVLHL 80
Cdd:PRK07084   13 REMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANATLLRYMAQGAVEyaKELgcpIPIVLHL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  81 DHARDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEgiHVAEDDKVYTKPEDAL 160
Cdd:PRK07084   93 DHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVED--EVSAEHHTYTQPEEVE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 161 VFVKETGVDALAIAIGTNHGQFKSKTEVNIP-----LLKEIDARV-DVPLVIHGGTGVKEEdYPALINN---------GI 225
Cdd:PRK07084  171 DFVKKTGVDSLAISIGTSHGAYKFKPGQCPPplrfdILEEIEKRIpGFPIVLHGSSSVPQE-YVKTINEyggklkdaiGI 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1173271762 226 R-------------KFNVGTELLVQWTKAAKTTFGETEINKSLRHNVIPANEAIKETVKHKI 274
Cdd:PRK07084  250 PeeqlrkaaksavcKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKI 311
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
4-271 5.87e-57

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 186.31  E-value: 5.87e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   4 TLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEE-EMVDAVLHLDH 82
Cdd:PRK09196    5 SLRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGEPFLRHLILAAVEEyPHIPVVMHQDH 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  83 ARDFDDIKEAIDSGYTSVMYDGSHLP-------FKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAED------ 149
Cdd:PRK09196   85 GNSPATCQRAIQLGFTSVMMDGSLKAdgktpasYEYNVDVTRKVVEMAHACGVSVEGELGCLGSLETGMGGEEDghgaeg 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 150 ----DKVYTKPEDALVFVKETGVDALAIAIGTNHGQFKSKTE-----VNIPLLKEIDARV-DVPLVIHGGTGVKEEdYPA 219
Cdd:PRK09196  165 klshDQLLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTRKptgdvLAIDRIKEIHARLpNTHLVMHGSSSVPQE-LLD 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1173271762 220 LIN----------------------NGIRKFNVGTELLVQWTKAAKTTFGETEINKSLRHNVIPANEAIKETVK 271
Cdd:PRK09196  244 IINeyggdmpetygvpveeiqegikHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKICK 317
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 6-277 1.06e-56

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 184.32  E-value: 1.06e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   6 KEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEEM---VDAVLHLDH 82
Cdd:PRK07315    7 EKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKVCKNLIENLVESMgitVPVAIHLDH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  83 ArDFDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIhVAEDDkvYTKPEDALVF 162
Cdd:PRK07315   87 G-HYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGI-IGKGE--LAPIEDAKAM 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 163 VkETGVDALAIAIGTNHGQFKSKTE-VNIPLLKEIDARV-DVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTK 240
Cdd:PRK07315  163 V-ETGIDFLAAGIGNIHGPYPENWEgLDLDHLEKLTEAVpGFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTECQIAFAN 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1173271762 241 AAKTTFGETEINKSL---------RHNVIPANEAIKETVKHKIGLF 277
Cdd:PRK07315  242 ATRKFARDYEANEAEydkkklfdpRKFLAPGVKAIQASVEERIDVF 287
PLN02858 PLN02858
fructose-bisphosphate aldolase
 6-277 4.47e-54

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 188.91  E-value: 4.47e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762    6 KEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNvLVHVMKAIAEEEMVDAVLHLDHARD 85
Cdd:PLN02858  1103 KELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIP-LVSCCIAAAEQASVPITVHFDHGTS 1181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   86 FDDIKEAIDSGYTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAEDDKVYTKPEDALVFVKE 165
Cdd:PLN02858  1182 KHELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTVEEYEAKLTDVDQAKEFIDE 1261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  166 TGVDALAIAIGTNHGQF-KSKTEVNIPLLKEIDA---RVDVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKA 241
Cdd:PLN02858  1262 TGIDALAVCIGNVHGKYpASGPNLRLDLLKELRAlssKKGVLLVLHGASGLPESLIKECIENGVRKFNVNTEVRTAYMEA 1341

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1173271762  242 AKTTFGETEInkslrHNVIPANEAIKETVKHKIGLF 277
Cdd:PLN02858  1342 LSSPKKTDLI-----DVMSAAKEAMKAVVAEKLRLF 1372
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
4-277 1.75e-52

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 174.97  E-value: 1.75e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   4 TLKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYIGMNVLVHVMKAIAEEE-MVDAVLHLDH 82
Cdd:PRK13399    5 TLRQLLDHAAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAEMYpDIPICLHQDH 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  83 ARDFDDIKEAIDSGYTSVMYDGSHLP-------FKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEGIHVAED------ 149
Cdd:PRK13399   85 GNSPATCQSAIRSGFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSLETGEAGEEDgvgaeg 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 150 ----DKVYTKPEDALVFVKETGVDALAIAIGTNHGQFKSKTE-----VNIPLLKEIDARV-DVPLVIHGGTGVKEEdYPA 219
Cdd:PRK13399  165 klshDQMLTDPDQAVDFVQRTGVDALAIAIGTSHGAYKFTRKpdgdiLAIDRIEEIHARLpNTHLVMHGSSSVPQE-LQE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 220 LIN----------------------NGIRKFNVGTELLVQWTKAAKTTFGETEINKSLRHNVIPANEAIKETVKHKIGLF 277
Cdd:PRK13399  244 IINayggkmketygvpveeiqrgikHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCKQRFEAF 323
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 6-250 6.22e-44

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 152.65  E-value: 6.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   6 KEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQ-TSVDTAKYIGMNV---------------LVHVMKAIA 69
Cdd:cd00453     2 QKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQfSNGGASFIAGKGVksdvpqgaailgaisGAHHVHQMA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  70 EEEMVDAVLHLDH--ARDFDDIKEAIDSG-----------YTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGT 136
Cdd:cd00453    82 EHYGVPVILHTDHcaKKLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 137 IGGTEEGIHVAEDDK--VYTKPEDALVFVKETG----VDALAIAIGTNHGQFKSKTEVNIP-LLKEIDARV--------- 200
Cdd:cd00453   162 TGGEEDGVDNSHMDAsaLYTQPEDVDYAYTELSkispRFTIAASFGNVHGVYKKGNVVLTPtILRDSQEYVskkhnlphn 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1173271762 201 DVPLVIHGGTGVKEEDYPALINNGIRKFNVGTELLVQWTKAAKTTFGETE 250
Cdd:cd00453   242 SLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANE 291
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 5-238 4.08e-21

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 91.40  E-value: 4.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762   5 LKEVTKTAEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYI---GMN-------VL--------VHVMk 66
Cdd:PRK09197    9 YQEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIagkGVKddgqgaaVLgaiagakhVHEV- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  67 aiAEEEMVDAVLHLDH-ARDFDD-IKEAIDSG-----------YTSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGE 133
Cdd:PRK09197   88 --AEHYGVPVILHTDHcAKKLLPwIDGLLDAGekhfaaggkplFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTLEIE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 134 LGTIGGTEEGI-HVAED-DKVYTKPEDALVFVKETGVDA----LAIAIGTNHGQFKSKtevNIPL----LKEIDARVD-- 201
Cdd:PRK09197  166 LGVTGGEEDGVdNSHEDnSKLYTQPEDVLYAYEALGKISgrftIAASFGNVHGVYKPG---NVKLrpeiLKDSQEYVSkk 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1173271762 202 -------VPLVIHGGTGVKEEDYPALINNGIRKFNVGTELlvQW 238
Cdd:PRK09197  243 fglpakpFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDT--QW 284
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 12-238 7.47e-21

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 90.51  E-value: 7.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  12 AEELNFTVGAFNTHNLEMLPAMLRAAKEMGAPIIIQTSVDTAKYI-GMNV--------------LVHVMKAIAEEEMVDA 76
Cdd:cd00946    11 AKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAFYaGKGLknekqkasiagaiaAAHHVRSMAEHYGVPV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762  77 VLHLDHARD-----FDDIKEAIDSGY--------TSVMYDGSHLPFKENILKTKAVVEYAHAHGVSVEGELGTIGGTEEG 143
Cdd:cd00946    91 VLHTDHCAKkllpwFDGLLEADEEYFkqhgeplfSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGITGGEEDG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173271762 144 I---HVAEDDkVYTKPEDALVFVKETGVDA----LAIAIGTNHGQFKSKTEVNIP-LLKEIDARV--------DVPL--V 205
Cdd:cd00946   171 VdnsGVDNAE-LYTQPEDVWYVYEALSKISpnfsIAAAFGNVHGVYKPGNVKLQPeILGEHQDYVreklgladDKPLyfV 249

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1173271762 206 IHGGTGVKEEDYPALINNGIRKFNVGTELlvQW 238
Cdd:cd00946   250 FHGGSGSTKEEIREAISYGVVKMNIDTDT--QW 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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