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Conserved domains on  [gi|1173275107|ref|WP_081134148|]
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sugar ABC transporter permease [Enterococcus durans]

Protein Classification

ABC transporter permease( domain architecture ID 10008345)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates including sugars, ions, amino acids, and peptides, among others

Gene Ontology:  GO:0055085|GO:0140359|GO:0042626|GO:0016020
PubMed:  31571164|27273632|26517919|18535149|17723295|25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 1-312 1.68e-142

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 404.47  E-value: 1.68e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107   1 MKKRKGLNHFFANLWRYKALVFMAIPGMLWMIFFFYIPVLANVVAFKNFHIsADGFLaslrESPWVGWDNFKFLFSSDQA 80
Cdd:COG4209    10 RKKKKRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIAFKDYNP-FKGIF----GSPWVGLKNFKFLFSSPDF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  81 FLITKNTVLYNVTFILLNLLISVVFAIIMSELRNKRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPDKGIFNQWITGHGG 160
Cdd:COG4209    85 WRVLRNTLLISLLKLVFGFPLPIILALLLNELRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 161 EAINWYNEPKYWPFILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVGN 240
Cdd:COG4209   165 EPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGN 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1173275107 241 IFRADFGLFYNIprNSGALYDVTQVLDTYIYNGLTSTGDFGMTAAAGLYQSVVGFILLMITNTIARRFDSES 312
Cdd:COG4209   245 ILNVGFEQIYLL--YNPLNYSTSDVIDTYVYRIGLQNGDYSYATAVGLFKSVVGLILVLIANKIAKKLGEES 314
 
Name Accession Description Interval E-value
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 1-312 1.68e-142

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 404.47  E-value: 1.68e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107   1 MKKRKGLNHFFANLWRYKALVFMAIPGMLWMIFFFYIPVLANVVAFKNFHIsADGFLaslrESPWVGWDNFKFLFSSDQA 80
Cdd:COG4209    10 RKKKKRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIAFKDYNP-FKGIF----GSPWVGLKNFKFLFSSPDF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  81 FLITKNTVLYNVTFILLNLLISVVFAIIMSELRNKRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPDKGIFNQWITGHGG 160
Cdd:COG4209    85 WRVLRNTLLISLLKLVFGFPLPIILALLLNELRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 161 EAINWYNEPKYWPFILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVGN 240
Cdd:COG4209   165 EPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGN 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1173275107 241 IFRADFGLFYNIprNSGALYDVTQVLDTYIYNGLTSTGDFGMTAAAGLYQSVVGFILLMITNTIARRFDSES 312
Cdd:COG4209   245 ILNVGFEQIYLL--YNPLNYSTSDVIDTYVYRIGLQNGDYSYATAVGLFKSVVGLILVLIANKIAKKLGEES 314
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
63-308 1.51e-12

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 66.77  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  63 SPWVGWDNFKFLFSSDQAFLITKNTVLYNVTFILLNLLISVVFAIIMSELrnKRLVKVYQTMSLLPYFLSWVIISYFVYA 142
Cdd:PRK10561   36 SQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYV--VRGSRFYQTLMLLPYAVAPAVAAVLWIF 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 143 FLSPDKGIFNqWITGHGGEAINWYNEPKYWPFILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVT 222
Cdd:PRK10561  114 LFNPGRGLIT-HFLAEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 223 LPQLVPLMTILTILavgNIFRADFGLFYNIPRNSGAlyDVTQVLDTYIYNgLTSTGDFGMTAAAGLYQSVVGFILLMITN 302
Cdd:PRK10561  193 LPLIAPVSFFLLVV---NLVYAFFDTFPVIDAATSG--GPVQATTTLIYK-IYREGFTGLDLSSSAAQSVVLMFLVIVLT 266


                  ....*.
gi 1173275107 303 TIARRF 308
Cdd:PRK10561  267 VVQFRY 272
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 86-242 6.47e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 48.81  E-value: 6.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  86 NTVLYNVTFILLNLLISVVFAIIMSELRNkRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPdkgifnqwitghggeAINW 165
Cdd:cd06261     3 NTLLLALIATLLALVLGLLLGIILARKRG-KLDRLLRRIIDLLLSLPSLVLGLLLVLLFGV---------------LLGW 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1173275107 166 YNEPKYWPFILVFIGTWkGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVGNIF 242
Cdd:cd06261    67 GILPGLGLPALILALLL-IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARAL 142
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 102-308 4.54e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 102 SVVFAIIMSELRNKRLVKVYQTMSLLPYFLSWVIISYFVYAflspdkgifnqwitghggeaINWYNEPKYWPFILVFIGT 181
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVV--------------------IAILSILGHGILPAIILAL 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 182 WKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVGNIFrADFGLFYNIPRNSGALYD 261
Cdd:pfam00528  61 LGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGAL-GGAVLLEFLGSWPGLGLL 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1173275107 262 VTQVLDTYIYNGLTstgdfGMTAAAGLYQSVVGFILLMITNTIARRF 308
Cdd:pfam00528 140 LIEAILGYDYPEIQ-----GPVLAAALILLLLNLLVDILQRLLDPRV 181
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 29-307 2.84e-03

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 39.28  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  29 LWMIFFFYIPVLANVVafKNFHISADGFlaslrespwVGWDNFKFLFSSDQAFLITKNTVLYNVTFILLNLLISVVFAII 108
Cdd:TIGR03262  12 LALLLFLLLPLLALLT--KSVYDSDGDF---------IGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 109 MSELRNKrLVKVYQTMSLLPYFLSWVI--ISyFVYAFLSpdKGIFNQWITGHGgeainwynepkywpfILVFIGTWKGIG 186
Cdd:TIGR03262  81 LTRSRIP-GKGAFRLVALLPLLAPSLLpaIS-LIYLFGN--QGLLKGLLGGFS---------------IYGFWGIVIGEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 187 YNS-----IIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQ----LVPLMTILTILAVgnifrADFGlfynIPRNSG 257
Cdd:TIGR03262 142 FYTfphalMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGakygLISAAFVVFTLVI-----TDFG----VPKVIG 212

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1173275107 258 ALYDvtqVLDTYIYNGLTSTGDFGMTAAAGLYQSVVGFILLMITNTIARR 307
Cdd:TIGR03262 213 GDYN---VLATDIYKQVIGQQNFPMGAVVGVLLLLPALLAFGIDRAIQRR 259
 
Name Accession Description Interval E-value
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 1-312 1.68e-142

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 404.47  E-value: 1.68e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107   1 MKKRKGLNHFFANLWRYKALVFMAIPGMLWMIFFFYIPVLANVVAFKNFHIsADGFLaslrESPWVGWDNFKFLFSSDQA 80
Cdd:COG4209    10 RKKKKRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIAFKDYNP-FKGIF----GSPWVGLKNFKFLFSSPDF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  81 FLITKNTVLYNVTFILLNLLISVVFAIIMSELRNKRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPDKGIFNQWITGHGG 160
Cdd:COG4209    85 WRVLRNTLLISLLKLVFGFPLPIILALLLNELRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 161 EAINWYNEPKYWPFILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVGN 240
Cdd:COG4209   165 EPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGN 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1173275107 241 IFRADFGLFYNIprNSGALYDVTQVLDTYIYNGLTSTGDFGMTAAAGLYQSVVGFILLMITNTIARRFDSES 312
Cdd:COG4209   245 ILNVGFEQIYLL--YNPLNYSTSDVIDTYVYRIGLQNGDYSYATAVGLFKSVVGLILVLIANKIAKKLGEES 314
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
1-308 5.85e-50

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 167.62  E-value: 5.85e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107   1 MKKRKGLNHFFANLWRYKALVFMAIPGMLWMIFFFYIPVLANVV-AFKNFHISADgflaslrESPWVGWDNFKFLFSSDQ 79
Cdd:COG1175     1 MTTTTSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYlSFTDWNLLGP-------PPEFVGLDNYARLFTDPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  80 AFLITKNTVLYNVTFILLNLLISVVFAIIMSelRNKRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPDKGIFNQWITGHG 159
Cdd:COG1175    74 FWNALGNTLLFTVVSVPLQLVLGLLLALLLN--RKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 160 GEAINWYNEPKYWPFILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVG 239
Cdd:COG1175   152 LEPINWLGDPSLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTI 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1173275107 240 NIFRAdFGLFYNIprNSGALYDVTQVLDTYIYNGLTSTGDFGMTAAAglyqSVVGFILLMITNTIARRF 308
Cdd:COG1175   232 GALQV-FDLVYVL--TGGGPGNSTTTLVLYIYQTAFQQFDFGYASAI----AVVLFLIILVLTLLQLRL 293
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 12-307 2.37e-14

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 72.10  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  12 ANLWRYKALVFMAIPGMLWMIFFFYIPVLANVVafknfhISADGFLASLRESPWVGWDNFKFLFSSDQAFLITKNTVLYN 91
Cdd:COG1176     3 AALRRRLRPLLLLLPALLWLLLFFVLPLLLLLV------YSFTTRDPYGGVVPGFTLENYARLFTDPLYLKVLLRTLWIA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  92 VTFILLNLLISVVFAIIMSeLRNKRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPDkGIFNQWITghggeAINWYNEPK- 170
Cdd:COG1176    77 LLTTLICLLLGYPIAYFLA-RAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRN-GLLNSLLL-----ALGLIDEPLr 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 171 --YWPFILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILavgnIFRADFGL 248
Cdd:COG1176   150 llYTEFAVVIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLL----VFIPALGA 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1173275107 249 FYnIPRNSGALYdvTQVLDTYIYNGLTSTGDFGMTAAAGLYQSVVGFILLMITNTIARR 307
Cdd:COG1176   226 FV-TPALLGGGK--VLMIGNLIYQQFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRR 281
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
63-308 1.51e-12

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 66.77  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  63 SPWVGWDNFKFLFSSDQAFLITKNTVLYNVTFILLNLLISVVFAIIMSELrnKRLVKVYQTMSLLPYFLSWVIISYFVYA 142
Cdd:PRK10561   36 SQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYV--VRGSRFYQTLMLLPYAVAPAVAAVLWIF 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 143 FLSPDKGIFNqWITGHGGEAINWYNEPKYWPFILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVT 222
Cdd:PRK10561  114 LFNPGRGLIT-HFLAEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 223 LPQLVPLMTILTILavgNIFRADFGLFYNIPRNSGAlyDVTQVLDTYIYNgLTSTGDFGMTAAAGLYQSVVGFILLMITN 302
Cdd:PRK10561  193 LPLIAPVSFFLLVV---NLVYAFFDTFPVIDAATSG--GPVQATTTLIYK-IYREGFTGLDLSSSAAQSVVLMFLVIVLT 266


                  ....*.
gi 1173275107 303 TIARRF 308
Cdd:PRK10561  267 VVQFRY 272
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
56-307 4.91e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 66.34  E-value: 4.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  56 FLASLRESPWVGWDNFKFLFSSDQAFLITKNTVLYNVTFILLNLLISVVFAIIMSeLRNKRLVKVYQTMSLLPYFLSWVI 135
Cdd:COG1178    28 LLALLLRAFTDGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWLLA-RTDFPGRRLLRWLLLLPLALPPYV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 136 ISYFVYAFLSPDkGIFNQWITGHGG-EAINWYNepkYWPFILVFigtwkGIGYNSIIYF---ASVMGIDPTYYEAAMVDG 211
Cdd:COG1178   107 VALAWIALFGPN-GLLNTLLRALFGlEPPDIYG---LGGIILVL-----VLFNYPYVYLllrAALRSIDASLEEAARSLG 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 212 ASKWQQIKHVTLPQLVP-LMTILTILAVGNIfrADFGLFYNIprnsGALYdvtQVLDTYIYNGLTSTGDFGMTAAAGLYQ 290
Cdd:COG1178   178 ASPWRAFRRVTLPLLRPaIAAGALLVFLLCL--ADFGTPLVL----GGGY---TTLTTAIYQAWLGDFDLGAAAALALVL 248

                         250
                  ....*....|....*..
gi 1173275107 291 SVVGFILLMITNTIARR 307
Cdd:COG1178   249 LLLVLLLLLLERRLRRR 265
malF PRK10999
maltose ABC transporter permease MalF;
51-235 4.87e-11

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 63.06  E-value: 4.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  51 ISADGFLASLRESP----WVGWDNFKFLFSSD---QAFL-ITKNTVLYNVTFILLNLLISVVFAIIMS--ELRNKrlvKV 120
Cdd:PRK10999  246 INADGNWGGEKLSPgftvTIGWKNFTRVFTDEgiqKPFIaIFIWTVVFSLLTVVLTVAVGMVLACLVQweALKGK---AV 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 121 YQTMSLLPY----FLSWVIIsyfvyaflspdKGIFNQWItghgGEaIN------------WYNEPKYWPFILVFIGTWKG 184
Cdd:PRK10999  323 YRVLLILPYavpsFISILIF-----------KGLFNQSF----GE-INmmlsalfgikpaWFSDPTLAKTMILIVNTWLG 386

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1173275107 185 IGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTI 235
Cdd:PRK10999  387 YPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFKITLPLLIKPLTPLMI 437
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
15-307 2.36e-08

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 55.17  E-value: 2.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  15 WRYKALVFMAipgmLWMIFFFYIPVLAnvvafknfhISADGFLASLRESPwvGWDNFKFLFSSDQAFLITKNTVLYNVTF 94
Cdd:COG1178   286 WRWLALALCL----LLVLLGLLLPLLA---------LLLWSLTKALDDNL--TLDNYRFVLLDPSLLRALLNSLLLALLA 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  95 ILLNLLISVVFAIIMSELRNkRLVKVYQTMSLLPYFLSWVIISY-FVYAFLSPdkgiFNQWITGhggeainwynepkyWP 173
Cdd:COG1178   351 ALLAVLLALLLAYLVRRRRG-RLARLLDRLAMLPYAVPGIVLGLgLLLLFNRP----LPLLLYG--------------TL 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 174 FILVFIGTWKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVP-LMTILTILAVgNIFRaDFG---LF 249
Cdd:COG1178   412 AILVLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPgLLAAALLVFV-TSMK-ELSatlLL 489

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1173275107 250 YNiprnsgalyDVTQVLDTYIYNgLTSTGDFGMTAAAGLYQSVVGFILLMITNTIARR 307
Cdd:COG1178   490 RP---------PGFETLAVLIYQ-LASSGRYGEAAALALLLVLVSLLPVLLLERLLGR 537
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 199-308 1.06e-07

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 52.06  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 199 IDPTYYEAAMVDGASKWQQIKHVTLPQLVP-LMT--ILT-ILAVGnifraDFG--LFYniprnSGALYDVTQVLDTYIYN 272
Cdd:COG0555   162 LDPELEEAAATLGASRWQTFRRVILPLLLPaLLTgfALAfARALG-----EFGavIFI-----AGNLPMKTEILPLLIYL 231

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1173275107 273 GLtSTGDFGMTAAAGLYQSVVGFILLMITNTIARRF 308
Cdd:COG0555   232 KL-EEGDYAGATAIALVLLLISFLLLLLINLLQRRS 266
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 86-242 6.47e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 48.81  E-value: 6.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  86 NTVLYNVTFILLNLLISVVFAIIMSELRNkRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPdkgifnqwitghggeAINW 165
Cdd:cd06261     3 NTLLLALIATLLALVLGLLLGIILARKRG-KLDRLLRRIIDLLLSLPSLVLGLLLVLLFGV---------------LLGW 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1173275107 166 YNEPKYWPFILVFIGTWkGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVGNIF 242
Cdd:cd06261    67 GILPGLGLPALILALLL-IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARAL 142
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 31-228 1.26e-06

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 48.95  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  31 MIFFFYIPVLANVVafknFHISADGFLASlresPWVGW--DNFKFLFSSDQAFLITKNTVLYNVTFILLNLLISVVFAII 108
Cdd:COG1177    16 VLLFLYLPILVLVL----YSFNDSWFLTF----PPEGFtlRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 109 MSELRnKRLVKVYQTMSLLPYFLSWVIISYFVYAFLSPDkGIFNQWITghggeainwynepkywpfiLVFIGTWKGIGYN 188
Cdd:COG1177    88 LARYR-FRGRRLLLALLLLPLVVPGIVLGVALLLLFSAL-GLSGGLWG-------------------LILAHVVFTLPFV 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1173275107 189 SIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVP 228
Cdd:COG1177   147 VLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAP 186
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 2-237 7.12e-06

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 46.68  E-value: 7.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107   2 KKRKGLNHFFANLWRYKALVFMAIpgmLWMIFFFYIpVLAnvvAFknfhiSADGFLASLRESPW-VGWDNFKFLFSSDQA 80
Cdd:COG3833     4 RKSRKRRRRLKLGLRHLVLIILAI---IALFPILWV-VSA---SF-----NPGGSLYSSSLIPEnFTLENYKKLFTETPF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  81 FLITKNTVLYNVTFILLNLLISVVFAIIMSELR---NKRLVKVYQTMSLLPYFLSWVIIsYFVYAFLspdkGIFNQwitg 157
Cdd:COG3833    72 LRWFLNSLIVAVVTAIISVFLAALAAYAFSRFRfkgRKAGLLALLLLQMFPAFLALVAL-YLLLSAL----GLLNT---- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 158 hggeainwynepkYWPFILVFIGTwkGIGYNSII---YFASvmgIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILT 234
Cdd:COG3833   143 -------------LLGLILVYLGG--AIPFNTWLmkgYFDT---IPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVA 204


                  ...
gi 1173275107 235 ILA 237
Cdd:COG3833   205 LLS 207
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 68-237 2.09e-05

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 45.09  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  68 WDNFKFLFSSDQAFLITKNTVLYNVTFILLNLLISVV--FAIIMSELRNKRLVkvyqtmsllpyfLSWVIISYFV--YAF 143
Cdd:COG0395    60 LENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLaaYALARFRFRGRKLL------------FLLILATLMIpgQVL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 144 LSPDKGIFNQwitghggeaINWYNepKYWPFILVFIGTwkGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTL 223
Cdd:COG0395   128 LIPLYLLFRQ---------LGLLN--TYWGLILPYLAF--GLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVL 194

                         170
                  ....*....|....
gi 1173275107 224 PQLVPLMTILTILA 237
Cdd:COG0395   195 PLSKPALATVAIFT 208
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 102-308 4.54e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 102 SVVFAIIMSELRNKRLVKVYQTMSLLPYFLSWVIISYFVYAflspdkgifnqwitghggeaINWYNEPKYWPFILVFIGT 181
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVV--------------------IAILSILGHGILPAIILAL 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 182 WKGIGYNSIIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILAVGNIFrADFGLFYNIPRNSGALYD 261
Cdd:pfam00528  61 LGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGAL-GGAVLLEFLGSWPGLGLL 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1173275107 262 VTQVLDTYIYNGLTstgdfGMTAAAGLYQSVVGFILLMITNTIARRF 308
Cdd:pfam00528 140 LIEAILGYDYPEIQ-----GPVLAAALILLLLNLLVDILQRLLDPRV 181
malG PRK10998
maltose ABC transporter permease MalG;
192-237 1.41e-03

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 39.69  E-value: 1.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1173275107 192 YFASvmgIDPTYYEAAMVDGASKWQQIKHVTLPQLVPLMTILTILA 237
Cdd:PRK10998  180 YFET---IDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILS 222
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 29-307 2.84e-03

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 39.28  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107  29 LWMIFFFYIPVLANVVafKNFHISADGFlaslrespwVGWDNFKFLFSSDQAFLITKNTVLYNVTFILLNLLISVVFAII 108
Cdd:TIGR03262  12 LALLLFLLLPLLALLT--KSVYDSDGDF---------IGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 109 MSELRNKrLVKVYQTMSLLPYFLSWVI--ISyFVYAFLSpdKGIFNQWITGHGgeainwynepkywpfILVFIGTWKGIG 186
Cdd:TIGR03262  81 LTRSRIP-GKGAFRLVALLPLLAPSLLpaIS-LIYLFGN--QGLLKGLLGGFS---------------IYGFWGIVIGEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173275107 187 YNS-----IIYFASVMGIDPTYYEAAMVDGASKWQQIKHVTLPQ----LVPLMTILTILAVgnifrADFGlfynIPRNSG 257
Cdd:TIGR03262 142 FYTfphalMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGakygLISAAFVVFTLVI-----TDFG----VPKVIG 212

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1173275107 258 ALYDvtqVLDTYIYNGLTSTGDFGMTAAAGLYQSVVGFILLMITNTIARR 307
Cdd:TIGR03262 213 GDYN---VLATDIYKQVIGQQNFPMGAVVGVLLLLPALLAFGIDRAIQRR 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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