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Conserved domains on  [gi|1174947120|ref|WP_081620339|]
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AlpA family transcriptional regulator [Ancylobacter sp. FA202]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10007181)

helix-turn-helix DNA-binding protein similar to Mycobacterium phage excisionase, which is necessary for the excision of prophage from the host genome by site-specific recombination at the attachment site

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  15808743|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
6-68 1.79e-15

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


:

Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 64.18  E-value: 1.79e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174947120  6 STLSKRTIRRSQLREIVPLADTTIYDMEQRGEFPQRFYLTSRCVVWDLAEVEAWLAMRRQASN 68
Cdd:COG3311    2 SLPPDRLLRLKEVAELLGVSRSTIYRLIKKGEFPKPVKLGGRSVRWRESEVEAWLAARIAASR 64
 
Name Accession Description Interval E-value
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
6-68 1.79e-15

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 64.18  E-value: 1.79e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174947120  6 STLSKRTIRRSQLREIVPLADTTIYDMEQRGEFPQRFYLTSRCVVWDLAEVEAWLAMRRQASN 68
Cdd:COG3311    2 SLPPDRLLRLKEVAELLGVSRSTIYRLIKKGEFPKPVKLGGRSVRWRESEVEAWLAARIAASR 64
Phage_AlpA pfam05930
Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and ...
 11-60 2.10e-10

Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light. Several of the sequences in this family are thought to be DNA-binding proteins.


Pssm-ID: 399137  Cd Length: 51  Bit Score: 51.18  E-value: 2.10e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1174947120 11 RTIRRSQLREIVPLADTTIYDMEQRGEFPQRFYLTSRCVVWDLAEVEAWL 60
Cdd:pfam05930  2 RILRLREVEQKTGLSRSSIYRLMKEGEFPKPVRLGVRAVAWVESEIDQWI 51
 
Name Accession Description Interval E-value
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
6-68 1.79e-15

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 64.18  E-value: 1.79e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174947120  6 STLSKRTIRRSQLREIVPLADTTIYDMEQRGEFPQRFYLTSRCVVWDLAEVEAWLAMRRQASN 68
Cdd:COG3311    2 SLPPDRLLRLKEVAELLGVSRSTIYRLIKKGEFPKPVKLGGRSVRWRESEVEAWLAARIAASR 64
Phage_AlpA pfam05930
Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and ...
 11-60 2.10e-10

Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light. Several of the sequences in this family are thought to be DNA-binding proteins.


Pssm-ID: 399137  Cd Length: 51  Bit Score: 51.18  E-value: 2.10e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1174947120 11 RTIRRSQLREIVPLADTTIYDMEQRGEFPQRFYLTSRCVVWDLAEVEAWL 60
Cdd:pfam05930  2 RILRLREVEQKTGLSRSSIYRLMKEGEFPKPVRLGVRAVAWVESEIDQWI 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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