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Conserved domains on  [gi|1175376632|ref|WP_081924424|]
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MULTISPECIES: MFS transporter [Brevibacillus]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 7-205 1.19e-34

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 126.19  E-value: 1.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   7 YSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLL 86
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  87 IPLLS-----SVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLC 161
Cdd:cd06173    81 LALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1175376632 162 IFINGITFFFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:cd06173   161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYL 204
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 7-205 1.19e-34

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 126.19  E-value: 1.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   7 YSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLL 86
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  87 IPLLS-----SVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLC 161
Cdd:cd06173    81 LALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1175376632 162 IFINGITFFFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:cd06173   161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYL 204
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
4-205 2.29e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 84.26  E-value: 2.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   4 WRTYSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGAL 83
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  84 VLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIF 163
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1175376632 164 INGITFFFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:COG2814   169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLL 210
MFS_1 pfam07690
Major Facilitator Superfamily;
10-205 2.16e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.52  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  10 LLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGP-VARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIP 88
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFsLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  89 LLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGIT 168
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1175376632 169 FFFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL 197
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 23-152 7.93e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 51.85  E-value: 7.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   23 IYLVALNIFILDMTGSASAVAGIYIVGPVarLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPL---LSSVWVVYAI 99
Cdd:PRK08633    32 IQNTLIKAYDGSEQVILTAIVNALFLLPF--LLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLayyLGWFWLAFAV 109

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1175376632  100 LFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVL 152
Cdd:PRK08633   110 TFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFL 162
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 31-179 8.34e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 39.28  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  31 FILDMTGSASAVAGIYIvgpvARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFF 110
Cdd:TIGR00881  25 IGLSKTDLGLLLSSFSI----AYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMG 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175376632 111 GPSSTYYVTKLVTPEERrrfNSIMSMLNAGAFLIGPAIAGVListtGTSLCIFINGITFFFCAALIALL 179
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSER---GTWVSFWNCSHNVGGGLLPPLV----LFGIAELYSWHWVFIVPGIIAII 162
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 7-205 1.19e-34

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 126.19  E-value: 1.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   7 YSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLL 86
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  87 IPLLS-----SVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLC 161
Cdd:cd06173    81 LALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1175376632 162 IFINGITFFFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:cd06173   161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYL 204
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
4-205 2.29e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 84.26  E-value: 2.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   4 WRTYSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGAL 83
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  84 VLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIF 163
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1175376632 164 INGITFFFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:COG2814   169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLL 210
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 10-204 4.87e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 75.31  E-value: 4.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  10 LLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPL 89
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  90 LSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGITF 169
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1175376632 170 FFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRI 204
Cdd:cd17325   161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL 195
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-179 9.49e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.45  E-value: 9.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   1 MGNWRTYSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAG-IYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVA 79
Cdd:cd17325   195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGlLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  80 RGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTS 159
Cdd:cd17325   275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354

                         170       180
                  ....*....|....*....|
gi 1175376632 160 LCIFINGITFFFCAALIALL 179
Cdd:cd17325   355 TPFLAAAALLLLAAVLFLLL 374
MFS_1 pfam07690
Major Facilitator Superfamily;
10-205 2.16e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.52  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  10 LLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGP-VARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIP 88
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFsLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  89 LLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGIT 168
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1175376632 169 FFFCAALIALLPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL 197
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 9-180 2.64e-14

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 70.33  E-value: 2.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAG-IYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLI 87
Cdd:cd17329     3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGlVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  88 PLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGI 167
Cdd:cd17329    83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVL 162

                         170
                  ....*....|...
gi 1175376632 168 TFFFCAALIALLP 180
Cdd:cd17329   163 FLLAALVLLFLLP 175
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 9-179 2.25e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 64.56  E-value: 2.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGI-YIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLI 87
Cdd:cd06173   212 LLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLlLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  88 PLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGI 167
Cdd:cd06173   292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGA 371

                         170
                  ....*....|..
gi 1175376632 168 TFFFCAALIALL 179
Cdd:cd06173   372 LLLLAALLLLLL 383
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 16-200 9.03e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.00  E-value: 9.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  16 VSYLGNWIYLVALNIFILDMTGS---ASAVAGIYIVgpvARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSS 92
Cdd:cd17489     7 FFFLSFYLLLPVLPLYAHDLGGSeavAGLVVGLFTL---AALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  93 VWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGITFFFC 172
Cdd:cd17489    84 VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLA 163

                         170       180       190
                  ....*....|....*....|....*....|
gi 1175376632 173 AALIALLPDV--SDEALQRRQPLSWNMIVN 200
Cdd:cd17489   164 LLLVFLVKDPppVAAEEAEAGTRAFRRLVE 193
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
4-179 3.16e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.42  E-value: 3.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   4 WRTYSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGAL 83
Cdd:COG2271     9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  84 VLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIF 163
Cdd:COG2271    89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168

                         170
                  ....*....|....*.
gi 1175376632 164 INGITFFFCAALIALL 179
Cdd:COG2271   169 ILGLPGLLLALLRFWL 184
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 10-205 6.42e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.52  E-value: 6.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  10 LLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPL 89
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  90 LSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSL--CIFINGI 167
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWraVFLIAAA 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1175376632 168 TFFFCAALIAL-LPDVSDEALQRRQPLSWNMIVNDWRIV 205
Cdd:cd06174   161 LALLAAILLLLvVPDPPESARAKNEEASSKSVLKLLKRV 199
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-181 1.19e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.44  E-value: 1.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   1 MGNWRTYSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVAR 80
Cdd:COG0477    10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  81 GALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSL 160
Cdd:COG0477    90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169

                         170       180
                  ....*....|....*....|.
gi 1175376632 161 CIFINGITFFFCAALIALLPD 181
Cdd:COG0477   170 IFLINAPLGLLALVLRLRLPE 190
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-180 1.97e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYLVALNIFILDMTG-SASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRK--LMIYSDVARGALVL 85
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  86 LIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFIN 165
Cdd:COG2271   264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343

                         170
                  ....*....|....*
gi 1175376632 166 GITFFFCAALIALLP 180
Cdd:COG2271   344 AALALLAALLALLLL 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
4-141 3.73e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 52.28  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   4 WRTYSLLLCGIGVSYLGNWIYLVALNIFILDMTG-SASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGA 82
Cdd:COG2814   206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1175376632  83 LVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGA 141
Cdd:COG2814   286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 23-152 7.93e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 51.85  E-value: 7.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   23 IYLVALNIFILDMTGSASAVAGIYIVGPVarLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPL---LSSVWVVYAI 99
Cdd:PRK08633    32 IQNTLIKAYDGSEQVILTAIVNALFLLPF--LLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLayyLGWFWLAFAV 109

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1175376632  100 LFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVL 152
Cdd:PRK08633   110 TFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFL 162
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 16-177 1.25e-06

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 48.21  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  16 VSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLS---- 91
Cdd:pfam05977  21 ASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAglgl 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  92 -SVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGITFF 170
Cdd:pfam05977 101 lSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYF 180


                  ....*..
gi 1175376632 171 FCAALIA 177
Cdd:pfam05977 181 AVIAALW 187
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 24-183 2.00e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.19  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  24 YLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIA 103
Cdd:cd17330    18 VLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632 104 NVAGSFFGPSSTYyVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSL-CIFINGITFFFCAALIALLPDV 182
Cdd:cd17330    98 GLTGGNVSVAQAY-IADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALpFLVAAALALLNLVLVLFFLPPL 176


                  .
gi 1175376632 183 S 183
Cdd:cd17330   177 R 177
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 9-179 3.03e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 3.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYlVALNIFILDMTG-SASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLI 87
Cdd:cd17329   205 FLLASFLISLIYFQLE-STLPVYVVEILGlGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  88 PLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGI 167
Cdd:cd17329   284 AFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAA 363

                         170
                  ....*....|..
gi 1175376632 168 TFFFCAALIALL 179
Cdd:cd17329   364 LGLIAAALLLGL 375
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
38-186 6.85e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 6.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  38 SASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYY 117
Cdd:COG0738    41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPY 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175376632 118 VTkLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLIS---TTGTSLCIFINGITFFFCAALIAL--LPDVSDEA 186
Cdd:COG0738   121 VA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRskLPEIEEEE 193
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-179 8.19e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 8.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   1 MGNWRTY--SLLLCGIGVSYLG--NWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLtqfwAGSLIDRVNRRKLMIYS 76
Cdd:COG2223   202 LRDPRFWllSLLYFGTFGSFIGfsSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPL----GGWLSDRIGGRRVLLIV 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  77 DVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTY-YVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLIST 155
Cdd:COG2223   278 FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFaLVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

                         170       180
                  ....*....|....*....|....
gi 1175376632 156 TGTSLCIFINGITFFFCAALIALL 179
Cdd:COG2223   358 TGSYTAAFLVFAVLALVALVLTLL 381
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
61-179 9.82e-06

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 45.05  E-value: 9.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  61 GSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAG 140
Cdd:PRK11646   67 GAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSA 146

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1175376632 141 AFLIGPAIAGVLISTTGTSLCiFINGITFFFCAALIALL 179
Cdd:PRK11646  147 GAVIGALLGSWLLQYDFRLVC-ATGAVLFVLAAAFNAWL 184
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-178 1.03e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.23  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  37 GSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTY 116
Cdd:cd17324   231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT 310

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1175376632 117 YVTKLVtPEERRRFNSI-MSMLNAGAfLIGPAIAGVLISTTGTSLCIFInGITFFFCAALIAL 178
Cdd:cd17324   311 RVLRLA-PEARGLASSLyLAAYNLGG-ALGAALGGLVLDHGGWAGVGWV-GAALLLLALLLAL 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 31-179 1.39e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  31 FILDMTGSASAVA-GIYIVGP-VARLLTQFWAGSLID-RVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAG 107
Cdd:cd17474   223 FLLELLYGISPIIiGLLFAGWsVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGL 302

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175376632 108 SFFGPSSTYYVTKLVTPEERrrfNSIMSMLNAGAFL---IGPAIAGVLISTTGTSLcIFINGITFFFCAALIALL 179
Cdd:cd17474   303 GLNLPLLTTLVTELAPEEER---GTASSLYNFVRFLgqaVGPLLFGLLLEIFGLSA-PFLVGAAIALAAAVLLAL 373
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 10-179 1.66e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.47  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  10 LLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPL 89
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  90 LSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPaiagVLISTTGTSLCIFINGITF 169
Cdd:cd17477    81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGP----LLLALVGTAGALPFLIAAV 156

                         170
                  ....*....|
gi 1175376632 170 FFCAALIALL 179
Cdd:cd17477   157 LLLLALVPLL 166
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 9-175 2.34e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.09  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIP 88
Cdd:cd17477   192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLP 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  89 LLSSV-WVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTS-LCIFING 166
Cdd:cd17477   272 LVPGLpLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHgLFLFLAA 351


                  ....*....
gi 1175376632 167 ITFFFCAAL 175
Cdd:cd17477   352 VALLFLLFL 360
PRK10489 PRK10489
enterobactin transporter EntS;
16-193 7.68e-05

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 42.66  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  16 VSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIysdVARGALVLLIPLLS---- 91
Cdd:PRK10489   28 ISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLIL---LARGTCGLGFIGLAlnaf 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  92 ----SVWVVYAILFIANVAGSfFGPSSTYYVTKLVTPEERRRFNSIMSMLNA--GAfLIGPAIAGVLISTTGTSLCIFIN 165
Cdd:PRK10489  105 lpepSLLAIYLLGLWDGFFGS-LGVTALLAATPALVGRENLMQAGAITMLTVrlGS-VISPALGGLLIAAGGVAWNYGLA 182

                         170       180
                  ....*....|....*....|....*...
gi 1175376632 166 GITFFFCAALIALLPDVSDEALQRRQPL 193
Cdd:PRK10489  183 AAGTFITLLPLLRLPALPPPPQPREHPL 210
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 47-179 1.25e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 41.88  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  47 IVGPVARLLTQFWAGSLIDRVNRRKLMIYSDV--ARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKL--- 121
Cdd:cd17386    37 LMGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVglLLSSLILVLIVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASFayi 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175376632 122 --VTPEERRRFN-SIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFING-------ITFFFCAALIALL 179
Cdd:cd17386   117 sdISSEKKRTYRmAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAalllialLYILFFLTLLILL 184
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 45-178 1.32e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  45 IYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTP 124
Cdd:cd17489   232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1175376632 125 EERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSlcifingITFFFCAALIAL 178
Cdd:cd17489   312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYR-------AMFLLAAVVVLL 358
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
5-157 1.57e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   5 RTYSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIY-IVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGAL 83
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLlALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  84 VLLIPLL--SSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRR-------FNSIMSMLNAGAFLIGPAIAGVLIS 154
Cdd:COG2211   308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLLA 387


                  ...
gi 1175376632 155 TTG 157
Cdd:COG2211   388 LFG 390
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
9-179 1.67e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.40  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYLVALNIFILDMTG----SASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALV 84
Cdd:COG2223     5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEefglSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  85 LLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFI 164
Cdd:COG2223    85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164

                         170
                  ....*....|....*
gi 1175376632 165 NGITFFFCAALIALL 179
Cdd:COG2223   165 LGILLLVVAVLAWLF 179
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 60-194 2.11e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  60 AGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNA 139
Cdd:cd17324    54 LGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLT 133

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1175376632 140 GAFLIGPAIAGVLISTTGTSLC-IFINGITFFFCAALIALLPDVSDEALQRRQPLS 194
Cdd:cd17324   134 LGLVLGRPLGGLLGQLLGWRAAfLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLS 189
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 31-171 2.81e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 40.67  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  31 FILDMTGSASAVAGIYIVGPVARlltqfwagslidRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFF 110
Cdd:cd17331   247 YLMSYAGVLGMVVQGLLVGPLTK------------RFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVL 314

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175376632 111 GPSSTYYVTKLVTPEERrrfNSIMSM---LNAGAFLIGPAIAGVLISTTG----TSLCIFINGITFFF 171
Cdd:cd17331   315 YTVITSLLTKAVPPEDT---GTALGLshaLFSLVRTVSPTIGGALLQAYGfpsfGLLGAAINGLLTVY 379
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 31-179 4.41e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 40.25  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  31 FILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIdRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFF 110
Cdd:cd17319   210 RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL-RGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAA 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175376632 111 GPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTslciFINGITFFFCAALIALL 179
Cdd:cd17319   289 SPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGS----YTAAFLFLAAVALLAAL 353
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 32-178 5.22e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.93  E-value: 5.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  32 ILDMTGSASAVAGIYIVGPVARLLTQF----WAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAG 107
Cdd:cd17388    26 LREFVGDSADAATHYGVLLALYALMQFifapILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITG 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1175376632 108 SFFGPSSTYyVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVL--ISTTgtslcifingITFFFCAALIAL 178
Cdd:cd17388   106 ATGAVAAAY-IADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLgeISPR----------APFLVAAGLNGL 167
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 16-167 6.44e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.87  E-value: 6.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  16 VSYLGNWIYLVALNIFILDMTGSASAVAGI-YIVGPVARLLTQFW-AGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSV 93
Cdd:cd17330   185 LIALAFAGLESVFSLFLKDRFGFSPSQIGLlLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSV 264

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175376632  94 WVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGI 167
Cdd:cd17330   265 PLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 31-179 8.34e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 39.28  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  31 FILDMTGSASAVAGIYIvgpvARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFF 110
Cdd:TIGR00881  25 IGLSKTDLGLLLSSFSI----AYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMG 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175376632 111 GPSSTYYVTKLVTPEERrrfNSIMSMLNAGAFLIGPAIAGVListtGTSLCIFINGITFFFCAALIALL 179
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSER---GTWVSFWNCSHNVGGGLLPPLV----LFGIAELYSWHWVFIVPGIIAII 162
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 3-180 9.48e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.10  E-value: 9.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   3 NWRTYSLLLCgIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGA 82
Cdd:cd17335   197 NPRVLAFLLV-AFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVV 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  83 LVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGA-FLIGPAIAGVLISTTGTSLC 161
Cdd:cd17335   276 RWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLgGGLGSLIGGYLYEAFGARTT 355

                         170
                  ....*....|....*....
gi 1175376632 162 IFINGITFFFCAALIALLP 180
Cdd:cd17335   356 FRFFAIAALAGLLAFFLIQ 374
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 9-178 1.77e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.35  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYI-VGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLI 87
Cdd:cd17316   181 LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLlLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  88 PLL--SSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFIN 165
Cdd:cd17316   261 FYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340

                         170
                  ....*....|...
gi 1175376632 166 GITFFFCAALIAL 178
Cdd:cd17316   341 LALLAIVALIVAL 353
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 5-155 2.04e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   5 RTYSLLLCGIGVSYLGNWIYLVALNIFILDMTGSASAVAGIY-IVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGA- 82
Cdd:cd17321   168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAlLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVg 247

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175376632  83 --LVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLIST 155
Cdd:cd17321   248 llLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTA 322
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 24-179 2.31e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  24 YLVALNI-FILDMTGSASA-VAGIYI-VGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAIL 100
Cdd:cd17473   214 YVIPIQLpFLLQERGGGSAaLIGLALaIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGA 293

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175376632 101 FIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGITFFFCAALIALL 179
Cdd:cd17473   294 ILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 66-180 2.33e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 37.92  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  66 RVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIG 145
Cdd:cd17352   246 RIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVG 325

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1175376632 146 PAIAGVLISTTGT-SLCIFINGITFFFCAALIALLP 180
Cdd:cd17352   326 PPIAGLLRDYTGDyDAAFYFCGACLLLSGVLLFLLP 361
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 9-157 2.60e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.02  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632   9 LLLCGIGVSYLGNWIYLVALNIFILDMTG----SASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALV 84
Cdd:cd17355     3 VVLAVTFLILILSWGIRYYFGVFIIPIIAefgwSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175376632  85 LLIPLLSSVWVVYAILFIANVAGS-FFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTG 157
Cdd:cd17355    83 VLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG 156
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 38-179 3.78e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 37.51  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  38 SASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLL----SSVWVVYAILFIANVA-GSFFGP 112
Cdd:cd17369   262 DRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLldtgSTWLIVLAAVVVLGVLhGMMYGP 341

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175376632 113 SSTYYVtKLVTPEERRRFNSIMSMLNAGAF-LIGPAIAGVLISTTGTSLCIFIngitFFFCAALIALL 179
Cdd:cd17369   342 QAAFLA-ELFPTRVRYTGASLGYQLGAILGgGFAPLIATALVAATGSWWPVAL----YLAALAVISLV 404
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 54-157 3.98e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 37.16  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  54 LLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSI 133
Cdd:cd17319    52 ALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGL 131

                          90       100
                  ....*....|....*....|....
gi 1175376632 134 MSMLNAGAFLIGPAIAGVLISTTG 157
Cdd:cd17319   132 FNSGAPLGAAIGPPLSGWLLLLFG 155
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 22-178 4.07e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 37.14  E-value: 4.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  22 WIYLVALNIF-------------ILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIP 88
Cdd:cd17370   203 WLYLLAVALFalgnfsfaflilrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFA 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  89 LLSSVWVVYAILFIANVAGSFFGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLcIFINGIT 168
Cdd:cd17370   283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA-AFLFSAV 361

                         170
                  ....*....|
gi 1175376632 169 FFFCAALIAL 178
Cdd:cd17370   362 LALIALLLLL 371
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 31-178 8.13e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 36.64  E-value: 8.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  31 FILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRV-NRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIANVAGSF 109
Cdd:cd06174   230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175376632 110 FGPSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGITFFFCAALIAL 178
Cdd:cd06174   310 LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 38-180 8.69e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 36.37  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  38 SASAVAGIYIVGPVARLLTQFWAGSLIDR-VNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIanvagsFFGPSSTY 116
Cdd:cd17471    30 SPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVV------LLSLGAAA 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1175376632 117 Y---------VTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSLCIFINGITFFFCAALIALLP 180
Cdd:cd17471   104 FpqlfalareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLL 176
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 28-171 9.90e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 36.09  E-value: 9.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  28 LNIFILDMTGSASAVA---GIYIVGP-VARLLTQFWAGSLIDRVNRRKLMIYSDVARGALVLLIPLLSSVWVVYAILFIA 103
Cdd:cd17391   224 LTLYIRQLMGDASNLAfisGLVFSATgVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLL 303

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175376632 104 NVAGSFFGPSSTYYVTKLVTPEERRRF----NSIMSMLNAGAFLIGPAIAGVL-ISTT--GTSLCIFINGITFFF 171
Cdd:cd17391   304 GLATGGLLPAINSLLAKITPKEVAGRIfgynQSFQYLGNVAGPLLGSAIAAHFgYRAVfvVTALLVLLNAIWSFI 378
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-179 9.97e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 36.42  E-value: 9.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  13 GIGVSYLGNWIYLVALNIFILDMTGSASAVAGIYIVGPVARLLTQFWAGSLIDRVN-----RRKLMIYSDVARGALVLLI 87
Cdd:COG2211    19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175376632  88 PLLSS------VWVVYAILFIANVAGSFFG-PSSTYYVTKLVTPEERRRFNSIMSMLNAGAFLIGPAIAGVLISTTGTSL 160
Cdd:COG2211    99 FTAPDlsptgkLIYALVTYLLLGLAYTLVNiPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA 178

                         170
                  ....*....|....*....
gi 1175376632 161 cIFINGITFFFCAALIALL 179
Cdd:COG2211   179 -ALGYRLTALIFAVLGLLA 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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