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Conserved domains on  [gi|1176659078|ref|WP_082486059|]
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MULTISPECIES: HD-GYP domain-containing protein [unclassified Acidovorax]

Protein Classification

HD-GYP domain-containing protein( domain architecture ID 12112208)

HD-GYP domain-containing protein may be a phosphodiesterase; also contains a DUF3391 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 82-338 3.24e-80

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


:

Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 249.50  E-value: 3.24e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078  82 VAVPVDRPRAARPAGASAGADPRRAERLAAQARDAVRALFVQARAGQAICLDHSLAIVDELAALVAsqpgaLVGLARLKS 161
Cdd:COG2206    65 LLLLLLLLLLLLSLLLAVALLLAELLLLLAALESLLAELFEELRLGLLEELKKLVEELDELLPDAL-----LALLAALDA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 162 KDDYTFAHSVAVCTLMIALARQIGMGPDQVREAGMCGLLHDVGKLLVPRHILDKPGKLTPEEFGVMQRHPQQGVDILRRG 241
Cdd:COG2206   140 KDPYTYGHSVRVAVLALALARELGLSEEELEDLGLAALLHDIGKIGIPDEILNKPGKLTDEEFEIIKKHPEYGYEILKKL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 242 GHVPDtVIDVCLHHHEKLDGSGYPHGLARGQISLLARMAAVCDVYDAVTSERAYKNAWDPAMALARMAQWEG-HFDPSVL 320
Cdd:COG2206   220 PGLSE-VAEIVLQHHERLDGSGYPRGLKGEEIPLLARILAVADVYDALTSDRPYRKALSPEEALEELRKGAGtQFDPELV 298

                         250
                  ....*....|....*...
gi 1176659078 321 HAFVRVVGIYPVGSLVRL 338
Cdd:COG2206   299 EAFIKVLGIYPPVVEIDL 316
DUF3391 pfam11871
Domain of unknown function (DUF3391); This functionally uncharacterized, N-terminal domain is ...
 2-130 4.46e-29

Domain of unknown function (DUF3391); This functionally uncharacterized, N-terminal domain is found in a number of bacterial proteins, including Cyclic di-GMP phosphodiesterase PA4108. It is often found associated with the HD domain pfam13328.


:

Pssm-ID: 432148  Cd Length: 136  Bit Score: 110.21  E-value: 4.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078   2 LKRISVEQAAPGMFVHALDAPWVSHPFWCSRFTLHSADDVRSLRQSGVAHCWIDVSRGAD--VAAGAAPGAELPSTPAQP 79
Cdd:pfam11871   1 LKKIPVDQLRPGMFVVKLDGSWLDHPFLRNRFLIKSEEDIEKLRALGIKEVWIDTERSDVppLPGLDVPAAEAAAAAEAA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1176659078  80 GPVAVPVDRPRAARPAGASAGADPRRAERLAAQARDAVRALFVQARAGQAI 130
Cdd:pfam11871  81 EEPAALTEEKQERPERLEARREELARAEKLYEEAKALVRSLFSDARLGKAI 131
 
Name Accession Description Interval E-value
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 82-338 3.24e-80

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 249.50  E-value: 3.24e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078  82 VAVPVDRPRAARPAGASAGADPRRAERLAAQARDAVRALFVQARAGQAICLDHSLAIVDELAALVAsqpgaLVGLARLKS 161
Cdd:COG2206    65 LLLLLLLLLLLLSLLLAVALLLAELLLLLAALESLLAELFEELRLGLLEELKKLVEELDELLPDAL-----LALLAALDA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 162 KDDYTFAHSVAVCTLMIALARQIGMGPDQVREAGMCGLLHDVGKLLVPRHILDKPGKLTPEEFGVMQRHPQQGVDILRRG 241
Cdd:COG2206   140 KDPYTYGHSVRVAVLALALARELGLSEEELEDLGLAALLHDIGKIGIPDEILNKPGKLTDEEFEIIKKHPEYGYEILKKL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 242 GHVPDtVIDVCLHHHEKLDGSGYPHGLARGQISLLARMAAVCDVYDAVTSERAYKNAWDPAMALARMAQWEG-HFDPSVL 320
Cdd:COG2206   220 PGLSE-VAEIVLQHHERLDGSGYPRGLKGEEIPLLARILAVADVYDALTSDRPYRKALSPEEALEELRKGAGtQFDPELV 298

                         250
                  ....*....|....*...
gi 1176659078 321 HAFVRVVGIYPVGSLVRL 338
Cdd:COG2206   299 EAFIKVLGIYPPVVEIDL 316
DUF3391 pfam11871
Domain of unknown function (DUF3391); This functionally uncharacterized, N-terminal domain is ...
 2-130 4.46e-29

Domain of unknown function (DUF3391); This functionally uncharacterized, N-terminal domain is found in a number of bacterial proteins, including Cyclic di-GMP phosphodiesterase PA4108. It is often found associated with the HD domain pfam13328.


Pssm-ID: 432148  Cd Length: 136  Bit Score: 110.21  E-value: 4.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078   2 LKRISVEQAAPGMFVHALDAPWVSHPFWCSRFTLHSADDVRSLRQSGVAHCWIDVSRGAD--VAAGAAPGAELPSTPAQP 79
Cdd:pfam11871   1 LKKIPVDQLRPGMFVVKLDGSWLDHPFLRNRFLIKSEEDIEKLRALGIKEVWIDTERSDVppLPGLDVPAAEAAAAAEAA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1176659078  80 GPVAVPVDRPRAARPAGASAGADPRRAERLAAQARDAVRALFVQARAGQAI 130
Cdd:pfam11871  81 EEPAALTEEKQERPERLEARREELARAEKLYEEAKALVRSLFSDARLGKAI 131
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 164-297 1.26e-23

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 95.87  E-value: 1.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 164 DYTFAHSVAVCTLMIALARQIGMGPDQVREAGMCGLLHDVGKLLVPRHIldkpgklTPEEFGVMQRHPQQGVDILRRG-- 241
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELGLSEEDIELLRLAALLHDIGKPGTPDAI-------TEEESELEKDHAIVGAEILRELll 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 242 ----GHVPDTVIDVCLHHHEKLDGSGYPHGLARGQISLLARMAAVCDVYDAVTSERAYKN 297
Cdd:cd00077    74 eeviKLIDELILAVDASHHERLDGLGYPDGLKGEEITLEARIVKLADRLDALRRDSREKR 133
HD_5 pfam13487
HD domain; HD domains are metal dependent phosphohydrolases.
 217-279 4.17e-17

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 433249 [Multi-domain]  Cd Length: 64  Bit Score: 74.94  E-value: 4.17e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176659078 217 GKLTPEEFGVMQRHPQQGVDILRRGGHVPDTVIDVCLHHHEKLDGSGYPHGLARGQISLLARM 279
Cdd:pfam13487   1 GTLTPEEREIINRHPEHTARLLSTLPRLPKEVAEIIAQHHERLDGSGYPRGLKGEEIPLGARI 63
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 163-296 9.37e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 58.85  E-value: 9.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078  163 DDYTFAHSVAVCTLMIALARQigMGPDQVREAGMCGLLHDVGKLLVPRHILDKpgkltpeeFGVMQRHPQQGVDILRRGG 242
Cdd:smart00471   2 DYHVFEHSLRVAQLAAALAEE--LGLLDIELLLLAALLHDIGKPGTPDSFLVK--------TSVLEDHHFIGAEILLEEE 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1176659078  243 H---VPDTVIDVCLHHHEKLDGSGYPhglargQISLLARMAAVCDVYDAVTSERAYK 296
Cdd:smart00471  72 EpriLEEILRTAILSHHERPDGLRGE------PITLEARIVKVADRLDALRADRRYR 122
HDIG TIGR00277
HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number ...
 166-258 1.50e-06

HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number of uncharacterized proteins. It contains four widely separated His residues, the second of which is part of an invariant dipeptide His-Asp in a region matched approximately by the motif HDIG. This model may annotate homologous domains in which one or more of the His residues is conserved but misaligned, and some probable false-positive hits.


Pssm-ID: 272994 [Multi-domain]  Cd Length: 80  Bit Score: 45.79  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 166 TFAHSVAVCTLMIALARQIGMGPDQVREagmCGLLHDVGKLLVPRHILDKpgkltpeefgvmqRHPQQGVDILRRGGhVP 245
Cdd:TIGR00277   5 VLQHSLEVAKLAEALARELGLDVELARR---GALLHDIGKPITREGVIFE-------------SHVVVGAEIARKYG-EP 67

                          90
                  ....*....|...
gi 1176659078 246 DTVIDVCLHHHEK 258
Cdd:TIGR00277  68 LEVIDIIAEHHGK 80
PRK12705 PRK12705
hypothetical protein; Provisional
 102-261 8.27e-06

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 47.78  E-value: 8.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 102 DPRRAERLAAQARDAVRAlFVQARAGQAIcldHSLAIVDelaalvaSQPGALVGLARLKSKDDY---TFAHSVAVCTLMI 178
Cdd:PRK12705  268 HPARIEEYVQKANEEFKQ-KIYEIGEEVL---EELGIFD-------LKPGLVRLLGRLYFRTSYgqnVLSHSLEVAHLAG 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 179 ALARQIGMGPDQVREagmCGLLHDVGKllvprhILDKPGKLTpeefgvmqrHPQQGVDILRRGGHvPDTVIDVCLHHHEK 258
Cdd:PRK12705  337 IIAAEIGLDPALAKR---AGLLHDIGK------SIDRESDGN---------HVEIGAELARKFNE-PDEVINAIASHHNK 397


                  ...
gi 1176659078 259 LDG 261
Cdd:PRK12705  398 VNP 400
 
Name Accession Description Interval E-value
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 82-338 3.24e-80

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 249.50  E-value: 3.24e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078  82 VAVPVDRPRAARPAGASAGADPRRAERLAAQARDAVRALFVQARAGQAICLDHSLAIVDELAALVAsqpgaLVGLARLKS 161
Cdd:COG2206    65 LLLLLLLLLLLLSLLLAVALLLAELLLLLAALESLLAELFEELRLGLLEELKKLVEELDELLPDAL-----LALLAALDA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 162 KDDYTFAHSVAVCTLMIALARQIGMGPDQVREAGMCGLLHDVGKLLVPRHILDKPGKLTPEEFGVMQRHPQQGVDILRRG 241
Cdd:COG2206   140 KDPYTYGHSVRVAVLALALARELGLSEEELEDLGLAALLHDIGKIGIPDEILNKPGKLTDEEFEIIKKHPEYGYEILKKL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 242 GHVPDtVIDVCLHHHEKLDGSGYPHGLARGQISLLARMAAVCDVYDAVTSERAYKNAWDPAMALARMAQWEG-HFDPSVL 320
Cdd:COG2206   220 PGLSE-VAEIVLQHHERLDGSGYPRGLKGEEIPLLARILAVADVYDALTSDRPYRKALSPEEALEELRKGAGtQFDPELV 298

                         250
                  ....*....|....*...
gi 1176659078 321 HAFVRVVGIYPVGSLVRL 338
Cdd:COG2206   299 EAFIKVLGIYPPVVEIDL 316
DUF3391 pfam11871
Domain of unknown function (DUF3391); This functionally uncharacterized, N-terminal domain is ...
 2-130 4.46e-29

Domain of unknown function (DUF3391); This functionally uncharacterized, N-terminal domain is found in a number of bacterial proteins, including Cyclic di-GMP phosphodiesterase PA4108. It is often found associated with the HD domain pfam13328.


Pssm-ID: 432148  Cd Length: 136  Bit Score: 110.21  E-value: 4.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078   2 LKRISVEQAAPGMFVHALDAPWVSHPFWCSRFTLHSADDVRSLRQSGVAHCWIDVSRGAD--VAAGAAPGAELPSTPAQP 79
Cdd:pfam11871   1 LKKIPVDQLRPGMFVVKLDGSWLDHPFLRNRFLIKSEEDIEKLRALGIKEVWIDTERSDVppLPGLDVPAAEAAAAAEAA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1176659078  80 GPVAVPVDRPRAARPAGASAGADPRRAERLAAQARDAVRALFVQARAGQAI 130
Cdd:pfam11871  81 EEPAALTEEKQERPERLEARREELARAEKLYEEAKALVRSLFSDARLGKAI 131
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 164-297 1.26e-23

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 95.87  E-value: 1.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 164 DYTFAHSVAVCTLMIALARQIGMGPDQVREAGMCGLLHDVGKLLVPRHIldkpgklTPEEFGVMQRHPQQGVDILRRG-- 241
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELGLSEEDIELLRLAALLHDIGKPGTPDAI-------TEEESELEKDHAIVGAEILRELll 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 242 ----GHVPDTVIDVCLHHHEKLDGSGYPHGLARGQISLLARMAAVCDVYDAVTSERAYKN 297
Cdd:cd00077    74 eeviKLIDELILAVDASHHERLDGLGYPDGLKGEEITLEARIVKLADRLDALRRDSREKR 133
HD_5 pfam13487
HD domain; HD domains are metal dependent phosphohydrolases.
 217-279 4.17e-17

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 433249 [Multi-domain]  Cd Length: 64  Bit Score: 74.94  E-value: 4.17e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176659078 217 GKLTPEEFGVMQRHPQQGVDILRRGGHVPDTVIDVCLHHHEKLDGSGYPHGLARGQISLLARM 279
Cdd:pfam13487   1 GTLTPEEREIINRHPEHTARLLSTLPRLPKEVAEIIAQHHERLDGSGYPRGLKGEEIPLGARI 63
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 177-263 9.52e-13

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 67.11  E-value: 9.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 177 MIALARQIGMGPDQVREAGMCGLLHDVGKLLVPRHILDKPGKLTPEEFGVMQRHPQQGVDILRrgghvPDTVIDVCLHHH 256
Cdd:COG3437   123 ALELRRLQRELDDLVLYLKLAAPLHDIGKIGIPDAILLKPGKLTPEEWEITHAHIGAEILSGS-----LLPLLQLAAEIH 197


                  ....*..
gi 1176659078 257 EKLDGSG 263
Cdd:COG3437   198 ERWDGSG 204
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
 166-288 7.15e-11

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 58.79  E-value: 7.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 166 TFAHSVAVCTLMIALARQIGmgPDQVREAGMCGLLHDVGKLLVPRHIldkpgkltpEEFGVMQRHPQQGVDILRRGGHVP 245
Cdd:pfam01966   1 RLEHSLRVALLARELAEELG--ELDRELLLLAALLHDIGKGPFGDEK---------PEFEIFLGHAVVGAEILRELEKRL 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1176659078 246 --DTVIDVCLHHHEKLDGSGYPhglarGQISLLARMAAVCDVYDA 288
Cdd:pfam01966  70 glEDVLKLILEHHESWEGAGYP-----EEISLEARIVKLADRLDA 109
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 163-296 9.37e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 58.85  E-value: 9.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078  163 DDYTFAHSVAVCTLMIALARQigMGPDQVREAGMCGLLHDVGKLLVPRHILDKpgkltpeeFGVMQRHPQQGVDILRRGG 242
Cdd:smart00471   2 DYHVFEHSLRVAQLAAALAEE--LGLLDIELLLLAALLHDIGKPGTPDSFLVK--------TSVLEDHHFIGAEILLEEE 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1176659078  243 H---VPDTVIDVCLHHHEKLDGSGYPhglargQISLLARMAAVCDVYDAVTSERAYK 296
Cdd:smart00471  72 EpriLEEILRTAILSHHERPDGLRGE------PITLEARIVKVADRLDALRADRRYR 122
HDIG TIGR00277
HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number ...
 166-258 1.50e-06

HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number of uncharacterized proteins. It contains four widely separated His residues, the second of which is part of an invariant dipeptide His-Asp in a region matched approximately by the motif HDIG. This model may annotate homologous domains in which one or more of the His residues is conserved but misaligned, and some probable false-positive hits.


Pssm-ID: 272994 [Multi-domain]  Cd Length: 80  Bit Score: 45.79  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 166 TFAHSVAVCTLMIALARQIGMGPDQVREagmCGLLHDVGKLLVPRHILDKpgkltpeefgvmqRHPQQGVDILRRGGhVP 245
Cdd:TIGR00277   5 VLQHSLEVAKLAEALARELGLDVELARR---GALLHDIGKPITREGVIFE-------------SHVVVGAEIARKYG-EP 67

                          90
                  ....*....|...
gi 1176659078 246 DTVIDVCLHHHEK 258
Cdd:TIGR00277  68 LEVIDIIAEHHGK 80
PRK12705 PRK12705
hypothetical protein; Provisional
 102-261 8.27e-06

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 47.78  E-value: 8.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 102 DPRRAERLAAQARDAVRAlFVQARAGQAIcldHSLAIVDelaalvaSQPGALVGLARLKSKDDY---TFAHSVAVCTLMI 178
Cdd:PRK12705  268 HPARIEEYVQKANEEFKQ-KIYEIGEEVL---EELGIFD-------LKPGLVRLLGRLYFRTSYgqnVLSHSLEVAHLAG 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 179 ALARQIGMGPDQVREagmCGLLHDVGKllvprhILDKPGKLTpeefgvmqrHPQQGVDILRRGGHvPDTVIDVCLHHHEK 258
Cdd:PRK12705  337 IIAAEIGLDPALAKR---AGLLHDIGK------SIDRESDGN---------HVEIGAELARKFNE-PDEVINAIASHHNK 397


                  ...
gi 1176659078 259 LDG 261
Cdd:PRK12705  398 VNP 400
HDOD pfam08668
HDOD domain;
169-257 2.44e-04

HDOD domain;


Pssm-ID: 430141 [Multi-domain]  Cd Length: 196  Bit Score: 41.83  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 169 HSVAVCTLMIALARQIGMgpDQVREAGMCGLLHDVGKLLVPRHILDKPGKL------TPEEFGVMQR------HPQQGVD 236
Cdd:pfam08668  98 HSLACALAARLLARRLGL--DDPEEAFLAGLLHDIGKLILLSLLPDKYEELlekaaeEGISLLEAERellgtdHAEVGAA 175

                          90       100
                  ....*....|....*....|.
gi 1176659078 237 ILRRgGHVPDTVIDVCLHHHE 257
Cdd:pfam08668 176 LLER-WNLPEELVEAIAYHHN 195
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
58-117 2.74e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.83  E-value: 2.74e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176659078  58 RGADVAAGAAPGAELPSTPAQPGP-VAVPVDRPRAARPAGASAGADPRRAERlAAQARDAV 117
Cdd:PRK07003  567 RGARAAAAAKPAAAPAAAPKPAAPrVAVQVPTPRARAATGDAPPNGAARAEQ-AAESRGAP 626
PRK12704 PRK12704
phosphodiesterase; Provisional
 153-257 5.26e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 38.99  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 153 LVGlaRLKSKDDYT---FAHSVAVCTLMIALARQIGMGPDQVREAGmcgLLHDVGKllVPRHILDKPgkltpeefgvmqr 229
Cdd:PRK12704  322 LLG--RLKYRTSYGqnvLQHSIEVAHLAGLMAAELGLDVKLAKRAG---LLHDIGK--ALDHEVEGS------------- 381

                          90       100
                  ....*....|....*....|....*...
gi 1176659078 230 HPQQGVDILRRGGHvPDTVIDVCLHHHE 257
Cdd:PRK12704  382 HVEIGAELAKKYKE-SPVVINAIAAHHG 408
HDOD COG1639
HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];
144-257 7.36e-03

HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];


Pssm-ID: 441246 [Multi-domain]  Cd Length: 244  Bit Score: 37.64  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176659078 144 ALVASQPGALVGLARLkskddytFAHSVAVCTLMIALARQIGMgpDQVREAGMCGLLHDVGKLLV----PRHILD----- 214
Cdd:COG1639    90 LFSAKLPAYGLDLRRF-------WRHSLAVAAAARALARRLGL--LDPEEAFLAGLLHDIGKLVLlslfPEEYAEllala 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1176659078 215 KPGKLTPEE-----FGVmqRHPQQGVDILRRgGHVPDTVIDVCLHHHE 257
Cdd:COG1639   161 EADGLSLAEaerevLGT--DHAELGAALARK-WGLPEELVEAIRYHHD 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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