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Conserved domains on  [gi|1177212646|ref|WP_082636892|]
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MULTISPECIES: GFA family protein [Citrobacter]

Protein Classification

GFA family protein( domain architecture ID 10007990)

GFA family protein similar to bacterial glutathione-dependent formaldehyde-activating enzyme, which catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione, and to eukaryotic centromere protein V, which plays a role in the distribution of pericentromeric heterochromatin in interphase nuclei

CATH:  2.170.150.70
Gene Ontology:  GO:0016846|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
1-106 6.63e-32

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443005  Cd Length: 132  Bit Score: 109.72  E-value: 6.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177212646   1 MMTkkYSAQCHCGAVTFTVQLSdgFHTVRRCNCSFCRMRG----AVVVSAPLDGIDVLTGRDKLTEYRFnTGEAKHYFCS 76
Cdd:COG3791     1 MMT--LTGSCLCGAVRFEVDGP--PLRVGACHCSICRKATgsafAAVALVPADAFRLTSGEDALTTYRS-SATAERHFCP 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1177212646  77 VCGIYTFHQRRSSPDQYGVNVACIEDVSPF 106
Cdd:COG3791    76 TCGSPLFYRRRGGPGLVAVNAGLLDDPDGL 105
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
1-106 6.63e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 109.72  E-value: 6.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177212646   1 MMTkkYSAQCHCGAVTFTVQLSdgFHTVRRCNCSFCRMRG----AVVVSAPLDGIDVLTGRDKLTEYRFnTGEAKHYFCS 76
Cdd:COG3791     1 MMT--LTGSCLCGAVRFEVDGP--PLRVGACHCSICRKATgsafAAVALVPADAFRLTSGEDALTTYRS-SATAERHFCP 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1177212646  77 VCGIYTFHQRRSSPDQYGVNVACIEDVSPF 106
Cdd:COG3791    76 TCGSPLFYRRRGGPGLVAVNAGLLDDPDGL 105
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 29-106 6.30e-07

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 44.66  E-value: 6.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177212646  29 RRCNCSFCRMR----GAVVVSAPLDGIDVLTGRDKLTEYRFNTGEA-KHYFCSVCGIYTFHQRRSSPDQYGVNVACIEDV 103
Cdd:pfam04828   1 YLCHCRDCQRRsgsaFAANAVVPKEALRLTSGELKEYTDTGDSGNTvTRYFCPNCGTPLYSESTAAPGVIIVRVGTLDDP 80


                  ...
gi 1177212646 104 SPF 106
Cdd:pfam04828  81 DQL 83
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
1-106 6.63e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 109.72  E-value: 6.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177212646   1 MMTkkYSAQCHCGAVTFTVQLSdgFHTVRRCNCSFCRMRG----AVVVSAPLDGIDVLTGRDKLTEYRFnTGEAKHYFCS 76
Cdd:COG3791     1 MMT--LTGSCLCGAVRFEVDGP--PLRVGACHCSICRKATgsafAAVALVPADAFRLTSGEDALTTYRS-SATAERHFCP 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1177212646  77 VCGIYTFHQRRSSPDQYGVNVACIEDVSPF 106
Cdd:COG3791    76 TCGSPLFYRRRGGPGLVAVNAGLLDDPDGL 105
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 29-106 6.30e-07

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 44.66  E-value: 6.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177212646  29 RRCNCSFCRMR----GAVVVSAPLDGIDVLTGRDKLTEYRFNTGEA-KHYFCSVCGIYTFHQRRSSPDQYGVNVACIEDV 103
Cdd:pfam04828   1 YLCHCRDCQRRsgsaFAANAVVPKEALRLTSGELKEYTDTGDSGNTvTRYFCPNCGTPLYSESTAAPGVIIVRVGTLDDP 80


                  ...
gi 1177212646 104 SPF 106
Cdd:pfam04828  81 DQL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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