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Conserved domains on  [gi|1178481238|ref|WP_083003074|]
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low molecular weight protein-tyrosine-phosphatase [Pasteurella multocida]

Protein Classification

low molecular weight protein-tyrosine-phosphatase( domain architecture ID 11611401)

low molecular weight protein-tyrosine-phosphatase is a small soluble single-domain enzyme that catalyzes the dephosphorylation of O-phosphotyrosine groups in phosphoproteins

EC:  3.1.3.48
Gene Ontology:  GO:0004725|GO:0006470
PubMed:  12678841|12882518|27676368
SCOP:  4000436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 5-143 7.75e-56

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


:

Pssm-ID: 319971  Cd Length: 147  Bit Score: 171.47  E-value: 7.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEKN-----ITSAGLVTERsrlVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCHK 79
Cdd:cd16343     3 ILFVCLGNICRSPMAEAVLRHLLPKAGgddveVDSAGTSAWH---GGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1178481238  80 ADLILVMENPHIELVHQLCPL-SQGKVMLFGH-GLTASKEIPDPYKKSQEMFEYAYQMLDSAAYQW 143
Cdd:cd16343    80 FDLILAMDESNLRDLRRLAPAeARGKVFLLGDfDPEGGKDVPDPYYGGREGFEEVYDLIERACEGL 145
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 5-143 7.75e-56

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 171.47  E-value: 7.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEKN-----ITSAGLVTERsrlVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCHK 79
Cdd:cd16343     3 ILFVCLGNICRSPMAEAVLRHLLPKAGgddveVDSAGTSAWH---GGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1178481238  80 ADLILVMENPHIELVHQLCPL-SQGKVMLFGH-GLTASKEIPDPYKKSQEMFEYAYQMLDSAAYQW 143
Cdd:cd16343    80 FDLILAMDESNLRDLRRLAPAeARGKVFLLGDfDPEGGKDVPDPYYGGREGFEEVYDLIERACEGL 145
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
1-147 8.87e-54

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 166.24  E-value: 8.87e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   1 MFEQILVVCMGNICRSPVGEKLLQRYFPEKNITSAGLvterSRLVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCHKA 80
Cdd:PRK10126    1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGL----GALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNY 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1178481238  81 DLILVMENPHIELVHQLCPLSQGKVMLFGHgLTASKEIPDPYKKSQEMFEYAYQMLDSAAYQWKKML 147
Cdd:PRK10126   77 DLILTMEKRHIERLCEMAPEMRGKVMLFGH-WDNECEIPDPYRKSREAFEAVYTLLERSARQWAQAL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-147 9.42e-39

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 127.97  E-value: 9.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   1 MFEQILVVCMGNICRSPVGEKLLQRYFPEK-NITSAGlvTERSrlvdKPADDMMIKIASQHGLNLSTHRAKQLTRALCHK 79
Cdd:COG0394     2 MPKRVLFVCTGNICRSPMAEALLRHLAGGRvEVDSAG--TEPG----GPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1178481238  80 ADLILVMENPHIElvhQLCPLSQGKVMLFGHgltasKEIPDPYKKSQEMFEYAYQMLDSAAYQWKKML 147
Cdd:COG0394    76 FDLVITMCDSAAE---ELCPLFPGAAKLLLH-----WDVPDPYYGGLEAFREVRDEIERRIEALLAKL 135
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
5-143 3.63e-36

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 121.33  E-value: 3.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEKN------ITSAGLvterSRLVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCH 78
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGlgdkveVDSAGT----GAWPGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1178481238  79 KADLILVMENPHIElvhQLCPL----SQGKVMLFGHgLTASKEIPDPYKKSQEMFEYAYQMLDSAAYQW 143
Cdd:pfam01451  77 SFDLILAMDSEHKR---DLCPLaperYRAKVMLLGE-YGEQLDIPDPYYGSIDAFEEVRDLIERRCRQL 141
LMWPc smart00226
Low molecular weight phosphatase family;
5-145 1.55e-33

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 114.49  E-value: 1.55e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238    5 ILVVCMGNICRSPVGEKLLQRYFP-EKNITSAGLvterSRLVDKPADDMMIKIASQHGLNLStHRAKQLTRALCHKADLI 83
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGdRVKIDSAGT----GAWVGGGADPRAVKVLKEHGIDLS-HHASQLTSSDFKNADLV 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1178481238   84 LVMENPHIELVHQLCPLSQGKVMLFGHgltaSKEIPDPYKKSQEMFEYAYQMLDSAAYQWKK 145
Cdd:smart00226  76 LAMDGSHLRNICRLKPPSRAKVELFGH----YVDVDDPYYGGIDGFERVYDELENALQEFLK 133
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 5-143 7.75e-56

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 171.47  E-value: 7.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEKN-----ITSAGLVTERsrlVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCHK 79
Cdd:cd16343     3 ILFVCLGNICRSPMAEAVLRHLLPKAGgddveVDSAGTSAWH---GGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1178481238  80 ADLILVMENPHIELVHQLCPL-SQGKVMLFGH-GLTASKEIPDPYKKSQEMFEYAYQMLDSAAYQW 143
Cdd:cd16343    80 FDLILAMDESNLRDLRRLAPAeARGKVFLLGDfDPEGGKDVPDPYYGGREGFEEVYDLIERACEGL 145
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
1-147 8.87e-54

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 166.24  E-value: 8.87e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   1 MFEQILVVCMGNICRSPVGEKLLQRYFPEKNITSAGLvterSRLVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCHKA 80
Cdd:PRK10126    1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGL----GALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNY 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1178481238  81 DLILVMENPHIELVHQLCPLSQGKVMLFGHgLTASKEIPDPYKKSQEMFEYAYQMLDSAAYQWKKML 147
Cdd:PRK10126   77 DLILTMEKRHIERLCEMAPEMRGKVMLFGH-WDNECEIPDPYRKSREAFEAVYTLLERSARQWAQAL 142
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 1-147 6.84e-47

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 149.01  E-value: 6.84e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   1 MFEQILVVCMGNICRSPVGEKLLQRYFPEKNITSAGLvterSRLVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCHKA 80
Cdd:PRK11391    1 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGV----HGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNY 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1178481238  81 DLILVMENPHIELVHQLCPLSQGKVMLFGHGLTaSKEIPDPYKKSQEMFEYAYQMLDSAAYQWKKML 147
Cdd:PRK11391   77 DLILAMESEHIAQVTAIAPEVRGKTMLFGQWLE-QKEIPDPYRKSQDAFEHVYGMLERASQEWAKRL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-147 9.42e-39

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 127.97  E-value: 9.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   1 MFEQILVVCMGNICRSPVGEKLLQRYFPEK-NITSAGlvTERSrlvdKPADDMMIKIASQHGLNLSTHRAKQLTRALCHK 79
Cdd:COG0394     2 MPKRVLFVCTGNICRSPMAEALLRHLAGGRvEVDSAG--TEPG----GPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1178481238  80 ADLILVMENPHIElvhQLCPLSQGKVMLFGHgltasKEIPDPYKKSQEMFEYAYQMLDSAAYQWKKML 147
Cdd:COG0394    76 FDLVITMCDSAAE---ELCPLFPGAAKLLLH-----WDVPDPYYGGLEAFREVRDEIERRIEALLAKL 135
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
5-143 3.63e-36

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 121.33  E-value: 3.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEKN------ITSAGLvterSRLVDKPADDMMIKIASQHGLNLSTHRAKQLTRALCH 78
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGlgdkveVDSAGT----GAWPGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1178481238  79 KADLILVMENPHIElvhQLCPL----SQGKVMLFGHgLTASKEIPDPYKKSQEMFEYAYQMLDSAAYQW 143
Cdd:pfam01451  77 SFDLILAMDSEHKR---DLCPLaperYRAKVMLLGE-YGEQLDIPDPYYGSIDAFEEVRDLIERRCRQL 141
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 5-145 3.39e-35

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 118.75  E-value: 3.39e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEKN-ITSAGLvterSRLVDKPADDMMIKIASQHGLNLStHRAKQLTRALCHKADLI 83
Cdd:cd00115     2 ILFICTGNICRSPMAEAIFKQLLGDEWkVDSAGT----GAHHGEGADPRAVRVLKEVGIDIS-HRSDQIKSEHLDNYDLV 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1178481238  84 LVMENPHIELVHQLCPLSQGKVMLFGHGLTaSKEIPDPYKKSQEMFEYAYQMLDSAAYQWKK 145
Cdd:cd00115    77 LVMDGSNLDKIPRIFPEARGKTWLPHVKLE-HGEIDDPYRGDIEDFRRVRDELENASKRFAE 137
LMWPc smart00226
Low molecular weight phosphatase family;
5-145 1.55e-33

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 114.49  E-value: 1.55e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238    5 ILVVCMGNICRSPVGEKLLQRYFP-EKNITSAGLvterSRLVDKPADDMMIKIASQHGLNLStHRAKQLTRALCHKADLI 83
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGdRVKIDSAGT----GAWVGGGADPRAVKVLKEHGIDLS-HHASQLTSSDFKNADLV 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1178481238   84 LVMENPHIELVHQLCPLSQGKVMLFGHgltaSKEIPDPYKKSQEMFEYAYQMLDSAAYQWKK 145
Cdd:smart00226  76 LAMDGSHLRNICRLKPPSRAKVELFGH----YVDVDDPYYGGIDGFERVYDELENALQEFLK 133
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 5-139 2.08e-28

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 101.74  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEKNIT--SAGLVTersrlVDK-PADDMMIKIASQHGLNLSTHRAKQLTRALCHKAD 81
Cdd:cd16344     3 ILFVCTGNTCRSPMAEAILKKLLEELDVEvkSAGIFA-----VDGsPASPNAVEVLKEKGIDLSGHRSQQLTEELLEWAD 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1178481238  82 LILVMENPHIELVHQLCPLSQGKVMLFGH-GLTASKEIPDPYKKSQEMFEYAYQMLDSA 139
Cdd:cd16344    78 LILTMTESHKQALLSLYPEAADKVFTLKEyVGGEDGDISDPFGGSLEVYRQTAEELEEL 136
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 5-124 1.54e-06

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 44.75  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178481238   5 ILVVCMGNICRSPVGEKLLQRYFPEK-NITSAGLvtersrlvdKPA--DDMMIKIASQHGLNLSTHRAKQLTRALCHKAD 81
Cdd:cd16345     2 VLFLCTGNSARSQMAEALLRHLGGDRfEAYSAGS---------EPAgvNPLAIEVMKEIGIDISGQRSKSLDEFLGQEFD 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1178481238  82 LILVM-ENphielVHQLCPlsqgkvMLFGHGLTASKEIPDPYKK 124
Cdd:cd16345    73 YVITVcDN-----AAEVCP------VFPGAVKRLHWGFPDPAAA 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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