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Conserved domains on  [gi|1180278855|ref|WP_083797660|]
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MULTISPECIES: TolC family protein [Marinobacter]

Protein Classification

TolC family protein( domain architecture ID 11446113)

TolC family protein is an outer membrane efflux protein that participates in type I protein secretion

CATH:  1.20.1600.10
Gene Ontology:  GO:0015562|GO:0055085
PubMed:  10092468
SCOP:  4003096
TCDB:  1.B.17

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
21-133 3.93e-19

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 82.01  E-value: 3.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:COG1538   252 DGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVL 331

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMGG 133
Cdd:COG1538   332 DAQRELLQAQLNLIQARYDYLLALVQLYRALGG 364
 
Name Accession Description Interval E-value
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
21-133 3.93e-19

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 82.01  E-value: 3.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:COG1538   252 DGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVL 331

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMGG 133
Cdd:COG1538   332 DAQRELLQAQLNLIQARYDYLLALVQLYRALGG 364
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
23-133 1.54e-18

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 80.69  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  23 GRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVLDA 102
Cdd:PRK09837  347 GRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLASLQITLQRARALYQHGAVSYLEVLDA 426

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1180278855 103 ERRWFTTELDLVATKRDRLRSMVNLYRAMGG 133
Cdd:PRK09837  427 ERSLFATRQTLLDLNYARQVNEISLFTALGG 457
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
 21-133 4.04e-16

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 73.99  E-value: 4.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:TIGR01845 347 DGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVL 426

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMGG 133
Cdd:TIGR01845 427 EAQRSLLTAQRSLATLQARRLSDSVALYKALGG 459
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 21-132 2.03e-11

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 58.69  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:pfam02321  70 DGGKRRARVKAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVL 149

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMG 132
Cdd:pfam02321 150 QAEVELLEARLELLNAEADLELALAQLEQLLG 181
 
Name Accession Description Interval E-value
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
21-133 3.93e-19

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 82.01  E-value: 3.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:COG1538   252 DGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVL 331

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMGG 133
Cdd:COG1538   332 DAQRELLQAQLNLIQARYDYLLALVQLYRALGG 364
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
23-133 1.54e-18

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 80.69  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  23 GRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVLDA 102
Cdd:PRK09837  347 GRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLASLQITLQRARALYQHGAVSYLEVLDA 426

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1180278855 103 ERRWFTTELDLVATKRDRLRSMVNLYRAMGG 133
Cdd:PRK09837  427 ERSLFATRQTLLDLNYARQVNEISLFTALGG 457
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
 21-133 4.04e-16

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 73.99  E-value: 4.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:TIGR01845 347 DGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVL 426

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMGG 133
Cdd:TIGR01845 427 EAQRSLLTAQRSLATLQARRLSDSVALYKALGG 459
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 21-132 2.03e-11

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 58.69  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:pfam02321  70 DGGKRRARVKAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVL 149

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMG 132
Cdd:pfam02321 150 QAEVELLEARLELLNAEADLELALAQLEQLLG 181
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
21-132 2.13e-08

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 51.58  E-value: 2.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:COG1538    45 LGGKRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVL 124

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1180278855 101 DAERRWFTTELDLVATKRDRLRSMVNLYRAMG 132
Cdd:COG1538   125 QAEAQLAQARAQLAQAEAQLAQARNALALLLG 156
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
 21-134 3.06e-07

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 48.14  E-value: 3.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  21 DFGRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVL 100
Cdd:TIGR01844  82 DGGSTWNAVRAAEAAALAARETLRATAQDLILRTAEAYMEVLRAQEILALAEANLAALKEQLDLARARFDVGLGTRTDVL 161

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1180278855 101 DAERRWFTTELDLVATkRDRLRSMVNLYRAMGGV 134
Cdd:TIGR01844 162 QAEARYASARAQLIQA-QNNLDDAKAQLRRLVGQ 194
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
 23-132 3.99e-07

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 48.14  E-value: 3.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180278855  23 GRAEALVNQAEARQRQALIAYRQAIQTVFQEVLDALVGLRGSDECLQTRARQVAALRNTTERARLRFEGGASSYPEVLDA 102
Cdd:TIGR01844 290 GATSAQVRQAAHQLNQSRSTLESQKRTVRQQVRNAWSNLNAAAASVQAYEQQVASAQKALDAYRQEYQVGTRTLLDVLNA 369

                          90       100       110
                  ....*....|....*....|....*....|
gi 1180278855 103 ERRWFTTELDLVATKRDRLRSMVNLYRAMG 132
Cdd:TIGR01844 370 EQELYQARQELANARYDYLQAQLNLLSATG 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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