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Conserved domains on  [gi|1180344225|ref|WP_083863025|]
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MULTISPECIES: (Fe-S)-binding protein [Mycobacterium]

Protein Classification

(Fe-S)-binding protein( domain architecture ID 11415541)

(Fe-S)-binding protein may function as an oxidoreductase

EC:  1.5.3.-
Gene Ontology:  GO:0046872|GO:0051536|GO:0016491
PubMed:  30942582

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 232-734 1.71e-88

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


:

Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 289.28  E-value: 1.71e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 232 KHMHIFTAPINVIFKRLPDGLGPLLPlehdgkPIDFENPPDDATFGRGKVEDF-----SWKAMLDFA-TCTECGRCQSQC 305
Cdd:COG0247    17 RFMAPFLELELGKIKYAFDPDNKLNP------GKIGLLNPGVELLGDGDLHDKnlktlPWKELLDALdACVGCGFCRAMC 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 306 PAWNT--GKPLSPKLVIMDLRDHwmakapyilgdkesslestpagglgeeLSGEEhaeahhvpesgfgrvmgsgpeqaar 383
Cdd:COG0247    91 PSYKAtgDEKDSPRGRINLLREV---------------------------LEGEL------------------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 384 PLVGTEEQggvidPDVLWSCVSCGACVEQCPVDIEHVDHIIDMRRYQVmmesefpselsvlfknlETKGNPWgqnasdRT 463
Cdd:COG0247   119 PLDLSEEV-----YEVLDLCLTCKACETACPSGVDIADLIAEARAQLV-----------------ERGGRPL------RD 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 464 NWIDEVDFDVPVYGEDvdsfdGYEYLFWVGCAGAYddKAKKTTKAVAELLAIAGVKYlVLGTGESCNGDSARRSGNEFLF 543
Cdd:COG0247   171 RLLRTFPDRVPAADKE-----GAEVLLFPGCFTNY--FDPEIGKAAVRLLEAAGVEV-VLPPEELCCGAPALSKGDLDLA 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 544 QQLAAQAVETLDGLfeGTEtvdrKIVVTCPHCFNTLGREYRQLGAN---YSVLHHTQLLNRLVRDNRLvPVTPVSQDITY 620
Cdd:COG0247   243 RKLARRNIEALERL--GVK----AIVTTCPSCGLTLKDEYPELLGDrvaFEVLDISEFLAELILEGKL-KLKPLGEKVTY 315

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 621 HDPCYLGRHNKVYEAPRELIGT-SGANLTEMPrhaERSFCCGAGGARMWMEEHIGKRINHERVDEALATGATTIATACPF 699
Cdd:COG0247   316 HDPCHLGRGGGVYDAPRELLKAiPGVEVVEMP---EDSGCCGGAGGYGFEEPELSMRIGERKLEQIRATGADVVVTACPS 392

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1180344225 700 CRVMVTDGVNDRqeeagrsGVEVLDVAQILLASLE 734
Cdd:COG0247   393 CRTQLEDGTKEY-------GIEVKHPVELLAEALG 420
 
Name Accession Description Interval E-value
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 232-734 1.71e-88

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 289.28  E-value: 1.71e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 232 KHMHIFTAPINVIFKRLPDGLGPLLPlehdgkPIDFENPPDDATFGRGKVEDF-----SWKAMLDFA-TCTECGRCQSQC 305
Cdd:COG0247    17 RFMAPFLELELGKIKYAFDPDNKLNP------GKIGLLNPGVELLGDGDLHDKnlktlPWKELLDALdACVGCGFCRAMC 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 306 PAWNT--GKPLSPKLVIMDLRDHwmakapyilgdkesslestpagglgeeLSGEEhaeahhvpesgfgrvmgsgpeqaar 383
Cdd:COG0247    91 PSYKAtgDEKDSPRGRINLLREV---------------------------LEGEL------------------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 384 PLVGTEEQggvidPDVLWSCVSCGACVEQCPVDIEHVDHIIDMRRYQVmmesefpselsvlfknlETKGNPWgqnasdRT 463
Cdd:COG0247   119 PLDLSEEV-----YEVLDLCLTCKACETACPSGVDIADLIAEARAQLV-----------------ERGGRPL------RD 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 464 NWIDEVDFDVPVYGEDvdsfdGYEYLFWVGCAGAYddKAKKTTKAVAELLAIAGVKYlVLGTGESCNGDSARRSGNEFLF 543
Cdd:COG0247   171 RLLRTFPDRVPAADKE-----GAEVLLFPGCFTNY--FDPEIGKAAVRLLEAAGVEV-VLPPEELCCGAPALSKGDLDLA 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 544 QQLAAQAVETLDGLfeGTEtvdrKIVVTCPHCFNTLGREYRQLGAN---YSVLHHTQLLNRLVRDNRLvPVTPVSQDITY 620
Cdd:COG0247   243 RKLARRNIEALERL--GVK----AIVTTCPSCGLTLKDEYPELLGDrvaFEVLDISEFLAELILEGKL-KLKPLGEKVTY 315

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 621 HDPCYLGRHNKVYEAPRELIGT-SGANLTEMPrhaERSFCCGAGGARMWMEEHIGKRINHERVDEALATGATTIATACPF 699
Cdd:COG0247   316 HDPCHLGRGGGVYDAPRELLKAiPGVEVVEMP---EDSGCCGGAGGYGFEEPELSMRIGERKLEQIRATGADVVVTACPS 392

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1180344225 700 CRVMVTDGVNDRqeeagrsGVEVLDVAQILLASLE 734
Cdd:COG0247   393 CRTQLEDGTKEY-------GIEVKHPVELLAEALG 420
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 400-730 4.61e-19

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 91.61  E-value: 4.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 400 LWSCVSCGACVEQCPVDIEHVDHIIDMRRyqvmmESEFPSELSvLFKNLETKGNPWGQNAS---DRTNWIDEVDfDVPVY 476
Cdd:PRK06259  184 LYNCTTCGKCVEVCPKEIDIPGKAIEKLR-----ALAFKKGLG-LPAHLEVRENVLKTGRSvpkEKPSFLEEVS-DIYPY 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 477 GEDvdsfdGYEYLFWVGCAgaYDDKAKKTTKAVAELLAIAGVKyLVLGTGESCNGDSARRSGNEFLFQQLAAQAVETLDG 556
Cdd:PRK06259  257 GNE-----KLRVAFFTGCL--VDYRLQEVGKDAIRVLNAHGIS-VIIPKNQVCCGSPLIRTGQTDVAEELKKKNLEIFNK 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 557 LfegtetvDRKIVVT-CPHCFNTLGREYRQlgANYSVLHHTQLLNRLvrdnRLVPVTPVSQDITYHDPCYLGRHNKVYEA 635
Cdd:PRK06259  329 L-------DVDTVVTiCAGCGSTLKNDYKE--KEFNVMDITEVLVEV----GLEKYKPLDITVTYHDPCHLRRGQGIYEE 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 636 PRELIgTSGANLT--EMPRHAErsfCCGAGG----ARMWMEEHIGKRinheRVDEALATGATTIATACPFCRVMVTDGVN 709
Cdd:PRK06259  396 PRKIL-RSIPGLEfvEMEIPDQ---CCGAGGgvrsGKPEIAEALGKR----KAEMIRETGADYVITVCPFCEYHIRDSLK 467

                         330       340
                  ....*....|....*....|.
gi 1180344225 710 drqeeAGRSGVEVLDVAQILL 730
Cdd:PRK06259  468 -----KYSEDIPVMNIVSLLD 483
CCG pfam02754
Cysteine-rich domain; The key element of this family is the CX31-38CCX33-34CXXC sequence motif ...
 618-704 1.81e-13

Cysteine-rich domain; The key element of this family is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins. There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster. The family includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase and glycerol-3-phosphate dehydrogenase.


Pssm-ID: 397052 [Multi-domain]  Cd Length: 84  Bit Score: 66.57  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 618 ITYHDPCYLGRHnkVYEAPRELIG-TSGANLTEMPRHaERSFCCGAGGARMWMEEhIGKRINHERVDEALATGATTIATA 696
Cdd:pfam02754   1 VAYFDGCHLGRA--LYPEPRKALKkVLGALGVEVVIL-EKQSCCGAGGGFSGKED-VAEALAKRNIDTAEETGADAIVTA 76


                  ....*...
gi 1180344225 697 CPFCRVMV 704
Cdd:pfam02754  77 CPGCLLQL 84
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 394-425 1.35e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 39.69  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1180344225 394 VIDPDVlwsCVSCGACVEQCPVD-IEHVD---HIID 425
Cdd:cd10549    74 EIDEEK---CIGCGLCVKVCPVDaITLEDeleIVID 106
 
Name Accession Description Interval E-value
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 232-734 1.71e-88

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 289.28  E-value: 1.71e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 232 KHMHIFTAPINVIFKRLPDGLGPLLPlehdgkPIDFENPPDDATFGRGKVEDF-----SWKAMLDFA-TCTECGRCQSQC 305
Cdd:COG0247    17 RFMAPFLELELGKIKYAFDPDNKLNP------GKIGLLNPGVELLGDGDLHDKnlktlPWKELLDALdACVGCGFCRAMC 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 306 PAWNT--GKPLSPKLVIMDLRDHwmakapyilgdkesslestpagglgeeLSGEEhaeahhvpesgfgrvmgsgpeqaar 383
Cdd:COG0247    91 PSYKAtgDEKDSPRGRINLLREV---------------------------LEGEL------------------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 384 PLVGTEEQggvidPDVLWSCVSCGACVEQCPVDIEHVDHIIDMRRYQVmmesefpselsvlfknlETKGNPWgqnasdRT 463
Cdd:COG0247   119 PLDLSEEV-----YEVLDLCLTCKACETACPSGVDIADLIAEARAQLV-----------------ERGGRPL------RD 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 464 NWIDEVDFDVPVYGEDvdsfdGYEYLFWVGCAGAYddKAKKTTKAVAELLAIAGVKYlVLGTGESCNGDSARRSGNEFLF 543
Cdd:COG0247   171 RLLRTFPDRVPAADKE-----GAEVLLFPGCFTNY--FDPEIGKAAVRLLEAAGVEV-VLPPEELCCGAPALSKGDLDLA 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 544 QQLAAQAVETLDGLfeGTEtvdrKIVVTCPHCFNTLGREYRQLGAN---YSVLHHTQLLNRLVRDNRLvPVTPVSQDITY 620
Cdd:COG0247   243 RKLARRNIEALERL--GVK----AIVTTCPSCGLTLKDEYPELLGDrvaFEVLDISEFLAELILEGKL-KLKPLGEKVTY 315

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 621 HDPCYLGRHNKVYEAPRELIGT-SGANLTEMPrhaERSFCCGAGGARMWMEEHIGKRINHERVDEALATGATTIATACPF 699
Cdd:COG0247   316 HDPCHLGRGGGVYDAPRELLKAiPGVEVVEMP---EDSGCCGGAGGYGFEEPELSMRIGERKLEQIRATGADVVVTACPS 392

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1180344225 700 CRVMVTDGVNDRqeeagrsGVEVLDVAQILLASLE 734
Cdd:COG0247   393 CRTQLEDGTKEY-------GIEVKHPVELLAEALG 420
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 400-730 4.61e-19

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 91.61  E-value: 4.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 400 LWSCVSCGACVEQCPVDIEHVDHIIDMRRyqvmmESEFPSELSvLFKNLETKGNPWGQNAS---DRTNWIDEVDfDVPVY 476
Cdd:PRK06259  184 LYNCTTCGKCVEVCPKEIDIPGKAIEKLR-----ALAFKKGLG-LPAHLEVRENVLKTGRSvpkEKPSFLEEVS-DIYPY 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 477 GEDvdsfdGYEYLFWVGCAgaYDDKAKKTTKAVAELLAIAGVKyLVLGTGESCNGDSARRSGNEFLFQQLAAQAVETLDG 556
Cdd:PRK06259  257 GNE-----KLRVAFFTGCL--VDYRLQEVGKDAIRVLNAHGIS-VIIPKNQVCCGSPLIRTGQTDVAEELKKKNLEIFNK 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 557 LfegtetvDRKIVVT-CPHCFNTLGREYRQlgANYSVLHHTQLLNRLvrdnRLVPVTPVSQDITYHDPCYLGRHNKVYEA 635
Cdd:PRK06259  329 L-------DVDTVVTiCAGCGSTLKNDYKE--KEFNVMDITEVLVEV----GLEKYKPLDITVTYHDPCHLRRGQGIYEE 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 636 PRELIgTSGANLT--EMPRHAErsfCCGAGG----ARMWMEEHIGKRinheRVDEALATGATTIATACPFCRVMVTDGVN 709
Cdd:PRK06259  396 PRKIL-RSIPGLEfvEMEIPDQ---CCGAGGgvrsGKPEIAEALGKR----KAEMIRETGADYVITVCPFCEYHIRDSLK 467

                         330       340
                  ....*....|....*....|.
gi 1180344225 710 drqeeAGRSGVEVLDVAQILL 730
Cdd:PRK06259  468 -----KYSEDIPVMNIVSLLD 483
CCG pfam02754
Cysteine-rich domain; The key element of this family is the CX31-38CCX33-34CXXC sequence motif ...
 618-704 1.81e-13

Cysteine-rich domain; The key element of this family is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins. There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster. The family includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase and glycerol-3-phosphate dehydrogenase.


Pssm-ID: 397052 [Multi-domain]  Cd Length: 84  Bit Score: 66.57  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 618 ITYHDPCYLGRHnkVYEAPRELIG-TSGANLTEMPRHaERSFCCGAGGARMWMEEhIGKRINHERVDEALATGATTIATA 696
Cdd:pfam02754   1 VAYFDGCHLGRA--LYPEPRKALKkVLGALGVEVVIL-EKQSCCGAGGGFSGKED-VAEALAKRNIDTAEETGADAIVTA 76


                  ....*...
gi 1180344225 697 CPFCRVMV 704
Cdd:pfam02754  77 CPGCLLQL 84
CCG pfam02754
Cysteine-rich domain; The key element of this family is the CX31-38CCX33-34CXXC sequence motif ...
 488-579 1.78e-12

Cysteine-rich domain; The key element of this family is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins. There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster. The family includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase and glycerol-3-phosphate dehydrogenase.


Pssm-ID: 397052 [Multi-domain]  Cd Length: 84  Bit Score: 63.87  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 488 YLFWVGCAgAYDDKAKKTTKAVAELLAIAGVKYLVLGtGESCNGDSARRSGNEFLFQQLAAQAVETLDglfegtETVDRK 567
Cdd:pfam02754   1 VAYFDGCH-LGRALYPEPRKALKKVLGALGVEVVILE-KQSCCGAGGGFSGKEDVAEALAKRNIDTAE------ETGADA 72

                          90
                  ....*....|..
gi 1180344225 568 IVVTCPHCFNTL 579
Cdd:pfam02754  73 IVTACPGCLLQL 84
HdrC COG1150
Heterodisulfide reductase, subunit C [Energy production and conversion];
394-431 2.26e-06

Heterodisulfide reductase, subunit C [Energy production and conversion];


Pssm-ID: 440764 [Multi-domain]  Cd Length: 79  Bit Score: 46.43  E-value: 2.26e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1180344225 394 VIDPDVLWSCVSCGACVEQCPVDIEHVDHIIDMRRYQV 431
Cdd:COG1150    40 VLKSDSIWLCVSCYTCTERCPRGIDIADVMDALRNLAI 77
glpC PRK11168
anaerobic glycerol-3-phosphate dehydrogenase subunit C;
493-675 9.07e-06

anaerobic glycerol-3-phosphate dehydrogenase subunit C;


Pssm-ID: 236869 [Multi-domain]  Cd Length: 396  Bit Score: 49.10  E-value: 9.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 493 GCAGAYDDKakKTTKAVAELLAIAGvkYLVLGTGESC-------NG--DSARRSGnEFLFQQLAAQAVETLDglfegtet 563
Cdd:PRK11168  169 GCYVNYNHP--QLGKDLVKVLNAMG--YEVLLPKEKCcglpliaNGflDKARKQA-EFNVESLREAIEKGIP-------- 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 564 vdrkIVVTCPHCFNTLGREYRQL----GANYSVLHH--TQLLNRLVRDNRLVPVTPVSQDITYHDPCYLGRHNKVYEApR 637
Cdd:PRK11168  236 ----VIATSSSCTLTLRDEYPELlgvdNAGVRDHIEdaTEFLRRLLDQGKLLPLKPLPLKVAYHTPCHLEKQGWGLYT-L 310

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1180344225 638 ELIGT-SGANLTEMPrhaerSFCCGAGGARMWMEEH------IGK 675
Cdd:PRK11168  311 ELLRLiPGLEVVVLD-----SQCCGIAGTYGFKKEKyetsqaIGA 350
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 394-428 8.76e-05

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 45.12  E-value: 8.76e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1180344225 394 VIDPDVLWSCVSCGACVEQCPVDIEHVDHIIDMRR 428
Cdd:COG0479   191 LEDEEGVWRCTTCGNCTEVCPKGIPPTKAIAKLKR 225
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 389-417 2.27e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 40.37  E-value: 2.27e-04
                          10        20
                  ....*....|....*....|....*....
gi 1180344225 389 EEQGGVIDPDVLWSCVSCGACVEQCPVDI 417
Cdd:pfam13183  36 RLEALEGLAEGLWLCTLCGACTEVCPVGI 64
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 394-417 8.74e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 37.61  E-value: 8.74e-04
                          10        20
                  ....*....|....*....|....
gi 1180344225 394 VIDPDvlwSCVSCGACVEQCPVDI 417
Cdd:pfam00037   2 VIDEE---KCIGCGACVEVCPVGA 22
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 394-421 8.75e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 38.87  E-value: 8.75e-04
                          10        20
                  ....*....|....*....|....*....
gi 1180344225 394 VIDPDvlwSCVSCGACVEQCPVD-IEHVD 421
Cdd:COG4231    47 VIDPD---LCIGCGSCVQVCPVDaIKLEK 72
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 290-414 1.02e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 38.00  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180344225 290 LDFATCTECGRCQSQCPAWNTGkplspklvimdlrdhwmakapyilgdkesslestpaGGLGEELSGEEHAEahhvpesg 369
Cdd:pfam13237   4 IDPDKCIGCGRCTAACPAGLTR------------------------------------VGAIVERLEGEAVR-------- 39

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1180344225 370 fgrvmgsgpeqaarplvgteeqggvidpDVLWSCVSCGACVEQCP 414
Cdd:pfam13237  40 ----------------------------IGVWKCIGCGACVEACP 56
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 394-425 1.35e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 39.69  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1180344225 394 VIDPDVlwsCVSCGACVEQCPVD-IEHVD---HIID 425
Cdd:cd10549    74 EIDEEK---CIGCGLCVKVCPVDaITLEDeleIVID 106
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 394-425 1.86e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 38.10  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1180344225 394 VIDPDVlwsCVSCGACVEQCPVD-IEHVD--HIID 425
Cdd:COG4231    18 VIDEDK---CTGCGACVKVCPADaIEEGDgkAVID 49
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 394-427 1.88e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 41.13  E-value: 1.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1180344225 394 VIDPDVlwsCVSCGACVEQCPVDiehvdhIIDMR 427
Cdd:COG2878   163 TVDEDK---CTGCGLCVEACPVD------CIEMV 187
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 394-424 1.89e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 37.80  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1180344225 394 VIDPDVlwsCVSCGACVEQCPVD-IEHVDHII 424
Cdd:COG1143    31 VIDPDK---CIGCGLCVEVCPTGaISMTPFEL 59
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 386-417 2.15e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 39.30  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1180344225 386 VGTEEQGGVIDPDvlwSCVSCGACVEQCPVDI 417
Cdd:cd10549    28 NGAIARGPEIDED---KCVFCGACVEVCPTGA 56
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 394-417 3.15e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 37.00  E-value: 3.15e-03
                          10        20
                  ....*....|....*....|....
gi 1180344225 394 VIDPDvlwSCVSCGACVEQCPVDI 417
Cdd:COG1146     4 VIDTD---KCIGCGACVEVCPVDV 24
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 378-428 3.97e-03

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 37.34  E-value: 3.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1180344225 378 PEQAARPlvgTEEQGGVIDPDvlwSCVSCGACVEQCPVdiehvdHIIDMRR 428
Cdd:COG1144    43 PDGAIRV---DDGKYYGIDYD---YCKGCGICAEVCPV------KAIEMVP 81
Fer4_2 pfam12797
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 286-307 5.99e-03

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 463711 [Multi-domain]  Cd Length: 22  Bit Score: 35.07  E-value: 5.99e-03
                          10        20
                  ....*....|....*....|..
gi 1180344225 286 WKAMLDFATCTECGRCQSQCPA 307
Cdd:pfam12797   1 WKPLIDADKCIGCGACVSACPA 22
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
394-429 6.04e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 36.63  E-value: 6.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1180344225 394 VIDPDVlwsCVSCGACVEQCPVD---IEHVDHIIDMRRY 429
Cdd:COG2768    36 VIDPEK---CIGCGACIEVCPVGaikIEWEEDEEFQEKM 71
Fer4_9 pfam13187
4Fe-4S dicluster domain;
295-325 6.09e-03

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 35.61  E-value: 6.09e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1180344225 295 CTECGRCQSQCPAWNTGKPLSPKLVIMDLRD 325
Cdd:pfam13187   2 CTGCGACVAACPAGAIVPDLVGQTIRGDIAG 32
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 394-421 8.69e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.84  E-value: 8.69e-03
                          10        20
                  ....*....|....*....|....*....
gi 1180344225 394 VIDPDvlwSCVSCGACVEQCPVD-IEHVD 421
Cdd:COG1146    36 VINPE---ECIGCGACELVCPVGaITVED 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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