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Conserved domains on  [gi|1181172003|ref|WP_084519514|]
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MULTISPECIES: iron ABC transporter permease [Corynebacterium]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 8-312 1.69e-72

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 226.11  E-value: 1.69e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   8 SLFIGAQSFSPSEIVAGLRGGPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNAGAAFAA 87
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  88 ALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdVSGAIDPLRIVLAGVALSAVFEGLSEGMSLL-DPQAFARIKAWM 166
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 167 VGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGVLAFVGM 246
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1181172003 247 LVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLIL-PGELPAGVTVAIIGAPFLIFLAQRKQ 312
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILaPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 8-312 1.69e-72

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 226.11  E-value: 1.69e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   8 SLFIGAQSFSPSEIVAGLRGGPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNAGAAFAA 87
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  88 ALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdVSGAIDPLRIVLAGVALSAVFEGLSEGMSLL-DPQAFARIKAWM 166
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 167 VGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGVLAFVGM 246
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1181172003 247 LVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLIL-PGELPAGVTVAIIGAPFLIFLAQRKQ 312
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILaPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 1-310 3.14e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 202.37  E-value: 3.14e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFSPSEIVAGLRGgPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLG-GDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdVSGAIDPLRIVLAGVALSAVFEGLSEGM-SLLDPQAF 159
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLlLLLNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 160 ARIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVG 239
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1181172003 240 VLAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLIL-PGELPAGVTVAIIGAPFLIFLAQR 310
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILsPYELPVGIVTALIGAPFFIYLLLR 311
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
1-312 1.94e-62

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 201.09  E-value: 1.94e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFSPSEIVAGLRGGPGSSTAgDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:PRK10441   20 LIIATALSLLIGAKSLPASVVLEALSGTCQSADC-TIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVN 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRDVSGAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFA 160
Cdd:PRK10441   99 AGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 161 RIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGV 240
Cdd:PRK10441  179 QLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGP 258

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1181172003 241 LAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLILPGELPAGVTVAIIGAPFLIFLAQRKQ 312
Cdd:PRK10441  259 IAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLVPGELRVSVVSAFIGAPVLIFLVRRKT 330
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 46-307 6.68e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 140.38  E-value: 6.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  46 TVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNAGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdvS 125
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLAS--R 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 126 GAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFARIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLG 205
Cdd:cd06550    79 GGLSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 206 EHAAEALGINVAQTRALALFVVSLLAATTTAAVGVLAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLI 285
Cdd:cd06550   159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                         250       260
                  ....*....|....*....|..
gi 1181172003 286 LPGELPAGVTVAIIGAPFLIFL 307
Cdd:cd06550   239 LPSELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 8-312 1.69e-72

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 226.11  E-value: 1.69e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   8 SLFIGAQSFSPSEIVAGLRGGPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNAGAAFAA 87
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  88 ALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdVSGAIDPLRIVLAGVALSAVFEGLSEGMSLL-DPQAFARIKAWM 166
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 167 VGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGVLAFVGM 246
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1181172003 247 LVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLIL-PGELPAGVTVAIIGAPFLIFLAQRKQ 312
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILaPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 1-310 3.14e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 202.37  E-value: 3.14e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFSPSEIVAGLRGgPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLG-GDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdVSGAIDPLRIVLAGVALSAVFEGLSEGM-SLLDPQAF 159
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLlLLLNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 160 ARIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVG 239
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1181172003 240 VLAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLIL-PGELPAGVTVAIIGAPFLIFLAQR 310
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILsPYELPVGIVTALIGAPFFIYLLLR 311
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
1-312 1.94e-62

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 201.09  E-value: 1.94e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFSPSEIVAGLRGGPGSSTAgDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:PRK10441   20 LIIATALSLLIGAKSLPASVVLEALSGTCQSADC-TIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVN 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRDVSGAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFA 160
Cdd:PRK10441   99 AGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 161 RIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGV 240
Cdd:PRK10441  179 QLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGP 258

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1181172003 241 LAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLILPGELPAGVTVAIIGAPFLIFLAQRKQ 312
Cdd:PRK10441  259 IAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLVPGELRVSVVSAFIGAPVLIFLVRRKT 330
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-307 3.05e-47

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 168.09  E-value: 3.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFspseivaGLRGGPGSstAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:PRK10577  365 LLLALVVALSFGRDAH-------GWNWLSGQ--LLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGIS 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdvSGAIDPLRIVLAGVALSAVFEGL-SEGMSLLDPQAf 159
Cdd:PRK10577  436 SGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLAR--RGGFAPERLLLTGIALSALFTALiQLLLASGDPRA- 512

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 160 ARIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVG 239
Cdd:PRK10577  513 AQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVG 592

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1181172003 240 VLAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLIL-PGELPAGVTVAIIGAPFLIFL 307
Cdd:PRK10577  593 PLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLfPYQIPAGLLAALIGAPYFLWL 661
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 2-307 2.20e-43

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 151.81  E-value: 2.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   2 VLLIVLSLFIGAQSFSPSEIVAGLRGGpGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNA 81
Cdd:COG4779    34 LALAVLALTLGDYPLSPGDVLRALLGE-GDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  82 GAAFAAALALSVFGlSSPIAFTAAALIGASGTMLLVARLGRdvSGAIDPLRIVLAGVALSAVFEGL-SEGMSLLDPQAFA 160
Cdd:COG4779   113 GASAGAVAAIVVLG-GSGLAVALGALAGGLATALLVYLLAW--RGGVSGYRLILVGIGVSAMLTAVnSYLLTRADLEDAQ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 161 RIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGV 240
Cdd:COG4779   190 SAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGP 269

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1181172003 241 LAFVGMLVPHLVRQVGITNeRDQIWISGLIGPNLLLFADIIGR-LILPGELPAGVTVAIIGAPFLIFL 307
Cdd:COG4779   270 IAFVALAAPQIARRLTRSP-GPPLLPSALVGALLLLAADLVAQhLLAPVQLPVGVVTGALGGPYLLWL 336
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
2-310 4.50e-42

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 153.84  E-value: 4.50e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   2 VLLIVLSLFIGAQSFSPSEIVAGLRGGPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNA 81
Cdd:PRK10577   22 LLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  82 GAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdvSGAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFAR 161
Cdd:PRK10577  102 GAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAG--GKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQG 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 162 IKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGVL 241
Cdd:PRK10577  180 LFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPI 259

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1181172003 242 AFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLI---LPGELPAGVTVAIIGAPFLIFLAQR 310
Cdd:PRK10577  260 GFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagvGGELLPTGAVTALIGAPLLLWLLPR 331
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 46-307 6.68e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 140.38  E-value: 6.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  46 TVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNAGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVARLGRdvS 125
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLAS--R 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 126 GAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFARIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLG 205
Cdd:cd06550    79 GGLSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 206 EHAAEALGINVAQTRALALFVVSLLAATTTAAVGVLAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLI 285
Cdd:cd06550   159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                         250       260
                  ....*....|....*....|..
gi 1181172003 286 LPGELPAGVTVAIIGAPFLIFL 307
Cdd:cd06550   239 LPSELPVGPVTALLGAPYFLYL 260
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
7-311 4.93e-39

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 139.83  E-value: 4.93e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   7 LSLFI-GAQSFSPSEIVAGLRGGPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNAGAAF 85
Cdd:PRK11228   15 LSLFCySAIPISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAAL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  86 AAALALSVfgLSSPIAFTAAALIGASG---TMLLVARLGRDVSGAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFARI 162
Cdd:PRK11228   95 AMALTSAL--SPTPFAGYSLAFIAACGgglSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGI 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 163 KAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGVLA 242
Cdd:PRK11228  173 FYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVA 252

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 243 FVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGR-LILPGELPAGVTVAIIGAPFLIFLAQRK 311
Cdd:PRK11228  253 FIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARaLAFPGELPAGAVLALIGAPCFVWLARRR 322
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 1-312 1.00e-38

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 139.22  E-value: 1.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFSPSEIVaglrggpgSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:COG4139    22 LLLLFVLSLCAGEVWIPPTQWL--------SEAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGIS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGLSSPI-AFTAAALIGASGTMLLVARLGRDVsgaIDPLRIVLAGVALSAVFEGLsegMSLL----D 155
Cdd:COG4139    94 NGAGVGLVLVVLLGGGLLPPwLLSLAAIAGALLVTLLLLAFARRR---LSNARLLLIGVALGIICSAI---MTWAvyfsS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 156 PQAFARIKAWMVGSMDIAATTPLYLMGCgLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTT 235
Cdd:COG4139   168 SLDLRQLMYWMMGSFGGVDWRQLWLLLA-LLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSV 246

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1181172003 236 AAVGVLAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLILP-GELPAGVTVAIIGAPFLIFLAQRKQ 312
Cdd:COG4139   247 ALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSsAELPIGVVTATLGAPVFIWLLLRRR 324
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 1-314 3.69e-34

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 127.38  E-value: 3.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFSPSEivaglrggPGSSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:PRK03784   25 LLLALLLSLCAGEQWISPGD--------WLSPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVF-GLSSPIAFTAAALIGASGTMLLVARLGRdvSGAIDPLRIVLAGVALSAVFEGL-SEGMSLLDPQA 158
Cdd:PRK03784   97 NGAGVALVAAVLLGqGLLPPWALSLCAIAGALLITLILLRFAR--RHRLSTSRLLLAGVALGIICSALmTWAVYFSTSLD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 159 FARIKAWMVGSMDIAATTPLYLMGCgLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAV 238
Cdd:PRK03784  175 LRQLMYWMMGGFGGVDWRQSWLMLA-LLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALA 253

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1181172003 239 GVLAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLILP-GELPAGVTVAIIGAPFLIFLAQRKQVV 314
Cdd:PRK03784  254 GAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALAsAELPIGVVTATLGAPVFIWLLLRSHRA 330
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
1-310 4.71e-34

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 126.70  E-value: 4.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   1 MVLLIVLSLFIGAQSFSPSEIVAGLRGGPGSSTAgdiLYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:PRK09777   13 LAGCALLSLRMGVIPLPWRALLTDWQAGDEHYYV---LMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGLSSPIAFTAAALIGASGTMLLVarlgRDVSGAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFA 160
Cdd:PRK09777   90 HAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILL----KMLAGTHQPMKLALTGVALSALWASLTDYLMLSRPQDIN 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 161 RIKAWMVGSMDIAATTPLYLMGCGLAIAAVMLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGV 240
Cdd:PRK09777  166 NALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGP 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1181172003 241 LAFVGMLVPHLVRQVGITNERDQIWISGLIGPNLLLFADIIGRLILPG-ELPAGVTVAIIGAPFLIFLAQR 310
Cdd:PRK09777  246 ISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPlELPAGVLTAIIGAPWFFWLLVR 316
btuC PRK09535
cobalamin ABC transporter permease BtuC;
31-313 3.26e-25

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 103.68  E-value: 3.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  31 SSTAGDILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMNAGAAFAAALALsVFGLSSPIAFTAAALIGA 110
Cdd:PRK09535   84 PETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAI-VLPLAVPFGLQAAAFAGA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 111 SGTMLLVARLGRDvSGAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFARIKAWMVGSMDIAATTPLYLMGCGLAIAAV 190
Cdd:PRK09535  163 LVAAFGVYAIATE-NGRTPVATLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFV 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 191 MLLFLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAAVGVLAFVGMLVPHLVRQVGITNERDQIWISGLI 270
Cdd:PRK09535  242 VLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALA 321

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1181172003 271 GPNLLLFADIIGRLIlPGELPAGVTVAIIGAPFLIFLAQRKQV 313
Cdd:PRK09535  322 GASFLVATDTVARSG-PAEVPVGIVTAALGAPFFLYLLRTREV 363
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
2-307 1.32e-22

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 95.93  E-value: 1.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003   2 VLLIVLSLFIGAQSFSPSEIVAGLRG-GPGSSTAgdILYERRIPRTVAAILAGTGLAVAGCILQIITRNPLADTGVFGMN 80
Cdd:PRK10440   20 VAAGLWGLRSGAVTLETSQVFAALMGdAPRSMTM--VVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFN 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003  81 AGAAFAAALALSVFGlSSPIAFTAAALIGASGTMLLVARLGRdvSGAIDPLRIVLAGVALSAVFEGLSEGMSLLDPQAFA 160
Cdd:PRK10440   98 TGAWSGVLVAMVLFG-QDLTAIALAAMAGGIVTSLLVWLLAW--RNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181172003 161 RIKA-WMVGSMD--IAATTPLYLMGCGLAIAAVMLlfLAPRLTVLPLGEHAAEALGINVAQTRALALFVVSLLAATTTAA 237
Cdd:PRK10440  175 LTAGlWNAGSLNglTWAKTSPSAPIIILMLIAAAL--LVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATAL 252

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1181172003 238 VGVLAFVGMLVPHLVRQVGITNeRDQIWISGLIGPNLLLFADIIG-RLILPGELPAGVTVAIIGAPFLIFL 307
Cdd:PRK10440  253 AGPISFIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAqQLFMPYQLPVGVVTVSLGGIYLIVL 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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