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Conserved domains on  [gi|1181370077|ref|WP_084669894|]
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bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG [Duganella zoogloeoides]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 62-172 8.13e-24

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 93.54  E-value: 8.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  62 RDILSVVLKHVKPGaRRLLDVGCAHGWFLET-ARAHFDVLGVEPDS----VVGSRTASRGLPVRPGYFPDALTPDESFDV 136
Cdd:COG2227    12 RRLAALLARLLPAG-GRVLDVGCGTGRLALAlARRGADVTGVDISPealeIARERAAELNVDFVQGDLEDLPLEDGSFDL 90

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1181370077 137 IVFNDVIEHIPDIASALEACNARLSENGLLVLNLPN 172
Cdd:COG2227    91 VICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 62-172 8.13e-24

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 93.54  E-value: 8.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  62 RDILSVVLKHVKPGaRRLLDVGCAHGWFLET-ARAHFDVLGVEPDS----VVGSRTASRGLPVRPGYFPDALTPDESFDV 136
Cdd:COG2227    12 RRLAALLARLLPAG-GRVLDVGCGTGRLALAlARRGADVTGVDISPealeIARERAAELNVDFVQGDLEDLPLEDGSFDL 90

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1181370077 137 IVFNDVIEHIPDIASALEACNARLSENGLLVLNLPN 172
Cdd:COG2227    91 VICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-223 4.41e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 92.88  E-value: 4.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  57 RQENFRDILSVVLKHVKPGARrLLDVGCAHGWFLETARAH-FDVLGVEPdSVVGSRTASRGLPVRPGYFPDALTPDESFD 135
Cdd:pfam13489   5 RERLLADLLLRLLPKLPSPGR-VLDFGCGTGIFLRLLRAQgFSVTGVDP-SPIAIERALLNVRFDQFDEQEAAVPAGKFD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077 136 VIVFNDVIEHIPDIASALEACNARLSENGLLVLNLPNsrgffyrlskifARLGWRNPFNRLWQKDLPSPHVHYFNPRNLE 215
Cdd:pfam13489  83 VIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPL------------ASDEADRLLLEWPYLRPRNGHISLFSARSLK 150


                  ....*...
gi 1181370077 216 LLVTRHGF 223
Cdd:pfam13489 151 RLLEEAGF 158
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 78-168 8.17e-07

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 48.83  E-value: 8.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  78 RLLDVGCAHGWFLET-ARAHFDVLGVEP-DSVVGSRTASRGL-PVRPGYFPDAL-----TPDESFDVIVFNDVIEHIPDI 149
Cdd:TIGR01983  49 RVLDVGCGGGLLSEPlARLGANVTGIDAsEENIEVAKLHAKKdPLQIDYRCTTVedlaeKKAGSFDVVTCMEVLEHVPDP 128

                          90
                  ....*....|....*....
gi 1181370077 150 ASALEACNARLSENGLLVL 168
Cdd:TIGR01983 129 QAFIRACAQLLKPGGILFF 147
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 78-168 1.35e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.27  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  78 RLLDVGCAHGWFLETARAHFD--VLGVEPDSVV---GSRTASRGLPVRPGYFP-DALT----PDESFDVIVFNDVIEHI- 146
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGarVTGVDISPVAlelARKAAAALLADNVEVLKgDAEElppeADESFDVIISDPPLHHLv 80

                          90       100
                  ....*....|....*....|..
gi 1181370077 147 PDIASALEACNARLSENGLLVL 168
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVL 102
PRK08317 PRK08317
hypothetical protein; Provisional
 54-226 1.43e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.15  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  54 KSLRQENFRDIlsvvlkHVKPGARrLLDVGCAHGWFL-ETARAhfdvlgVEPDS-VVG------------SRTASRGLPV 119
Cdd:PRK08317    5 RRYRARTFELL------AVQPGDR-VLDVGCGPGNDArELARR------VGPEGrVVGidrseamlalakERAAGLGPNV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077 120 RpGYFPDALT---PDESFDVIVFNDVIEHIPDIASAL-EAcnAR-LSENGLLVLNLPNSRGFFY------RLSKIFarlg 188
Cdd:PRK08317   72 E-FVRGDADGlpfPDGSFDAVRSDRVLQHLEDPARALaEI--ARvLRPGGRVVVLDTDWDTLVWhsgdraLMRKIL---- 144

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1181370077 189 wrnpfnRLWQKDLPSPHVhyfnPRNLELLVTRHGFVSV 226
Cdd:PRK08317  145 ------NFWSDHFADPWL----GRRLPGLFREAGLTDI 172
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 62-172 8.13e-24

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 93.54  E-value: 8.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  62 RDILSVVLKHVKPGaRRLLDVGCAHGWFLET-ARAHFDVLGVEPDS----VVGSRTASRGLPVRPGYFPDALTPDESFDV 136
Cdd:COG2227    12 RRLAALLARLLPAG-GRVLDVGCGTGRLALAlARRGADVTGVDISPealeIARERAAELNVDFVQGDLEDLPLEDGSFDL 90

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1181370077 137 IVFNDVIEHIPDIASALEACNARLSENGLLVLNLPN 172
Cdd:COG2227    91 VICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-223 4.41e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 92.88  E-value: 4.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  57 RQENFRDILSVVLKHVKPGARrLLDVGCAHGWFLETARAH-FDVLGVEPdSVVGSRTASRGLPVRPGYFPDALTPDESFD 135
Cdd:pfam13489   5 RERLLADLLLRLLPKLPSPGR-VLDFGCGTGIFLRLLRAQgFSVTGVDP-SPIAIERALLNVRFDQFDEQEAAVPAGKFD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077 136 VIVFNDVIEHIPDIASALEACNARLSENGLLVLNLPNsrgffyrlskifARLGWRNPFNRLWQKDLPSPHVHYFNPRNLE 215
Cdd:pfam13489  83 VIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPL------------ASDEADRLLLEWPYLRPRNGHISLFSARSLK 150


                  ....*...
gi 1181370077 216 LLVTRHGF 223
Cdd:pfam13489 151 RLLEEAGF 158
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 72-190 6.51e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.93  E-value: 6.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  72 VKPGARrLLDVGCAHGWFLET-ARAHFDVLGVEPDS----VVGSRTASRGLPVRP--GYFPDALTPDESFDVIVFNDVIE 144
Cdd:COG2226    20 LRPGAR-VLDLGCGTGRLALAlAERGARVTGVDISPemleLARERAAEAGLNVEFvvGDAEDLPFPDGSFDLVISSFVLH 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1181370077 145 HIPDIASALEACNARLSENGLLVL---NLPNSRgffyRLSKIFARLGWR 190
Cdd:COG2226    99 HLPDPERALAEIARVLKPGGRLVVvdfSPPDLA----ELEELLAEAGFE 143
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
67-179 1.60e-11

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 61.94  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  67 VVLKHVKPGARRLLDVGCAHGWFLETARAHF-DVLGVEPDSVVGSRTASRGLPVR--PGYFPDALTPDESFDVIVFNDVI 143
Cdd:COG4976    38 LLARLPPGPFGRVLDLGCGTGLLGEALRPRGyRLTGVDLSEEMLAKAREKGVYDRllVADLADLAEPDGRFDLIVAADVL 117

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1181370077 144 EHIPDIASALEACNARLSENGLLVLNLP--NSRGFFYR 179
Cdd:COG4976   118 TYLGDLAAVFAGVARALKPGGLFIFSVEdaDGSGRYAH 155
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
75-168 1.64e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 59.84  E-value: 1.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  75 GARRLLDVGCAHGWFLETARAHF---DVLGVE--PDSVVGSRTASRGLPVRPGyfpDA--LTPDESFDVIVFNDVIEHIP 147
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFpgaRVTGVDlsPEMLARARARLPNVRFVVA---DLrdLDPPEPFDLVVSNAALHWLP 77

                          90       100
                  ....*....|....*....|.
gi 1181370077 148 DIASALEACNARLSENGLLVL 168
Cdd:COG4106    78 DHAALLARLAAALAPGGVLAV 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 72-168 2.11e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 58.02  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  72 VKPGARrLLDVGCAHGWFLETA--RAHFDVLGVEPDSV----VGSRTASRGLPVRPGYFP-DA--LTPDESFDVIVFNDV 142
Cdd:COG2230    49 LKPGMR-VLDIGCGWGGLALYLarRYGVRVTGVTLSPEqleyARERAAEAGLADRVEVRLaDYrdLPADGQFDAIVSIGM 127

                          90       100
                  ....*....|....*....|....*...
gi 1181370077 143 IEHIPD--IASALEACNARLSENGLLVL 168
Cdd:COG2230   128 FEHVGPenYPAYFAKVARLLKPGGRLLL 155
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 80-166 9.82e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 54.68  E-value: 9.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  80 LDVGCAHGWFLETARAHF---DVLGVEPDSV--------VGSRTASRGLPVRPGYFPDALTPDESFDVIVFNDVIEHIPD 148
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALpglEYTGLDISPAaleaarerLAALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 1181370077 149 IASALEACNARLSENGLL 166
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 80-168 3.72e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 53.05  E-value: 3.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  80 LDVGCAHGWFLET-ARAHFDVLGVEPD----SVVGSRTASRGLPVRPGyfpDALT---PDESFDVIVFNDVIEHIPDIAS 151
Cdd:pfam08241   1 LDVGCGTGLLTELlARLGARVTGVDISpemlELAREKAPREGLTFVVG---DAEDlpfPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*..
gi 1181370077 152 ALEACNARLSENGLLVL 168
Cdd:pfam08241  78 ALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 74-168 2.54e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.00  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  74 PGARRLLDVGCAHGWFLE--TARAHFDVLGVEPDSVV----GSRTASRGLP-----VRPGYFPDALtPDESFDVIVFNDV 142
Cdd:COG0500    25 PKGGRVLDLGCGTGRNLLalAARFGGRVIGIDLSPEAialaRARAAKAGLGnveflVADLAELDPL-PAESFDLVVAFGV 103

                          90       100
                  ....*....|....*....|....*...
gi 1181370077 143 IEHIP--DIASALEACNARLSENGLLVL 168
Cdd:COG0500   104 LHHLPpeEREALLRELARALKPGGVLLL 131
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 80-164 1.14e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 48.71  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  80 LDVGCAHGWFLETARAHF--DVLGVEPDS----VVGSRTASRGLPVRP--GYFPDALTPDESFDVIVFNDVIEHI--PDI 149
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGgaRVTGVDLSPemleRARERAAEAGLNVEFvqGDAEDLPFPDGSFDLVVSSGVLHHLpdPDL 81

                          90
                  ....*....|....*
gi 1181370077 150 ASALEACNARLSENG 164
Cdd:pfam13649  82 EAALREIARVLKPGG 96
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 78-168 8.17e-07

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 48.83  E-value: 8.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  78 RLLDVGCAHGWFLET-ARAHFDVLGVEP-DSVVGSRTASRGL-PVRPGYFPDAL-----TPDESFDVIVFNDVIEHIPDI 149
Cdd:TIGR01983  49 RVLDVGCGGGLLSEPlARLGANVTGIDAsEENIEVAKLHAKKdPLQIDYRCTTVedlaeKKAGSFDVVTCMEVLEHVPDP 128

                          90
                  ....*....|....*....
gi 1181370077 150 ASALEACNARLSENGLLVL 168
Cdd:TIGR01983 129 QAFIRACAQLLKPGGILFF 147
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 78-168 1.35e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.27  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  78 RLLDVGCAHGWFLETARAHFD--VLGVEPDSVV---GSRTASRGLPVRPGYFP-DALT----PDESFDVIVFNDVIEHI- 146
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGarVTGVDISPVAlelARKAAAALLADNVEVLKgDAEElppeADESFDVIISDPPLHHLv 80

                          90       100
                  ....*....|....*....|..
gi 1181370077 147 PDIASALEACNARLSENGLLVL 168
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVL 102
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 78-202 2.16e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.86  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  78 RLLDVGCAHGWFL----ETARAHFDVLGVE--PDSVVGSRTASRGLPV-----RPGYFPDALT--PDESFDVIVFNDVIE 144
Cdd:pfam13847   6 RVLDLGCGTGHLSfelaEELGPNAEVVGIDisEEAIEKARENAQKLGFdnvefEQGDIEELPEllEDDKFDVVISNCVLN 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1181370077 145 HIPDIASAL-EACNArLSENGLLVLNLPNSRGFFYRLSKIFARLGWRNPFNRLWQKDLP 202
Cdd:pfam13847  86 HIPDPDKVLqEILRV-LKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKKLY 143
MetW pfam07021
Methionine biosynthesis protein MetW; This family consists of several bacterial and one ...
 62-146 2.42e-04

Methionine biosynthesis protein MetW; This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalyzed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganizms the reaction is catalyzed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells.


Pssm-ID: 399779  Cd Length: 193  Bit Score: 41.29  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  62 RDILSVVLKHVKPGARrLLDVGCAHGWFLETARAHFDVL--GVEPDSVVGSRTASRGLPVRPGYFPDALT--PDESFDVI 137
Cdd:pfam07021   1 RADFRYILEWIPPGSR-VLDLGCGDGTLLYLLKEEKGVDgyGIELDAAGVAECVAKGLYVIQGDLDEGLEhfPDKSFDYV 79


                  ....*....
gi 1181370077 138 VFNDVIEHI 146
Cdd:pfam07021  80 ILSQTLQAT 88
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
78-226 5.50e-04

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 39.85  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  78 RLLDVGCAH----GWFletaraHFD-VLGVEPDSVVgsrTASRGLPVrpgyfpdaltPDESFDVIVFNDVIEHIP--DIA 150
Cdd:COG4627     5 LKLNIGCGPkrlpGWL------NVDiVPAPGVDIVG---DLTDPLPF----------PDNSVDAIYSSHVLEHLDyeEAP 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077 151 SALEACNARLSENGLLVLNLPN---------SRGFFYRLSKIFARLGWRNPFNRLWQKDLP---SPHVHYFNPRNLELLV 218
Cdd:COG4627    66 LALKECYRVLKPGGILRIVVPDlehvarlylAEYDAALDVAELRLAGPIDPLGIILGERLAglaARHSVLFRTGFTRLAL 145


                  ....*...
gi 1181370077 219 TRHGFVSV 226
Cdd:COG4627   146 TARRSAAG 153
PRK08317 PRK08317
hypothetical protein; Provisional
 54-226 1.43e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.15  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077  54 KSLRQENFRDIlsvvlkHVKPGARrLLDVGCAHGWFL-ETARAhfdvlgVEPDS-VVG------------SRTASRGLPV 119
Cdd:PRK08317    5 RRYRARTFELL------AVQPGDR-VLDVGCGPGNDArELARR------VGPEGrVVGidrseamlalakERAAGLGPNV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181370077 120 RpGYFPDALT---PDESFDVIVFNDVIEHIPDIASAL-EAcnAR-LSENGLLVLNLPNSRGFFY------RLSKIFarlg 188
Cdd:PRK08317   72 E-FVRGDADGlpfPDGSFDAVRSDRVLQHLEDPARALaEI--ARvLRPGGRVVVLDTDWDTLVWhsgdraLMRKIL---- 144

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1181370077 189 wrnpfnRLWQKDLPSPHVhyfnPRNLELLVTRHGFVSV 226
Cdd:PRK08317  145 ------NFWSDHFADPWL----GRRLPGLFREAGLTDI 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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