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Conserved domains on  [gi|1188401072|ref|WP_085522072|]
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MULTISPECIES: MFS transporter [Klebsiella]

Protein Classification

MFS transporter( domain architecture ID 13022776)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
20-423 1.67e-46

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 164.31  E-value: 1.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  20 TVRSGGGSFVDGYVLSIIGIAMMKVSPA--LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCS 97
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  98 VAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPD-AWRL 176
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwGWRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 177 TLASTAVIGALLFLVRmgtpesprwliskgrhaeaeaiirkvygpdfglgnlpeqaesknlsffnllhsgygKRMAFVAI 256
Cdd:cd17316   161 LFLIGALPALLALLLR--------------------------------------------------------RRTLLLIL 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 257 FWTCSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLR 335
Cdd:cd17316   185 LWFFISFGYYGLTTFLPTYLqTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 336 DGPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASL-QSLGIGTTMYIAAAI 414
Cdd:cd17316   265 SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLaSTGGTGVPALILALL 344

                  ....*....
gi 1188401072 415 TFVGLVVSW 423
Cdd:cd17316   345 AIVALIVAL 353
 
Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
20-423 1.67e-46

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 164.31  E-value: 1.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  20 TVRSGGGSFVDGYVLSIIGIAMMKVSPA--LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCS 97
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  98 VAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPD-AWRL 176
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwGWRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 177 TLASTAVIGALLFLVRmgtpesprwliskgrhaeaeaiirkvygpdfglgnlpeqaesknlsffnllhsgygKRMAFVAI 256
Cdd:cd17316   161 LFLIGALPALLALLLR--------------------------------------------------------RRTLLLIL 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 257 FWTCSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLR 335
Cdd:cd17316   185 LWFFISFGYYGLTTFLPTYLqTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 336 DGPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASL-QSLGIGTTMYIAAAI 414
Cdd:cd17316   265 SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLaSTGGTGVPALILALL 344

                  ....*....
gi 1188401072 415 TFVGLVVSW 423
Cdd:cd17316   345 AIVALIVAL 353
Sugar_tr pfam00083
Sugar (and other) transporter;
26-434 6.28e-37

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 140.87  E-value: 6.28e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  26 GSFVDGYVLSIIG--IAMMKV---------SPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFV 94
Cdd:pfam00083   8 GGFLFGYDTGVIGafLTLIDFfknfglsksVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  95 VCSVAQYWVQSG---EMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGP 171
Cdd:pfam00083  88 IGAVLQGAAKGKwsvYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 172 DAWRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQAESKNLS------FFNLLHS 245
Cdd:pfam00083 168 DGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGqeaekaSWKELFS 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 246 GYGKRMAF---VAIFWTCSVIPVFAVYAFAPKVLDALHLSGkwGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQS-- 320
Cdd:pfam00083 248 TKTRRQRLligVMLQIFQQLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGaa 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 321 -------FLWSGLALLLLGLLRDGPSMI--ILLMFGAYALFIGGaqvLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVG 391
Cdd:pfam00083 326 gmaicfvILGIVALLGVSKSDWAGIVAIvfIALFIAFFAMGWGP---VPWVIVSELFPLSVRSKAMALATAANWLANFLI 402
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1188401072 392 TWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLAPETNARSL 434
Cdd:pfam00083 403 GFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTL 445
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
11-429 2.32e-29

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 118.05  E-value: 2.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  11 PLNRFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGP 90
Cdd:COG2271     3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  91 TLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGG 170
Cdd:COG2271    83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 171 pdaWRLTLASTAVIGALLFLVRMgtpesprWLIskgrhaeaeaiirkvygpdfglgnlpeqaesknlsffnllhsgygkr 250
Cdd:COG2271   163 ---WRAAFLILGLPGLLLALLRF-------WLL----------------------------------------------- 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 251 mafvAIFWTCSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALL 329
Cdd:COG2271   186 ----ALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 330 LLGLLRDGPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMY 409
Cdd:COG2271   262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
                         410       420
                  ....*....|....*....|
gi 1188401072 410 IAAAITFVGLVVSWWLAPET 429
Cdd:COG2271   342 LLAALALLAALLALLLLRET 361
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
7-395 5.88e-28

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 114.76  E-value: 5.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072   7 VEDVPLNRFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLY 86
Cdd:TIGR00895   6 IRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  87 FVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALL 166
Cdd:TIGR00895  86 LWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 167 -HFGgpdaWRLTLASTAVIGALLFLVRMGT-PESPRWLISKGRHAEAEAI----IRKVYGPDFGLGNLPEQAESKNLSFF 240
Cdd:TIGR00895 166 pVFG----WRSLFYVGGIAPLLLLLLLMRFlPESIDFLVSKRPETVRRIVnaiaPQMQAEAQSALPEQKSTQGTKRSVFK 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 241 NLLHSGYGKRMAFVAIFWTCSVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQS 320
Cdd:TIGR00895 242 ALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLL 321
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1188401072 321 FLWSGLALLLLGLLRDGPSMIILLMFgaYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLV 395
Cdd:TIGR00895 322 LLGAVFAVLVGSTLFSPTLLLLLGAI--AGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILA 394
xylE PRK10077
D-xylose transporter XylE; Provisional
48-448 7.10e-15

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 76.66  E-value: 7.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  48 LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYW-------VQSGEMLFALRF-----L 115
Cdd:PRK10077   50 ESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWpefgftsIGPDNTGYVPEFviyriI 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 116 NGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLhfGGPDA-------WRLTLASTAVIGALL 188
Cdd:PRK10077  130 GGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIA--RSGDAswlntdgWRYMFASEAIPALLF 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 189 FLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPDFG---LGNLPEQAESKNLSFFNLLhsGYGKRMAFVAIFwtCSVIPV 265
Cdd:PRK10077  208 LMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLAtqaLQEIKHSLDHGRKTGGKLL--MFGVGVIVIGVM--LSVFQQ 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 266 F----AVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSG--LALLLLGLLRDGPS 339
Cdd:PRK10077  284 FvginVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAigMFSLGTAFYTQAPG 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 340 MIILLMFGAY-ALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTT----------- 407
Cdd:PRK10077  364 IVALLSMLFYvAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVAHfhngfsywiyg 443
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1188401072 408 -MYIAAAItFVglvvsWWLAPETNARSLADASSLDNEASQKA 448
Cdd:PRK10077  444 cMGVLAAL-FM-----WKFVPETKGKTLEEMEALWEPETKKT 479
 
Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
20-423 1.67e-46

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 164.31  E-value: 1.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  20 TVRSGGGSFVDGYVLSIIGIAMMKVSPA--LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCS 97
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  98 VAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPD-AWRL 176
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwGWRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 177 TLASTAVIGALLFLVRmgtpesprwliskgrhaeaeaiirkvygpdfglgnlpeqaesknlsffnllhsgygKRMAFVAI 256
Cdd:cd17316   161 LFLIGALPALLALLLR--------------------------------------------------------RRTLLLIL 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 257 FWTCSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLR 335
Cdd:cd17316   185 LWFFISFGYYGLTTFLPTYLqTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 336 DGPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASL-QSLGIGTTMYIAAAI 414
Cdd:cd17316   265 SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLaSTGGTGVPALILALL 344

                  ....*....
gi 1188401072 415 TFVGLVVSW 423
Cdd:cd17316   345 AIVALIVAL 353
Sugar_tr pfam00083
Sugar (and other) transporter;
26-434 6.28e-37

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 140.87  E-value: 6.28e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  26 GSFVDGYVLSIIG--IAMMKV---------SPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFV 94
Cdd:pfam00083   8 GGFLFGYDTGVIGafLTLIDFfknfglsksVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  95 VCSVAQYWVQSG---EMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGP 171
Cdd:pfam00083  88 IGAVLQGAAKGKwsvYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 172 DAWRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQAESKNLS------FFNLLHS 245
Cdd:pfam00083 168 DGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGqeaekaSWKELFS 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 246 GYGKRMAF---VAIFWTCSVIPVFAVYAFAPKVLDALHLSGkwGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQS-- 320
Cdd:pfam00083 248 TKTRRQRLligVMLQIFQQLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGaa 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 321 -------FLWSGLALLLLGLLRDGPSMI--ILLMFGAYALFIGGaqvLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVG 391
Cdd:pfam00083 326 gmaicfvILGIVALLGVSKSDWAGIVAIvfIALFIAFFAMGWGP---VPWVIVSELFPLSVRSKAMALATAANWLANFLI 402
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1188401072 392 TWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLAPETNARSL 434
Cdd:pfam00083 403 GFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTL 445
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
25-429 2.95e-30

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 120.87  E-value: 2.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  25 GGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQ 104
Cdd:cd17371     6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 105 SGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALL-HFGGPDAWRLTLASTAV 183
Cdd:cd17371    86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpLLPPEIAWRVLFLLGAL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 184 IGALLFLVRMGTPESPRWLISKGRHAEAEAIIrkvygpdfglgnlpeqaesknlSFFNLLHSGYGKRMAFVAIFWTCSVI 263
Cdd:cd17371   166 PALLVLFIRRFVKEPPQWQAARAARRHFADRP----------------------SLRELFSPPLLRTTLLASLLATGALG 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 264 PVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMII 342
Cdd:cd17371   224 GYYGITTWLPSYLtGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLIL 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 343 LLMFgAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVS 422
Cdd:cd17371   304 ILGF-PLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382

                  ....*..
gi 1188401072 423 WWLAPET 429
Cdd:cd17371   383 ALLLPET 389
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
11-429 2.32e-29

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 118.05  E-value: 2.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  11 PLNRFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGP 90
Cdd:COG2271     3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  91 TLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGG 170
Cdd:COG2271    83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 171 pdaWRLTLASTAVIGALLFLVRMgtpesprWLIskgrhaeaeaiirkvygpdfglgnlpeqaesknlsffnllhsgygkr 250
Cdd:COG2271   163 ---WRAAFLILGLPGLLLALLRF-------WLL----------------------------------------------- 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 251 mafvAIFWTCSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALL 329
Cdd:COG2271   186 ----ALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 330 LLGLLRDGPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMY 409
Cdd:COG2271   262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
                         410       420
                  ....*....|....*....|
gi 1188401072 410 IAAAITFVGLVVSWWLAPET 429
Cdd:COG2271   342 LLAALALLAALLALLLLRET 361
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
7-395 5.88e-28

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 114.76  E-value: 5.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072   7 VEDVPLNRFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLY 86
Cdd:TIGR00895   6 IRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  87 FVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALL 166
Cdd:TIGR00895  86 LWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 167 -HFGgpdaWRLTLASTAVIGALLFLVRMGT-PESPRWLISKGRHAEAEAI----IRKVYGPDFGLGNLPEQAESKNLSFF 240
Cdd:TIGR00895 166 pVFG----WRSLFYVGGIAPLLLLLLLMRFlPESIDFLVSKRPETVRRIVnaiaPQMQAEAQSALPEQKSTQGTKRSVFK 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 241 NLLHSGYGKRMAFVAIFWTCSVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQS 320
Cdd:TIGR00895 242 ALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLL 321
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1188401072 321 FLWSGLALLLLGLLRDGPSMIILLMFgaYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLV 395
Cdd:TIGR00895 322 LLGAVFAVLVGSTLFSPTLLLLLGAI--AGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILA 394
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
26-428 2.94e-26

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 109.58  E-value: 2.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  26 GSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQS 105
Cdd:cd17359     9 GGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPN 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 106 GEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPD-----AWRLTLAS 180
Cdd:cd17359    89 FTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADwlgaeGWRWMLGL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 181 TAVIGALLFLVRMGTPESPRWLISKGRHAeaeAIIrkvygpdfGLGnlpeqaesknLSFFNllhsgygkrmafvaifwtc 260
Cdd:cd17359   169 EAIPAILFLLGMLFIPESPRWLVSKGKPI---LII--------GIG----------LAIFQ------------------- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 261 SVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLL-------QSFLWSGLALLLLGL 333
Cdd:cd17359   209 QFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLigsigmaISLLLIGTAFYFAPG 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 334 LRDGPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAA 413
Cdd:cd17359   289 SQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAV 368
                         410
                  ....*....|....*
gi 1188401072 414 ITFVGLVVSWWLAPE 428
Cdd:cd17359   369 ICVLAFLFVWKFVPE 383
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
56-434 3.35e-26

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 110.89  E-value: 3.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  56 GLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWV---QSGEMLFALRFLNGVAVGIEYPVATAFLV 132
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAafaLSVEMLIVGRVLLGIGVGIASALVPMYLS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 133 EFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHAEAE 212
Cdd:TIGR00879 154 EIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEAR 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 213 AIIRKVYG---PDFGLGNL-----------PEQAESKNLSFFNLLHSGYGKRMAFVAIFWTCSVIPVFAVYAFAPKVLDA 278
Cdd:TIGR00879 234 KSLARLRGtsgEDKELLDElelidikrsieKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFEN 313
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 279 LHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSF------LWSGLALLLLGLLRDGPS----MIILLMF-- 346
Cdd:TIGR00879 314 AGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAagmaicLFVLGILGASFVTGSSKSsgnvAIVFILLfi 393
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 347 GAYALFIGGaqvLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLA 426
Cdd:TIGR00879 394 AFFAMGWGP---VPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFL 470

                  ....*...
gi 1188401072 427 PETNARSL 434
Cdd:TIGR00879 471 PETKGRTL 478
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
76-432 3.85e-25

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 107.35  E-value: 3.85e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQ---YWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGP-----CLA-T 146
Cdd:cd17357    72 LANRFGRKNGLLISNALLVVSSLLMflsKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGAlgsltQIGvT 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 147 LTILWFAGAAAAYMLGeallhfgGPDAWRLTLASTAVIGALLFLVRMGTPESPRWL-ISKGRHAEAEAIIRKVYGPDFGL 225
Cdd:cd17357   152 LGILLGQVFGLPSVLG-------TETLWPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDEEEAEKSLKFLRGIEDDV 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 226 GN-----LPEQAESKNLSFFNLLH----SGYGKRMAFVAIFWTC-SVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITL 295
Cdd:cd17357   225 DQeleeiKKESEQMGDQKQVSLMQllrdPSLRLPLLLVLVVSASqQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGI 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 296 LFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLQLV-------YPNEIF 368
Cdd:cd17357   305 VNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGlgpipwfIGAELF 384
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1188401072 369 PTEIRAGAVGVGTSLSRIGAAVGTWLVPaSLQSLGIGTTMYIAAAITFVGLVVSWWLAPETNAR 432
Cdd:cd17357   385 PQAPRSAAQSLGSSVNWTSNFIVGMAFP-PLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKGR 447
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-390 7.16e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 99.28  E-value: 7.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  14 RFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLF 93
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  94 VVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGpda 173
Cdd:COG2814    86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG--- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 174 WRLTLASTAVIGAL-LFLVRMGTPESPRWLISKGRHAEAEAIIRkvygpdfglgnlpeqaesknlsffnllhsgygKRMA 252
Cdd:COG2814   163 WRWVFLVNAVLALLaLLLLLRLLPESRPAARARLRGSLRELLRR--------------------------------PRLL 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 253 FVAIFWTCSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLL 331
Cdd:COG2814   211 LLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1188401072 332 GLLRDGPSMIILLMFgaYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAV 390
Cdd:COG2814   291 ALAGSLWLLLLALFL--LGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
26-428 3.91e-22

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 97.26  E-value: 3.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  26 GSFVDGYVLSIIGIA--MMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWV 103
Cdd:cd17315     5 GGLLFGYDLGVINGAllYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 104 QSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGpclaTLTILW----FAGAAAAYMLGEAlLHFGGPDAWRLTLA 179
Cdd:cd17315    85 PNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRG----ALGTLNqlmiTFGILLAYLLGLA-LSLSPPGWWRLMFA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 180 STAVIGALLFLVRMGTPESPRWLISKGrhaeaeaiirkvygpdfglgnlpeqaesknLSFFNLLhSGygkrmafvaifwt 259
Cdd:cd17315   160 LAAVPALLQLLLMFFLPESRALLVGVG------------------------------LQLLQQL-TG------------- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 260 csvIPVFaVYaFAPKVLDALHlSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFL---WSGLALLLLGLLRD 336
Cdd:cd17315   196 ---INAV-MY-YAPTIFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAgmaASLLLLAIAFLLPA 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 337 GPSMIILLMFGAYALFIG----GAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAA 412
Cdd:cd17315   270 LAKAAGWLALLGILLYIAafamGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFA 349
                         410
                  ....*....|....*.
gi 1188401072 413 AITFVGLVVSWWLAPE 428
Cdd:cd17315   350 AVCLLALVFVFFFVPE 365
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
76-436 5.23e-22

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 98.03  E-value: 5.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17358    64 LADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGI 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALlhfggpdAWRLTlastAVIGALLFLVRMGT----PESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQ 231
Cdd:cd17358   144 LLGYVLGSFL-------PWRTL----ALIGAIPPVVFLILlffiPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAE 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 232 ---------AESKNLSFFNLLHSGYGKRMAFVAIFWTCS-VIPVFAVYAFAPKVLDALHlSGKWGSYGSVAITLLFVVGC 301
Cdd:cd17358   213 iqeelaeleKEAKESSFSDLFQRKYLKPLVIGLGLMLFQqLSGINAVIFYASSIFDEAG-SGLDPNTATIIIGVVQVVGT 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 302 VIATRLVNTLGRRKLLLQS-------------FLWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLQLVypnEIF 368
Cdd:cd17358   292 LVATLLVDRLGRRPLLLVSaigmgigllalglYFYLQEHGALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMS---EIF 368
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1188401072 369 PTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLAPETNARSLAD 436
Cdd:cd17358   369 PAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
76-436 2.99e-20

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 93.16  E-value: 2.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFV---GPTLFVVCSVA--QYWvqsgeMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTIL 150
Cdd:TIGR00898 150 LSDRFGRKKVLLLstlVTAVSGVLTAFspNYT-----VFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 151 WFAGAaaaymLGEALLHFGGPDaWRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHAEAEAIIRKVYG------PDFG 224
Cdd:TIGR00898 225 FSLGL-----VLLPLVAYFIPD-WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKingkklPAEV 298
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 225 LGNLPEQAESKNL---SFFNLLHSGYGKRMAFVAIF-WTCSvipVFAVYAFapkvldALHLSGKWGS-YGSVAIT-LLFV 298
Cdd:TIGR00898 299 LSLSLEKDLSSSKkqySFLDLFRTPNLRKTTLCLMMlWFTT---AFSYYGL------VLDLGNLGGNiYLDLFISgLVEL 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 299 VGCVIATRLVNTLGRRKLLLQSFLW-SGLALLLLGLLRDGPSMIILLMFGAYAlFIGGAQVLQLVYPNEIFPTEIRAGAV 377
Cdd:TIGR00898 370 PAKLITLLLIDRLGRRYTMAASLLLaGVALLLLLFVPVDLYFLRTALAVLGKF-GITSAFQMVYLYTAELYPTVVRNLGV 448
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1188401072 378 GVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVswwLAPETNARSLAD 436
Cdd:TIGR00898 449 GVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTL---FLPETKGVPLPE 504
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
23-429 8.39e-19

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 87.72  E-value: 8.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  23 SGGGSFVDGYVLSIIGIAMMKVS-----PALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCS 97
Cdd:cd17364     4 AGMGFFTDAYDLFSISLVTKILGrlyygGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  98 VAQYWVQSGE------MLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILW----FAGAAAAYMLGEALLH 167
Cdd:cd17364    84 ILSALSPGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQgfgiLAGAIVTLILSAIFEH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 168 FGGPD-------AWRLTLASTAVIGALLFLVRmgtpesprwliskgRHAEAEAIIRKVYGPDFGLGNLpeqaesknlsff 240
Cdd:cd17364   164 PLPAGtyhhadlVWRIVLGLGAIPALSVLYFR--------------KHLLGTAGTWFLLDIAFYGQNL------------ 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 241 nllhsgYGKRMaFVAIFWTCSVIPVFAVYAFApkvldalhlsgkwgSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQS 320
Cdd:cd17364   218 ------FQSTI-ISAIGFSKTMNAYQELFNIA--------------VGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMG 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 321 FLWSGLALLLLGLLRDGPSMIILLMFGAYAL--FIG--GAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVP 396
Cdd:cd17364   277 FFGMTIFLLILAGPYDHWKISTIGFFVLYGLtfFFSnfGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFL 356
                         410       420       430
                  ....*....|....*....|....*....|...
gi 1188401072 397 ASLQSLGIGTTMYIAAAITFVGLVVSWWLAPET 429
Cdd:cd17364   357 SLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
6-229 3.92e-18

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 84.48  E-value: 3.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072   6 SVEDVPLNRFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRML 85
Cdd:COG0477     2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  86 YFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEAL 165
Cdd:COG0477    82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1188401072 166 LHFGGpdaWRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLP 229
Cdd:COG0477   162 VAALG---WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLL 222
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
48-426 1.69e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.78  E-value: 1.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  48 LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVA 127
Cdd:cd17325    26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAA 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 128 TAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLFLVRMGTPESPRWLISKGR 207
Cdd:cd17325   106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSA 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 208 HAEAEAIIRKVYGPDFGLGNLpeqaesknlsffnllhsgygkrMAFVAIFWTCSVIPVFAVYAfapkvLDALHLSGKWGS 287
Cdd:cd17325   186 ARLRSGLRLLLRDRRLLALFL----------------------AIFVLAFAFGALEPFLPLYA-----AELGGLSPAQIG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 288 YGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFgaYALFIGGAQVLQLVYPNEI 367
Cdd:cd17325   239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL--LGLGLGLVFPATLALLADI 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1188401072 368 FPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLA 426
Cdd:cd17325   317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
23-428 3.42e-17

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 82.70  E-value: 3.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  23 SGGGSFVDGYVLSIIGIAMMKVSPALG---LTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVA 99
Cdd:cd17360     2 AGIGGFLFGYDTGVISGALLYIKDDLGevvLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 100 QYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFggPDAWRLTLA 179
Cdd:cd17360    82 MAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYL--PGGWRWMLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 180 STAVIGALLFLVRMGTPESPRWliskgrhaeaEAIIRKVYgpdFGLGnlpeqaesknLSFFNLLhSGYGKRMAFVAIfwt 259
Cdd:cd17360   160 LAAVPAVLQFIGLLFLPESPRW----------PSTRRALI---VGCG----------LQAFQQF-SGINTVMYYSAT--- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 260 csvipVFAVYAFAPKVLdALHLsgkwgsygSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFlwsglallllgllrdgPS 339
Cdd:cd17360   213 -----ILQMAGFKDNQN-AIWL--------SLIVAGTNFIFTIVGMYLIDKFGRRKLLLISL----------------FG 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 340 MIILLMFGAYALFIGGAQVLQLVYP-----------NEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTM 408
Cdd:cd17360   263 VIVALVVLAVWLALVGLILYLAFFApgmgpvpwtvnSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTF 342
                         410       420
                  ....*....|....*....|
gi 1188401072 409 YIAAAITFVGLVVSWWLAPE 428
Cdd:cd17360   343 LLFAGLAVLGLIFIYFCVPE 362
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
27-425 1.05e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.38  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  27 SFVDGYVLSIIGIAMMKvspALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSG 106
Cdd:COG2223    17 AFGVWYLWSVLAPPLAE---EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 107 EMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGpcLAT-LTILWF-AGAAAAYMLGEALLHFGGPDAWRLTLASTAVI 184
Cdd:COG2223    94 WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG--LALgLAAGGGnLGAAVAAFLAPLLIAAFGWRNAFLILGILLLV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 185 GALLFLVRMGTPESPRWLISKGRHAEAEAIIRKvygpdfglgnlpeqaesknlsffnllhsgygKRMAFVAIFWTCSVIP 264
Cdd:COG2223   172 VAVLAWLFLRDPPAGAAAAAKASLRDQLEALRD-------------------------------PRFWLLSLLYFGTFGS 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 265 VFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMIIL 343
Cdd:COG2223   221 FIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLV 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 344 LMFGAYALFIGG-AQVLQLVYpnEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLG-IGTTMYIAAAITFVGLVV 421
Cdd:COG2223   301 LFLLLGLALGGGnGAVFALVP--DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378

                  ....
gi 1188401072 422 SWWL 425
Cdd:COG2223   379 TLLL 382
xylE PRK10077
D-xylose transporter XylE; Provisional
48-448 7.10e-15

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 76.66  E-value: 7.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  48 LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYW-------VQSGEMLFALRF-----L 115
Cdd:PRK10077   50 ESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWpefgftsIGPDNTGYVPEFviyriI 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 116 NGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLhfGGPDA-------WRLTLASTAVIGALL 188
Cdd:PRK10077  130 GGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIA--RSGDAswlntdgWRYMFASEAIPALLF 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 189 FLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPDFG---LGNLPEQAESKNLSFFNLLhsGYGKRMAFVAIFwtCSVIPV 265
Cdd:PRK10077  208 LMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLAtqaLQEIKHSLDHGRKTGGKLL--MFGVGVIVIGVM--LSVFQQ 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 266 F----AVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSG--LALLLLGLLRDGPS 339
Cdd:PRK10077  284 FvginVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAigMFSLGTAFYTQAPG 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 340 MIILLMFGAY-ALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTT----------- 407
Cdd:PRK10077  364 IVALLSMLFYvAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVAHfhngfsywiyg 443
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1188401072 408 -MYIAAAItFVglvvsWWLAPETNARSLADASSLDNEASQKA 448
Cdd:PRK10077  444 cMGVLAAL-FM-----WKFVPETKGKTLEEMEALWEPETKKT 479
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
24-421 1.05e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 75.54  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  24 GGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWV 103
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 104 QSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPDaWRLTLASTAV 183
Cdd:cd06174    82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG-WRAVFLIAAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 184 IGALLFLVRMGTPESPRWLISKGRHAEAEAIIRKvygpdfglgnlpeqaesknlSFFNLLHSgygKRMAFVAIFWTCSVI 263
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLK--------------------LLKRVLKN---PGLWLLLLAIFLVNL 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 264 PVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMII 342
Cdd:cd06174   218 AYYSFSTLLPLFLlDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1188401072 343 LLMFgAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVV 421
Cdd:cd06174   298 LLLL-LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
MFS_1 pfam07690
Major Facilitator Superfamily;
26-392 5.84e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.84  E-value: 5.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  26 GSFVDGYVLSIIGIAM-MKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQ 104
Cdd:pfam07690   4 AAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 105 SGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGpdaWRLTLASTAVI 184
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---WRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 185 GALLFLVRMGTPESPRwliskgrhaeaeaiirkvygpdfglGNLPEQAESKNLSFFNLLHSGYGKRMAFVAIFWTCSVIP 264
Cdd:pfam07690 161 SLLAAVLLLLPRPPPE-------------------------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 265 VFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQS----FLWSGLALLLLGLLRDGPSM 340
Cdd:pfam07690 216 FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAllllILAALGLLLLSLTLSSLWLL 295
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1188401072 341 IILLMFGayaLFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGT 392
Cdd:pfam07690 296 LALLLLG---FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
29-421 2.43e-13

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 71.08  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  29 VDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEM 108
Cdd:cd17365    10 LDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 109 LFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALL-HFGgpdaWRLTLASTAVIGAL 187
Cdd:cd17365    90 LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIpAFG----WRSVFLLGGVPPLI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 188 LFLVRMGTpesprwliskgrhaeaeaiirkvygpdfglgnlpeqaesknlsffnllhsgygkrmafvAIFWTCSVIPVFA 267
Cdd:cd17365   166 LLPLLRGT-----------------------------------------------------------LLLWVTFFMGLLL 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 268 VYA---FAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILL 344
Cdd:cd17365   187 VYLlnsWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVL 266
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1188401072 345 MFGAyALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVpASLQSLGIGTTM--YIAAAITFVGLVV 421
Cdd:cd17365   267 VFLA-GACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLG-GLLLAAGLGPESvfLALAIPAALGALA 343
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
76-231 3.70e-13

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 70.98  E-value: 3.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17363    57 LADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGG 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALL-HFGGP---------DAWRL-----TLASTAVIGALLFLvrmgtPESPRWLISKGRHAEAEAIIRKVYG 220
Cdd:cd17363   137 LYASAMAWAIIpHYGWGfsmgtayqfHSWRVfvivcALPSVASVVALTFM-----PESPRFLLEVGKHDEAWMILKQVHD 211
                         170
                  ....*....|.
gi 1188401072 221 PDFGLGNLPEQ 231
Cdd:cd17363   212 TNMRAKGHPER 222
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
14-236 8.77e-13

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 70.39  E-value: 8.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  14 RFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLF 93
Cdd:TIGR01299 163 RFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVN 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  94 VVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALL-HFGGP- 171
Cdd:TIGR01299 243 GFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIpHYGWSf 322
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1188401072 172 --------DAWRL-----TLASTAVIGALLFLvrmgtPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQAESKN 236
Cdd:TIGR01299 323 qmgsayqfHSWRVfvivcAFPCVFAIGALTFM-----PESPRFFLENGKHDEAWMILKLIHDTNMRAKGHPEKVFSVN 395
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
30-231 1.83e-12

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 69.18  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  30 DGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEML 109
Cdd:cd17438    11 DGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 110 FALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAA-AAYMLGEALLHFG-----GPD----AWRL--- 176
Cdd:cd17438    91 LFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLyASAMAWSIIPHYGwgfsmGTNyhfhSWRVfvi 170
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1188401072 177 --TLASTAVIGALLFLvrmgtPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQ 231
Cdd:cd17438   171 icALPCIASIIALKFM-----PESPRFLLEMGKHDEAWMILKNIHDTNMRAKGTPEK 222
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
31-436 2.17e-12

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 68.20  E-value: 2.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  31 GYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLF 110
Cdd:cd17437    10 GYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 111 ALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLFL 190
Cdd:cd17437    90 VGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLHVGWRLMLGVGAVPSLFLAI 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 191 VRMGTPESPRWLISkgrhaeaeaiIRKVYGPDFGLgNLPEQAesknlsffnllhSGygkrmafvaifwtcsvipVFAVYA 270
Cdd:cd17437   170 GVLAMPESPRWTPA----------VRRMLIAALGI-HFFQQA------------SG------------------IDAVVL 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 271 FAPKVLDALHLSGKWGSYG-SVAITLLFVVGCVIATRLVNTLGRRKLLLQS-----FLWSGLALLLLGLLRDGPS----- 339
Cdd:cd17437   209 YSPRIFKKAGIKSKDKLLLaTVAVGVTKTLFILVATFLLDKVGRRPLLLTStggmtLSLTALATSLTFIDRNGGGltwal 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 340 -MIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVG 418
Cdd:cd17437   289 vLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAA 368
                         410
                  ....*....|....*...
gi 1188401072 419 LVVSWWLAPETNARSLAD 436
Cdd:cd17437   369 WVFFYFFLPETKGKSLEE 386
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
30-234 4.72e-12

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 67.75  E-value: 4.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  30 DGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEML 109
Cdd:cd17439    11 DGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 110 FALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALL-HFGGP---------DAWRL--- 176
Cdd:cd17439    91 LFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIpHYGWSfqmgsayqfHSWRVfvl 170
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 177 --TLASTAVIGALLFLvrmgtPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQAES 234
Cdd:cd17439   171 vcAFPSVFAIGALTTM-----PESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFS 225
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
6-438 1.31e-11

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 66.29  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072   6 SVEDVPLNRFHRLLTVRSGGGSFVDGYVLSIIGIammkVSPALGLTaFWEG----------LIAASALIGIFFGGFIGGA 75
Cdd:TIGR00887   4 EADTAPFGWQHFRAIVIAGVGFFTDSYDLFCISL----VTKMLGYV-YYHGkgplpssvsaAVNGSASIGTLAGQLFFGW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGE------MLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTI 149
Cdd:TIGR00887  79 LADKLGRKRVYGMELIIMIIATVASGLSPGSSpksvmaTLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 150 LWFAGAAAAYMLGEALL-----------HFGGPDA---------WRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHA 209
Cdd:TIGR00887 159 MQGFGILAGAIVALIVLagfkhsleaaaDEASCTGscvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 210 EAEAIIRKVYGPDFGLGNLPE------QAESKNLSFFNLL-HSG---YGKRMAFVAIFWTCSVIPVFAVYAFAPKVLDAL 279
Cdd:TIGR00887 239 EQAASDMSAVLQVKIEAEPDEvekastAVEVPKASWSDFFtHFFkwrHGKHLLGTAGSWFLLDIAFYGVNLNQKVILSAI 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 280 HLSGKWGSYG--------SVAITLLFVVGCV----IATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFG 347
Cdd:TIGR00887 319 GYSPPAATNNayeelyktAVGNLIIALAGTVpgywVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFAYNHLSTHGFLAIY 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 348 AYALFIG--GAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQS----------LGIGTTMYIAAAIT 415
Cdd:TIGR00887 399 VLAQFFAnfGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHgdptkgyptgIWMGHVLEIFALFM 478
                         490       500
                  ....*....|....*....|...
gi 1188401072 416 FVGLVVSwWLAPETNARSLADAS 438
Cdd:TIGR00887 479 FLGILFT-LLIPETKGKSLEELS 500
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
49-435 2.57e-11

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 65.07  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  49 GLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVAT 128
Cdd:cd17362    35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAP 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 129 AFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGpdAWRLTLASTAVIGALLFLVRMGTPESPRWlisKGRH 208
Cdd:cd17362   115 VYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVG--GWRYMYGLAAPPALLLGIGMWFLPPSPRW---QGNY 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 209 AEAEAIirkvygpdfGLGnlpeqaesknlsffnllhsgygkrmafVAIFWTCSVIPvfAVYAFAPKVLDALHLSGKWGSY 288
Cdd:cd17362   190 RKPLII---------GLG---------------------------LVLFQQITGQP--SVLYYAATIFKSAGFSAASDAT 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 289 G-SVAITLLFVVGCVIATRLVNTLGRRKLLLQSF----LWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQV----L 359
Cdd:cd17362   232 LvSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVsgmvVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQIsfgpI 311
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1188401072 360 QLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLAPETNARSLA 435
Cdd:cd17362   312 SWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLE 387
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
76-434 6.59e-11

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 63.74  E-value: 6.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17433    64 IVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGI 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALlhfggpdAWRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQAE-- 233
Cdd:cd17433   144 MGAYLAGLVL-------DWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEqs 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 234 ----SKNLSFFNLLHSGYGKRMAF-VAIFWTCSVIPVFAVYAFAPKVLDALHLsgKWGSYGSVAITLLFVVGCVIATRLV 308
Cdd:cd17433   217 fhleEQSFSLALLKQPGIYKPLIIgVSLMAFQQLTGINAVMFYAETIFEEAKF--KDSSVASVIVAAIQVLFTAVAALIM 294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 309 NTLGRRKLLLQSFLWSGLALlllgllrdgpSMIILLMFGAYALFIGGAQV----LQLVYPNEIFPTEIRagavGVGTSLS 384
Cdd:cd17433   295 DRAGRKVLLVLSGVVMVFST----------AAFGWLAVGSMGFFIAGFAVgwgpIPWLVMSEIFPLHVR----GVASGIC 360
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1188401072 385 RIGAAVGTWLVPASLQS----LGIGTTMYIAAAITFVGLVVSWWLAPETNARSL 434
Cdd:cd17433   361 VLTNWLMAFLVTKEFSSlmevLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTL 414
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
27-423 8.84e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 60.28  E-value: 8.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  27 SFVDGYVLSIIGIAMMKvspALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSG 106
Cdd:cd17319    15 NYLDRVNISVAAPTIMK---DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 107 EMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAA-AAYMLGEALLHFGgpdaWRLTLASTAVIG 185
Cdd:cd17319    92 TSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAiGPPLSGWLLLLFG----WRWAFIIEGLLG 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 186 ALLFLVrmgtpesprWLIskgrhaeaeaiirkvygpdfglgnlpeqaesknlsffnllhsgYGKRMAFVAIFWTCSVIPV 265
Cdd:cd17319   168 LLLAVL---------WWF-------------------------------------------YLRQVWGLALGYFGINYAL 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 266 FAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTL--GRRKLLLQSFLWSGLALLLLGLLRDGPSMII 342
Cdd:cd17319   196 YGLLTWLPTYLkQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAV 275
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 343 LLMFGAYAlFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTT-MYIAAAITFVGLVV 421
Cdd:cd17319   276 ILLSLAGF-GIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAaFLFLAAVALLAALL 354

                  ..
gi 1188401072 422 SW 423
Cdd:cd17319   355 VL 356
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
75-428 1.53e-09

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 59.57  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  75 ALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGpclaTLTILwFAG 154
Cdd:cd17361    73 YVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRG----ALNIG-FQL 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 155 AAAAYMLGEALLHFG----GPDAWRLTLASTAVIGALLFLVRMGTPESPrwliskgrhaeaeaiirkvygpdfglgNLPE 230
Cdd:cd17361   148 AITIGILIANLINYGtskiKPNGWRLSLGLAAVPALILLLGSLFLPETP---------------------------NSPQ 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 231 QAesknlsffnllhsgygkrMAFV-AIFWTCSVIPVFAVYafAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVN 309
Cdd:cd17361   201 LV------------------IAILiPFFQQLTGINVIMFY--APVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVD 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 310 TLGRRKLLLQS--------FLWSGLALLLLGLLRDGP---SMIILLMFGAYALFIGGA-QVLQLVYPNEIFPTEIRAGAV 377
Cdd:cd17361   261 RFGRRFLLLEGgvqmlasqVAIGILLAVKFGDGGELPkayAIAVVVLICLYVAAFAWSwGPLGWLVPSEIFPLETRSAGQ 340
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1188401072 378 GVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAItFVGLVVSWWLAPE 428
Cdd:cd17361   341 SLTVAVNFLFTFVIAQAFLSMLCAMKFGIFLFFAGWV-VVMSLFVYFLLPE 390
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
75-423 1.54e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.49  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  75 ALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAG 154
Cdd:cd17324    56 PLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLG 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 155 AAAAYMLGEALLHFGGpdaWRLTLASTAVIGALLFLVRMgtpesprwliskgrhaeaeaiirkvygpdFGLGNLPEQAES 234
Cdd:cd17324   136 LVLGRPLGGLLGQLLG---WRAAFLAIAVLALLAALLLW-----------------------------RLLPSLPPKKPG 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 235 KNLSFFNLLHSGYGKRMAFVAIFWTCSVIPVFAVYAF-APKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGR 313
Cdd:cd17324   184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYlAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 314 RKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFgaYALFIGGAQVLQLVYPNEIFPtEIRAGAVGVGTSLSRIGAAVGTW 393
Cdd:cd17324   264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVL--WGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAA 340
                         330       340       350
                  ....*....|....*....|....*....|
gi 1188401072 394 LVPASLQSLGIGTTMYIAAAITFVGLVVSW 423
Cdd:cd17324   341 LGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
76-429 2.43e-09

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 58.85  E-value: 2.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCS--------VAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATL 147
Cdd:cd17367    63 LADRIGRRAALTLSVSLMAAGSlviavtptYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQ 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 148 TILWFAGAAAAYMLGEALLHFGGPD-----AWRLTLASTAVIGALLFLVRMGTPESPRWLISKGRHAEAEAIIRkvygpd 222
Cdd:cd17367   143 YVTLIGGQLLALGVLLVLQHTLGEDqmaawGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLR------ 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 223 fGLGNLPEQAesknLSFFNLLhsgygkrMAFVAIFWTCSV-IPVFAVyafapkvlDALHLSGKWGSYGSVAITLLFVVGC 301
Cdd:cd17367   217 -ELRRHPREL----LLVVGLT-------AGGTLAFYTWTTyLQKFLV--------NTAGFSKGDATWITTAALLVFMLLQ 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 302 VIATRLVNTLGRRKLLLQSF-LWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQV-LQLVYPNEIFPTEIRAGAVGV 379
Cdd:cd17367   277 PLGGRLSDRIGRRPLLLFFGiGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTsINAVVKAELFPTHVRALGVGL 356
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1188401072 380 GTSLSRI---GAA--VGTWlvpasLQSLGIGTTMYIAAAITFVGLVVSWWLAPET 429
Cdd:cd17367   357 PYALAVAifgGTApyVALW-----LKSIGHEWVFFWYVAGLIAISLVVYLRMPET 406
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
31-425 1.22e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 56.85  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  31 GYVLSIIGIAMMKVSPALGLT-----AFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFV-----GPTLFVVCSVAQ 100
Cdd:cd06173     7 AQLLSALGDWIFTVALPWLVLqltgsALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLAL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 101 YWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPdAWRLTLAS 180
Cdd:cd06173    87 LGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP-GGAFAINA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 181 TAVIGALLFLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPDFGLgnlpeqaesknlsffnllhsgygkRMAFVAIFWTC 260
Cdd:cd06173   166 LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLL------------------------RLLLLALALFA 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 261 SVIPVFAVyAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSM 340
Cdd:cd06173   222 LLGGALTV-LLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 341 IILLMFgaYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLV 420
Cdd:cd06173   301 LAALFL--LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378

                  ....*
gi 1188401072 421 VSWWL 425
Cdd:cd06173   379 LLLLL 383
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
76-436 1.23e-08

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 56.86  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQ---SGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWF 152
Cdd:cd17432    73 LVIRLGRKGTLLLNNIFAIVAAILMGLSKiakSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFIT 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 153 AGAAAAYMLG-EALLhfGGPDAWRLTLASTAVIGALLFLVRMGTPESPRW-LISKGRHAEAEAIIRKVYGPDFGLGNLPE 230
Cdd:cd17432   153 LGILLGQVLGlRELL--GNEEGWPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLRGKEDVDDEMEE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 231 -QAES------KNLSFFNLLhSGYGKRMAFVAIFWTCSVIP---VFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVG 300
Cdd:cd17432   231 mLEEQraekgvGTVSVLELF-RDRSVRWQLISIIVLMAGQQlcgINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLA 309
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 301 CVIATRLVNTLGRRKLLLQSF----LWSGLALLLLGLLRDGPSMIILLMFGAYALFIG---GAQVLQLVYPNEIFPTEIR 373
Cdd:cd17432   310 TITCVLVIERLGRRPLLIGGFglmaVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASfgiGPAGVPFILTTEIFDQSSR 389
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1188401072 374 AGAVGVGTSLSRIGA-AVGtwLVPASLQSlGIGTTMYIA-AAITFVGLVVSWWLAPETNARSLAD 436
Cdd:cd17432   390 PAAFMVAGSLNWLSNfLVG--LLFPFIQE-GLGAYCFLVfAVICLLTAIYIFFVLPETKGKTFLE 451
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-432 1.55e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 56.40  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  13 NRFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTL 92
Cdd:COG0738     3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  93 FVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEfLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPD 172
Cdd:COG0738    83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 173 AWRLTLASTAVIGALLFLVrmgtpesprWLISKGRHAEAEaiirkvygpdfglgnlPEQAESKNLSFFNLLHSgygKRMA 252
Cdd:COG0738   162 SWHLPYLILAVLLLLLALL---------FLRSKLPEIEEE----------------EEEAAGSAASLKSLLKN---PRLL 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 253 FVAIFWTCSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLL 331
Cdd:COG0738   214 LGGLAIFLYVGAEGAIGDWLPLYLkDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 332 GLLrdGPSMIILLMFGAYALFIGgaqvlqLVYPNeIFPTEIR------AGAVGVGTSLSRIGAAVGTWLVPASLQSLGIG 405
Cdd:COG0738   294 LLA--PGPWLALIGLALVGLGLS------LMFPT-IFSLALDglgkrtAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLR 364
                         410       420
                  ....*....|....*....|....*..
gi 1188401072 406 TTMYIAAAITFVGLVVSWWLAPETNAR 432
Cdd:COG0738   365 AAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
76-434 1.64e-08

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 56.49  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGE-MLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAG 154
Cdd:cd17356    68 LSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWyQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIG 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 155 AAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLFLVRMGTPESPRWLiSKGRHAEAEAIIRKVYGPDFGLGNLPEQAES 234
Cdd:cd17356   148 ILVAYCINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL-YRTILGIMLQLFQQLTGINYFFYYGTTIFQS 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 235 KNLSFFNLLHSGygkrMAFVAIFWTCSVIPVFAVYAFAPKVLdaLHLSGKWGSygsvaiTLLFVVGCVIATRLVNTLgrr 314
Cdd:cd17356   227 TGLTGSSPLLTS----IILYIVNFVSTIPGLFFVDKFGRRTC--LLIGAAGMS------ICLFIYAAVGVRYLIPNP--- 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 315 klllqsflwsglaLLLLGLLRDGPSMIIL--LMFGAYALFIGGAqvlQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGT 392
Cdd:cd17356   292 -------------QSGTSNKSAGNGMIVFicLFIFSFATTWGPI---AWVYVAEVFPLRVRSKGMALATAFNWLWNFLIS 355
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1188401072 393 WLVPASLQSLGiGTTMYIAAAITFVGLVVSWWLAPETNARSL 434
Cdd:cd17356   356 FFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTL 396
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
76-425 3.03e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 55.28  E-value: 3.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGpCLATLTILWFAGA 155
Cdd:cd17317    48 LADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRS-FVGILFGLFWALG 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYmlgeALLHFGGPDaWRLTLASTAVIGALLFLVRMGTPesprwliskgRHAEAEAIIRKV-----YGPDFGLGNLpe 230
Cdd:cd17317   127 YMLL----ALLAYLIRD-WRWLQLAISLPGLLFLLLLWWLP----------RRTIIVGLIWFVtslvyYGLSLNSSNL-- 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 231 qAESKNLSFFnllhsgygkRMAFVAIfwtcsvipvfavyafapkvldalhlsgkwgsygsvaitllfvVGCVIATRLVNT 310
Cdd:cd17317   190 -GGNLYLNFF---------LSGLVEI------------------------------------------PAYFLALLLLDR 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 311 LGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAV 390
Cdd:cd17317   218 LGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAIL 297
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1188401072 391 GTWLVpaSLQSLGIGTTMYIAAAITFVGLVVSWWL 425
Cdd:cd17317   298 APFIV--LLGKIGPLLPLIIFGVLALLGGLLTLLL 330
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
76-231 4.96e-08

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 54.92  E-value: 4.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17440    57 LADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGG 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALL-HFGGP---------DAWRLTLASTAV--IGALLFLVRMgtPESPRWLISKGRHAEAEAIIRKVYGPDF 223
Cdd:cd17440   137 IYASAMAWAIIpHYGWSfsmgsayqfHSWRVFVIVCALpcVSSVVALTFM--PESPRFLLEVGKHDEAWMILKQIHDTNM 214

                  ....*...
gi 1188401072 224 GLGNLPEQ 231
Cdd:cd17440   215 RARGQPEK 222
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
31-434 8.94e-08

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 54.03  E-value: 8.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  31 GYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLF 110
Cdd:cd17435    14 GYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 111 ALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLhfGGPDAWRLTLASTAVIGALLFL 190
Cdd:cd17435    94 VGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFA--NVSNGWKYMFGLVIPLAALQAI 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 191 VRMGTPESPRWLISKGrHAEAEAIIrkvygpdfGLgnlpeqaeskNLSFfnllhsgygkrmaFVAIFWTCSVIpvfavyA 270
Cdd:cd17435   172 AMYFLPPSPRFLVMKD-NMRARLLI--------GL----------TLVF-------------FVQITGQPNIL------F 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 271 FAPKVLDALHL-SGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLqsfLWSGLALLLLGLLRDGPSMIILLMFGAy 349
Cdd:cd17435   214 YASTVLKSVGFqSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLC---IGSSVMAVSLVTMGLWLSLASLLVYVA- 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 350 ALFIGGAQVLQLVYpNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLAPET 429
Cdd:cd17435   290 AFSIGLGPMPWLVL-SEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGLPWVCFIYTAMSLASLVFVIMFVPET 368

                  ....*
gi 1188401072 430 NARSL 434
Cdd:cd17435   369 KGCSL 373
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
76-425 1.04e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 53.73  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17320    57 LSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAP 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALLHFGGpdaWRLTLASTAVIGALLF-LVRMGTPESprwLISKGRHAEAEAIIRkvygpdfglgnlpeqaes 234
Cdd:cd17320   137 ALAPLLGGLLLLFFG---WRAIFVFLALLGLLLLlLVLLFLPET---LPEEKRKPLLSSLLR------------------ 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 235 knlSFFNLLHSGYGKRMAFVAIFwtcSVIPVFAVYAFAPKVL-DALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGR 313
Cdd:cd17320   193 ---AYKRVLKNRRFLGYALALGL---SFAGLFAYLAAAPFIYiEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGP 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 314 RKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLqlvYPN------EIFPtEIRAGAVGVGTSLSRIG 387
Cdd:cd17320   267 RRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLI---FPNatslalEPFP-HVAGTASALLGFLQFLI 342
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1188401072 388 AAVGTWLVpaslQSLGIGTTMYIAAAITFVGLVVSWWL 425
Cdd:cd17320   343 GALAGALV----GLLPNGTALPMGLLILVLGLLALLLL 376
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
48-425 1.62e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.98  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  48 LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVA 127
Cdd:cd17489    26 LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAA 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 128 TAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLFLVRMGTPESPRWLISKGR 207
Cdd:cd17489   106 ATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 208 HAEAEAIIRKVYGPDFGLGnlpeqaesknlsffnLLHSGYGKRMAFVAIFwtcsvipvfavyafapkvLDALHLSGKWGS 287
Cdd:cd17489   186 RAFRRLVEKKVLPPALILF---------------LASIAYGAISTFLPLY------------------AAERGISNAGLF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 288 YGSVAITLLFVVgcVIATRLVNTLGRRKLLLQSFLwSGLALLLLGLLRDGPSMIIL------LMFGAyALFIGGAQVLQL 361
Cdd:cd17489   233 FTVYAIALLLSR--PFSGKLSDRKGPKTVIIPGLL-LLALGLLLLSFAGSPWMLLLaavlygLGFGL-LFPALQALAVDL 308
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1188401072 362 VypneifPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWL 425
Cdd:cd17489   309 V------PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
76-434 3.80e-07

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 52.14  E-value: 3.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17434    64 LNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGS 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALlhfggPDAWRLTLASTAVIGALLFLVRMgtPESPRWLISKGRHAEAEAIIRKVYGPDFGLGNLPEQAE-- 233
Cdd:cd17434   144 LALYALGLLL-----PWRWLAVAGEVPVVIMILLLCFM--PNSPRFLISKGKDEKALKALAWLRGPNTDYMTEFEQIKdn 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 234 ----SKNLSFFNLLHSGYGKRM---AFVAIFWTCSVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVvgcVIATR 306
Cdd:cd17434   217 irkqSSRLSWAELKTPSYYKPIliaVVMRFLQQLTGITPILVYLEPIFHLTAVILEPKYDAALVGAVRLLSV---AIAAS 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 307 LVNTLGRRKLLLQSflwSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLQLvypNEIFPTEIRAGAVGVGTSLSRI 386
Cdd:cd17434   294 LMDKAGRKILLFTS---AFLMFAANLSMGLIPLIAAMLFIMGYAMGWGPITWLLM---SEILPLKARGVASGLCVVVSWI 367
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1188401072 387 GAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLAPETNARSL 434
Cdd:cd17434   368 TAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTL 415
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
251-433 4.46e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.51  E-value: 4.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 251 MAFVAIFWTCSVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLL 330
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 331 LGLLRDGPSMIILLMFGAyaLFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYI 410
Cdd:COG2814    92 CALAPSLWLLLAARFLQG--LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
                         170       180
                  ....*....|....*....|...
gi 1188401072 411 AAAITFVGLVVSWWLAPETNARS 433
Cdd:COG2814   170 NAVLALLALLLLLRLLPESRPAA 192
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
75-191 9.85e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 50.63  E-value: 9.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  75 ALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAG 154
Cdd:cd17321    53 RLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIG 132
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1188401072 155 AAAAYMLGEALLHFGGpdaWRLTLASTAVIGALLFLV 191
Cdd:cd17321   133 AALGPLLGGLLLELFG---WRWIFLINVPIGLVALLL 166
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
76-426 4.07e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 48.81  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:PRK11551   73 LADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGG 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALlhfGGPDAWRLTLastaVIG-----ALLFLVRMGTPESPRWLISKGRHAEAEAIIRKVYGPdfglgnlpe 230
Cdd:PRK11551  153 ALASVIGVLA---AGDAAWRHIF----YVGgvgplLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALFGE--------- 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 231 qaesknlsffnllhsgyGKRMAFVAIfWT---CSVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRL 307
Cdd:PRK11551  217 -----------------GRATATLLL-WIsyfFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGAL 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 308 VNTLGRRKLLLQSFLWSGLALLLLGLLrdgPSMIILLMFGAYA-LFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRI 386
Cdd:PRK11551  279 MDRLRPRRVVLLIYAGILASLAALAAA---PSFAGMLLAGFAAgLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRL 355
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1188401072 387 GAAVGTwLVPASLQSLGIGTTMYIAAAI--TFVGLVVSWWLA 426
Cdd:PRK11551  356 GSMAGP-LLAGQLLALGRSTVGVIGASIpvILVAALAALLLV 396
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
76-390 8.72e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 47.53  E-value: 8.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGiEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17372    57 VSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLG-GGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGT 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGEALLHFGGpdaWRLTLASTAVIGALLFLVRMGTPESPR--WLIskgrhaeaeaiirkvygpdfglgnlpeqae 233
Cdd:cd17372   136 IFEASLAWLVMPRLG---WRWLLAFSSVPSSLLLVFYRWTPKTTLllWVI------------------------------ 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 234 sknlsFFNLLHSGYGKRMAFVAIFWTCSVIPVFA-VYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLG 312
Cdd:cd17372   183 -----WFGNAFAYYGVVLLTTELNNSHNVCGSKSdSDSGESPTEKQCRNSNDVDYRDVFIATFAEFPGLLISAAMIDRLG 257
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1188401072 313 RRKLLlQSFLWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLqLVYPNEIFPTEIRAGAVGVGTSLSRIGAAV 390
Cdd:cd17372   258 RKASM-ASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVV-YIYTPEVYPTAVRALGVGTGSSVGRIGAIL 333
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
76-220 1.05e-05

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 47.72  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRR--MLY-----FVGPTLFVVCSVAQYWvqsgEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLT 148
Cdd:cd17431    73 FVNRFGRRnsMLYnnllaFAGAALMGLSKLAKSY----EMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQ 148
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1188401072 149 ILWFAGAAAAYMLGEALLhFGGPDAWRLTLASTAVIGALLFLVRMGTPESPRWL-ISKGRHAEAEAIIRKVYG 220
Cdd:cd17431   149 LGIVVGILISQIFGLEFI-LGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEEEAKSVLKKLRG 220
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
33-421 2.48e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 46.41  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  33 VLSIIGIAMM-----KVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGE 107
Cdd:cd17474     9 LLAVLGVSIVdpilpAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 108 MLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALlhfgGPDAWRLTLASTAVIGAL 187
Cdd:cd17474    89 LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL----AAISWRYPFFLLAALIPV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 188 LFLVRMGTPESPrwliskgrhaeaeaiirkvygpdfglgnlPEQAESKNLSFFNLLHSGYGKRMAFVAIFWTCSVIPV-F 266
Cdd:cd17474   165 AFLAILFLLPEP-----------------------------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLyF 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 267 AVYAFAPKVLDAL-HLSGKWGSYGSVAITLLFVVGCVIATRLVNT-LGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILL 344
Cdd:cd17474   216 AFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAI 295
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1188401072 345 MFgaYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVV 421
Cdd:cd17474   296 VL--FGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
47-426 2.48e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.40  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  47 ALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPV 126
Cdd:COG2807    47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 127 ATAFLVEFLPKKnRGPCLATLTILWFAGAAAAYMLGEALLHFGGpdaWRLTLASTAVIGALLFLvrmgtpesPRWLISKG 206
Cdd:COG2807   127 LPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALG---WRGALAVWALLALLALL--------LWLPLLRR 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 207 RHAeaeaiirkvygpdfglgnlPEQAESKNLSFFNLLHSgygKRMAFVAIFWTCSVIPVFAVYAFAPKVLDALHLSGKWG 286
Cdd:COG2807   195 RPA-------------------AAAAAPAAASLRSLWRS---PLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 287 SYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLrdGPSMIILLMFGAYALFIGGAQVLQLVYPNE 366
Cdd:COG2807   253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL--APGSLPWLWAVLLGLGQGGLFPLALTLIGL 330
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1188401072 367 IFPTEIRAGA-VGVGTSLSRIGAAVGTWLVPASLQSLG-IGTTMYIAAAITFVGLVVSWWLA 426
Cdd:COG2807   331 RARTPAEAAAlSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAG 392
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
108-421 2.78e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 46.37  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 108 MLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRG----------PC---LATLTILwfagAAAAYMLGEALLHFGgpdaW 174
Cdd:cd17369   107 LLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGfygsfpqlgaPVgllLATGVFL----LLSALLSDEAFLSWG----W 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 175 RLTLASTAVIGALLFLVRMGTPESP--RWLISKGRHAEAEAI--IRKVYGPDFGlgnlpeqaesknlsffnllhsGYGKR 250
Cdd:cd17369   179 RIPFLLSAVLVAVGLYIRLRLEETPvfRRAKEAGQVVRAPLVevLRRHWRALLL---------------------AIGLR 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 251 MAFVAIFWtcsVIPVFAVyAFAPKVLdalhlsgkwgSYGSVAITLLFVVGCVIAT-------RLVNTLGRRKLLLQSFLW 323
Cdd:cd17369   238 LAENVLFY---LFTTFAL-SYATQTL----------GVDRSTVLLAVLIASVVAAitiplfgWLSDRVGRRPVYLAGALL 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 324 SGLALLLLGLLRD--GPSMIILLMFGAYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAA-----VGTWLVP 396
Cdd:cd17369   304 AALFAFPFFWLLDtgSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGgfaplIATALVA 383
                         330       340
                  ....*....|....*....|....*
gi 1188401072 397 ASLQSLGIGTTMYIAAAITFVGLVV 421
Cdd:cd17369   384 ATGSWWPVALYLAALAVISLVAALF 408
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
48-199 4.97e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.44  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  48 LGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVA 127
Cdd:TIGR00881  25 IGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPC 104
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1188401072 128 TAFLVEFLPKKNRGPCLATLTI-LWFAGAAAAYMLGEALLHFGGpdaWRLTLASTA----VIGALLFLVRMGTPESP 199
Cdd:TIGR00881 105 GRTVTKWFSRSERGTWVSFWNCsHNVGGGLLPPLVLFGIAELYS---WHWVFIVPGiiaiIVSLICFLLLRDSPQSC 178
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
76-191 6.19e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 44.87  E-value: 6.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17323    57 LSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGP 136
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1188401072 156 AAAYMLGEALLHFGGpdaWRLTLASTAVIGALLFLV 191
Cdd:cd17323   137 ALGPIIGGFITQSLG---WRWIFWFLAIISGFCLIL 169
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
31-199 9.74e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.47  E-value: 9.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  31 GYVLSIIGIAMmkvsPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLF 110
Cdd:cd17477    13 GLLLPLLSLRL----EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 111 ALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWfagaAAAYMLGEALLHFGGPDAWRLTLASTAVIGA---L 187
Cdd:cd17477    89 LLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVL----GLGFALGPLLLALVGTAGALPFLIAAVLLLLalvP 164
                         170
                  ....*....|..
gi 1188401072 188 LFLVRMGTPESP 199
Cdd:cd17477   165 LLLTRRAAPEIE 176
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
251-439 1.17e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 251 MAFVAIFWTCSVIPVFAVyaFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLL 330
Cdd:COG2223     9 LATLAFFLAFGVWYLWSV--LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 331 LGLLRDGPSMII---LLMFGAYALFIGGAQVLqlvypNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTT 407
Cdd:COG2223    87 LALAVSYWLLLLlglLLGIGGGGSFAVGIALV-----SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1188401072 408 MYIAAAITFVGLVVSWWLAPETNARSLADASS 439
Cdd:COG2223   162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKA 193
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
76-423 1.48e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.70  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAfLVEFLPKKNRGpclaTLTILWFAGA 155
Cdd:cd17478    54 LADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGAR-LASQAAGGRRG----LAMSIFSVGG 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 156 AAAYMLGE-----ALLHFGGPDAWRLTLASTAVIGALLFLVRMGTPESPRwliSKGRHAEAEAIIRKVYGPdfglgnlpe 230
Cdd:cd17478   129 NLGFALGPliaaaLVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK---KAAAKSSARSTLKGVWRA--------- 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 231 qaesknlsFFNLLHSGYGKRMAFVAIFwtcSVIPVFAVYAFAPKVLDALHLSgkwgsygsvAITLLFVVGCVIATRLVNT 310
Cdd:cd17478   197 --------LLLLLIIVFLRSWVLSSLT---TFLPFYLVQRGYSLVFAGLLLS---------LFLFAGAIGTLIGGPLSDR 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 311 LGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFGayaLFIGGAQVLQLVYPNEIFPtEIRAGAVGVGTSLSRIGAAV 390
Cdd:cd17478   257 FGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAG---FLLFASFPVTVVLAQELLP-GNVGLASGLMMGLSFGLGGI 332
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1188401072 391 GTWLVPASLQSLGIGTTMYIAAAITFVGLVVSW 423
Cdd:cd17478   333 GAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
254-436 1.50e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.95  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 254 VAIFWTCSVIPVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGL 333
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 334 LRDGPSMIILLMFgaYALFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIG--TTMYIA 411
Cdd:cd06174    81 APSFWLLLLGRFL--LGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIA 158
                         170       180
                  ....*....|....*....|....*
gi 1188401072 412 AAITFVGLVVSWWLAPETNARSLAD 436
Cdd:cd06174   159 AALALLAAILLLLVVPDPPESARAK 183
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
75-426 1.63e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.72  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  75 ALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAG 154
Cdd:cd17473    57 WLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLG 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 155 AAAAYMLGEALLHFGgpdaWRLTLASTAVIGALLFLVRMGTPESPRwliSKGRHAEAEAIIRKVYGPdfglgnlpeqaes 234
Cdd:cd17473   137 GVVFLLLGGALAEIG----WRAPFLVYLLALPVLILVLLFLPEPAR---KSKSAASPGAATAAALPW------------- 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 235 knlsffnllhsgygKRMAFVAIFWTCSVIPVFAVYAFAPKVLDALHL-SGKWGSYGSVAITLLFVVGCVIATRLVNTLGR 313
Cdd:cd17473   197 --------------KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 314 RKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLQLVypNEIFPTEIRAGAVGVGTSLSRIGAAVGTW 393
Cdd:cd17473   263 RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA--MSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1188401072 394 LV-PASLQSLGIGTTMYIAAAITFVGLVVSWWLA 426
Cdd:cd17473   341 VLgPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
76-121 1.92e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 43.39  E-value: 1.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVG 121
Cdd:PRK15402   71 LSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
76-209 2.44e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 43.38  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd17328    57 LGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGS 136
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1188401072 156 AAAYMLGEALLHFGGPdaWRLTLASTAVIGALL-FLVRMGTPESPRWLISKGRHA 209
Cdd:cd17328   137 GLGYVVGGLVAQATGG--WRWAFRVTGVLGVLLaILLLLFVREPPRGAAEGGVMA 189
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
24-403 3.80e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  24 GGGSFVDGYVLSIIGIAMMKV-SPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRL----GRRMLYF-VGPTLFVVCS 97
Cdd:COG2211    16 GLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRRPWIlIGAIPLALSF 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  98 VAQYWVQSGE------MLFALRFLNGVAVGIEYPVATAFLVEFLP-KKNRGPCLATLTILWFAGAAAAYMLGEALLHFGG 170
Cdd:COG2211    96 VLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFG 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 171 PDA---WRLTLASTAVIGALLFLV-RMGTPESPRwliskgrhaeaeaiirkvygpdfglgnLPEQAESKNLSFFNLLHSG 246
Cdd:COG2211   176 GDAalgYRLTALIFAVLGLLAFLLtFFGTKERPV---------------------------PEEEKVSLKESLKALLKNR 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 247 YGKRMAFVAIFWTCSVIPVFAVYAFApkVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGL 326
Cdd:COG2211   229 PFLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 327 ALLLLGLLRDGPSMIILLMFGAYALFIGGAQVLQLVY------PNEIFPTEIRAGAV-GVGTSLSRIGAAVGTWLVPASL 399
Cdd:COG2211   307 GLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdYDEWKTGRRREGLYfGIFTFAIKLGQALAGALAGLLL 386

                  ....
gi 1188401072 400 QSLG 403
Cdd:COG2211   387 ALFG 390
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
76-191 5.35e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 42.23  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVAtAFLVEFLPKKNRGPCLATLTILWFAGA 155
Cdd:cd06179    55 LSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGA-AVASELVPNKYRGLVQGVVNLVASPGS 133
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1188401072 156 AAAYMLGEALLHfGGPDAWR---LTLASTAVIGALLFLV 191
Cdd:cd06179   134 ALGPLIAGALVE-ANAAGWRwifYINAIFNALALILLFF 171
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-158 5.85e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.88  E-value: 5.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072   6 SVEDVPLNRFHRLLTVRSGGGSFVDGYVLSIIGIAMMKVspaLGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRML 85
Cdd:COG2814   199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV---LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1188401072  86 YFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAGAAAA 158
Cdd:COG2814   276 LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
270-440 8.34e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.25  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 270 AFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKLLLQSFLWSGLALLLLGLLRDGPSMIILLMFGAy 349
Cdd:pfam07690  18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQG- 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 350 aLFIGGAQVLQLVYPNEIFPTEIRAGAVGVGTSLSRIGAAVGTWLVPASLQSLGIGTTMYIAAAITFVGLVVSWWLAPET 429
Cdd:pfam07690  97 -LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPP 175
                         170
                  ....*....|.
gi 1188401072 430 NARSLADASSL 440
Cdd:pfam07690 176 ESKRPKPAEEA 186
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
76-200 9.25e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 41.42  E-value: 9.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNgvAVGIEYPVAT--AFLVEFLPKKNRGPCLATLTILWFA 153
Cdd:PRK11043   64 LSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQ--AVGVCSAAVIwqALVIDRYPAQKANRVFATIMPLVAL 141
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1188401072 154 GAAAAYMLGEALL-HFGgpdaWRLTLASTAVIGALLFLVRMGTPESPR 200
Cdd:PRK11043  142 SPALAPLLGAWLLnHFG----WQAIFATLFAITLLLILPTLRLKPSKK 185
2_A_01_02 TIGR00880
Multidrug resistance protein;
75-191 1.04e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 39.17  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  75 ALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAG 154
Cdd:TIGR00880  20 LLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALG 99
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1188401072 155 AAAAYMLGEALLHFGGpdaWRLTLASTAVIGALLFLV 191
Cdd:TIGR00880 100 PLLGPPLGGVLAQFLG---WRAPFLFLAILALAAFIL 133
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
48-190 1.36e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  48 LGLTAFWEGLI-AASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPV 126
Cdd:cd17474   229 YGISPIIIGLLfAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPL 308
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1188401072 127 ATAFLVEFLPKKNRGPCLATLTILWFAGAAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLFL 190
Cdd:cd17474   309 LTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
76-190 2.05e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 40.44  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWVQSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLT-ILWFAG 154
Cdd:TIGR00710  63 LSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMpVLALAP 142
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1188401072 155 AAAAYMLGEALLHFGgpdaWRLTLASTAVIGALLFL 190
Cdd:TIGR00710 143 AVAPLLGGYILVWLS----WHAIFAFLSLAGILLSA 174
PRK12307 PRK12307
MFS transporter;
26-423 4.02e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 39.53  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  26 GSFVDGYVLSIIGIAMMKVSPALGLTAFWEGLIAASALIGIFFGGFIGGALTDRLGRRMLYFVGPTLFVVCSVAQYWVQS 105
Cdd:PRK12307   26 GYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASG 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 106 GEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAG-AAAAYMLGEallhFGGPDAWRLTLASTAVI 184
Cdd:PRK12307  106 VIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGnIIAAYFMPS----FAEAYGWRAAFFVGLLP 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 185 GALLFLVRMGTPESPRWLISKGRhaeaeaiirkvygpdfGLGNLPEQAESK-NLSFFNLLHSGYGKRMAFVAIFWTCSVI 263
Cdd:PRK12307  182 VLLVIYIRARAPESKEWEEAKLS----------------GKGKHSQSAWSVfSLSMKGLFNRAQFPLTLCVFIVLFSIFG 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 264 PVFAVYAFAPKVLDALHLSGKWGSYGSVAITLLFVVGCVIATRLVNTLGRRKL----LLQSFLWsglALLLLGLLRDGPS 339
Cdd:PRK12307  246 ANWPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTfsigLLMSFLF---IFPLFRIPQDNYL 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072 340 MIILLMFGAYALFIG-GAQVLQLVYpnEIFPTEIRagavGVGTSL-SRIGAAVGTWlvpASLQSLGIGTTMYIAAAITFV 417
Cdd:PRK12307  323 LLGACLFGLMATNVGvGGLVPKFLY--DYFPLEVR----GLGTGLiYNLAATSGTF---NSMAATWLGITMGLGAALTFI 393

                  ....*.
gi 1188401072 418 glVVSW 423
Cdd:PRK12307  394 --VAFW 397
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
76-189 4.31e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  76 LTDRLGRRMLYFVGPTLFVVCSVAQYWV-QSGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLATLTILWFAG 154
Cdd:cd17477   246 LADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLG 325
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1188401072 155 AAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLF 189
Cdd:cd17477   326 SVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
75-200 6.64e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188401072  75 ALTDRLGRRMLYFVGPTLFVVCSVAQYWVQ-SGEMLFALRFLNGVAVGIEYPVATAFLVEFLPKKNRGPCLA-TLTILWF 152
Cdd:COG2223   263 WLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGlVGAAGGL 342
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1188401072 153 AGAAAAYMLGEALLHFGGPDAWRLTLASTAVIGALLFLVRMGTPESPR 200
Cdd:COG2223   343 GGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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