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Conserved domains on  [gi|1194630761|ref|WP_085962473|]
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MULTISPECIES: IS3-like element ISSen4 family transposase [Enterobacteriaceae]

Protein Classification

transposase family protein( domain architecture ID 1750059)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0006313
PubMed:  11774877

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
8-356 8.60e-110

IS3 family transposase;


:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 325.67  E-value: 8.60e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761   8 EQIISILREA-EAGVPARELCRKHAISDATFYTWRKKY-GGMEVPEVKRLKSL----EEENARLKKLLAEAMLEKEALQV 81
Cdd:NF033516    1 EFKLEAVREVlEGGKSVAEVARELGISPSTLYRWRKKYrGGGEAADAGRLKELltpeEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  82 AlgRKLLTTDQKREAVMLMCDatGLSQRRACRLTGLSLSTCRYEAHRPAA-----DAHLSGRITELALERR-RFGYRRIW 155
Cdd:NF033516   81 A--RKLLRPAVKYALIDALRG--EYSVRRACRVLGVSRSTYYYWRKRPPSrrapdDAELRARIREIFEESRgRYGYRRIT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 156 QLLRREVLHVNHKRVYRLYHLSGLGVKRRR---RRKGLATERLPL--------LRPAAPNLTWSMDFVMDALSTGRrIKC 224
Cdd:NF033516  157 ALLRREGIRVNHKRVYRLMRELGLLARRRRkrrPYTTDSGHVHPVapnllnrqFTATRPNQVWVTDITYIRTAEGW-LYL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 225 LTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFRGYP--ATIRTDQGPEFTCRALDQWAFEHGVELRLIQPGKPTQNG 302
Cdd:NF033516  236 AVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPegLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNA 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1194630761 303 FIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSEFA 356
Cdd:NF033516  316 VAESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
8-356 8.60e-110

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 325.67  E-value: 8.60e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761   8 EQIISILREA-EAGVPARELCRKHAISDATFYTWRKKY-GGMEVPEVKRLKSL----EEENARLKKLLAEAMLEKEALQV 81
Cdd:NF033516    1 EFKLEAVREVlEGGKSVAEVARELGISPSTLYRWRKKYrGGGEAADAGRLKELltpeEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  82 AlgRKLLTTDQKREAVMLMCDatGLSQRRACRLTGLSLSTCRYEAHRPAA-----DAHLSGRITELALERR-RFGYRRIW 155
Cdd:NF033516   81 A--RKLLRPAVKYALIDALRG--EYSVRRACRVLGVSRSTYYYWRKRPPSrrapdDAELRARIREIFEESRgRYGYRRIT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 156 QLLRREVLHVNHKRVYRLYHLSGLGVKRRR---RRKGLATERLPL--------LRPAAPNLTWSMDFVMDALSTGRrIKC 224
Cdd:NF033516  157 ALLRREGIRVNHKRVYRLMRELGLLARRRRkrrPYTTDSGHVHPVapnllnrqFTATRPNQVWVTDITYIRTAEGW-LYL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 225 LTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFRGYP--ATIRTDQGPEFTCRALDQWAFEHGVELRLIQPGKPTQNG 302
Cdd:NF033516  236 AVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPegLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNA 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1194630761 303 FIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSEFA 356
Cdd:NF033516  316 VAESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
58-361 1.81e-71

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 225.42  E-value: 1.81e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  58 LEEENARLKKLLAEAMLEKEALQVALGRKLLTTDQKREAVMLMCDATGLSQRRACRLTglslstCRYEAHRPAADAHLSG 137
Cdd:COG2801     2 LAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRL------RRPRSYRADEDAELLE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 138 RITELALERRRFGYRRIWQLLRREVLHVNHKRVYRLYHLSGLGVKRRRRRKGLATERLP-------LLRPAAPNLTWSMD 210
Cdd:COG2801    76 RIKEIFAESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGgpiapnlLFTATAPNQVWVTD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 211 FVMDALSTGRrIKCLTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFRGY--PATIRTDQGPEFTCRALDQWAFEHGV 288
Cdd:COG2801   156 ITYIPTAEGW-LYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPpkPLILHSDNGSQYTSKAYQELLKKLGI 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1194630761 289 ELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSEFAAGWRK 361
Cdd:COG2801   235 TQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQLAA 307
rve_3 pfam13683
Integrase core domain;
286-352 8.36e-37

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 127.72  E-value: 8.36e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1194630761 286 HGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTP 352
Cdd:pfam13683   1 LGIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
transpos_IS481 NF033577
IS481 family transposase; null
 93-354 2.78e-29

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 114.23  E-value: 2.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  93 KREAVMLMCDATGLSQRRACRLTGLSLSTC-----RYEAH-------RPAADAHLSGRITE------LAL-ERRRFGYRR 153
Cdd:NF033577    1 GRLELVRLVLEDGWSVREAARRFGISRKTVykwlkRYRAGgeeglidRSRRPHRSPRRTSPeteariLALrRELRLGPRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 154 IWQLLRREVLHVNHKRVYRLYHLSGLgvkrrrrrkglatERLPLLRP----------AAPNLTWSMDFV-MDALSTGRRI 222
Cdd:NF033577   81 IAYELERQGPGVSRSTVHRILRRHGL-------------SRLRALDRktgkvkryerAHPGELWHIDIKkLGRIPDVGRL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 223 KCLTCVDDFTKECLT--VTVAFGISGVQVTRildsiALFRGYPATIR---TDQGPEFTCRA--LDQWAFEHGVELRLIQP 295
Cdd:NF033577  148 YLHTAIDDHSRFAYAelYPDETAETAADFLR-----RAFAEHGIPIRrvlTDNGSEFRSRAhgFELALAELGIEHRRTRP 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1194630761 296 GKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSE 354
Cdd:NF033577  223 YHPQTNGKVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTPAE 281
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 128-354 3.18e-15

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 74.90  E-value: 3.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 128 RPAADAHLSGRITEL-ALERRRFGYRRIWQLLRREVLHVNHKRVYRLYHLSGL-----GVKRRRRRKGLATERLPLLR-- 199
Cdd:PHA02517   24 RAQHDDWLKSEILRVyDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLagvlrGKKVRTTISRKAVAAPDRVNrq 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 200 --PAAPNLTWSMDFVMdaLSTGRRIKCLTCVDD-FTKECLTVTVAFGISGVQVTRILDSIALFRGYPAT--IRTDQGPEF 274
Cdd:PHA02517  104 fvATRPNQLWVADFTY--VSTWQGWVYVAFIIDvFARRIVGWRVSSSMDTDFVLDALEQALWARGRPGGliHHSDKGSQY 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 275 TCRALDQWAFEHGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSE 354
Cdd:PHA02517  182 VSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELATLEWVAWYNNRRLHERLGYTPPAE 261
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
8-356 8.60e-110

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 325.67  E-value: 8.60e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761   8 EQIISILREA-EAGVPARELCRKHAISDATFYTWRKKY-GGMEVPEVKRLKSL----EEENARLKKLLAEAMLEKEALQV 81
Cdd:NF033516    1 EFKLEAVREVlEGGKSVAEVARELGISPSTLYRWRKKYrGGGEAADAGRLKELltpeEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  82 AlgRKLLTTDQKREAVMLMCDatGLSQRRACRLTGLSLSTCRYEAHRPAA-----DAHLSGRITELALERR-RFGYRRIW 155
Cdd:NF033516   81 A--RKLLRPAVKYALIDALRG--EYSVRRACRVLGVSRSTYYYWRKRPPSrrapdDAELRARIREIFEESRgRYGYRRIT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 156 QLLRREVLHVNHKRVYRLYHLSGLGVKRRR---RRKGLATERLPL--------LRPAAPNLTWSMDFVMDALSTGRrIKC 224
Cdd:NF033516  157 ALLRREGIRVNHKRVYRLMRELGLLARRRRkrrPYTTDSGHVHPVapnllnrqFTATRPNQVWVTDITYIRTAEGW-LYL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 225 LTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFRGYP--ATIRTDQGPEFTCRALDQWAFEHGVELRLIQPGKPTQNG 302
Cdd:NF033516  236 AVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPegLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNA 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1194630761 303 FIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSEFA 356
Cdd:NF033516  316 VAESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
58-361 1.81e-71

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 225.42  E-value: 1.81e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  58 LEEENARLKKLLAEAMLEKEALQVALGRKLLTTDQKREAVMLMCDATGLSQRRACRLTglslstCRYEAHRPAADAHLSG 137
Cdd:COG2801     2 LAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRL------RRPRSYRADEDAELLE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 138 RITELALERRRFGYRRIWQLLRREVLHVNHKRVYRLYHLSGLGVKRRRRRKGLATERLP-------LLRPAAPNLTWSMD 210
Cdd:COG2801    76 RIKEIFAESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGgpiapnlLFTATAPNQVWVTD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 211 FVMDALSTGRrIKCLTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFRGY--PATIRTDQGPEFTCRALDQWAFEHGV 288
Cdd:COG2801   156 ITYIPTAEGW-LYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPpkPLILHSDNGSQYTSKAYQELLKKLGI 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1194630761 289 ELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSEFAAGWRK 361
Cdd:COG2801   235 TQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQLAA 307
rve_3 pfam13683
Integrase core domain;
286-352 8.36e-37

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 127.72  E-value: 8.36e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1194630761 286 HGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTP 352
Cdd:pfam13683   1 LGIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
transpos_IS481 NF033577
IS481 family transposase; null
 93-354 2.78e-29

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 114.23  E-value: 2.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  93 KREAVMLMCDATGLSQRRACRLTGLSLSTC-----RYEAH-------RPAADAHLSGRITE------LAL-ERRRFGYRR 153
Cdd:NF033577    1 GRLELVRLVLEDGWSVREAARRFGISRKTVykwlkRYRAGgeeglidRSRRPHRSPRRTSPeteariLALrRELRLGPRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 154 IWQLLRREVLHVNHKRVYRLYHLSGLgvkrrrrrkglatERLPLLRP----------AAPNLTWSMDFV-MDALSTGRRI 222
Cdd:NF033577   81 IAYELERQGPGVSRSTVHRILRRHGL-------------SRLRALDRktgkvkryerAHPGELWHIDIKkLGRIPDVGRL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 223 KCLTCVDDFTKECLT--VTVAFGISGVQVTRildsiALFRGYPATIR---TDQGPEFTCRA--LDQWAFEHGVELRLIQP 295
Cdd:NF033577  148 YLHTAIDDHSRFAYAelYPDETAETAADFLR-----RAFAEHGIPIRrvlTDNGSEFRSRAhgFELALAELGIEHRRTRP 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1194630761 296 GKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSE 354
Cdd:NF033577  223 YHPQTNGKVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTPAE 281
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 203-298 1.67e-23

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 1.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 203 PNLTWSMDFVMDALST-GRRIKCLTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFRGY-PATIRTDQGPEFTCRALD 280
Cdd:pfam00665   1 PNQLWQGDFTYIRIPGgGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGvPLIIHSDNGSEYTSKAFR 80

                          90
                  ....*....|....*...
gi 1194630761 281 QWAFEHGVELRLIQPGKP 298
Cdd:pfam00665  81 EFLKDLGIKPSFSRPGNP 98
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 2-70 1.17e-18

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 79.32  E-value: 1.17e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1194630761   2 KKRFSDEQIISILREA-EAGVPARELCRKHAISDATFYTWRKKY-GGMEVPEVK-RLKSLEEENARLKKLLA 70
Cdd:pfam01527   4 RRRFSEEFKLRAVKEVlEPGRTVKEVARRHGVSPNTLYQWRRQYeGGMGASPARpRLTALEEENRRLKRELA 75
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 128-354 3.18e-15

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 74.90  E-value: 3.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 128 RPAADAHLSGRITEL-ALERRRFGYRRIWQLLRREVLHVNHKRVYRLYHLSGL-----GVKRRRRRKGLATERLPLLR-- 199
Cdd:PHA02517   24 RAQHDDWLKSEILRVyDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLagvlrGKKVRTTISRKAVAAPDRVNrq 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 200 --PAAPNLTWSMDFVMdaLSTGRRIKCLTCVDD-FTKECLTVTVAFGISGVQVTRILDSIALFRGYPAT--IRTDQGPEF 274
Cdd:PHA02517  104 fvATRPNQLWVADFTY--VSTWQGWVYVAFIIDvFARRIVGWRVSSSMDTDFVLDALEQALWARGRPGGliHHSDKGSQY 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 275 TCRALDQWAFEHGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSE 354
Cdd:PHA02517  182 VSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELATLEWVAWYNNRRLHERLGYTPPAE 261
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 128-355 4.90e-11

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 62.81  E-value: 4.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 128 RPAADAHLSGRITELALERRRFGYRRIWQLLRRE-----VLHVNHKRVYRLYHLSglgvkrrrrrkGLATERLPLLRPAA 202
Cdd:PRK09409   45 RHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQaeldgMPAINAKRVYRIMRQN-----------ALLLERKPAVPPSK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 203 -----------PNLTWSMDFVMDALSTGRRIKCLTCVDDFTKECLTVTVAFGisGVQVTRILDSI--ALFRGY------- 262
Cdd:PRK09409  114 rahtgrvavkeSNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTG--GFNSETVQDVMlgAVERRFgndlpss 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 263 PATIRTDQGPEFTCRALDQWAFEHGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECR 342
Cdd:PRK09409  192 PVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWH 271

                         250
                  ....*....|...
gi 1194630761 343 PHSTLNYQTPSEF 355
Cdd:PRK09409  272 PHSALGYRSPREY 284
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
3-354 1.10e-10

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 62.21  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761   3 KRFSDEQIISILREAEAGVPARELCRKHAISDATFYTWRKKYGGMEVPEVKRLKSLEEENARLKKLLaeamlekealqva 82
Cdd:COG2826     5 KHLTLEEREEIEALLKAGLSVREIARRLGRSPSTISRELKRNSGRRGYRAEGAQRLAEDRRRRPKRK------------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761  83 lgRKLLTTDQKREAVmlmcdATGLSQrracrltGLSLSTCryeAHRPAADAHLSGRITELALerrrfgYRRIW-QLLRRE 161
Cdd:COG2826    72 --RKLATTPELRAYV-----EEKLRK-------KWSPEQI---AGRLKREDDPGMRVSHETI------YRYIYaGGLRKD 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 162 VL-HVNHKRVYRLYHlsglgvKRRRRRKGLATERLPL-LRPAAPNL-----TWSMDFVMdalstGRRIKC--LTCVDDFT 232
Cdd:COG2826   129 LYrPLRRKRKRRRPR------GRTRKRRGKIPDRRSIsERPAEVEDraepgHWEGDLII-----GKRGKSalLTLVERKS 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 233 KECLTVTVAfGISGVQVTRILdsIALFRGYPATIR----TDQGPEFTCRalDQWAFEHGVELRLIQPGKPTQNGFIESFN 308
Cdd:COG2826   198 RFVILLKLP-DKTAESVADAL--IRLLRKLPAFLRksitTDNGKEFADH--KEIEAALGIKVYFADPYSPWQRGTNENTN 272

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1194630761 309 GRFRDECLNEHWFSDIVHARkiINDWRQDYNEcRPHSTLNYQTPSE 354
Cdd:COG2826   273 GLLRQYFPKGTDFSTVTQEE--LDAIADRLNN-RPRKCLGYKTPAE 315
PRK14702 PRK14702
insertion element IS2 transposase InsD; Provisional
 128-355 1.35e-10

insertion element IS2 transposase InsD; Provisional


Pssm-ID: 237792 [Multi-domain]  Cd Length: 262  Bit Score: 61.29  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 128 RPAADAHLSGRITELALERRRFGYRRIWQLLRRE-----VLHVNHKRVYRLYHLSglgvkrrrrrkGLATERLPLLRPAA 202
Cdd:PRK14702    6 RHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQaeldgMPAINAKRVYRLMRQN-----------ALLLERKPAVPPSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 203 -----------PNLTWSMDFVMDALSTGRRIKCLTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFR-------GYPA 264
Cdd:PRK14702   75 rahtgrvavkeSNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERrfgndlpSSPV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761 265 TIRTDQGPEFTCRALDQWAFEHGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPH 344
Cdd:PRK14702  155 EWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPH 234

                         250
                  ....*....|.
gi 1194630761 345 STLNYQTPSEF 355
Cdd:PRK14702  235 SALGYRSPREY 245
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
2-84 1.96e-09

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 54.16  E-value: 1.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761   2 KKRFSDEQIISILREA-EAGVPARELCRKHAISDATFYTWRKKY---GGMEVPEVKRLKSLEEENARLKKLLAEAMLEKE 77
Cdd:COG2963     5 RRRYSPEFKAEAVRLVlEGGASVAEVARELGISPSTLYRWVRQYregGLGGFPGDGRTTPEQAEIRRLRKELRRLEMEND 84


                  ....*..
gi 1194630761  78 ALQVALG 84
Cdd:COG2963    85 ILKKAAA 91
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 130-179 8.89e-09

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 51.42  E-value: 8.89e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1194630761 130 AADAHLSGRITELALE-RRRFGYRRIWQLLRRE-VLHVNHKRVYRLYHLSGL 179
Cdd:pfam13276   1 ELEDELLEAIREIFEEsRGTYGYRRITAELRREgGIRVNRKRVARLMRELGL 52
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 13-44 1.29e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 36.42  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1194630761  13 ILREAEAGVPARELCRKHAISDATFYTWRKKY 44
Cdd:pfam13518   5 IVLLALEGESIKEAARLFGISRSTVYRWIRRY 36
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 46-87 3.69e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 37.18  E-value: 3.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1194630761  46 GMEVPE---VKRLKSLEEENARLKKLLAEAMLEKEALQVALGRKL 87
Cdd:pfam11221  85 GIGVSEeeqLQRIKELEEELREAEEERQEAVKEKEELLKKLDELI 129
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 2-97 6.88e-03

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 36.32  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194630761   2 KKRFSDEQIISILREAEAGVPARELCRKHAISDATFYTWRKKYGGMEVPEVKrlkslEEENARLKKLLAEAMLEKEALQV 81
Cdd:PRK09413   11 RRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVA-----AGEQVVPASELAAAMKQIKELQR 85

                          90
                  ....*....|....*.
gi 1194630761  82 ALGRKLLTTDQKREAV 97
Cdd:PRK09413   86 LLGKKTMENELLKEAV 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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