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Conserved domains on  [gi|1196865132|ref|WP_086309976|]
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MULTISPECIES: LytTR family DNA-binding domain-containing protein [Enterococcus]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-228 3.67e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 99.12  E-value: 3.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   1 MKKYFIIEDNQFHSEWIIKELVNH-HIENIVQLTSIFQINQLIQLGTIDnhdVFFIDIDLKQsLTGIDVAEQIRKKNAHS 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYpDLEVVGEASNGEEALELLEEHKPD---LVFLDIQMPG-LDGFELARQLRELDPPP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132  80 NIVFFTAYTNFAVDIInrKILPIGYIRK---DRNLSEQIHQVLEQINWKEQQIVNV---DKIFIDQKGGSLVLYPREILY 153
Cdd:COG3279    77 PIIFTTAYDEYALEAF--EVNAVDYLLKpidEERLAKALEKAKERLEAKAAAEASPeekDRIFVKSGGKLVKIPLDDILY 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1196865132 154 IESikgLKNQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLKSYCINLSQLQKID-SAHYVLEFFNGDSLLVGRK 228
Cdd:COG3279   155 IEA---EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEkNFNGEVVLKNGEEIPVSRR 227
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-228 3.67e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 99.12  E-value: 3.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   1 MKKYFIIEDNQFHSEWIIKELVNH-HIENIVQLTSIFQINQLIQLGTIDnhdVFFIDIDLKQsLTGIDVAEQIRKKNAHS 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYpDLEVVGEASNGEEALELLEEHKPD---LVFLDIQMPG-LDGFELARQLRELDPPP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132  80 NIVFFTAYTNFAVDIInrKILPIGYIRK---DRNLSEQIHQVLEQINWKEQQIVNV---DKIFIDQKGGSLVLYPREILY 153
Cdd:COG3279    77 PIIFTTAYDEYALEAF--EVNAVDYLLKpidEERLAKALEKAKERLEAKAAAEASPeekDRIFVKSGGKLVKIPLDDILY 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1196865132 154 IESikgLKNQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLKSYCINLSQLQKID-SAHYVLEFFNGDSLLVGRK 228
Cdd:COG3279   155 IEA---EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEkNFNGEVVLKNGEEIPVSRR 227
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 5-128 6.20e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 53.01  E-value: 6.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   5 FIIEDN---QFHSEWIIKE-LVNHHIENIVQLTSifQINQLIQLGTID-NHDVFFIDIDLK-QSLTGIDVAEQIRKKNAH 78
Cdd:cd17533     4 FILEDDkiqRVRLEEIIENiLKIENIEYVIELTG--KTEELLEKIKERgKNGIYFLDIDIKmEEKNGLEVAQKIRKYDPY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1196865132  79 SNIVFFTAYTNFAVDIINRKILPIGYIRKDRNLSEQIHQVLEQINWKEQQ 128
Cdd:cd17533    82 AIIIFVTTHSEFAPLTFEYKVAALDFILKPLKLEEFKKRIEECIKYAQKN 131
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 141-236 5.49e-07

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 46.41  E-value: 5.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132  141 GGSLVLYPREILYIESikgLKNQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLKSYCINLSQLQKID---SAHYVLEF 217
Cdd:smart00850   1 GRIVLIPLDDILYIEA---EGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEpwfNGTYLLIL 77

                           90
                   ....*....|....*....
gi 1196865132  218 FNGDSLLVGRKIFEKTKER 236
Cdd:smart00850  78 KNGEEVPVSRRYLKELKER 96
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 141-228 5.23e-06

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 43.73  E-value: 5.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132 141 GGSLVLYPREILYIESIKGlknQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLKSYCINLSQLQKIDSA---HYVLEF 217
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDK---YVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDfngTYELTL 77

                          90
                  ....*....|.
gi 1196865132 218 FNGDSLLVGRK 228
Cdd:pfam04397  78 KNGEKIPVSRR 88
PRK14084 PRK14084
DNA-binding response regulator;
47-227 5.98e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 37.04  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132  47 IDNHDVFFIDIDLKQSlTGIDVAEQIRKKNAHSNIVFFTAYTNFAVDIInrKILPIGYIRKDRNLsEQIHQVLEQINWKE 126
Cdd:PRK14084   44 INQYDIIFLDINLMDE-SGIELAAKIQKMKEPPAIIFATAHDQFAVKAF--ELNATDYILKPFEQ-KRIEQAVNKVRATK 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132 127 QQIVNVDK-IFIDQKGGSLVLYPREI------LYIESIKGL---KNQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLK 196
Cdd:PRK14084  120 AKDDNNASaIANDMSANFDQSLPIEIddkihmLNQQDIIAIgvhNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHR 199

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1196865132 197 SYCINLSQLQKID---SAHYVLEFFNGDSLLVGR 227
Cdd:PRK14084  200 SYIINKKHIKEVEqwfNYTYQVILTNGVKMQVSR 233
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-228 3.67e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 99.12  E-value: 3.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   1 MKKYFIIEDNQFHSEWIIKELVNH-HIENIVQLTSIFQINQLIQLGTIDnhdVFFIDIDLKQsLTGIDVAEQIRKKNAHS 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYpDLEVVGEASNGEEALELLEEHKPD---LVFLDIQMPG-LDGFELARQLRELDPPP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132  80 NIVFFTAYTNFAVDIInrKILPIGYIRK---DRNLSEQIHQVLEQINWKEQQIVNV---DKIFIDQKGGSLVLYPREILY 153
Cdd:COG3279    77 PIIFTTAYDEYALEAF--EVNAVDYLLKpidEERLAKALEKAKERLEAKAAAEASPeekDRIFVKSGGKLVKIPLDDILY 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1196865132 154 IESikgLKNQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLKSYCINLSQLQKID-SAHYVLEFFNGDSLLVGRK 228
Cdd:COG3279   155 IEA---EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEkNFNGEVVLKNGEEIPVSRR 227
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 5-128 6.20e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 53.01  E-value: 6.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   5 FIIEDN---QFHSEWIIKE-LVNHHIENIVQLTSifQINQLIQLGTID-NHDVFFIDIDLK-QSLTGIDVAEQIRKKNAH 78
Cdd:cd17533     4 FILEDDkiqRVRLEEIIENiLKIENIEYVIELTG--KTEELLEKIKERgKNGIYFLDIDIKmEEKNGLEVAQKIRKYDPY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1196865132  79 SNIVFFTAYTNFAVDIINRKILPIGYIRKDRNLSEQIHQVLEQINWKEQQ 128
Cdd:cd17533    82 AIIIFVTTHSEFAPLTFEYKVAALDFILKPLKLEEFKKRIEECIKYAQKN 131
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 141-236 5.49e-07

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 46.41  E-value: 5.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132  141 GGSLVLYPREILYIESikgLKNQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLKSYCINLSQLQKID---SAHYVLEF 217
Cdd:smart00850   1 GRIVLIPLDDILYIEA---EGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEpwfNGTYLLIL 77

                           90
                   ....*....|....*....
gi 1196865132  218 FNGDSLLVGRKIFEKTKER 236
Cdd:smart00850  78 KNGEEVPVSRRYLKELKER 96
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 51-107 1.66e-06

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 45.86  E-value: 1.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1196865132  51 DVFFIDIDLKQSLTGIDVAEQIRKKnahSNI--VFFTAYTNfaVDIINR--KILPIGYIRK 107
Cdd:cd17534    47 DLILMDINLKGDMDGIEAAREIREK---FDIpvIFLTAYSD--EETLERakETNPYGYLVK 102
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 141-228 5.23e-06

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 43.73  E-value: 5.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132 141 GGSLVLYPREILYIESIKGlknQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLKSYCINLSQLQKIDSA---HYVLEF 217
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDK---YVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDfngTYELTL 77

                          90
                  ....*....|.
gi 1196865132 218 FNGDSLLVGRK 228
Cdd:pfam04397  78 KNGEKIPVSRR 88
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 5-93 1.28e-05

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 43.30  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   5 FIIEDnqfhsEWIIKELVNHHIENIVQLTSIFQI-NQLIQLGTIDNH--DVFFIDIDLKqSLTGIDVAEQIRKKNAHSNI 81
Cdd:cd17532     2 LIVDD-----EPLAREELRYLLEEHPDIEIVGEAeNGEEALEAIEELkpDVVFLDIQMP-GLDGLELAKKLSKLAKPPLI 75

                          90
                  ....*....|..
gi 1196865132  82 VFFTAYTNFAVD 93
Cdd:cd17532    76 VFVTAYDEYAVE 87
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-107 5.45e-05

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 41.06  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   6 IIEDNQFHSEWIIKELVNHHIEnIVQLTSIFQinqLIQLGTIDNHDVFFIDIDLKQsLTGIDVAEQIRKKNAHSNIVFFT 85
Cdd:cd00156     2 IVDDDPAIRELLKSLLEREGYE-VDTAADGEE---ALELLREERPDLVLLDLMMPG-MDGLELLRKLRELPPDIPVIVLT 76

                          90       100
                  ....*....|....*....|..
gi 1196865132  86 AYTNFAVDIINRKILPIGYIRK 107
Cdd:cd00156    77 AKADEEDAVRALELGADDYLVK 98
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-89 6.28e-04

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 38.29  E-value: 6.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   5 FIIEDNQFHSEwIIKELVNHHIENIVQLTSIFQINQLIQLGTIDnhdVFFIDIDLkQSLTGIDVAEQIRKKNAHSNIVFF 84
Cdd:pfam00072   2 LIVDDDPLIRE-LLRQLLEKEGYVVAEADDGKEALELLKEERPD---LILLDINM-PGMDGLELLKRIRRRDPTTPVIIL 76


                  ....*
gi 1196865132  85 TAYTN 89
Cdd:pfam00072  77 TAHGD 81
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-92 6.41e-04

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 38.80  E-value: 6.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132   1 MKKYFIIEDNQFHSEwIIKELVNHH--IENIVQLTSIfqiNQLIQLGTIDNHDVFFIDIDLKQsLTGIDVAEQIRKKNAH 78
Cdd:COG4565     3 MIRVLIVEDDPMVAE-LLRRYLERLpgFEVVGVASSG---EEALALLAEHRPDLILLDIYLPD-GDGLELLRELRARGPD 77

                          90
                  ....*....|....
gi 1196865132  79 SNIVFFTAYTNFAV 92
Cdd:COG4565    78 VDVIVITAARDPET 91
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 51-120 1.10e-03

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 37.88  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1196865132  51 DVFFIDIDLKQsLTGIDVAEQIRKKNAHSNIVFFTAYTN--FAVDIINRKILpiGYIRKD---RNLSEQIHQVLE 120
Cdd:cd17535    46 DVVLMDLSMPG-MDGIEALRRLRRRYPDLKVIVLTAHDDpeYVLRALKAGAA--GYLLKDsspEELIEAIRAVAA 117
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 51-121 5.22e-03

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 35.98  E-value: 5.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1196865132  51 DVFFIDIDLKQsLTGIDVAEQIRKKNAHSN--IVFFTAYTNFAVDIINRKILPIGYIRK---DRNLSEQIHQVLEQ 121
Cdd:COG0784    51 DLILLDINMPG-MDGLELLRRIRALPRLPDipIIALTAYADEEDRERALEAGADDYLTKpvdPEELLEALRRLLAR 125
PRK14084 PRK14084
DNA-binding response regulator;
47-227 5.98e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 37.04  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132  47 IDNHDVFFIDIDLKQSlTGIDVAEQIRKKNAHSNIVFFTAYTNFAVDIInrKILPIGYIRKDRNLsEQIHQVLEQINWKE 126
Cdd:PRK14084   44 INQYDIIFLDINLMDE-SGIELAAKIQKMKEPPAIIFATAHDQFAVKAF--ELNATDYILKPFEQ-KRIEQAVNKVRATK 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196865132 127 QQIVNVDK-IFIDQKGGSLVLYPREI------LYIESIKGL---KNQVMVKTTTEDKLVSTSLKQLKIELEKYTYFLLLK 196
Cdd:PRK14084  120 AKDDNNASaIANDMSANFDQSLPIEIddkihmLNQQDIIAIgvhNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHR 199

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1196865132 197 SYCINLSQLQKID---SAHYVLEFFNGDSLLVGR 227
Cdd:PRK14084  200 SYIINKKHIKEVEqwfNYTYQVILTNGVKMQVSR 233
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 51-121 7.23e-03

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 37.25  E-value: 7.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1196865132  51 DVFFIDIDLKQsLTGIDVAEQIRKKNAHSNIVFFTAYTNF--AVDIINRKIlpIGYIRK--DRN-LSEQIHQVLEQ 121
Cdd:COG2204    48 DLVLLDLRMPG-MDGLELLRELRALDPDLPVILLTGYGDVetAVEAIKAGA--FDYLTKpfDLEeLLAAVERALER 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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