|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
14-361 |
4.24e-122 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 358.01 E-value: 4.24e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 14 LCIDCKSFYSSVECVERGLnPLTTMLVVLSGSDrpgGLVLAASPAAKKeLGISNFTRKYELPDH---KDLICVPPRMNLY 90
Cdd:cd01700 1 ALVDCNSFYASCERVFRPL-LLGRPLVVLSNND---GCVIARSPEAKA-LGIKMGSPYFKVPDLlerHGVAVFSSNYALY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 91 IETNIKIVNIIRRYVsdDDIHVYSIDELFVRFDKVKNlYGNCRtkQFAKGLMQRILEETGIYTTVGIGDNMLLAKLALDN 170
Cdd:cd01700 76 GDMSRRIMSILERFS--PDVEVYSIDESFLDLTGSLR-FGDLE--ELARKIRRRILQETGIPVTVGIGPTKTLAKLANDL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 171 AGKKNPDM-IAEWRYEDVPSTVWKIKSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMGAIGLQLHAHANGID 249
Cdd:cd01700 151 AKKKNPYGgVVDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGID 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 250 RSEIDkKYKVLEKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYShgellpGFSRQMKVP-- 327
Cdd:cd01700 231 CLPLE-EYPPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTS------GFSRQPKYYsa 303
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1196943218 328 ------ATSNTKQITSYLLQLFEEHYT-GYAVRHVGVSCSK 361
Cdd:cd01700 304 tntlpyPTNDTREIVKAALRLLYAIYRpGYAYRKAGVMLSD 344
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
14-423 |
1.46e-99 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 302.69 E-value: 1.46e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 14 LCIDCKSFYSSVEcveRGLNP-LTTMLVVLSGS-DRPGGLVLAASPAAKKElGISNFTRKYE----LPDhkdLICVPPRM 87
Cdd:PRK03103 6 LLVDMQSFYASVE---KAANPeLKGRPVIVSGDpERRSGVVLAACPLAKAY-GVKTAERLWEaqqkCPD---LVVVKPRM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 88 NLYIETNIKIVNIIRRYVsdDDIHVYSIDELFVRFDKVKNLYGNcrTKQFAKGLMQRILEETGIYTTVGIGDNMLLAKLA 167
Cdd:PRK03103 79 QRYIDVSLQITRILEDFT--DLVEPFSIDEQFLDVTGSQKLFGS--PLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 168 LDNAGKKNPDMIAEWRYEDVPSTVWK--IKSLtdfWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMGAIGLQLHAHA 245
Cdd:PRK03103 155 CDNFAKKNPDGLFTLDKEDVPADLWPlpVRKL---FGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 246 NGIDRSEIDKKYKVLEKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSHGELLPGFSRQMK 325
Cdd:PRK03103 232 NGIDYSPVTPHSLDRQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGFSRQMT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 326 VPATSN-TKQITSYLLQLFEEHYTGYAVRHVGVSCSKLVYQTSLQLDLFSDPEKtiqQEKLDFLCDEIRNRYGFKALIHA 404
Cdd:PRK03103 312 LPEPTNlAMEVYEAACKLFHRHWDGKPVRRVGVTLSNLVSDDVWQLSLFGDRER---KRSLGYVMDDIKNRFGPTAILRA 388
|
410
....*....|....*....
gi 1196943218 405 NSLLPGATAVSRSTKVGGH 423
Cdd:PRK03103 389 SSLTEAGQAFERAAKIGGH 407
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
13-360 |
8.60e-73 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 231.57 E-value: 8.60e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 13 YLCIDCKSFYSSVECVE----RGLnPLttmlVVLSGSDRpgGLVLAASPAAKKeLGISNFTRKYE----LPDhkdLICVP 84
Cdd:COG0389 3 ILHVDMDAFYASVEQRDrpelRGK-PV----AVGGDNNR--GVVAAASYEARA-FGVRSGMPLFQarrlCPD---LVVLP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 85 PRMNLYIETNIKIVNIIRRYVsdDDIHVYSIDELFVRFDKVKNLYGNCRtkQFAKGLMQRILEETGIYTTVGIGDNMLLA 164
Cdd:COG0389 72 PDFELYRDVSRRVMAILERYT--PLVEPLSIDEAFLDVTGSARLFGSAE--AIARRIRRRIRRETGLTVSVGIAPNKFLA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 165 KLAldnAGKKNPDMIAEWRYEDVPSTVWKIkSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMGAIGLQLHAH 244
Cdd:COG0389 148 KIA---SDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 245 ANGIDRSEIDKKYKvlEKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSHGELlpgFSRQM 324
Cdd:COG0389 224 ARGIDPRPVEPRRP--RKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRT---TTRSR 298
|
330 340 350
....*....|....*....|....*....|....*...
gi 1196943218 325 KVP-ATSNTKQITSYLLQLFEEHYT-GYAVRHVGVSCS 360
Cdd:COG0389 299 TLPePTDDTAELLRAARELLERIYRpGRPVRLLGVRLS 336
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
14-362 |
4.22e-58 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 193.51 E-value: 4.22e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 14 LCIDCKSFYSSVECVE----RGLnPLttmlVVLSGSDRpgGLVLAASPAAKKeLGI----SNFTRKYELPDhkdLICVPP 85
Cdd:cd03586 1 IHIDMDAFYASVEQRDnpelKGK-PV----AVGGSSDR--GVVSTASYEARK-FGVrsamPIFQAKKLCPN---LIFVPP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 86 RMNLYIETNIKIVNIIRRYvsDDDIHVYSIDELFVRFDKVKNLYGNcrTKQFAKGLMQRILEETGIYTTVGIGDNMLLAK 165
Cdd:cd03586 70 RFDKYREVSRQIMEILREY--TPLVEPLSIDEAYLDVTDYVRLFGS--ATEIAKEIRARIREETGLTASAGIAPNKFLAK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 166 LAldnAGKKNPDMIAEWRYEDVPSTVWKIKsLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMGAIGLQLHAHA 245
Cdd:cd03586 146 IA---SDLNKPNGLTVIPPEDVEEFLAPLP-VRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 246 NGIDRSEIDKKYKVleKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSHGELLpgfSRQMK 325
Cdd:cd03586 222 RGIDNRPVEPDRER--KSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTR---TRSRT 296
|
330 340 350
....*....|....*....|....*....|....*...
gi 1196943218 326 VPATSNTKQ-ITSYLLQLFEEHYTGYAVRHVGVSCSKL 362
Cdd:cd03586 297 LPEPTDDAEdIYELALELLEELLDGRPIRLLGVRLSGL 334
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
16-401 |
3.26e-51 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 177.53 E-value: 3.26e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 16 IDCKSFYSSVECVErglNP-LTTMLVVLSGS--DRPGgLVLAASPAAKkELGISN----FTRKYELPDhkdLICVPPRMN 88
Cdd:PRK01810 10 VDMNSFFASVEIAY---DPsLQGKPLAVAGNekERKG-IIVTCSYEAR-AYGIRTtmplWEAKRLCPQ---LIVRRPNFD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 89 LYIETNIKIVNIIRRYVsdDDIHVYSIDELFVrfDKVKNLYGNcRTKQFAKGLMQRILEETGIYTTVGIGDNMLLAKLAL 168
Cdd:PRK01810 82 RYREASRQMFQILSEFT--PLVQPVSIDEGYL--DITDCYALG-SPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 169 DnagKKNPDMIAEWRYEDVPSTVWKIkSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMGAIGLQLHAHANGI 248
Cdd:PRK01810 157 D---MKKPLGITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 249 DRSEIDKKYKVLEKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSHGELLPGfSRQMKVPa 328
Cdd:PRK01810 233 DDRPVDPEAIYQFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITR-SKTLKNP- 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1196943218 329 TSNTKQITSYLLQLFEEHYTGYAVRHVGVSCSKLVYQTSL--QLDLFSdPEKTIQQEKLDFLCDEIRNRYGFKAL 401
Cdd:PRK01810 311 IWEKRDIFQAASRLFKQHWNGDPVRLLGVTATDLEWKTEAvkQLDLFS-FEEDAKEEPLLAVIDQINDKYGMPLL 384
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
14-358 |
3.00e-37 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 138.65 E-value: 3.00e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 14 LCIDCKSFYSSVECVERGL---NPLttmlVVLSGSDRPGGLVlAASPAAKKeLGISNFTRKYE----LPDhkdLICVPPR 86
Cdd:cd00424 1 LHIDFDNFFASVEQLARPElkgRPV----VVVPFNSDSTCVI-ACSYEARK-YGVKRGMPVREarkmCPN---LILVPAR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 87 MNLYIETNIKIVNIIRRYVsdDDIHVYSIDELFVRFDKVKNLYGncRTKQFAKGLMQRILEETGIYT-TVGIGDNMLLAK 165
Cdd:cd00424 72 LDLYRRLSERLLSELEEVA--PLVEVASIDELFLDLTGSARLLG--LGSEVALRIKRHIAEQLGGITaSIGIASNKLLAK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 166 LAldnAGKKNPDMIAEWRYEDVPSTVWKIKsLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAA-MGAIGLQLHAH 244
Cdd:cd00424 148 LA---AKYAKPDGLTILDPEDLPGFLSKLP-LTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALwGGVSGERLWYA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 245 ANGIDRSEIDKKYKVleKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSHGE---LLPGFS 321
Cdd:cd00424 224 LRGIDDEPLSPPRPR--KSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRwsgHADIPS 301
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1196943218 322 RQMKVPATSNTKQITSYLLQLFE---EHYTGYAVRHVGVS 358
Cdd:cd00424 302 RSAPRPISTEDGELLHALDKLWRallDDKGPRRLRRLGVR 341
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
16-169 |
4.68e-34 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 124.22 E-value: 4.68e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 16 IDCKSFYSSVEcveRGLNP-LTTMLVVLSGSDRpGGLVLAASPAAKKeLGISNFTRKYELPD-HKDLICVPPRMNLYIET 93
Cdd:pfam00817 1 IDMDAFFASVE---LLRDPeLKGKPVAVGGGNG-RGIVAAASYEARK-YGVRSGMPVFEAKKlCPNLIVVPPDLELYRRA 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1196943218 94 NIKIVNIIRRYvSDDDIHVYSIDELFVRFDKVKNLYGNcrTKQFAKGLMQRILEETGIYTTVGIGDNMLLAKLALD 169
Cdd:pfam00817 76 SRKIFEILRRF-STPKVEQASIDEAFLDLTGLEKLFGA--EEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
17-407 |
7.03e-25 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 105.45 E-value: 7.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 17 DCKSFYSSVEcvERgLNPlttmlvVLSGsdRP----GGLVLAASPAAKKeLGISNftrkyELPDHK------DLICVPPR 86
Cdd:PRK03858 10 DLDSFYASVE--QR-DDP------ALRG--RPvivgGGVVLAASYEAKA-YGVRT-----AMGGRQarrlcpQAVVVPPR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 87 MNLYIEtnikivniirryVSDDDIHVY----------SIDELFVRFDKVKNLYGNCRtkQFAKGLMQRILEETGIYTTVG 156
Cdd:PRK03858 73 MSAYSR------------ASKAVFEVFrdttplveglSIDEAFLDVGGLRRISGTPV--QIAARLRRRVREEVGLPITVG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 157 IGDNMLLAKLAldnAGKKNPDMIAEwryedVPSTvwkikSLTDF---------WGIGHRTAKNLWKRGITTVEELANTPP 227
Cdd:PRK03858 139 VARTKFLAKVA---SQVAKPDGLLV-----VPPD-----RELAFlhplpvrrlWGVGPVTAAKLRAHGITTVGDVAELPE 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 228 SRLKAAMG-AIGLQLHAHANGIDRSEIDKKYKvlEKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIA 306
Cdd:PRK03858 206 SALVSLLGpAAGRHLHALAHNRDPRRVETGRR--RRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 307 LSIGYshgellPGFSRQMK---VP-ATSNTKQITSYLLQLFEEHYTGYAVRH---VGVSCSKLVYQTSLQLDL-FSDPEK 378
Cdd:PRK03858 284 LRLRF------DDFTRATRshtLPrPTASTATLLAAARDLVAAAAPLIAERGltlVGFAVSNLDDDGAQQLELpFGLRRP 357
|
410 420
....*....|....*....|....*....
gi 1196943218 379 TiqqEKLDFLCDEIRNRYGFKALIHANSL 407
Cdd:PRK03858 358 G---SALDAALDAVRDRFGNAAVTRAVLL 383
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
262-363 |
1.18e-22 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 91.85 E-value: 1.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 262 KSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSHGEllpGFSRQMKVP-ATSNTKQITSYLL 340
Cdd:pfam11799 2 KSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFR---TITRSVTLPsPTDDTDEIYRAAL 78
|
90 100
....*....|....*....|...
gi 1196943218 341 QLFEEHYTGYAVRHVGVSCSKLV 363
Cdd:pfam11799 79 RLLRRLYRGRPVRLLGVSLSNLV 101
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
83-383 |
6.09e-21 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 94.62 E-value: 6.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 83 VPPRMNLYIETNIKIVNIIRRYVSDddIHVYSIDELFVrfdKVKNLYGNC--RTKQFAKGLMQRILEETGIYTTVGIGDN 160
Cdd:PRK03348 75 LPPRFVVYRAASRRVFDTLRELSPV--VEQLSFDEAFV---EPAELAGASaeEVEAFAERLRARVREETGLPASVGAGSG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 161 MLLAKLALDNAgkkNPD---MIAEWRYEDV--PSTVWKIksltdfWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMG 235
Cdd:PRK03348 150 KQIAKIASGLA---KPDgirVVPPGEERELlaPLPVRRL------WGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLG 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 236 -AIGLQLHAHANGID------RSEidkkykvlEKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALS 308
Cdd:PRK03348 221 aTVGPALHRLARGIDdrpvaeRAE--------AKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVK 292
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1196943218 309 IGYSHGELLpgfSRQMKVP-ATSNTKQITSYLLQLFEEHYTGYAVRHVGVSCSKLVyqTSLQLDLFSDPEKTIQQE 383
Cdd:PRK03348 293 LRKSDFSTL---TRSATLPyATDDAAVLAATARRLLLDPDEIGPIRLVGVGFSGLS--DVRQESLFPELDLARETA 363
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
136-291 |
7.45e-19 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 87.00 E-value: 7.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 136 QFAKGLMQRILEETGIYTTVGIGDNMLLAKLALDNAgkkNPDMIaeWRYEDvpSTVWKI---KSLTDFWGIGHRTAKNLW 212
Cdd:PRK03352 122 ALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFA---KPAGV--FRLTD--ANWMAVmgdRPTDALWGVGPKTAKRLA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 213 KRGITTVEELANTPPSRLKAAMG-AIGLQLHAHANGIDRSEIDKKYKVlEKSISNSQILMKDYTDKKEVMIIIREMADLV 291
Cdd:PRK03352 195 ALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVSAEPWV-PRSRSREVTFPQDLTDRAEVESAVRELARRV 273
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
17-373 |
1.51e-18 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 86.33 E-value: 1.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 17 DCksFYSSVEcvERGlNP-LTTMLVVLSGSDRPGGLVLAASPAAkkelgisnftRKY------------EL-PDhkdLIC 82
Cdd:PRK02406 2 DC--FYAAVE--MRD-NPeLRGKPVAVGGSPGRRGVISTCNYEA----------RKFgvrsamptaqalKLcPD---LIF 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 83 VPPRMNLYIETNIKIVNIIRRYVsdDDIHVYSIDE--LFVRFDKvknLYGNCRTKqFAKGLMQRILEETGIYTTVGIGDN 160
Cdd:PRK02406 64 VPGRFDVYKEVSRQIREIFRRYT--DLIEPLSLDEayLDVTDNK---LCIGSATL-IAQEIRQDIFEELGLTASAGVAPN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 161 MLLAKLALDnagKKNPDMIAEWRYEDVPSTVWKIkSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMGAIGLQ 240
Cdd:PRK02406 138 KFLAKIASD---WNKPNGLFVITPEEVDAFLATL-PVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRR 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 241 LHAHANGIDRSEIdkKYKVLEKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNE--SIALSIGYSHGELLp 318
Cdd:PRK02406 214 LYERARGIDERPV--KPDRERKSVGVERTFAEDLYDLEACLAELPRLAEKLERRLERAKPDKRikTVGVKLKFADFQQT- 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1196943218 319 gfSRQMKVPATSNTKQITSyLLQLFEEHYTGYAVRHVGVSCSKLVYQTSLQLDLF 373
Cdd:PRK02406 291 --TKEHTADPLDKADLIEL-LAQALLRRLGGRGVRLLGVGVTLLEPQLERQLLLD 342
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
16-313 |
3.35e-18 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 85.15 E-value: 3.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 16 IDCKSFYSSVECVErglNP-LTTMLVVLSG-SDRpgGLVLAASPAAKKeLGISN----FTRKYELPDHkdlICVPPRMNL 89
Cdd:PRK14133 8 VDMDAFFASVEQMD---NPkLKGKPVIVGGiSER--GVVSTCSYEARK-YGVHSampvFMAKKRCPHG---IFLPVRHER 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 90 YIETNIKIVNIIrrYVSDDDIHVYSIDELFVRFDKVKNlygncRTKQFAKGLMQRILEETGIYTTVGIGDNMLLAKLALD 169
Cdd:PRK14133 79 YKEVSKNIFKIL--YEVTPIVEPVSIDEAYLDITNIKE-----EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASD 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 170 nagKKNPDMIAEWRYEDVPStVWKIKSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMGAIGLQLHAHANGID 249
Cdd:PRK14133 152 ---WNKPDGIKIITEDMIPD-ILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGID 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1196943218 250 RSEIDKKYKVleKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSH 313
Cdd:PRK14133 228 YREVEVSRER--KSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSD 289
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
16-403 |
4.46e-18 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 85.75 E-value: 4.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 16 IDCKSFYSSVEcvERGlNP-LTTMLVVLSGSDRpgGLVLAASPAAkkelgisnftRKY----ELPDHK------DLICVP 84
Cdd:PRK02794 41 IDCDAFYASVE--KRD-NPeLRDKPVIIGGGKR--GVVSTACYIA----------RIHgvrsAMPMFKalklcpDAVVIK 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 85 PRMNLYIETNIKIVNIIRRYVSDddIHVYSIDELFVRFDKVKNLYGNCRTKQFAKgLMQRILEETGIYTTVGIGDNMLLA 164
Cdd:PRK02794 106 PDMEKYVRVGREVRAMMQALTPL--VEPLSIDEAFLDLSGTERLHGAPPAVVLAR-FARRVEREIGITVSVGLSYNKFLA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 165 KLA--LDN-------AGKKNPDMIAEwryedvpstvwkiKSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMG 235
Cdd:PRK02794 183 KIAsdLDKprgfsviGRAEALAFLAP-------------KPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 236 AIGLQLHAHANGIDRSEIDKKYKVleKSISNSQILMKDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSIGYSHGE 315
Cdd:PRK02794 250 SMGLRLWRLARGIDDRKVSPDREA--KSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFR 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 316 LLpgfSRQMKVPA-TSNTKQITSYLLQLFEEHYTGYAVRHVGVSCSKLVYQT-SLQLDLFsDP--------EKTIqqekl 385
Cdd:PRK02794 328 LR---TRRRTLEDpTQLADRIFRTARELLEKETDGTAFRLIGIGVSDLSPADeADPPDLL-DPqatrraaaERAI----- 398
|
410
....*....|....*...
gi 1196943218 386 dflcDEIRNRYGFKALIH 403
Cdd:PRK02794 399 ----DALRAKFGAAAVET 412
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
14-235 |
8.29e-17 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 80.99 E-value: 8.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 14 LCIDCKSFYSSVECVergLNPL----TTMLVVLSGSDRPGGLVLAASPAAKKeLGISN---FTRKYELPdhKDLICVPPR 86
Cdd:PRK01216 4 LFVDFDYFFAQVEEV---LNPSlkgkPVVVCVYSGRFEDSGAVATANYEARK-LGIKAgmpIVEAKKIL--PNAVYLPMR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 87 MNLYIETNIKIVNIIRRYvsDDDIHVYSIDELFVRF-DKVKNlygNCRTKQFAKGLMQRILEETGIYTTVGIGDNMLLAK 165
Cdd:PRK01216 78 KEVYQQVSNRIMKLLREY--SEKIEIASIDEAYLDIsDKVKN---YQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAK 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 166 LALDNAgkkNPDMIAEWRYEDVPSTVWKIKsLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMG 235
Cdd:PRK01216 153 IAADMA---KPNGIKVIDDEEVKRFINELD-IADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIG 218
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
79-362 |
1.67e-15 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 77.74 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 79 DLICVPPRMNLYIETNIKIVNIIRRYVsdDDIHVYSIDELFVRFDKVKNlYGNCRTKQFAKGLMQRILEETGIYTTVGIG 158
Cdd:cd01701 113 QLVTLPYDFEAYEEVSLTFYEILASYT--DNIEAVSCDEALIDITSLLE-ETYELPEELAEAIRNEIRETTGCSASVGIG 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 159 DNMLLAKLALDNAgkkNPDMIAEWRYEDVPSTVWKIKsLTDFWGIGHRTAKNLWKRGITT--VEELANTPPSRLKAAMGA 236
Cdd:cd01701 190 PNILLARLATRKA---KPDGQYHLSAEKVEEFLSQLK-VGDLPGVGSSLAEKLVKLFGDTcgGLELRSKTKEKLQKVLGP 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 237 I-GLQLHAHANGIDRSEIDkkYKVLEKSIS---NSQIlmkDYTDKKEVMIIIREMADLVGSRLRKEHAQNESIALSI--- 309
Cdd:cd01701 266 KtGEKLYDYCRGIDDRPVT--GEKERKSVSaeiNYGI---RFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITLKLmkr 340
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1196943218 310 ------------GysHGELLpGFSRQMKVP-ATSNTKQITSYLLQLF-------EEhytgyaVRHVGVSCSKL 362
Cdd:cd01701 341 apgapieppkymG--HGICD-SFSKSSTLGvATDDSGVIGTEAKKLFrdlsippEE------LRGVGIQVTKL 404
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
14-227 |
1.56e-13 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 71.72 E-value: 1.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 14 LCiDCKSFYSSVECVERGlNPLTTMLVVLSGSDrpgGLVLAASPAAKK---ELGISNFTRKYELPDHKdLICVPPRMNLY 90
Cdd:PRK03609 4 LC-DVNSFYASCETVFRP-DLRGKPVVVLSNND---GCVIARSAEAKAlgiKMGDPWFKQKDLFRRCG-VVCFSSNYELY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 91 IETNIKIVNIIRRYVSDddIHVYSIDELFVRFDKVKNlygnCRT-KQFAKGLMQRILEETGIYTTVGIGDNMLLAKLAlD 169
Cdd:PRK03609 78 ADMSNRVMSTLEELSPR--VEIYSIDEAFCDLTGVRN----CRDlTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLA-N 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1196943218 170 NAGKknpdmiaEW--RYEDV-----PSTVWKIKSL---TDFWGIGHRTAKNLWKRGITTVEELANTPP 227
Cdd:PRK03609 151 HAAK-------KWqrQTGGVvdlsnLERQRKLLSLqpvEEVWGVGRRISKKLNAMGIKTALDLADTNI 211
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
50-345 |
9.95e-09 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 56.55 E-value: 9.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 50 GLVLAASPAAKKElgiSNFTRKYELPD---HK-DLicvpprmNLYIETNIKIVNIIRRYVsdDDIHVYSIDELFVRFdkv 125
Cdd:cd01702 60 DLILAHVATYKKG---EDEADYHENPSparHKvSL-------DPYRRASRKILNILKRFG--DVVEKASIDEAYLDL--- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 126 knlygncrTKQFAKGLMQRILEETGIYTTVGIGDNMLLAKLAldnAGKKNPDMIAEWRYEDVPSTVWKiKSLTDFWGIGH 205
Cdd:cd01702 125 --------GSRIVEEIRQQVYDELGYTCSAGIAHNKMLAKLA---SGMNKPNAQTILRNDAVASFLSS-LPITSIRGLGG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 206 R---TAKNLWkrGITTVEELANTPPSRL---KAAMGAIGLQLHAHANGIDRSEIdkKYKVLEKSI-SNSQILMKDYTDKK 278
Cdd:cd01702 193 KlgeEIIDLL--GLPTEGDVAGFRSSESdlqEHFGEKLGEWLYNLLRGIDHEPV--KPRPLPKSMgSSKNFPGKTALSTE 268
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1196943218 279 EVMIIIREMADLVGSRLRKEHAQNESIA--LSIGYSHGELLPGFSRQMKVPATsNTKQITSYLLQLFEE 345
Cdd:cd01702 269 DVQHWLLVLASELNSRLEDDRYENNRRPktLVLSLRQRGDGVRRSRSCALPRY-DAQKIVKDAFKLIKA 336
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
90-345 |
1.55e-05 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 46.69 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 90 YIETNIKIVNIIRRYVSDDDIHVYSIDELFVRFDKVKNLYGNcrtkQFAKGLMQRILEETGIYTTVGIGDNMLLAKLaLD 169
Cdd:cd01703 72 FRDMSKKVYRLLRSYSWNDRVERLGFDENFMDVTEMRLLVAS----HIAYEMRERIENELGLTCCAGIASNKLLAKL-VG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 170 NAGKKNPDMIAEWRYEDVPSTVWKIKSLTDFWGIGHRTAKNLWKRGITTVEELANTPPS-RLKAAMGA------------ 236
Cdd:cd01703 147 SVNKPNQQTTLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSNRnRQTVGAAPsllelllmvkef 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 237 ---IGLQLHAHANGIDRSEidkkykVLEKSISNSQILMKD---YTDKKEVMIIIREMADLVGSRLRKEH----------- 299
Cdd:cd01703 227 gegIGQRIWKLLFGRDTSP------VKPASDFPQQISIEDsykKCSLEEIREARNKIEELLASLLERMKqdlqevkagdg 300
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1196943218 300 AQNESIALSI--------GY---SHGELLPGFSRQMKVPATSNT-KQITSYLLQLFEE 345
Cdd:cd01703 301 RRPHTLRLTLrrytstkkHYnreSKQAPIPSHVFQKLTGGNEIAaRPIEKILMRLFRE 358
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
11-224 |
4.81e-05 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 45.39 E-value: 4.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 11 GDYLCIDCKSFYSSVEcVERGLNPLTTMLVVLSGSdrpgglVLAASPAAKKELGISNFTRKY-ELPDHKDLICVPPRMNL 89
Cdd:PTZ00205 133 GTYIHLDMDMFYAAVE-IKKHPEYAAIPLAIGTMT------MLQTANYVARGRGIRQGMPGFlALKICPNLLILPPDFDA 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 90 YIETNikivNIIRRYVS--DDDIHVYSIDELFVRFDK-VKNLYGNCRTKQFAKGLMQRILEETGIYTTVGIGDNMLLAKL 166
Cdd:PTZ00205 206 YNEES----NTVRRIVAeyDPNYISFGLDELTLEVSAyIERFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKI 281
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 167 AlDNAGKKNP--DMIAEWRyEDVPSTVWKIkSLTDFWGIGHRTAKNLWKRGITTVEELAN 224
Cdd:PTZ00205 282 A-SNINKPNGqhDLNLHTR-GDVMTYVRDL-GLRSVPGVGKVTEALLKGLGITTLSDIYN 338
|
|
| DUF4332 |
pfam14229 |
Domain of unknown function (DUF4332); This family of proteins is functionally uncharacterized. ... |
142-244 |
5.62e-05 |
|
Domain of unknown function (DUF4332); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 134 and 356 amino acids in length. This domain contains helix-hairpin-helix motifs.
Pssm-ID: 464111 Cd Length: 122 Bit Score: 42.25 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196943218 142 MQRILEETGIYTTVGigdnmlLAKLALDNAGKKNpdmIAEWRYEDVpSTVWKIKSLTDFW---GIGHRTAKNLWKRGITT 218
Cdd:pfam14229 7 EAEKLKAAGIKTTDD------LLELGDTPIGRKA---LAAKTGISE-RNLLRWANRADLAripGVGGEYAELLEAAGVDT 76
|
90 100
....*....|....*....|....*.
gi 1196943218 219 VEELANTPPSRLKAAMGAIGLQLHAH 244
Cdd:pfam14229 77 VAELARRNPANLHQKLGRLNRSLRLV 102
|
|
| NT_POLXc |
cd00141 |
Nucleotidyltransferase (NT) domain of family X DNA Polymerases; X family polymerases fill in ... |
185-262 |
1.29e-04 |
|
Nucleotidyltransferase (NT) domain of family X DNA Polymerases; X family polymerases fill in short gaps during DNA repair. They are relatively inaccurate enzymes and play roles in base excision repair, in non-homologous end joining (NHEJ) which acts mainly to repair damage due to ionizing radiation, and in V(D)J recombination. This family includes eukaryotic Pol beta, Pol lambda, Pol mu, and terminal deoxyribonucleotidyl transferase (TdT). Pol beta and Pol lambda are primarily DNA template-dependent polymerases. TdT is a DNA template-independent polymerase. Pol mu has both template dependent and template independent activities. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These three carboxylate residues are fairly well conserved in this family.
Pssm-ID: 143386 [Multi-domain] Cd Length: 307 Bit Score: 43.72 E-value: 1.29e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1196943218 185 EDVPSTvwkIKSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLkAAMGAIGLQLHAHANG-IDRSEIDKKYKVLEK 262
Cdd:cd00141 78 EDVPPG---LLLLLRVPGVGPKTARKLYELGIRTLEDLRKAAGAKL-EQNILIGLEYYEDFQQrIPREEALAIAEIIKE 152
|
|
| DNA_pol_lambd_f |
pfam10391 |
Fingers domain of DNA polymerase lambda; DNA polymerases catalyze the addition of dNMPs onto ... |
197-244 |
1.35e-04 |
|
Fingers domain of DNA polymerase lambda; DNA polymerases catalyze the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone.
Pssm-ID: 463069 [Multi-domain] Cd Length: 51 Bit Score: 39.36 E-value: 1.35e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1196943218 197 LTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKAAMgAIGLQLHAH 244
Cdd:pfam10391 3 FTGIYGVGPTTARKWYAQGYRTLDDLREKKTAKLTRQQ-QIGLKYYDD 49
|
|
| POLXc |
smart00483 |
DNA polymerase X family; includes vertebrate polymerase beta and terminal ... |
193-240 |
3.41e-03 |
|
DNA polymerase X family; includes vertebrate polymerase beta and terminal deoxynucleotidyltransferases
Pssm-ID: 214688 Cd Length: 334 Bit Score: 39.27 E-value: 3.41e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1196943218 193 KIKSLTDFWGIGHRTAKNLWKRGITTVEELANTPPSRLKaAMGAIGLQ 240
Cdd:smart00483 87 SLKLFTNVFGVGPKTAAKWYRKGIRTLEELKKNKELKLT-KQQKAGLK 133
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
202-235 |
4.78e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 35.16 E-value: 4.78e-03
10 20 30
....*....|....*....|....*....|....
gi 1196943218 202 GIGHRTAKNLWKRGITTVEELANTPPSRLKAAMG 235
Cdd:pfam14520 9 GIGPKTALALLSAGIGTVEDLAEADVDELAEIPG 42
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
184-216 |
8.78e-03 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 33.52 E-value: 8.78e-03
10 20 30
....*....|....*....|....*....|...
gi 1196943218 184 YEDVPSTVWKIKsLTDFWGIGHRTAKNLWKRGI 216
Cdd:pfam11798 1 PDDVPEFLWPLP-ISKIPGIGKKLAEKLKALGI 32
|
|
| |
