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Conserved domains on  [gi|1196997752|ref|WP_086414998|]
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MULTISPECIES: 2-oxoacid:acceptor oxidoreductase family protein [Eggerthella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POR super family cl00546
Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large ...
 1-175 3.26e-55

Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyzes the final step in the fermentation of carbohydrates in anaerobic microorganizms. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited.


The actual alignment was detected with superfamily member TIGR02175:

Pssm-ID: 444968 [Multi-domain]  Cd Length: 177  Bit Score: 179.47  E-value: 3.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLG 80
Cdd:TIGR02175   1 MIEIRFHGRGGQGAVTASQLLAEAAFLE-GKYAQAFPEFGAERRGAPVRAFLRISDRPIRVHSQIYEPDYVVVLDPTLLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 EGWETE-LKPGGVVLVNSVRMFDD----ERIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIRQYMPAK 155
Cdd:TIGR02175  80 TVNVTAgLKEDGILIVNTKKDPEElrkeLKVYTVDATKIALVVLGRPIVNTPMLGAFAKVTGLVSLESLEKAIEESFPGK 159

                         170       180
                  ....*....|....*....|
gi 1196997752 156 LHAKNIaivDAAREAMGEVQ 175
Cdd:TIGR02175 160 LAEANA---KAVERAYEEVK 176
PRK14028 super family cl31653
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 2-373 2.51e-40

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


The actual alignment was detected with superfamily member PRK14028:

Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 144.75  E-value: 2.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   2 IEILWHGRGGQGAFTAARLLgAAASLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLGE 81
Cdd:PRK14028    3 IETVWLGRGGQGIVTATYII-ANAAVIDGFYAIANPEFGAERRGAPVKAFLTISKNPIEDQEPVKTPDVAVIFDDKLIDP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  82 GWET--ELKPGGVVLVNSVRM---------FDDERIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIRQ 150
Cdd:PRK14028   82 MRFAidAVKPGGYVILNTGKQpeearklvgRDDVYIVVLDAIGIARKHLKLDVPNGPLAGAFSKVMGFPSLESIRTAFET 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 151 YMpAKLHAKNIAIVDAAREAMGEVQTEREveGAHAAPaESAPSLTACGGSAQDDVVvsprpasripALRSADLDPADFAH 230
Cdd:PRK14028  162 QL-GKAVEENFAATKEAYEVAVVIPPEKV--DASAKP-KGIISTTSAFLTGPYELV----------GWQEVNKAGAVFPG 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 231 STCFdagYLTvknAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKvpsACRptepadaaaspgtrsrdDAEGSRaevspe 310
Cdd:PRK14028  228 SSFP---YLT---GGWRIDKPVIDHSKCIMCRKCWLYCPDDAIIE---AWR-----------------EAEGPR------ 275

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1196997752 311 gtscGARFASAIpaisgtgetlagslgepacafapVAIDLDFCKGCGICAKACKFGSITMILE 373
Cdd:PRK14028  276 ----GRKFRMKM-----------------------IDFDYQYCKGCGVCAEVCPTGAIQMVRE 311
 
Name Accession Description Interval E-value
PorC_KorC TIGR02175
2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; A number ...
 1-175 3.26e-55

2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins (H. pylori) used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes the gamma subunit. In Pyrococcus furious, enzymes active on pyruvate and 2-ketoisovalerate share a common gamma subunit.


Pssm-ID: 274014 [Multi-domain]  Cd Length: 177  Bit Score: 179.47  E-value: 3.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLG 80
Cdd:TIGR02175   1 MIEIRFHGRGGQGAVTASQLLAEAAFLE-GKYAQAFPEFGAERRGAPVRAFLRISDRPIRVHSQIYEPDYVVVLDPTLLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 EGWETE-LKPGGVVLVNSVRMFDD----ERIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIRQYMPAK 155
Cdd:TIGR02175  80 TVNVTAgLKEDGILIVNTKKDPEElrkeLKVYTVDATKIALVVLGRPIVNTPMLGAFAKVTGLVSLESLEKAIEESFPGK 159

                         170       180
                  ....*....|....*....|
gi 1196997752 156 LHAKNIaivDAAREAMGEVQ 175
Cdd:TIGR02175 160 LAEANA---KAVERAYEEVK 176
PRK08534 PRK08534
pyruvate ferredoxin oxidoreductase subunit gamma; Reviewed
 1-174 6.59e-54

pyruvate ferredoxin oxidoreductase subunit gamma; Reviewed


Pssm-ID: 181460 [Multi-domain]  Cd Length: 181  Bit Score: 176.00  E-value: 6.59e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLgAAASLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLG 80
Cdd:PRK08534    1 MIEIRFHGRGGQGAVTAAEIL-AKAAFEDGKFSQAFPFFGVERRGAPVMAFTRIDDKPIRLRSQIYEPDYVIVQDPTLLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 -----EGweteLKPGGVVLVNSVRMFDDE------RIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIR 149
Cdd:PRK08534   80 svdvtSG----LKKDGIIIINTTKDPEDLkydtkaKVYTIDATKIALDVLGVPIVNTTMLGAFAGATGEVSLESLKKAIL 155

                         170       180
                  ....*....|....*....|....*
gi 1196997752 150 QYMPAKLHAKNIAIVDAAREAMGEV 174
Cdd:PRK08534  156 ERFPGKLGEKNAEAVEKAYNLMKEE 180
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 2-373 2.51e-40

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 144.75  E-value: 2.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   2 IEILWHGRGGQGAFTAARLLgAAASLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLGE 81
Cdd:PRK14028    3 IETVWLGRGGQGIVTATYII-ANAAVIDGFYAIANPEFGAERRGAPVKAFLTISKNPIEDQEPVKTPDVAVIFDDKLIDP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  82 GWET--ELKPGGVVLVNSVRM---------FDDERIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIRQ 150
Cdd:PRK14028   82 MRFAidAVKPGGYVILNTGKQpeearklvgRDDVYIVVLDAIGIARKHLKLDVPNGPLAGAFSKVMGFPSLESIRTAFET 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 151 YMpAKLHAKNIAIVDAAREAMGEVQTEREveGAHAAPaESAPSLTACGGSAQDDVVvsprpasripALRSADLDPADFAH 230
Cdd:PRK14028  162 QL-GKAVEENFAATKEAYEVAVVIPPEKV--DASAKP-KGIISTTSAFLTGPYELV----------GWQEVNKAGAVFPG 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 231 STCFdagYLTvknAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKvpsACRptepadaaaspgtrsrdDAEGSRaevspe 310
Cdd:PRK14028  228 SSFP---YLT---GGWRIDKPVIDHSKCIMCRKCWLYCPDDAIIE---AWR-----------------EAEGPR------ 275

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1196997752 311 gtscGARFASAIpaisgtgetlagslgepacafapVAIDLDFCKGCGICAKACKFGSITMILE 373
Cdd:PRK14028  276 ----GRKFRMKM-----------------------IDFDYQYCKGCGVCAEVCPTGAIQMVRE 311
PorG COG1014
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma ...
 1-360 3.11e-38

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440638 [Multi-domain]  Cd Length: 424  Bit Score: 142.14  E-value: 3.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSaVAKADYVIYLDDTLLg 80
Cdd:COG1014     4 DLEIRIAGVGGQGVVTAGKILAKAAMRE-GYYVQGYPSYGSEQRGGPVVSHVRISDEPIRSPL-IDEADVLIALDPEEL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 EGWETELKPGGVVLVNSVRMFD-------------DERIAALDADGISAAVLGRPI-PNTVFLGALSALCDrVSVENVQE 146
Cdd:COG1014    81 DRVLDGLKPGGVLIVNSSLVPPevwrlpqealerkDIRVYVIDATKIAKELLGNARvANTVMLGALAALLG-LPLEALEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 147 AIRQYM---PAKLHAKNIAIVDAAREAMGEVQTEREVEGAHAAPAESAPSLTACGGSAQDDVVVSPRPASRIPALRSADL 223
Cdd:COG1014   160 AIEETFgkkGEKVVELNLKAFEAGYEAAKEVFALAAAPAPLVLLAGNAAAALGAAAGGAAFAAAYPITPSTSLIEAAAAA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 224 DPADFAHSTCFDAGYLTVKNAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKVPSACRPTEPADAAASPGTRSRDDAEGS 303
Cdd:COG1014   240 AAKVGGVVAEEEAAAAAAAAAAAAAAAGAAAAAAGGGGGAALATEGLGLAGMTETPVVAVAAPRPGPGTGTPTEEEQGLL 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1196997752 304 RAevspeGTSCGARFASAIPAISGTGETLAGSLGEPACAFAPVAIDLDFCKGCGICA 360
Cdd:COG1014   320 LL-----AAGGGGGEAPALALAPDTEEELLFAAAAAFALAEYAQALLLLLLLQLLVL 371
POR pfam01558
Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large ...
 10-169 1.52e-31

Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyzes the final step in the fermentation of carbohydrates in anaerobic microorganizms. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited.


Pssm-ID: 426323 [Multi-domain]  Cd Length: 172  Bit Score: 117.40  E-value: 1.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  10 GGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLGEgWETELKP 89
Cdd:pfam01558   1 GGQGVVTAGKILAKAAARA-GYYVQATPEYGSEIRGGPVVSHVRISDEPIVPAIPVGEADLLVALDPETLDR-HLDGLKP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  90 GGVVLVNS------------VRMFDDERIAALDADGISAAVLG-RPIPNTVFLGALSALCDrVSVENVQEAIRQYMP--A 154
Cdd:pfam01558  79 GGIIIYNSsevppellekdlPAYPRLARVYGVPATEIAKEAGGnSRAANTVMLGALAALLG-LPLEALEEAIKKRFPgkA 157

                         170
                  ....*....|....*
gi 1196997752 155 KLHAKNIAIVDAARE 169
Cdd:pfam01558 158 KVIELNLKAFRAGYE 172
PorD_KorD TIGR02179
2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number ...
 238-373 3.11e-12

2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of delta subunits, representing mostly pyruvate, 2-ketoisovalerate, and 2-oxoglutarate specific enzymes. The delta subunit is the smallest and resembles ferredoxins.


Pssm-ID: 131234 [Multi-domain]  Cd Length: 78  Bit Score: 61.58  E-value: 3.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 238 YLTVKNAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKVpsacrptepadaaaspgtrsrddaEGSRAEvspegtscgar 317
Cdd:TIGR02179   7 SVANKTGDWRVFKPVVDKEKCIKCKNCWLYCPEGAIQED------------------------EGGFVG----------- 51

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1196997752 318 fasaipaisgtgetlagslgepacafapvaIDLDFCKGCGICAKACKFGSITMILE 373
Cdd:TIGR02179  52 ------------------------------IDYDYCKGCGICANVCPVKAIEMVRE 77
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 345-375 6.45e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 39.30  E-value: 6.45e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1196997752 345 PVAIDLDFCKGCGICAKACKFGSITMILESE 375
Cdd:cd10549    34 GPEIDEDKCVFCGACVEVCPTGAIELTPEGK 64
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 346-369 3.94e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 34.53  E-value: 3.94e-03
                          10        20
                  ....*....|....*....|....
gi 1196997752 346 VAIDLDFCKGCGICAKACKFGSIT 369
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGAIT 24
 
Name Accession Description Interval E-value
PorC_KorC TIGR02175
2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; A number ...
 1-175 3.26e-55

2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins (H. pylori) used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes the gamma subunit. In Pyrococcus furious, enzymes active on pyruvate and 2-ketoisovalerate share a common gamma subunit.


Pssm-ID: 274014 [Multi-domain]  Cd Length: 177  Bit Score: 179.47  E-value: 3.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLG 80
Cdd:TIGR02175   1 MIEIRFHGRGGQGAVTASQLLAEAAFLE-GKYAQAFPEFGAERRGAPVRAFLRISDRPIRVHSQIYEPDYVVVLDPTLLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 EGWETE-LKPGGVVLVNSVRMFDD----ERIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIRQYMPAK 155
Cdd:TIGR02175  80 TVNVTAgLKEDGILIVNTKKDPEElrkeLKVYTVDATKIALVVLGRPIVNTPMLGAFAKVTGLVSLESLEKAIEESFPGK 159

                         170       180
                  ....*....|....*....|
gi 1196997752 156 LHAKNIaivDAAREAMGEVQ 175
Cdd:TIGR02175 160 LAEANA---KAVERAYEEVK 176
PRK08534 PRK08534
pyruvate ferredoxin oxidoreductase subunit gamma; Reviewed
 1-174 6.59e-54

pyruvate ferredoxin oxidoreductase subunit gamma; Reviewed


Pssm-ID: 181460 [Multi-domain]  Cd Length: 181  Bit Score: 176.00  E-value: 6.59e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLgAAASLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLG 80
Cdd:PRK08534    1 MIEIRFHGRGGQGAVTAAEIL-AKAAFEDGKFSQAFPFFGVERRGAPVMAFTRIDDKPIRLRSQIYEPDYVIVQDPTLLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 -----EGweteLKPGGVVLVNSVRMFDDE------RIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIR 149
Cdd:PRK08534   80 svdvtSG----LKKDGIIIINTTKDPEDLkydtkaKVYTIDATKIALDVLGVPIVNTTMLGAFAGATGEVSLESLKKAIL 155

                         170       180
                  ....*....|....*....|....*
gi 1196997752 150 QYMPAKLHAKNIAIVDAAREAMGEV 174
Cdd:PRK08534  156 ERFPGKLGEKNAEAVEKAYNLMKEE 180
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 2-373 2.51e-40

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 144.75  E-value: 2.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   2 IEILWHGRGGQGAFTAARLLgAAASLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLGE 81
Cdd:PRK14028    3 IETVWLGRGGQGIVTATYII-ANAAVIDGFYAIANPEFGAERRGAPVKAFLTISKNPIEDQEPVKTPDVAVIFDDKLIDP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  82 GWET--ELKPGGVVLVNSVRM---------FDDERIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIRQ 150
Cdd:PRK14028   82 MRFAidAVKPGGYVILNTGKQpeearklvgRDDVYIVVLDAIGIARKHLKLDVPNGPLAGAFSKVMGFPSLESIRTAFET 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 151 YMpAKLHAKNIAIVDAAREAMGEVQTEREveGAHAAPaESAPSLTACGGSAQDDVVvsprpasripALRSADLDPADFAH 230
Cdd:PRK14028  162 QL-GKAVEENFAATKEAYEVAVVIPPEKV--DASAKP-KGIISTTSAFLTGPYELV----------GWQEVNKAGAVFPG 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 231 STCFdagYLTvknAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKvpsACRptepadaaaspgtrsrdDAEGSRaevspe 310
Cdd:PRK14028  228 SSFP---YLT---GGWRIDKPVIDHSKCIMCRKCWLYCPDDAIIE---AWR-----------------EAEGPR------ 275

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1196997752 311 gtscGARFASAIpaisgtgetlagslgepacafapVAIDLDFCKGCGICAKACKFGSITMILE 373
Cdd:PRK14028  276 ----GRKFRMKM-----------------------IDFDYQYCKGCGVCAEVCPTGAIQMVRE 311
PRK14029 PRK14029
pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional
 1-175 6.05e-40

pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional


Pssm-ID: 172523 [Multi-domain]  Cd Length: 185  Bit Score: 140.16  E-value: 6.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLG 80
Cdd:PRK14029    1 MIEIRFHGRGGQGAVTAANILAEAAFLE-GKYVQAFPFFGVERRGAPVTAFTRIDEKPIRIKTQIYEPDVVVVLDPSLLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 EGWETE-LKPGGVVLVNSVRMFDD---------ERIAALDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIRQ 150
Cdd:PRK14029   80 TVDVTAgLKDGGIVIVNTEKSKEEvleklkkkpKKLALVDATTIALEILGLPITNTAILGAVAKATGLVKIESVEEAIKD 159

                         170       180
                  ....*....|....*....|....*
gi 1196997752 151 YMPAKLHAKNiaiVDAAREAMGEVQ 175
Cdd:PRK14029  160 TFSGELGEKN---AKAAREAFEKTV 181
PorG COG1014
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma ...
 1-360 3.11e-38

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440638 [Multi-domain]  Cd Length: 424  Bit Score: 142.14  E-value: 3.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSaVAKADYVIYLDDTLLg 80
Cdd:COG1014     4 DLEIRIAGVGGQGVVTAGKILAKAAMRE-GYYVQGYPSYGSEQRGGPVVSHVRISDEPIRSPL-IDEADVLIALDPEEL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 EGWETELKPGGVVLVNSVRMFD-------------DERIAALDADGISAAVLGRPI-PNTVFLGALSALCDrVSVENVQE 146
Cdd:COG1014    81 DRVLDGLKPGGVLIVNSSLVPPevwrlpqealerkDIRVYVIDATKIAKELLGNARvANTVMLGALAALLG-LPLEALEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 147 AIRQYM---PAKLHAKNIAIVDAAREAMGEVQTEREVEGAHAAPAESAPSLTACGGSAQDDVVVSPRPASRIPALRSADL 223
Cdd:COG1014   160 AIEETFgkkGEKVVELNLKAFEAGYEAAKEVFALAAAPAPLVLLAGNAAAALGAAAGGAAFAAAYPITPSTSLIEAAAAA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 224 DPADFAHSTCFDAGYLTVKNAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKVPSACRPTEPADAAASPGTRSRDDAEGS 303
Cdd:COG1014   240 AAKVGGVVAEEEAAAAAAAAAAAAAAAGAAAAAAGGGGGAALATEGLGLAGMTETPVVAVAAPRPGPGTGTPTEEEQGLL 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1196997752 304 RAevspeGTSCGARFASAIPAISGTGETLAGSLGEPACAFAPVAIDLDFCKGCGICA 360
Cdd:COG1014   320 LL-----AAGGGGGEAPALALAPDTEEELLFAAAAAFALAEYAQALLLLLLLQLLVL 371
POR pfam01558
Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large ...
 10-169 1.52e-31

Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyzes the final step in the fermentation of carbohydrates in anaerobic microorganizms. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited.


Pssm-ID: 426323 [Multi-domain]  Cd Length: 172  Bit Score: 117.40  E-value: 1.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  10 GGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLGEgWETELKP 89
Cdd:pfam01558   1 GGQGVVTAGKILAKAAARA-GYYVQATPEYGSEIRGGPVVSHVRISDEPIVPAIPVGEADLLVALDPETLDR-HLDGLKP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  90 GGVVLVNS------------VRMFDDERIAALDADGISAAVLG-RPIPNTVFLGALSALCDrVSVENVQEAIRQYMP--A 154
Cdd:pfam01558  79 GGIIIYNSsevppellekdlPAYPRLARVYGVPATEIAKEAGGnSRAANTVMLGALAALLG-LPLEALEEAIKKRFPgkA 157

                         170
                  ....*....|....*
gi 1196997752 155 KLHAKNIAIVDAARE 169
Cdd:pfam01558 158 KVIELNLKAFRAGYE 172
PRK05844 PRK05844
pyruvate flavodoxin oxidoreductase subunit gamma; Validated
 1-171 2.44e-24

pyruvate flavodoxin oxidoreductase subunit gamma; Validated


Pssm-ID: 180284 [Multi-domain]  Cd Length: 186  Bit Score: 98.69  E-value: 2.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   1 MIEILWHGRGGQGAFTAARLLGAAASlDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLDDTLLG 80
Cdd:PRK05844    1 MLEIRWHSRAGQGAVTGAKGLADVIA-KTGKEVQAFAFYGSAKRGAAMTAYNRIDDEPILNHEKFMQPDYVLVIDPGLVF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  81 EGWETELKPGGVVLVNSVRMFDDERIAA-----------LDADGISAAVLGRPIPNTVFLGALSALCDRVSVENVQEAIR 149
Cdd:PRK05844   80 IENIFANEKEDTKYIITTHLSKEELIEKkpelkgkkvflVDCIKISMETIGRPIPNTPMLGALMKVSGMLEIDAFKEAFK 159

                         170       180
                  ....*....|....*....|..
gi 1196997752 150 QYMPAKLHAKniaIVDAAREAM 171
Cdd:PRK05844  160 KVLGKKLPQK---VIDANMLAI 178
PRK08537 PRK08537
2-oxoacid:ferredoxin oxidoreductase subunit gamma;
3-169 7.62e-19

2-oxoacid:ferredoxin oxidoreductase subunit gamma;


Pssm-ID: 181462 [Multi-domain]  Cd Length: 177  Bit Score: 83.18  E-value: 7.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   3 EILWHGRGGQGAFTAARLLGAAASLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIgDRSAVAKADYVI---------Y 73
Cdd:PRK08537    4 EIRISGFGGQGIILAGVILGRAAALYDGKYAVQTQSYGPEARGGASKSEVVISDEEI-DYPKVISPDILVamsqeaydkY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  74 LDDtllgegweteLKPGGVVLVNSVRMFDDE-------RIAALDADGISAAVLGRPI-PNTVFLGALSALCDRVSVENVQ 145
Cdd:PRK08537   83 LDD----------LKEGGTVIVDPDLVPIREieyekkvKVYKVPFTEIAEEEIGLSIvANIVMLGALTKLTGIVSKEAIE 152

                         170       180
                  ....*....|....*....|....
gi 1196997752 146 EAIRQYMPAKLHAKNIAIVDAARE 169
Cdd:PRK08537  153 KAILDSVPKGTEEKNLMAFEKGYE 176
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 242-375 6.30e-14

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 66.61  E-value: 6.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 242 KNAGWRNLRPVIDAASCTGCLQCYLHCPDGtvykvpsacrptepadaaaspgtrsrddaegsraevspegtscgarfasa 321
Cdd:COG1144    16 KTGGWRVERPVVDEDKCIGCGLCWIVCPDG-------------------------------------------------- 45

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1196997752 322 ipAISGTGEtlagslgepacafAPVAIDLDFCKGCGICAKACKFGSITMILESE 375
Cdd:COG1144    46 --AIRVDDG-------------KYYGIDYDYCKGCGICAEVCPVKAIEMVPEEK 84
PorD_KorD TIGR02179
2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number ...
 238-373 3.11e-12

2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of delta subunits, representing mostly pyruvate, 2-ketoisovalerate, and 2-oxoglutarate specific enzymes. The delta subunit is the smallest and resembles ferredoxins.


Pssm-ID: 131234 [Multi-domain]  Cd Length: 78  Bit Score: 61.58  E-value: 3.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 238 YLTVKNAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKVpsacrptepadaaaspgtrsrddaEGSRAEvspegtscgar 317
Cdd:TIGR02179   7 SVANKTGDWRVFKPVVDKEKCIKCKNCWLYCPEGAIQED------------------------EGGFVG----------- 51

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1196997752 318 fasaipaisgtgetlagslgepacafapvaIDLDFCKGCGICAKACKFGSITMILE 373
Cdd:TIGR02179  52 ------------------------------IDYDYCKGCGICANVCPVKAIEMVRE 77
PRK08338 PRK08338
2-oxoacid:ferredoxin oxidoreductase subunit gamma;
2-169 7.79e-11

2-oxoacid:ferredoxin oxidoreductase subunit gamma;


Pssm-ID: 181394 [Multi-domain]  Cd Length: 170  Bit Score: 60.33  E-value: 7.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   2 IEILWHGRGGQGAFTAARLLGAAASLDdGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDrSAVAKADYVIYLDDTllge 81
Cdd:PRK08338    1 MQIRFAGIGGQGVVLAGVILGEAAAIE-GLNVLQTQDYSSASRGGHSIADVIISKEPIYD-VMVTKADVLVALHQL---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  82 GWET---ELKPGGVVLVNSVRMFDDE--------RIAAlDADGISAAVlgrpipNTVFLGALSALCDRVSVENVQEAIRQ 150
Cdd:PRK08338   75 GYETaksSLKEDGLLIIDTDLVKPDRdyigapftRIAE-ETTGLALTV------NMVALGYLVAKTGVVKKESVEEAIRR 147

                         170
                  ....*....|....*....
gi 1196997752 151 YMPAKLHAKNIAIVDAARE 169
Cdd:PRK08338  148 RVPKGTEEINIKAFRKGYE 166
PRK06853 PRK06853
indolepyruvate oxidoreductase subunit beta; Reviewed
 4-170 2.23e-09

indolepyruvate oxidoreductase subunit beta; Reviewed


Pssm-ID: 180732 [Multi-domain]  Cd Length: 197  Bit Score: 56.41  E-value: 2.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   4 ILWHGRGGQGAFTAARLLGAAAsLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVI---------YL 74
Cdd:PRK06853    6 ILIVGVGGQGILLASKILGEAA-LAAGYDVKVSEVHGMSQRGGSVVSHVRFGDEVYSPLIPEGKADLLLafeplealrYL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  75 DDtllgegweteLKPGGVVLVNSVRM------------FDDERIAA-----------LDADGIsAAVLGRPIP-NTVFLG 130
Cdd:PRK06853   85 PY----------LKKGGKVVVNTQPIvpvpvslglakyPEDEEILEelkklgikvyvIDAEKI-AKEAGNIKAaNVVLLG 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1196997752 131 ALSALCDrVSVENVQEAIRQYMPAKLHAKNIAIVDAAREA 170
Cdd:PRK06853  154 ALAKFLP-IDEETLEEAIKERVPPKFVEVNLKAFEAGREA 192
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
246-375 8.06e-09

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 53.03  E-value: 8.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 246 WRNLRPVIDAASCTGCLQCYLHCPDGTVYkvpsacrptepadaaaspgtrsrddaegsraeVSPEGTscgarfasaipai 325
Cdd:PRK09623   41 WRTFMPVVDESKCVKCYICWKFCPEPAIY--------------------------------IKEDGY------------- 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1196997752 326 sgtgetlagslgepacafapVAIDLDFCKGCGICAKACKFGSITMILESE 375
Cdd:PRK09623   76 --------------------VAIDYDYCKGCGICANECPTKAITMVKEEK 105
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 242-375 1.19e-06

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 46.56  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 242 KNAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKvpsacrptepadaaaspgtrsrdDAEGSraevspegtscgarfasa 321
Cdd:PRK09624   37 KTGSWRVFMPEFNRDKCVRCYLCYIYCPEPAIYL-----------------------DEEGY------------------ 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1196997752 322 ipaisgtgetlagslgepacafaPVaIDLDFCKGCGICAKACKFGSITMILESE 375
Cdd:PRK09624   76 -----------------------PV-FDYDYCKGCGICANECPTKAIEMVRETK 105
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 345-370 5.10e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 38.11  E-value: 5.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 1196997752 345 PVAIDLDFCKGCGICAKACKFGSITM 370
Cdd:COG2221     9 PPKIDEEKCIGCGLCVAVCPTGAISL 34
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 345-375 6.45e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 39.30  E-value: 6.45e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1196997752 345 PVAIDLDFCKGCGICAKACKFGSITMILESE 375
Cdd:cd10549    34 GPEIDEDKCVFCGACVEVCPTGAIELTPEGK 64
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 346-371 8.11e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 37.40  E-value: 8.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 1196997752 346 VAIDLDFCKGCGICAKACKFGSITMI 371
Cdd:COG1149     6 PVIDEEKCIGCGLCVEVCPEGAIKLD 31
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 345-376 1.05e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 37.33  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1196997752 345 PVAIDLDFCKGCGICAKACKFGSITMILESEA 376
Cdd:COG4231    45 KAVIDPDLCIGCGSCVQVCPVDAIKLEKRVPE 76
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 338-370 2.40e-03

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 37.75  E-value: 2.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1196997752 338 EPACAFA------------PVAIDLDFCKGCGICAKACKFGSITM 370
Cdd:cd04410    55 DPPCVKAcptgaiykdedgIVLIDEDKCIGCGSCVEACPYGAIVF 99
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 346-369 3.94e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 34.53  E-value: 3.94e-03
                          10        20
                  ....*....|....*....|....
gi 1196997752 346 VAIDLDFCKGCGICAKACKFGSIT 369
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGAIT 24
PRK06274 PRK06274
indolepyruvate oxidoreductase subunit beta;
8-175 4.52e-03

indolepyruvate oxidoreductase subunit beta;


Pssm-ID: 235765 [Multi-domain]  Cd Length: 197  Bit Score: 38.11  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752   8 GRGGQGAFTAARLLGAAAsLDDGRHALAFPSFGPERRGAPMRAFTKLSDEPIGDRSAVAKADYVIYLddtllgEGWETE- 86
Cdd:PRK06274    9 GVGGQGVLLASRILANAA-MNEGFHVRTAETLGMSQREGSVISHLRFGDEISSPLIPEGQADLLLAL------EPAEVAr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752  87 ----LKPGGVVLVNSVRMF----------DDE-----------RIAALDADGIsAAVLGRPIP-NTVFLGALSAlCDRV- 139
Cdd:PRK06274   82 nlhfLKKGGKIIVNAYAIHpattvgsekyDPEkeikfakekicDVICIDFTKL-ADEIGNPRSlNVIMLGAAFG-AGLLp 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1196997752 140 -SVENVQEAIRQYMPAKLHAKNIAivdAAREAMGEVQ 175
Cdd:PRK06274  160 lSKESVLETIEAELPEKLREINLA---AFELGIELIS 193
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 348-371 4.58e-03

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 39.00  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....
gi 1196997752 348 IDLDFCKGCGICAKACKFGSITMI 371
Cdd:COG1245    46 ISEELCIGCGICVKKCPFDAISIV 69
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 348-370 6.40e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 36.61  E-value: 6.40e-03
                          10        20
                  ....*....|....*....|...
gi 1196997752 348 IDLDFCKGCGICAKACKFGSITM 370
Cdd:cd10549     3 YDPEKCIGCGICVKACPTDAIEL 25
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
348-371 6.43e-03

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 38.64  E-value: 6.43e-03
                          10        20
                  ....*....|....*....|....
gi 1196997752 348 IDLDFCKGCGICAKACKFGSITMI 371
Cdd:PRK13409   46 ISEELCIGCGICVKKCPFDAISIV 69
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 252-274 6.89e-03

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 35.85  E-value: 6.89e-03
                          10        20
                  ....*....|....*....|...
gi 1196997752 252 VIDAASCTGCLQCYLHCPDGTVY 274
Cdd:PRK09626   49 VVHPESCIGCRECELHCPDFAIY 71
RDH TIGR02486
reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S ...
 351-369 7.74e-03

reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.


Pssm-ID: 274158  Cd Length: 314  Bit Score: 37.80  E-value: 7.74e-03
                          10
                  ....*....|....*....
gi 1196997752 351 DFCKGCGICAKACKFGSIT 369
Cdd:TIGR02486 205 KFCETCGKCADECPSGAIS 223
NapF COG1145
Ferredoxin [Energy production and conversion];
236-371 9.05e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 37.39  E-value: 9.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196997752 236 AGYLTVKNAGWRNLRPVIDAASCTGCLQCYLHCPDGTVYKVPSACRPTEPADAAAspgtrsrDDAEGSRAEVSPEGTSCG 315
Cdd:COG1145    74 IGIGAGEIVRVGIAAADLNLKAVALVLLLALAVAGAAKRLIISAVKLVAGLVVAA-------GEVLLVIAAALAEAGLAI 146

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1196997752 316 ARFASAIPAISGTGETLAGSLGEPACAFAPVAIDLDFCKGCGICAKACKFGSITMI 371
Cdd:COG1145   147 LGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLK 202
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 348-371 9.49e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 34.70  E-value: 9.49e-03
                          10        20
                  ....*....|....*....|....
gi 1196997752 348 IDLDFCKGCGICAKACKFGSITMI 371
Cdd:COG1149    38 VDPDLCTGCGACVGVCPTGAITLE 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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