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Conserved domains on  [gi|1198853908|ref|WP_086971669|]
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GNAT family N-acetyltransferase [Vibrio coralliirubri]

Protein Classification

GNAT family protein( domain architecture ID 106742)

GNAT (Gcn5-related N-acetyltransferase) family protein similar to N-acetyltransferases that catalyze the transfer of an acetyl group from acetyl-CoA to a substrate

PubMed:  15581578

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PhnO super family cl42766
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 44-122 2.46e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


The actual alignment was detected with superfamily member COG0454:

Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 49.28  E-value: 2.46e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1198853908  44 LVAEEADVLLGFKIGYELDQDTFYSWFGGVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRNQFPAMLRLLLRNGY 122
Cdd:COG0454    37 IAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGF 115
 
Name Accession Description Interval E-value
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 44-122 2.46e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 49.28  E-value: 2.46e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1198853908  44 LVAEEADVLLGFKIGYELDQDTFYSWFGGVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRNQFPAMLRLLLRNGY 122
Cdd:COG0454    37 IAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGF 115
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
72-125 2.91e-05

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 41.84  E-value: 2.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1198853908  72 GVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRNQFPAMLRLLLRNGYLIE 125
Cdd:PRK10975  133 AVFPGAQGRGIGARLMQAALNWCQARGLTRLRVATQMGNLAALRLYIRSGANIE 186
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-122 3.10e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 40.96  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198853908  27 ESVASLSERLAGKKNLILVAEEADVLLGFKIGYELDQDTFYSWFGG--VSPLARNKGVAQAQLDAQEQWAQEQGYRQLKV 104
Cdd:pfam00583  19 EPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGlaVAPEYRGKGIGTALLQALLEWARERGCERIFL 98

                          90
                  ....*....|....*...
gi 1198853908 105 KSRNQFPAMLRLLLRNGY 122
Cdd:pfam00583  99 EVAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-102 4.43e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.48  E-value: 4.43e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1198853908  43 ILVAEEADVLLGFKIGYELDQDTFYSWFG--GVSPLARNKGVAQAQLDAQEQWAQEQGYRQL 102
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGdlAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
 
Name Accession Description Interval E-value
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 44-122 2.46e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 49.28  E-value: 2.46e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1198853908  44 LVAEEADVLLGFKIGYELDQDTFYSWFGGVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRNQFPAMLRLLLRNGY 122
Cdd:COG0454    37 IAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGF 115
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
28-140 2.48e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 44.60  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198853908  28 SVASLSERLAGKKN---LILVAEEADVLLGFKIGYELDQDTFYSWFG----GVSPLARNKGVAQAQLDAQEQWAQEQGYR 100
Cdd:COG1247    36 SEEEREAWFAAILApgrPVLVAEEDGEVVGFASLGPFRPRPAYRGTAeesiYVDPDARGRGIGRALLEALIERARARGYR 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1198853908 101 QLKVKSRNQFPAMLRLLLRNGyliekFEEKEDINDHRIHF 140
Cdd:COG1247   116 RLVAVVLADNEASIALYEKLG-----FEEVGTLPEVGFKF 150
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
72-125 2.91e-05

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 41.84  E-value: 2.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1198853908  72 GVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRNQFPAMLRLLLRNGYLIE 125
Cdd:PRK10975  133 AVFPGAQGRGIGARLMQAALNWCQARGLTRLRVATQMGNLAALRLYIRSGANIE 186
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-122 3.10e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 40.96  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198853908  27 ESVASLSERLAGKKNLILVAEEADVLLGFKIGYELDQDTFYSWFGG--VSPLARNKGVAQAQLDAQEQWAQEQGYRQLKV 104
Cdd:pfam00583  19 EPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGlaVAPEYRGKGIGTALLQALLEWARERGCERIFL 98

                          90
                  ....*....|....*...
gi 1198853908 105 KSRNQFPAMLRLLLRNGY 122
Cdd:pfam00583  99 EVAADNLAAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 72-144 1.47e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 38.48  E-value: 1.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1198853908  72 GVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRNQFPAMLRLLLRNGYLIEKfEEKEDINDHRIHFLKQI 144
Cdd:COG0456    20 AVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVG-ERPNYYGDDALVMEKEL 91
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
27-102 1.54e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 39.30  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198853908  27 ESVASLSERLAGkkNLILVAEEADVLLGF----KIGYELDQDTFYSWFGGVSPLARNKGVAQAQLDAQEQWAQEQGYRQL 102
Cdd:COG3153    27 ELVDRLREDPAA--GLSLVAEDDGEIVGHvalsPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAV 104
COG3375 COG3375
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
41-100 2.18e-04

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 442602 [Multi-domain]  Cd Length: 271  Bit Score: 39.54  E-value: 2.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1198853908  41 NLILVAEEADVLLGFKI---GYELDQDTFYSWFGGVSPLARNKGVAQAQLDAQEQWAQEQGYR 100
Cdd:COG3375    48 GYVLGAFDGGELVGFSFgfpGFRPGGLYLHSHMAGVLPEYRGRGVGYALKLHQREWALERGVT 110
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-102 4.43e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.48  E-value: 4.43e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1198853908  43 ILVAEEADVLLGFKIGYELDQDTFYSWFG--GVSPLARNKGVAQAQLDAQEQWAQEQGYRQL 102
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGdlAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 43-144 9.74e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 36.89  E-value: 9.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198853908  43 ILVAEEADVLLGFKIGYELDQDTFYSWFGGVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRnqfPAMLRLLLRNGY 122
Cdd:COG1246    30 FWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTT---SAAIHFYEKLGF 106

                          90       100
                  ....*....|....*....|....*
gi 1198853908 123 -LIEKFE--EKEDINDHRIHFLKQI 144
Cdd:COG1246   107 eEIDKEDlpYAKVWQRDSVVMEKDL 131
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 39-109 5.90e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 33.97  E-value: 5.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1198853908  39 KKNLILVAEEADVLLGFKIGYELDQDTFYSWFG-GVSPLARNKGVAQAQLDAQEQWAQEQGYRQLKVKSRNQ 109
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELRlAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNR 72
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
73-122 7.59e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 33.73  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1198853908  73 VSPLARNKGVAQAQLDAQEQWAQEQGYRQ--LKVKSRNqfPAMLRLLLRNGY 122
Cdd:COG3393    23 THPEYRGRGLASALVAALAREALARGARTpfLYVDADN--PAARRLYERLGF 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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