|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
1-408 |
7.37e-99 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 301.35 E-value: 7.37e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:cd13143 17 MLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFSTALLLSLILGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 81 ILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF 160
Cdd:cd13143 97 LLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 161 PCKLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMF--KKWFDVASLGVSSFITEVSSGIVILVFNFIILEL 238
Cdd:cd13143 177 VLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLslKIIKEILALGFPSFLMQLSSSVVTIVLNLTLLGY 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 239 MGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFN 318
Cdd:cd13143 257 GGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILLLFPEQIVSLFT 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 319 PEglEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSSLLGMTGVWLAFPVSE 398
Cdd:cd13143 337 DD--PELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRLFGLDGIWLAFPLAE 414
|
410
....*....|
gi 1199646292 399 LLVLFVAVTL 408
Cdd:cd13143 415 ILTLLLALIL 424
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-406 |
3.32e-77 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 245.82 E-value: 3.32e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:COG0534 21 NLLQSLYGLVDTIFVGR-LGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 81 ILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF 160
Cdd:COG0534 100 LLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIF 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 161 PCKLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMFKK--WFDVASLGVSSFITEVSSGIVILVFNFIILEL 238
Cdd:COG0534 180 GGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRkiLKRILRIGLPAGLQQLAESLGFLVLNALVARL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 239 mGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFN 318
Cdd:COG0534 260 -GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFT 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 319 PEglEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSSL-LGMTGVWLAFPVS 397
Cdd:COG0534 339 DD--PEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLgLGLTGVWLALPIG 416
|
....*....
gi 1199646292 398 ELLVLFVAV 406
Cdd:COG0534 417 EVLRALLLL 425
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
7-408 |
2.49e-53 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 184.04 E-value: 2.49e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 7 YILADTFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCG 86
Cdd:PRK09575 31 YQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRILTTGLLLLLLLGPIVSVIL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 87 LFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPCKLGM 166
Cdd:PRK09575 111 FLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALINIVLDYLFIGWLDWGL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 167 FGAIAATAMAPGISLILMM--FRTLKGKNSFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFNFIILELMGNVGV 244
Cdd:PRK09575 191 TGAAIATALAQLVVTVLGLgyFFSSRANIRLTLKELRFNWSLAPKIVLLGSSSFFMYLYGSFVVALHNRLFMEYGSALTV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 245 AAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNPEGlEE 324
Cdd:PRK09575 271 GAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLNLFPETMIALFNSGD-SE 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 325 LSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVlRGFVIIIPCAFIMSSLLGMTGVWLAFPVSEL-LVLF 403
Cdd:PRK09575 350 LIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISI-GNMLIQLPFLFILPKWLGVDGVWLAMPLSNIaLSLV 428
|
....*
gi 1199646292 404 VAVTL 408
Cdd:PRK09575 429 VAPML 433
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
5-415 |
1.01e-50 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 176.50 E-value: 1.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 5 SCYILADTFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIF 84
Cdd:cd13138 20 QLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 85 CGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPCKL 164
Cdd:cd13138 100 LGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHM 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 165 GMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMFKKWF--DVASLGVSSFITEVSSGIVILVFNFIILElMGNV 242
Cdd:cd13138 180 GVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEIlkEILKIGLPSALQQSLVSISFLIINSIVNS-YGVV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 243 GVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNPEgl 322
Cdd:cd13138 259 ASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSD-- 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 323 EELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSSL--LGMTGVWLAFPVSELL 400
Cdd:cd13138 337 PEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLtgLGLFGIWLAMPISNIL 416
|
410
....*....|....*
gi 1199646292 401 VLFVAVTLKIREGRK 415
Cdd:cd13138 417 SAIICIIYYRKGRWK 431
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-411 |
3.69e-48 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 169.72 E-value: 3.69e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 7 YILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCG 86
Cdd:cd13144 27 YNIVDSIFVAR-LGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLLLALLSYLLFLLLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 87 LFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPC---- 162
Cdd:cd13144 106 LFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILDPILIFGLfgfp 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 163 KLGMFGAIAATAMAPGISLILMMFRtLKGKN---SFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFNFIILELm 239
Cdd:cd13144 186 AMGIAGAAIATVIGQILAMFLAFFF-LLRKNkdvQPDLRLFRPSLRIIKEIYAVGLPSIIMQAISSVMVFGLNKILAGF- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 240 GNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNP 319
Cdd:cd13144 264 GPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNA 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 320 EglEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSSLLGMTGVWLAFPVSEL 399
Cdd:cd13144 344 S--EEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWLLAKMFGLNGVWWSFPIAEI 421
|
410
....*....|..
gi 1199646292 400 LVLFVAVTLKIR 411
Cdd:cd13144 422 VSFLLSLLFLKR 433
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
1-405 |
1.50e-43 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 157.10 E-value: 1.50e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:cd12082 8 MLLQTLYNLVDTFFLGR-LLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 81 ILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF 160
Cdd:cd12082 87 LLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 161 ---PCKLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMFKK--WFDVASLGVSSFITEVSSGIVILVFNFII 235
Cdd:cd12082 167 glgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLelLRRLLRIGLPSAIQNSLLSLGLLIIVAIV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 236 LELMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIG 315
Cdd:cd12082 247 AAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 316 AFNPEglEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSSL-LGMTGVWLAF 394
Cdd:cd12082 327 LFTND--PEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLgLGLYGIWLAL 404
|
410
....*....|.
gi 1199646292 395 PVSELLVLFVA 405
Cdd:cd12082 405 VISLILAALVL 415
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
7-400 |
1.70e-38 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 143.81 E-value: 1.70e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 7 YILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCG 86
Cdd:cd13137 20 VGLVDVFMVGR-LGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLPLALLG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 87 LFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPC---- 162
Cdd:cd13137 99 LLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYVLIFGLwgfp 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 163 KLGMFGAIAATAMAPGISLILMMFRTLKGKN--SFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFNFIILeLMG 240
Cdd:cd13137 179 GLGVAGAALATVISRVVGALLLLFLLLRGRLpiKISFKGFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVA-SYG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 241 NVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNPE 320
Cdd:cd13137 258 TAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPD 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 321 GleELSRCASDGLRLYFPGFFFAGVNIITA-VFFGAWDKpAPSFIISVLRGFVIIIPCAFIMSSLLGM--TGVWLAFPVS 397
Cdd:cd13137 338 P--EVIELGVLYLRIVALSQPFLAISFVLSgALRGAGDT-RPPLIINLISMWLVRLPLAYLLGFVLGLglTGIWLAMFVD 414
|
...
gi 1199646292 398 ELL 400
Cdd:cd13137 415 TIV 417
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
1-405 |
1.98e-37 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 141.14 E-value: 1.98e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISqGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:cd13147 22 MLLQTLYNLVDAIWVA-GLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSILLGLIISI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 81 ILIFCGLFFSGNIARLLGAnDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF 160
Cdd:cd13147 101 ILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNIILDPIFIY 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 161 PCKLGMFGAIAATAMAPGISLILMMFRTLKGKN---SFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFNFIILE 237
Cdd:cd13147 180 TLGLGIAGAAWATVISMLISSLVLLYWFFVKKDtyvSLSLKNFKFDKKIVKDILKVGIPASLEQLIMSVLMIILNLILVI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 238 LMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAF 317
Cdd:cd13147 260 VAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLF 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 318 N-PEGLEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRG--FVIIIPCAFIMSSLLGMTGVWLAF 394
Cdd:cd13147 340 TySEESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILREliFQVLFAYLFAIVLGLGLFGVWWGI 419
|
410
....*....|.
gi 1199646292 395 PVSELLVLFVA 405
Cdd:cd13147 420 VLGNAIGSIVG 430
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-406 |
1.32e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 136.17 E-value: 1.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 7 YILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCG 86
Cdd:cd13142 30 YNLADTFWLGR-LGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSFVIILSLILAVLG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 87 LFFSGNI-ARLLGANDEVYSMTLIYLKVMLLFSPL----FMFNNLMtcfvRNDGAPNLAMAAMIVGSLGNIIMDYVFIFP 161
Cdd:cd13142 109 YILSRPLlLLLIGAPEEVYPLALAYLRIIFLGLPFmfifFVFNSLL----RGIGDTKTPMKIMFGSVLLNVILDPLLIFG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 162 C----KLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGFaKTKHMFKKWF---DVASLGVSSFITEVSSGIVILVFNFI 234
Cdd:cd13142 185 IgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKI-SLRDLKPDWEwlkKIFRIGLPSSIEQSARALGFTVMTAL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 235 IlELMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEII 314
Cdd:cd13142 264 V-AGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIV 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 315 GAF--NPEGLEElsrcASDGLRLYFPGF-FFAGVNIITAVFFGAwDKPAPSFIISVLRGFVIIIPCAFIMSSLLGM--TG 389
Cdd:cd13142 343 RVFinDPEVIKE----GADFLRIVAPSFpFFGLFQVINGAFRGS-GHTLTAMIISILRLWVIRIPLAYLLAYVLGLgvTG 417
|
410
....*....|....*..
gi 1199646292 390 VWLAFPVSELLVLFVAV 406
Cdd:cd13142 418 IWIAMAISNIVAALIAL 434
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-406 |
2.19e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 115.86 E-value: 2.19e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:cd13149 22 ILAMLIFNLTDTFFVGK-LGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRLATDSLILSLLLSV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 81 ILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF 160
Cdd:cd13149 101 IVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAALVNVILDPILIF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 161 ----PCKLGMFGAIAAT----AMAPGISLILMMFRtlKGKNSFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFN 232
Cdd:cd13149 181 gfgpIPGMGIAGAAIATvisrALGLGAALYFLHYH--HRLIDFSEPSLKALFRSWKDILSIGIPAALSNILTPLSAAFIT 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 233 FIILELmGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDE 312
Cdd:cd13149 259 ALVATY-GPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYGAILGIVLALFAGW 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 313 IIGAFNPEGleELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSSLLGMTGVWL 392
Cdd:cd13149 338 LASLFSAEP--EVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYVGSHLLGFAGVFI 415
|
410
....*....|....
gi 1199646292 393 AFPVSELLVLFVAV 406
Cdd:cd13149 416 GALAGNLIAGILAY 429
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-400 |
1.71e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 110.28 E-value: 1.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 9 LADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCGLF 88
Cdd:cd13134 24 TIDTFMLSR-YSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLLLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 89 FSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFP----CKL 164
Cdd:cd13134 103 FGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGNYLLIFGwfglPKL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 165 GMFGAIAATAMAPGISLILMMFRTLKGKN-----SFGFAKTKHMFKKWFdvaSLGVSSFITEVSSGIVILVFNFIIlELM 239
Cdd:cd13134 183 GVAGVAISTVISRAVGLVLLFILLFRKLKirfrlKDLRPFPKKLLKKIL---KIGLPSAGEELSYNLSQTVITAFI-ARL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 240 GNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAF-- 317
Cdd:cd13134 259 GTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLLALFREPILGLFtd 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 318 NPEGLEELSRCasdgLRLYFPGFFFAGVNIITA-VFFGAWDKPAPsFIISVLRGFVIIIPCAFIMSSLLGM--TGVWLAF 394
Cdd:cd13134 339 DPEIIALGKTL----LLISILLEPGRAFNIVLIgSLRAAGDARFP-VLIGIISMWGISVPLAYLLGIVLGLglLGVWIAF 413
|
....*.
gi 1199646292 395 PVSELL 400
Cdd:cd13134 414 AADEWV 419
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-417 |
9.74e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 102.69 E-value: 9.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 5 SCYILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIF 84
Cdd:cd13139 31 SLFAVVDLYFVSR-LGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILLGVALSLILSI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 85 CGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF---- 160
Cdd:cd13139 110 LGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNIILDPLFIFglgp 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 161 PCKLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMF-----KKWFDVASLGVSSFITEVSSGIVILvfnfII 235
Cdd:cd13139 190 IPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLdwaiiKKIIKIAVGGILQFLIASSSWIFLV----RI 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 236 LELMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIG 315
Cdd:cd13139 266 IAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVS 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 316 AFNPEglEELSRCASDGLRLYFPGFFFAGVN-IITAVFFGAWDKPAPSfIISVLRGFVIIIPCAFIMSSLLGM--TGVWL 392
Cdd:cd13139 346 FFTTD--PEVIAIAVEALRIISLGYIFYGYGmVLSQAFNGAGDTKTPT-LINLVGFWLFQIPLAYLLARHLNLgpKGVFI 422
|
410 420
....*....|....*....|....*
gi 1199646292 393 AFPVSElLVLFVAVTLKIREGRKVT 417
Cdd:cd13139 423 AIPIAE-TVLAIAAIILFRRGKWKT 446
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
1-318 |
1.16e-23 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 100.78 E-value: 1.16e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISqGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:TIGR00797 6 NILQPLLGLVDTAFVG-HLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 81 ILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF 160
Cdd:TIGR00797 85 PVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILIF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 161 PcKLGMF---GAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMFKKWFDVASLGVSsfiTEVSSGIVILVFNFIILE 237
Cdd:TIGR00797 165 G-KFGFLgivGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLG---LPIAFRVILESLSFALLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 238 LM----GNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEI 313
Cdd:TIGR00797 241 LLvarlGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREFI 320
|
....*
gi 1199646292 314 IGAFN 318
Cdd:TIGR00797 321 ARLFT 325
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-412 |
1.01e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 99.52 E-value: 1.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 5 SCYILADTFFISqGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIF 84
Cdd:cd13140 22 MAYNLTDMFWVG-RLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 85 CGLFFSGNIARLLGAND-EVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPC- 162
Cdd:cd13140 101 LLLLFAKPLIGFFNLGDaEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIFGFg 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 163 ---KLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHM--FKKWFDVASLGVSSFItevsSGIVILVFNFIILE 237
Cdd:cd13140 181 pfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRpdRKYIKEILKLGLPVAL----QSILFALISMILAR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 238 LM---GNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEII 314
Cdd:cd13140 257 IIasfGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLF 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 315 GAFNPEglEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLrGFVIIIPCAFIMSS-LLGMTGVWLA 393
Cdd:cd13140 337 SLFIPD--PETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIV-FNGLRIPLALLLSPtGLGLNGIWWA 413
|
410 420
....*....|....*....|..
gi 1199646292 394 FPVSELL---VLFVAVTLKIRE 412
Cdd:cd13140 414 ISISSILkgiILTIWFLLYKKK 435
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-406 |
2.13e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 95.55 E-value: 2.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 7 YILADTFFISQ--GIGPDGLTALNIALPVFNIM--NGAGLMIGMGGAARFSIlkASGDHKKANSVFTSCFCLASVISIIL 82
Cdd:cd13146 27 YNITDTIWISMidPSDPALVGGIGLVFPLGMIFlaLGNGIQVGVSSLLARAI--GAQRAKELDQAADSGLALALLAATVI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 83 IFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPC 162
Cdd:cd13146 105 VVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 163 KLGMFGAIAATAMAPGISL--ILMMFRTLKGKNSFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFNFIILELMG 240
Cdd:cd13146 185 DMGVKGAALATVLAQAISLlyLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLPQMLLQLISSISFLIYNRIIIDIDP 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 241 NVgVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNPe 320
Cdd:cd13146 265 VA-MTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTT- 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 321 gLEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSSLL--GMTGVWLAFPVSE 398
Cdd:cd13146 343 -VPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFgkGITGVYFGIVSAN 421
|
....*...
gi 1199646292 399 LLVLFVAV 406
Cdd:cd13146 422 FFTALLAM 429
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-393 |
1.08e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 93.43 E-value: 1.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 7 YILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCG 86
Cdd:cd13145 28 FNVVDTFFAGK-ISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 87 LFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF--PCKL 164
Cdd:cd13145 107 LFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIFggGGIP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 165 GM-FGAIA-ATAMAPGISLILMMFRTLKGKNSFGFaKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFnFIILELMGNV 242
Cdd:cd13145 187 AMgVSGIAlATIISQFIGMFYLLYKVRKSGIISGC-RLRDFIPRLDVYKEILKQGFPASLNMMTIGLGI-FVITYFVGQF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 243 G---VAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAF-- 317
Cdd:cd13145 265 GdeaVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFtn 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1199646292 318 NPEGLeelsRCASDGLRL-YFPGFFFAGVNIITAVFFGAwDKPAPSFIISVLRGFVIIIPCAFIMSSLLG--MTGVWLA 393
Cdd:cd13145 345 DPAVI----AIGAGYLRIdALIFYAYVVLFISVSVLQGL-KRPIFALWIGLYRQLVGPALVFWLLVNVLGlgVTGIWWG 418
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
9-394 |
4.87e-18 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 85.31 E-value: 4.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 9 LADTFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCGLF 88
Cdd:cd13136 24 LVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALLVRALLLALAIGLLLILLQSP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 89 FSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPCKLGMFG 168
Cdd:cd13136 104 LLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGNVVNIVLDPLFVFGLGWGVAG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 169 AIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMF--KKWFDVASLGVSSFITevsSGIVILVFNFIIL--ELMGNVGV 244
Cdd:cd13136 184 AALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPskAALKRLFKLNRDIFIR---TLALLAAFLFFTAlaARLGDVIL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 245 AAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNPEglEE 324
Cdd:cd13136 261 AANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDD--PA 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1199646292 325 LSRCASDGLRLYFPGFFFAGVN-IITAVFFGAWDkpAPSFIISVLRGFVIIIPCAFIMSSLLGMTGVWLAF 394
Cdd:cd13136 339 VLALAATYLPWLALLPPIGALAfVLDGIFIGATD--TRYLRNSMLVSLAVFLPLLFLLVPLWGNHGLWLAL 407
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-414 |
7.71e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 84.89 E-value: 7.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYIL---ADTFFISQgIGPDGLTALNIAlpvfNIMNGAGLMIGMGGAARFSILKA----SGDHKKANSVFTSCFC 73
Cdd:cd13133 15 VLSMLSQTVmgfTDRAFLGR-LSEVALAASGPA----GVLYFAILMLFFGLSSGVQVFVAqyngAGRYSRIGRVLWQGLY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 74 LASVISIILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNII 153
Cdd:cd13133 90 FSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNIV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 154 MDYVFIF-----PcKLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVI 228
Cdd:cd13133 170 LDYALIFgklgfP-AMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFDRELLRRILRLGLPSGLQFFLDV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 229 LVFN--FIILELMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAV 306
Cdd:cd13133 249 GAFTvfFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLGILF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 307 FIFTDEIIGAFNPEGLEELSRCASDGLrLYFPGF--FFAGVNIITA-VFFGAWDKPAPSFIISVLRGFVIIIPCAFIMSS 383
Cdd:cd13133 329 LLFPELLLSIFTPGADFALIAELAVPL-LRFVAAyiLFDALALVFAgALRGAGDTRFVMLAELIVAWLYLLPPAYLLVVL 407
|
410 420 430
....*....|....*....|....*....|.
gi 1199646292 384 LLGMTGVWLAFPVSeLLVLFVAVTLKIREGR 414
Cdd:cd13133 408 GAGLAGAWTVETVY-VIVLALIFLLRFRSGK 437
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
9-320 |
1.48e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 81.01 E-value: 1.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 9 LADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFcGLF 88
Cdd:cd13131 24 FVDTVMAGR-LGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPLML-LLW 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 89 FSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIF----PCKL 164
Cdd:cd13131 102 LAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIFgkfgLPAL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 165 GMFGAIAATAMAPGISLILMMFRTLKGKNSFGFAKTKHM----FKKWFDVASLGV---SSFITEVSsgivilVFNFIILe 237
Cdd:cd13131 182 GGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFwrpdWARLKELLRLGLpigLTIFFEVS------LFAAVAL- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 238 LMGNVG---VAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEII 314
Cdd:cd13131 255 LMGRLGttvLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAALTALLLLLFPEQIA 334
|
....*.
gi 1199646292 315 GAFNPE 320
Cdd:cd13131 335 GLYTND 340
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
1-157 |
7.24e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 71.83 E-value: 7.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISqGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:pfam01554 6 NLLQSLYSLIDTLFVG-HLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSL 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1199646292 81 ILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYV 157
Cdd:pfam01554 85 PIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNYL 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
19-317 |
4.28e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 70.40 E-value: 4.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 19 IGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCGLFFSGNIARLLG 98
Cdd:cd13135 31 ISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVYNSIIGVILFLLWLFGARIIFVLFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 99 ANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFP----CKLGMFGAIAATA 174
Cdd:cd13135 111 VDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVILDYVLIFGnfgfPRLGIIGAAIATT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 175 MAPGISLIL--MMFRTLKGKN--SFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVFNfIILELMGNVGVAAYGIV 250
Cdd:cd13135 191 IANVLNLIIlvYLCRKIKKLTfkLSNTKVLKANIRPYKFTIKLGLPLGGEEFLWNIGNLAVI-RILNRIGELALGIYTLV 269
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1199646292 251 ANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAF 317
Cdd:cd13135 270 FGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILSLF 336
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
9-320 |
1.49e-10 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 62.59 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 9 LADTFFISQgIGPDGLTALNIALPVFNImNGAGLMIGMGGAAR--FSILKASGDHKKANSVFTSCFCLASVISIiLIFCG 86
Cdd:cd13132 24 VVSVVFVGH-LGKLELAAASLASSFANV-TGFSILLGLASALDtlCGQAFGAKNYKLVGVYLQRALVILLLCCV-PISLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 87 LFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPCKLGM 166
Cdd:cd13132 101 WLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVALLLNILLNYLLVFVLGLGF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 167 FGAIAATAMAPGISLILMMFRTLKGKN--SFGFAKTKHMFKKWFDVASLGVSSFI---TEVSSgivilvFNFIIL---EL 238
Cdd:cd13132 181 IGAALATSISYWLIVVLLLLYIFFSKGhkATWGGFSREAFRGWGPFLKLAIPSALmlcLEWWA------FEILVLlagLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 239 MGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFN 318
Cdd:cd13132 255 PGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFT 334
|
..
gi 1199646292 319 PE 320
Cdd:cd13132 335 SD 336
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-345 |
1.36e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 59.59 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISQgIGPDGLTALNIALPVFNIM----NGAglmigMGGAARFSILKASG--DHKKANSVFTSCFCL 74
Cdd:cd13148 25 LLVQTLVGLAETYFVGQ-LGTDALAGVALVFPLLMLTqmmsNGA-----MGGGVSSAIARALGagDRERAEALVWHALVI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 75 ASVISIILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIM 154
Cdd:cd13148 99 ALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGAVVQIPL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 155 DYVFIFPC----KLGMFGAIAATAMAPGISLILMMFRTLKGKN--SFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVI 228
Cdd:cd13148 179 SPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLASGRSrlRLRLRALRLERRLFRDILRVGLLAALSPLQTNLTV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 229 LVFNFIILELmGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFI 308
Cdd:cd13148 259 LLLTGLVGRF-GTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAVLAGAIGLVLAL 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 1199646292 309 FTDEIIGAFNPEglEELSRCASDGLRLYFPGFFFAGV 345
Cdd:cd13148 338 FPELWLGLFTHD--PAVLAAGASYLRIVGPFYGFFGL 372
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
217-380 |
1.91e-09 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 56.03 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 217 SFITEVSSGIVILVFnfiiLELMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGA 296
Cdd:pfam01554 5 ENLLQSLYSLIDTLF----VGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 297 LSAVLIYVAVFIFTDEIIGAFNPEglEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLrGFVIIIP 376
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQD--EEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINII-SLLLNIP 157
|
....
gi 1199646292 377 CAFI 380
Cdd:pfam01554 158 LNYL 161
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
33-406 |
8.05e-09 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 56.88 E-value: 8.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 33 VFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCGLFFSGNIARLLGANDevysmTLIYLK 112
Cdd:COG2244 44 ALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLSTALLLRLLLSLLLALLLLLLAPFIAALLGEPE-----LALLLL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 113 VMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIImdyvfifpcklgmfGAIAATAMAPGISLILMMFrtlkgk 192
Cdd:COG2244 119 LLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLL--------------LALLLALLGLGLWGLVLKY------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 193 nsfgfaktkhmfkkwfdvaslGVSSFITEVSSGIVILVFNFIILELMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLV 272
Cdd:COG2244 179 ---------------------SLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 273 SKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNPEGLEElsrcASDGLRLYFPGFFFAGVNIITAVF 352
Cdd:COG2244 238 SRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE----AAPVLPILALGALFLALSGVLSNL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1199646292 353 FGAWDKPAPSFIISVLrGFVIIIPCAFIMSSLLGMTGVWLAFPVSELLVLFVAV 406
Cdd:COG2244 314 LLALGRTRLLLIISLI-GAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
14-187 |
6.42e-08 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 54.38 E-value: 6.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 14 FISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCGLFFSGNI 93
Cdd:COG0534 254 ALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 94 ARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPCKLGMFGAIAAT 173
Cdd:COG0534 334 IGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLAL 413
|
170
....*....|....
gi 1199646292 174 AMAPGISLILMMFR 187
Cdd:COG0534 414 PIGEVLRALLLLLR 427
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-376 |
1.97e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 52.70 E-value: 1.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 1 MIGLSCYILADTFFISQgIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISI 80
Cdd:cd13141 24 MIIQTLYFLVDLYFVGQ-LGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLLLAAVLGL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 81 ILIFCGLFFSGNIARLLGANDEVYSMTLIYLkvmLLFSPLFMFNNLMTCF---VRNDGAPNLAMAAMIVGSLGNIIMDYV 157
Cdd:cd13141 103 VVLVLGYLFGRLYLETLAADAATVEAATTYL---YWFIPSLALQFILTVLgaaLRGTGIVKPFMVIQILAVLLNIILAPI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 158 FIFPC----KLGMFGAIAATAMAPGISLILMMFRTLKGKNSFGF--AKTKHMFKKWFDVASLGVSS----FITEVSSGIV 227
Cdd:cd13141 180 LITGWgtgrALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLdlALWRPDLPTWKRLLKIGLPSggefLLTFVYMAVI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 228 ilvfnFIILELMGNVGVAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYVAVF 307
Cdd:cd13141 260 -----YWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALMLVLTLLCQ 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1199646292 308 IFTDEIIGAFNPEglEELSRCASDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLRGFVIIIP 376
Cdd:cd13141 335 LVPELLVTPFSDD--AAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALP 401
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
58-318 |
2.75e-07 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 52.51 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 58 SGDHKKANSVFTSCFCLASVISIILIFCGLFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAP 137
Cdd:PRK01766 81 AGRRERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKT 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 138 NLAMAAMIVGSLGNIIMDYVFIFPcKLGM--FGAIA---ATAMAPGISLILMMFRTLKGKN--SFGFAKTKHM--FKKWF 208
Cdd:PRK01766 161 KPTMVIGFLGLLINIPLNYIFIYG-KFGFpeLGGVGcgvATAIVYWVMFLAMLIYIKRARRfrDFRLFKGLYKpdWAVIK 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 209 DVASLGV---SSFITEVSsgivilVFNFIILeLMGNVG---VAAYGIVANIALVVTAIFTGISQGIQPLVSKSKGEGNYS 282
Cdd:PRK01766 240 RLLKLGLpigLAIFFEVS------LFAVVTL-LVSPLGtvtVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTL 312
|
250 260 270
....*....|....*....|....*....|....*.
gi 1199646292 283 VSRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFN 318
Cdd:PRK01766 313 DARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYT 348
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
12-405 |
5.50e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 45.23 E-value: 5.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 12 TFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSilkASGDHKKANSVFTSCFCLASVISIILIFCGLFFSG 91
Cdd:cd13128 23 RVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREI---ARYRKEKIREIISTSLVLKLILGILALLLLFLFAF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 92 NIARLlgandevYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFpCKLGMFGAIA 171
Cdd:cd13128 100 LIAFY-------DPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILVL-LGGGLIGFAL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 172 ATAMAPGISLILMMFRTLKGKNSFGFAKTKhmFKKWFDVASLGVSSFITEVSSGIVILVFNFIILELMGNVGVAAYGIVA 251
Cdd:cd13128 172 AYLIASVLSAILLLYIYRKKILLPKFFSFD--LKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAY 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 252 NIALVVTAIFTGISQGIQPLVSKSKGEGNYSVsRKIYRYGITAGALSAVLIYVAVFIFTDEIIGAFNPEGLEElsrcASD 331
Cdd:cd13128 250 RIAELLLFIPSAISTALFPRISELYKNDKDEL-KKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP----AAL 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1199646292 332 GLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLrGFVIIIPCAFIMSSLLGMTGVWLAFPVSELLVLFVA 405
Cdd:cd13128 325 VLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI-GALLNVILNLLLIPKYGIIGAAIATLISEFIIFILL 397
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
7-189 |
7.75e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 44.62 E-value: 7.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 7 YILADTFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCG 86
Cdd:cd12082 238 GLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLI 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 87 LFFSGNIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFPCKLGM 166
Cdd:cd12082 318 LLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGL 397
|
170 180
....*....|....*....|...
gi 1199646292 167 FGAIAATAMAPGISLILMMFRTL 189
Cdd:cd12082 398 YGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
19-404 |
1.07e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 40.91 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 19 IGPDGLTALNIALPVFNIMngagLMIGMGG-----AARFSILKASGDHKKANSVFTSCFCLASVISIILIFCGLFFSGNI 93
Cdd:cd13124 25 IGDEGMGLYQMAYPIYGIF----LTLATAGipvaiSKLVAEYNALGDYKGARRIFRVSLILLLILGLVFFLLLFFGAPFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 94 ARLLGANDEVYsMTLIYLKVMLLFSPL-------FMFNNLMTC---------FVRndgapnlaMAAMIVGSLGNIIMDYV 157
Cdd:cd13124 101 AQLLLGDPRLA-PVIRALAPAILIVPLlsvlrgyFQGLQNMTPtavsqvieqIVR--------VIVILVLAYLLLPVGGG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 158 FIFPCKLGMFGAIAAtAMAPGISLILMMFRTLKGKNSFGFAKTKHMFKKWFDVASLGVSSFITEVSSGIVILVF---NFI 234
Cdd:cd13124 172 LYYAAAGATFGAVIG-ALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEILKELLSYAIPITLSSLILPLLQlidSFT 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 235 ILELMGNVGV------AAYGIVANIA----LVVTAIFTGISQGIQPLVSKSKGEGNYSVSRKIYRYGITAGALSAVLIYV 304
Cdd:cd13124 251 VPRRLQAAGLseseatALYGILTGRAqplvQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 305 AVFIFTDEIIGAF--NPEGleelsrcaSDGLRLYFPGFFFAGVNIITAVFFGAWDKPAPSFIISVLrGFVIIIPCAFIMS 382
Cdd:cd13124 331 GLAVLAEPINTLLfgDSEG--------GLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLI-GLLVKIVLNYVLI 401
|
410 420
....*....|....*....|..
gi 1199646292 383 SLLGMTGVWLAFPVSELLVLFV 404
Cdd:cd13124 402 PIFGIYGAAIATVIGFLVAALL 423
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-192 |
1.85e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 40.19 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 12 TFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASGDHKKANSVFTSCFCLASVISIILIFCGLFFSG 91
Cdd:cd13137 249 LLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLLFIFAP 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 92 NIARLLGANDEVYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGN-IIMDYVFIFPCKLGMFGAI 170
Cdd:cd13137 329 PLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVrLPLAYLLGFVLGLGLTGIW 408
|
170 180
....*....|....*....|..
gi 1199646292 171 AATAMAPGISLILMMFRTLKGK 192
Cdd:cd13137 409 LAMFVDTIVRAILLLYRFRKGK 430
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-188 |
7.75e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 38.29 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 11 DTFFISQGIGPDGLTALNIALPVFNIMNGAGLMIGMGGAARFSILKASgDHKKANSVFTSCFCLASVISIILIFCGLFFS 90
Cdd:cd13128 229 DTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKN-DKDELKKLLKKSFKYLFLISLPIAIGLFLFA 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 91 GNIARLLGANDevYSMTLIYLKVMLLFSPLFMFNNLMTCFVRNDGAPNLAMAAMIVGSLGNIIMDYVFIFpcKLGMFGAI 170
Cdd:cd13128 308 EPIITLLFGEE--YLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIP--KYGIIGAA 383
|
170
....*....|....*...
gi 1199646292 171 AATAMAPGISLILMMFRT 188
Cdd:cd13128 384 IATLISEFIIFILLLYLL 401
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
52-411 |
9.28e-03 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 38.20 E-value: 9.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 52 FSILKASGDHKKANSVFTSCFCLASVISIILIFCGLFFSGNIARLL--GANDEVYSMTLIYLKVMLLFSPLFMFNNLMT- 128
Cdd:cd13123 58 FSEYLEKEGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALLGg 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 129 ------CFVrndgapnlamAAMIVGSLGNIIMDYVFIFPCKLGMFG--AIAATAMAPGISLILMMFRTLKgknSFGFAKT 200
Cdd:cd13123 138 ilnahgRFF----------APALAPVLLNLVIIAGLLLLAPLFDLGiyALAWGVLLGGVLQLLVQLPALR---RLGFRFR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 201 KHMFKKWFDVASLGVSSFITEVSSGIVIL--VFNFIILELMGNVGVAAYGIVANIALVVTAIF-TGISQGIQPLVSKSKG 277
Cdd:cd13123 205 PRLDFRDPGVRRVLKLMLPALLGVSVSQInlLVDTILASFLPEGSISALYYADRLYQLPLGIFgVAIATALLPRLSRLAA 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 278 EGNYSVSRKIYRYGITAGALSAVLIYVAVFIFTDEII------GAFNPEGLEELSRCasdgLRLYFPG-FFFAGVNIITA 350
Cdd:cd13123 285 AGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVrllferGAFTAEDTLMTASA----LAAYALGlPAFALVKLLSR 360
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1199646292 351 VFFgAWDKPAPSFIISVLrGFVIIIPCAFIMSSLLGMTGVWLAFPVSELL-VLFVAVTLKIR 411
Cdd:cd13123 361 AFY-ALKDTKTPVKIAVI-AVAVNILLNLLLIKPLGHVGLALATSLSAWVnALLLLVLLRRR 420
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
57-187 |
9.99e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 37.83 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199646292 57 ASGDHKKANSVFTSCFCLASVISIILIFCGLFFSGNIARLLGANDEVYsmtlIYLKVMLLFSPLFMFNNLMTCFVRNDGA 136
Cdd:cd13124 303 AKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEGG----LILQILAPSILFLSLQQVTAAILQGLGK 378
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1199646292 137 PNLAMAAMIVGSLGNIIMDYVFIFpcKLGMFGAIAATAMAPGISLILMMFR 187
Cdd:cd13124 379 VKIPVINLLIGLLVKIVLNYVLIP--IFGIYGAAIATVIGFLVAALLNLRA 427
|
|
| |
