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Conserved domains on  [gi|1199742135|ref|WP_087471185|]
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nuclear transport factor 2 family protein [Cellulosimicrobium cellulans]

Protein Classification

COG4538 family protein( domain architecture ID 10008606)

COG4538 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SnoaL COG4538
Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];
1-110 1.52e-36

Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];


:

Pssm-ID: 443604  Cd Length: 113  Bit Score: 120.00  E-value: 1.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   1 MSTSPSAVVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIV-GRDALRAFYASRFEDT-ALHCVIDASVTFGDrWLVA 78
Cdd:COG4538     1 ATMTPEDVVQRQLDAYNARDIDAFLATYADDAEVYRFPGTLLAkGREAIRERYAERFANEpDLHAELVSRIVLGN-KVID 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1199742135  79 RELVT--TSNGTGETIATFEVRDGLITRASMVKG 110
Cdd:COG4538    80 HELVTglFGGGPVEVVAIYEVEDGLIARVWFIRG 113
 
Name Accession Description Interval E-value
SnoaL COG4538
Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];
1-110 1.52e-36

Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];


Pssm-ID: 443604  Cd Length: 113  Bit Score: 120.00  E-value: 1.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   1 MSTSPSAVVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIV-GRDALRAFYASRFEDT-ALHCVIDASVTFGDrWLVA 78
Cdd:COG4538     1 ATMTPEDVVQRQLDAYNARDIDAFLATYADDAEVYRFPGTLLAkGREAIRERYAERFANEpDLHAELVSRIVLGN-KVID 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1199742135  79 RELVT--TSNGTGETIATFEVRDGLITRASMVKG 110
Cdd:COG4538    80 HELVTglFGGGPVEVVAIYEVEDGLIARVWFIRG 113
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 9-103 4.19e-13

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 59.99  E-value: 4.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   9 VTAQVDAFNVRDLDGFCATYAPDAVVSGVAPePIVGRDALRAFYASRFE-DTALHCVIDASVTFGDRWLVARELVTTSNG 87
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPGG-PLRGRDAIRAFFAALFAaFPDLRFEIHDVIADGDRVAVRWTVTGTIPP 79

                          90       100
                  ....*....|....*....|.
gi 1199742135  88 TGET-----IATFEVRDGLIT 103
Cdd:pfam12680  80 TGRGvrvrgVDVFRFRDGKIV 100
ketosteroid_isomerase cd00781
ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond ...
 7-53 8.83e-07

ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.


Pssm-ID: 238404  Cd Length: 122  Bit Score: 43.95  E-value: 8.83e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1199742135   7 AVVTAQVDAFNVRDLDGFCATYAPDAVVSG-VAPEPIVGRDALRAFYA 53
Cdd:cd00781     7 AAVQRYVEAVNAGDPEGIVALFADDATVEDpVGSPPRSGRAAIAAFYA 54
TIGR02246 TIGR02246
conserved hypothetical protein; This family consists of uncharacterized proteins found in a ...
 7-70 4.19e-04

conserved hypothetical protein; This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.


Pssm-ID: 274053  Cd Length: 128  Bit Score: 36.97  E-value: 4.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1199742135   7 AVVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIVGRDALRAFYASRFEDTALHCVIDASVT 70
Cdd:TIGR02246   8 ALVARWEAAWAAGDAEAFADLFAPDGVFVTVPGQVRKGREAIRAAHEAFFAGPYKGTRVTGDVI 71
 
Name Accession Description Interval E-value
SnoaL COG4538
Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];
1-110 1.52e-36

Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];


Pssm-ID: 443604  Cd Length: 113  Bit Score: 120.00  E-value: 1.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   1 MSTSPSAVVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIV-GRDALRAFYASRFEDT-ALHCVIDASVTFGDrWLVA 78
Cdd:COG4538     1 ATMTPEDVVQRQLDAYNARDIDAFLATYADDAEVYRFPGTLLAkGREAIRERYAERFANEpDLHAELVSRIVLGN-KVID 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1199742135  79 RELVT--TSNGTGETIATFEVRDGLITRASMVKG 110
Cdd:COG4538    80 HELVTglFGGGPVEVVAIYEVEDGLIARVWFIRG 113
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 9-103 4.19e-13

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 59.99  E-value: 4.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   9 VTAQVDAFNVRDLDGFCATYAPDAVVSGVAPePIVGRDALRAFYASRFE-DTALHCVIDASVTFGDRWLVARELVTTSNG 87
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPGG-PLRGRDAIRAFFAALFAaFPDLRFEIHDVIADGDRVAVRWTVTGTIPP 79

                          90       100
                  ....*....|....*....|.
gi 1199742135  88 TGET-----IATFEVRDGLIT 103
Cdd:pfam12680  80 TGRGvrvrgVDVFRFRDGKIV 100
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
4-104 2.40e-11

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 56.09  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   4 SPSAVVTAQVDAFNVRDLDGFCATYAPDAVVS---GVAPEPIVGRDALRAFYASRFEDTA-LHCVIDASVTFGDRWLVAR 79
Cdd:COG3631     1 TNRELVRRFYAAFNAGDVDALLALLAEDVVWEdpgGPGAGTYRGKEAVRAFFARLAAAFEdLRFEVRRVVADGDRVVVEG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1199742135  80 ELVTTSNGTGETIAT-----FEVRDGLITR 104
Cdd:COG3631    81 TVRGTVLATGKPYENryadvFTVRDGKIVR 110
LimA COG4308
Limonene-1,2-epoxide hydrolase LimA/EphG [Secondary metabolites biosynthesis, transport and ...
 2-104 2.84e-11

Limonene-1,2-epoxide hydrolase LimA/EphG [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443449  Cd Length: 119  Bit Score: 55.68  E-value: 2.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   2 STSPSAVVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIVGRDALRAFYASRFED-TALHCVIDASVTFGDRWLVARe 80
Cdd:COG4308     1 MTSPIDVVRAFLAAWSRLDVDAALSLLADDAVYHNVPLPPVRGRDAVRAFLEGFLRGaAGFEVRIHHIAADGGTVLTER- 79

                          90       100
                  ....*....|....*....|....*...
gi 1199742135  81 LVTTSNGTGET----IATFEVRDGLITR 104
Cdd:COG4308    80 VDRFRLGGLRVefpvCGVFEVDDGKITL 107
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
7-92 1.88e-10

Ketosteroid isomerase homolog YybH [General function prediction only];


Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 53.99  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   7 AVVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIVGRDALRAFYASRFEDTALHCVIDASVTF---GDR-WLVARELV 82
Cdd:COG4319    13 ALLAAFAEAFNAGDADALAALYAEDAVFFDPGGPPVRGREAIRAAWAAAFAAGPRVTFEVEDVRVlvsGDVaVVTGRWRL 92

                          90
                  ....*....|
gi 1199742135  83 TTSNGTGETI 92
Cdd:COG4319    93 TGTDPDGEPV 102
ketosteroid_isomerase cd00781
ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond ...
 7-53 8.83e-07

ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.


Pssm-ID: 238404  Cd Length: 122  Bit Score: 43.95  E-value: 8.83e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1199742135   7 AVVTAQVDAFNVRDLDGFCATYAPDAVVSG-VAPEPIVGRDALRAFYA 53
Cdd:cd00781     7 AAVQRYVEAVNAGDPEGIVALFADDATVEDpVGSPPRSGRAAIAAFYA 54
COG5485 COG5485
Predicted ester cyclase [General function prediction only];
14-104 1.24e-06

Predicted ester cyclase [General function prediction only];


Pssm-ID: 444236 [Multi-domain]  Cd Length: 130  Bit Score: 43.69  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135  14 DAFNVRDLDGFCATYAPDAVVSGVAPEPIVGRDALRAFYASRFE---DtaLHCVIDASVTFGDrWLVARelvTTSNGT-- 88
Cdd:COG5485     8 EAWNEGDLDALDELVAPDFVYHGPLPGEPRGPEGFRAFLRGLRAafpD--LRFEIEDLIAEGD-RVAVR---WTFTGTht 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1199742135  89 GE--------------TIATFEVRDGLITR 104
Cdd:COG5485    82 GEflgipptgkrvefrGIDIYRFEDGKIVE 111
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
 8-90 4.57e-05

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 39.59  E-value: 4.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   8 VVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIVGRDALRAFYASRFEDTA-LHCVIDASVTFGDRwlVARELVTTSN 86
Cdd:pfam07366   3 VLRFYDEVWNTGDLDALDEFVAEDVVDHNPPPGVARGLDGFRAFAEMLFRAFPdLRFEVEDLVAEGDK--VAARLTFTGT 80


                  ....
gi 1199742135  87 GTGE 90
Cdd:pfam07366  81 HTGE 84
TIGR02246 TIGR02246
conserved hypothetical protein; This family consists of uncharacterized proteins found in a ...
 7-70 4.19e-04

conserved hypothetical protein; This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.


Pssm-ID: 274053  Cd Length: 128  Bit Score: 36.97  E-value: 4.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1199742135   7 AVVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIVGRDALRAFYASRFEDTALHCVIDASVT 70
Cdd:TIGR02246   8 ALVARWEAAWAAGDAEAFADLFAPDGVFVTVPGQVRKGREAIRAAHEAFFAGPYKGTRVTGDVI 71
SnoaL_4 pfam13577
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 8-99 3.00e-03

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 433323 [Multi-domain]  Cd Length: 125  Bit Score: 34.62  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199742135   8 VVTAQVDAFNVRDLDGFCATYAPDAVVSGVAPEPIVGRDALRAFYASRFEDTAL--HCVIDASVTF-GD----RWLVARE 80
Cdd:pfam13577  12 LVARYGRALDTGDWDELAALFTEDAVFDYGGLGVLEGRDAIVAGLRAALDGFLLtqHLLGNPVITVdGDtatgRAYLLAT 91

                          90
                  ....*....|....*....
gi 1199742135  81 LVTTSNGTGETIATFEVRD 99
Cdd:pfam13577  92 HVGPGDGGPEVLRGGRYED 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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