|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-451 |
1.41e-73 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 235.92 E-value: 1.41e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:cd17321 7 LAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFF 186
Cdd:cd17321 87 LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 Alrflpangpkstmprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvrrqlalpvpllpvdllr 266
Cdd:cd17321 167 A------------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 267 iPLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMAT 346
Cdd:cd17321 168 -RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 347 GLFALALLPSSPSDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAGQN 426
Cdd:cd17321 247 GLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSA 326
|
410 420
....*....|....*....|....*
gi 1200088488 427 GNHVALLTAGALATLAAIVSGLRVT 451
Cdd:cd17321 327 NLGDSGVAALLSAAAAAFAAGFHLA 351
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
27-426 |
4.55e-52 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 179.69 E-value: 4.55e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:cd17503 7 MAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFF 186
Cdd:cd17503 87 LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 AlrflpangpkstmprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvrrqlalpvPLLPVDLLR 266
Cdd:cd17503 167 A----------------------------------------------------------------------PLLDLRLFK 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 267 IPLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMAT 346
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 347 GLFALALLPSSPSDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAGQN 426
Cdd:cd17503 257 GTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQF 336
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
27-420 |
1.13e-51 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 181.42 E-value: 1.13e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:TIGR00711 13 MAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLEL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFF 186
Cdd:TIGR00711 93 MIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 ALRFLPANGPKSTMPrFDVPSAVMNALTFGLLITALS-GFAQGQ-------SMALTGIELIAllvtgfFFVRRQLALPVP 258
Cdd:TIGR00711 173 AFFILPRDKPAASEN-FDFLGLLLLSVGLGSLLYGLSeGPERGWfdsneilILSITGLVAII------AFVVWELTDDNP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 259 LLPVDLLRIPLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGA 338
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVT 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 339 VGLAVMA--TGLFALALLPSSPSdLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALV 416
Cdd:TIGR00711 326 IGLILYAvgFYWRAFTFTPDTPF-LAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404
|
....
gi 1200088488 417 ALMF 420
Cdd:TIGR00711 405 TTIL 408
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
27-410 |
2.15e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 139.72 E-value: 2.15e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:COG2814 21 LSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFF 186
Cdd:COG2814 101 LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 ALRFLPANGPKStmprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvRRQLALPVPllpvDLLR 266
Cdd:COG2814 181 LLRLLPESRPAA---------------------------------------------------RARLRGSLR----ELLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 267 IPLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMAT 346
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1200088488 347 GLFALALLPSSPSdldIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQS 410
Cdd:COG2814 286 GLLLLALAGSLWL---LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
27-415 |
6.14e-35 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 132.69 E-value: 6.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSiWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:cd17502 7 LAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFF 186
Cdd:cd17502 86 LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 alrflpangpkstmprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvrrqlalpvpllpvdllr 266
Cdd:cd17502 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 267 IPLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERI-HAGLLGAVGLAVMA 345
Cdd:cd17502 166 LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTgRYKPLIVIGTILMS 245
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 346 TGLFALALLPSSPSDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAAL 415
Cdd:cd17502 246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
38-419 |
4.63e-30 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 119.99 E-value: 4.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 38 ALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFG 117
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 118 GAALmSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFalrflpangpk 197
Cdd:cd17504 98 GAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL----------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 198 stmprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvrrqlalpVPLLPVDLLRIP-LFSLSICT 276
Cdd:cd17504 166 -----------------------------------------------------------VPLIDLRLLRRRnVLLANITA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 277 SICSFCAQMLALVsLPFFLQS----VVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALA 352
Cdd:cd17504 187 LLAGFGMFMVFQL-LPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA 265
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1200088488 353 LLPSSPsdLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALM 419
Cdd:cd17504 266 LLHSSL--WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-274 |
1.44e-28 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 114.14 E-value: 1.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 6 SDGLPLPLRYGAIATIIIGISMAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQ 85
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 86 CGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILS 165
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 166 VASWQWLFAINVPLGIVAIFFALRFLPANGPKSTMPRFDVPSAVMNALTFGLLITALSGFAQGQSMALTGIELIALLVTG 245
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260
....*....|....*....|....*....
gi 1200088488 246 FFFVRRQLALPVPLLPVDLLRIPLFSLSI 274
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLL 272
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
30-419 |
3.76e-27 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 113.67 E-value: 3.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 30 LDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTL 109
Cdd:PRK14995 20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 110 ARIAQGFGGAALMSVNTALIRLIFPQ-RHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFAL 188
Cdd:PRK14995 100 TRALLAIGAAMIVPATLAGIRATFTEeKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 189 RFLPANGPKSTMPrFDVPSAVMNALTFGLLI----TALSGFAQGQSMALTGIELIALLvtgFFFVRRQLALPVPLLPVDL 264
Cdd:PRK14995 180 RYVPRQAGRRDQP-LNLGHALMLIVAILLLVysakTALKGFLSLWVTSLTLLTGALLL---GLFIRTQLAASRPMIDMRL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 265 LRIPLFSLSICTSICSfcaqMLALVSLPFF----LQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVG 340
Cdd:PRK14995 256 FTHRIILSGVVMAMTA----MITLVGFELLmaqeLQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGG 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1200088488 341 LAVMATGLFALALLPSSPSDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALM 419
Cdd:PRK14995 332 MALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLL 410
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
27-320 |
7.77e-27 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 112.52 E-value: 7.77e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:PRK10504 21 MQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFF 186
Cdd:PRK10504 101 LLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 ALRFLpangPKSTMP--RFDVPSAVMNALTFGLLITALSGfaqGQSMALTGIELIALLVTG----FFFVRRQLALPVPLL 260
Cdd:PRK10504 181 TLMLM----PNYTMQtrRFDLSGFLLLAVGMATLTLALDG---SKGLGLSPLAIAGLVAVGvvalLLYLLHARNNNRALF 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 261 PVDLLRIPLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVM 320
Cdd:PRK10504 254 SLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGM 313
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
38-421 |
5.92e-25 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 105.74 E-value: 5.92e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 38 ALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFG 117
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 118 GAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPangpk 197
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 198 STMPRFDvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvRRQLALPVPLLPVDLLRIPLFSLSICTS 277
Cdd:cd17320 176 ETLPEEK---------------------------------------------RKPLLSSLLRAYKRVLKNRRFLGYALAL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 278 ICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAG--LLGAVGLAVMATGLFALALLP 355
Cdd:cd17320 211 GLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRrlLRLGLLLLLAAALVLLLAALL 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 356 SSPSDLDIVWRMILCGAGFGlFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFN 421
Cdd:cd17320 291 GGLSLWPLVAPLFLIFFGFG-LIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN 355
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-413 |
1.62e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.04 E-value: 1.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALP-TIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLH 105
Cdd:pfam07690 7 LAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 106 TLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIF 185
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 186 FALRFLPANGPKstmprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfFFVRRQLALPVPLLPVDLL 265
Cdd:pfam07690 167 LLLLPRPPPESK-------------------------------------------------RPKPAEEARLSLIVAWKAL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 266 RIPLFSLSICTSICSFCAQMLALVSLPFFlQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMA 345
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1200088488 346 TGLFALALLPSSPSDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGA 413
Cdd:pfam07690 277 LAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-427 |
5.30e-24 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 103.03 E-value: 5.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:cd17474 10 LAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPtIAAAILSVASWQWLFAINVPLGIVAIFF 186
Cdd:cd17474 90 LLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGP-LLGGLLAAISWRYPFFLLAALIPVAFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 ALRFLPANGPKSTMPRFDVPSAVMNaltfgllitalsgfaqgqsmALTGIELIALLVTGFFFVrrqlalpvpllpvdllr 266
Cdd:cd17474 169 ILFLLPEPKEKAKSSSATKLRDLKK--------------------ALRGRGLLTFLVSAFLYF----------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 267 IPLFSLsictsicsfcaqmlaLVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIE-RIHAGLLGAVGLAVMA 345
Cdd:cd17474 212 FLYFAF---------------LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 346 TGLFALALLPSSPSDLDIVwrmILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAGQ 425
Cdd:cd17474 277 LSLLLLGFVPSLALLLIAI---VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGL 353
|
..
gi 1200088488 426 NG 427
Cdd:cd17474 354 SA 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
39-424 |
7.41e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 102.65 E-value: 7.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 39 LPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGG 118
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 119 AALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPANGPKS 198
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 199 TMprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvRRQLALPVPLLPVDLLRIPLFSLSICTSI 278
Cdd:cd17325 179 NK-------------------------------------------------RAVSAARLRSGLRLLLRDRRLLALFLAIF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 279 CSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMAtglFALALLPSSP 358
Cdd:cd17325 210 VLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA---VALLLLPLAT 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 359 SDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:cd17325 287 SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-424 |
4.04e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 97.23 E-value: 4.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 39 LPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGG 118
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 119 AALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPANGPKS 198
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 199 TMPrfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvrrqlaLPVPLLPVDLLRIPLFSLSICTSI 278
Cdd:cd17324 182 PGS-----------------------------------------------------LGLLSSLLLLLRNPRLRLAYLITF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 279 CSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGlfaLALLPSSP 358
Cdd:cd17324 209 LLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL---LLLTLLGP 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 359 SDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRsGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:cd17324 286 SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG 350
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-424 |
7.38e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 96.48 E-value: 7.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 7 DGLPLPLRYGAIATIIIGISMAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQC 86
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 87 GLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSV 166
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 167 ASWQWLFAINVPLGIVAIFFALRFLpangpkstmprfdvpsavmnaltfgllitalsgfaqgqsmaltgieliallvtgf 246
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLL------------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 247 ffvrrqlalpvpllpvdllriplfslsICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGY 326
Cdd:COG2271 186 ---------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGW 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 327 LIERIHAG--LLGAVGLAVMATGLFALALLPSSPSdldIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTA 404
Cdd:COG2271 239 LSDRLGRRrkLVLAIGLLLAALALLLLALLPSPAL---AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTF 315
|
410 420
....*....|....*....|
gi 1200088488 405 RLLGQSSGAALVALMFNLAG 424
Cdd:COG2271 316 GFLGGALGPLLVGYLLDATG 335
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
35-414 |
4.05e-18 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 86.53 E-value: 4.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 35 ANVALPTIASDLQASPASsIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQ 114
Cdd:cd06179 17 PAAVLPFIVADLGPSSNS-TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 115 GFGGAALMSVNtALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAIL--SVASWQWLFAINVPL------GIVAIFF 186
Cdd:cd06179 96 GIGAGTQGLGA-AVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAIFnalaliLLFFFYH 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 187 ALRFLPANGPKST--MPRFDVPSAVMNALTFGLLITALSgfAQGQSMALTGIELIALLVTGF-----FFVRRQLALPVPL 259
Cdd:cd06179 175 PPPRPQLHGSSTRqkLKRLDWVGLFLLIAGLVLFLLGLS--WGGNPYPWSSAHVIAPLVIGGvlliaFGLYEWKGTKDGL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 260 L-PVDLLRIPLFSLSIctsICSFCAQML---ALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERI-HAG 334
Cdd:cd06179 253 LpPRLLFRGRNFALIL---IVAFVEGMIfysLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIkHIK 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 335 LLGAVGLAVMATGLFALALlpSSPSDLDIVWRMI-LCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGA 413
Cdd:cd06179 330 WQLVAGFVLFTAFLALLAL--ITPDNKALAIAFSvLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGT 407
|
.
gi 1200088488 414 A 414
Cdd:cd06179 408 A 408
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
26-424 |
2.83e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 83.01 E-value: 2.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 26 SMAVLDGAIANVALPTIASDLQASPASSI-WIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSL 104
Cdd:cd17473 9 TLTVMAGAAIAPALPAIAQHFVPNSELLVpLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 105 HTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVaSWQWLFAINVpLGIVAI 184
Cdd:cd17473 89 YALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYL-LALPVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 185 FFALRFLPANGPKSTMPRFDVPSAVMNALTFGLLITALSGFaqgqsmaltgieliaLLVTGFFFVrrqlalpvpllpvdl 264
Cdd:cd17473 167 ILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAF---------------LAMLLFYVI--------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 265 lriplfslsictsicsfcaqmlaLVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVM 344
Cdd:cd17473 217 -----------------------PIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALM 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 345 ATGLFALALLPSSPSdldIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:cd17473 274 ALGFLLLALASGLWV---VLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
37-424 |
1.31e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.38 E-value: 1.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 37 VALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGF 116
Cdd:COG2223 26 VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 117 GGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPAngp 196
Cdd:COG2223 106 GGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRD--- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 197 kstmprfdvPSAVMNALTFGLLITALSGFAQGQSMALTGIeliallvtgfffvrrqlalpvpllpvdllriplfslsict 276
Cdd:COG2223 183 ---------PPAGAAAAAKASLRDQLEALRDPRFWLLSLL---------------------------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 277 SICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALALLPS 356
Cdd:COG2223 214 YFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1200088488 357 SPSDLdiVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:COG2223 294 SLWLF--LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
34-424 |
1.99e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.63 E-value: 1.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 34 IANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIA 113
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 114 QGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPA 193
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 194 NGPKSTMPRfdvpsavmnaltfgllitalsgfaqgqsmaltgieliaLLVTGFFFVRRQLALPVPLLpvdllripLFSLS 273
Cdd:cd17489 174 PPVAAEEAE--------------------------------------AGTRAFRRLVEKKVLPPALI--------LFLAS 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 274 IC-TSICSFcaqmlalvsLPFFLQSvvgRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALA 352
Cdd:cd17489 208 IAyGAISTF---------LPLYAAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1200088488 353 LLPSSPSdldIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:cd17489 276 FAGSPWM---LLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
38-197 |
4.43e-15 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 76.49 E-value: 4.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 38 ALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFG 117
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 118 GAALMSVNTALIRLIFPQRHLGRGMginSFIVAVSSAA---GPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPAN 194
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMM---SFVTLVMTIApllAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
...
gi 1200088488 195 GPK 197
Cdd:PRK11102 170 LPK 172
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
32-192 |
5.25e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 76.07 E-value: 5.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 32 GAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLAR 111
Cdd:cd17323 15 SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 112 IAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFL 191
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL 174
|
.
gi 1200088488 192 P 192
Cdd:cd17323 175 P 175
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-428 |
1.56e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 71.69 E-value: 1.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 30 LDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTL 109
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 110 ARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILS--VASWQWLFAINVPLGIVAIFFA 187
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 188 LRFLPANGPKSTMPRFDVPSAvmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvrrqlalPVPLLPVDLLRI 267
Cdd:cd06174 170 LLVVPDPPESARAKNEEASSK-----------------------------------------------SVLKLLKRVLKN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 268 PLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGL-LGAVGLAVMAT 346
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMAL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 347 GLFALALLPSSPSdldIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAGQN 426
Cdd:cd06174 283 GLALLLLAPSLLL---LLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
|
..
gi 1200088488 427 GN 428
Cdd:cd06174 360 TG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-192 |
7.10e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 69.52 E-value: 7.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 30 LDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTL 109
Cdd:cd17319 17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 110 ARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALR 189
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF 176
|
...
gi 1200088488 190 FLP 192
Cdd:cd17319 177 YLR 179
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
73-192 |
7.12e-13 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 65.75 E-value: 7.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 73 FLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVS 152
Cdd:TIGR00880 20 LLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1200088488 153 SAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLP 192
Cdd:TIGR00880 100 PLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
27-186 |
1.80e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.30 E-value: 1.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDG---AIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDS 103
Cdd:cd17365 7 IIVLDGfdlAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 104 LHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAIN-VPLGIV 182
Cdd:cd17365 87 VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGgVPPLIL 166
|
....
gi 1200088488 183 AIFF 186
Cdd:cd17365 167 LPLL 170
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
37-193 |
2.18e-10 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 61.89 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 37 VALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGF 116
Cdd:cd17476 19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 117 GGAALMSVNTALIRLIFPQrHLGRGMGINSFIVA--VSSAAGPTIAAAILSVASWQWLF----AINVPLGIVAIFFALRF 190
Cdd:cd17476 99 GPAFLLPNAMALLGRTYPP-GPRKNIVFSLFGATapLGFALGGVFGGLFAQLAWWPWIFwflaILAAIVAVAAIFWTSPS 177
|
...
gi 1200088488 191 LPA 193
Cdd:cd17476 178 FIA 180
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
30-192 |
1.93e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.29 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 30 LDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTL 109
Cdd:TIGR00895 31 YDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 110 ARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALR 189
Cdd:TIGR00895 111 LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMR 190
|
...
gi 1200088488 190 FLP 192
Cdd:TIGR00895 191 FLP 193
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
34-424 |
7.21e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.24 E-value: 7.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 34 IANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARI- 112
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLl 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 113 ----AQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVpLGIVAIFFAL 188
Cdd:cd06173 97 vlafLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 189 RFLPANGPKSTMPRfdvpsavmnaltfgllitalsgfaqgqsmaltGIELIALLVTGFFFVRRQlalpvpllpvdllriP 268
Cdd:cd06173 176 LFIRRPPPAAPGES--------------------------------SSLLLRDLREGLRYLRRS---------------P 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 269 LFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGL 348
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 349 FALALLPSSPsdLDIVWrMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:cd06173 289 LVLGLSPSLW--LLLAA-LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-192 |
7.58e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 7.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 49 SPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRR--VYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNT 126
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 127 ALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLP 192
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
39-457 |
1.09e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.72 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 39 LPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGG 118
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 119 AALMSVNTALIRLIFPQRhLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPANGPKS 198
Cdd:COG2807 121 AVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 199 tmprfdvPSAVMNALTFGLLITALsgfaqgqsmaltgieliALLVTGFFFVrrqlalpvpllpvdllriplfslsictsi 278
Cdd:COG2807 200 -------AAAPAAASLRSLWRSPL-----------------AWLLTLFFGL----------------------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 279 csFCAQMLALVS-LPFFLQSvVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHA-GLLGAVGLAVMATGLFALALLPS 356
Cdd:COG2807 227 --QSLLYYAVVAwLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDrRPLLLLLGLLGLAGLLGLLLAPG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 357 SpsdLDIVWrMILCGAGFGLFQSPNNHTIITSAPRHRSGGA-SGMLGTARLLGQSSGAALVALmfnLAGQNGNHVALLTA 435
Cdd:COG2807 304 S---LPWLW-AVLLGLGQGGLFPLALTLIGLRARTPAEAAAlSGMAQSVGYLLAALGPLLVGA---LHDATGSWTAALLL 376
|
410 420
....*....|....*....|..
gi 1200088488 436 GALATLAAIVSGLRVTQPRVQA 457
Cdd:COG2807 377 LAALAVLMLVAGLLAGRPYVED 398
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
30-192 |
1.76e-07 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 53.11 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 30 LDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTL 109
Cdd:TIGR00893 8 LDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 110 ARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALR 189
Cdd:TIGR00893 88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLK 167
|
...
gi 1200088488 190 FLP 192
Cdd:TIGR00893 168 FIP 170
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-406 |
3.50e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.16 E-value: 3.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 33 AIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARI 112
Cdd:COG0738 25 ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 113 AQGFGGAALMSVNTALIRLIFPQRHlGRGMGINSFIVAVSSAAGPTIAAAILSV---ASWQWLFAIN-VPLGIVAIFFAL 188
Cdd:COG0738 105 LLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILaVLLLLLALLFLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 189 RFLPANGPKSTMPRFDVPSavmnaltfgllitalsgfaqgqsmaltgieliallvtgfffvrrqlalpvpllPVDLLRIP 268
Cdd:COG0738 184 SKLPEIEEEEEEAAGSAAS-----------------------------------------------------LKSLLKNP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 269 LFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGL 348
Cdd:COG0738 211 RLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1200088488 349 FALALLPSSPSdldIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARL 406
Cdd:COG0738 291 LLALLAPGPWL---ALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIV 345
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
212-428 |
3.80e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 3.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 212 ALTFGLLITALSGFAQGQ---SMALTGIELIALLVTGFFFVRRQLALPVPLLPV-----DLLRIPLFSLSICTSICSFCA 283
Cdd:COG2211 164 SVLPPPLVAAFGGDAALGyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFFLA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 284 QMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALALLPSSPSDLDI 363
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1200088488 364 VWrMILCGAGFGLFQsPNNHTIITSAP--------RHRSGGASGMLGTARLLGQSSGAALVALMFNLAGQNGN 428
Cdd:COG2211 324 VL-AALAGIGLGAIL-VLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG 394
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
27-228 |
4.26e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.92 E-value: 4.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 27 MAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHT 106
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 107 LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVAS----WQWLFAINVPLGIV 182
Cdd:cd17371 90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLFLLGALPALL 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1200088488 183 AIFFAL------RFLPANGPKSTMPRFDVPSAVMNALTFG--LLITALSGFAQG 228
Cdd:cd17371 170 VLFIRRfvkeppQWQAARAARRHFADRPSLRELFSPPLLRttLLASLLATGALG 223
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-191 |
7.73e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.06 E-value: 7.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 31 DGAIANVALPTIAS--DLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLT 108
Cdd:cd17316 14 DFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 109 LARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVAS----WQWLFAINVPLGIVAI 184
Cdd:cd17316 94 VLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLAL 173
|
....*..
gi 1200088488 185 FFALRFL 191
Cdd:cd17316 174 LLRRRTL 180
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
71-194 |
1.24e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 50.29 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 71 FSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGgaALMSVNTALIRLIFPQRHLGRGMGINSFIVA 150
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLADLTREENRTKAMALIGASIG 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1200088488 151 VSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPAN 194
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDP 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
43-188 |
1.62e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 43 ASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALM 122
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 123 SVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFAL 188
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
37-223 |
1.72e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 50.02 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 37 VALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGF 116
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 117 GGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPANGP 196
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETRP 183
|
170 180 190
....*....|....*....|....*....|..
gi 1200088488 197 KSTMPRFDVPSAVMNALTFG-----LLITALS 223
Cdd:PRK10473 184 ARAPAASSKPRENSESLLNRfflsrLVITTLS 215
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
78-225 |
1.98e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.86 E-value: 1.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 78 FGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGP 157
Cdd:cd17477 58 VGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGP 137
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1200088488 158 TIAAAIlSVASWQ--WLFAINVPLGIVAIFFALRFLPANGPKSTMPRFDV----PSAVMNALTFGLLITALSGF 225
Cdd:cd17477 138 LLLALV-GTAGALpfLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLlriaPLALLGAFVAGFLEGAFYSL 210
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
74-359 |
2.25e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 49.55 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 74 LGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSS 153
Cdd:PRK15402 71 LSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAP 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 154 AAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPANgpkSTMPRFDVPSAVMNAlTFGLLITALSGFAQGQSMAL 233
Cdd:PRK15402 151 LLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPET---AGRVGEKLSLKELGR-DYKLVLKNRRFVAGALALGL 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 234 TGIELIA-------LLVTGFFFVRRQLAlpvpllpvdLLRIPLFslsictsicsfcaqmLALVSLPFFLQSVVGRSEVET 306
Cdd:PRK15402 227 VSLPLLAwialspvILISGEQLSSYEYG---------LLQVPVF---------------GALIAGNLTLARLTSRRPLRS 282
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1200088488 307 GLLLTPWP----LATMVMAPL-AGYLIERIHAGL-LGAVGLAVMATGLFALALLPSSPS 359
Cdd:PRK15402 283 LIRMGLWPmvagLLLAALATViSSHAYLWLTAGLsLYAFGIGLANAGLYRLTLFSSDVS 341
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
36-191 |
2.82e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.19 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 36 NVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQG 115
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 116 FGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFL 191
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL 178
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-192 |
2.95e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.16 E-value: 2.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 30 LDGAIANVALPTIASDLQASPASSIWIVNAYqiAIVISLLS--FSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTL 107
Cdd:cd17328 13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVF--IISYMVLSpiFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 108 TLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSA----AGPTIAAAILsvaSWQWLFAINVPLGIVA 183
Cdd:cd17328 91 LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGlgyvVGGLVAQATG---GWRWAFRVTGVLGVLL 167
|
....*....
gi 1200088488 184 IFFALRFLP 192
Cdd:cd17328 168 AILLLLFVR 176
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
52-414 |
4.91e-06 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 48.84 E-value: 4.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 52 SSIWIVNAyqIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRL 131
Cdd:cd17322 40 STINVVNN--IVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILAD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 132 IFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQW---LFAINVPLGIVAIFFALRFLPANGPKSTMPR------ 202
Cdd:cd17322 118 FSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWgygMWAIILPLSSLPLVLCLLYMQRKARKDGEIKelknqe 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 203 ------------------FDVPSAVMNALTFGLLITALSgFAQGQSMALTGIELIALLVTGF----FFVRRQLAL-PVPL 259
Cdd:cd17322 198 teeqtgglsqnlvklfwkLDIFGVILLTAGLGLILVPLT-LAGGAKSKWKNSSIIAMIVLGGvllvAFLLWEAKFaKYPF 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 260 LPVDLLRIPLFSLSICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIH---AGLL 336
Cdd:cd17322 277 LPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrykVLVI 356
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1200088488 337 GAVGLAVMATGLFALALLPSSpSDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAA 414
Cdd:cd17322 357 IGVPLYIVGMGLLIRYRGGSG-SHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAA 433
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
74-192 |
5.62e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 48.28 E-value: 5.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 74 LGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSS 153
Cdd:PRK15403 74 LSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAP 153
|
90 100 110
....*....|....*....|....*....|....*....
gi 1200088488 154 AAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLP 192
Cdd:PRK15403 154 IIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMP 192
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
65-191 |
1.09e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.26 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 65 VISLLSFSFLG---DMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRG 141
Cdd:cd17391 251 VSSLLSAPRLGklgDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRI 330
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1200088488 142 MGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFL 191
Cdd:cd17391 331 FGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
32-188 |
1.74e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 32 GAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALS--DSLHTLTL 109
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLV 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 110 ARIAQGFGGAALMSVNTALI-------RLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVA--------SWQWLFA 174
Cdd:COG2211 325 LAALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqSPSALTG 404
|
170
....*....|....
gi 1200088488 175 INVPLGIVAIFFAL 188
Cdd:COG2211 405 IRLLFFLLPAVLLL 418
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
31-186 |
2.71e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 46.02 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 31 DGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLA 110
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 111 RIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIV--------AVSSAAGPTIAAAILSVASWQWLFAINVplgIV 182
Cdd:cd17359 96 RIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIvfgqllayIVNYLIANAGGADWLGAEGWRWMLGLEA---IP 172
|
....
gi 1200088488 183 AIFF 186
Cdd:cd17359 173 AILF 176
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
32-190 |
7.80e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 7.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 32 GAIANVALPTIASD-LQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLA 110
Cdd:cd06173 224 GGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAA 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 111 RIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRF 190
Cdd:cd06173 304 LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
26-192 |
2.58e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 26 SMAVLDGAIANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLH 105
Cdd:pfam00083 21 AFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKW 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 106 T---LTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAI-LSVASWQW--LFAINVPL 179
Cdd:pfam00083 101 SvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLnKTSNSDGWriPLGLQLVP 180
|
170
....*....|...
gi 1200088488 180 GIVAIFFALrFLP 192
Cdd:pfam00083 181 ALLLIIGLL-FLP 192
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
40-191 |
3.39e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 40 PTIASDLQASPASSIWIVNAYQI-AIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGG 118
Cdd:cd17490 219 PLIAKQLGASSFQLGLLSIIYLLpNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGT 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1200088488 119 AALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFL 191
Cdd:cd17490 299 GILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
37-190 |
4.30e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 37 VALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSL-HTLTLARIAQG 115
Cdd:cd17355 231 VHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPpLALLLFAALFG 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1200088488 116 FGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVA-SWQWLFAINVPLGIVAIFFALRF 190
Cdd:cd17355 311 LGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVLPI 386
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
38-224 |
4.42e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 42.38 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 38 ALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFG 117
Cdd:PRK03893 42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 118 GAALMSVNTALIRLIFPQRHLGRGMG--INSFIVAVSSAAgpTIAAAILSVASWQWLFAInvplGIVAIFFAL---RFLP 192
Cdd:PRK03893 122 MAGEYGSSATYVIESWPKHLRNKASGflISGFSIGAVVAA--QVYSLVVPVWGWRALFFI----GILPIIFALwlrKNLP 195
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1200088488 193 ----------ANGPKSTM------PRFDVPSAVMNALTFGLLITALSG 224
Cdd:PRK03893 196 eaedwkekhaGKAPVRTMvdilyrGEHRIINILLTLAAAAALWFCFAG 243
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
37-408 |
5.08e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 5.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 37 VALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGF 116
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 117 GGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAInvpLGIVAIFFalrflpangp 196
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV---AGLVSILA---------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 197 kstmprfdvpsavmnALTFGLLITALSGFAQGQSMALTgieliallvtgfffvrRQLALPVPLLPVDLLRIPLFSLSICt 276
Cdd:cd17475 164 ---------------AVLFWLFYREPPAASAATESAST----------------LLRSLKEVLRNRDVWLIAIAGALLV- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 277 sicsfCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAG-----LLGAVGLAVMAtgLFAL 351
Cdd:cd17475 212 -----APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGrrrpvLVITAAIAAAA--LLVL 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1200088488 352 ALLPSSPSDLDIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLG 408
Cdd:cd17475 285 SLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIG 341
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
294-422 |
5.58e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 5.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 294 FLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALALLPSSPsdLDIVWRMILcGAG 373
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--LLLLALFLL-GLG 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1200088488 374 FGLFQSPNNhTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNL 422
Cdd:COG0738 110 LGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILL 157
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
38-193 |
6.57e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 41.80 E-value: 6.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 38 ALPTIASDLQASPAssiwivnayQIAIVIS--LLSFSF-------LGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLT 108
Cdd:PRK11043 28 AFKAIQADLQTSAS---------AVSASLSlfLAGFALgqllwgpLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 109 LARIAQGFGGAALMSVNTALIRLIFPQrhlGRGMGINSFI---VAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIF 185
Cdd:PRK11043 99 VLRFVQAVGVCSAAVIWQALVIDRYPA---QKANRVFATImplVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLIL 175
|
....*...
gi 1200088488 186 FALRFLPA 193
Cdd:PRK11043 176 PTLRLKPS 183
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
42-188 |
8.17e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 8.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 42 IASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMF-GHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAA 120
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1200088488 121 LMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILS-VASWQWLFAINVPLGIVAIFFAL 188
Cdd:cd06174 310 LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
53-193 |
8.47e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.44 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 53 SIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCAL--SDSLHTLTLARIAQGFGGAALMSVNTALI- 129
Cdd:cd17332 258 LVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlpPGNLVLILVLAVLAGIGYGGANLLPWAMLa 337
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 130 ------RLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPA 193
Cdd:cd17332 338 dvidygELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVLPA 407
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-427 |
8.78e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 41.59 E-value: 8.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 36 NVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQG 115
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 116 FGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVA-SWQWLFAINVPLGIVAIFFALRFLPAN 194
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 195 GPKSTMPRFD---VPSAVMNALTFGLLITALSGFAQgqsmALTGIELIALLVTGFFFVrrqlalpvpllpvdllripLFS 271
Cdd:TIGR00881 175 PQSCGLPPAEempNEEPDGDAEKKEEELTKKQIFLQ----YVLLNKVLWYISLGYVFV-------------------YVV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 272 LSICTSIcsfcaqmlalvsLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFAL 351
Cdd:TIGR00881 232 RTGILDW------------SPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1200088488 352 ALLPSSPSDLDIVWRMILCGAGFGLFQSPNNHTIITS--APRHRSGGASGMLGTARLLGQSSGAALVALMFNLAGQNG 427
Cdd:TIGR00881 300 LVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASelAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAG 377
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
64-190 |
1.15e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 64 IVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMG 143
Cdd:cd17474 248 ALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1200088488 144 INSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRF 190
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
274-424 |
1.20e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 274 ICTSICSFCAQMLALVSLPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALAL 353
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1200088488 354 LPSSPSdldIVWRMILCGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:pfam07690 82 ASSLWL---LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-189 |
1.27e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 62 IAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFPQRHLGRG 141
Cdd:cd17330 222 AGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKA 301
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1200088488 142 MGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALR 189
Cdd:cd17330 302 QGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-280 |
2.19e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 55 WIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFP 134
Cdd:cd17329 39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 135 QRHLGRGMGINSFIVAVSSAAGPtIAAAILSVASWQWLFAINVPLGIVAIFFALRFLPANGPKSTMPRF-DVPSAVMNAL 213
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGP-LLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKtEILRGYKIVL 197
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1200088488 214 TFGLLItalsgfaqgqsmaltgieLIALLVTGFFFVRRQLALPVPLLPVDLLRIPLFSLSICTSICS 280
Cdd:cd17329 198 RDRAFL------------------LFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNA 246
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
55-194 |
3.22e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.54 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 55 WIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVNTALIRLIFP 134
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1200088488 135 QRHLGRGMGINSFIVAVSSAAGPTIAAAIL------SVASWQWLFAINvplGIVAIFFAL---RFLPAN 194
Cdd:cd17327 125 REEQAKRIAFFYAAAGLGSIFGGLLAYGVFkilgvgGLAGWRWLFIIE---GLITIIIGLvifFWLPDN 190
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
46-155 |
3.37e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 46 LQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALMSVN 125
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
|
90 100 110
....*....|....*....|....*....|
gi 1200088488 126 TALIRLIFPQRHLGRGMGINSFIVAVSSAA 155
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
280-424 |
3.63e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 280 SFCAQMLALVSLPFFLQSVVGrSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALALLPSSPs 359
Cdd:cd17489 8 FFLSFYLLLPVLPLYAHDLGG-SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA- 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1200088488 360 dLDIVWRMILcGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:cd17489 86 -LLLVLRLIH-GIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG 148
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-192 |
3.72e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 43 ASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARIAQGFGGAALm 122
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV- 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 123 SVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAIFFALRFLP 192
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
31-192 |
3.83e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.48 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 31 DGAIANVALPTIASDLQASPASSI--WIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLT 108
Cdd:cd17315 12 DLGVINGALLYIAKDLGFGLSTSLqgLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 109 LARIAQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAV----SSAAGptIAAAILSVASWQWLFAINVPLGiVAI 184
Cdd:cd17315 92 VGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFgillAYLLG--LALSLSPPGWWRLMFALAAVPA-LLQ 168
|
....*...
gi 1200088488 185 FFALRFLP 192
Cdd:cd17315 169 LLLMFFLP 176
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
34-215 |
4.62e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 39.35 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 34 IANVALPTIASDLQASPASSIWIVNAYQIAIVISLLSFSFLGDMFGHRRVYQCGLVVFTFTSLLCALSDSLHTLTLARI- 112
Cdd:pfam05977 28 MQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLSPWLLl 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 113 ----AQGFGGAALMSVNTALIRLIFPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVpLGIVAIFFAL 188
Cdd:pfam05977 108 gltfLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNA-LSYFAVIAAL 186
|
170 180
....*....|....*....|....*..
gi 1200088488 189 RFLPANGPKSTMPRFDVPSAVMNALTF 215
Cdd:pfam05977 187 WRWKRAAPASPLPRERIFGAVRAGLRF 213
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
266-424 |
4.74e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 4.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 266 RIPLFSLSICTSICSFCAQMLALVSLPFfLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMA 345
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1200088488 346 TGLFALALLPSSPsdLDIVWRMILcGAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:COG2814 87 LGSLLCALAPSLW--LLLAARFLQ-GLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
291-424 |
7.17e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.37 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 291 LPFFLQSVVGRSEVETGLLLTPWPLATMVMAPLAGYLIERIHAGLLGAVGLAVMATGLFALALLPSSPSdldIVWRMILC 370
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV---LLVLLFLV 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1200088488 371 GAGFGLFQSPNNHTIITSAPRHRSGGASGMLGTARLLGQSSGAALVALMFNLAG 424
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG 148
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
38-184 |
8.60e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 38.49 E-value: 8.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200088488 38 ALPTIASDLQASPASSIWiVNAYQIAIVISLLSFSFLGDMFGHR----RVYQCGLVVFTFTSLLCALSDSLHTLTLARIA 113
Cdd:pfam06609 66 ALPNILQDIGQSENQGLF-STLWTMGQAVSILMMGRLTDRFGRRpfviATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA 144
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1200088488 114 QGFGGAA------LMSVNTALIrlifpqrhlgrGMGINSFIVAVSSAAGPTIAAAILSVASWQWLFAINVPLGIVAI 184
Cdd:pfam06609 145 AGPAGASplfigeLMSNKTKFL-----------GLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAV 210
|
|
| |
