|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-415 |
3.41e-85 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 264.43 E-value: 3.41e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 13 SWRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGL 92
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 93 VSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLH 172
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL------LF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 173 GWQWLFAVEGLMATAVGIWAYWYLdnrpadakwlsvaerrqiqdlldredqhktshgrslltvlcqPSVLYLCLVYMLIQ 252
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL------------------------------------------RQVWGLALGYFGIN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 253 ASVYGVVFYLPTQVGGLLGTRVgLMVGLVSAIPWVCALFAAWWIPGYSDR--TGERRKTASLTLLMAAAGIACSVTFANP 330
Cdd:cd17319 193 YALYGLLTWLPTYLKQARGFSL-KQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 331 LLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVA 410
Cdd:cd17319 272 VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLA 351
|
....*
gi 1204946024 411 ALLVL 415
Cdd:cd17319 352 ALLVL 356
|
|
| HpaX |
TIGR02332 |
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily ... |
8-415 |
2.46e-84 |
|
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily (pfam07690). Member of this family are found in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterized by Prieto, et al. ( as 4-hydroxyphenylacetate permease in E. coli, where 3-HPA and 3,4-dihydroxyphenylacetate are shown to competitively inhibit 4-HPA transport and therefore also interact specificially.
Pssm-ID: 131385 [Multi-domain] Cd Length: 412 Bit Score: 264.16 E-value: 2.46e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 8 LLAKISWRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIM 87
Cdd:TIGR02332 1 VIKKLFRRLIIFLFILFIFSFLDRINIGFAGLTMGKDLGLSATMFGLAATLFYAAYVICGIPSNIMLAIIGARRWIAGIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 88 VSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDG 167
Cdd:TIGR02332 81 VLWGIASTATMFATGPESLYLLRILVGIAEAGFLPGILLYLTFWFPAYFRARANALFMIAMPVTMALGLILSGYILALDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 168 FSGLHGWQWLFAVEGLMATAVGIWAYWYLDNRPADAKWLSVAERRQIQDLLDRED----------QHKTSHGRSLLTVLC 237
Cdd:TIGR02332 161 LMALKGWQWLFLLEGFPSVILGVMTWFWLDDSPDKAKWLDEEDKKALKEMIDNDQltleqpegafAHAAMPQRSMLREIF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 238 QPSVLYLCLVYMLIQASVYGVVFYLPTQVGGLLGTRVGLMVGLVSAIPWVCALFAAWWIPGYSDRTGERRKTASLTLLMA 317
Cdd:TIGR02332 241 TPAIMLYTLAYFCLTNTLSAINIWTPQILQSFNQGSSNIMIGLLAAIPQFCTIFGMIWWSRHSDRLKERKHHTALPYLFA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 318 AAGIACSVTFANPLLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPA 397
Cdd:TIGR02332 321 AAGWLLASATDHNLIQLLGIIMASMGSFSAMAIFWTTPDQSISLQARAIAIAVINATGNIGSALSPFLIGILKDATGSFN 400
|
410
....*....|....*...
gi 1204946024 398 AGLYLlsattvVAALLVL 415
Cdd:TIGR02332 401 SGLWF------VAALLVI 412
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
11-354 |
8.64e-59 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 197.47 E-value: 8.64e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 11 KISWRLLPFLLLMYIMAFLDRANVGFAK-QAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVS 89
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 90 WGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDGFS 169
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 170 GLHGWQWLFAVEGLMATAVGIWAYWYLDNRPADAKWLSVAERRQIQDLLDREDQHKTSHGRSL---LTVLCQPSVLYLCL 246
Cdd:cd17327 161 GLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWkqiKEAFKDPRTWLLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 247 VYMLIQASVYGVVFYLPTQVGGLLGTrvGLMVGLVSAIPW----VCALFAAWWipgySDRTGERRKTASLTLLMAAAGIA 322
Cdd:cd17327 241 FFFCSQITNNGISNFLPLILKSLGFY--SLQTNLLSVPIGalgaVSLLIAALL----SDRFKKRGLFAIFACVLALVGSI 314
|
330 340 350
....*....|....*....|....*....|..
gi 1204946024 323 CSVTFANPLLGMLALCFAASGFIAVQPVFWTF 354
Cdd:cd17327 315 ILLAAPNPPGAYFAAYILGGGSYAGFPILLSW 346
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
22-415 |
1.12e-57 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 194.48 E-value: 1.12e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 22 LMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAH 101
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 102 NETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHGWQWLFAVE 181
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HFSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 182 GLMATAVGIWAYWYLDNRPADAKWLSVAERRQIQDLLDREDQHKTSHG---RSLLTVLCQPSVLYLCLVYMLIQASVYGV 258
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTpkkYQIKELLKDRRVWGLALGQFLVNIGLGFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 259 VFYLPTQVGGLLGTRVgLMVGLVSAIPWVCALFAAWWIPGYSDRTGERRKTASLTLLMAAAGIA----CSVTFANPLLGM 334
Cdd:TIGR00893 235 LTWFPTYLVQERGLSI-LEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLvlslLMFATNYVNIPY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 335 LALCFAASGFIAVQ--PVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVAAL 412
Cdd:TIGR00893 314 AALALVALGFFGLGagAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGAL 393
|
...
gi 1204946024 413 LVL 415
Cdd:TIGR00893 394 SYL 396
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-423 |
3.36e-48 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 168.51 E-value: 3.36e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 6 ASLLAKISWRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCR 85
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 86 IMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEl 165
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 166 dgfsgLHGWQWLFAVEGLMATAVGIWAYWyldnrpadakwlsvaerrqiqdlldredqhktshgrslltvlcqpsvlYLC 245
Cdd:COG2271 160 -----AFGWRAAFLILGLPGLLLALLRFW------------------------------------------------LLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 246 LVYMLIQASVYGVVFYLPTQVGGLLGTRVGLMvGLVSAIPWVCALFAAWWIPGYSDRTGERRK-TASLTLLMAAAGIACS 324
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA-GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 325 VTFANPLLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHsPAAGLYLLS 404
Cdd:COG2271 266 ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLA 344
|
410
....*....|....*....
gi 1204946024 405 ATTVVAALLVLGIHSPGHK 423
Cdd:COG2271 345 ALALLAALLALLLLRETRK 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-415 |
1.66e-37 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 140.40 E-value: 1.66e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 11 KISWRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSW 90
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 91 GLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsg 170
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 171 LHGWQWLFAVEGLMATAVGIWAYWYLDNRPADAKwlsvaerrqiqdlldredQHKTSHGRSLLTVLCQPSVLYLCLVYML 250
Cdd:COG2223 155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA------------------AAAKASLRDQLEALRDPRFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 251 IQASVYGVVFYLPTQVGGLLGTRVGLMVGLVSAIPWVCALFAAWWiPGYSDRTGERRKTASLTLLMAAAGIACSVTFANP 330
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLG-GWLSDRIGGRRVLLIVFALMALGLLLLALALGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 331 LLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVA 410
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVA 375
|
....*
gi 1204946024 411 ALLVL 415
Cdd:COG2223 376 LVLTL 380
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-415 |
3.11e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.28 E-value: 3.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 20 LLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 100 AHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDGFsglhGWQWLFA 179
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 180 VEGLMATAVGIWAYWYLDNRPADAKwlsvaerrqiqdlLDREDQHKTSHGRSLLTVLCQPSVLYLCLVYMLIQASVYGVV 259
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESAR-------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 260 FYLPT---QVGGLLGTRVGLMVGLVSAIPWVCALFAAWWipgySDRTGERRKTASLTLLMAAAGIACSVTFANPLLGMLA 336
Cdd:cd06174 224 TLLPLfllDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL----SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1204946024 337 LCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVAALLVL 415
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-354 |
1.28e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.12 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 14 WRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLV 93
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 94 SAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHG 173
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------LFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 174 WQWLFAVEGLMATAVGIWAYWYLDNRPAdakwlsvaerrqiqdlldredQHKTSHGRSLLTVLCQPSVLYLCLVYMLIQA 253
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRP---------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 254 SVYGVVFYLPTQVGGLLGTRVGlMVGLVSAIPWVCALFAAWWIPGYSDRTGeRRKTASLTLLMAAAGIACSVTFANPLLG 333
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSAS-AAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLALAGSLWLL 299
|
330 340
....*....|....*....|.
gi 1204946024 334 MLALCFAASGFIAVQPVFWTF 354
Cdd:COG2814 300 LLALFLLGFGFGLLFPLLQAL 320
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-383 |
2.33e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.41 E-value: 2.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 20 LLLMYIMAFLDRANVGFA-KQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMM 98
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 99 FAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHGWQWLF 178
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 179 AVEGLMATAVGIWAYWYLDNRPADAKWLSVAERRQIqdlldredqhktshgRSLLTVLCQPSVLYLCLVYMLIQASVYGV 258
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL---------------IVAWKALLRDPVLWLLLALLLFGFAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 259 VFYLPT--QVGGLLGTRVGLMVGLVSAIpwvcALFAAWWIPGYSDRTGERRKT--ASLTLLMAAAGIACSVTFANPLLGM 334
Cdd:pfam07690 220 LTYLPLyqEVLGLSALLAGLLLGLGGLL----GAIGRLLLGRLSDRLGRRRRLllALLLLILAALGLLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1204946024 335 LALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAP 383
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
43-415 |
4.14e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.32 E-value: 4.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 43 ADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFP 122
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 123 GVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHGWQWLFAVEGLMATAVGIWAYWYLDNRPad 202
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD------ALGYRAPFLVCAALALLALVLALLLLPEPR-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 203 akwlSVAERRQIQDLLDRedqhktshgRSLLTVLCQPSVLYLCLVYMLIQASVYGVVFYLP---TQVGGLLGTRVGLMVG 279
Cdd:cd17325 176 ----PPPNKRAVSAARLR---------SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPlyaAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 280 LVSAIpwvcALFAAWWIPGYSDRTGeRRKTASLTLLMAAAGIACSVTFANPLLGMLALCFAASGFIAVQPVFWTFPSSYL 359
Cdd:cd17325 243 AQGLA----SALSQPPAGKLSDRIG-RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1204946024 360 AGSAAAASIALINSFGALGGFIAPVLKNWAETAFhSPAAGLYLLSATTVVAALLVL 415
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFL 372
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
24-383 |
7.82e-16 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 78.57 E-value: 7.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 24 YIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNE 103
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 104 TSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLlleldGFSGLHGWQWLFAVEGL 183
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLF-----GIAELYSWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 184 MATAVGIWAYWYLDNRPADAKwLSVAERRQIQDLldREDQHKTSHGRSLLTVLCQ-----PSVLYLCLVYMLIQASVYGV 258
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPQSCG-LPPAEEMPNEEP--DGDAEKKEEELTKKQIFLQyvllnKVLWYISLGYVFVYVVRTGI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 259 VFYLP---TQVGGLLGTRVGLMVGLVSAIPWVCALFAAWWIPGYSDRTGERRKTASLTLLMAAAGIACSVTFANPLlgML 335
Cdd:TIGR00881 236 LDWSPlylTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPL--MD 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1204946024 336 ALCFAASGFIAVQPV--FWTFPSSYLAGSAAAASIALINSFGALGGFIAP 383
Cdd:TIGR00881 314 LICLFALGFLVYGPQmlIGVIASELAPKKAAGTAAGFVGFFAYLGGILAG 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-354 |
3.73e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.43 E-value: 3.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 40 AFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAG 119
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 120 FFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLleldgfSGLHGWQWLFAVEGLMATAVGIWAYWYLDNR 199
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLGWRAAFLAIAVLALLAALLLWRLLPSL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 200 PADAKwlsvaerrqiqdlldredqHKTSHGRSLLTVLCQPSVLYLCLVYMLIQASVYGVVFYLP---TQVGGLLGTRVGL 276
Cdd:cd17324 178 PPKKP-------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLApflTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1204946024 277 MVGLVSaipwVCALFAAWWIPGYSDRTGeRRKTASLTLLMAAAGIACSVTFANPLLGMLALCFAASGFIAVQPVFWTF 354
Cdd:cd17324 239 LLLLFG----VAGVVGSPLAGRLADRGG-RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
42-415 |
1.12e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.80 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 42 QADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFF 121
Cdd:cd17475 23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 122 PGVILYLTYWFPSAVRGKAMGFFYFGAPLafifGSPLSGLLLELdgFSGLHGWQWLFAVEGLMATAVGIWAY-WYLDNRP 200
Cdd:cd17475 103 PGGGRAIMRWFPPRERGLAMGIRQTGVPL----GGALAAALLPP--LALHYGWRAAFVVAGLVSILAAVLFWlFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 201 ADAKWLSVAERRqiqdlldredqhktshgRSLLTVLCQPSVLYLCLVYMLIQASVYGVVFYLPTQVGGLLGTRVGLMVGL 280
Cdd:cd17475 177 ASAATESASTLL-----------------RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 281 VSAIPWVCALFAAWWiPGYSDRTGERRKTASLTLLMAAAGIACSVTFANP---LLGMLALCFAASGFIAV--QPVFWTFP 355
Cdd:cd17475 240 LAVAQLGGALGRIGL-GRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSpgtPLWLLVLLLILLGLFAIgwNGLYLTLV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 356 SSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVAALLVL 415
Cdd:cd17475 319 AESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
42-417 |
1.02e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.05 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 42 QADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFF 121
Cdd:COG2807 45 RADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGN 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 122 PGVILYLTYWFPSAVrGKAMGFFYFGAPLAFIFGSPLSGLLLELdgfsglHGWQWLFAVEGLMATAVGIWAYWYLDNRPA 201
Cdd:COG2807 125 VLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAA------LGWRGALAVWALLALLALLLWLPLLRRRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 202 DAkwlsvaerrqiqdlldredqHKTSHGRSLLTVLCQPSVLYLCLVYMLIQASVYGVVFYLPT--QVGGLLGTRVGLMVG 279
Cdd:COG2807 198 AA--------------------AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPilRDAGLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 280 LVSAIpwvcALFAAWWIPGYSDRTGERRKTASLTLLMAAAGIACsVTFANPLLGMLALCFAASGFIAVQPVFWTFPSSYL 359
Cdd:COG2807 258 LFQLA----GIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLG-LLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1204946024 360 AGSAAAASIA-LINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVAALLVLGI 417
Cdd:COG2807 333 RTPAEAAALSgMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-346 |
1.21e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.11 E-value: 1.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 17 LPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAA 96
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 97 MMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDGfsglhGWQW 176
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 177 LFAVEGLMATAVGIWAYWYLDNRPadakwlsvaerRQIQDLLDREDQHKTSHGRSLLTVLCQPSVLYLCLVYMLIQASVY 256
Cdd:cd17328 156 AFRVTGVLGVLLAILLLLFVREPP-----------RGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 257 GVVFYLPT------QVGGLLGTRVGLMVGLVSAIpwvCALFAAWWIPGYSDRTGERRKTA-----SLTLLMAAAGIACSV 325
Cdd:cd17328 225 ALAFWAPTfflrafGVGDLSSADVGLIFGAITCI---AGVLGVLLGGILADRLRRKTPRAdplvcAVGLLAAAPFLFLAL 301
|
330 340
....*....|....*....|.
gi 1204946024 326 TFANPLLGMLALCFAASGFIA 346
Cdd:cd17328 302 VLALSNLLLAWVLLFLGEFLL 322
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
14-415 |
6.91e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.44 E-value: 6.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 14 WRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLV 93
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 94 SAAMMFAHNETSFYLLRFLLGVAEAGFFPGVI-LYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLH 172
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE------AF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 173 GWQWLFAVEGLMATAVGIWAYWYLDNRPADAKwlsvaerrqiqdLLDREDQHKTSHGRSLLTVLCQPSVLYLCLVYMLIQ 252
Cdd:cd17355 156 GWRTALLVLALLALLVLVPVLLLLRRRPADLA------------LRAYDDASPASPGSTLKEALRSASFWLLALAFFLCG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 253 ASVYGVVFYLPTQVG--GLLGTRVGLMVGLVSAIPWVCALFAAWwipgYSDRTGERRKTASLTLLMAAAGIACSVTFANP 330
Cdd:cd17355 224 FAVVGLIVHLVPYLAdrGISPAAAAVALALIGLFNIVGRLLSGW----LGDRYSPRRLLAASYALRALGLALLLLLPFPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 331 LLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVA 410
Cdd:cd17355 300 LALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIA 379
|
....*
gi 1204946024 411 ALLVL 415
Cdd:cd17355 380 ALLVL 384
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-293 |
7.81e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.52 E-value: 7.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 3 TLPASLLAKISWRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLW 82
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 83 MCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLL 162
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 163 LEldgfsgLHGWQWLFAVEGLMATAVGIWAYWYLDNRPADAKWLSVAERRQIQDLLDREDQHKTSHGRSLLTVLCQPSVL 242
Cdd:COG0477 162 VA------ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLA 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1204946024 243 YLCLVYMLIQASVYGVVFYLPTQVGGLLGTRVGLMVGLVSAIPWVCALFAA 293
Cdd:COG0477 236 GAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLL 286
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
87-415 |
1.15e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.46 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 87 MVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELd 166
Cdd:cd17316 73 LLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPL- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 167 gFSGLHGWQWLFAVEGLMAtavgiwaywyldnrpadakwlsvaerrqiqdlldredqhktshgrsLLTVLCQPSVLYLCL 246
Cdd:cd17316 152 -LSGDWGWRILFLIGALPA----------------------------------------------LLALLLRRRTLLLIL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 247 VYMLIQASVYGVVFYLPT---QVGGLLGTRVGLMVGLVSAIPWVCALFAAWWipgySDRTGERRKTASLTLLMAAAGIAC 323
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTylqTVLGLSPATSSLYLLLISLGALVGALIAGLL----SDRIGRKKTLVIGLILSGILALPL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 324 SVTFANPLLGMLALCFAASGFIA-VQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYL 402
Cdd:cd17316 261 FYLLSGSPTLLLLLLFILSFFVGgVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340
|
330
....*....|...
gi 1204946024 403 LSATTVVAALLVL 415
Cdd:cd17316 341 LALLAIVALIVAL 353
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
15-200 |
1.62e-08 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 56.26 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 15 RLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVS 94
Cdd:cd17488 3 HILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 95 AAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRgkamGFFYFGAPLAFIFGSPLSGLLLeldGFSGLH-G 173
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNER----GFWWSIWNTSHNIGGALIPILT---GFAALTyG 155
|
170 180
....*....|....*....|....*..
gi 1204946024 174 WQWLFAVEGLMATAVGIWAYWYLDNRP 200
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
44-414 |
2.39e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.68 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 44 DTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPG 123
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 124 VILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDGFsglhgwQWLFAVEGLMAtAVGIWAYWYLDNRPADA 203
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGF------AVLFIVAAVLA-LLALLLVFLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 204 KWLSVAERRQIQDLLDredqhktshgrslltvlcqPSVLYLCLVYMLIQASVYGVVFYLPTQVGGLLGTRVGLMVGLVSA 283
Cdd:cd17489 178 AEEAEAGTRAFRRLVE-------------------KKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 284 IPWVCALFAAWWIpgysDRTGeRRKTASLTLLMAAAGIACSVTFANPLLGMLALCFAASGFIAVQPVFWTFPSSYLAGSA 363
Cdd:cd17489 239 ALLLSRPFSGKLS----DRKG-PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1204946024 364 AAASIALINSFGALGGFIAPVLknWAETAFHSPAAGLYLLSATTVVAALLV 414
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLL--LGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-388 |
6.18e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.28 E-value: 6.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 14 WRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLV 93
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 94 SAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHG 173
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP------VFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 174 WQWLFAVEGLmATAVGIWAYWYLdnRPADAKWLSVAERRQIQDLLDR--------------EDQHKTSHGRSLLTVLCQP 239
Cdd:TIGR00895 170 WRSLFYVGGI-APLLLLLLLMRF--LPESIDFLVSKRPETVRRIVNAiapqmqaeaqsalpEQKSTQGTKRSVFKALFQG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 240 ----SVLYLCLVYMLIQASVYGVVFYLPT---QVGGLLGTRVGLMVGLVSAipwvcALFAAWWIPGYSDRTGeRRKTASL 312
Cdd:TIGR00895 247 ktarITVLLWLLYFMLLVGVYFLTNWLPKlmvELGFSLSLAATGGALFNFG-----GVIGSIIFGWLADRLG-PRVTALL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1204946024 313 TLLMAAAGIACSVTFANPLLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNW 388
Cdd:TIGR00895 321 LLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
57-193 |
1.30e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 53.33 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 57 GVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFA--HNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPS 134
Cdd:cd17380 41 SSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPV 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1204946024 135 AVRGKAMGF----FYFGAPLAFIFGSplsgLLLEldgfsgLHGWQWLFAVEGLMATavgIWAY 193
Cdd:cd17380 121 SERSRAVSIvtagSYLGTLLGGLIGP----LLLE------YYGWPSVFYFFGLLGL---LWAL 170
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-180 |
2.27e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.56 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 20 LLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMF 99
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 100 AHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHGWQWLFA 179
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE------LFGWRWIFL 154
|
.
gi 1204946024 180 V 180
Cdd:cd17321 155 I 155
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-415 |
5.77e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 5.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 73 IMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAF 152
Cdd:cd17473 58 LADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 153 IFGSPLSGLLLELdgfsglhGWQWLFAVEgLMATAVGIWAYWYLDNRPadakwlsvaerrqiqdlldREDQHKTSHGRSL 232
Cdd:cd17473 138 VVFLLLGGALAEI-------GWRAPFLVY-LLALPVLILVLLFLPEPA-------------------RKSKSAASPGAAT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 233 LTVLCQPSVLYLCLVYMLIQASVYGVVFYLPTQVGGLLGTRvGLMVGLVSAIPWVCALFAAWWIPGYSDRTGERRKTASL 312
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS-AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 313 TLLMAAAGIACSVTfANPLLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETA 392
Cdd:cd17473 270 FALMALGFLLLALA-SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|...
gi 1204946024 393 FHSPAAGLYLLSATTVVAALLVL 415
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLL 371
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
14-251 |
5.93e-07 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 51.25 E-value: 5.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 14 WRLlPFLLLMYI---MAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSW 90
Cdd:PRK11663 20 WRR-HILITMYLgyaLFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIAT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 91 GLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGkamgFFYFGAPLAFIFGSPLSGLLLeldGFSG 170
Cdd:PRK11663 99 GIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERG----GWWAIWNTAHNVGGALIPLVV---GAIA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 171 LH-GWQWLFAVEGLMATAVGIWAYWYLDNRPADAKWLSVAERRQIQDLLDREDQHKTSHGRSLLT--VLCQPSVLYLCLV 247
Cdd:PRK11663 172 LHyGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGAGLSRKEILTkyVLLNPYIWLLSFS 251
|
....
gi 1204946024 248 YMLI 251
Cdd:PRK11663 252 YVLV 255
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
24-351 |
1.51e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.93 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 24 YIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNE 103
Cdd:cd17345 12 YAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 104 TS----FYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFY----FGAPLAfifgSPLSGLLLeldGFSGLHGWQ 175
Cdd:cd17345 92 TSsvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNishnVGGGLV----GPLAGLGL---AIFGDGWWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 176 WLFAVEGLMATAVGIWAYWYLDNRPADAKWLSVAERR--QIQDLLDREDQHKTSHGRSLLT-VLCQPSVLYLCLVYMLIQ 252
Cdd:cd17345 165 GAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKgdYPEEADGEEEEQELSAWEIFVKyVLKNKLLWYIAIANVFVY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 253 ASVYGVVFYLPTQVGGLLGTRVGLMVGLVS-----AIPWVcaLFAAWwipgYSDRTGERRKTASLTLLMAAAGIACSVTF 327
Cdd:cd17345 245 LVRYGILDWAPTYLSEVKGFSKAQAMWAFSlfewaAIPGT--LLAGW----LSDKLFKGRRAPTGIIFMILVIVALIVYW 318
|
330 340
....*....|....*....|....
gi 1204946024 328 ANPLLGMLALCFAASGFIAVQPVF 351
Cdd:cd17345 319 LAPNVLVDLIALIALGFLIYGPVM 342
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
43-414 |
1.54e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.94 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 43 ADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNE-TSFYLLRFLLGVAEAGFF 121
Cdd:cd17341 27 DDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSyWGLLVLGFLLGFAGANFA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 122 PGvILYLTYWFPSAVRGKAMGFFY----FGAPLAFIFGSPLSGLLLELDGFSGlhgWQWLFAVEGLMATAVGIwAYWYLD 197
Cdd:cd17341 107 SG-QPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVFDGGFVG---WRNAFFVPGILLAIAAV-LVLLFG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 198 NRPADAKWLSVAERRQIqdlldredqhktshgrslLTVLCQPSVLYLCLVYMLIQASVYGVVFYLPTqvggLLGTRVGLM 277
Cdd:cd17341 182 DDLPTGKASALEFLKVQ------------------LAVLKNYRTWILSLLYGVTFGSFVGFSNVLPT----YFKTRFGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 278 VGLVSAIPWVCALFAAWWIP--GY-SDRTGERRKTASLTLLMAAAGIACSVTFANPLLGM-----LALCFAASGFIAVQP 349
Cdd:cd17341 240 LVTAGILAALFPLAGALARPagGWlSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLvlflaLFVALGLGAGAGNGS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1204946024 350 VFWTFPSSYLAGSAAAASIALinSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVAALLV 414
Cdd:cd17341 320 VFRMVPFIFRRELGAVTGLVG--AIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
14-200 |
1.66e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.96 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 14 WRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLV 93
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 94 SAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLeldgfsGLHG 173
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA------SYYG 155
|
170 180
....*....|....*....|....*..
gi 1204946024 174 WQWLFAVEGLMATAVGIWAYWYLDNRP 200
Cdd:cd17312 156 WRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-190 |
2.93e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.49 E-value: 2.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 57 GVFFVGYALLEV----PSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWF 132
Cdd:TIGR00880 1 GLLLAGYALGQLiyspLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1204946024 133 PSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDgfsglhGWQWLFAVEGLMATAVGI 190
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFL------GWRAPFLFLAILALAAFI 132
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
46-196 |
2.21e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 46 GLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVI 125
Cdd:cd17325 231 GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1204946024 126 LYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELdgfsglHGWQWLFAVEGLMATAVGIWAYWYL 196
Cdd:cd17325 311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA------FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
57-196 |
2.48e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.07 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 57 GVFFVGYALLEVPSNLIMHRVGARlwmcrIMVSWGLVSAAM------MFAH-NETSFYLLRFLLGVAEAGFFPGVILYLT 129
Cdd:cd17318 63 SSFFYGYILTQIPGGYLAEKYGAK-----RVLGYSILITALltlltpLAARgGYGALIVLRILQGLAQGVTFPAMHALWA 137
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1204946024 130 YWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHGWQWLFAVEGLMATAVgIWAYWYL 196
Cdd:cd17318 138 KWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCE------SLGWPSIFYIFGGLGLLW-CLLWFFL 197
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
137-354 |
3.27e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 137 RGKAMGFFYFGAPLAFIFGSPLSGLLLELDGFSGLHGWQWLFAVEGLMATAVGIWAYWYLDNRPadakwlsvaerrqiqd 216
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERP---------------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 217 lldREDQHKTSHGRSLLTVLCQPSVLYLCLVYMLI---QASVYGVVFYLPTQVGGLLGTRVGLMVGLVSAIPWVCALFAA 293
Cdd:COG2211 209 ---VPEEEKVSLKESLKALLKNRPFLLLLLAYLLFflaLALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1204946024 294 WWipgySDRTGeRRKTASLTLLMAAAGIACSVTF--ANPLLGMLALCFAASGFIAVQPVFWTF 354
Cdd:COG2211 286 RL----AKRFG-KKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAM 343
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
4-174 |
3.63e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 3.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 4 LPASLLAKISWRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWM 83
Cdd:cd17316 167 LPALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 84 CRIMVSWGLVSAAMMFAHNETSFYLL--RFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGL 161
Cdd:cd17316 247 VIGLILSGILALPLFYLLSGSPTLLLllLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIAL 326
|
170
....*....|...
gi 1204946024 162 LLELDGFSGLHGW 174
Cdd:cd17316 327 LLASTGGTGVPAL 339
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
57-206 |
3.79e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 45.72 E-value: 3.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 57 GVFFVGYALLEVPSNLIMHRVGaRLWMCRIMVSWGLVSAAMMFAHNETSFYLL----RFLLGVAEAGFFPGVILYLTYWF 132
Cdd:cd17357 56 SIFFIGGAIGSFISAFLANRFG-RKNGLLISNALLVVSSLLMFLSKSAKSPELlifgRFLVGIACGLSTGFVPMYLQEIS 134
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1204946024 133 PSAVRGkAMGFFYfgaPLAFIFGSpLSGLLLELDG-FSGLHGWQWLFAVEGLMATAVGIWAYWYldnrPADAKWL 206
Cdd:cd17357 135 PSELRG-ALGSLT---QIGVTLGI-LLGQVFGLPSvLGTETLWPYLLFFPGIPALLQLAALPFF----PESPKFL 200
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
11-191 |
5.42e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 5.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 11 KISWRLLP--FLLLMYIMAFLDRANVGFAKQAFQA-DTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIM 87
Cdd:cd17370 192 KTSLKKLPkaFWLYLLAVALFALGNFSFAFLILRAqELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 88 VSWGLVSAAMMFAHNETSFYLLRFLLGV---AEAGFFPGVILYLTywfPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLE 164
Cdd:cd17370 272 LSLALAYLGFALGSSLWLLLLGFILWGLymgAQESIERAAVADLV---PAELRGTAYGLFNTVVGIGWLLASLIAGYLWD 348
|
170 180
....*....|....*....|....*..
gi 1204946024 165 ldgfsgLHGWQWLFAVEGLMATAVGIW 191
Cdd:cd17370 349 ------LISPSAAFLFSAVLALIALLL 369
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-420 |
6.56e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 6.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 20 LLLMYIMAF--LDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAM 97
Cdd:cd17365 2 ALCFLIIVLdgFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 98 MFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLHGWQWL 177
Cdd:cd17365 82 AFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIP------AFGWRSV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 178 FAVEGLMAtavgiwaywyldnrpadakwlsvaerrqiqdlldredqhktshgrsLLTVLCQPSVLYLCLVYMLIQASVYG 257
Cdd:cd17365 156 FLLGGVPP----------------------------------------------LILLPLLRGTLLLWVTFFMGLLLVYL 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 258 VVFYLPT--QVGGLLGTRVGLMVGLVSAIPWVCALFAAWwipgYSDRTGeRRKTASLTLLMAAAGIACSVTFANPLLGML 335
Cdd:cd17365 190 LNSWLPKlmVEAGYSLSQALTITLLLNIGGVIGSLLLGW----LADRFG-PKRVLALFFALGAVSLALLGVSPASLVLLY 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 336 ALCFAA-SGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVAALLV 414
Cdd:cd17365 265 VLVFLAgACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAV 344
|
....*.
gi 1204946024 415 LGIHSP 420
Cdd:cd17365 345 LLLRLR 350
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
109-347 |
7.35e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 44.73 E-value: 7.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 109 LRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDGfsglhGWQWLFAVEGLMATAV 188
Cdd:TIGR00894 137 CRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVGCAW 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 189 GIWAYWYLDNRPADAKWLSVAERRQIQDLLDREDqhktSHGRSLLTVLCQPSVLYLCLVYMLIQASVYGVVF---YLPT- 264
Cdd:TIGR00894 212 SLLWFVFPADDPSIHPCISKFEKKYINSSLQGQK----GSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTIlptYLPTf 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 265 --QVGGLLGTRVGLMVGLVSAIPWVCALFAawwipGYSDRTGERRKTASLTllmAAAGIACSVTFANPLLGMLALCFAAS 342
Cdd:TIGR00894 288 isWVLRVSGKENGLLSSLPYLFAWLCSIFA-----GYLADFLKSSKTLSLT---AARKIFNGIGGLGPGIFAYALPYLSA 359
|
....*
gi 1204946024 343 GFIAV 347
Cdd:TIGR00894 360 AFYLT 364
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
77-194 |
1.73e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.40 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 77 VGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWF-PSAVRGKAMGFFYFGAPLAFIFG 155
Cdd:cd17476 60 YGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALG 139
|
90 100 110
....*....|....*....|....*....|....*....
gi 1204946024 156 SPLSGLLLELDgfsglhGWQWLFAVEGLMATAVGIWAYW 194
Cdd:cd17476 140 GVFGGLFAQLA------WWPWIFWFLAILAAIVAVAAIF 172
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
36-347 |
5.03e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.90 E-value: 5.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 36 FAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFA-HNETSFYLLRFLLG 114
Cdd:TIGR00886 23 LAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 115 VAEAGFFPGvILYLTYWFPSAVRGKAMGFF----YFGAPLAFIFGSPLSGLLLELDGFSGLHGWQW-LFAVEGLMATAVG 189
Cdd:TIGR00886 103 IAGGSFASC-MPWISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWaFVIVPAGILLLPA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 190 IWAYWYLDNRPADAKwlsvAERRqiqdlLDREDQHKtshgrslltVLCQPSVLYLCLVYMLIQASVYGVVFYLPTqvggL 269
Cdd:TIGR00886 182 LLIFFVGADTPPGKP----ATGK-----LSFKEALK---------VFGNRHTWILALLYSVTFGSFLGVSSIFAM----L 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 270 LGTRVGLMVGLVSAIPWVCALFAAWWIPG---YSDRTGERRKTAsLTLLMAAAGIACsVTFANPLLGMLALCFAASGFIA 346
Cdd:TIGR00886 240 FKDQFGLSKVQAGAYASLGGFLGSLARPAggaISDRLGGARKLL-MNFLGVAMGAFL-VVLGLVSDGSLAAFIVLFVALF 317
|
.
gi 1204946024 347 V 347
Cdd:TIGR00886 318 F 318
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
56-417 |
5.43e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 5.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 56 AGVFFVGYALLEVPSNL----IMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYW 131
Cdd:cd17329 37 VGLVLALSAVAGIVASLiggrLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 132 FPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELDGfsglhgwQWLFAVEGLMATAVGIWAYWYLDNRPADakwlsvaer 211
Cdd:cd17329 117 TTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-------RLLFLAAAVLFLLAALVLLFLLPETRPK--------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 212 rqiqdlldREDQHKTSHGRSLLTVLCQPSVLYLCLVYMLIQASVYGVVFYLPTQVGGLLGTRVGlMVGLVSAIPWVCALF 291
Cdd:cd17329 181 --------RRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES-LLGLLLALNALLIVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 292 AAWWIPGYSDRTGeRRKTASLTLLMAAAGIACSVTFANPLLGMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALI 371
Cdd:cd17329 252 LQFPVARLVERFR-LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1204946024 372 NSFGALGGFIAPVLKNWAeTAFHSPAAGLYLLSATTVVAALLVLGI 417
Cdd:cd17329 331 ALAWGLGRAIGPLVGGLL-LDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-194 |
6.45e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 6.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 16 LLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYalleVPSNLIMHRVGARLWMCRIMVSWGLVSA 95
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA----PLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 96 AMMFA--HNETSFYLLRFLLGVAEAGFF-------PGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELD 166
Cdd:COG2211 310 LLFFLgpGNLWLLLVLAALAGIGLGAILvlpwamlADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
170 180 190
....*....|....*....|....*....|....*.
gi 1204946024 167 GF--------SGLHGWQWLFAVEGLMATAVGIWAYW 194
Cdd:COG2211 390 GYvagaaqspSALTGIRLLFFLLPAVLLLLAALLLL 425
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
44-352 |
1.04e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 41.10 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 44 DTGLSDAAFAFGA--GVFFVGYallevpsnlIMHRVGARlwMCRIMVSWGLVSAA--MMFAHNETSFYLL---RFLLGVA 116
Cdd:pfam00083 47 LSGLIVSIFSVGCfiGSLFAGK---------LGDRFGRK--KSLLIANVLFVIGAvlQGAAKGKWSVYQLivgRVLVGIG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 117 EAGFFPGVILYLTYWFPSAVRGkAMGFFY-----FGAPLAFIFGsplsgllLELDGFSGLHGWQWLFAVEGLMATAVGIW 191
Cdd:pfam00083 116 VGGASVLAPMYISEIAPKKLRG-ALGSLYqlaitFGILLAYIFG-------LGLNKTSNSDGWRIPLGLQLVPALLLIIG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 192 A-------YWYLDNRPADAKWLSVAERR----------QIQDLLDREDQHKTSHGRSLLTVLCQPSVLYLCLVYMLIQAS 254
Cdd:pfam00083 188 LlflpespRWLVEKGRLEEAREVLAKLRgvpdvdreldEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 255 V-YGVVFYLPTQVGGLLGTRVGLMVGLVSAIPWVCALFAAWWIpgySDRTGeRRKT--ASLTLLMAAAGIACSVTF---- 327
Cdd:pfam00083 268 TgINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFL---VDRFG-RRPLllLGAAGMAICFVILGIVALlgvs 343
|
330 340
....*....|....*....|....*....
gi 1204946024 328 ----ANPLLGMLALCFAASGFIAVQPVFW 352
Cdd:pfam00083 344 ksdwAGIVAIVFIALFIAFFAMGWGPVPW 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-424 |
1.76e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 14 WRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLV 93
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 94 SAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAvRGKAMGFFYFGAPLAFIFGSPLSGLLLeldGFSGLHG 173
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLI---LLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 174 WQWLFAVEGLMATAVGIWAYwyldnrpadakwlsvaerRQIQDLLDREDQHKTSHGRSLLTVLCQPSVLYLCL---VYML 250
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFL------------------RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLaifLYVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 251 IQASVYGVVFYLPTQVGGLLGTRVGLMVGLVSAIPWVCALFAAWWIPGYSdrtgeRRKTASLTLLMAAAGIACSVTFANP 330
Cdd:COG0738 225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG-----PVRLLRLSALLAAVGLLLALLAPGP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 331 LLGMLALCFAASGFIAVQPVFWTFpSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFhSPAAGLYLLSATTVVA 410
Cdd:COG0738 300 WLALIGLALVGLGLSLMFPTIFSL-ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLI 377
|
410
....*....|....
gi 1204946024 411 ALLVLGIHSPGHKA 424
Cdd:COG0738 378 LLLALALKRKRRKK 391
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
13-194 |
2.48e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 13 SWRLLPFLLLMYIMAFLDRANVGFAKQAFQADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGL 92
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 93 VSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLEldgfsgLH 172
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD------AL 360
|
170 180
....*....|....*....|..
gi 1204946024 173 GWQWLFAVEGLMATAVGIWAYW 194
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
73-319 |
2.70e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.87 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 73 IMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAF 152
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 153 IFGSPLSGLLleLDGFSglhgWQWLFavegLMATAVGIWAYWYLdnrpadakwlsvaerrqiqDLLDredqhktshgrsl 232
Cdd:cd17503 134 AIGPTLGGWL--TDNLS----WRWIF----YINLPIGILALLLA-------------------PLLD------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 233 LTVLCQPSVLYLCLVYMLIQASVYGVVFYLPTQVGGLLG---TRVGLMVGLVSAIPWVCALFAAWwipgYSDRTGERRKT 309
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGysaFESGLVLAPGGLASAILSPLVGR----LLDKFGPRLLL 247
|
250
....*....|
gi 1204946024 310 ASLTLLMAAA 319
Cdd:cd17503 248 LAGLLLLALG 257
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
58-415 |
2.78e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 58 VFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVR 137
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGER 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 138 GKAMGFfYFGAPLAFIFGSPLSGllleldGFSGLHGWQWLFAVEGLMATAVGIWAYWYLDNRPADAKWLSVAERRqiqdl 217
Cdd:cd17474 122 AKAMGL-YEAALGLGIAVGPLLG------GLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLR----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 218 ldreDQHKTSHGRSLLTVLCQPSVLYLCLvymliqasvYGVVFYLPT---QVGGLLGTRVGLMVGLVSAIPWVCALFAAW 294
Cdd:cd17474 190 ----DLKKALRGRGLLTFLVSAFLYFFLY---------FAFLTYLPFlleLLYGISPIIIGLLFAGWSVLLALGSLFVGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 295 WIPgysDRTGERRKTASLTLLMAAAGIacsVTFANPLLGMLALCFAASGFI--AVQPVFWTFPSSYLAGSAAAASIALIN 372
Cdd:cd17474 257 LLK---KRFGARRILVIGLLLYALSLL---LLGFVPSLALLLIAIVLFGLGlgLNLPLLTTLVTELAPEEERGTASSLYN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1204946024 373 SFGALGGFIAPVLKNWAetAFHSPAAGLYLLSATTVVAALLVL 415
Cdd:cd17474 331 FVRFLGQAVGPLLFGLL--LEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-415 |
2.84e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 43 ADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFP 122
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 123 GVILYLTYWFPSAVRGKAMGFFYfgapLAFIFGSPLSGLLLeldGFSGLHGWQWLFAVEGLMATAVgIWAYWYLDNRPAd 202
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYS----TVLGLGFALGPLLL---ALVGTAGALPFLIAAVLLLLAL-VPLLLTRRAAPE- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 203 akwlsvaerrqiqdlldredQHKTSHGRSLLTVLCQPSVLYLCLVYMLIQASVYGVVFYLPTQVGgLLGTRVGLMVGLVS 282
Cdd:cd17477 175 --------------------IEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 283 AIPWVCALFAAWWipgySDRTGERRKTASLTLLMAAAGIACSVTFANPLLgMLALCFAASGFI-AVQPVFWTFPSSYLAG 361
Cdd:cd17477 234 LGGLLLQWPLGWL----ADRFDRRRVLLGCALLGALAALLLPLVPGLPLA-LLVLLFLWGGAAgPLYTLALALAGDRLPG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1204946024 362 SAAAASIALINSFGALGGFIAPVLKNWAetAFHSPAAGLYLLSATTVVAALLVL 415
Cdd:cd17477 309 DELVAANAALLLLYGLGSVIGPLLAGAL--MDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
42-415 |
5.05e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 42 QADTGLSDAAFAFGAGVFFVGYALLEVPSNLIMHRVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFF 121
Cdd:cd06180 26 LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 122 PGVILYLTYWFPSAVRGKAMGFFYFGAPLafifGSPLSGLLLELDGFSGLH---GWQWLFAVEGLMATAVGIWAYwyldN 198
Cdd:cd06180 106 VFGSNLVLHHATAAGRGHLIGLLFAGVGL----GIALSGLLVPAGLGGGLSwraGWLALALLSAVLLLLSFLLLR----R 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 199 RPADAKWLSVAERRQIQDLldredqhktshgrslltvlcqpSVLYLCLVYMLIQASVYGVVFYLPTQVGGLLGTRvgLMV 278
Cdd:cd06180 178 GPSAPTEASAAESAPGLNR----------------------PLWRLALAYGLFGFGYIITATFLPLIARETGAGS--LLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 279 GLVSAIPWVCALFAAWWIPGYSDRTGERRKTAsLTLLMAAAGIACSVTFANPLLGMLALCFAASGFIAVQPVFWTFPSSY 358
Cdd:cd06180 234 GLLWSLFGLAAVPSCFLWGALSDRWGTRRALA-ANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALAREL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1204946024 359 LAGSAAAASIALINSFGaLGGFIAPVLKNWAETAFHSPAAGLYLLSATTVVAALLVL 415
Cdd:cd06180 313 APPAAPRALALMTASFG-VGQILGPLLAGWLADATGGFAPALILAAAALVVAALLAL 368
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
76-191 |
5.36e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 38.91 E-value: 5.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 76 RVGARLWMCRIMVSWGLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYWFPSAVRGKAMGFFYFGAPLAFIFG 155
Cdd:PRK03893 81 RYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVA 160
|
90 100 110
....*....|....*....|....*....|....*.
gi 1204946024 156 SPLSGLLLEldgfsgLHGWQWLFAVeGLMATAVGIW 191
Cdd:PRK03893 161 AQVYSLVVP------VWGWRALFFI-GILPIIFALW 189
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
91-415 |
5.95e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 5.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 91 GLVSAAMMFAHNETSFYLLRFLLGVAEAGFFPGVILYLTYwFPSAVRGKAMGFFYFGAPLAFIFGSPLSGLLLELdgfsg 170
Cdd:cd17490 73 VLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASY-FPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEH----- 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 171 lHGWQWLFavegLMATAVGIWAYWYLdnrpadakwLSVAERRqiqdlldREDQHKTSHGRSLLTVLCQPSVLYLCLVYML 250
Cdd:cd17490 147 -FGMRAPF----LLAALAGVLGFILS---------LFIKEER-------REKKPVLTELKELLSVLKDKKLLFFSLLAIL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 251 IQASVYGVVFYLPTQVGGLLG---TRVGLMVGLVSAIPWVCALFAAWWIpgySDRTGERRKTASLTLLMAAAGIACSVTF 327
Cdd:cd17490 206 QQMITFSTTFGFTPLIAKQLGassFQLGLLSIIYLLPNALASLLSGTLF---YKKLGERNTIIIGFLLLGAYCFLIPFAP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 328 ANPLLgMLALCFAASGFIAVQPVFWTFPSSYLAGSAAAASIALINSFGALGGFIAPVLKNWAETAFhSPAAGLYLLSATT 407
Cdd:cd17490 283 NLTLL-YLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAF-GLQTGFFVIGVIA 360
|
....*...
gi 1204946024 408 VVAALLVL 415
Cdd:cd17490 361 LLAAILSL 368
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
150-347 |
8.06e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 8.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 150 LAFIFGSPLSGLLLELDGFsglhgwQWLFAVEGLMATAVGIWAYWYLDNRPAdakwlsvaerrqiqdlldreDQHKTSHG 229
Cdd:cd17471 136 LAWVIGPPLAFLLLDVLGF------TGLFLLAALLYLVVALLVLFLLPSVKP--------------------PAQKATPA 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946024 230 RSLLTVLCQPSVLYLCLVYMLIQA--SVYGVvfYLP---TQVGGLLGTRVGLMVGLVSAIPWVCALFAAWWipgySDRTG 304
Cdd:cd17471 190 SSLVKAPVNRRLLLLFAAFTLLFAanSMYII--AMPlyvTNELGGSESWVGLLFGLAAALEIPIMLLAGLL----AKRFG 263
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1204946024 305 ERRktasltlLMAAAGIAC-----SVTFANPLLGMLALCFAASGFIAV 347
Cdd:cd17471 264 KRR-------LLLAGFLAGvlfylGLALATSLWQLIALQLLNAIFIGI 304
|
|
| |
