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Conserved domains on  [gi|1204946438|ref|WP_087694263|]
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MULTISPECIES: OmpA family protein [unclassified Pseudomonas]

Protein Classification

OmpA family protein( domain architecture ID 10163224)

OmpA family membrane protein acts as a porin with low permeability that allows slow penetration of small solutes; may function in peptidoglycan binding

CATH:  3.30.1330.60
Gene Ontology:  GO:0016020|GO:0009279|GO:0015288|GO:0042834
PubMed:  17559395

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 215-298 1.12e-19

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


:

Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 83.37  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVEGDPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRM 294
Cdd:cd07185    23 KLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGVDASRITAVGYGESRPIASNDTEEGRAKNRRV 102


                  ....
gi 1204946438 295 EIMF 298
Cdd:cd07185   103 EIVI 106
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 215-298 1.12e-19

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 83.37  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVEGDPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRM 294
Cdd:cd07185    23 KLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGVDASRITAVGYGESRPIASNDTEEGRAKNRRV 102


                  ....
gi 1204946438 295 EIMF 298
Cdd:cd07185   103 EIVI 106
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 215-301 4.49e-16

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 77.90  E-value: 4.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVEGDPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRM 294
Cdd:COG2885   208 ELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSKGIPASRITAVGYGESRPVASNDTEEGRAKNRRV 287


                  ....*..
gi 1204946438 295 EIMFTQR 301
Cdd:COG2885   288 EIVVLKK 294
PRK10510 PRK10510
OmpA family lipoprotein;
161-299 1.53e-15

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 74.91  E-value: 1.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 161 WLDDYEPRLRLAIKDSNLQLERRDNVLVVIAPVDGSYNPKRpAMLLPVTLGPFTRVAKAVEGDPKTAVLVLGHVDTSGAE 240
Cdd:PRK10510   80 YMDVQEAKLRDKMRGTGVSVTRSGDNIILNMPNNVTFDSSS-ATLKPAGANTLTGVAMVLKEYPKTAVNVVGYTDSTGSH 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1204946438 241 PVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRMEIMFT 299
Cdd:PRK10510  159 DLNMRLSQQRADSVASALITQGVDASRIRTQGMGPANPIASNSTAEGKAQNRRVEITLS 217
type_VI_ompA TIGR03350
type VI secretion system peptidoglycan-associated domain; The flagellar motor protein MotB, ...
 215-297 5.02e-14

type VI secretion system peptidoglycan-associated domain; The flagellar motor protein MotB, the Gram-negative bacterial outer membrane protein OmpA (with an N-terminal outer membrane beta barrel domain) share a C-terminal peptidoglycan-associating homology region. This model describes a domain found fused to type VI secretion system homologs of the type IV system protein DotU (see model TIGR03349), with OmpA/MotB homology. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274533 [Multi-domain]  Cd Length: 137  Bit Score: 68.48  E-value: 5.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVEGDPkTAVLVLGHVDT----SGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRAL 290
Cdd:TIGR03350  51 RIAKALAAVP-GRITVVGHTDNvpirTARFPSNWHLSEARAKAVADVLAQAGGPAGRVRAEGRGDSEPIASNATAAGRAR 129


                  ....*..
gi 1204946438 291 NRRMEIM 297
Cdd:TIGR03350 130 NRRVEID 136
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 215-291 4.40e-10

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 56.21  E-value: 4.40e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1204946438 215 RVAKAVEG-DPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALN 291
Cdd:pfam00691  18 EIADLLKFpELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNFGVPPSRISVVGYGATKPITDNKTPEGRARN 95
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 215-298 1.12e-19

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 83.37  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVEGDPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRM 294
Cdd:cd07185    23 KLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGVDASRITAVGYGESRPIASNDTEEGRAKNRRV 102


                  ....
gi 1204946438 295 EIMF 298
Cdd:cd07185   103 EIVI 106
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 215-301 4.49e-16

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 77.90  E-value: 4.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVEGDPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRM 294
Cdd:COG2885   208 ELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSKGIPASRITAVGYGESRPVASNDTEEGRAKNRRV 287


                  ....*..
gi 1204946438 295 EIMFTQR 301
Cdd:COG2885   288 EIVVLKK 294
PRK10510 PRK10510
OmpA family lipoprotein;
161-299 1.53e-15

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 74.91  E-value: 1.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 161 WLDDYEPRLRLAIKDSNLQLERRDNVLVVIAPVDGSYNPKRpAMLLPVTLGPFTRVAKAVEGDPKTAVLVLGHVDTSGAE 240
Cdd:PRK10510   80 YMDVQEAKLRDKMRGTGVSVTRSGDNIILNMPNNVTFDSSS-ATLKPAGANTLTGVAMVLKEYPKTAVNVVGYTDSTGSH 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1204946438 241 PVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRMEIMFT 299
Cdd:PRK10510  159 DLNMRLSQQRADSVASALITQGVDASRIRTQGMGPANPIASNSTAEGKAQNRRVEITLS 217
type_VI_ompA TIGR03350
type VI secretion system peptidoglycan-associated domain; The flagellar motor protein MotB, ...
 215-297 5.02e-14

type VI secretion system peptidoglycan-associated domain; The flagellar motor protein MotB, the Gram-negative bacterial outer membrane protein OmpA (with an N-terminal outer membrane beta barrel domain) share a C-terminal peptidoglycan-associating homology region. This model describes a domain found fused to type VI secretion system homologs of the type IV system protein DotU (see model TIGR03349), with OmpA/MotB homology. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274533 [Multi-domain]  Cd Length: 137  Bit Score: 68.48  E-value: 5.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVEGDPkTAVLVLGHVDT----SGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRAL 290
Cdd:TIGR03350  51 RIAKALAAVP-GRITVVGHTDNvpirTARFPSNWHLSEARAKAVADVLAQAGGPAGRVRAEGRGDSEPIASNATAAGRAR 129


                  ....*..
gi 1204946438 291 NRRMEIM 297
Cdd:TIGR03350 130 NRRVEID 136
PRK08126 PRK08126
hypothetical protein; Provisional
 227-300 3.32e-11

hypothetical protein; Provisional


Pssm-ID: 236157 [Multi-domain]  Cd Length: 432  Bit Score: 64.33  E-value: 3.32e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1204946438 227 AVLVLGHVDT----SGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRMEIMFTQ 300
Cdd:PRK08126  355 KVTVTGHTDNqpirSAQFASNLVLSEKRAAQVAQMLQSAGVPASRLEAVGKGDAQPVADNRTPQGRAQNRRVEITVAE 432
MotB COG1360
Flagellar motor protein MotB [Cell motility];
168-303 4.15e-11

Flagellar motor protein MotB [Cell motility];


Pssm-ID: 440971 [Multi-domain]  Cd Length: 174  Bit Score: 61.01  E-value: 4.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 168 RLRLAIKDSNLQLERRDNVLVVIAPVDGSYNPKRpAMLLPVTLGPFTRVAKAVEGDPKtAVLVLGHVDtsgAEPVSQA-- 245
Cdd:COG1360    34 ALEENLLSGQVEVRITEEGLVIEIQDRVLFDSGS-AELTPEGRELLDKIAAVLAEVPN-RIRVEGHTD---NVPISTArf 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1204946438 246 -----LTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRMEIMFTQRTT 303
Cdd:COG1360   109 psnweLSAARAAAVVRYLIEGGVPPERLSAVGYGDTRPLAPNDTPEGRARNRRVEIVILRRAA 171
motB PRK08944
flagellar motor protein MotB; Reviewed
 216-300 3.13e-10

flagellar motor protein MotB; Reviewed


Pssm-ID: 236356 [Multi-domain]  Cd Length: 302  Bit Score: 60.79  E-value: 3.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 216 VAKAVEGDpktaVLVLGHVDTSgaePVSQA-------LTKERAQSIASI-FSLSGLKQDRLMLRGMGDLMPRAANDSNQG 287
Cdd:PRK08944  204 LLKDVPGI----ITVSGHTDNV---PISSElyrsnwdLSSARAVAVAHElLKVKGFDPQRLKVVGMADTQPLVPNDTAEN 276

                          90
                  ....*....|...
gi 1204946438 288 RALNRRMEIMFTQ 300
Cdd:PRK08944  277 RARNRRVEIIIEQ 289
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 215-291 4.40e-10

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 56.21  E-value: 4.40e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1204946438 215 RVAKAVEG-DPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALN 291
Cdd:pfam00691  18 EIADLLKFpELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNFGVPPSRISVVGYGATKPITDNKTPEGRARN 95
PRK09967 PRK09967
OmpA family protein;
200-299 3.16e-08

OmpA family protein;


Pssm-ID: 182172 [Multi-domain]  Cd Length: 160  Bit Score: 52.67  E-value: 3.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 200 KRPAMLLPVTLGPFTRVAKAVEGDPKTAVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSG-LKQDRLMLRGMGDLMP 278
Cdd:PRK09967   58 KNDYKLLPESQQQIQTMAAKLASTGLTHARMDGHTDNYGEDSYNEGLSLKRANVVADAWAMGGqIPRSNLTTQGLGKKYP 137

                          90       100
                  ....*....|....*....|.
gi 1204946438 279 RAANDSNQGRALNRRMEIMFT 299
Cdd:PRK09967  138 IASNKTAQGRAENRRVAVVIT 158
PRK07033 PRK07033
DotU family type VI secretion system protein;
215-296 4.35e-08

DotU family type VI secretion system protein;


Pssm-ID: 180801 [Multi-domain]  Cd Length: 427  Bit Score: 54.67  E-value: 4.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 215 RVAKAVeGDPKTAVLVLGHVDT----SGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRAL 290
Cdd:PRK07033  335 RVADAL-NQVKGNVLVTGYSDNvpirTARFPSNWELSQARAQAVRALLAARLGQPERVTAEGRGDSDPVAPNDSAENRAR 413


                  ....*.
gi 1204946438 291 NRRMEI 296
Cdd:PRK07033  414 NRRVEI 419
PRK09038 PRK09038
flagellar motor protein MotD; Reviewed
 227-297 6.03e-06

flagellar motor protein MotD; Reviewed


Pssm-ID: 181618 [Multi-domain]  Cd Length: 281  Bit Score: 47.31  E-value: 6.03e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1204946438 227 AVLVLGHVDTSgaePVSQA-------LTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRMEIM 297
Cdd:PRK09038  165 PIHVEGFTDNV---PIATAqfpsnweLSAARAASVVRLLADDGVAPSRLAAVGYGEFQPVADNDTAEGRARNRRVVLV 239
PRK10808 PRK10808
outer membrane protein A; Reviewed
 223-296 6.40e-06

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 47.76  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946438 223 DPKT-AVLVLGHVDTSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAAN--DSNQGR-------ALNR 292
Cdd:PRK10808  254 DPKDgSVVVLGYTDRIGSDAYNQGLSEKRAQSVVDYLVSKGIPADKISARGMGKSNPVTGNtcDNVKPRaalidclAPDR 333


                  ....
gi 1204946438 293 RMEI 296
Cdd:PRK10808  334 RVEI 337
PRK09039 PRK09039
peptidoglycan -binding protein;
230-301 8.92e-05

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 44.19  E-value: 8.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1204946438 230 VLGHVD-----TSGAEPVSQALTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRMEIMFTQR 301
Cdd:PRK09039  267 VDGHTDnvplsGTGRFRDNWELSSARAISVVKFLIALGVPADRLAAAGFGEFQPLDPGDTPEARARNRRIELKLTER 343
motB PRK08457
flagellar motor protein MotB; Reviewed
 246-298 1.66e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 181435 [Multi-domain]  Cd Length: 257  Bit Score: 39.70  E-value: 1.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1204946438 246 LTKERAQSIASIFSLSGLKQDRLMLRGMGDLMPRAANDSNQGRALNRRMEIMF 298
Cdd:PRK08457  180 LAAARAYNVMKVLIQYGINPNRLSFSSYGSNNPIAPNDSLENRLKNNRVEIFF 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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