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Conserved domains on  [gi|1204946590|ref|WP_087694415|]
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MULTISPECIES: AraC family transcriptional regulator [unclassified Pseudomonas]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11454547)

helix-turn-helix (HTH) transcriptional regulator containing an AraC family DNA-binding HTH domain controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.1310
Gene Ontology:  GO:0003700|GO:0043565|GO:0006355
PubMed:  9409145|8831795|15808743|2644244
SCOP:  4000332

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
173-257 2.47e-15

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 69.50  E-value: 2.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  173 ELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELaaPPIRIDELAFAAGFNSTSAFYSSFRQHTGQ 252
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRD--TDLSVTEIALRVGFSSQSYFSRAFKKLFGV 78


                   ....*
gi 1204946590  253 SPKAY 257
Cdd:smart00342  79 TPSEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
8-265 1.48e-14

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 71.73  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590   8 DSQKTQATAKLVLRHHLCWRDRDLDGVMSYYHPDIQYHDFFQNRVVGAGELREYLQASMPRGADEAIEHTDRIRADGDTA 87
Cdd:COG2207     3 LLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  88 FIQYRITLRGGQGLVSFRTSEAITVRDGLIWRVNEYASLVHEQSASRRETTRPTVSRLGLSPQQLSYMANDLQQYFERQQ 167
Cdd:COG2207    83 LALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 168 PYLDPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPPIriDELAFAAGFNSTSAFYSSFR 247
Cdd:COG2207   163 LLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSI--SEIAYELGFSSQSHFSRAFK 240

                         250
                  ....*....|....*...
gi 1204946590 248 QHTGQSPKAYVKQISLRA 265
Cdd:COG2207   241 KRFGVTPSEYRKRLRARA 258
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
173-257 2.47e-15

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 69.50  E-value: 2.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  173 ELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELaaPPIRIDELAFAAGFNSTSAFYSSFRQHTGQ 252
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRD--TDLSVTEIALRVGFSSQSYFSRAFKKLFGV 78


                   ....*
gi 1204946590  253 SPKAY 257
Cdd:smart00342  79 TPSEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
8-265 1.48e-14

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 71.73  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590   8 DSQKTQATAKLVLRHHLCWRDRDLDGVMSYYHPDIQYHDFFQNRVVGAGELREYLQASMPRGADEAIEHTDRIRADGDTA 87
Cdd:COG2207     3 LLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  88 FIQYRITLRGGQGLVSFRTSEAITVRDGLIWRVNEYASLVHEQSASRRETTRPTVSRLGLSPQQLSYMANDLQQYFERQQ 167
Cdd:COG2207    83 LALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 168 PYLDPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPPIriDELAFAAGFNSTSAFYSSFR 247
Cdd:COG2207   163 LLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSI--SEIAYELGFSSQSHFSRAFK 240

                         250
                  ....*....|....*...
gi 1204946590 248 QHTGQSPKAYVKQISLRA 265
Cdd:COG2207   241 KRFGVTPSEYRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
179-260 1.80e-14

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 66.84  E-value: 1.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 179 VAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAaPPIRIDELAFAAGFNSTSAFYSSFRQHTGQSPKAYV 258
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLED-TGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79


                  ..
gi 1204946590 259 KQ 260
Cdd:pfam12833  80 RR 81
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 19-118 2.06e-12

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 61.92  E-value: 2.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  19 VLRHHLCWRDRDLDGVMSYYHPDIQYHDFFqNRVVGAGELREYLQASMPRGADEAIEHTDRIrADGDTAFIQYRIT---L 95
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPG-GPLRGRDAIRAFFAALFAAFPDLRFEIHDVI-ADGDRVAVRWTVTgtiP 78

                          90       100
                  ....*....|....*....|...
gi 1204946590  96 RGGQGlVSFRTSEAITVRDGLIW 118
Cdd:pfam12680  79 PTGRG-VRVRGVDVFRFRDGKIV 100
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 171-267 3.64e-10

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 59.68  E-value: 3.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 171 DPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPpirIDELAFAAGFNSTSAFYSSFRQHT 250
Cdd:COG2169    98 EDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLS---VTDAAYAAGFGSLSRFYEAFKKLL 174

                          90
                  ....*....|....*..
gi 1204946590 251 GQSPKAYVKQISLRARA 267
Cdd:COG2169   175 GMTPSAYRRGGAGAAIR 191
PRK10371 PRK10371
transcriptional regulator MelR;
150-259 1.13e-05

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 45.97  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 150 QQLSYMANdlqqyferqqpYLDPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAppIRIDE 229
Cdd:PRK10371  195 QMLGFIAE-----------NYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTD--KSILD 261

                          90       100       110
                  ....*....|....*....|....*....|
gi 1204946590 230 LAFAAGFNSTSAFYSSFRQHTGQSPKAYVK 259
Cdd:PRK10371  262 IALTAGFRSSSRFYSTFGKYVGMSPQQYRK 291
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 108-257 1.24e-03

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 39.66  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 108 EAITVRDGLIWRvneYASLVHEQSASRREttrPTVSRLglspqqLSYMANDLQQYferqqpyldpeLDLQRVAKECGYSR 187
Cdd:TIGR04094 259 DVLKLRDSAIIY---FTELLHEISINHHS---PLIRAV------IQYINLNLYDP-----------LKVEEIAKQFFMSE 315

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 188 NQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPPiriDELAFAAGFNSTSAFYSSFRQHTGQSPKAY 257
Cdd:TIGR04094 316 SKLRKLFKKEMGISIQEYISKRKIEEAKYLLRSQIPV---SEVSNELGFYDLSHFSRTFKKHTGVSPKQY 382
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
173-257 2.47e-15

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 69.50  E-value: 2.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  173 ELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELaaPPIRIDELAFAAGFNSTSAFYSSFRQHTGQ 252
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRD--TDLSVTEIALRVGFSSQSYFSRAFKKLFGV 78


                   ....*
gi 1204946590  253 SPKAY 257
Cdd:smart00342  79 TPSEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
8-265 1.48e-14

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 71.73  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590   8 DSQKTQATAKLVLRHHLCWRDRDLDGVMSYYHPDIQYHDFFQNRVVGAGELREYLQASMPRGADEAIEHTDRIRADGDTA 87
Cdd:COG2207     3 LLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  88 FIQYRITLRGGQGLVSFRTSEAITVRDGLIWRVNEYASLVHEQSASRRETTRPTVSRLGLSPQQLSYMANDLQQYFERQQ 167
Cdd:COG2207    83 LALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 168 PYLDPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPPIriDELAFAAGFNSTSAFYSSFR 247
Cdd:COG2207   163 LLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSI--SEIAYELGFSSQSHFSRAFK 240

                         250
                  ....*....|....*...
gi 1204946590 248 QHTGQSPKAYVKQISLRA 265
Cdd:COG2207   241 KRFGVTPSEYRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
179-260 1.80e-14

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 66.84  E-value: 1.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 179 VAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAaPPIRIDELAFAAGFNSTSAFYSSFRQHTGQSPKAYV 258
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLED-TGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79


                  ..
gi 1204946590 259 KQ 260
Cdd:pfam12833  80 RR 81
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
14-123 1.58e-13

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 65.72  E-value: 1.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  14 ATAKLVLRHHLCWRDRDLDGVMSYYHPDIQYHD---FFQNRVVGAGELREYLQASMPRGADEAIEhTDRIRADGDTAFIQ 90
Cdd:COG3631     1 TNRELVRRFYAAFNAGDVDALLALLAEDVVWEDpggPGAGTYRGKEAVRAFFARLAAAFEDLRFE-VRRVVADGDRVVVE 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1204946590  91 YRI--TLRGGQGLVSFRTSEAITVRDGLIWRVNEY 123
Cdd:COG3631    80 GTVrgTVLATGKPYENRYADVFTVRDGKIVRVREY 114
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 19-118 2.06e-12

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 61.92  E-value: 2.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  19 VLRHHLCWRDRDLDGVMSYYHPDIQYHDFFqNRVVGAGELREYLQASMPRGADEAIEHTDRIrADGDTAFIQYRIT---L 95
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPG-GPLRGRDAIRAFFAALFAAFPDLRFEIHDVI-ADGDRVAVRWTVTgtiP 78

                          90       100
                  ....*....|....*....|...
gi 1204946590  96 RGGQGlVSFRTSEAITVRDGLIW 118
Cdd:pfam12680  79 PTGRG-VRVRGVDVFRFRDGKIV 100
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
7-131 8.43e-11

Ketosteroid isomerase homolog YybH [General function prediction only];


Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 58.23  E-value: 8.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590   7 DDSQKTQATAKLVLRHHLCWRDRDLDGVMSYYHPDIQYHDFFQNRVVGAGELREYLQASMPRGADEAIEHTD-RIRADGD 85
Cdd:COG4319     3 RSAEDEAAIRALLAAFAEAFNAGDADALAALYAEDAVFFDPGGPPVRGREAIRAAWAAAFAAGPRVTFEVEDvRVLVSGD 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1204946590  86 TAFI--QYRITLRGGQGLVSFRTSEAITV---RDGLIWRvneyasLVHEQS 131
Cdd:COG4319    83 VAVVtgRWRLTGTDPDGEPVELAGRYTLVfrkQADGRWK------IVHDHA 127
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 171-267 3.64e-10

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 59.68  E-value: 3.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 171 DPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPpirIDELAFAAGFNSTSAFYSSFRQHT 250
Cdd:COG2169    98 EDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLS---VTDAAYAAGFGSLSRFYEAFKKLL 174

                          90
                  ....*....|....*..
gi 1204946590 251 GQSPKAYVKQISLRARA 267
Cdd:COG2169   175 GMTPSAYRRGGAGAAIR 191
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 134-267 1.14e-07

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 51.70  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 134 RRETTRPTVSRLglspqqLSYMANDLQQyferqqpyldpELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQH 213
Cdd:COG4977   204 PLGHRDPRLARA------QAWMEANLEE-----------PLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLER 266

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1204946590 214 LLAALELAAPPIriDELAFAAGFNSTSAFYSSFRQHTGQSPKAYVKQISLRARA 267
Cdd:COG4977   267 ARRLLETTDLSI--EEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARAAA 318
COG5485 COG5485
Predicted ester cyclase [General function prediction only];
18-117 8.42e-07

Predicted ester cyclase [General function prediction only];


Pssm-ID: 444236 [Multi-domain]  Cd Length: 130  Bit Score: 47.16  E-value: 8.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  18 LVLRH-HLCWRDRDLDGVMSYYHPDIQYHDFFQNRVVGAGELREY---LQASMPrgaDeaIEHT-DRIRADGDTAFIqyR 92
Cdd:COG5485     1 LVRRFfEEAWNEGDLDALDELVAPDFVYHGPLPGEPRGPEGFRAFlrgLRAAFP---D--LRFEiEDLIAEGDRVAV--R 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1204946590  93 ITLRG-----GQGL------VSFRTSEAITVRDGLI 117
Cdd:COG5485    74 WTFTGthtgeFLGIpptgkrVEFRGIDIYRFEDGKI 109
SnoaL COG4538
Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];
29-120 1.07e-05

Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];


Pssm-ID: 443604  Cd Length: 113  Bit Score: 43.73  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590  29 RDLDGVMSYYHPDIQYHDFFQNRVV-GAGELREYLQASMPRGADEAIEHTDRIrADGDTAFIQYRITLRGGQGlvsfrTS 107
Cdd:COG4538    19 RDIDAFLATYADDAEVYRFPGTLLAkGREAIRERYAERFANEPDLHAELVSRI-VLGNKVIDHELVTGLFGGG-----PV 92

                          90
                  ....*....|....*.
gi 1204946590 108 EAI---TVRDGLIWRV 120
Cdd:COG4538    93 EVVaiyEVEDGLIARV 108
PRK10371 PRK10371
transcriptional regulator MelR;
150-259 1.13e-05

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 45.97  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 150 QQLSYMANdlqqyferqqpYLDPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAppIRIDE 229
Cdd:PRK10371  195 QMLGFIAE-----------NYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTD--KSILD 261

                          90       100       110
                  ....*....|....*....|....*....|
gi 1204946590 230 LAFAAGFNSTSAFYSSFRQHTGQSPKAYVK 259
Cdd:PRK10371  262 IALTAGFRSSSRFYSTFGKYVGMSPQQYRK 291
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
170-261 1.80e-04

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 39.91  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 170 LDPELDLQRVAKECGYSRNQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPPIRidELAFAAGFNSTSAFYSSFRQH 249
Cdd:PRK10219   18 IDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIF--DIAMDLGYVSQQTFSRVFRRQ 95

                          90
                  ....*....|..
gi 1204946590 250 TGQSPKAYVKQI 261
Cdd:PRK10219   96 FDRTPSDYRHRL 107
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 224-259 4.41e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.13  E-value: 4.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1204946590 224 PIRIDELAFAAGFnSTSAFYSSFRQHTGQSPKAYVK 259
Cdd:pfam00165   8 NLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
224-267 9.97e-04

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 37.15  E-value: 9.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1204946590  224 PIRIDELAFAAGFnSTSAFYSSFRQHTGQSPKAYVKQISL-RARA 267
Cdd:smart00342   1 PLTLEDLAEALGV-SPRHLQRLFKKETGTTPKQYLRDRRLeRARR 44
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 108-257 1.24e-03

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 39.66  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 108 EAITVRDGLIWRvneYASLVHEQSASRREttrPTVSRLglspqqLSYMANDLQQYferqqpyldpeLDLQRVAKECGYSR 187
Cdd:TIGR04094 259 DVLKLRDSAIIY---FTELLHEISINHHS---PLIRAV------IQYINLNLYDP-----------LKVEEIAKQFFMSE 315

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 188 NQISYLLNQVLGQSFYRYVNQARLQHLLAALELAAPPiriDELAFAAGFNSTSAFYSSFRQHTGQSPKAY 257
Cdd:TIGR04094 316 SKLRKLFKKEMGISIQEYISKRKIEEAKYLLRSQIPV---SEVSNELGFYDLSHFSRTFKKHTGVSPKQY 382
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 166-260 3.99e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 38.09  E-value: 3.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1204946590 166 QQPYLDPELdlqrVAKECGYSRNQIsYLLNQVLGQSFYRYVNQARLQHLLAALELAAPPIRIDELAFAAGFNSTSAFYSS 245
Cdd:PRK09685  211 QEEILRPEW----IAGELGISVRSL-YRLFAEQGLVVAQYIRNRRLDRCADDLRPAADDEKITSIAYKWGFSDSSHFSTA 285

                          90
                  ....*....|....*
gi 1204946590 246 FRQHTGQSPKAYVKQ 260
Cdd:PRK09685  286 FKQRFGVSPGEYRRK 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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