|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
17-423 |
0e+00 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 628.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 17 IFKGSVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIM 96
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 97 ASGSFIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIIL 176
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 177 QNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFY 256
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 257 TYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAF 336
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 337 LLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVY 416
Cdd:cd17367 321 ALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVY 400
|
....*..
gi 1207689358 417 WRMGESS 423
Cdd:cd17367 401 LRMPETR 407
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
3-415 |
1.10e-162 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 465.82 E-value: 1.10e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 3 HTSEAANNRRITSNIFKGSVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADR 82
Cdd:PRK10406 10 SKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 83 YGRRAALTLSITIMASGSFIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTL 162
Cdd:PRK10406 90 HGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 163 VAGQLVALGVQIILQNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDESeqfSKMDSESRENAGTIKALMKHPKAVL 242
Cdd:PRK10406 170 IGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET---SQQETRALKEAGSLKGLWRNRRAFI 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 243 TVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPL 322
Cdd:PRK10406 247 MVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 323 FLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWLKSIGHESLFF 402
Cdd:PRK10406 327 LSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIGMETAFF 406
|
410
....*....|...
gi 1207689358 403 FYVAGCIAISFLV 415
Cdd:PRK10406 407 WYVTLMAVVAFLV 419
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
23-414 |
2.46e-141 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 409.74 E-value: 2.46e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 23 GNLIEWYDWYVYSAFAVY-FSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSF 101
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLvFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 102 IIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVLS 181
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 182 EADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKMDSESRENAGTIKALM-KHPKAVLTVIGLTLGGTVAFYTYTT 260
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLtKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 261 YLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMT 340
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207689358 341 VGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFL 414
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
20-417 |
2.74e-110 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 331.03 E-value: 2.74e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 20 GSVGNLIEWYDWYVY-SAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMAS 98
Cdd:cd17369 7 SLVGTAIEWYDFFIYgTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 99 GSFIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQN 178
Cdd:cd17369 87 ATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 179 VLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKM-DSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYT 257
Cdd:cd17369 167 LLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAkEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 258 YTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFL 337
Cdd:cd17369 247 FTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 338 LMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWL-KSIGHESLFFFYVAGCIAISFLVY 416
Cdd:cd17369 327 AVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALvAATGSWWPVALYLAALAVISLVAA 406
|
.
gi 1207689358 417 W 417
Cdd:cd17369 407 L 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
17-421 |
5.97e-92 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 284.27 E-value: 5.97e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 17 IFKGSVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIM 96
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 97 ASGSFIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIIL 176
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 177 QNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKMDSESRENaGTIKALMKHPKAVLTVIGLTLGGTVAFY 256
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRR-ELFALLANNRRIILLGMLLVAGSTVTFY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 257 TYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAF 336
Cdd:cd17368 240 FTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 337 LLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWL-KSIGHESLFFFYVAGCIAISFLV 415
Cdd:cd17368 320 LVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLiELTGSPLAPAWYLMGAALLGLLA 399
|
....*.
gi 1207689358 416 YWRMGE 421
Cdd:cd17368 400 TLMLRE 405
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
1-392 |
1.74e-84 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 265.65 E-value: 1.74e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 1 MAHTSEAANNRRITSNIFKGSVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYA 80
Cdd:PRK15075 1 MSTMTPAASRESKARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 81 DRYGRRAALTLSITIMASGSFIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQyv 160
Cdd:PRK15075 81 DRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQ-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 161 tlVAGQLVA------LGVqiILQNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKMdsESRENAGTI-KA 233
Cdd:PRK15075 159 --SASQQVAvvfaalLGY--LLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLAR--KHRPSMREIfRS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 234 LMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFmvnsvglDKGVVSWINFCALLVFVVIQ-------PIAGMLSDKIGRRP 306
Cdd:PRK15075 233 LAANWRIVLAGMLMVAMTTVSFYLITVYTPTF-------GKTVLHLSAADSLLVTLCVGvsnfiwlPIGGALSDRIGRRP 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 307 LLMSFGILGTLLTVPLFLFMkqAHNPVMAFLLMtVGLIIVTGYTSIN-AIVKA--ELFPTEIRALGVGLPYGLTVAIFGG 383
Cdd:PRK15075 306 VLIAFTVLAILTAYPALSWL--VAAPSFARMLA-VELWLSFLYGSYNgAMVVAltEVMPAEVRTAGFSLAYSLATAIFGG 382
|
....*....
gi 1207689358 384 TAEFIALWL 392
Cdd:PRK15075 383 FTPAISTWL 391
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
21-423 |
9.00e-82 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 256.90 E-value: 9.00e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 21 SVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGS 100
Cdd:cd17366 5 ALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAAST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 101 FIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVL 180
Cdd:cd17366 85 FCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 181 SEADMISWGWRIPFVIGAIGALSVLWLRRtmdeseqfskmdsesrenagtikalmkhpkAVLTVIGLTLGGTVAFYTYTT 260
Cdd:cd17366 165 TEAQMLDWGWRIPFLIAAPLGLVGLYLRR------------------------------PLLICIGLVLVFNVTNYMLLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 261 YLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMsFGILGTL-LTVPLFLFMKQAHNPVMAFLLM 339
Cdd:cd17366 215 YMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYA-AGLAGLLvLAVPAFLLMNSGSIAAIFIGLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 340 TVGLIIVTgYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWLKSI-GHESLFFFYVAGCIAISFLVYWR 418
Cdd:cd17366 294 VLGLLLSC-YTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSAtGNPLMPAYYLMVAAVVGLVAVLF 372
|
....*
gi 1207689358 419 MGESS 423
Cdd:cd17366 373 LTETA 377
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-415 |
8.46e-71 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 227.87 E-value: 8.46e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 17 IFKGSVGNLIEWYDWYVYSAFAVYFSSQFfpegDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIM 96
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 97 ASGSFIIACTPsygtigllSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIIL 176
Cdd:cd17316 77 GLATLLIGLLP--------TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 177 QNVLSeadmISWGWRIPFVIGAIGALSVLWLRRTMdeseqfskmdsesrenagtikalmkhpkavLTVIGLTLGGTVAFY 256
Cdd:cd17316 149 IPLLS----GDWGWRILFLIGALPALLALLLRRRT------------------------------LLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 257 TYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKqaHNPVMAF 336
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLS--GSPTLLL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207689358 337 LLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLV 415
Cdd:cd17316 273 LLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
9-392 |
2.40e-64 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 214.96 E-value: 2.40e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 9 NNRRITSNIFKGSVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAA 88
Cdd:PRK10642 10 DDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 89 LTLSITIMASGSFIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLV 168
Cdd:PRK10642 90 LAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 169 ALGVQIILQNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFS----KMDSESRENAGTIKA------LMKHP 238
Cdd:PRK10642 170 GAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQqhvdKLEQGDREGLQDGPKvsfkeiATKHW 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 239 KAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSVGL--DKGVVSWINFCALLVFVviQPIAGMLSDKIGRRPLLMSFGILGT 316
Cdd:PRK10642 250 RSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYseDHGVLIIIAIMIGMLFV--QPVMGLLSDRFGRRPFVILGSVALF 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207689358 317 LLTVPLFLfMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIAlWL 392
Cdd:PRK10642 328 VLAIPAFI-LINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAA-WL 401
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
22-419 |
2.19e-58 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 198.03 E-value: 2.19e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 22 VGNLIEWYDWYVYS-AFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGS 100
Cdd:PRK09952 29 AGAVVDWYDFLLYGiTAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIAT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 101 FIIACTPSYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVL 180
Cdd:PRK09952 109 ALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 181 SEADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKMDSE---SRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYT 257
Cdd:PRK09952 189 TDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEqaaAKKRIPVIEALLRHPGAFLKIIALRLCELLTMYI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 258 YTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMkQAHNPVM--- 334
Cdd:PRK09952 269 VTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMAL-EAQSIFWivf 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 335 -AFLLMTVGLIIVtgyTSINAIVKAELFPTEIRALGVGLPYGLTVAIFGGTAEFIALWLKSIGH---ESLFFFYVAGCIa 410
Cdd:PRK09952 348 fSIMLANIAHDMV---VCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYFGgswHSVAIYLLAGCL- 423
|
....*....
gi 1207689358 411 ISFLVYWRM 419
Cdd:PRK09952 424 ISAMTALLM 432
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-419 |
1.71e-40 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 148.88 E-value: 1.71e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 16 NIFKGSVGNLIEWYDWYVYSAFAVYFSSQFfpeGDSTSQLlntAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITI 95
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF---GLSAAQL---GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 96 MASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSfqyVTLVAGQLVALGVQII 175
Cdd:COG2223 80 LGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALG---LAAGGGNLGAAVAAFL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 176 LQNVLSeadmiSWGWRIPFVI-GAIGALSVLWLRRTMDESEQFSKmdSESRENAGTIKALMKHPKAVLTVIGLTLGGTvA 254
Cdd:COG2223 149 APLLIA-----AFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAA--AAAKASLRDQLEALRDPRFWLLSLLYFGTFG-S 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 255 FYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMkqaHNPVM 334
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL---GSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 335 AFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPyGLTVAIFGGTAEFIALWLKSI-GHESLFFFYVAGCIAISF 413
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLV-GAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVAL 376
|
....*.
gi 1207689358 414 LVYWRM 419
Cdd:COG2223 377 VLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-372 |
3.10e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 133.56 E-value: 3.10e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 21 SVGNLIEWYDWYVYSAFAVYFSSQFfpeGDSTSQLlntAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGS 100
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADL---GASPAQA---GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 101 FIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVl 180
Cdd:COG2814 90 LLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 181 seadmisWGWRIPFVIGA-IGALSVLWLRRTMDESEQFSKmdsesRENAGTIKALMKHPkAVLTVIGLTLGGTVAFYTYT 259
Cdd:COG2814 161 -------FGWRWVFLVNAvLALLALLLLLRLLPESRPAAR-----ARLRGSLRELLRRP-RLLLLLLLAFLLGFGFFALF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 260 TYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLmsfgILGTLLTVPLFLFMKQAHNPVMAFLLM 339
Cdd:COG2814 228 TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL----LIGLLLLALGLLLLALAGSLWLLLLAL 303
|
330 340 350
....*....|....*....|....*....|....
gi 1207689358 340 TV-GLIIVTGYTSINAIVkAELFPTEIRALGVGL 372
Cdd:COG2814 304 FLlGFGFGLLFPLLQALV-AELAPPEARGRASGL 336
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-420 |
1.19e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 124.21 E-value: 1.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 21 SVGNLIEWYDWYVYSAFAVYFSSQFfpeGDSTSQLlntAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGS 100
Cdd:COG2271 16 FLAYFLNYLDRSNLSVAAPPLQADL---GLSAAQL---GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 101 FIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFqyvTLVAGQLVALGVQIILQNVL 180
Cdd:COG2271 90 LLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI---FNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 181 SeadmiSWGWRIPFVIGAIGALSVLWLRrtmdeseqfskmdsesrenagtikalmkhpkaVLTVIGLTLGGTVAFYTYTT 260
Cdd:COG2271 159 A-----AFGWRAAFLILGLPGLLLALLR--------------------------------FWLLALAYFLVYFALYGFLT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 261 YLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMsfGILGTLLTVPLFLFMKQAHNPVMAFLLMT 340
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV--LAIGLLLAALALLLLALLPSPALAIALLF 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 341 VGLIIVTGYTSINAIVKAELFPTEIRALGVGLpYGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVYWRMG 420
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
21-422 |
2.96e-30 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 122.00 E-value: 2.96e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 21 SVGNLIEWYDWYVYSAFAVYFSSQFF--------PEGDSTSQLLNTAAIFAVGflmRPIGSLLMGRYADRYGRRAALTLS 92
Cdd:pfam00083 6 ALGGFLFGYDTGVIGAFLTLIDFFKNfglsksvsSLAALSVLSGLIVSIFSVG---CFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 93 ITIMASGSFIIACTPSYGTIGLLspiilVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGV 172
Cdd:pfam00083 83 NVLFVIGAVLQGAAKGKWSVYQL-----IVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 173 QIILQNVLSeadmiSWGWRIPFVIGAIGAL---------------------------SVLWLRRTMDESEQFSKM----- 220
Cdd:pfam00083 158 GLGLNKTSN-----SDGWRIPLGLQLVPALlliigllflpesprwlvekgrleeareVLAKLRGVPDVDRELDEIkdsle 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 221 --DSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVvsWINFCALLVFVVIQPIAGML 298
Cdd:pfam00083 233 agQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSF--LVTIIVGVVNFVFTFIAIFL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 299 SDKIGRRPLLMSFGILGTLLTVPLFL--FMKQAHNPVMAFLLMTVGLIIVTGY----TSINAIVKAELFPTEIRALGVGL 372
Cdd:pfam00083 311 VDRFGRRPLLLLGAAGMAICFVILGIvaLLGVSKSDWAGIVAIVFIALFIAFFamgwGPVPWVIVSELFPLSVRSKAMAL 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1207689358 373 PYGLTVaIFGGTAEFIALWL-KSIGHESLFFFYVAGCIAISFLVYWRMGES 422
Cdd:pfam00083 391 ATAANW-LANFLIGFLFPIItDAIGLGYTFFIFAGLLVLFIIFVFFFVPET 440
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
71-418 |
1.61e-28 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 115.86 E-value: 1.61e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17371 49 IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARH 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQIILQNVLSEadmiSWGWRIPFVIGAIGALSVLWLRRTMDESEQFS-KMDSESRENAG 229
Cdd:cd17371 121 RGKALGYVQSGWAVGWLLATLLAALLFPLLPP----EIAWRVLFLLGALPALLVLFIRRFVKEPPQWQaARAARRHFADR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 230 TIKALMKHPKAVLTVIGLTLGGTVA---FYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRP 306
Cdd:cd17371 197 PSLRELFSPPLLRTTLLASLLATGAlggYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 307 LLMsFGILGTLLTVPLFLFMkQAHNPVMAFLLMTVGLiIVTGYTSINAIVKAELFPTEIRALGVGLPYGLTVAIfGGTAE 386
Cdd:cd17371 277 NFA-LFALGSAISILLYFFL-PLSPTLILILGFPLGF-FASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFP 352
|
330 340 350
....*....|....*....|....*....|....
gi 1207689358 387 FIALWLKSIGH--ESLFFFYVAGCIAISFLVYWR 418
Cdd:cd17371 353 FLVGFLATSGSlgTAIAVFAAVYYIAGLVLALLL 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-326 |
1.46e-27 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 111.44 E-value: 1.46e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 4 TSEAANNRRITSNIFKGSVGNLIEWYDWYVYSAFAVYFSSQFfpeGDSTSQLlntAAIFAVGFLMRPIGSLLMGRYADRY 83
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL---GASSAQL---GWIVSAYLLGRAIGLLLFGRLGDRY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 84 GRRAALTLSITIMASGSFIIACTPsygtigllSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLV 163
Cdd:COG0477 77 GRKRVLLIGLLLFGLASLLCGLAP--------SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 164 AGQLVALGVQIILQNVlseadmisWGWRIPFVIGAIGALSVLWLRRTMDeseqfskmdsESRENAGTIKALMKHPKAVLT 243
Cdd:COG0477 149 LGLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLP----------ESRGLLLALLALALAALLLAA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 244 VIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLF 323
Cdd:COG0477 211 LALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
|
...
gi 1207689358 324 LFM 326
Cdd:COG0477 291 LAL 293
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
71-419 |
8.72e-26 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 108.04 E-value: 8.72e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT--------IFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQIILQNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFskmdsesrenagt 230
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 231 ikALMKHPKAVLTVIGLTL-----GGTVAFYTYTTYLQkfmvnSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRR 305
Cdd:cd17359 190 --LVSKGKPILIIGIGLAIfqqfvGINVIFYYGPEIFQ-----NAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 306 PLLM--SFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIV---KAELFPTEIRALGVGLP-YGLTVA 379
Cdd:cd17359 263 PLLLigSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTwvlLSEIFPNRIRGLAMGIAvFFLWIA 342
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1207689358 380 IFGGTAEFIALwLKSIGHESLFFFYVAGCIaISFLVYWRM 419
Cdd:cd17359 343 NFLVSLTFPIL-LAAFGLAFTFLIFAVICV-LAFLFVWKF 380
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-419 |
1.28e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.50 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 61 IFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSAT 140
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 141 YLSEMASSGRRG----FYSSFQYVTLVAGQLVAlgvqiilqNVLSEAdmisWGWRIPFVI-GAIGALSVLWLRRTMDESE 215
Cdd:cd17325 108 LIADIAPPEERGramgIFSSAIGLGFLIGPLLG--------GLLADA----LGYRAPFLVcAALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 216 QFSKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIA 295
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 296 GMLSDKIGRRPLLMsFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTgyTSINAIVkAELFPTEIRALGVGLpYG 375
Cdd:cd17325 256 GKLSDRIGRKPLIL-IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVF--PATLALL-ADIVPPEGRGTAMGL-FN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1207689358 376 LTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVYWRM 419
Cdd:cd17325 331 TAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-417 |
1.92e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.57 E-value: 1.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 21 SVGNLIEWYDWYVYSAFAVYFSSQFfpeGDSTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGS 100
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSF---GLSASQLGLLFALFSLGYA---LLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 101 FIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILqnvl 180
Cdd:cd06174 76 LLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL---- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 181 seADMISWGWRIPFVIGAIGAL----SVLWLRRTMDESEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGTvAFY 256
Cdd:cd06174 144 --ASSLGFGWRAVFLIAAALALlaaiLLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNL-AYY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 257 TYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDK-IGRRPLLMSFGILGTLLTVPLFLFMkqaHNPVMA 335
Cdd:cd06174 221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAP---SLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 336 FLLMTVGLIIVTGYTSINAIVkAELFPTEIRALGVGLpYGLTVAIFGGTAEFIALWLKSIGHE-SLFFFYVAGCIAISFL 414
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALI-AELFPPEIRGTAFGL-LNTFGFLGGAIGPLLAGFLLAATFGlTGAFLVLAVLLLLAAI 375
|
...
gi 1207689358 415 VYW 417
Cdd:cd06174 376 LLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-372 |
2.60e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.71 E-value: 2.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 21 SVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGflmrpIGSLLMGRYADRYGRRAALTLSITIMASGS 100
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYA-----LAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 101 FIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILqnvl 180
Cdd:pfam07690 77 LLLLFASSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL---- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 181 seadMISWGWRIPFVIGAIGALS---VLWLRRTMDESEQFSKMDSESRENAGTIKALMKHPkaVLTVIGLTLGGTVAFYT 257
Cdd:pfam07690 145 ----ASLFGWRAAFLILAILSLLaavLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDP--VLWLLLALLLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 258 YTTYLQKFMvNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFL 337
Cdd:pfam07690 219 LLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLA 297
|
330 340 350
....*....|....*....|....*....|....*
gi 1207689358 338 LMTVGLIIVTGYTSINAIVkAELFPTEIRALGVGL 372
Cdd:pfam07690 298 LLLLGFGFGLVFPALNALV-SDLAPKEERGTASGL 331
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
20-421 |
3.33e-20 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 91.48 E-value: 3.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 20 GSVGNLIEWYDWYVYSAFAVYFSSQFFPEGDSTSQLLnTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASG 99
Cdd:cd17315 2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGL-VVSSLLLGAA---IGSLFGGPLADRFGRRKSLLIAAVLYVIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 100 SFIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNv 179
Cdd:cd17315 78 ALLSALAPNV--------WVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSL- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 180 lseadMISWGWRIPFVIGAIGALSVLWLRRTMDESeqfskmdsesrenagtikalmkhpKAVLTVIGLTL-----GGTVA 254
Cdd:cd17315 149 -----SPPGWWRLMFALAAVPALLQLLLMFFLPES------------------------RALLVGVGLQLlqqltGINAV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 255 FYTYTTYLQKFM-VNSVGLDKGVVSWINFCALLVfvviqpiAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPV 333
Cdd:cd17315 200 MYYAPTIFKSAGgGTASILASIIVGVVNLLATLV-------AIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAK 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 334 MAFLLMTVGLII-----VTGYTSINAIVKAELFPTEIRALGVglpyGLTVAIFGGTAEFIAL----WLKSIGHESLFFFY 404
Cdd:cd17315 273 AAGWLALLGILLyiaafAMGAGPVPWLLLSEIFPLRIRGKGM----AIATLVNWIFNFIVGLtfliMVSTIGLAGVFIFF 348
|
410
....*....|....*..
gi 1207689358 405 VAGCIAISFLVYWRMGE 421
Cdd:cd17315 349 AAVCLLALVFVFFFVPE 365
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
58-416 |
1.51e-19 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 90.40 E-value: 1.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 58 TAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIM-ASGSFIIACTPSYgtigllSPIILVLARLLQGISLGGEYG 136
Cdd:cd17357 54 IVSIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLvVSSLLMFLSKSAK------SPELLIFGRFLVGIACGLSTG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 137 TSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGvqIILQNVLSEADMISWGWRIPFVIGAIGALSVLWL--------- 207
Cdd:cd17357 125 FVPMYLQEISPSELRGALGSLTQIGVTLGILLGQV--FGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFpespkflli 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 208 ----------------RRTMDESEQFSKMDSESREN----AGTIKALMKHP---KAVLTVIGLTLG----GTVAFYTYTT 260
Cdd:cd17357 203 skgdeeeaekslkflrGIEDDVDQELEEIKKESEQMgdqkQVSLMQLLRDPslrLPLLLVLVVSASqqfsGINAIFFYST 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 261 ylqkFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMK-QAHNPVMAFLLM 339
Cdd:cd17357 283 ----FIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFlSEQNSWMSYGCI 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 340 TVGLIIVTGYT----SINAIVKAELFPTEIR--ALGVGLPYGLTVAIFGGTAEFIalwLKSIGHESLFFFYVAGCIAISF 413
Cdd:cd17357 359 VAIFLFIFFFAiglgPIPWFIGAELFPQAPRsaAQSLGSSVNWTSNFIVGMAFPP---LQSIGGGFVFIIFAIPCALFLL 435
|
...
gi 1207689358 414 LVY 416
Cdd:cd17357 436 YLY 438
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
71-341 |
3.12e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 3.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--------LLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSfqyvTLVAGQLVALGVQIILQNVLSEAdmisWGWRIPF-VIGAIGALSVLWLRRTMDESEQFSKMdseSRENAG 229
Cdd:cd17324 121 RGRAIG----LVFSGLTLGLVLGRPLGGLLGQL----LGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPG---SLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 230 TIKALMKHPKAVLTVIGLTLGGTvAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLM 309
Cdd:cd17324 190 SLLLLLRNPRLRLAYLITFLLFG-GFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
250 260 270
....*....|....*....|....*....|..
gi 1207689358 310 SFGILGTLLTVPLFLfmkqAHNPVMAFLLMTV 341
Cdd:cd17324 269 ALLLLAAALLLLTLL----GPSPLLLLVGLVL 296
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
52-415 |
9.51e-18 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 84.64 E-value: 9.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 52 TSQLLNTAAIfaVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSfiIACTPSYGTIGLLSPIILVLARLLQGISL 131
Cdd:cd17364 40 VSGLVNAAAL--VGTI---IGQLFFGFLGDRFGRKRVYGVELIIMIIGT--ILSALSPGSTPLGVMGWLIFFRFLLGIGI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 132 GGEYGTSATYLSEMASSGRRG----FYSSFQYVTLVAGQLVALGVQIILQNVL--SEADMISWGWRIPFVIGAIGALSVL 205
Cdd:cd17364 113 GGDYPLSATIMSEYANKKRRGaliaAVFAMQGFGILAGAIVTLILSAIFEHPLpaGTYHHADLVWRIVLGLGAIPALSVL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 206 WLRRTMdeseqfskmdsesrenAGTikalmkhpkavlTVIGLTLggTVAFYTYTTYlQKFMVNSVGLDKG---------V 276
Cdd:cd17364 193 YFRKHL----------------LGT------------AGTWFLL--DIAFYGQNLF-QSTIISAIGFSKTmnayqelfnI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 277 VSWINFCALLVFVVIQPIAGMLSDKIGRRPL-LMSFGILGTLLTVPLFLFMKQAHNPVMAFLL-MTVGLIIVTGYTSINA 354
Cdd:cd17364 242 AVGQLIIALAGTVPGYWFTVFLIDRIGRKKIqMMGFFGMTIFLLILAGPYDHWKISTIGFFVLyGLTFFFSNFGPNTTTF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207689358 355 IVKAELFPTEIRALGvglpYGLTVA---IFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLV 415
Cdd:cd17364 322 IVPAEVFPARVRSTC----HGISAAsgkIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIIL 381
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
55-224 |
1.49e-17 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 84.75 E-value: 1.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 55 LLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGE 134
Cdd:PRK03893 54 TVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 135 YGTSATYLSEMASSGRRGFYSSFqyvtLVAGQLVALGVQIILQNVLSEAdmisWGWRIPFVIGAIGALSVLWLRRTMDES 214
Cdd:PRK03893 126 YGSSATYVIESWPKHLRNKASGF----LISGFSIGAVVAAQVYSLVVPV----WGWRALFFIGILPIIFALWLRKNLPEA 197
|
170
....*....|
gi 1207689358 215 EQFSKMDSES 224
Cdd:PRK03893 198 EDWKEKHAGK 207
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
71-418 |
4.21e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 83.03 E-value: 4.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYAD----RYGRRAALTLSITIMASGSFI-IACTPSYGTIGLLspIILVLARLLQGISLGGEYGTSATYLSEM 145
Cdd:COG2211 61 ITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFVlLFTAPDLSPTGKL--IYALVTYLLLGLAYTLVNIPYSALGAEL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 146 ASSGR-RGFYSSFQYVTLVAGQLVALGVQIILQNVLSEADmiSWGWRIPFVI-GAIGALSVLWLRRTMDESEQFSKMDSE 223
Cdd:COG2211 139 TPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIfAVLGLLAFLLTFFGTKERPVPEEEKVS 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 224 SREnagTIKALMKHpKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIG 303
Cdd:COG2211 217 LKE---SLKALLKN-RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 304 RRPLLMSFGILGTLLTVPLFLFmkQAHNPVMAFLLMTV-----GLIIVTGYTSINAIVKAELFPTEIRA---------LG 369
Cdd:COG2211 293 KKKAFIIGLLLAALGLLLLFFL--GPGNLWLLLVLAALagiglGAILVLPWAMLADVVDYDEWKTGRRReglyfgiftFA 370
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1207689358 370 VGLPYGLTVAIFGGTAEFIALWLKSIGHES-------LFFFYVAGCIAISFLVYWR 418
Cdd:COG2211 371 IKLGQALAGALAGLLLALFGYVAGAAQSPSaltgirlLFFLLPAVLLLLAALLLLF 426
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
56-415 |
3.09e-16 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 80.36 E-value: 3.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 56 LNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSfiiactpsyGTIGLLSPII-LVLARLLQGISLGGE 134
Cdd:PRK12307 53 MEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGT---------GLSGLASGVImLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 135 YGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVAlgVQIILQnvLSEAdmisWGWRIPFVIGAIGALSVLWLRRTMDES 214
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIGNIIA--AYFMPS--FAEA----YGWRAAFFVGLLPVLLVIYIRARAPES 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 215 EQF--SKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSV--------GLDKGVVSWINFCA 284
Cdd:PRK12307 196 KEWeeAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGLlptylageGFDTGVVSNLMTAA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 285 LLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFlFMKQAHNPVMAFLLMtvGLIIVT-GYTSINAIVKAELFPT 363
Cdd:PRK12307 276 AFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLF-RIPQDNYLLLGACLF--GLMATNvGVGGLVPKFLYDYFPL 352
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1207689358 364 EIRALGVGLPYGLTvAIFGGTAEFIALWLK-SIGHESLFFFYVAGCIAISFLV 415
Cdd:PRK12307 353 EVRGLGTGLIYNLA-ATSGTFNSMAATWLGiTMGLGAALTFIVAFWTATILLI 404
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
61-382 |
9.40e-16 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 78.55 E-value: 9.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 61 IFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSAT 140
Cdd:TIGR00895 57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--------TQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 141 YLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVLseadmiswGWRIPFVIGAIGALSVLW-LRRTMDESEQF-- 217
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF--------GWRSLFYVGGIAPLLLLLlLMRFLPESIDFlv 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 218 -----------SKMDSESRENAGT---------------IKALMKHPKAVLTVI--GLTLGGTVAFYTYTTYLQKFMVNS 269
Cdd:TIGR00895 201 skrpetvrrivNAIAPQMQAEAQSalpeqkstqgtkrsvFKALFQGKTARITVLlwLLYFMLLVGVYFLTNWLPKLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 270 VG-LDKGVVSWINFCALLVFVVIqpIAGMLSDKIGRRPlLMSFGILGTLLTVPLFLfmkQAHNPVMAFLLMTVGLIIVTG 348
Cdd:TIGR00895 281 GFsLSLAATGGALFNFGGVIGSI--IFGWLADRLGPRV-TALLLLLGAVFAVLVGS---TLFSPTLLLLLGAIAGFFVNG 354
|
330 340 350
....*....|....*....|....*....|....*.
gi 1207689358 349 YTSINAIVKAELFPTEIRALGVGLPYGL--TVAIFG 382
Cdd:TIGR00895 355 GQSGLYALMALFYPTAIRATGVGWAIGIgrLGAIIG 390
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
61-371 |
1.56e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.63 E-value: 1.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 61 IFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSAT 140
Cdd:cd17365 39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--------LALLRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 141 YLSEMASSGRRGFYSSFQYVTLVAGQlvalgvqiILQNVLSEADMISWGWRIPFVIGAIGALSVLwlrrtmdeseqfskm 220
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYPLGA--------ALGGFLAAALIPAFGWRSVFLLGGVPPLILL--------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 221 dsesrenagtikalmkhpkaVLTVIGLTLGGT-----VAFYTYTTYLQKFMVnSVGLDKGVVSWINFCALLVFVVIQPIA 295
Cdd:cd17365 168 --------------------PLLRGTLLLWVTffmglLLVYLLNSWLPKLMV-EAGYSLSQALTITLLLNIGGVIGSLLL 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207689358 296 GMLSDKIGRRPLLMSFGILGTLLtvpLFLFMKQAHNPVMAFLLMTV-GLIIVTGYTSINAIVkAELFPTEIRALGVG 371
Cdd:cd17365 227 GWLADRFGPKRVLALFFALGAVS---LALLGVSPASLVLLYVLVFLaGACVNGAQVGLYALA-ARFYPTEVRATGVG 299
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
9-417 |
5.54e-15 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 76.61 E-value: 5.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 9 NNRRITSNIFKGSVGNLIEWYDWYVYSAFAVYFSSQFF-----PEGDSTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRY 83
Cdd:TIGR00879 22 TYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKftsanSDSYSSSLWGLVVSIFLVGGF---IGALFAGWLSDRF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 84 GRRAALTLSITIMASGSFIIACTPsygtiGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLV 163
Cdd:TIGR00879 99 GRKKSLLIIALLFVIGAILMGLAA-----FALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAIT 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 164 AGQLVALGVQiILQNVLSEADmiswGWRIPF----VIGAIGALSVLWL----------------RRTMDESEQFSKMDSE 223
Cdd:TIGR00879 174 FGILVAYGFG-SGKVSLNNTL----GWRIPLglqlIPAGLLFLGLFFLpesprwlvgkgrveeaRKSLARLRGTSGEDKE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 224 SRENAGTIKALMKHPK-------------------AVLTVIGLT----LGGTVAFYTYTTYlqkfMVNSVGLDKGVVSWI 280
Cdd:TIGR00879 249 LLDELELIDIKRSIEKrsvqpswgslfsstrrirrRLFLGVVLQwfqqFTGINAIMYYSPT----IFENAGVSTDHAFLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 281 NFCALLVFVVIQPIAGMLSDKIGRRPLLMsFGILG--------TLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSI 352
Cdd:TIGR00879 325 SIIVGAVNFAFTFVAIFLVDRFGRRPLLL-IGAAGmaiclfvlGILGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPV 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207689358 353 NAIVKAELFPTEIRALgvGLPYGLTVAIFGG--TAEFIALWLKSIGHESLFFFYVAGCIAISFLVYW 417
Cdd:TIGR00879 404 PWVIVSEIFPLSLRPK--GISIAVAANWLANfiVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYF 468
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
55-419 |
7.90e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 75.68 E-value: 7.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 55 LLNTAAIFAVGFLMRPIGSLlmgryADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGE 134
Cdd:cd17474 38 LLITAFTLPAAVLMPVAGVL-----ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL--------LLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 135 YGTSATYLSEMASSGRR----GFYSSFQYVTLVAGQLV--ALGvqiilqnvlseadmiSWGWRIPFVIGAIGALSVLWLR 208
Cdd:cd17474 105 GPLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLggLLA---------------AISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 209 RTMDESEqfSKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVF 288
Cdd:cd17474 170 LFLLPEP--KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 289 VVIQPIAGMLSDK-IGRRPLLMsfgiLGTLLTVPLFLFMKQAHNPVMAFL-LMTVGLIIVTGYTSINAIVkAELFPTEIR 366
Cdd:cd17474 248 ALGSLFVGRLLKKrFGARRILV----IGLLLYALSLLLLGFVPSLALLLIaIVLFGLGLGLNLPLLTTLV-TELAPEEER 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1207689358 367 ALGVGLpYGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVYWRM 419
Cdd:cd17474 323 GTASSL-YNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-350 |
1.82e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 74.52 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 34 YSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSygtig 113
Cdd:cd17477 12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 114 llsPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRG----FYSSFQYVTLVAGQLVAlgvqiilqNVLSEADMIswg 189
Cdd:cd17477 84 ---PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGrvlgLYSTVLGLGFALGPLLL--------ALVGTAGAL--- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 190 wriPFVIGAI----GALSVLWLRRtmdeseqfSKMDSESRENAGTIKALMKHPKAVLTVI--GLTLGGTVAFYTYttYLQ 263
Cdd:cd17477 150 ---PFLIAAVllllALVPLLLTRR--------AAPEIEEAESISLRRLLRIAPLALLGAFvaGFLEGAFYSLLPL--YGL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 264 kfmvnSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMkqAHNPVMAFLLMTVGL 343
Cdd:cd17477 217 -----RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVP--GLPLALLVLLFLWGG 289
|
....*..
gi 1207689358 344 IIVTGYT 350
Cdd:cd17477 290 AAGPLYT 296
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
70-416 |
2.95e-14 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 74.15 E-value: 2.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 70 PIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSG 149
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDV--------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 150 RRGFYSSFQYVTLVAGQLVALgvqiILQNVLSeadmiswgWRIPFVIGAI-----------------------------G 200
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLGY----VLGSFLP--------WRTLALIGAIppvvflillffipesprwlakkgreeeaeK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 201 ALSVLWLRRTMDESE----QFSKMDSESRENAGTIKALMKHP--KAVLTVIGLT----LGGTVAFYTYTTylQKFMVNSV 270
Cdd:cd17358 195 SLQFLRGKDADISKEaaeiQEELAELEKEAKESSFSDLFQRKylKPLVIGLGLMlfqqLSGINAVIFYAS--SIFDEAGS 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 271 GLDKGVVSWINFCALLVFVVIqpiAGMLSDKIGRRPLLM--SFGILGTLLTVPLFLFMKQ-----AHNPVMAFLLMTVGL 343
Cdd:cd17358 273 GLDPNTATIIIGVVQVVGTLV---ATLLVDRLGRRPLLLvsAIGMGIGLLALGLYFYLQEhgallSSVSWLPLVGLVIYI 349
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207689358 344 IIVT-GYTSINAIVKAELFPTEIRALGVGLpygltVAIFGGTAEFIALWL-----KSIGHESLFFFYVAGCIAISFLVY 416
Cdd:cd17358 350 ISFSiGLGPLPWVIMSEIFPAKIKGLAGSL-----VTLVNWLFAFIVTKTfpfltLAWGASGTFWIFAGICGLALVFVL 423
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-419 |
1.08e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.19 E-value: 1.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 51 STSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGIS 130
Cdd:COG0738 41 SDAQAGLLLFAFFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--------LLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 131 LGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVAL-GVQIILQNvlseadmISWGWRIPF-VIGAIGALSVLWLR 208
Cdd:COG0738 110 LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLlGGLLILLG-------LSLSWHLPYlILAVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 209 RTmdESEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTL--GGTVAFYTYTTylqKFMVNSVGLDKGVVSWINFCALL 286
Cdd:COG0738 183 RS--KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLyvGAEGAIGDWLP---LYLKDVLGLSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 287 VFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLtvpLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVkAELFPTEIR 366
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG---LLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA-LDGLGKRTA 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1207689358 367 ALGVGLpygLTVAIFGGTAEFIAL-WLKSIGHESLFFFYVAGCIAISFLVYWRM 419
Cdd:COG0738 334 AAVSAV---LIMGIVGGAIGPPLIgFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
42-411 |
2.18e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 2.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 42 SSQFFPEGDSTSQLLNTA-AIFAVgflmrpIGSLLMGRYADRYGRRAALTLSITIMASGsfiiactpsyGTIGLLSPII- 119
Cdd:cd17473 26 AQHFVPNSELLVPLLLTLpALFIA------LFAPLAGWLADRFGRKRLLIAGLLLYGIG----------GVAGLFLDSLy 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 120 -LVLARLLQGISLGGEYGTSATYLSEMASSGRR----GFYSSFQYV-----TLVAGQLVALGvqiilqnvlseadmiswg 189
Cdd:cd17473 90 aLLASRALLGIGVAGIMTLATALIGDYFEGEERakmlGLQSAAMSLggvvfLLLGGALAEIG------------------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 190 WRIPFVIGAIG----ALSVLWLRRTMDeseqfskmDSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKF 265
Cdd:cd17473 152 WRAPFLVYLLAlpvlILVLLFLPEPAR--------KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 266 MVNSVGLDKGVVSWinfcALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTV---- 341
Cdd:cd17473 224 LQERGGGSAALIGL----ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILaglg 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207689358 342 -GLIIVTGYTSINAIVkaelfPTEIRALGVGlpyGLTVAIFGG--TAEFIALWLKSIGHESLFFFYVAGCIAI 411
Cdd:cd17473 300 fGLLLPTLNSWAMSLV-----PPELRGRAMG---IVTSAFFLGqfLSPLVLGPLVNLTGGLSGAFLILGVLAL 364
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
51-419 |
2.28e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 67.98 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 51 STSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGIS 130
Cdd:cd17319 36 SPTQYGLIASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 131 LGGEYGTSATYLSEMASSGRRGFYSSFQYvtlvAGQLVALGVQIILQNVLSEAdmisWGWRIPFVIgaIGALSVLWLrrt 210
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFN----SGAPLGAAIGPPLSGWLLLL----FGWRWAFII--EGLLGLLLA--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 211 mdeseqfskmdsesrenagtIKALMKHPKAVLTVIGlTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVV 290
Cdd:cd17319 172 --------------------VLWWFYLRQVWGLALG-YFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 291 IQPIAGMLSDKI--GRRPLLmsfGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRAL 368
Cdd:cd17319 231 GMILGGRLSDRLlrGARRLV---IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAAT 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1207689358 369 GVGLpYGLTVAIFGGTAEFIALWLKSIGH-ESLFFFYVAGCIAISFLVYWRM 419
Cdd:cd17319 308 AGGL-INSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLLL 358
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
57-372 |
4.84e-12 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 67.73 E-value: 4.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 57 NTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllsPIILVLaRLLQGISLGGEYG 136
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY-------TVFLVF-RLLVGMGIGGIWV 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 137 TSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQnvlseadmiSWGW-----RIPFVIGAIGAL----SVLWL 207
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP---------DWRWlqlavSLPTFLFFLLSWfvpeSPRWL 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 208 ---------RRTMDESEQFSK-------------MDSESRENAGTIKALMKHP---KAVLTVIGLTLGGTVAFYTYTTYL 262
Cdd:TIGR00898 271 isqgrieeaLKILQRIAKINGkklpaevlslsleKDLSSSKKQYSFLDLFRTPnlrKTTLCLMMLWFTTAFSYYGLVLDL 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 263 QKFMVNsvgldkgvVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFmkqahnPVMAFLLMTVG 342
Cdd:TIGR00898 351 GNLGGN--------IYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFV------PVDLYFLRTAL 416
|
330 340 350
....*....|....*....|....*....|....
gi 1207689358 343 LII----VTGYTSINAIVKAELFPTEIRALGVGL 372
Cdd:TIGR00898 417 AVLgkfgITSAFQMVYLYTAELYPTVVRNLGVGV 450
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
61-371 |
4.91e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 67.29 E-value: 4.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 61 IFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSAT 140
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 141 YLSEMASSGRRGFYSSFQYVTLVAGQLVALGVqiilqNVLSEADMiswGWRIPFVIGAIGAL-SVLWLRRTMDESEQFSK 219
Cdd:PRK11551 127 LTSEAVGPRLRGTAVSLMYCGVPFGGALASVI-----GVLAAGDA---AWRHIFYVGGVGPLlLVPLLMRWLPESRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 220 MDSESRENAGTIKALMKHPKAVLTVIGLT--LGGTVAFYTYTTYLQKFMVnSVGLDKGVVSWI----NFCALLVFVVIqp 293
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGEGRATATLLLWIsyFFTLIVLYFLLNWLPSLLV-GQGLSRSQAGLVqiafNIGGALGSLLI-- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 294 iaGMLSDKIGRRP--LLMSFGILGTLL---TVPLFLFMKQAhnpvmAFLLmtvGLIIVTGYTSINAIVkAELFPTEIRAL 368
Cdd:PRK11551 276 --GALMDRLRPRRvvLLIYAGILASLAalaAAPSFAGMLLA-----GFAA---GLFVVGGQSVLYALA-PLFYPTQVRGT 344
|
...
gi 1207689358 369 GVG 371
Cdd:PRK11551 345 GVG 347
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
59-385 |
5.55e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.81 E-value: 5.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 59 AAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISLGGEYGTS 138
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--------LLLLLVALAGIGSAAFHPEG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 139 ATYLSeMASSGRRGFYSSFqyvTLVAGQL-VALGvqiilqNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMdeSEQF 217
Cdd:cd17478 106 ARLAS-QAAGGRRGLAMSI---FSVGGNLgFALG------PLIAAALVALFGGLGLLILLIIPGLAVALLLLRL--RPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 218 SKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLqKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGM 297
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFL-PFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 298 LSDKIGRRPLLmsfgILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVkAELFPtEIRALGVGLPYGLT 377
Cdd:cd17478 253 LSDRFGRRRVI----IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA-QELLP-GNVGLASGLMMGLS 326
|
....*...
gi 1207689358 378 VAIFGGTA 385
Cdd:cd17478 327 FGLGGIGA 334
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
30-410 |
9.74e-12 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 65.68 E-value: 9.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 30 DWYVYSAFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSY 109
Cdd:cd17317 2 WEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 110 gtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNvlseadmiswg 189
Cdd:cd17317 79 --------ELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD----------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 190 WRIPFVIGAIGALSVLWLrrtmdeseqfskmdsesrenagtikaLMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNS 269
Cdd:cd17317 140 WRWLQLAISLPGLLFLLL--------------------------LWWLPRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 270 VgldkgvvsWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFllMTVGLIIVTGY 349
Cdd:cd17317 194 Y--------LNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTL--ALVGKFAISAA 263
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207689358 350 TSINAIVKAELFPTEIRALGVGLpyGLTVAIFGG-TAEFIALWLKSIGHESLFFFYVAGCIA 410
Cdd:cd17317 264 FSVIYLYTAELYPTVVRNTGVGL--CSTVARVGAiLAPFIVLLGKIGPLLPLIIFGVLALLG 323
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
71-415 |
4.56e-11 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 64.21 E-value: 4.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSygtigllsPIILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPN--------KEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQIILQNVLSeadmiswGWRIPFVIGAIGALSvlwlrrtmdeseQFSKMDS--ESRENA 228
Cdd:cd17360 122 RGRLVTINVLFITGGQFVAYVINGAFSYLPG-------GWRWMLGLAAVPAVL------------QFIGLLFlpESPRWP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 229 GTIKALmkhpkavltVIGLTLG--------GTVAFYTyTTYLQKFMVNSVGLD---KGVVSWINFcallvfvvIQPIAGM 297
Cdd:cd17360 183 STRRAL---------IVGCGLQafqqfsgiNTVMYYS-ATILQMAGFKDNQNAiwlSLIVAGTNF--------IFTIVGM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 298 -LSDKIGRRPLLMS--FGILGTLLTVPLFLFmkqahnpvmaflLMTVGLIIVT---GYTSINAIVKAELFPTEIRALGVG 371
Cdd:cd17360 245 yLIDKFGRRKLLLIslFGVIVALVVLAVWLA------------LVGLILYLAFfapGMGPVPWTVNSEIYPLWARGTGGG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1207689358 372 LPYGLT-VAIFGGTAEFIALwLKSIGHESLFFFY----VAGCIAISFLV 415
Cdd:cd17360 313 CAAAVNwVFNLLVSQTFLTL-TQAIGPYGTFLLFaglaVLGLIFIYFCV 360
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
58-361 |
1.17e-10 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 63.02 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 58 TAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllSPIILVLARLLQGISLGGEYGT 137
Cdd:cd17432 55 TVSIFPLGGL---FGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAK-----SFEMIIVGRFLVGINAGISLNV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 138 SATYLSEMASSGRRGFyssfqyVTLVAGQLVALGV---QII-LQNVLSEADmiswGWriPFVIGAIGALSVL-------- 205
Cdd:cd17432 127 VPMYLGESAPKNLRGA------VGLVPAIFITLGIllgQVLgLRELLGNEE----GW--PLLLALTGVPALLqlltlpff 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 206 ----------------------WLRRTMDESEQFSKMDSESR--ENAGTIKA--LMKHPKA---VLTVI----GLTLGGT 252
Cdd:cd17432 195 pesprylliekgdeeaarkalqRLRGKEDVDDEMEEMLEEQRaeKGVGTVSVleLFRDRSVrwqLISIIvlmaGQQLCGI 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 253 VAFYTYTTYLQKfmvnSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMS-FGILGT---LLTVPLFLfmkQ 328
Cdd:cd17432 275 NAIYFYADSIFL----EAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGgFGLMAVwcaVLTVALSL---Q 347
|
330 340 350
....*....|....*....|....*....|....*..
gi 1207689358 329 AHNPVMAFLLMTVGLIIVTGYTS----INAIVKAELF 361
Cdd:cd17432 348 NTVSWMPYLSIVCIFAYIASFGIgpagVPFILTTEIF 384
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
71-372 |
2.74e-10 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 61.65 E-value: 2.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQIILQNVLSEAdmiswGWRIPFVIGAIGALSVLWLRRTMDESEQFSK---------MD 221
Cdd:cd17437 119 RGFLTSFPEIFINIGILLGYVSNYAFSGLPLHV-----GWRLMLGVGAVPSLFLAIGVLAMPESPRWTPavrrmliaaLG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 222 SESRENAGTIKALMKHPKAVLTVIGLT-----LGGTVAfytyttylqkfmvnsVGLDKGvvswinfcallVFVViqpIAG 296
Cdd:cd17437 194 IHFFQQASGIDAVVLYSPRIFKKAGIKskdklLLATVA---------------VGVTKT-----------LFIL---VAT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 297 MLSDKIGRRPLLM--SFGILGTLLTVPLFLFMKQAHNPVMAFLLmtvGLIIVTGYT----------SINAIVKAELFPTE 364
Cdd:cd17437 245 FLLDKVGRRPLLLtsTGGMTLSLTALATSLTFIDRNGGGLTWAL---VLAITAVCSfvaffsigagPITWVYSSEIFPLR 321
|
....*...
gi 1207689358 365 IRALGVGL 372
Cdd:cd17437 322 LRAQGASL 329
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-418 |
4.40e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.05 E-value: 4.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 51 STSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGIS 130
Cdd:cd17320 32 SASAVQLTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 131 LGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVA--LGVQIilqnvlseadMISWGWRIPFVI-GAIGALSVLWL 207
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAplLGGLL----------LLFFGWRAIFVFlALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 208 RRTMDESEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTLgGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLV 287
Cdd:cd17320 171 LLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGL-SFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 288 FVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKA-ELFPtEIR 366
Cdd:cd17320 250 LILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAlEPFP-HVA 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1207689358 367 ALGVGLPYGLTVAIFGGTAEFIAlWLKSIGHESLFFFYVAGCIAISFLVYWR 418
Cdd:cd17320 329 GTASALLGFLQFLIGALAGALVG-LLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
59-372 |
7.62e-10 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 60.90 E-value: 7.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 59 AAIFAVGFLMRPIGSLLMGRYADRYGRRA--ALTLSITIMASgsfiIACTPSYGTIGLLSPIILVLARLLQGISLGGEYG 136
Cdd:TIGR00887 59 AAVNGSASIGTLAGQLFFGWLADKLGRKRvyGMELIIMIIAT----VASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 137 TSATYLSEMASSGRRGFYSS----FQYVTLVAGQLVALGVQIILQNVL-----------SEADMISWGWRIPFVIGAIGA 201
Cdd:TIGR00887 135 LSAIITSEFATKKWRGAMMAavfaMQGFGILAGAIVALIVLAGFKHSLeaaadeasctgSCVPAVDYMWRILIGFGAVPA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 202 LSVLWLRRTMDESEQFS-------KMDSESRENAGTIKA------LMKHPKAVLTVI---------------GLTLGGT- 252
Cdd:TIGR00887 215 LLALYFRLTIPETPRYTadvakdvEQAASDMSAVLQVKIeaepdeVEKASTAVEVPKaswsdffthffkwrhGKHLLGTa 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 253 -------VAFYTYTTYlQKFMVNSVGL---DKGVVSWINFCALLVFVVIQPIAG---------MLSDKIGRRPL-LMSFG 312
Cdd:TIGR00887 295 gswflldIAFYGVNLN-QKVILSAIGYsppAATNNAYEELYKTAVGNLIIALAGtvpgywvtvFLVDIIGRKPIqLMGFF 373
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207689358 313 ILGTLLTVPLFLFMKQAHNpvmAFLLMTVGLIIVT--GYTSINAIVKAELFPTEIRALGVGL 372
Cdd:TIGR00887 374 ILTVLFFVLGFAYNHLSTH---GFLAIYVLAQFFAnfGPNATTFIVPGEVFPTRYRSTAHGI 432
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
71-372 |
9.03e-10 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 60.06 E-value: 9.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQIILQNVLseadmisWGWRIPF----VIGAIGALSVLWLrrtmdeseqfskmDSESRE 226
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAFADVV-------GGWRYMYglaaPPALLLGIGMWFL-------------PPSPRW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 227 NAGTIKALMkhpkavltvIGLTLggtVAFYTYT-----TYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQP-IAGMLSD 300
Cdd:cd17362 186 QGNYRKPLI---------IGLGL---VLFQQITgqpsvLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTiVAVLLVD 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207689358 301 KIGRRPLLM--SFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYT----SINAIVKAELFPTEIRALGVGL 372
Cdd:cd17362 254 KLGRRPLLLggVSGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQisfgPISWLMVSEIFPLRVRGRAIAL 331
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
36-416 |
1.15e-09 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 59.96 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 36 AFAVYFSSQFFPEGDSTSQLLNTAAIFAVGFLMrpiGSLLMGRYADRYGRRAALTLSITIMASGsFIIACTpSYGTIGLL 115
Cdd:cd17356 28 SFQKYFADNTGTYYPSSSRQGLIVSIVNLGSFF---GALISSFLSDRIGRKKSIQIGCVIYIIG-AIIQVA-AIGKWYQL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 116 spiilVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVLSEADmiswgWRIPFV 195
Cdd:cd17356 103 -----IVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 196 IGAIGALSVL-----------WLRRTMdeseqfskmdsesrenagtikalmkhpKAVLTVIGLTLGGTVAFYTYTTYlqk 264
Cdd:cd17356 173 LQIVWGLLLLigmfflpesprWLYRTI---------------------------LGIMLQLFQQLTGINYFFYYGTT--- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 265 fMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLM--SFGILGTLLTVPLFLFMKQAHNP---------- 332
Cdd:cd17356 223 -IFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLigAAGMSICLFIYAAVGVRYLIPNPqsgtsnksag 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 333 -VMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLpygltVAIFGGTAEF-IALW----LKSIGHeSLFFFYVA 406
Cdd:cd17356 302 nGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMAL-----ATAFNWLWNFlISFFtpfiIGSIGF-KYYYIFAG 375
|
410
....*....|
gi 1207689358 407 GCIAISFLVY 416
Cdd:cd17356 376 CNLLAFIVVF 385
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
4-366 |
1.56e-09 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 59.71 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 4 TSEAANNRRITSNIFKGSVGNLIEWYDWYVYSAF-----AVYFSSQFFPEGDSTSQLLNTAAIFAVGFLmrpIGSLLMGR 78
Cdd:PRK10077 1 MNTQYNSSYIFSITLVATLGGLLFGYDTAVISGTveslnTVFVAPQNLSESAANSLLGFCVASALIGCI---IGGALGGY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 79 YADRYGRRAALtlsitIMASGSFIIACTPSY-----------GTIGLLspIILVLARLLQGISLGGEYGTSATYLSEMAS 147
Cdd:PRK10077 78 CSNRFGRRDSL-----KIAAVLFFISALGSAwpefgftsigpDNTGYV--PEFVIYRIIGGIGVGLASMLSPMYIAEIAP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 148 SGRRGFYSSFQYVTLVAGQLVALGVQIILQNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDES-------EQFSKM 220
Cdd:PRK10077 151 AHIRGKLVSFNQFAIIFGQLVVYFVNYFIARSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETprylmsrGKQEQA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 221 DSESRENAGT---------IKALMKHPK----------AVLTVIGLTL-------GGTVAFYtYTTYLQKFM---VNSVG 271
Cdd:PRK10077 231 EGILRKIMGNtlatqalqeIKHSLDHGRktggkllmfgVGVIVIGVMLsvfqqfvGINVVLY-YAPEIFKTLgasTDIAL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 272 LDKGVVSWINfcalLVFVVIqpiAGMLSDKIGRRPLLMSFGI---LGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTG 348
Cdd:PRK10077 310 LQTIIVGVIN----LTFTVL---AIMTVDKFGRKPLQIIGALgmaIGMFSLGTAFYTQAPGIVALLSMLFYVAAFAMSWG 382
|
410
....*....|....*...
gi 1207689358 349 ytSINAIVKAELFPTEIR 366
Cdd:PRK10077 383 --PVCWVLLSEIFPNAIR 398
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-394 |
1.48e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.48 E-value: 1.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 22 VGNLIEWYDWYVYSAFAVYFSSqFFPEGDSTSQLLNTAaiFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSF 101
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQS-DFLIDDSLAGLLQTV--FIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 102 IIACTPSYgtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVLS 181
Cdd:cd17328 80 LSSFAPNF--------WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 182 eadmiswGWRIPFVI-GAIGALSVLWLRRTMDE-----SEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTlggTVAF 255
Cdd:cd17328 152 -------GWRWAFRVtGVLGVLLAILLLLFVREpprgaAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFT---AVSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 256 YTYT------TYLQKFMVNSvGLDKGVVSWINFCALLVFVVIQPIAG-MLSDKIGR-----RPLLMSFGILGtlLTVPLF 323
Cdd:cd17328 222 VTGAlafwapTFFLRAFGVG-DLSSADVGLIFGAITCIAGVLGVLLGgILADRLRRktpraDPLVCAVGLLA--AAPFLF 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207689358 324 LFMKQAHNPVMAFLLMtvGLIIVTGYTSINAIVKAELFPTEI---RALGVGLpYGLTVAIFGGTAEFIALWLKS 394
Cdd:cd17328 299 LALVLALSNLLLAWVL--LFLGEFLLSLNWAPVFAILLYVVIptrRSTASAI-QILLSHLLGDAGSPYLIGLIS 369
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
71-417 |
1.14e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.40 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTIGLLspiiLVLArllqGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVL----LFLV----GAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVAlgvQIILQNVLSEAdmiswGWRIPFVIGAI-----GALSVLWLRrtmdESEQFSKMDSESR 225
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALA---AALLPPLALHY-----GWRAAFVVAGLvsilaAVLFWLFYR----EPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 226 ENAGTIKALMKHPKAVLTVI-GLTLGGtvAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKI-- 302
Cdd:cd17475 186 TLLRSLKEVLRNRDVWLIAIaGALLVA--PQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfg 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 303 GRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGLT-VAIF 381
Cdd:cd17475 264 GRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINfIGIA 343
|
330 340 350
....*....|....*....|....*....|....*.
gi 1207689358 382 GGTAEFIALwLKSIGHESLFFFYVAGCIAISFLVYW 417
Cdd:cd17475 344 IGPPLFGLL-VDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
51-343 |
3.34e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.18 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 51 STSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPsygtigllSPIILVLARLLQGIS 130
Cdd:cd17321 29 SPSQLQWVVNAYLLAFA---ALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP--------SLAFLIAARALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 131 LGGEYGTSATYLSEMASSGRR----GFYSSFQYVTLVAGQLVAlgvQIILQNvlseadmISWGWrIPFVIGAIGALSVLW 206
Cdd:cd17321 98 AAAIMPASLALIAATFPGERRgralGLWGAVVGIGAALGPLLG---GLLLEL-------FGWRW-IFLINVPIGLVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 207 LRRtmdeseqFSkmdsesrenagtikalmkhpKAVLTVIGLTLGGTVAFYTYTTYLQKFMvnsvGLDKGVVSWINFCALL 286
Cdd:cd17321 167 ART-------FS--------------------GAVLAAFLLGAALGGLLFLLPLYLQGVL----GYSPLQAGLALLPLAL 215
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1207689358 287 VFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGL 343
Cdd:cd17321 216 AMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGL 272
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
71-419 |
5.24e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 5.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGsfiiactpsYGTIGLL-SPIILVLARLLQGISLGGEYGTSATYLSEMASSG 149
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALG---------FALLGFAhSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 150 RRGFYSSFQYVTLVAGqlVALGvqIILQNVLSEADMiswgwRIPFVIGAI-----GALSVLWLRRTMDESEQFSKMDSES 224
Cdd:cd17329 121 NRTRAFSLLYWAINLG--VAIG--PLLGGLLLLYSF-----RLLFLAAAVlfllaALVLLFLLPETRPKRRAAEKTEILR 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 225 RenagtiKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGR 304
Cdd:cd17329 192 G------YKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 305 RPLLMsfgiLGTLLTVPLFLFMKQAHNPVMAFLLM---TVGLIIVTgyTSINAIVkAELFPTEIRALGVGLpYGLTVAIF 381
Cdd:cd17329 266 RKILM----IGILLFAIGFAVLAFANTLAVLILAMivlTLGEMLVF--PAVQTLV-AALAPPDKRGSYMGF-YALAWGLG 337
|
330 340 350
....*....|....*....|....*....|....*...
gi 1207689358 382 GGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVYWRM 419
Cdd:cd17329 338 RAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
63-417 |
5.72e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 5.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 63 AVGFLMRPIGsllmGRYADRYGRRAALTL---SITIMASgsFIIACTPSYGTIGLLSpiilVLARLLQGISlggeygTSA 139
Cdd:cd17370 45 ALGSLLRLFS----GYLSDRTGKRKPLVIlgyGLSALAK--PLLALAGSWQLVLLLR----ILERLGKGIR------TPP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 140 --TYLSEMASSGRR----GFYSSFQYVTLVAGQLVALGVQIILQNVLSEADMISwgwripFVIGAIGALSVLWLRRTMDE 213
Cdd:cd17370 109 rdALLADATPPSGRgkafGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLA------AIPALLALLILLFVVKEYPR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 214 SEQFSKMDSESRenagtikaLMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWInfCALLVFVVIQP 293
Cdd:cd17370 183 PPKLRKKSKKTS--------LKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYA--LFNLVYALAAY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 294 IAGMLSDKIGRRPLLMsFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSinAIVkAELFPTEIRALGVGLp 373
Cdd:cd17370 253 PAGRLSDRIGRKKLLI-LGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIER--AAV-ADLVPAELRGTAYGL- 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1207689358 374 YGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVYW 417
Cdd:cd17370 328 FNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
71-194 |
6.17e-07 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 51.34 E-value: 6.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17435 51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYT--------VLIVGRIAIGVSISLSSIATCVYIAEIAPQHR 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQIILQNVlseadmiSWGWRIPF 194
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYISNYAFANV-------SNGWKYMF 159
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
58-417 |
7.92e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.06 E-value: 7.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 58 TAAIFAVGFLMRPigslLMGRYADRYGRRAALTLSITIMASGSFIiactpsYGTIGllSPIILVLARLLQGISLGGEYGT 137
Cdd:cd17489 37 VGLFTLAALLARP----FAGRLLDRFGRKRLLLIGLLIFALATLL------YLLAT--SVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 138 SATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNVLSEADMISwgwrIPFVIGAIGALSVLWLRRTmdeseqF 217
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI----VAAVLALLALLLVFLVKDP------P 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 218 SKMDSESRENAGTIKALMKhpKAVLTVIGLTLGGTVAFYTYTTYLQKFMvNSVGLDKGVVSWINFCalLVFVVIQPIAGM 297
Cdd:cd17489 175 PVAAEEAEAGTRAFRRLVE--KKVLPPALILFLASIAYGAISTFLPLYA-AERGISNAGLFFTVYA--IALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 298 LSDKIGRRPLLMSFGILGTLLTVPLFlfmkQAHNPVMAFLlmtVGLIIVTGYTSINAIVKAELF---PTEIRALGVG--- 371
Cdd:cd17489 250 LSDRKGPKTVIIPGLLLLALGLLLLS----FAGSPWMLLL---AAVLYGLGFGLLFPALQALAVdlvPPHRRGAANGtff 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1207689358 372 ----LPYGLTVAIFGGTAEfialwlkSIGHESLFFFyVAGCIAISFLVYW 417
Cdd:cd17489 323 iffdLGIGLGGLLLGLVAE-------LFGYRAMFLL-AAVVVLLALVLYI 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
242-420 |
1.94e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.48 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 242 LTVIGLTLGGTVAFYTYTT--YLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLmsfgILGTLLT 319
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNlsVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL----AIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 320 VPLFLFMKQAHNPVMAFLLMT-VGLIIVTGYTSINAIVkAELFPTEIRALGVGLpYGLTVAIFGGTAEFIALWL-KSIGH 397
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFlLGLGEAGFFPAALKLI-AEWFPPKERGRALGI-FNAGGPLGGALAPPLLGWLlAAFGW 163
|
170 180
....*....|....*....|...
gi 1207689358 398 ESLFFFYVAGCIAISFLVYWRMG 420
Cdd:COG2271 164 RAAFLILGLPGLLLALLRFWLLA 186
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
31-348 |
2.37e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 49.22 E-value: 2.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 31 WYVYSAFAVYFSSQFFpeGDSTSQLLNTAAI-FAVGFLMRpigsLLMGRYADRYGRRAALTLSITIMAsgsfiIACTpsY 109
Cdd:TIGR00886 17 WFAFSPLAVFLIKDDL--GLSTAQLGNLVAVpVLAGAVLR----IILGFLVDIFGPRYTTALSLLLLA-----IPCL--W 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 110 GTIGLLSPIILVLARLLQGISLGgeygtsaTYLSEMASSGRrgFYSSFQYVT---LVAG---------QLVALGVQIILQ 177
Cdd:TIGR00886 84 AGLAVQSYSVLLLIRLFIGIAGG-------SFASCMPWISF--FFPKKIQGTalgLAAGwgnmgggvaQFVMPPIIGSLI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 178 NVLSEADMISWGWRIPFVIGAIGALSVLWLrrtmdeseqFSKMDSESRENAGTIKALMKHPKAVLT-----VIGLTLGGT 252
Cdd:TIGR00886 155 FGGGQPAHLAWGWAFVIVPAGILLLPALLI---------FFVGADTPPGKPATGKLSFKEALKVFGnrhtwILALLYSVT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 253 V-AFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIG-RRPLLMSFgiLGTLLTVPLFLFMKQAH 330
Cdd:TIGR00886 226 FgSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGgARKLLMNF--LGVAMGAFLVVLGLVSD 303
|
330
....*....|....*...
gi 1207689358 331 NPVMAFLLMTVGLIIVTG 348
Cdd:TIGR00886 304 GSLAAFIVLFVALFFFAG 321
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
58-364 |
2.97e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.19 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 58 TAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSygtigllSPIILVLARLLQGISLGGEYGT 137
Cdd:cd17355 40 ISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS-------LWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 138 SATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGvqiilqnvLSEADMISWGWRIPFVIGAIGAL-----SVLWLRRTMD 212
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLP--------LGAALIEAFGWRTALLVLALLALlvlvpVLLLLRRRPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 213 ESEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGtVAFYTYTTYLQKFMVNsVGLDKGVVSWInFCALLVFVVI- 291
Cdd:cd17355 185 DLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCG-FAVVGLIVHLVPYLAD-RGISPAAAAVA-LALIGLFNIVg 261
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207689358 292 QPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAhnPVMAFLLMTVGLiIVTGYTSINAIVKAELFPTE 364
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPP--LALLLFAALFGL-GWGATVPLTAALAARYFGAR 331
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
249-353 |
5.06e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 5.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 249 LGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIG-----RRPLLMSFGILGTLLTVplF 323
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFV--L 97
|
90 100 110
....*....|....*....|....*....|.
gi 1207689358 324 LFMKQAHNPVMAFLLMTVGLIIV-TGYTSIN 353
Cdd:COG2211 98 LFTAPDLSPTGKLIYALVTYLLLgLAYTLVN 128
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
50-419 |
5.48e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 5.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 50 DSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTIGLlsPIILVLArLLQGI 129
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSL--WLLLVLA-FLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 130 SLGGEYGTSATYLSEMASSGRR----GFYSSFQYVTLVAGQLVAlGVQIILqnvlseadmisWGWRIPFVIGA----IGA 201
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQLvranALNSLATQLARIIGPALG-GLLVAL-----------LGPGGAFAINAlsflLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 202 LSVLWLRRTMDESEQFSKmDSESRENAGTIKALMKHPKAVLTVIGLTLGGTVAFyTYTTYLQKFMVNSVGLDKGVVSWIN 281
Cdd:cd06173 173 LLLLFIRRPPPAAPGESS-SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGG-ALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 282 FCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFmkqAHNPVMAFLLMTVGLIIVTGYTSINAIVkAELF 361
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLL-QLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1207689358 362 PTEIRALGVGLpYGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVYWRM 419
Cdd:cd06173 327 PDELRGRVFSV-YNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
53-372 |
6.14e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 48.06 E-value: 6.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 53 SQLLNTAA--IFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllsPIILVLaRLLQGIS 130
Cdd:cd17374 33 SQSLKSVAqsIFMAGLL---VGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF-------PVYCVL-RFLAGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 131 LGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNvlseadmiswgWRIPFVIGAIGALSVLWLRRT 210
Cdd:cd17374 102 VSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRD-----------WRLLQLVVSVPFFLFFLYSWW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 211 MdeseqfskmdsesrenagtikalmkhPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVNsVGLDKGVVSWINFCA-LLVFV 289
Cdd:cd17374 171 L--------------------------PKRTLILSFVWFANSFSYYGLSLDLQHLGLN-VFLLQFLFGAVEVPArCLALF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 290 VIQpiagmlsdKIGRRPLLMSFGIL-GTLLTVPLFLfmkQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRAL 368
Cdd:cd17374 224 LLN--------HMGRRISQAVLLLLaGLCILANIFV---PQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQT 292
|
....
gi 1207689358 369 GVGL 372
Cdd:cd17374 293 GMGL 296
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
51-372 |
1.04e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.57 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 51 STSQLLNTAAIFAVGfLMRPIGSLLmgryADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGIS 130
Cdd:cd17503 31 DTVQWVITSYLLALA-IMIPLSGWL----ADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 131 LGGEYGTSATYLSEMASSGRRGFYSSFqyVTLVAgqLVALGVQIILQNVLSEAdmISWGW----RIPFVIGAIGALSVLW 206
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGL--VGLVI--LLAPAIGPTLGGWLTDN--LSWRWifyiNLPIGILALLLAPLLD 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 207 LRrtmdeseqfskmdsesrenagtikaLMKHPKAVLTVIGLTLGGtVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALL 286
Cdd:cd17503 172 LR-------------------------LFKDRNFTLGLLLSFLLG-LGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 287 VFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELfPTEIR 366
Cdd:cd17503 226 ASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSL-PPEQI 304
|
....*.
gi 1207689358 367 ALGVGL 372
Cdd:cd17503 305 GDATAL 310
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
71-366 |
1.17e-05 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 47.10 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17436 51 LASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSF--------FWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQIILQNVLseadmisWGWRIPF----VIGAIGALSVLWLRRTMDESEQFSKMDSEsre 226
Cdd:cd17436 123 RGLLVSLYEAGITVGILISYALNYFFSNVL-------TGWRYMFglaiIPAAIQFASILLLPKKPEVLNIKDNMRRR--- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 227 nagtikalmkhpkavlTVIGLtlgGTVAFYTYT-----TYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGM-LSD 300
Cdd:cd17436 193 ----------------TLVGL---GLVLFQQFTgqpnvLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMlFAD 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207689358 301 KIGRRPLL------MSFGILGTLLTVPLFLFMKQahnpVMAFLLmtvgliivtGYTSINAIVKAELFPTEIR 366
Cdd:cd17436 254 RAGRRSLLiagcsvMAVSVSGIGLWITLLCLMAF----VSAFSI---------GFGPMTWLVLSEIYPADIR 312
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
71-217 |
2.05e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 46.89 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:TIGR01299 217 VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYFAEFLAQEK 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQ-IILQNVLSEADMIS----WGWRIPFVIGAIGALSVLWLRRTMDESEQF 217
Cdd:TIGR01299 289 RGEHLSWLCMFWMIGGIYAAAMAwAIIPHYGWSFQMGSayqfHSWRVFVIVCAFPCVFAIGALTFMPESPRF 360
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
71-217 |
2.33e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 46.45 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVqiilqnVLSEADMISWG-----------WRIPFVIGAIGALSVLWLRRTMDESEQF 217
Cdd:cd17438 121 RGEHLSWLCMFWMIGGLYASAM------AWSIIPHYGWGfsmgtnyhfhsWRVFVIICALPCIASIIALKFMPESPRF 192
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
60-361 |
2.38e-05 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 46.56 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 60 AIFAVGFLmrpIGSLLMGRYADRYGRRAALtLSITIMAsgsFIIACTPSYGTIGlLSPIILVLARLLQGISLGGEYGTSA 139
Cdd:cd17431 57 AIFSVGGM---IGSFSVGLFVNRFGRRNSM-LYNNLLA---FAGAALMGLSKLA-KSYEMLILGRFIIGLYCGLTTGLVP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 140 TYLSEMASSGRRGFYSSFQYVTLVAGQLVA--LGVQIILQNvlseadmiSWGWriPFVIGAIGALSVLW----------- 206
Cdd:cd17431 129 MYIGEISPTALRGALGTLHQLGIVVGILISqiFGLEFILGT--------EELW--PLLLGFTIVPAILQlallpfcpesp 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 207 -------------------LRRTMDESEQFSKMDSESR----ENAGTIKALMKHPK-------AVLTVIGLTLGGTVAFY 256
Cdd:cd17431 199 ryllinrneeeeaksvlkkLRGTTDVSEDIQEMKEESRqmmrEKKVTILELFRSSSyrqpiiiAIVLQLSQQLSGINAVF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 257 TYTTYLqkFMVNSVG------LDKGVVSWInFCALLVFVViqpiagmlsDKIGRRPL----LMSFGILGTLLTVPLFLFM 326
Cdd:cd17431 279 YYSTSI--FEKAGVQqpvyatIGAGVVNTI-FTVVSLFLV---------ERAGRRTLhligLGGMAICAILMTIALLLLE 346
|
330 340 350
....*....|....*....|....*....|....*....
gi 1207689358 327 KQahnPVMAFLLMTVGLIIV----TGYTSINAIVKAELF 361
Cdd:cd17431 347 GY---PWMSYVSIVAIFGFVaffeIGPGPIPWFIVAELF 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
247-417 |
3.07e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 3.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 247 LTLGGTVAFYTYTTY--LQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFL 324
Cdd:cd06174 1 LLLGFFLTGLARGLIspLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 325 fmkqAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLpYGLTVAIFGGTAEFIALWLKSIGHESLF-FF 403
Cdd:cd06174 81 ----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRaVF 155
|
170
....*....|....
gi 1207689358 404 YVAGCIAISFLVYW 417
Cdd:cd06174 156 LIAAALALLAAILL 169
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
71-372 |
3.81e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 45.70 E-value: 3.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLsitimASGSFIIActpsyGTIGLLSPII--LVLARLLQGISLGGEYGTSATYLSEMASS 148
Cdd:cd17361 66 VASLLASYVTRKWGRKPSMLI-----GGVLFLVG-----AALNAAAQNIamLIVGRILLGFGVGFGNQAVPLYLSEMAPA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 149 GRRG-FYSSFQYVTLVaGQLVAlgvQIILQNVlseADMISWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKMdsesren 227
Cdd:cd17361 136 KLRGaLNIGFQLAITI-GILIA---NLINYGT---SKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQL------- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 228 agTIkalmkhpkAVLTVIGLTLGG--TVAFYTyttylqKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRR 305
Cdd:cd17361 202 --VI--------AILIPFFQQLTGinVIMFYA------PVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRR 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207689358 306 PLLMSFGILGTL--LTVPLFLFMKQAHNPVM----AFLLMTVGLIIVTGY----TSINAIVKAELFPTEIRALGVGL 372
Cdd:cd17361 266 FLLLEGGVQMLAsqVAIGILLAVKFGDGGELpkayAIAVVVLICLYVAAFawswGPLGWLVPSEIFPLETRSAGQSL 342
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
194-356 |
5.52e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 45.18 E-value: 5.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 194 FVIGAIGALSVLWL----------------RRTMDESEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTLgGTVAFYT 257
Cdd:cd17337 148 FTIPVIGEIGTLWLslvfvalgglialflvRDRTGEQPLANPSEEPLKELLSGITILFRNPKIAIGGIVRII-NTLSQFG 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 258 YTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQA--HNPVMA 335
Cdd:cd17337 227 FPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLLFYYVPQLfgHNYWAA 306
|
170 180
....*....|....*....|.
gi 1207689358 336 FLLMTVGLIIVTGYTSINAIV 356
Cdd:cd17337 307 LIAAILFGIGLAGFVPLSALM 327
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
60-205 |
6.30e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 42.64 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 60 AIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISLGGEYGTSA 139
Cdd:TIGR00880 5 AGYALGQL---IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNIT--------VLIIARFLQGFGAAFALVAGA 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207689358 140 TYLSEMASSGRRGFYSSFqyvtLVAGQLVALGVQIILQNVLSEAdmisWGWRIPFVIGAIGALSVL 205
Cdd:TIGR00880 74 ALIADIYPPEERGVALGL----MSAGIALGPLLGPPLGGVLAQF----LGWRAPFLFLAILALAAF 131
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
66-356 |
6.89e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.88 E-value: 6.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 66 FLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQGISlGGEYGTSATYLSEM 145
Cdd:cd17504 41 LLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP--------VLIAGRALQGIG-GAVFPLAFALVREE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 146 ASSGRRGFYSSFQYVTLVAGQLVALgvqiILQNVLSEAdmisWGWRIPFVIGAIGALSVLWLRRTMDeseqfskmdsesr 225
Cdd:cd17504 112 FPPERVPVAQGILSATFGIGAGIGL----PLGGWIVQH----LGWRWIFWTAAPVAVLLAALVPLID------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 226 enagtIKALMKHPKAVLTVIGLTLGGT--VAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIG 303
Cdd:cd17504 171 -----LRLLRRRNVLLANITALLAGFGmfMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1207689358 304 RRPLLmsfgILGTLLTVPLFLFMkqAHNPVMAFLLMTVGLIIVTGYTSINAIV 356
Cdd:cd17504 246 PRRVL----LIGLVISAVGLLLL--ALLHSSLWALVVALLLIGIGLGLAFASL 292
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
58-153 |
7.54e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 44.65 E-value: 7.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 58 TAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGT 137
Cdd:cd17379 38 FQSSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMT 106
|
90
....*....|....*.
gi 1207689358 138 SATYLSEMASSGRRGF 153
Cdd:cd17379 107 GYVLVTEFVGSKYRRT 122
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
81-349 |
1.00e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 44.53 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 81 DRYG------RRAALTLSITIMASGSFIIACTPSYGTIGLLSPIILVLARL--LQGISLGGeygtsatYLSEMASSGRRG 152
Cdd:cd17485 55 DRYGlprlgrRRSWLLPTQLGLALLLLALAFLPPTTNLLAFLGLLFLLNLFsaTQDIATDG-------LAVELLTPEERG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 153 FYSSFQYVTLVAGQLVALGVQIILQNVlseadmisWGWRIPFVIGAI----GALSVLWLRRtmDESEQFSKMDSESRENA 228
Cdd:cd17485 128 LGNAAQVVGYKLGSLLGGGGLLWLYDL--------IGWQSLLLSLAAlyllLLLPVLFLRE--LELPQQPPASERGAALK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 229 GTIKALMKHPKA---VLTVIGLTLGGTVAFYTYTTYL--QKFMVNSVGLDKGVVSwinfcaLLVFVVIQPIAGMLSDKIG 303
Cdd:cd17485 198 ASLRAFLRRPGTrwlLLFLLLYKLGEQGALAMLPPFLvdRGFSLSQIGLLSGVGG------SLVSIAGSLLGGYLLKRRG 271
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1207689358 304 RRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGY 349
Cdd:cd17485 272 RRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGG 317
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
31-348 |
1.03e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.16 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 31 WYVYSAFAVYFSSQFfpeGDSTSQLLNTAAI-FAVGFLMRpigsLLMGRYADRYGRRaaltlSITIMASGSFIIACTpsY 109
Cdd:cd17341 15 WFLFAPLGPVIRDDL---GLSTSQIGLLVAIpVLAGALLR----LPYGFLCDRFGGR-----RVFIASLLLLLIPLL--A 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 110 GTIGLLSPIILVLARLLQGISLggeygtsATYLSEMASSGRrgFYSSFQYVTLVAGQ---------LVALGVQIILQNVL 180
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAG-------ANFASGQPWASF--WFPKEKIGGAAGGIagagnmgvaVSQLLAPLIAGAIV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 181 SEADMISWGW--RIPFVIGAIGALSVLWLRRTMDESeqfskmDSESRENAGTIKALMKHPKAVLTVI--GLTLGGTVAFy 256
Cdd:cd17341 152 FDGGFVGWRNafFVPGILLAIAAVLVLLFGDDLPTG------KASALEFLKVQLAVLKNYRTWILSLlyGVTFGSFVGF- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 257 tyTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAF 336
Cdd:cd17341 225 --SNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLF 302
|
330
....*....|..
gi 1207689358 337 LLMTVGLIIVTG 348
Cdd:cd17341 303 LALFVALGLGAG 314
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
282-421 |
1.70e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 282 FCALLVFVVIQPIAGMLSDKIGRRPlLMSFGILGTLLTVPLFLFmkqAHNPVMAFLLMTV-GLIIVTGYTSINAIVkAEL 360
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKR-LLLIGLLIFALATLLYLL---ATSVALLLVLRLIhGIGWGAFTTAAATLV-ADI 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207689358 361 FPTEIRALGVGLpYGLTVAIFGGTAEFIALWLKSIGHESLFFFYVAGCIAISFLVYWRMGE 421
Cdd:cd17489 113 IPPSRRGEGIGY-YGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKD 172
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
71-419 |
2.10e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 43.32 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17502 45 AFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTLVAGQLVAlgvqIILQNVLSEadmiSWGWRIPFVIG-AIGALSVLWLRrtmdeseqfskmdsesrenag 229
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAG----PLIGGAFTD----HLSWRWCFYINlPIGGLALALLR--------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 230 TIKALMkhpkavltVIGLTLGGtvAFYTYTTYLQKFMVNSVGlDKGVVSWINFCALLVFVVIQP-IAGMLSDKIGRRPLL 308
Cdd:cd17502 168 TILLSS--------IFGFLFGG--ALFGLIYYLPLYFQLVLG-DSATKSGVRLLPLIIGLVIGSiISGALISKTGRYKPL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 309 MSFG-ILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIralgvglPYGLTVAIFG---GT 384
Cdd:cd17502 237 IVIGtILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADV-------GVATATNTFFrslGG 309
|
330 340 350
....*....|....*....|....*....|....*
gi 1207689358 385 AEFIALWlksighesLFFFYVAGCIAISFLVYWRM 419
Cdd:cd17502 310 TLGVAIT--------DVFLVALALAALAFLLSLFL 336
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
71-217 |
2.20e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 43.48 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207689358 151 RGFYSSFQYVTLVAGQLVALGVQ-IILQNVLSEADMIS----WGWRIPFVIGAIGALSVLWLRRTMDESEQF 217
Cdd:cd17439 121 RGEHLSWLCMFWMIGGIYASAMAwAIIPHYGWSFQMGSayqfHSWRVFVLVCAFPSVFAIGALTTMPESPRF 192
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
71-152 |
3.82e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 42.86 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTigllspiiLVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:cd17363 49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGF--------FLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
|
..
gi 1207689358 151 RG 152
Cdd:cd17363 121 RG 122
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
269-424 |
4.94e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 42.18 E-value: 4.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 269 SVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLMsFGILGTLLTVPLFLFmkqAHNPVMAFLLMTVGLIIVTG 348
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL-LGLLLLAVSTLLFAF---ATSYWQLLLARFLQGLASAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 349 YTSINAIVKAELFPTEIRA-----LGVGLPYGLTV-AIFGGtaeFIALWLksiGHESLFFFYVAGCIAISFLVYWRMGES 422
Cdd:cd17325 101 VWPAAMALIADIAPPEERGramgiFSSAIGLGFLIgPLLGG---LLADAL---GYRAPFLVCAALALLALVLALLLLPEP 174
|
..
gi 1207689358 423 SK 424
Cdd:cd17325 175 RP 176
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
59-412 |
5.45e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 42.14 E-value: 5.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 59 AAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGeYGTS 138
Cdd:cd17372 37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNY--------MWLIILRCLVGLGLGG-GPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 139 ATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILqnvlseadMISWGWRIPFVIGAIGALSVLWLRRTMdeseqfs 218
Cdd:cd17372 108 ASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLV--------MPRLGWRWLLAFSSVPSSLLLVFYRWT------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 219 kmdsesrenagtikalmkhPKAVLTVIGLTLGGTVAFY----TYTTYLQKFMVNSVGLDKGVVSWINFCAL--------- 285
Cdd:cd17372 173 -------------------PKTTLLLWVIWFGNAFAYYgvvlLTTELNNSHNVCGSKSDSDSGESPTEKQCrnsndvdyr 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 286 -LVFVVIQPIAGML-----SDKIGRRPLLMSfgILGTLLTVPLFLFMKQAHNPVMAFLLMtvGLIIVTGYTSINAIVKAE 359
Cdd:cd17372 234 dVFIATFAEFPGLLisaamIDRLGRKASMAS--MLFTCCIFLLLLLICQSPFILTVLLFG--GRACISAAFTVVYIYTPE 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1207689358 360 LFPTEIRALGVGLPYGLTvAIFGGTAEFIALWLKSiGHESLFFFYVAGCIAIS 412
Cdd:cd17372 310 VYPTAVRALGVGTGSSVG-RIGAILCPFIAQVLVH-GSQTIALLLFSVVCLVS 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
55-213 |
6.46e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 6.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 55 LLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTpsygtiGLLSPIILVLARLLQGISLGGE 134
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA------LLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207689358 135 YGTSATYLSEMASSGRRGFYSSFQYVTLVAGQLVAlgvqIILQNVLSEADMISWGWRIPFVIGAIGALSVLWLRRTMDE 213
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALG----PLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
187-338 |
1.24e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 41.03 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 187 SWGWRIPF-VIGAIGALSVLWLRRTMdeseqfSKMDSesrENAGTIK---ALMKHPkAVLTVIGLTLGGTVAFYTYTTYL 262
Cdd:PRK03545 159 YLGWRTTFlAIGGGALITLLLLIKLL------PLLPS---EHSGSLKslpLLFRRP-ALVSLYLLTVVVVTAHFTAYSYI 228
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207689358 263 QKFMVNSVGLDKGVVSWInfcaLLVFVVIQPIAGMLSDKIGRR--PLLMSFGILgtLLTVPLFLFMKQAHNPVMAFLL 338
Cdd:PRK03545 229 EPFVQQVAGLSENFATLL----LLLFGGAGIIGSVLFSRLGNRhpSGFLLIAIA--LLLVCLLLLLPAANSEWHLSVL 300
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
51-416 |
1.30e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.77 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 51 STSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGIS 130
Cdd:cd17333 29 NVADVSVIFSSQNAGYL---IGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSI--------YLFVVLMFLAGLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 131 LGGEYGTSATYLSEMaSSGRRGFYSSFQYVTLVAGQLVA-LGVQIILQNVLSeadmISWGWRIPFVIGAIGALsvLWLRR 209
Cdd:cd17333 98 AGILDTGANTFVGAL-FEESSATRLNVLHGFFGLGALIGpLIATSLLTSELS----WSWAYLIIGLIYLLLAI--LILLT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 210 TMDESEQFSKMDSESRENAGTIKALMKHPKAVLTVIGLTLGGtVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFV 289
Cdd:cd17333 171 LFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYV-GAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGIT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 290 VIQPIAGMLSDKIGRRPLLMsFGILGTLLTVPLFLFMKQAHnpVMAFLLMTVGLIIVTGYTSINAiVKAELFPteiRALG 369
Cdd:cd17333 250 IGRLLGGPISRRIKPHTLLV-LSGSGALLGLLILLLAPTLV--VGLVATALLGLFMAALFPTILS-LGISNLP---YAKG 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1207689358 370 VGLPYGLTVAIFGG-TAEFIALWLKSIGHESLFFFYVAGCIAISFLVY 416
Cdd:cd17333 323 KGTSVLLAAGSIGGaIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLA 370
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
59-372 |
2.01e-03 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 40.03 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 59 AAIFAVGFLmrpIGSLLMGRYAD-RYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGT 137
Cdd:cd17378 39 QSSFFVGCL---IGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY--------WVYAFLRFLTGFGRSGIGTC 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 138 SATYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVqiilqnvlseADMISWGWRIPFVIGAIGAL--SVLWLRrtmdese 215
Cdd:cd17378 108 ALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGI----------AYLNGSSWRVLYFWTSIPALiyCILVYL------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 216 qfskmdsesrenagTIKALMkhpkaVLTVIGLTLGgtVAFYTYTTYLQKFMVNsVGLDKGVVSWINFCALLvfvviqpIA 295
Cdd:cd17378 171 --------------FARRLL-----AVMVIGFGIG--MVYYGIPLAVGNLKFN-IYLSVALNALSELPAFV-------IT 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207689358 296 GMLSDKIGRRPLLMSFGILGTLLTVPLFlFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGL 372
Cdd:cd17378 222 AFLLDRFGRRPSLLGFTLLSGASCLLCF-VLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGM 297
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
62-193 |
2.03e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 40.14 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 62 FAVGFLMrpiGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPsygtigllSPIILVLARLLQGISLGGEYGTSATY 141
Cdd:cd17445 45 FILGFAS---GYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAA--------SPSLFMAMRFLLGAALAGVYLTLYLT 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1207689358 142 LSEMASSGRRGFYSSFQYVTLVAGQLVALGVQI------ILQNVLSEADMISWGWRIP 193
Cdd:cd17445 114 RLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALgcgswrVLQGTITAPLSLFLCYGCP 171
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
230-422 |
2.18e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.79 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 230 TIKALMKHPKAVLTVIGLTLGGTVAFYTYTTYL--QKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPL 307
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNvaLPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 308 LMsfgiLGTLLTVPLFLFMKQAHNPVMAFLL-----MTVGLIIVTGYTSInaivkAELFPTEIRALGVGLpYGLTVAIFG 382
Cdd:COG0477 82 LL----IGLLLFGLASLLCGLAPSPELLIAAralqgIGAGGLMPGALALI-----AELFPARERGRALGL-WGAAIGLGL 151
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1207689358 383 GTAEFIALWL-KSIGHESLFFFYVAGCIaISFLVYWRMGES 422
Cdd:COG0477 152 ALGPLLGGLLvAALGWRWIFLINAPLGL-LALVLRLRLPES 191
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
54-343 |
2.35e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.92 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 54 QLLNTAAIFAVGFL-MRPIGSLLMGRyadrygRRAALTLSItIMASGSFIIACTPSYGTIGLLspiilVLARLLQGISLG 132
Cdd:cd17327 42 QYNWGNTVFYVGYIiFELPGNLLLQR------FPPSKWLSV-FIVLWGLLTLLTAAVKNFGGL-----IALRFFLGLFES 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 133 GEYGTSATYLS------EMASsgRRGFYSSFQYVTLVAGQLVALGVQIILqNVLSEAdmiswGWRIPFVIGAI-----GA 201
Cdd:cd17327 110 GVFPGFILYLGmwykreEQAK--RIAFFYAAAGLGSIFGGLLAYGVFKIL-GVGGLA-----GWRWLFIIEGLitiiiGL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 202 LSVLWLRRTMDESEQFSKMDSE------SRENAGT---------IKALMKHPKAVLTVIGLTLGGTV--AFYTYTTYLQK 264
Cdd:cd17327 182 VIFFWLPDNPSKAWFLTEEEKElaverlRANQTGKgdqkfkwkqIKEAFKDPRTWLLFLFFFCSQITnnGISNFLPLILK 261
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207689358 265 FMvNSVGLDKGVVSWINFCALLVFVviqPIAGMLSDKIGRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGL 343
Cdd:cd17327 262 SL-GFYSLQTNLLSVPIGALGAVSL---LIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGS 336
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
71-402 |
2.69e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.67 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL--------WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGFYSSFQYVTL-VAGQLVALGVQIILQNVLSEadmiSWGWRIPFVIGAIGALSVLWLRRTMDESEQFSKMD----SESR 225
Cdd:TIGR00881 117 RGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSW----HWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEempnEEPD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 226 ENAGTIKALMKHPKAVLT-------VIGLTLGGTVAF---YTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIA 295
Cdd:TIGR00881 193 GDAEKKEEELTKKQIFLQyvllnkvLWYISLGYVFVYvvrTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 296 GMLSDKI--GRRPLLMSFGILGTLLTVPLFLFMKQAHNPVMAFLLMTVGLiIVTGYTSINAIVKAELFPTEIRALGVGLp 373
Cdd:TIGR00881 273 GWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGF-LVYGPQMLIGVIASELAPKKAAGTAAGF- 350
|
330 340
....*....|....*....|....*....
gi 1207689358 374 YGLTVAIFGGTAEFIALWLKSIGHESLFF 402
Cdd:TIGR00881 351 VGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
249-350 |
2.83e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.98 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 249 LGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDK----IGR-RPLLMSFGILGTLLTVPLF 323
Cdd:pfam13347 7 LAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRtrtrWGRrRPWLLLSAIILAVSFILLF 86
|
90 100
....*....|....*....|....*....
gi 1207689358 324 --LFMKQAHNPVMAFLLMTVGLIIVTGYT 350
Cdd:pfam13347 87 tpPELGRAPLFIWLLATYILLRIAYTFFE 115
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-202 |
3.46e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 16 NIFKGSVGNLIEWYDWYVYSAFAVYFSSQFFpeGDSTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITI 95
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTFLPTYLQTVL--GLSPATSSLYLLLISLGAL---VGALIAGLLSDRIGRKKTLVIGLIL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 96 MASGSFIiactpsYGTIGLLSPIILVLARLLQGISLGGEYGTSATYLSEMASSGRRGFYSSFQYvtlVAGQLVALGVQII 175
Cdd:cd17316 253 SGILALP------LFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSY---NLGRLGGGGAPPL 323
|
170 180
....*....|....*....|....*..
gi 1207689358 176 LQNVLSEADMISwgwrIPFVIGAIGAL 202
Cdd:cd17316 324 IALLLASTGGTG----VPALILALLAI 346
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
71-303 |
3.77e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 39.31 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSATYLSEMASSGR 150
Cdd:PRK10091 53 VGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSY--------LMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 rgfySSFQYVTLVAGQLVALGVQIILQNVLSEadmiSWGWRIPFVIGAIGALSVL-----WLRRTMDES-----EQFSkm 220
Cdd:PRK10091 125 ----VTAAVAGMVSGMTVANLLGIPLGTYLSQ----EFSWRYTFLLIAVFNIAVLasiyfWVPDIRDEAkgglrEQFH-- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 221 dsesrenagtikaLMKHPKAVLtVIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSD 300
Cdd:PRK10091 195 -------------FLRSPAPWL-IFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSG 260
|
...
gi 1207689358 301 KIG 303
Cdd:PRK10091 261 RYS 263
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
49-151 |
3.88e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.16 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 49 GDSTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGtigllspiILVLARLLQG 128
Cdd:cd17388 31 GDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLW--------WLYLGRIIAG 102
|
90 100
....*....|....*....|...
gi 1207689358 129 ISlGGEYGTSATYLSEMASSGRR 151
Cdd:cd17388 103 IT-GATGAVAAAYIADVTPPEQR 124
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
244-356 |
4.33e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 244 VIGLTLGGTVAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLmsfgILGTLLTVPLF 323
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVM----LAGLLLRALGF 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1207689358 324 LFMKQAHNPVmAFLLMTVGLIIVTG--YTSINAIV 356
Cdd:cd17329 80 ALLGFAHSPW-LFAIALVLTGFGGGlfEPASEAMI 113
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
30-130 |
4.61e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 39.12 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 30 DW----YVYsafAVYfSSQFFPEGDstsqllnTAAIFAVGFLMRPIGSLLMGRYADRYGRRAAltlsiTIMASGSFIIAC 105
Cdd:cd17487 19 DWlqgpYLY---ALY-ESYGFSEEQ-------IAILFVTGFGSSVVFGTFVGSLADKFGRKRA-----CLLFCVLYSLSC 82
|
90 100
....*....|....*....|....*..
gi 1207689358 106 tpsygtIGLLSP--IILVLARLLQGIS 130
Cdd:cd17487 83 ------LTKHSPnfGVLLLGRVLGGIS 103
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
71-419 |
6.07e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 6.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 71 IGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgTIGLLSPIILVLARLLQGislggeygtSATYLSEMASSGR 150
Cdd:cd17331 50 VGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSV-PMLFLSRLPSVFMHAMQA---------AQMVVTDLTDPGE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 151 RGfySSFQYVTLvagqlvALGVQIILQNVLSEADMISWGWRIPFVIGAIG-----ALSVLWLR---RTMDESEQFSKMDS 222
Cdd:cd17331 120 RA--AALGRLGL------SYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGsllsiVLVILLIPsntKSKREKEAKESASP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 223 ESRENAGTIKALMKHPKAVLTVIGLTLGGTvAFYTYTTYLQKFMVNSVGLDKGVVSWINFCALLVFVVIQPI-AGMLSDK 301
Cdd:cd17331 192 PSVFNLKEILRLLRLPGVAFLLLVKLLSGL-PIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLlVGPLTKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 302 IGRRPLLmsfgILGTLLTVPLFLFMKQAhNPVMAFLLMTVGLII--VTGYTSINAIVkAELFPTEIRALGVGLPYGLTVA 379
Cdd:cd17331 271 FGERSLL----KLSVALLAIGYLLLAFV-TTVWQLLVLLLPLVIggSVLYTVITSLL-TKAVPPEDTGTALGLSHALFSL 344
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1207689358 380 IFGGTAEFIALWLKSIGHESlfFFYVAGCIAISFLVYWRM 419
Cdd:cd17331 345 VRTVSPTIGGALLQAYGFPS--FGLLGAAINGLLTVYLLL 382
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
244-418 |
6.61e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 244 VIGLTLGGTVAFYTYTTYLQKFMVNSVGlDKGVVSWINFCALLVFVVIQPIAGMLSDKIGRRPLLmsfgILGTLLTVPLF 323
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFF----IGGNLLGVVGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 324 LFMKQAHNPVMAFLLMTVgLIIVTGYTSINAIVKAELFPTEIRALGVGLPYgLTVAIFGGTAEFIALWLKSIGHES---L 400
Cdd:cd06179 77 IVAGTAKSVNMLIGGQAL-IGIGAGTQGLGAAVASELVPNKYRGLVQGVVN-LVASPGSALGPLIAGALVEANAAGwrwI 154
|
170 180
....*....|....*....|
gi 1207689358 401 FFFYVA--GCIAISFLVYWR 418
Cdd:cd06179 155 FYINAIfnALALILLFFFYH 174
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
60-383 |
7.00e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.55 E-value: 7.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 60 AIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYgtigllspIILVLARLLQGISLGGEYGTSA 139
Cdd:cd17446 40 SIYMAGVL---VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSF--------PIYCVFRFLTGMALSGIVLNSV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 140 TYLSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQNvlseadmisWGW-----RIPFVigaIGALSVLWLrrtmdes 214
Cdd:cd17446 109 SLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRD---------WRWlqlavSLPFF---IFFLYSWWF------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 215 eqfskmdsesrenagtikalmkhPKAVLTVIGLTLGGTVAFYTYTTYLQKFMVnSVGLDKGVVSWINFCALLVFVVIqpi 294
Cdd:cd17446 170 -----------------------PRITFCLSLVWFSTSFAYYGLAMDLQKFGV-SIYLIQIIFGAVDIPAKFISTLT--- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 295 agmlSDKIGRRPLLMSFGILGTL-----LTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSinaivkaELFPTEIRALG 369
Cdd:cd17446 223 ----MSYLGRRPTQAAALILAGImilanIFVPQDLQTVRTALAVFGKGCLAASFNCVYLYTG-------ELYPTVIRQTG 291
|
330
....*....|....
gi 1207689358 370 VGLpyGLTVAIFGG 383
Cdd:cd17446 292 MGL--GSTMARLGG 303
|
|
| MFS_SLC22A31 |
cd17443 |
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ... |
62-404 |
8.11e-03 |
|
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341001 [Multi-domain] Cd Length: 343 Bit Score: 38.22 E-value: 8.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 62 FAVGFLMrpiGSLLMGRYADRYGRRAALTLSItIMASGSFIIACTPSygtigllSPIILVLARLLQGISLGGEYGTSATY 141
Cdd:cd17443 45 YLLGWLL---GYIILGAGCDRLGRRAAFVLSL-VLATLLGVSVALSA-------SPPTFLVLRLLQGGTLAGVFLSLYIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 142 LSEMASSGRRGFYSSFQYVTLVAGQLVALGVQIILQnvlseadmiswGWRI--PFVIGAIGALSVLWLRRTMDeseqfsk 219
Cdd:cd17443 114 RLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCR-----------DWRVlqGVGTLPLLLLLLYWCFPSRN------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 220 mdsesrenagtiKALMKHPKAVLTVIGLTLGGTVAFYTYTTYLQKFMvnSVGLdkGVVSWINFCallvfvviqpiagMLS 299
Cdd:cd17443 176 ------------GLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFL--QAGL--EALACIFLC-------------LTV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 300 DKIGRRPLLMSFGILgTLLTVPLFLFMKQAHNPVMAFLLMTVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYGltvA 379
Cdd:cd17443 227 DRCGRRGVLLLGTIV-TGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAGLGLIMG---A 302
|
330 340
....*....|....*....|....*
gi 1207689358 380 IFGGTAefiALWLKSIGHESLFFFY 404
Cdd:cd17443 303 GFLGRA---AGPLMELQNKQGYFLH 324
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
58-205 |
9.03e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.33 E-value: 9.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207689358 58 TAAIFAVGFLmrpIGSLLMGRYADRYGRRAALTLSITIMASGSFIIACTPSYGTIgllspIILvlaRLLQGISLGGEYGT 137
Cdd:cd17323 39 GVSLFVLGFG---LGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAML-----IIL---RFLQGFFGSSPLAI 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207689358 138 SATYLSEMASSGRRGFYSSFQYVTLVAGQLVAlgvqIILQNVLSEadmiSWGWRIPFVIGAIGALSVL 205
Cdd:cd17323 108 GAGTIADLFTPEERGKAMGVYSLGPLLGPALG----PIIGGFITQ----SLGWRWIFWFLAIISGFCL 167
|
|
| |
