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Conserved domains on  [gi|1207696752|ref|WP_088055315|]
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iron ABC transporter permease [Bacillus toyonensis]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 22-321 1.58e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.03  E-value: 1.58e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  22 SAMKGSLEVGIVELVQGIFTGGNEDVE--VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGISSGASFMT 99
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTAdlIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 100 LVIITLFPQF-FFWTPVFAFLGGALACYLVYSFSWK-SGLSPFRIILIGIAINAMFTGLnesfVTICGYF-----IKSIK 172
Cdd:COG0609    81 VLAIVLGGGLsALGLPLAAFLGALLAALLVYLLARRgGGLSPLRLVLAGVAVSALFSAL----TSLLLLLadpeqLRSIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 173 QTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGVIAF 252
Cdd:COG0609   157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207696752 253 VGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRKS 321
Cdd:COG0609   237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 22-321 1.58e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.03  E-value: 1.58e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  22 SAMKGSLEVGIVELVQGIFTGGNEDVE--VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGISSGASFMT 99
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTAdlIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 100 LVIITLFPQF-FFWTPVFAFLGGALACYLVYSFSWK-SGLSPFRIILIGIAINAMFTGLnesfVTICGYF-----IKSIK 172
Cdd:COG0609    81 VLAIVLGGGLsALGLPLAAFLGALLAALLVYLLARRgGGLSPLRLVLAGVAVSALFSAL----TSLLLLLadpeqLRSIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 173 QTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGVIAF 252
Cdd:COG0609   157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207696752 253 VGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRKS 321
Cdd:COG0609   237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 14-320 3.27e-76

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 236.27  E-value: 3.27e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  14 LLIVMTSLSAMKGSLEVGIVELVQGIFTGGNEDV-EVIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGIS 92
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAaLIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  93 SGASFM-TLVIITLFPQFFFWTPVFAFLGGALACYLVYSFS-WKSGLSPFRIILIGIAINAMFTGLNESFVTICGY-FIK 169
Cdd:pfam01032  81 SGAALGaVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSrGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPeALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 170 SIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGV 249
Cdd:pfam01032 161 SILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207696752 250 IAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRK 320
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
6-321 6.30e-68

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 224.33  E-value: 6.30e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   6 WSFLIVTALLIVMTSLSAMKGSLEVGIVelvqgiFTGGNEDVEVIkDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLAD 85
Cdd:PRK10577  356 AWLLALGLLLLLALVVALSFGRDAHGWN------WLSGQLLDALL-PLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLAS 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  86 AGVIGISSGASFMTLVIITLFPQFFFWT-PVFAFLGGALACYLVYSFSWKSGLSPFRIILIGIAINAMFTGLNeSFVTIC 164
Cdd:PRK10577  429 PEVLGISSGAGLGVVLALFLVPGAGFGWlLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFTALI-QLLLAS 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 165 GYFIKSIKQTTTSNIT-MKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVS 243
Cdd:PRK10577  508 GDPRAAQLLTWLSGSTyGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAA 587

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207696752 244 TAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRKS 321
Cdd:PRK10577  588 TATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRS 665
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 58-318 7.06e-45

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 153.87  E-value: 7.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  58 IIIALFTGAALAVSGVLFQAVMKNPLADAGVIGISSGASFMTLVIITLFPQFF-FWTPVFAFLGGALACYLVYSFSWKSG 136
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSnYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 137 LSPFRIILIGIAINAMFTGLNESFVTICGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDK 216
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 217 TAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVp 296
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                         250       260
                  ....*....|....*....|..
gi 1207696752 297 PNEIPAATIMAVIGGPFLIFLL 318
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 22-321 1.58e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.03  E-value: 1.58e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  22 SAMKGSLEVGIVELVQGIFTGGNEDVE--VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGISSGASFMT 99
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTAdlIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 100 LVIITLFPQF-FFWTPVFAFLGGALACYLVYSFSWK-SGLSPFRIILIGIAINAMFTGLnesfVTICGYF-----IKSIK 172
Cdd:COG0609    81 VLAIVLGGGLsALGLPLAAFLGALLAALLVYLLARRgGGLSPLRLVLAGVAVSALFSAL----TSLLLLLadpeqLRSIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 173 QTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGVIAF 252
Cdd:COG0609   157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207696752 253 VGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRKS 321
Cdd:COG0609   237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 14-320 3.27e-76

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 236.27  E-value: 3.27e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  14 LLIVMTSLSAMKGSLEVGIVELVQGIFTGGNEDV-EVIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGIS 92
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAaLIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  93 SGASFM-TLVIITLFPQFFFWTPVFAFLGGALACYLVYSFS-WKSGLSPFRIILIGIAINAMFTGLNESFVTICGY-FIK 169
Cdd:pfam01032  81 SGAALGaVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSrGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPeALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 170 SIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGV 249
Cdd:pfam01032 161 SILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207696752 250 IAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRK 320
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 9-318 2.84e-71

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 224.61  E-value: 2.84e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   9 LIVTALLIVMTSLSAMKGSLEVGIVELVQGIFTGGNEDVE-VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAG 87
Cdd:COG4779    27 LVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGASfVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  88 VIGISSGASFMTLVIITLFPQFFFWTPVFAFLGGALACYLVYSFSWKSGLSPFRIILIGIAINAMFTGLNesfvticGYF 167
Cdd:COG4779   107 IIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLAWRGGVSGYRLILVGIGVSAMLTAVN-------SYL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 168 IKSIKQT--------TTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLL 239
Cdd:COG4779   180 LTRADLEdaqsaavwLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVAL 259

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207696752 240 AAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPfSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLL 318
Cdd:COG4779   260 AAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLL 337
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
6-321 6.30e-68

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 224.33  E-value: 6.30e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   6 WSFLIVTALLIVMTSLSAMKGSLEVGIVelvqgiFTGGNEDVEVIkDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLAD 85
Cdd:PRK10577  356 AWLLALGLLLLLALVVALSFGRDAHGWN------WLSGQLLDALL-PLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLAS 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  86 AGVIGISSGASFMTLVIITLFPQFFFWT-PVFAFLGGALACYLVYSFSWKSGLSPFRIILIGIAINAMFTGLNeSFVTIC 164
Cdd:PRK10577  429 PEVLGISSGAGLGVVLALFLVPGAGFGWlLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFTALI-QLLLAS 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 165 GYFIKSIKQTTTSNIT-MKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVS 243
Cdd:PRK10577  508 GDPRAAQLLTWLSGSTyGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAA 587

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207696752 244 TAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRKS 321
Cdd:PRK10577  588 TATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRS 665
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
4-320 1.14e-59

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 202.38  E-value: 1.14e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   4 KTWSFLIVTALLIVMTSLSAMKGSLEVGIVELVQGIFTGGNEDVE--VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKN 81
Cdd:PRK10577   10 ARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEqlLLHYSRLPRLAIALLVGAALGLAGALLQQVLRN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  82 PLADAGVIGISSGASF-MTLVIITLFPQFFFWTPVFAFLGGALACYLVYSFSWKSGLSPFRIILIGIAINAMFTGLNESF 160
Cdd:PRK10577   90 PLASPTTLGVAAGAQLaLVLATLFAPALLALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 161 VTICGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLA 240
Cdd:PRK10577  170 LLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLS 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 241 AVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPP--NEIPAATIMAVIGGPFLIFLL 318
Cdd:PRK10577  250 AAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVggELLPTGAVTALIGAPLLLWLL 329


                  ..
gi 1207696752 319 RK 320
Cdd:PRK10577  330 PR 331
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
3-318 1.63e-57

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 188.33  E-value: 1.63e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   3 KKTWSFLIVTALLIVMTSLSAMKGSLEVGIVELVQGiFTGGNEDVEVIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNP 82
Cdd:PRK09777    1 MKIALVIFITLALAGCALLSLRMGVIPLPWRALLTD-WQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  83 LADAGVIGISSGASFMTLVIITLFPQF-FFWTPVFAFLGGALACYLVYSFSWKSglSPFRIILIGIAINAMFTGLNESFV 161
Cdd:PRK09777   80 LASPDILGVNHAASLASVGALLLFPSLpVMWLPLLAFIGGMAGLILLKMLAGTH--QPMKLALTGVALSALWASLTDYLM 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 162 TICGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAA 241
Cdd:PRK09777  158 LSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTA 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207696752 242 VSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLL 318
Cdd:PRK09777  238 TGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLL 314
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
6-320 6.37e-49

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 166.02  E-value: 6.37e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   6 WSFLIVTALLIVMTSLSAMKgSLEVGIVELVQGIFTG-GNEDVEVI-KDLRFPRIIIALFTGAALAVSGVLFQAVMKNPL 83
Cdd:PRK11228    2 WGLPVAALIGLFWLSLFCYS-AIPISAADALNALLPGhTPTLPEALvQNLRLPRSLVAVLIGASLALAGALLQTLTHNPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  84 ADAGVIGISSGASFMTLVIITLFPQFF--FWTPVFAFLGGALACYLVYSFS--WKSGLSPFRIILIGIAINAMFTGLNES 159
Cdd:PRK11228   81 ASPSLLGINSGAALAMALTSALSPTPFagYSLAFIAACGGGLSWLLVMTAGggWRHTHDRNRLILAGIALSALCMALTRI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 160 FVTICGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLL 239
Cdd:PRK11228  161 TLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 240 AAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLR 319
Cdd:PRK11228  241 VGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLAR 320


                  .
gi 1207696752 320 K 320
Cdd:PRK11228  321 R 321
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 7-325 9.33e-46

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 158.09  E-value: 9.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   7 SFLIVTALLIVMTSLSAMKGSLEVGIVELVqgiftggNEDVE-VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLAD 85
Cdd:COG4139    14 WLLLLLLLLLLLFVLSLCAGEVWIPPTQWL-------SEAWQlFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  86 AGVIGISSGASFMTLVIITLFPQFF-FWTPVF-AFLGGALACYLVYSFSWKsGLSPFRIILIGIAINAMFTglneSFVTI 163
Cdd:COG4139    87 PGLLGISNGAGVGLVLVVLLGGGLLpPWLLSLaAIAGALLVTLLLLAFARR-RLSNARLLLIGVALGIICS----AIMTW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 164 CGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWC----NLLSLQDKTAKNLGLHVTRVRLIISAIAVLL 239
Cdd:COG4139   162 AVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALLPVLLWLCLQgkplNLLLLGENQARQLGLSVHRWRNLLVLATGLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 240 AAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLR 319
Cdd:COG4139   242 VGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLL 321


                  ....*.
gi 1207696752 320 KSDKVH 325
Cdd:COG4139   322 RRRKIR 327
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
13-320 1.19e-45

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 157.95  E-value: 1.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  13 ALLIVMTSLSAMKGSLEVGIVELVQGIF-TGGNEDVEVIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGI 91
Cdd:PRK10441   18 LLLIIATALSLLIGAKSLPASVVLEALSgTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  92 SSGASFMTLVIITLF----PQFFFWtpvFAFLGGALACYLVYSFSWKSG--LSPFRIILIGIAINAMFTGLNESFVTICG 165
Cdd:PRK10441   98 NAGASFAIVLGAALFgyssAQEQLA---MAFAGALVASLIVAFTGSQGGgqLSPVRLTLAGVALAAVLEGLTSGIALLNP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 166 YFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVSTA 245
Cdd:PRK10441  175 DVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATA 254

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207696752 246 IAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVpPNEIPAATIMAVIGGPFLIFLLRK 320
Cdd:PRK10441  255 VVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRR 328
btuC PRK09535
cobalamin ABC transporter permease BtuC;
49-320 1.53e-45

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 158.38  E-value: 1.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  49 VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGISSGASFMTLVIITLFPQFFFWTPVFAFLGGALACYLV 128
Cdd:PRK09535   90 IVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFGLQAAAFAGALVAAFGV 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 129 YSFSWKSGLSPFRIILI-GIAINAmFTGLNESFVTI-CGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGA 206
Cdd:PRK09535  170 YAIATENGRTPVATLLLaGVAVQT-FLGAVISYLLLhSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYAR 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 207 WCNLLSLQDKTAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILT 286
Cdd:PRK09535  249 DLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVA 328

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1207696752 287 ADTIGRLivPPNEIPAATIMAVIGGPFLIFLLRK 320
Cdd:PRK09535  329 TDTVARS--GPAEVPVGIVTAALGAPFFLYLLRT 360
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 58-318 7.06e-45

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 153.87  E-value: 7.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  58 IIIALFTGAALAVSGVLFQAVMKNPLADAGVIGISSGASFMTLVIITLFPQFF-FWTPVFAFLGGALACYLVYSFSWKSG 136
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSnYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 137 LSPFRIILIGIAINAMFTGLNESFVTICGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDK 216
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 217 TAKNLGLHVTRVRLIISAIAVLLAAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLILTADTIGRLIVp 296
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                         250       260
                  ....*....|....*....|..
gi 1207696752 297 PNEIPAATIMAVIGGPFLIFLL 318
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYLL 261
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
9-318 1.34e-44

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 155.25  E-value: 1.34e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752   9 LIVTALLIVMTSLSAMKGSLEVGIVEL-----VQGIFTGGNEDVE-VIKDLRFPRIIIALFTGAALAVSGVLFQAVMKNP 82
Cdd:PRK10440    8 LLITCLLLLAACVAAGLWGLRSGAVTLetsqvFAALMGDAPRSMTmVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  83 LADAGVIGISSGASFMTLVIITLFPQFFFWTPVFAFLGGALACYLVYSFSWKSGLSPFRIILIGIAINAMFTGLNESFVt 162
Cdd:PRK10440   88 LGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLL- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 163 icgyfIKSIKQTTTS-------NITMKTWGDVEIMVTYGTIGLILALFVGAWCNLLSLQDKTAKNLGLHVTRVRLIISAI 235
Cdd:PRK10440  167 -----LKASLETALTaglwnagSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 236 AVLLAAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPfSALAGALLILTADTIGRLIVPPNEIPAATIMAVIGGPFLI 315
Cdd:PRK10440  242 AVVLTAAATALAGPISFIALVAPHIARRLSGTARWGLTQ-AALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLI 320


                  ...
gi 1207696752 316 FLL 318
Cdd:PRK10440  321 VLL 323
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 52-325 2.90e-43

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 151.65  E-value: 2.90e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752  52 DLRFPRIIIALFTGAALAVSGVLFQAVMKNPLADAGVIGISSGASFMTLVIITLFPQFF-FWTPVFAFLGGALACYLVY- 129
Cdd:PRK03784   56 QLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLpPWALSLCAIAGALLITLILl 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 130 SFSWKSGLSPFRIILIGIAINAMFTGLnesfVTICGYFIKSIKQTTTSNITMKTWGDVEIMVTYGTIGLILALFVGAWC- 208
Cdd:PRK03784  136 RFARRHRLSTSRLLLAGVALGIICSAL----MTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLPVLIWLCCQg 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207696752 209 ---NLLSLQDKTAKNLGLHVTRVR-LIISAIAvLLAAVSTAIAGVIAFVGLLVPHISRQLVGSDHKVLIPFSALAGALLI 284
Cdd:PRK03784  212 rplNMLALGEISARQLGLPLWFWRnLLVLATG-WLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLL 290

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1207696752 285 LTADTIGRLIVPPNEIPAATIMAVIGGPFLIFLLRKSDKVH 325
Cdd:PRK03784  291 LLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSHRAR 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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