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Conserved domains on  [gi|1209279056|ref|WP_088326585|]
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MULTISPECIES: sigma-70 family RNA polymerase sigma factor [Bacillus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RpoD super family cl33954
DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA ...
40-299 7.30e-46

DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) is part of the Pathway/BioSystem: RNA polymerase


The actual alignment was detected with superfamily member COG0568:

Pssm-ID: 440334 [Multi-domain]  Cd Length: 268  Bit Score: 156.37  E-value: 7.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  40 IKEIGNYQVLSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKHpdIEFDDLVQEGNEGMLRAMEDFNPALG 119
Cdd:COG0568     3 LREIGRVPLLTAEEEVELARRIQAGDEEAKRKLVEANLRLVVSIAKKYQGRG--LPLLDLIQEGNLGLMKAVEKFDPERG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 120 YCFSTYAFWWI----------QKRMLgiickkrsgpfKIPNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEI 189
Cdd:COG0568    81 FRFSTYATWWIrqaitraiadQWRTI-----------RLPVHMAETLNKLRRAKRQLLQELGREPTPEEIAEELGVPEEK 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 190 VIRHNVYYKRatTMTLDIdTINEDigiSNSSHDD---KSAIPSINEMVIEDLNYEI---WLifdEVLNPKQKMVLNLCFG 263
Cdd:COG0568   150 VREMLRLARE--PVSLDA-PVGDD---EDSELGDlleDEEAPSPEEALEEELLREElreAL---DTLTEREREILRLRFG 220
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1209279056 264 LLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:COG0568   221 LDDGEPHTLEEIGKEFGVSRERVRQIEAKALRKLRH 256
 
Name Accession Description Interval E-value
RpoD COG0568
DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA ...
40-299 7.30e-46

DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 440334 [Multi-domain]  Cd Length: 268  Bit Score: 156.37  E-value: 7.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  40 IKEIGNYQVLSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKHpdIEFDDLVQEGNEGMLRAMEDFNPALG 119
Cdd:COG0568     3 LREIGRVPLLTAEEEVELARRIQAGDEEAKRKLVEANLRLVVSIAKKYQGRG--LPLLDLIQEGNLGLMKAVEKFDPERG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 120 YCFSTYAFWWI----------QKRMLgiickkrsgpfKIPNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEI 189
Cdd:COG0568    81 FRFSTYATWWIrqaitraiadQWRTI-----------RLPVHMAETLNKLRRAKRQLLQELGREPTPEEIAEELGVPEEK 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 190 VIRHNVYYKRatTMTLDIdTINEDigiSNSSHDD---KSAIPSINEMVIEDLNYEI---WLifdEVLNPKQKMVLNLCFG 263
Cdd:COG0568   150 VREMLRLARE--PVSLDA-PVGDD---EDSELGDlleDEEAPSPEEALEEELLREElreAL---DTLTEREREILRLRFG 220
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1209279056 264 LLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:COG0568   221 LDDGEPHTLEEIGKEFGVSRERVRQIEAKALRKLRH 256
PRK07598 PRK07598
RNA polymerase sigma factor SigC; Validated
69-310 1.55e-29

RNA polymerase sigma factor SigC; Validated


Pssm-ID: 236067 [Multi-domain]  Cd Length: 415  Bit Score: 116.51  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  69 RDYLFHVNVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIICKKrSGPFKI 148
Cdd:PRK07598  177 KEHMIKANLRLVVSVAKKYQNR--GLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQGITRAIATQ-SRTIRL 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 149 PNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIVIRHNVYYKRATTMTL----DIDTINEDIgisnSSHDDK 224
Cdd:PRK07598  254 PVHITEKLNKIKKAQRKISQEKGRTPTIEDIAQELEMTPTQVREVLLRVPRSVSLETkvgkDKDTELGDL----LETDDI 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 225 SaiPSiNEMVIEDLNYEIWLIFDEvLNPKQKMVLNLCFGLLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKKCDYKD 304
Cdd:PRK07598  330 S--PE-EMLMRESLQRDLQHLLAD-LTSRERDVIRMRFGLADGHTYSLAEIGRALDLSRERVRQIESKALQKLRQPKRRN 405

                  ....*.
gi 1209279056 305 EIFNLL 310
Cdd:PRK07598  406 RIRDYL 411
FliA_WhiG TIGR02479
RNA polymerase sigma factor, FliA/WhiG family; Most members of this family are the flagellar ...
79-300 4.66e-18

RNA polymerase sigma factor, FliA/WhiG family; Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.


Pssm-ID: 274153 [Multi-domain]  Cd Length: 224  Bit Score: 81.55  E-value: 4.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  79 LVLSIARKYKNKHPD-IEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIICKKRSGPFKIPNYVNQFNL 157
Cdd:TIGR02479   8 LVKRIAGRLSVGLPSsVELDDLIQAGMFGLLDAIERYDPSRGAKFETYAVQRIRGAMLDELRRLDWVPRSLRQKARKLER 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 158 KYVELEdkylQMYNRPPSVEEVVKELDVTSEIVirHNVYYKRATTMTLDIDTINEDIGISNSSHD---DKSAIPSINEMV 234
Cdd:TIGR02479  88 AIRELE----ARLGREPTEEEIAEELGMDLKEY--RQALNEINALSLVSLDELLESGDDGGSLIDrieDDKSEDPEEELE 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 235 IEDLNYEIWLIFDEvLNPKQKMVLNLcfglldgkVYLH----KEIAKALMITTERVSQIKEEAIKKLKKC 300
Cdd:TIGR02479 162 REELREALAEAIES-LSEREQLVLSL--------YYYEelnlKEIGEVLGLTESRVSQIHSQALKKLRAK 222
Sigma70_r2 pfam04542
Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. ...
72-135 5.60e-14

Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant. The core binding helix, interacts with the clamp domain of the largest polymerase subunit, beta prime. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation.


Pssm-ID: 427998 [Multi-domain]  Cd Length: 71  Bit Score: 66.07  E-value: 5.60e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1209279056  72 LFHVNVGLVLSIARKYKNKHPDIEfdDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRML 135
Cdd:pfam04542   1 LVERYLPLVYSLARRYLGDGADAE--DLVQEGFLGLWRAIERFDPERGVSFSTWLYTIIRNAII 62
Sigma70_r4 cd06171
Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in ...
248-298 1.12e-05

Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or plastid core RNA polymerase to specific promoter elements located upstream of transcription initiation points. The SR4 of Ec sigma70 and other essential primary SFs contact promoter sequences located 35 base-pairs upstream of the initiation point, recognizing a 6-base-pair -35 consensus TTGACA. Sigma70 related SFs also include SFs which are dispensable for bacterial cell growth for example Ec sigmaS, SFs which activate regulons in response to a specific signal for example heat-shock Ec sigmaH, and a group of SFs which includes the extracytoplasmic function (ECF) SFs and is typified by Ec sigmaE which contains SR2 and -4 only. ECF SFs direct the transcription of genes that regulate various responses including periplasmic stress and pathogenesis. Ec sigmaE SR4 also contacts the -35 element, but recognizes a different consensus (a 7-base-pair GGAACTT). Plant SFs recognize sigma70 type promoters and direct transcription of the major plastid RNA polymerase, plastid-encoded RNA polymerase (PEP).


Pssm-ID: 100119 [Multi-domain]  Cd Length: 55  Bit Score: 42.09  E-value: 1.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1209279056 248 EVLNPKQKMVLNLCFGllDGKVYlhKEIAKALMITTERVSQIKEEAIKKLK 298
Cdd:cd06171     9 DKLPEREREVILLRFG--EGLSY--EEIAEILGISRSTVRQRLHRALKKLR 55
 
Name Accession Description Interval E-value
RpoD COG0568
DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA ...
40-299 7.30e-46

DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 440334 [Multi-domain]  Cd Length: 268  Bit Score: 156.37  E-value: 7.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  40 IKEIGNYQVLSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKHpdIEFDDLVQEGNEGMLRAMEDFNPALG 119
Cdd:COG0568     3 LREIGRVPLLTAEEEVELARRIQAGDEEAKRKLVEANLRLVVSIAKKYQGRG--LPLLDLIQEGNLGLMKAVEKFDPERG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 120 YCFSTYAFWWI----------QKRMLgiickkrsgpfKIPNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEI 189
Cdd:COG0568    81 FRFSTYATWWIrqaitraiadQWRTI-----------RLPVHMAETLNKLRRAKRQLLQELGREPTPEEIAEELGVPEEK 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 190 VIRHNVYYKRatTMTLDIdTINEDigiSNSSHDD---KSAIPSINEMVIEDLNYEI---WLifdEVLNPKQKMVLNLCFG 263
Cdd:COG0568   150 VREMLRLARE--PVSLDA-PVGDD---EDSELGDlleDEEAPSPEEALEEELLREElreAL---DTLTEREREILRLRFG 220
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1209279056 264 LLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:COG0568   221 LDDGEPHTLEEIGKEFGVSRERVRQIEAKALRKLRH 256
FliA COG1191
DNA-directed RNA polymerase specialized sigma subunit [Transcription]; DNA-directed RNA ...
53-299 3.74e-30

DNA-directed RNA polymerase specialized sigma subunit [Transcription]; DNA-directed RNA polymerase specialized sigma subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 440804 [Multi-domain]  Cd Length: 236  Bit Score: 114.15  E-value: 3.74e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  53 ESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKHPDiEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQK 132
Cdd:COG1191     1 DLEELLRRYQEGDEEAREELIEEYLPLVKKIASRLAGRLPA-ELDDLIQVGLIGLIEAIDRFDPSKGVSFETYAVPRIRG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 133 RMLGIICKKRsgpfKIPNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIVIRHNVYYKRATTMTLDiDTINE 212
Cdd:COG1191    80 AILDYLRDED----WVPRSVRELARKIEEAIEELEQELGREPTDEEIAEELGISLEEVQEALEAANAYQLLSLD-EPLED 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 213 DIGISNSSHDDKSAIPSINEMVIEDLNYEIwlifdEVLNPKQKMVLNLcfglldgkVYLH----KEIAKALMITTERVSQ 288
Cdd:COG1191   155 GDDLLDLLESGDPEEELEHEELREALAEAI-----EQLPERERLVLSL--------YYFEeltlKEIAEVLGVSESRVSR 221
                         250
                  ....*....|.
gi 1209279056 289 IKEEAIKKLKK 299
Cdd:COG1191   222 LHKKALARLRE 232
PRK07598 PRK07598
RNA polymerase sigma factor SigC; Validated
69-310 1.55e-29

RNA polymerase sigma factor SigC; Validated


Pssm-ID: 236067 [Multi-domain]  Cd Length: 415  Bit Score: 116.51  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  69 RDYLFHVNVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIICKKrSGPFKI 148
Cdd:PRK07598  177 KEHMIKANLRLVVSVAKKYQNR--GLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQGITRAIATQ-SRTIRL 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 149 PNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIVIRHNVYYKRATTMTL----DIDTINEDIgisnSSHDDK 224
Cdd:PRK07598  254 PVHITEKLNKIKKAQRKISQEKGRTPTIEDIAQELEMTPTQVREVLLRVPRSVSLETkvgkDKDTELGDL----LETDDI 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 225 SaiPSiNEMVIEDLNYEIWLIFDEvLNPKQKMVLNLCFGLLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKKCDYKD 304
Cdd:PRK07598  330 S--PE-EMLMRESLQRDLQHLLAD-LTSRERDVIRMRFGLADGHTYSLAEIGRALDLSRERVRQIESKALQKLRQPKRRN 405

                  ....*.
gi 1209279056 305 EIFNLL 310
Cdd:PRK07598  406 RIRDYL 411
PRK09210 PRK09210
RNA polymerase sigma factor RpoD; Validated
40-298 1.48e-28

RNA polymerase sigma factor RpoD; Validated


Pssm-ID: 236413 [Multi-domain]  Cd Length: 367  Bit Score: 113.16  E-value: 1.48e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  40 IKEIGNYQVLSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFNPALG 119
Cdd:PRK09210  102 LKEIGRVPLLTAEEEIELAKRIEEGDEEAKQRLAEANLRLVVSIAKRYVGR--GMLFLDLIQEGNMGLMKAVEKFDYRKG 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 120 YCFSTYAFWWI-QKRMLGIICKKRSgpFKIP-NYVNQFNlKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIViRhnvyy 197
Cdd:PRK09210  180 FKFSTYATWWIrQAITRAIADQART--IRIPvHMVETIN-KLIRVQRQLLQELGREPTPEEIAEEMDMPPEKV-R----- 250
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 198 krattmtlDIDTINED-------IGISNSSH------DDKSAIPS---INEMVIEDLnyeiwlifDEVLN---PKQKMVL 258
Cdd:PRK09210  251 --------EILKIAQEpvsletpIGEEDDSHlgdfieDQDATSPAdhaAYELLKEQL--------EDVLDtltDREENVL 314
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1209279056 259 NLCFGLLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLK 298
Cdd:PRK09210  315 RLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLR 354
PRK07405 PRK07405
RNA polymerase sigma factor SigD; Validated
76-299 1.52e-27

RNA polymerase sigma factor SigD; Validated


Pssm-ID: 180963 [Multi-domain]  Cd Length: 317  Bit Score: 109.46  E-value: 1.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  76 NVGLVLSIARKYKNKHPDIEfdDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIICKKrSGPFKIPNYVNQF 155
Cdd:PRK07405   90 NLRLVVSVAKKYLKRNVDLL--DLIQEGTIGMQRGVEKFDPTKGYRFSTYAYWWIRQAITRAIAEK-SRTIRLPIHITEK 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 156 NLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIVirhNVYYKRA-TTMTLDI------DT----INEDIGISNSSHDDK 224
Cdd:PRK07405  167 LNKIKKAQRQLSQQLGRAATIGELAEELELTPKQV---REYLERArQPLSLDLrvgdnqDTelgeLLEDTGASPEDFATQ 243
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1209279056 225 SAIPSINEMVIEDlnyeiwlifdevLNPKQKMVLNLCFGLLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:PRK07405  244 SSLQLDLERLMED------------LTPQQKEVIALRFGLEDGQPLTLAKIGERLNISRERVRQIEREALSKLRK 306
PRK05949 PRK05949
RNA polymerase sigma factor; Validated
76-299 1.33e-25

RNA polymerase sigma factor; Validated


Pssm-ID: 180321 [Multi-domain]  Cd Length: 327  Bit Score: 104.15  E-value: 1.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  76 NVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIICKKRSG---PFKIPNYV 152
Cdd:PRK05949  100 NLRLVVAIAKKYQKR--NMEFLDLIQEGTLGLERGVEKFDPTRGYKFSTYAYWWIRQAITRAIAQQARTirlPIHITEKL 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 153 NQFNLKYVELEdkylQMYNRPPSVEEVVKELDVTSEiVIRHNVYYKRaTTMTLDIDT-INEDIGISNSSHDDKSAiPSI- 230
Cdd:PRK05949  178 NKIKKTQRELS----QKLGRSATPAEIAKELELEPS-QIREYLSMAR-QPISLDVRVgDNQDTELSELLEDEGPS-PDQy 250
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1209279056 231 --NEMVIEDLNYeiWLifdEVLNPKQKMVLNLCFGLLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:PRK05949  251 itQELLRQDLNN--LL---AELTPQQREVLTLRFGLEDGKELSLAKVGERLNLSRERVRQLEHQALAHLRR 316
PRK05657 PRK05657
RNA polymerase sigma factor RpoS; Validated
42-299 3.99e-24

RNA polymerase sigma factor RpoS; Validated


Pssm-ID: 235548 [Multi-domain]  Cd Length: 325  Bit Score: 100.03  E-value: 3.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  42 EIGNYQVLSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFNPALGYC 121
Cdd:PRK05657   61 EIGYSPLLTAEEEVYFARRALRGDFAARQRMIESNLRLVVKIAKRYLNR--GLALLDLIEEGNLGLIRAVEKFDPERGFR 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 122 FSTYAFWWI-QKRMLGIICKKRSgpFKIPNYV----NQFNLKYVELEDKylqmYNRPPSVEEVVKELDVTSEIVIRHNVY 196
Cdd:PRK05657  139 FSTYATWWIrQTIERAIMNQTRT--IRLPVHVvkelNVYLRAARELEHK----LDHEPSAEEIAELLDKPVDDVSRMLAL 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 197 YKRATTM--TLDIDTineDIGISNSSHDDKSAIPsiNEMVIEDlnyEI------WLifdEVLNPKQKMVLNLCFGLLDGK 268
Cdd:PRK05657  213 NERITSLdtPLGGDP---EKSLLDILADEQENGP--EDTTQDD---DMkqsivkWL---FELNDKQREVLARRFGLLGYE 281
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1209279056 269 VYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:PRK05657  282 AATLEDVAREIGLTRERVRQIQVEALRRLRE 312
PRK07921 PRK07921
RNA polymerase sigma factor SigB; Reviewed
69-304 1.77e-23

RNA polymerase sigma factor SigB; Reviewed


Pssm-ID: 181169 [Multi-domain]  Cd Length: 324  Bit Score: 98.26  E-value: 1.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  69 RDYLFHVNVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWI-QKRMLGIICKKRSgpFK 147
Cdd:PRK07921   88 RRHLLEANLRLVVSLAKRYTGR--GMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIrQAITRGMADQSRT--IR 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 148 IP-NYVNQFNlKYVELEDKYLQMYNRPPSVEEVVKELDVTSEivirhnvyyKRATTMTLDIDTINEDIGISNSSH----- 221
Cdd:PRK07921  164 LPvHLVEQVN-KLARIKRELHQQLGREATDEELAEESGIPEE---------KIADLLEHSRDPVSLDMPVGSDEEaplgd 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 222 --DDKSAIPSINEMVIEDLNYEIWLIFDeVLNPKQKMVLNLCFGLLDGKVYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:PRK07921  234 fiEDSEATSAENAVIAGLLHTDIRSVLA-TLDEREQQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQIEREVMSKLRN 312

                  ....*
gi 1209279056 300 CDYKD 304
Cdd:PRK07921  313 GERAD 317
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
69-298 2.71e-22

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 96.99  E-value: 2.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  69 RDYLFHVNVGLVLSIARKYKNKHPDieFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWI----------QKRmlgII 138
Cdd:PRK05901  273 KNHLLEANLRLVVSLAKRYTNRGLS--FLDLIQEGNLGLIKAVEKFDYTKGYKFSTYATWWIrqaitramadQAR---TI 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 139 ckkrsgpfKIP-NYVNQFNlKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIVirhnVYYKRattmtLDIDTINED--IG 215
Cdd:PRK05901  348 --------RIPvHMVETIN-KLGRIERELLQELGREPTPEELAKEMGFTPEKV----REIQK-----YNREPISLDktIG 409
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 216 ISNSSH-----DDKSAIpSINEMVIEDLNYEiwlIFDEVLN---PKQKMVLNLCFGLLDGKVYLHKEIAKALMITTERVS 287
Cdd:PRK05901  410 KEGDSQfgdfiEDSEAV-SPVDAVSFTLLQD---QLQEVLEtlsEREAGVIRMRFGLTDGQPKTLDEIGQVYGVTRERIR 485
                         250
                  ....*....|.
gi 1209279056 288 QIKEEAIKKLK 298
Cdd:PRK05901  486 QIESKTLRKLR 496
PRK07406 PRK07406
RNA polymerase sigma factor RpoD; Validated
60-298 5.30e-20

RNA polymerase sigma factor RpoD; Validated


Pssm-ID: 236012 [Multi-domain]  Cd Length: 373  Bit Score: 89.46  E-value: 5.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  60 RYKHGEKdLRDYLFHVNVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIIC 139
Cdd:PRK07406  130 RLMLGRR-AKEKMVQSNLRLVVSIAKKYMNR--GLSFQDLIQEGSLGLIRAAEKFDHEKGYKFSTYATWWIRQAITRAIA 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 140 KKrSGPFKIPNYVNQfNLKYVELEDKYL-QMYNRPPSVEEVVKELDVTSEIVirhnvyykR--ATTMTLDI--------- 207
Cdd:PRK07406  207 DQ-SRTIRLPVHLYE-TISRIKKTTKVLsQEFGRKPTEEEIAESMEMTIEKL--------RfiAKSAQLPIsletpigke 276
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 208 ------DTINEDIgisNSSHDDKSaipsiNEMVIEDLnyEIWLifdEVLNPKQKMVLNLCFGLLDGKVYLHKEIAKALMI 281
Cdd:PRK07406  277 edsrlgDFIEADG---ETPEDDVA-----KNLLREDL--EGVL---ATLSPRERDVLRLRYGLDDGRMKTLEEIGQIFNV 343
                         250
                  ....*....|....*..
gi 1209279056 282 TTERVSQIKEEAIKKLK 298
Cdd:PRK07406  344 TRERIRQIEAKALRKLR 360
FliA_WhiG TIGR02479
RNA polymerase sigma factor, FliA/WhiG family; Most members of this family are the flagellar ...
79-300 4.66e-18

RNA polymerase sigma factor, FliA/WhiG family; Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.


Pssm-ID: 274153 [Multi-domain]  Cd Length: 224  Bit Score: 81.55  E-value: 4.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  79 LVLSIARKYKNKHPD-IEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIICKKRSGPFKIPNYVNQFNL 157
Cdd:TIGR02479   8 LVKRIAGRLSVGLPSsVELDDLIQAGMFGLLDAIERYDPSRGAKFETYAVQRIRGAMLDELRRLDWVPRSLRQKARKLER 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 158 KYVELEdkylQMYNRPPSVEEVVKELDVTSEIVirHNVYYKRATTMTLDIDTINEDIGISNSSHD---DKSAIPSINEMV 234
Cdd:TIGR02479  88 AIRELE----ARLGREPTEEEIAEELGMDLKEY--RQALNEINALSLVSLDELLESGDDGGSLIDrieDDKSEDPEEELE 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 235 IEDLNYEIWLIFDEvLNPKQKMVLNLcfglldgkVYLH----KEIAKALMITTERVSQIKEEAIKKLKKC 300
Cdd:TIGR02479 162 REELREALAEAIES-LSEREQLVLSL--------YYYEelnlKEIGEVLGLTESRVSQIHSQALKKLRAK 222
PRK08215 PRK08215
RNA polymerase sporulation sigma factor SigG;
48-299 2.15e-17

RNA polymerase sporulation sigma factor SigG;


Pssm-ID: 181296 [Multi-domain]  Cd Length: 258  Bit Score: 80.38  E-value: 2.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  48 VLSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKHPDIefDDLVQEGNEGMLRAMEDFNPALGYCFSTYAF 127
Cdd:PRK08215   18 VLKNEEMRELFERMQNGDKEAREKLINGNLRLVLSVIQRFNNRGENV--DDLFQVGCIGLMKAIDNFDLSQNVKFSTYAV 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 128 WWIQ---KRMLgiickKRSGPFKIPNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIVIrhnvyykrattmt 204
Cdd:PRK08215   96 PMIIgeiRRYL-----RDNNPIRVSRSLRDIAYKALQVREKLINENSKEPTVEEIAKELEVPREEVV------------- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 205 LDIDTINEDIGISNS-SHDDKSAIPSINEMVIEDLNYEIWLifDEV--------LNPKQKMVLNLCFglLDGKVYLhkEI 275
Cdd:PRK08215  158 FALDAIQDPVSLFEPiYHDGGDPIYVMDQISDEKNKDENWL--EEIalkeamkkLNDREKLILNLRF--FQGKTQM--EV 231
                         250       260
                  ....*....|....*....|....
gi 1209279056 276 AKALMITTERVSQIKEEAIKKLKK 299
Cdd:PRK08215  232 AEEIGISQAQVSRLEKAALKHMRK 255
rpoH_proteo TIGR02392
alternative sigma factor RpoH; A sigma factor is a DNA-binding protein protein that binds to ...
40-300 2.23e-16

alternative sigma factor RpoH; A sigma factor is a DNA-binding protein protein that binds to the DNA-directed RNA polymerase core to produce the holoenzyme capable of initiating transcription at specific sites. Different sigma factors act in vegetative growth, heat shock, extracytoplasmic functions (ECF), etc. This model represents the clade of sigma factors called RpoH and further restricted to the Proteobacteria. This protein may be called sigma-32, sigma factor H, heat shock sigma factor, and alternative sigma factor RpoH. Note that in some species the single locus rpoH may be replaced by two or more differentially regulated stress response sigma factors. [Cellular processes, Adaptations to atypical conditions, Transcription, Transcription factors]


Pssm-ID: 274107 [Multi-domain]  Cd Length: 270  Bit Score: 77.71  E-value: 2.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  40 IKEIGNYQVLSKQESLNLFQRYK-HGEKDLRDYLFHVNVGLVLSIARKYKN---KHPDiefddLVQEGNEGMLRAMEDFN 115
Cdd:TIGR02392   7 IRAVNRIPMLTPEEEYQLAKRLReHGDLDAAKKLVLSHLRFVVKIARGYRGyglPQAD-----LIQEGNIGLMKAVKRFD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 116 PALGYCFSTYAFWWIQKRMLGIICKKRSgPFKIPNYVNQ----FNLKYVEledKYLQMYNRPPSVEEVVKELDVTSEIVI 191
Cdd:TIGR02392  82 PERGVRLVSFAVHWIKAEIHEYILRNWR-LVKVATTKAQrklfFNLRKMK---KRLQGWLNPEEVEAIAEELGVSEREVR 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 192 RHNVYYkRATTMTLDidtinedigISNSSHDDKSAIPsINEMVIEDLNYEIWLIFDEVLNPKQKMVLNLCFGL------- 264
Cdd:TIGR02392 158 EMESRL-SGQDMSLN---------ASIDDDEDDGGAP-IAYLVDKRSDPEDTLEEEQWEELQRQALANALGSLdarsrri 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1209279056 265 ------LDGKVYLHkEIAKALMITTERVSQIKEEAIKKLKKC 300
Cdd:TIGR02392 227 iearwlDDDKLTLQ-ELAAEYGVSAERIRQIEKNAMKKLKAA 267
PRK05803 PRK05803
RNA polymerase sporulation sigma factor SigK;
29-305 1.92e-15

RNA polymerase sporulation sigma factor SigK;


Pssm-ID: 180266 [Multi-domain]  Cd Length: 233  Bit Score: 74.21  E-value: 1.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  29 PMAYPEGNTFEikeignyQVLSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKHPDIefDDLVQEGNEGML 108
Cdd:PRK05803   18 LVSYVKNNSFP-------QPLSEEEERKYLELMKEGDEEARNILIERNLRLVAHIVKKFENTGEDV--DDLISIGTIGLI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 109 RAMEDFNPALGYCFSTYAFWWIQKRMLGIIckkRSgpfkipnyvNQFNLKYVELEDkylqmynrPPSVEevvKEldvTSE 188
Cdd:PRK05803   89 KAIESFDAGKGTKLATYAARCIENEILMHL---RN---------LKKTKKEVSLQD--------PIGVD---KE---GNE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 189 IVIrhnvyykrattmtLDIDTINEDigisnsshddksaipSINEMVieDLNYEIWLIFD--EVLNPKQKMVLNLCFGLLD 266
Cdd:PRK05803  143 ISL-------------IDILGSEED---------------DVIEQV--ELKMEVEKLYKkiDILDEREKEVIEMRYGLGN 192
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1209279056 267 GKVYLHKEIAKALMITTERVSQIKEEAIKKLKKCDYKDE 305
Cdd:PRK05803  193 GKEKTQREIAKALGISRSYVSRIEKRALKKLFKELYRAE 231
Sigma70_r2 pfam04542
Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. ...
72-135 5.60e-14

Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant. The core binding helix, interacts with the clamp domain of the largest polymerase subunit, beta prime. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation.


Pssm-ID: 427998 [Multi-domain]  Cd Length: 71  Bit Score: 66.07  E-value: 5.60e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1209279056  72 LFHVNVGLVLSIARKYKNKHPDIEfdDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRML 135
Cdd:pfam04542   1 LVERYLPLVYSLARRYLGDGADAE--DLVQEGFLGLWRAIERFDPERGVSFSTWLYTIIRNAII 62
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
67-300 1.26e-13

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 67.37  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  67 DLRDYLFHVNVGLVLSIARKYKNKHPDIEfdDLVQEGNEGMLRAMEDFNPalGYCFSTYAFWWIQKRMLGIICKKRsgpf 146
Cdd:TIGR02937   1 EAFEELYERYLPLVYRYARRYLGDDADAE--DLVQEAFLKLLEALDRFDP--EGSFKAWLFRIARNLILDYLRRKR---- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 147 kipnyvnqfnlKYVELEDKYLQMYNRPPSVEEvvkeldvtseivirhnvyykrattmtldidtinedigisnsshddksa 226
Cdd:TIGR02937  73 -----------RLRRELDLLEELLDSDPSPEE------------------------------------------------ 93
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1209279056 227 ipsinEMVIEDLNYEIWLIFDEvLNPKQKMVLNLCFglLDGkvYLHKEIAKALMITTERVSQIKEEAIKKLKKC 300
Cdd:TIGR02937  94 -----ELEQEEEREALREALEK-LPEREREVLVLRY--LEG--LSYKEIAEILGISVGTVKRRLKRARKKLREL 157
PRK07408 PRK07408
RNA polymerase sigma factor SigF; Reviewed
51-188 1.82e-13

RNA polymerase sigma factor SigF; Reviewed


Pssm-ID: 180965 [Multi-domain]  Cd Length: 256  Bit Score: 69.18  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  51 KQESLNLFQRYKHGEK-DLRDYLFHVNVGLVLSIARKYKNKHPDiEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWW 129
Cdd:PRK07408    8 KSETMELLRAYQQNPSiALRNQLVELNLGLVRKEAHRWSNQCSE-PYEDLVQVGSLGLIRAIERFDPSKGHAFSSFAIPY 86
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1209279056 130 IQKRMLGIIcKKRSGPFKIPNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSE 188
Cdd:PRK07408   87 IRGEIQHYL-RDKSPTVRIPRRWQELQRQAKKVRQELRQELGRQPTDQEIAQALDISLE 144
PRK05658 PRK05658
RNA polymerase sigma factor RpoD; Validated
39-298 1.17e-12

RNA polymerase sigma factor RpoD; Validated


Pssm-ID: 235549 [Multi-domain]  Cd Length: 619  Bit Score: 68.28  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  39 EIKEIGNYQVLSKQESLNLFQRYKHGEKDLR---DYLFHVNVGLVLSIARKYKNKhpDIEFDDLVQEGNEGMLRAMEDFN 115
Cdd:PRK05658  349 ELEAIEEETGLTIEELKEINRQISKGEAKARrakKEMVEANLRLVISIAKKYTNR--GLQFLDLIQEGNIGLMKAVDKFE 426
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 116 PALGYCFSTYAFWWI----------QKRMLgiickkrsgpfKIP-NYVNQFNlKYVELEDKYLQMYNRPPSVEEVVKELD 184
Cdd:PRK05658  427 YRRGYKFSTYATWWIrqaitrsiadQARTI-----------RIPvHMIETIN-KLNRISRQMLQEIGREPTPEELAERLG 494
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 185 vtseivirhnvyykrattMTLD-IDTI----------------NEDigisnsSH-----DDKSAIPSINEMVIEDLNYEI 242
Cdd:PRK05658  495 ------------------MPEDkVRKVlkiakepisletpigdDED------SHlgdfiEDKNAELPIDAAIQESLREAT 550
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1209279056 243 wlifDEV---LNPKQKMVLNLCFGLLDGkvYLH--KEIAKALMITTERVSQIKEEAIKKLK 298
Cdd:PRK05658  551 ----TDVlasLTPREAKVLRMRFGIDMN--TDHtlEEVGKQFDVTRERIRQIEAKALRKLR 605
PRK06596 PRK06596
RNA polymerase factor sigma-32; Reviewed
24-300 1.61e-12

RNA polymerase factor sigma-32; Reviewed


Pssm-ID: 235838 [Multi-domain]  Cd Length: 284  Bit Score: 66.74  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  24 ARSIKPMAYPEGNTFE--IKEIGNYQVLSKQESLNLFQRYK-HGEKD---------LRdylfhvnvgLVLSIARKYKnkH 91
Cdd:PRK06596    2 TKALQLLALSPEGNLDayIQAVNKIPMLTAEEEYMLAKRLReHGDLEaakqlvlshLR---------FVVHIARGYR--G 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  92 PDIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIqkrmlgiickKRSgpfkIPNYV-------------NQ---- 154
Cdd:PRK06596   71 YGLPQADLIQEGNIGLMKAVKRFDPEVGVRLVSFAVHWI----------KAE----IHEYIlrnwrivkvattkAQrklf 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 155 FNLKYVEledKYLQMYNrPPSVEEVVKELDVTSEIVIRHNvyyKR--ATTMTLDIdTINEDIGISNSSHD---DKSAIPs 229
Cdd:PRK06596  137 FNLRKAK---KRLGWLN-PEEVEMVAEELGVSEEEVREME---SRlsGQDASLDA-PIDDDDEESGAPQDyleDKSSDP- 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1209279056 230 inEMVIEDLNYEIW---LIFD--EVLNPKQKMVLNlCFGLLDGKVYLHkEIAKALMITTERVSQIKEEAIKKLKKC 300
Cdd:PRK06596  208 --ADVLEEDNWEDQrraLLADalEGLDERSRDIIE-ARWLDDDKSTLQ-ELAAEYGVSAERVRQIEKNAMKKLKAA 279
fliA PRK06986
flagellar biosynthesis sigma factor; Validated
61-300 2.51e-12

flagellar biosynthesis sigma factor; Validated


Pssm-ID: 235901 [Multi-domain]  Cd Length: 236  Bit Score: 65.25  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  61 YKHGEKDLRDYLFHVNVGLVLSIARKYKNKHP-DIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKRMLGIIc 139
Cdd:PRK06986    2 YTAEGKMDQDELVEQYAPLVKRIALRLKARLPaSVDLDDLIQAGMIGLLEAARRYDGEQGASFETYAGQRIRGAMLDEL- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 140 kkRSGPFkIPNYVNQfNLKYVELE-DKYLQMYNRPPSVEEVVKELDVTSE----IVIRHNVYykraTTMTLD-IDTINED 213
Cdd:PRK06986   81 --RSLDW-VPRSVRR-NAREVAQAiRQLEQELGREPTDTEVAEKLGLSLEeyreMLLDTNIS----QLFSIDeLRGEHGD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 214 IGISNSSHDDKSAIPSI-NEMVIEDLNYEIwlifdEVLNPKQKMVLNLcfglldgkvYLH-----KEIAKALMITTERVS 287
Cdd:PRK06986  153 SILVTEDHQDEDPLQQLeDEELREALVEAI-----ESLPEREQLVLSL---------YYQeelnlKEIGAVLGVSESRVS 218
                         250
                  ....*....|...
gi 1209279056 288 QIKEEAIKKLKKC 300
Cdd:PRK06986  219 QIHSQAIKRLRAR 231
PRK07670 PRK07670
FliA/WhiG family RNA polymerase sigma factor;
57-299 1.71e-10

FliA/WhiG family RNA polymerase sigma factor;


Pssm-ID: 181075 [Multi-domain]  Cd Length: 251  Bit Score: 60.44  E-value: 1.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  57 LFQRYKH------GEKDLRDYLFHVN-------VGLVLSIARkyknkhpdiefDDLVQEGNEGMLRAMEDFNPALGYCFS 123
Cdd:PRK07670   11 LWDRWKEerdpdaADELIRRYMPLVHyhvqrisVGLPKSVSK-----------DDLKSLGMLGLYDALEKFDPSRDLKFD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 124 TYAFWWIQKRMLGIICKK----RSGPFKIpnyvnqfnlKYVE-LEDKYLQMYNRPPSVEEVVKELDVTSEIVirhnvyyk 198
Cdd:PRK07670   80 TYASFRIRGAIIDGLRKEdwlpRSMREKT---------KKVEaAIEKLEQRYMRNVTPKEVAAELGMTEEEV-------- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 199 rATTM-------TLDID---TINEDI-GISNSSHDDKSAIPS---INEMVIEDLNYEIwlifdEVLNPKQKMVLNLcfgl 264
Cdd:PRK07670  143 -EATMnegffanLLSIDektHDQDDGeNVSVTIRDDKTPTPEeklLKEELIEELAEKI-----KQLSEKEQLVISL---- 212
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1209279056 265 ldgkVYLHK----EIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:PRK07670  213 ----FYKEEltltEIGQVLNLSTSRISQIHSKALFKLKK 247
rpoH2 PRK07500
RNA polymerase factor sigma-32; Reviewed
49-134 2.09e-10

RNA polymerase factor sigma-32; Reviewed


Pssm-ID: 236033 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  49 LSKQESLNLFQRYK-HGEKDLRDYLFHVNVGLVLSIARKYKN-KHPdieFDDLVQEGNEGMLRAMEDFNPALGYCFSTYA 126
Cdd:PRK07500   21 LEREEEHALAYRWKdHRDEDALHRIISAHMRLVISMAGKFRRfGLP---MNDLIQEGYVGLLEAAARFEPDREVRFSTYA 97

                  ....*...
gi 1209279056 127 FWWIQKRM 134
Cdd:PRK07500   98 TWWIRASI 105
PRK06288 PRK06288
RNA polymerase sigma factor WhiG; Reviewed
57-298 1.94e-09

RNA polymerase sigma factor WhiG; Reviewed


Pssm-ID: 235770 [Multi-domain]  Cd Length: 268  Bit Score: 57.39  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  57 LFQRYKH-GEKDLRDYLFHVNVGLVLSIARKYK-NKHPDIEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFwwiqKRM 134
Cdd:PRK06288   20 LWREYKKtGDPKIREYLILKYSPLVKYVAGRIAvGMPQNVEFDDLVSYGVFGLIDAIEKFDPEREIKFKTYAV----TRI 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 135 LGIICKKRSGPFKIPNYVNQfnlKYVELEDKYLQMYN---RPPSVEEVVKELDVTSEIVirHNVYYKRATTMTLDIDTI- 210
Cdd:PRK06288   96 RGAIFDELRSIDWIPRSVRQ---KARQIERAIAMLEArlgRTPSDEEIADELGISLEEY--NSLLSKLSGTSVVSLNDLw 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 211 -----NEDIGISNSSHDDKSAIPsinEMVIEDlnYEIWLIFDEVLNP---KQKMVLNLCF--GLldgkvyLHKEIAKALM 280
Cdd:PRK06288  171 fggdeGDEVSLMDTLESPAALNP---DEIAER--EEIKRVIVEAIKTlpeREKKVLILYYyeDL------TLKEIGKVLG 239
                         250
                  ....*....|....*...
gi 1209279056 281 ITTERVSQIKEEAIKKLK 298
Cdd:PRK06288  240 VTESRISQLHTKAVLQLR 257
PRK08583 PRK08583
RNA polymerase sigma factor SigB; Validated
49-298 7.69e-09

RNA polymerase sigma factor SigB; Validated


Pssm-ID: 236306 [Multi-domain]  Cd Length: 257  Bit Score: 55.47  E-value: 7.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  49 LSKQESLNLFQRY-KHGEKDLRDYLFHVNVGLVLSIARKY-KNKHPDiefDDLVQEGNEGMLRAMEDFNPALGYCFSTYA 126
Cdd:PRK08583   10 LTKEEVNKWIAEYqENQDEEAQEKLVKHYKNLVESLAYKYsKGQSHH---EDLVQVGMVGLLGAIRRYDPSFGRSFEAFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 127 FWWIQ---KRML-----GIICKKRS---GPfKIPNYVNQFNlkyVELEdkylqmynRPPSVEEVVKELDVTSEIVIrhnv 195
Cdd:PRK08583   87 VPTIIgeiKRYLrdktwSVHVPRRIkelGP-KIKKAVDELT---TELQ--------RSPKISEIADRLGVSEEEVL---- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 196 yykRATTMTLDIDTINEDIGISNSShdDKSAIPSINEMVIEDLNYE-------IWLIFdEVLNPKQKMVLNLCFglLDGK 268
Cdd:PRK08583  151 ---EAMEMGKSYQALSVDHSIEADS--DGSTVTLLDIVGQQEDGYElteqrmiLEKIL-PVLSDREKSIIQCTF--IENL 222
                         250       260       270
                  ....*....|....*....|....*....|
gi 1209279056 269 VylHKEIAKALMITTERVSQIKEEAIKKLK 298
Cdd:PRK08583  223 S--QKETGERLGISQMHVSRLQRQAIKKLR 250
PRK05911 PRK05911
RNA polymerase sigma factor sigma-28; Reviewed
65-298 1.60e-08

RNA polymerase sigma factor sigma-28; Reviewed


Pssm-ID: 235644 [Multi-domain]  Cd Length: 257  Bit Score: 54.62  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056  65 EKDLRDYLFHVNVGLVLSIARKYKNKHPD-IEFDDLVQEGNEGMLRAMEDFNPALGYCFSTYAFWWIQKrmlGIICKKRS 143
Cdd:PRK05911   21 EIEYRDVLIEFYLPLVKNVAHRLISGMPShVKTEDLYASGVEGLVRAVERFDPEKSRRFEGYALFLIKA---AIIDDLRK 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 144 GPFkIPNYVNQFNLKYVELEDKYLQMYNRPPSVEEVVKELDVTSEIVIRHNVYYKRATTMTLdidtiNEDigisNSSHDD 223
Cdd:PRK05911   98 QDW-VPRSVHQKANKLADAMDSLRQSLGKEPTDGELCEYLNISQQELSGWFSSARPALILSL-----NEE----FPCQSD 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209279056 224 KSAIPSINEMVIEDLNYEIWLIFD------------EVLNPKQKMVLNLCFglLDGKVYlhKEIAKALMITTERVSQIKE 291
Cdd:PRK05911  168 DEAGLALEERIADERAETGYDVVDkkefssilaeaiLALEEKERKVMALYY--YEELVL--KEIGKILGVSESRVSQIHS 243

                  ....*..
gi 1209279056 292 EAIKKLK 298
Cdd:PRK05911  244 KALLKLR 250
Sigma70_r4 pfam04545
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
248-299 1.21e-07

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.


Pssm-ID: 461347 [Multi-domain]  Cd Length: 50  Bit Score: 47.42  E-value: 1.21e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1209279056 248 EVLNPKQKMVLNLCFGlldgKVYLHKEIAKALMITTERVSQIKEEAIKKLKK 299
Cdd:pfam04545   3 ASLPPRERQVLVLRYG----EGLTLEEIGERLGISRERVRQIEKRALRKLRK 50
Sigma70_r4 cd06171
Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in ...
248-298 1.12e-05

Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or plastid core RNA polymerase to specific promoter elements located upstream of transcription initiation points. The SR4 of Ec sigma70 and other essential primary SFs contact promoter sequences located 35 base-pairs upstream of the initiation point, recognizing a 6-base-pair -35 consensus TTGACA. Sigma70 related SFs also include SFs which are dispensable for bacterial cell growth for example Ec sigmaS, SFs which activate regulons in response to a specific signal for example heat-shock Ec sigmaH, and a group of SFs which includes the extracytoplasmic function (ECF) SFs and is typified by Ec sigmaE which contains SR2 and -4 only. ECF SFs direct the transcription of genes that regulate various responses including periplasmic stress and pathogenesis. Ec sigmaE SR4 also contacts the -35 element, but recognizes a different consensus (a 7-base-pair GGAACTT). Plant SFs recognize sigma70 type promoters and direct transcription of the major plastid RNA polymerase, plastid-encoded RNA polymerase (PEP).


Pssm-ID: 100119 [Multi-domain]  Cd Length: 55  Bit Score: 42.09  E-value: 1.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1209279056 248 EVLNPKQKMVLNLCFGllDGKVYlhKEIAKALMITTERVSQIKEEAIKKLK 298
Cdd:cd06171     9 DKLPEREREVILLRFG--EGLSY--EEIAEILGISRSTVRQRLHRALKKLR 55
PRK08301 PRK08301
RNA polymerase sporulation sigma factor SigE;
49-126 4.06e-05

RNA polymerase sporulation sigma factor SigE;


Pssm-ID: 236228 [Multi-domain]  Cd Length: 234  Bit Score: 44.08  E-value: 4.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1209279056  49 LSKQESLNLFQRYKHGEKDLRDYLFHVNVGLVLSIARKYKNKHPDIEfdDLVQEGNEGMLRAMEDFNPALGYCFSTYA 126
Cdd:PRK08301   34 LSKEEEEYLLNKLPKGDEAVRSLLIERNLRLVVYIARKFENTGINIE--DLISIGTIGLIKAVNTFNPEKKIKLATYA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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