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Conserved domains on  [gi|1209303788|ref|WP_088348880|]
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MULTISPECIES: methyltransferase domain-containing protein [Rhodomicrobium]

Protein Classification

methyltransferase domain-containing protein( domain architecture ID 1002315)

methyltransferase domain-containing protein similar to vertebrate mitochondrial arginine-hydroxylase NDUFAF5 and bacterial malonyl-[acyl-carrier protein] O-methyltransferase

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BioC super family cl37044
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 31-260 7.09e-25

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


The actual alignment was detected with superfamily member TIGR02072:

Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 99.67  E-value: 7.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788  31 RRAAEDMAERLQGV-ERSFARILNIGAHHGILAAALKAAHSAADLvINMEASAPLLALC---GSPKVR---ADEEALPFR 103
Cdd:TIGR02072  17 REMAKRLLALLKEKgIFIPASVLDIGCGTGYLTRALLKRFPQAEF-IALDISAGMLAQAktkLSENVQficGDAEKLPLE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 104 DGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQaeveleggISPRVAPMADIRDfggl 183
Cdd:TIGR02072  96 DSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQ--------HGLRYLSLDELKA---- 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1209303788 184 LQRAGFALPVADADLVAVTYSSPLALMLELRAMGAGNVLTERRKRPmrratLTRAM-EIYAERFPASGgrVAATFEII 260
Cdd:TIGR02072 164 LLKNSFELLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGRTSRK-----QLKAFlERYEQEFQPDG--LPLTYHVV 234
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 31-260 7.09e-25

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 99.67  E-value: 7.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788  31 RRAAEDMAERLQGV-ERSFARILNIGAHHGILAAALKAAHSAADLvINMEASAPLLALC---GSPKVR---ADEEALPFR 103
Cdd:TIGR02072  17 REMAKRLLALLKEKgIFIPASVLDIGCGTGYLTRALLKRFPQAEF-IALDISAGMLAQAktkLSENVQficGDAEKLPLE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 104 DGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQaeveleggISPRVAPMADIRDfggl 183
Cdd:TIGR02072  96 DSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQ--------HGLRYLSLDELKA---- 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1209303788 184 LQRAGFALPVADADLVAVTYSSPLALMLELRAMGAGNVLTERRKRPmrratLTRAM-EIYAERFPASGgrVAATFEII 260
Cdd:TIGR02072 164 LLKNSFELLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGRTSRK-----QLKAFlERYEQEFQPDG--LPLTYHVV 234
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-140 7.52e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 60.37  E-value: 7.52e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1209303788  75 VINMEASAPLLALC-------GSPKVRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFL 140
Cdd:pfam08241  21 VTGVDISPEMLELArekapreGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILI 93
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 93-159 1.51e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.16  E-value: 1.51e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1209303788  93 VRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQA 159
Cdd:COG2226    74 VVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA 140
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 27-237 3.48e-08

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 53.22  E-value: 3.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788  27 DFLLRRAAEDMAERLQGveRSFARILNIGAHHGILAAALKAAHSAadlVINMEASAPLLALCGSPK-----VRADEEALP 101
Cdd:PRK10258   24 AELQRQSADALLAMLPQ--RKFTHVLDAGCGPGWMSRYWRERGSQ---VTALDLSPPMLAQARQKDaadhyLAGDIESLP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 102 FRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQAEvelEGGISPRVAPMADIRDfg 181
Cdd:PRK10258   99 LATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVD---ERPHANRFLPPDAIEQ-- 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 182 gllqragfALPVADADL----VAVTYSSPLALMLELRAMGAGNVLTERRKRPMRRATLTR 237
Cdd:PRK10258  174 --------ALNGWRYQHhiqpITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQR 225
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-140 8.55e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 8.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1209303788  97 EEALPFRDGAFDLVASALSLQ-FVNDLPGALIQIRRALKPDGLFL 140
Cdd:cd02440    57 EELPPEADESFDVIISDPPLHhLVEDLARFLEEARRLLKPGGVLV 101
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 31-260 7.09e-25

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 99.67  E-value: 7.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788  31 RRAAEDMAERLQGV-ERSFARILNIGAHHGILAAALKAAHSAADLvINMEASAPLLALC---GSPKVR---ADEEALPFR 103
Cdd:TIGR02072  17 REMAKRLLALLKEKgIFIPASVLDIGCGTGYLTRALLKRFPQAEF-IALDISAGMLAQAktkLSENVQficGDAEKLPLE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 104 DGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQaeveleggISPRVAPMADIRDfggl 183
Cdd:TIGR02072  96 DSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQ--------HGLRYLSLDELKA---- 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1209303788 184 LQRAGFALPVADADLVAVTYSSPLALMLELRAMGAGNVLTERRKRPmrratLTRAM-EIYAERFPASGgrVAATFEII 260
Cdd:TIGR02072 164 LLKNSFELLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGRTSRK-----QLKAFlERYEQEFQPDG--LPLTYHVV 234
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-140 7.52e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 60.37  E-value: 7.52e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1209303788  75 VINMEASAPLLALC-------GSPKVRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFL 140
Cdd:pfam08241  21 VTGVDISPEMLELArekapreGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILI 93
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 93-159 1.51e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.16  E-value: 1.51e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1209303788  93 VRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQA 159
Cdd:COG2226    74 VVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA 140
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 27-237 3.48e-08

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 53.22  E-value: 3.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788  27 DFLLRRAAEDMAERLQGveRSFARILNIGAHHGILAAALKAAHSAadlVINMEASAPLLALCGSPK-----VRADEEALP 101
Cdd:PRK10258   24 AELQRQSADALLAMLPQ--RKFTHVLDAGCGPGWMSRYWRERGSQ---VTALDLSPPMLAQARQKDaadhyLAGDIESLP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 102 FRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQAEvelEGGISPRVAPMADIRDfg 181
Cdd:PRK10258   99 LATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVD---ERPHANRFLPPDAIEQ-- 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 182 gllqragfALPVADADL----VAVTYSSPLALMLELRAMGAGNVLTERRKRPMRRATLTR 237
Cdd:PRK10258  174 --------ALNGWRYQHhiqpITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQR 225
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 93-137 8.16e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.10  E-value: 8.16e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1209303788  93 VRADEEALPFRDGAFDLVASALSLQFVN--DLPGALIQIRRALKPDG 137
Cdd:pfam13649  50 VQGDAEDLPFPDGSFDLVVSSGVLHHLPdpDLEAALREIARVLKPGG 96
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 30-191 1.11e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 47.81  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788  30 LRRAAEDMAERLQGVERSFARILNIGAHHGILAAALKAAHSAadlVINMEAS--APLLALCGSPKVRADEEALPFRDGAF 107
Cdd:pfam13489   5 RERLLADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFS---VTGVDPSpiAIERALLNVRFDQFDEQEAAVPAGKF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788 108 DLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVLGGATLQELRLSFAQAEVELEGGISPRvapmaDIRDFGGLLQRA 187
Cdd:pfam13489  82 DVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPRNGHISLF-----SARSLKRLLEEA 156


                  ....
gi 1209303788 188 GFAL 191
Cdd:pfam13489 157 GFEV 160
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 93-140 1.31e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 46.55  E-value: 1.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1209303788  93 VRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFL 140
Cdd:COG2227    74 VQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLL 121
PRK08317 PRK08317
hypothetical protein; Provisional
 93-137 1.47e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 48.39  E-value: 1.47e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1209303788  93 VRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDG 137
Cdd:PRK08317   74 VRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGG 118
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
93-140 7.29e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 7.29e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1209303788  93 VRADEEALPFrDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFL 140
Cdd:COG4106    51 VVADLRDLDP-PEPFDLVVSNAALHWLPDHAALLARLAAALAPGGVLA 97
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
93-162 1.07e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 44.99  E-value: 1.07e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209303788  93 VRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFLGAVlgGATLQELRLSFAQAEVE 162
Cdd:COG4976    94 LVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSV--EDADGSGRYAHSLDYVR 161
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
93-140 2.10e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 44.74  E-value: 2.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1209303788  93 VRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFL 140
Cdd:pfam01209  98 LQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVV 145
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 91-140 4.85e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.60  E-value: 4.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1209303788  91 PKVRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFL 140
Cdd:PRK00216  106 EFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLV 155
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 91-140 1.21e-04

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 42.63  E-value: 1.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1209303788  91 PKVRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRRALKPDGLFL 140
Cdd:TIGR01934  91 EFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLV 140
PRK05785 PRK05785
hypothetical protein; Provisional
 84-131 2.48e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 38.52  E-value: 2.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1209303788  84 LLALCGSPKVRADEEALPFRDGAFDLVASALSLQFVNDLPGALIQIRR 131
Cdd:PRK05785   88 KMNLVADDKVVGSFEALPFRDKSFDVVMSSFALHASDNIEKVIAEFTR 135
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 91-139 2.59e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.58  E-value: 2.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1209303788  91 PKVRADEEALPFRDG-AFDLVASALSLQFVNDLPGALIQIRRALKPDGLF 139
Cdd:pfam08242  49 VRVELFQLDLGELDPgSFDVVVASNVLHHLADPRAVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-140 8.55e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 8.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1209303788  97 EEALPFRDGAFDLVASALSLQ-FVNDLPGALIQIRRALKPDGLFL 140
Cdd:cd02440    57 EELPPEADESFDVIISDPPLHhLVEDLARFLEEARRLLKPGGVLV 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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