NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1212733095|ref|WP_088610078|]
View 

GntR family transcriptional regulator [Bacillus sp. K2I17]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-221 2.04e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 176.27  E-value: 2.04e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   1 MPIPQDYKkqgRVSAKSLVLNQLQDWIIEGVLQPDEKINDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPI 80
Cdd:COG1802     1 MTSPSPLR---RESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  81 KLDDIPIIYETMAGLHSIIGKQALQNITDADLKLLSEINADFQRSIEKKNAKQALKLDIQFHNTISSIAKNQYIEPFLEN 160
Cdd:COG1802    78 SPEEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRR 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212733095 161 MQLHVLRLEYLFFQNFVPASQSIEEHHSIIQALQKQDEKQMEQMMSQNWLRPMKEISKIIS 221
Cdd:COG1802   158 LRARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-221 2.04e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 176.27  E-value: 2.04e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   1 MPIPQDYKkqgRVSAKSLVLNQLQDWIIEGVLQPDEKINDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPI 80
Cdd:COG1802     1 MTSPSPLR---RESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  81 KLDDIPIIYETMAGLHSIIGKQALQNITDADLKLLSEINADFQRSIEKKNAKQALKLDIQFHNTISSIAKNQYIEPFLEN 160
Cdd:COG1802    78 SPEEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRR 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212733095 161 MQLHVLRLEYLFFQNFVPASQSIEEHHSIIQALQKQDEKQMEQMMSQNWLRPMKEISKIIS 221
Cdd:COG1802   158 LRARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 88-207 3.19e-18

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 77.02  E-value: 3.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  88 IYETMAGLHSIIGKQALQNITDADLKLLSEINADFQRSIEKKNAKQALKLDIQFHNTISSIAKNQYIEPFLENMQLHVLR 167
Cdd:pfam07729   2 LYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1212733095 168 LEYLFFQNFVPASQSIEEHHSIIQALQKQDEKQMEQMMSQ 207
Cdd:pfam07729  82 LRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-78 1.48e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 68.63  E-value: 1.48e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212733095  19 VLNQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIA 78
Cdd:cd07377     6 IADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 19-207 3.60e-12

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 63.50  E-value: 3.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  19 VLNQLQDWIIEGVLQP-DEKINDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPIKLDDIPIIYETMA---- 93
Cdd:PRK03837   18 VEERLEQMIRSGEFGPgDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLSGMAkdfl 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  94 -----GL----------HSIIGKQALQNITDADLKLLSEINADFQRSIEkkNAKQALKLDIQFHNTISSIAKNQYIEPFL 158
Cdd:PRK03837   98 sqspdGLahlkqarlffESSLARYAAEHATDEQIALLRKALERNSQSLG--DNAAFIRSDMEFHRVIAEIPGNPIFMAIH 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1212733095 159 ENM-----QLHVLRLEYLFFQNFvpasqSIEEHHSIIQALQKQDEKQMEQMMSQ 207
Cdd:PRK03837  176 EALldwliEARPEVVILHGHENV-----TLQEHIAIVDAIRAHDPDEADRALQS 224
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-77 4.14e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 59.13  E-value: 4.14e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   19 VLNQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKI 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-221 2.04e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 176.27  E-value: 2.04e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   1 MPIPQDYKkqgRVSAKSLVLNQLQDWIIEGVLQPDEKINDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPI 80
Cdd:COG1802     1 MTSPSPLR---RESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  81 KLDDIPIIYETMAGLHSIIGKQALQNITDADLKLLSEINADFQRSIEKKNAKQALKLDIQFHNTISSIAKNQYIEPFLEN 160
Cdd:COG1802    78 SPEEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRR 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212733095 161 MQLHVLRLEYLFFQNFVPASQSIEEHHSIIQALQKQDEKQMEQMMSQNWLRPMKEISKIIS 221
Cdd:COG1802   158 LRARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
8-207 1.46e-34

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 122.73  E-value: 1.46e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   8 KKQGRVSAKSLVLNQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAP------- 79
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREpspwall 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  80 ------IKLDDIPI--IYETMAGLHSIIGKQALQNITDADLKLLSEINADFQRSIEkkNAKQALKLDIQFHNTISSIAKN 151
Cdd:COG2186    81 dplallLALDDASLrdLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAAD--DGEAFAEADLAFHRAIAEASGN 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1212733095 152 QYIEPFLENMQLHVLRLEYLFFQNFVPASQSIEEHHSIIQALQKQDEKQMEQMMSQ 207
Cdd:COG2186   159 PLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRA 214
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 88-207 3.19e-18

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 77.02  E-value: 3.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  88 IYETMAGLHSIIGKQALQNITDADLKLLSEINADFQRSIEKKNAKQALKLDIQFHNTISSIAKNQYIEPFLENMQLHVLR 167
Cdd:pfam07729   2 LYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1212733095 168 LEYLFFQNFVPASQSIEEHHSIIQALQKQDEKQMEQMMSQ 207
Cdd:pfam07729  82 LRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-78 1.48e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 68.63  E-value: 1.48e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1212733095  19 VLNQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIA 78
Cdd:cd07377     6 IADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 22-77 4.27e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 61.86  E-value: 4.27e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1212733095  22 QLQDWIIEGVLQPDEKIN-DGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKI 77
Cdd:pfam00392   8 RLREDILSGRLRPGDKLPsERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 19-207 3.60e-12

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 63.50  E-value: 3.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  19 VLNQLQDWIIEGVLQP-DEKINDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPIKLDDIPIIYETMA---- 93
Cdd:PRK03837   18 VEERLEQMIRSGEFGPgDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLSGMAkdfl 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  94 -----GL----------HSIIGKQALQNITDADLKLLSEINADFQRSIEkkNAKQALKLDIQFHNTISSIAKNQYIEPFL 158
Cdd:PRK03837   98 sqspdGLahlkqarlffESSLARYAAEHATDEQIALLRKALERNSQSLG--DNAAFIRSDMEFHRVIAEIPGNPIFMAIH 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1212733095 159 ENM-----QLHVLRLEYLFFQNFvpasqSIEEHHSIIQALQKQDEKQMEQMMSQ 207
Cdd:PRK03837  176 EALldwliEARPEVVILHGHENV-----TLQEHIAIVDAIRAHDPDEADRALQS 224
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-77 4.14e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 59.13  E-value: 4.14e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   19 VLNQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKI 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 22-223 4.65e-12

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 62.99  E-value: 4.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  22 QLQDWIIEGVLQPDEKINDGELAE--ALGVSrtPVREALQILELSGLVEMVPGQKTKIAPIKLDDIPIIYETMAGLHSII 99
Cdd:PRK11534   15 WLKNDIIRGNFQPDEKLRMSLLTSryALGVG--PLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAML 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095 100 GKQALQNITDA----------DLKLLSEINADFQRSIEKKNAKQAlkldiqFHNTISSIAKNQYIEPFLENMQLHVLRLE 169
Cdd:PRK11534   93 VSLAIARGGDEweadvlakahLLSKLEACDASEKMLDEWDLRHQA------FHTAIVAGCGSHYLLQMRERLFDLAARYR 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1212733095 170 YLFFQNFVPASQSIE----EHHSIIQALQKQDEKQMEQMMSQNWLRPMKEISKIISTK 223
Cdd:PRK11534  167 FIWLRRTVLSVEMLEdkhdQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMAGN 224
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
21-93 4.51e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 57.56  E-value: 4.51e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1212733095  21 NQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPIK----LDDIPIIYETMA 93
Cdd:COG2188    12 DALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKieypLSRLTSFTEELR 89
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 19-205 1.18e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 53.62  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  19 VLNQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKI-------------APIKL-- 82
Cdd:PRK10421    7 VADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIrwrhetwseqnivQPLKTlm 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  83 -DDIPIIYETMAGLHSIIGK---QALQNITDADlklLSEINADFQrSIEKKNAKQALKLDIQFHNTISSIAKN----QYI 154
Cdd:PRK10421   87 aDDPDYSFDILEARHAIEAStawHAAMRATPGD---KEKIQLCFE-ATLSEDPDLASQADVRFHLAIAEASHNvvllQTM 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1212733095 155 EPFLENMQLHVLRLEYLFFQNFVPASQSIEEHHSIIQALQKQDEKQMEQMM 205
Cdd:PRK10421  163 RGFFDVLQSSVKQSRQRMYLVPPVFSQLTEQHQAVMDAILAGDAEGARKAM 213
PRK11414 PRK11414
GntR family transcriptional regulator;
9-208 1.54e-08

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 52.95  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   9 KQGRVSAKSLVLNQLQDWIIEGVLQPDEKINDGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPIKLDDIPII 88
Cdd:PRK11414    6 KTQHISLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  89 YETMAGLHSIIGKQALQNITDADLKLLSEINADFQRSIEKKNAKQALKLDIQFHNTISSIAKNQYIEPFLENMQLHVLRL 168
Cdd:PRK11414   86 NRIRYELELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRMGPS 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1212733095 169 EYLFFQNFVPAS--QSIEEHHSIIQALQKQDEKQ----MEQMMSQN 208
Cdd:PRK11414  166 LHYLYEAINPAElrEHIENYRLLLAALKAKDKEGcrhcLAEIMQQN 211
PRK10225 PRK10225
Uxu operon transcriptional regulator;
23-208 6.82e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 48.48  E-value: 6.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  23 LQDWIIEGVLQPDEKIN-DGELAEALGVSRTPVREALQILELSGLVEMVPGQKTKI----APIKLDDIPIIYETMAGLHS 97
Cdd:PRK10225   18 IRDLIIKTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVldssGSHNTDSPDANVCNDAGPFE 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  98 IIGKQALQNITDADLKLLSEINADFQRsiekknAKQALKL----------------DIQFHNTISSIAKNQY-IEPFLEN 160
Cdd:PRK10225   98 LLQARQLLESNIAEFAALQATREDIVK------MRQALQLeerelassapgssesgDMQFHLAIAEATHNSMlVELFRQS 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1212733095 161 ----------MQLHVLRLEYLFFQNFvpasqsIEEHHSIIQALQKQDEKQMEQMMSQN 208
Cdd:PRK10225  172 wqwrennpmwIQLHSHLDDSLYRKEW------LGDHKQILAALIKKDARAAKLAMWQH 223
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
19-67 9.82e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 48.09  E-value: 9.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1212733095  19 VLNQLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLV 67
Cdd:PRK09464   15 IEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLL 64
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 22-72 2.06e-06

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 47.52  E-value: 2.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1212733095  22 QLQDWIIEGVLQPDEKInd-gELAEALGVSRTPVREALQILELSGLVEMVPG 72
Cdd:COG1167    20 ALREAILSGRLPPGDRLpssrELAAQLGVSRSTVVRAYEELEAEGLIESRPG 71
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 42-80 9.19e-05

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 39.43  E-value: 9.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1212733095  42 ELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPI 80
Cdd:pfam01978  27 EIAEESGVPRSKVYEVLRSLEDKGLVEREKGRPKKYRAV 65
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 8-152 1.06e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 42.06  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095   8 KKQGRVSAKSLVLNQLQDWIIEGVLQ-----PDEKindgELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPI-- 80
Cdd:PRK09990    1 MKDERRPIADVVAERIERLIVDGVLKvgqalPSER----RLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLnr 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  81 KLDDIPIIY-------------ETMAGLHSIIGKQALQNITDADLKLLS----EINADFQRSIEKKNAKQAlKLDIQFHN 143
Cdd:PRK09990   77 VQDASPLMHlfssqprtlydllEVRALLEGESARLAALRGTQADFVLITrryeEMLAAHENNKEIDPIEHA-RLDHAFHL 155


                  ....*....
gi 1212733095 144 TISSIAKNQ 152
Cdd:PRK09990  156 AICEASHNP 164
PRK11523 PRK11523
transcriptional regulator ExuR;
22-207 7.11e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 39.44  E-value: 7.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  22 QLQDWIIEGVLQPDEKI-NDGELAEALGVSRTPVREALQILELSGLVEMVPG---------QKTKIAPIKLDDIPII--Y 89
Cdd:PRK11523   16 ELKERIEQGVYLVGDKLpAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGsgihvvsnqPRHQQAADNNMEFANYgpF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212733095  90 ETMAG---LHSIIGKQALQNITDADLKLLSEInadfQRSIEKKNAKQALKLDIQFHNTISSIAKNQYIEPFLENMQLHVL 166
Cdd:PRK11523   96 ELLQArqlIESNIAEFAATQVTKQDIMKLMAI----QEQARGEDCFRDSEWDLQFHVQVALATQNSALAAIVEKMWTQRS 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1212733095 167 RLEYLFFQNFVPASQSI----EEHHSIIQALQKQDEKQMEQMMSQ 207
Cdd:PRK11523  172 HNPYWKKLHEHIDDRTVdnwcDDHDQILKALIRKDPHAAKLAMWQ 216
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 41-77 1.29e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1212733095  41 GELAEALGVSRTPVREALQILELSGLVEMVPGQKTKI 77
Cdd:cd00090    24 SELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVY 60
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 27-82 1.76e-03

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 36.72  E-value: 1.76e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1212733095   27 IIEgVLQPDEKINDGELAEALGVSRTPVREALQILELSGLVEmvpGQKTKIAPIKL 82
Cdd:smart00344   8 ILE-ELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIK---GYTAVLNPKKL 59
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
42-85 3.97e-03

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 37.31  E-value: 3.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1212733095  42 ELAEALGVSRTPVREALQILELSGLVEMVPGQKTKIAPIKLDDI 85
Cdd:COG1378    32 ELAKASGVPRSRVYDVLESLEEKGLVEVSEGRPKRYRAVPPEEA 75
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 27-73 8.37e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 33.56  E-value: 8.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1212733095  27 IIEGVLQPDEKINDGELAEALGVSRTPVREALQILELSGL-VEMVPGQ 73
Cdd:pfam08279   3 ILQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGVpIEAEPGR 50
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
41-68 9.66e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.05  E-value: 9.66e-03
                          10        20
                  ....*....|....*....|....*...
gi 1212733095  41 GELAEALGVSRTPVREALQILELSGLVE 68
Cdd:COG2345    31 AELAEALGLTPNAVRRHLDALEEEGLVE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH