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Conserved domains on  [gi|1215900003|ref|WP_089084663|]
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type VI secretion system baseplate subunit TssE [Aquitalea magnusonii]

Protein Classification

type VI secretion system baseplate subunit TssE( domain architecture ID 10007507)

type VI secretion system (T6SS) baseplate subunit TssE is a component of the T6SS baseplate that serves not only as the tail assembly platform, but also docks the tail to the membrane complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3518 COG3518
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 9-134 1.13e-23

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442740  Cd Length: 162  Bit Score: 90.81  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215900003   9 GASLYEKLLGNFQD---GSSLHAWDENSQHLFSVMDNIRVILNSRQGAI----------KHLPDYGLPDLALIYRHLPAS 75
Cdd:COG3518    11 QPSLLDRLTDDEPDrsrESPLSRVVSLEQLRESVRRDLEWLLNTRRGEAsllaaypevrRSVLNYGLPDLSGASLGSPDD 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1215900003  76 AHLLRQHIASTLLRYEPRLAHIDIQLLA--NAQHDVLGYELVCHLKQSG---LVRFGSYFTPDH 134
Cdd:COG3518    91 REAIERAIRQAILRFEPRLRRVSVTVLPddDDSPNTLRFRIEAVLWADPapePVRFDTVLDLET 154
 
Name Accession Description Interval E-value
COG3518 COG3518
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 9-134 1.13e-23

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442740  Cd Length: 162  Bit Score: 90.81  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215900003   9 GASLYEKLLGNFQD---GSSLHAWDENSQHLFSVMDNIRVILNSRQGAI----------KHLPDYGLPDLALIYRHLPAS 75
Cdd:COG3518    11 QPSLLDRLTDDEPDrsrESPLSRVVSLEQLRESVRRDLEWLLNTRRGEAsllaaypevrRSVLNYGLPDLSGASLGSPDD 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1215900003  76 AHLLRQHIASTLLRYEPRLAHIDIQLLA--NAQHDVLGYELVCHLKQSG---LVRFGSYFTPDH 134
Cdd:COG3518    91 REAIERAIRQAILRFEPRLRRVSVTVLPddDDSPNTLRFRIEAVLWADPapePVRFDTVLDLET 154
VI_zyme TIGR03357
type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 ...
 9-138 9.26e-23

type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 cites acidic lysozyme activity for some phage-encoded members. This family represents a different subgroup of the proteins from pfam04965, where all members are associated with bacterial type VI secretion system genomic contexts.


Pssm-ID: 274540  Cd Length: 133  Bit Score: 87.66  E-value: 9.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215900003   9 GASLYEKLlGNFQDGSSLHAWDENSQHLFSVMDNIRVILNSRQGAIKHLPDYGLPDLALIYRHLPASAHLLRQHIASTLL 88
Cdd:TIGR03357   1 TPSLFERL-PDASGESPSTRRSSAEQLRESIRRHLERLLNTRRGSCASLPDYGLPDLNDLSLSSADDRRRIRRAIEQAIE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1215900003  89 RYEPRLAHIDIQLLANAQHD-VLGYELVCHLKQSG---LVRFGSYFTPDHAVRL 138
Cdd:TIGR03357  80 RYEPRLSRVRVTALPDEEDPlALRFRIEAELDVDGgpePVSFDALLDPSGRYRV 133
GPW_gp25 pfam04965
Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like ...
 38-108 5.21e-12

Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like proteins, found in several systems, including contractile tail bacteriophages, the type VI secretion system (T6SS) and R-type pyocins, which constitute a multiprotein tubular apparatus to attach to and penetrate host cell membranes. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerization, playing a critical role in sheath assembly and contraction. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD). This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems.


Pssm-ID: 428225  Cd Length: 93  Bit Score: 58.75  E-value: 5.21e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1215900003  38 SVMDNIRVILNSRQGAIKHLPDYGLPDLALIYRHL-PASAHLLRQHIASTLLRYEPRLAHIDIQLLANAQHD 108
Cdd:pfam04965   6 SVRRDLEILLNTRPGERVSRPNYGCPDLALLFAPNdDATRALIERAIREAILRFEPRIRVVSVEVDPDPDSP 77
 
Name Accession Description Interval E-value
COG3518 COG3518
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 9-134 1.13e-23

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442740  Cd Length: 162  Bit Score: 90.81  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215900003   9 GASLYEKLLGNFQD---GSSLHAWDENSQHLFSVMDNIRVILNSRQGAI----------KHLPDYGLPDLALIYRHLPAS 75
Cdd:COG3518    11 QPSLLDRLTDDEPDrsrESPLSRVVSLEQLRESVRRDLEWLLNTRRGEAsllaaypevrRSVLNYGLPDLSGASLGSPDD 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1215900003  76 AHLLRQHIASTLLRYEPRLAHIDIQLLA--NAQHDVLGYELVCHLKQSG---LVRFGSYFTPDH 134
Cdd:COG3518    91 REAIERAIRQAILRFEPRLRRVSVTVLPddDDSPNTLRFRIEAVLWADPapePVRFDTVLDLET 154
VI_zyme TIGR03357
type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 ...
 9-138 9.26e-23

type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 cites acidic lysozyme activity for some phage-encoded members. This family represents a different subgroup of the proteins from pfam04965, where all members are associated with bacterial type VI secretion system genomic contexts.


Pssm-ID: 274540  Cd Length: 133  Bit Score: 87.66  E-value: 9.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215900003   9 GASLYEKLlGNFQDGSSLHAWDENSQHLFSVMDNIRVILNSRQGAIKHLPDYGLPDLALIYRHLPASAHLLRQHIASTLL 88
Cdd:TIGR03357   1 TPSLFERL-PDASGESPSTRRSSAEQLRESIRRHLERLLNTRRGSCASLPDYGLPDLNDLSLSSADDRRRIRRAIEQAIE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1215900003  89 RYEPRLAHIDIQLLANAQHD-VLGYELVCHLKQSG---LVRFGSYFTPDHAVRL 138
Cdd:TIGR03357  80 RYEPRLSRVRVTALPDEEDPlALRFRIEAELDVDGgpePVSFDALLDPSGRYRV 133
GPW_gp25 pfam04965
Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like ...
 38-108 5.21e-12

Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like proteins, found in several systems, including contractile tail bacteriophages, the type VI secretion system (T6SS) and R-type pyocins, which constitute a multiprotein tubular apparatus to attach to and penetrate host cell membranes. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerization, playing a critical role in sheath assembly and contraction. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD). This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems.


Pssm-ID: 428225  Cd Length: 93  Bit Score: 58.75  E-value: 5.21e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1215900003  38 SVMDNIRVILNSRQGAIKHLPDYGLPDLALIYRHL-PASAHLLRQHIASTLLRYEPRLAHIDIQLLANAQHD 108
Cdd:pfam04965   6 SVRRDLEILLNTRPGERVSRPNYGCPDLALLFAPNdDATRALIERAIREAILRFEPRIRVVSVEVDPDPDSP 77
COG3628 COG3628
Phage baseplate assembly protein W [Mobilome: prophages, transposons];
43-108 4.42e-05

Phage baseplate assembly protein W [Mobilome: prophages, transposons];


Pssm-ID: 442846  Cd Length: 119  Bit Score: 40.62  E-value: 4.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1215900003  43 IRVILNSRQGAIKHLPDYG--LPDLalIYRHL-PASAHLLRQHIASTLLRYEPRLAHIDIQLLANAQHD 108
Cdd:COG3628    26 IRIILTTPPGERVMRPDFGsgLHDL--LFEPNnPATALLIRAAVAEALLRWEPRIEVESVDVTPDPEED 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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