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Conserved domains on  [gi|1221640628|ref|WP_089769531|]
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phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating) [Halobellus clavatus]

Protein Classification

decarboxylating 6-phosphogluconate dehydrogenase( domain architecture ID 11484385)

NADP-dependent decarboxylating 6-phosphogluconate dehydrogenase (6-PGDH) catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH

CATH:  3.40.50.720
EC:  1.1.1.-
Gene Ontology:  GO:0004616|GO:0050661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
1-299 1.58e-158

NADP-dependent phosphogluconate dehydrogenase;


:

Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 443.81  E-value: 1.58e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGEAVDATLEEL 80
Cdd:PRK09599    1 MQLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEITDATIDEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  81 DPHLAADDVVVDGGNSHFEASVRRAE---STDAAYLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVATG-PAGH 156
Cdd:PRK09599   81 APLLSPGDIVIDGGNSYYKDDIRRAEllaEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRaEDGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 157 DRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGRYDLDLESVARTWNNGAVIRSWLLELCEEAFREEGnDLGDVAD 236
Cdd:PRK09599  161 LHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASRFDLDLAAVAEVWRRGSVIRSWLLDLTADALAEDP-KLDEISG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1221640628 237 HVAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSRADDgRFARRLANRLRYGFGRHDVKRRG 299
Cdd:PRK09599  240 YVEDSGEGRWTVEEAIDLAVPAPVIAAALFMRFRSRQED-SFADKVVAALRNGFGGHAVKKKE 301
 
Name Accession Description Interval E-value
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
1-299 1.58e-158

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 443.81  E-value: 1.58e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGEAVDATLEEL 80
Cdd:PRK09599    1 MQLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEITDATIDEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  81 DPHLAADDVVVDGGNSHFEASVRRAE---STDAAYLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVATG-PAGH 156
Cdd:PRK09599   81 APLLSPGDIVIDGGNSYYKDDIRRAEllaEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRaEDGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 157 DRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGRYDLDLESVARTWNNGAVIRSWLLELCEEAFREEGnDLGDVAD 236
Cdd:PRK09599  161 LHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASRFDLDLAAVAEVWRRGSVIRSWLLDLTADALAEDP-KLDEISG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1221640628 237 HVAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSRADDgRFARRLANRLRYGFGRHDVKRRG 299
Cdd:PRK09599  240 YVEDSGEGRWTVEEAIDLAVPAPVIAAALFMRFRSRQED-SFADKVVAALRNGFGGHAVKKKE 301
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
1-297 1.03e-132

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 378.28  E-value: 1.03e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGEAVDATLEEL 80
Cdd:COG1023     1 MQIGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAALAAEGATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  81 DPHLAADDVVVDGGNSHFEASVRRAESTDAA---YLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVATGPA-GH 156
Cdd:COG1023    81 APLLEPGDIVIDGGNSNYKDDIRRAEELAEKgihFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAEnGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 157 DRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGRYDLDLESVARTWNNGAVIRSWLLELCEEAFREEGnDLGDVAD 236
Cdd:COG1023   161 LHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASEFDLDLAEVAEVWRRGSVIRSWLLDLTADALAEDP-KLEGISG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1221640628 237 HVAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSRaDDGRFARRLANRLRYGFGRHDVKR 297
Cdd:COG1023   240 YVEDSGEGRWTVEEAIELGVPAPVITAALFARFRSR-QEDSFADKVLAALRNQFGGHAVKK 299
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 1-298 1.26e-90

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 271.72  E-value: 1.26e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGeAVDATLEEL 80
Cdd:TIGR00872   1 MQLGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVKAMKEDRTTGVANLRELSQRLSAPRVVWVMVPHG-IVDAVLEEL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  81 DPHLAADDVVVDGGNSHFEASVRRAE---STDAAYLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVATGPAGHD 157
Cdd:TIGR00872  80 APTLEKGDIVIDGGNSYYKDSLRRYKllkEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPEEQGYL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 158 RMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGRYDLDLESVARTWNNGAVIRSWLLELCEEAFREEGnDLGDVADH 237
Cdd:TIGR00872 160 YCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSQFDFDIPEVARVWRRGSVIRSWLLDLTAIAFRESP-DLAEFSGR 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1221640628 238 VAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSRADDgRFARRLANRLRYGFGRHDVKRR 298
Cdd:TIGR00872 239 VSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFASRDLD-DFANKVLAALRKEFGGHAEKKK 298
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 2-150 1.31e-33

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 120.65  E-value: 1.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   2 QLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLgeeKRIWLMVPAGEAVDATLEE-- 79
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGAIAAASPAEFVAGL---DVVITMVPAGAAVDAVIFGeg 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1221640628  80 LDPHLAADDVVVDGGNSHFEASVRRAE---STDAAYLDCGTSGGPAGAERG-FSLMIGGPEWAYEALTPVFDAVA 150
Cdd:pfam03446  78 LLPGLKPGDIIIDGSTSSPEDARRRAKelkEKGLHFLDAPVSGGEAGAENGtLSIMVGGDEEAFERVKPILEAMG 152
 
Name Accession Description Interval E-value
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
1-299 1.58e-158

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 443.81  E-value: 1.58e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGEAVDATLEEL 80
Cdd:PRK09599    1 MQLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEITDATIDEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  81 DPHLAADDVVVDGGNSHFEASVRRAE---STDAAYLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVATG-PAGH 156
Cdd:PRK09599   81 APLLSPGDIVIDGGNSYYKDDIRRAEllaEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRaEDGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 157 DRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGRYDLDLESVARTWNNGAVIRSWLLELCEEAFREEGnDLGDVAD 236
Cdd:PRK09599  161 LHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASRFDLDLAAVAEVWRRGSVIRSWLLDLTADALAEDP-KLDEISG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1221640628 237 HVAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSRADDgRFARRLANRLRYGFGRHDVKRRG 299
Cdd:PRK09599  240 YVEDSGEGRWTVEEAIDLAVPAPVIAAALFMRFRSRQED-SFADKVVAALRNGFGGHAVKKKE 301
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
1-297 1.03e-132

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 378.28  E-value: 1.03e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGEAVDATLEEL 80
Cdd:COG1023     1 MQIGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAALAAEGATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  81 DPHLAADDVVVDGGNSHFEASVRRAESTDAA---YLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVATGPA-GH 156
Cdd:COG1023    81 APLLEPGDIVIDGGNSNYKDDIRRAEELAEKgihFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAEnGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 157 DRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGRYDLDLESVARTWNNGAVIRSWLLELCEEAFREEGnDLGDVAD 236
Cdd:COG1023   161 LHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASEFDLDLAEVAEVWRRGSVIRSWLLDLTADALAEDP-KLEGISG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1221640628 237 HVAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSRaDDGRFARRLANRLRYGFGRHDVKR 297
Cdd:COG1023   240 YVEDSGEGRWTVEEAIELGVPAPVITAALFARFRSR-QEDSFADKVLAALRNQFGGHAVKK 299
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 1-298 1.26e-90

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 271.72  E-value: 1.26e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGeAVDATLEEL 80
Cdd:TIGR00872   1 MQLGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVKAMKEDRTTGVANLRELSQRLSAPRVVWVMVPHG-IVDAVLEEL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  81 DPHLAADDVVVDGGNSHFEASVRRAE---STDAAYLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVATGPAGHD 157
Cdd:TIGR00872  80 APTLEKGDIVIDGGNSYYKDSLRRYKllkEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPEEQGYL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 158 RMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGRYDLDLESVARTWNNGAVIRSWLLELCEEAFREEGnDLGDVADH 237
Cdd:TIGR00872 160 YCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSQFDFDIPEVARVWRRGSVIRSWLLDLTAIAFRESP-DLAEFSGR 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1221640628 238 VAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSRADDgRFARRLANRLRYGFGRHDVKRR 298
Cdd:TIGR00872 239 VSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFASRDLD-DFANKVLAALRKEFGGHAEKKK 298
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-269 1.15e-64

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 209.93  E-value: 1.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPA-----EDLADLTDRLGEEKRIWLMVPAGEAVDA 75
Cdd:COG0362     3 ADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKnivgtYSLEEFVASLERPRKILLMVKAGKPVDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  76 TLEELDPHLAADDVVVDGGNSHFEASVRRAESTDAA---YLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVAtg 152
Cdd:COG0362    83 VIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKgihFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA-- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 153 pAGHD------RMGASGSGHYVKMVHNGVEYALMQAYGEGFELL--ANGRYDLDLESVARTWNNGaVIRSWLLELCEEAF 224
Cdd:COG0362   161 -AKVDgepcvtYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLrdGLGLSNDEIAEVFAEWNKG-ELDSYLIEITADIL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1221640628 225 R----EEGNDLGDVADHVAG--GsTGTWTVQEALEQEVPVPLIYQALAERF 269
Cdd:COG0362   239 RkkdpETGKPLVDVILDKAGqkG-TGKWTSQSALDLGVPLPLITEAVFARY 288
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
48-279 7.65e-61

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 199.97  E-value: 7.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  48 EDLADLTDRLGEEKRIWLMVPAGEAVDATLEELDPHLAADDVVVDGGNSHFEASVRRA---ESTDAAYLDCGTSGGPAGA 124
Cdd:PRK09287   43 YTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLEKGDIIIDGGNSNYKDTIRREkelAEKGIHFIGMGVSGGEEGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 125 ERGFSLMIGGPEWAYEALTPVFDAVA----TGPAGHDRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGrYDLDLE 200
Cdd:PRK09287  123 LHGPSIMPGGQKEAYELVAPILEKIAakveDGEPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDG-LGLSAE 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 201 SVA---RTWNNGaVIRSWLLELCEEAFR----EEGNDLGDVADHVAG--GsTGTWTVQEALEQEVPVPLIYQALAERFGS 271
Cdd:PRK09287  202 EIAdvfAEWNKG-ELNSYLIEITADILRqkdeETGKPLVDVILDKAGqkG-TGKWTSQSALDLGVPLTLITEAVFARYLS 279


                  ....*...
gi 1221640628 272 RADDGRFA 279
Cdd:PRK09287  280 SLKDQRVA 287
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 2-279 1.54e-60

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 199.55  E-value: 1.54e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   2 QLGVVGLGRMGQIVVDRVIDAGHDVVAFD-----LDAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGEAVDAT 76
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNrtpskTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  77 LEELDPHLAADDVVVDGGNSHFEASVRRAESTDAA---YLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVAT-- 151
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKgilFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAkv 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 152 -GPAGHDRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLANGrYDLDLESVART---WNNGaVIRSWLLELCEEAFR-- 225
Cdd:TIGR00873 161 dGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRG-LGLSNEEIAEIfteWNNG-ELDSYLIEITADILAkk 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1221640628 226 -EEGNDLGDVADHVAGGS-TGTWTVQEALEQEVPVPLIYQALAERFGSRADDGRFA 279
Cdd:TIGR00873 239 dEDGNPLVDKILDTAGQKgTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVA 294
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 3-268 5.12e-52

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 177.29  E-value: 5.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   3 LGVVGLGRMGQIVVDRVIDAGHDVVAFDL------DAEAVATAADAGATPAEDLADLTDRLGEEKRIWLMVPAGEAVDAT 76
Cdd:PTZ00142    4 IGLIGLAVMGQNLALNIASRGFKISVYNRtyekteEFVKKAKEGNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAVDET 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  77 LEELDPHLAADDVVVDGGNSHFEASVRR---AESTDAAYLDCGTSGGPAGAERGFSLMIGGPEWAYEALTPVFDAVAT-- 151
Cdd:PTZ00142   84 IDNLLPLLEKGDIIIDGGNEWYLNTERRikrCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCSAkv 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 152 -GPAGHDRMGASGSGHYVKMVHNGVEYALMQAYGEGFELL--ANGRYDLDLESVARTWNNGaVIRSWLLELCEEAFREEg 228
Cdd:PTZ00142  164 gDSPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMkhILGMSNEELSEVFNKWNEG-ILNSYLIEITAKILAKK- 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1221640628 229 NDLGD------VADHVAGGSTGTWTVQEALEQEVPVPLIYQALAER 268
Cdd:PTZ00142  242 DDLGEehlvdkILDIAGSKGTGKWTVQEALERGIPVPTMAASVDAR 287
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 48-279 8.31e-41

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 147.94  E-value: 8.31e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  48 EDLADLTDRLGEEKRIWLMVPAGEAVDATLEELDPHLAADDVVVDGGNSHFEASVRRAESTDAA---YLDCGTSGGPAGA 124
Cdd:PLN02350   61 KDPEDFVLSIQKPRSVIILVKAGAPVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKgllYLGMGVSGGEEGA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 125 ERGFSLMIGGPEWAYEALTPVFDAVA----TGPAGhDRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLAN--GRYDLD 198
Cdd:PLN02350  141 RNGPSLMPGGSFEAYKNIEDILEKVAaqvdDGPCV-TYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSvgGLSNEE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 199 LESVARTWNNGAvIRSWLLELCEEAFREEgNDLGD------VADHVAGGSTGTWTVQEALEQEVPVPLIYQALAERFGSR 272
Cdd:PLN02350  220 LAEVFAEWNKGE-LESFLIEITADIFSVK-DDKGDgylvdkILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSG 297


                  ....*..
gi 1221640628 273 ADDGRFA 279
Cdd:PLN02350  298 LKEERVA 304
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 2-150 1.31e-33

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 120.65  E-value: 1.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   2 QLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLgeeKRIWLMVPAGEAVDATLEE-- 79
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGAIAAASPAEFVAGL---DVVITMVPAGAAVDAVIFGeg 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1221640628  80 LDPHLAADDVVVDGGNSHFEASVRRAE---STDAAYLDCGTSGGPAGAERG-FSLMIGGPEWAYEALTPVFDAVA 150
Cdd:pfam03446  78 LLPGLKPGDIIIDGSTSSPEDARRRAKelkEKGLHFLDAPVSGGEAGAENGtLSIMVGGDEEAFERVKPILEAMG 152
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 1-282 2.42e-30

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 115.60  E-value: 2.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADLTDRLGeekRIWLMVPAGEAVDATL--- 77
Cdd:COG2084     2 MKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAAGARVAASPAEAAAAAD---VVITMLPDDAAVEEVLlge 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  78 EELDPHLAADDVVVDGGNSHFEASVR---RAESTDAAYLDCGTSGGPAGAERG-FSLMIGGPEWAYEALTPVFDAVAtgp 153
Cdd:COG2084    79 DGLLAALRPGAVVVDMSTISPETARElaaAAAARGVRYLDAPVSGGPAGAEAGtLTIMVGGDEAAFERARPVLEAMG--- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 154 AGHDRMGASGSGHYVKMVHNGVEYALMQAYGEGFELLAngRYDLDLESVARTWNNGAViRSWLLELCEEAFREEgndlgd 233
Cdd:COG2084   156 KRIVHVGDAGAGQAAKLANNLLLAGTMAALAEALALAE--KAGLDPETLLEVLSGGAA-GSWVLENRGPRMLAG------ 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1221640628 234 vaDHVAGGSTGTWT------VQEALEQEVPVPL------IYQALAERFGSRADDGRFARRL 282
Cdd:COG2084   227 --DFDPGFALDLMLkdlglaLEAARAAGVPLPLaaaarqLYARAVAAGHGDEDFSALIKLL 285
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 165-271 5.93e-25

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 100.99  E-value: 5.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 165 GHYVKMVHNGVEYALMQAYGEGFELLANGrYDLDLESVART---WNNGaVIRSWLLELCEEAFRE-EGNDLGDVADHV-- 238
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRG-LGLSNDEIADVfeeWNKG-ELDSYLIEITADILRKkDPEDGKPLVDKIld 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1221640628 239 AGGS--TGTWTVQEALEQEVPVPLIYQALAERFGS 271
Cdd:pfam00393  79 KAGQkgTGKWTVQEALDLGVPAPTIAEAVFARCLS 113
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 182-266 7.86e-08

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 52.46  E-value: 7.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628 182 AYGEGFELLANGR----YDLDLESVARTWNNGAVIRSWLLELCEEAFREEGND---------LGDVADHVAGgstgtW-- 246
Cdd:pfam00393 156 SYAQGFALLRAASkeygWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLsnllldpyfAKELKEAQPS-----Wrr 230

                          90       100
                  ....*....|....*....|
gi 1221640628 247 TVQEALEQEVPVPLIYQALA 266
Cdd:pfam00393 231 VVALAVEAGIPVPALSAALS 250
garR PRK11559
tartronate semialdehyde reductase; Provisional
 1-199 9.68e-07

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 49.28  E-value: 9.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHDVVAFDLDAEAVATAADAGATPAEDLADltdrLGEEKRIWL-MVPAGEAVDATLee 79
Cdd:PRK11559    3 MKVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETASTAKA----VAEQCDVIItMLPNSPHVKEVA-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  80 LDPH-----LAADDVVVDGGNSHFEASVRRAESTDA---AYLDCGTSGGPAGAERG-FSLMIGGPEWAYEALTPVFDAVA 150
Cdd:PRK11559   77 LGENgiiegAKPGTVVIDMSSIAPLASREIAAALKAkgiEMLDAPVSGGEPKAIDGtLSVMVGGDKAIFDKYYDLMKAMA 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1221640628 151 TGPAghdRMGASGSGHYVKMVhNGVEYAL-MQAYGEGFELLANGRYDLDL 199
Cdd:PRK11559  157 GSVV---HTGDIGAGNVTKLA-NQVIVALnIAAMSEALVLATKAGVNPDL 202
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
1-179 1.11e-05

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 46.17  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628   1 MQLGVVGLGRMGQIVVDRVIDAGHD--VVAFDLDAEAVATAADAGATPAEDLADLTDrlgeekRIWLMVPAGEAVDATLe 78
Cdd:PRK15059    1 MKLGFIGLGIMGTPMAINLARAGHQlhVTTIGPVADELLSLGAVSVETARQVTEASD------IIFIMVPDTPQVEEVL- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221640628  79 eLDPHLAAD-----DVVVDGGN-SHFEAS--VRRAESTDAAYLDCGTSGGPAGAERG-FSLMIGGPEWAYEALTPVFDAV 149
Cdd:PRK15059   74 -FGENGCTKaslkgKTIVDMSSiSPIETKrfARQVNELGGDYLDAPVSGGEIGAREGtLSIMVGGDEAVFERVKPLFELL 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 1221640628 150 ATGPAghdRMGASGSGHYVKmVHNGVEYAL 179
Cdd:PRK15059  153 GKNIT---LVGGNGDGQTCK-VANQIIVAL 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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