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Conserved domains on  [gi|1222325168|ref|WP_090378192|]
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CDP-alcohol phosphatidyltransferase family protein [Dyadobacter sp. SG02]

Protein Classification

CDP-alcohol phosphatidyltransferase family protein( domain architecture ID 10001704)

CDP-alcohol phosphatidyltransferase family protein catalyzes the transfer of a substituted phosphate group from a cytidine-5'-diphosphate-linked donor to an alcohol acceptor, an essential reaction in the biosynthesis of phospholipids

CATH:  1.20.120.1760
EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0008654|GO:0016020|GO:0000287
PubMed:  24923293|24573438|21259003|24942835
SCOP:  3002413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 56-147 6.39e-11

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 60.26  E-value: 6.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  56 PNPVTIISIFFGVAAGILFYPQQLWInvIGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAgDFWFI-AIHIALCL 134
Cdd:COG0558    12 PNQLTLLRILLVPVFALLLLLGGALL--LALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVA-DKLLDaAALLGLVL 88

                          90
                  ....*....|...
gi 1222325168 135 RSMEEGWSAWIWV 147
Cdd:COG0558    89 LGLLPAWLALLIL 101
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 56-147 6.39e-11

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 60.26  E-value: 6.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  56 PNPVTIISIFFGVAAGILFYPQQLWInvIGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAgDFWFI-AIHIALCL 134
Cdd:COG0558    12 PNQLTLLRILLVPVFALLLLLGGALL--LALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVA-DKLLDaAALLGLVL 88

                          90
                  ....*....|...
gi 1222325168 135 RSMEEGWSAWIWV 147
Cdd:COG0558    89 LGLLPAWLALLIL 101
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 56-152 1.98e-04

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 41.00  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  56 PNPVTIISIFFGVA-AGILFYPQQLWInviGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAgDFwfiaIHIALCL 134
Cdd:pfam01066   4 PNLLTLLRILLVPVfVVLLLGPGNRIL---AAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLA-DK----LLVAAAL 75

                          90
                  ....*....|....*...
gi 1222325168 135 RSMEEGWSAWIWVPGVVA 152
Cdd:pfam01066  76 IALSILGLLPWWFVVVIL 93
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
61-165 3.09e-03

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 37.91  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  61 IISIFFGVAAgilFYPQQLWINVIGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAGDfwfIAIHIALCLRSmEEG 140
Cdd:PRK10832   14 VILIPFFVLV---FYLPFTWAPFVCALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADK---VMVAIAMVLVT-EHY 86

                          90       100
                  ....*....|....*....|....*
gi 1222325168 141 WSAWIWVPGVVAGASHMIQSAMADY 165
Cdd:PRK10832   87 HSWWVTLPAATMIAREIIISALREW 111
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 56-147 6.39e-11

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 60.26  E-value: 6.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  56 PNPVTIISIFFGVAAGILFYPQQLWInvIGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAgDFWFI-AIHIALCL 134
Cdd:COG0558    12 PNQLTLLRILLVPVFALLLLLGGALL--LALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVA-DKLLDaAALLGLVL 88

                          90
                  ....*....|...
gi 1222325168 135 RSMEEGWSAWIWV 147
Cdd:COG0558    89 LGLLPAWLALLIL 101
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
56-123 1.17e-04

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 42.88  E-value: 1.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1222325168  56 PNPVTIISIFFGVAAgILFYPQQLWinVIGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAgDF 123
Cdd:COG1183    13 PNLFTLLNLFCGFLA-IVAAIEGDF--ELAALLILLAAVFDGLDGRVARLLNVQSEFGAELDSLA-DM 76
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 56-152 1.98e-04

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 41.00  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  56 PNPVTIISIFFGVA-AGILFYPQQLWInviGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAgDFwfiaIHIALCL 134
Cdd:pfam01066   4 PNLLTLLRILLVPVfVVLLLGPGNRIL---AAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLA-DK----LLVAAAL 75

                          90
                  ....*....|....*...
gi 1222325168 135 RSMEEGWSAWIWVPGVVA 152
Cdd:pfam01066  76 IALSILGLLPWWFVVVIL 93
EPT1 COG5050
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and ...
 36-117 2.23e-03

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and metabolism];


Pssm-ID: 444050  Cd Length: 176  Bit Score: 38.13  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  36 WFYRPigyqialFCAKV--GLRPNPVTII------SIFFGVAAGILFYPQQLWINVIGMLSLMFAnslDSADGQLARMTN 107
Cdd:COG5050    23 YFLRW-------LAARLpaWVTPNLLTASgalgalAIFVGYLASNGDTGAYLWLAPVGLIVYWFG---DSLDGSLARRTG 92

                          90
                  ....*....|
gi 1222325168 108 DKSRFGRILD 117
Cdd:COG5050    93 ISRPYGEFLD 102
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
61-165 3.09e-03

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 37.91  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222325168  61 IISIFFGVAAgilFYPQQLWINVIGMLSLMFANSLDSADGQLARMTNDKSRFGRILDGVAGDfwfIAIHIALCLRSmEEG 140
Cdd:PRK10832   14 VILIPFFVLV---FYLPFTWAPFVCALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADK---VMVAIAMVLVT-EHY 86

                          90       100
                  ....*....|....*....|....*
gi 1222325168 141 WSAWIWVPGVVAGASHMIQSAMADY 165
Cdd:PRK10832   87 HSWWVTLPAATMIAREIIISALREW 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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