type VI secretion system membrane subunit TssM is the IcmF (intracellular multiplication protein F) family protein that exhibits ATPase activity and energizes type VI secretion; it is a conserved T6SS inner membrane protein
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
34-1177
0e+00
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]
The actual alignment was detected with superfamily member TIGR03348:
Pssm-ID: 274531 [Multi-domain] Cd Length: 1169 Bit Score: 1089.30 E-value: 0e+00
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
34-1177
0e+00
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]
Pssm-ID: 274531 [Multi-domain] Cd Length: 1169 Bit Score: 1089.30 E-value: 0e+00
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
199-453
3.37e-89
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.
Pssm-ID: 433873 [Multi-domain] Cd Length: 258 Bit Score: 287.97 E-value: 3.37e-89
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
135-320
1.44e-04
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.
Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 43.60 E-value: 1.44e-04
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
34-1177
0e+00
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]
Pssm-ID: 274531 [Multi-domain] Cd Length: 1169 Bit Score: 1089.30 E-value: 0e+00
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
199-453
3.37e-89
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.
Pssm-ID: 433873 [Multi-domain] Cd Length: 258 Bit Score: 287.97 E-value: 3.37e-89
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
502-793
8.57e-77
Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.
Pssm-ID: 429106 [Multi-domain] Cd Length: 305 Bit Score: 255.73 E-value: 8.57e-77
Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region ...
1054-1160
1.34e-27
Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganization that results in increased adherence to epithelial cells leading to an increased conjugation frequency. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear.
Pssm-ID: 429094 [Multi-domain] Cd Length: 106 Bit Score: 107.80 E-value: 1.34e-27
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
135-320
1.44e-04
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.
Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 43.60 E-value: 1.44e-04
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
136-324
2.70e-03
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.
Pssm-ID: 206646 [Multi-domain] Cd Length: 161 Bit Score: 39.92 E-value: 2.70e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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