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Conserved domains on  [gi|1222382242|ref|WP_090434450|]
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MFS transporter [Ectopseudomonas guguanensis]

Protein Classification

MFS transporter( domain architecture ID 11457990)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0005886|GO:0016020|GO:0022857|GO:0055085
PubMed:  26098515|9529885|26758938|23403214
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-337 9.86e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   2 TREWRLGVTGFGLIAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASI 81
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  82 AMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGA--EWR 159
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlfGWR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 160 LAYGVFAAAACVLAVLAILHVPRT---AAPPVQAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAG 236
Cdd:COG2814   165 WVFLVNAVLALLALLLLLRLLPESrpaARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 237 AGLLWVVIGAAGIAGAGAG-ALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAA 315
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAgRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                         330       340
                  ....*....|....*....|...
gi 1222382242 316 LS-ERPATGLTIAFLGIAVGQTL 337
Cdd:COG2814   325 APpEARGRASGLYNSAFFLGGPL 347
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-337 9.86e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   2 TREWRLGVTGFGLIAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASI 81
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  82 AMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGA--EWR 159
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlfGWR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 160 LAYGVFAAAACVLAVLAILHVPRT---AAPPVQAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAG 236
Cdd:COG2814   165 WVFLVNAVLALLALLLLLRLLPESrpaARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 237 AGLLWVVIGAAGIAGAGAG-ALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAA 315
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAgRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                         330       340
                  ....*....|....*....|...
gi 1222382242 316 LS-ERPATGLTIAFLGIAVGQTL 337
Cdd:COG2814   325 APpEARGRASGLYNSAFFLGGPL 347
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 15-347 8.82e-11

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 62.71  E-value: 8.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  15 IAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPS 94
Cdd:cd06180     7 LAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  95 AFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSG---PVALMFGAEWRLAYGVFAAAACV 171
Cdd:cd06180    87 FAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGllvPAGLGGGLSWRAGWLALALLSAV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 172 LAVLAILHVPRTAAPPVQAHAGAALFSATLK--RLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVVIGAAGI 249
Cdd:cd06180   167 LLLLSFLLLRRGPSAPTEASAAESAPGLNRPlwRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 250 AGAGAGALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAALSERPATGLTIAFL 329
Cdd:cd06180   247 SCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMTA 326

                         330
                  ....*....|....*...
gi 1222382242 330 GIAVGQTLGAPVFGALAS 347
Cdd:cd06180   327 SFGVGQILGPLLAGWLAD 344
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
 16-350 4.05e-09

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 57.77  E-value: 4.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  16 AVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASI--AMLGMLGIALAP 93
Cdd:pfam06779   2 TVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLRPALLAGLlaTVLLLLAMAATS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  94 SAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMF------GAEWRLAYGVFAA 167
Cdd:pfam06779  82 SFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGlqlglgGSSLWYGAGVLSA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 168 AACVLAVLAILHVPRTAAPPVQAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVVIGAA 247
Cdd:pfam06779 162 VLTLAVFPLLPRRAPRHASAPAPAAKPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 248 GIAGAGAGALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAALSERPATGLTIA 327
Cdd:pfam06779 242 ALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPRRLLGLM 321

                         330       340
                  ....*....|....*....|...
gi 1222382242 328 FLGIAVGQTLGAPVFGALASWLS 350
Cdd:pfam06779 322 TASFGIGQILGPLLASLLTAATG 344
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-337 9.86e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   2 TREWRLGVTGFGLIAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASI 81
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  82 AMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGA--EWR 159
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlfGWR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 160 LAYGVFAAAACVLAVLAILHVPRT---AAPPVQAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAG 236
Cdd:COG2814   165 WVFLVNAVLALLALLLLLRLLPESrpaARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 237 AGLLWVVIGAAGIAGAGAG-ALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAA 315
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAgRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                         330       340
                  ....*....|....*....|...
gi 1222382242 316 LS-ERPATGLTIAFLGIAVGQTL 337
Cdd:COG2814   325 APpEARGRASGLYNSAFFLGGPL 347
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 15-347 8.82e-11

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 62.71  E-value: 8.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  15 IAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPS 94
Cdd:cd06180     7 LAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  95 AFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSG---PVALMFGAEWRLAYGVFAAAACV 171
Cdd:cd06180    87 FAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGllvPAGLGGGLSWRAGWLALALLSAV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 172 LAVLAILHVPRTAAPPVQAHAGAALFSATLK--RLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVVIGAAGI 249
Cdd:cd06180   167 LLLLSFLLLRRGPSAPTEASAAESAPGLNRPlwRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 250 AGAGAGALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAALSERPATGLTIAFL 329
Cdd:cd06180   247 SCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMTA 326

                         330
                  ....*....|....*...
gi 1222382242 330 GIAVGQTLGAPVFGALAS 347
Cdd:cd06180   327 SFGVGQILGPLLAGWLAD 344
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 30-352 2.01e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 61.80  E-value: 2.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  30 LPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVST 109
Cdd:cd17324    22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 110 GLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGAE--WRLAYGVFAAAACVLAVLAILHVPRTAAPP 187
Cdd:cd17324   102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlgWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 188 VQAHAGAALFSATLKR------LVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVVIGAAGIAGAGAGALVARL 261
Cdd:cd17324   182 PGSLGLLSSLLLLLRNprlrlaYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 262 GIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAALSERPATGLTIAFLGIAVGQTLGAPV 341
Cdd:cd17324   262 GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAAL 341

                         330
                  ....*....|.
gi 1222382242 342 FGALASWLSLT 352
Cdd:cd17324   342 GGLVLDHGGWA 352
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 29-350 4.93e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 60.30  E-value: 4.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  29 FLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVS 108
Cdd:cd17489    18 VLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 109 TGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGAEWrlAYGVFAAAACVLAVLAILHVPRTAAPPV 188
Cdd:cd17489    98 WGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL--GFAVLFIVAAVLALLALLLVFLVKDPPP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 189 QAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIV-------AQRLGWQSAGAGLLwVVIGAAGIAGAGAGALVARL 261
Cdd:cd17489   176 VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIstflplyAAERGISNAGLFFT-VYAIALLLSRPFSGKLSDRK 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 262 GIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAAL-SERPATGLTIAFLGIAVGQTLGAP 340
Cdd:cd17489   255 GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVpPHRRGAANGTFFIFFDLGIGLGGL 334

                         330
                  ....*....|
gi 1222382242 341 VFGALASWLS 350
Cdd:cd17489   335 LLGLVAELFG 344
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
 16-350 4.05e-09

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 57.77  E-value: 4.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  16 AVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASI--AMLGMLGIALAP 93
Cdd:pfam06779   2 TVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLRPALLAGLlaTVLLLLAMAATS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  94 SAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMF------GAEWRLAYGVFAA 167
Cdd:pfam06779  82 SFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGlqlglgGSSLWYGAGVLSA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 168 AACVLAVLAILHVPRTAAPPVQAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVVIGAA 247
Cdd:pfam06779 162 VLTLAVFPLLPRRAPRHASAPAPAAKPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 248 GIAGAGAGALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAALSERPATGLTIA 327
Cdd:pfam06779 242 ALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPRRLLGLM 321

                         330       340
                  ....*....|....*....|...
gi 1222382242 328 FLGIAVGQTLGAPVFGALASWLS 350
Cdd:pfam06779 322 TASFGIGQILGPLLASLLTAATG 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
20-353 8.37e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 56.79  E-value: 8.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  20 GFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLA 99
Cdd:COG0738    21 GFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 100 AAVLLAGVSTGL---ASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALM-FGAEWRLAYGVFAAAACVLAVL 175
Cdd:COG0738   101 LALFLLGLGLGLldvAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgLSLSWHLPYLILAVLLLLLALL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 176 AILH-VPRTAAPPVQAHAGAALFSATLKR-----LVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVVIGAAGI 249
Cdd:COG0738   181 FLRSkLPEIEEEEEEAAGSAASLKSLLKNprlllGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMT 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 250 AG-AGAGALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAyitLSGIY-LVWGVAALSERPATGLTIA 327
Cdd:COG0738   261 IGrFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG---LSLMFpTIFSLALDGLGKRTAAAVS 337

                         330       340
                  ....*....|....*....|....*...
gi 1222382242 328 FLGIA--VGQTLGAPVFGALASWLSLTH 353
Cdd:COG0738   338 AVLIMgiVGGAIGPPLIGFLADAFGLRA 365
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
2-352 3.40e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.88  E-value: 3.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   2 TREWRLGVTGFGLIAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASI 81
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  82 AMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGAE--WR 159
Cdd:COG2271    85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAfgWR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 160 LAYGVFAAaacvlavlailhvprtaappvqahAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGL 239
Cdd:COG2271   165 AAFLILGL------------------------PGLLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 240 L-WVVIGAAGIAGAGAGALVARLGID--WAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGVAAL 316
Cdd:COG2271   221 LlSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1222382242 317 S-ERPATGLTIAFLGIAVGQTLGAPVFGALASWLSLT 352
Cdd:COG2271   301 PkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-348 1.26e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.20  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  12 FGLIAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIAL 91
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  92 APSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDG----TNTLINAGTSAGVILSGPVALMFGAEWRLAYGVFAA 167
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRalglLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 168 AACVLAVLAILHVPRTAAPPVQ-----------AHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAG 236
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAkneeassksvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 237 AGLLWVVIGAAGIAGAGAGALVARLGIDWAHRL---CLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGV 313
Cdd:cd06174   241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLligLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1222382242 314 AALSERPATGLTIAFLGIAVGQTLGAPVFGALASW 348
Cdd:cd06174   321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
MFS_1 pfam07690
Major Facilitator Superfamily;
12-339 1.29e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.81  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  12 FGLIAVCYGFARFAFGLFLPQ-IDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIA 90
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  91 LAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGAE--WRLAYGVFAAA 168
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfgWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 169 ACVLAVLAILHVPRTAAPPVQAHAGAALFSATLKRLV--------VASLLMGAASTALWSFGSEIVAQRLGW-QSAGAGL 239
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALlrdpvlwlLLALLLFGFAFFGLLTYLPLYQEVLGLsALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 240 LWVVIGAAGIAGAGAGALVARLGID---WAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVWGV-AA 315
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSdLA 320

                         330       340
                  ....*....|....*....|....
gi 1222382242 316 LSERPATGLTIAFLGIAVGQTLGA 339
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
7-297 3.68e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 48.33  E-value: 3.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   7 LGVTGFGLIAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGM 86
Cdd:COG2807    18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  87 LGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGT---NTLINAGTSAGVILSGPVALMFGaeWRLAYG 163
Cdd:COG2807    98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTglyTAAMGLGAALAAGLTVPLAAALG--WRGALA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 164 VFAAAACVLAVLAILHVPRTAAPPVQAHAGAALFSATLKRLVVA-SLLMGAASTALWSFGSEIVA--QRLGWQSAGAGLL 240
Cdd:COG2807   176 VWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLlTLFFGLQSLLYYAVVAWLPPilRDAGLSAATAGLL 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1222382242 241 WVVIGAAGIAGAGAGALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALF 297
Cdd:COG2807   256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVL 312
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 24-286 4.33e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.88  E-value: 4.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  24 FAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVL 103
Cdd:COG0477    31 TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 104 LAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPV--ALMFGAEWRLAYGVfAAAACVLAVLAILHVP 181
Cdd:COG0477   111 LQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLggLLVAALGWRWIFLI-NAPLGLLALVLRLRLP 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 182 RTAAPPVQAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVVIGAAGIAGAGAGALVARL 261
Cdd:COG0477   190 ESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLL 269

                         250       260
                  ....*....|....*....|....*
gi 1222382242 262 GIDWAHRLCLAALAAAIVLVGMGGA 286
Cdd:COG0477   270 LLLALLLALLLLLLLLLLLLLLALL 294
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 29-351 4.54e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.34  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  29 FLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVS 108
Cdd:cd17325    18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 109 TGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILsGPVALMFGAEW---RLAYGVFAAAACVLAVLAILHVPRTAA 185
Cdd:cd17325    98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLI-GPLLGGLLADAlgyRAPFLVCAALALLALVLALLLLPEPRP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 186 PPVQAHAGAALFSATLKRLV---------VASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLW-VVIGAAGIAGAGAG 255
Cdd:cd17325   177 PPNKRAVSAARLRSGLRLLLrdrrllalfLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFgAQGLASALSQPPAG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 256 ALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLGGALFGAAYITLSGIYLVwGVAALSERPATGLTIAFLGIA--V 333
Cdd:cd17325   257 KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA-LLADIVPPEGRGTAMGLFNTAfsL 335

                         330
                  ....*....|....*...
gi 1222382242 334 GQTLGAPVFGALASWLSL 351
Cdd:cd17325   336 GMVLGPLLGGFLYDAFGF 353
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
21-348 1.07e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.18  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  21 FARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAA 100
Cdd:COG2223    19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 101 AVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFGAE--WRLAYGVFAAAACVLAVLAIL 178
Cdd:COG2223    99 LGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfgWRNAFLILGILLLVVAVLAWL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 179 HVPRTAAPPVQAHA------GAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLL-WVVIGAAGIAG 251
Cdd:COG2223   179 FLRDPPAGAAAAAKaslrdqLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLaALFALLGALGR 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 252 AGAGALVARLGIDWAHRLCLAALAAAIVLVG--MGGAPALVLLGGALFGAAYITLSGIYLVWGVAALSERPATGLTIAFL 329
Cdd:COG2223   259 PLGGWLSDRIGGRRVLLIVFALMALGLLLLAlaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGA 338

                         330
                  ....*....|....*....
gi 1222382242 330 GIAVGQTLGAPVFGALASW 348
Cdd:COG2223   339 AGGLGGFLGPLLFGALLDA 357
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 12-151 1.19e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.69  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  12 FGLIAVCYGFARFAFGLFLPQIdADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIAL 91
Cdd:cd17370   205 YLLAVALFALGNFSFAFLILRA-QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  92 APSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVA 151
Cdd:cd17370   284 GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIA 343
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 2-147 1.24e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.85  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   2 TREWRLGVTGFGLIAVCYGFARFAFGLFLPQIDADL-ALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAAS 80
Cdd:cd17333   194 RLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKkHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGS 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1222382242  81 IAMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILS 147
Cdd:cd17333   274 GALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIP 340
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 11-158 1.88e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.95  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  11 GFGLIAVCYGFARFAFGLFLP-QIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGI 89
Cdd:cd17325   203 ALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1222382242  90 ALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGT----NTLINAGTSAGVILSGPVALMFGAEW 158
Cdd:cd17325   283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAmglfNTAFSLGMVLGPLLGGFLYDAFGFAT 355
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 8-158 2.02e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.94  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   8 GVTGFGLIAVCYGFARFAFGLFLPQIDADL--ALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLG 85
Cdd:cd17474   199 GLLTFLVSAFLYFFLYFAFLTYLPFLLELLygISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS 278

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1222382242  86 MLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGT----NTLINAGTSAGVILSGPVALMFGAEW 158
Cdd:cd17474   279 LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAsslyNFVRFLGQAVGPLLFGLLLEIFGLSA 355
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 17-350 2.36e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 43.00  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  17 VCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAF 96
Cdd:cd17475     6 AAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  97 WLAAAVLLAGVSTGLASPPMAAAVAAIVqPQRQDGT-----NTLINAGTSAGVILSGPVALMFGaeWRLAYGVFAAAACV 171
Cdd:cd17475    86 VLLVLLFLVGAGYGSVQPGGGRAIMRWF-PPRERGLamgirQTGVPLGGALAAALLPPLALHYG--WRAAFVVAGLVSIL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 172 LAVLAIL--------HVPRTAAPPVQAHAGAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQRLGWQSAGAGLLWVV 243
Cdd:cd17475   163 AAVLFWLfyreppaaSAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 244 IGAAGIAGAGAGALVA--------RLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLgGALFGAAYITLSGIYLVWgVAA 315
Cdd:cd17475   243 AQLGGALGRIGLGRVSdrvfggrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLL-LILLGLFAIGWNGLYLTL-VAE 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1222382242 316 LSERPATGL------TIAFLGIAVgqtlGAPVFGALASWLS 350
Cdd:cd17475   321 SAGPEQAGTalglanTINFIGIAI----GPPLFGLLVDATH 357
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 45-163 2.72e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 42.72  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  45 GLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIV 124
Cdd:cd17362    42 GLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETS 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1222382242 125 QPQRQDGTNTLINAGTSAGVILSGPVALMFGAE---WRLAYG 163
Cdd:cd17362   122 PSHIRGLLVSLKELFIVLGILLGYVSGYAFADVvggWRYMYG 163
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 45-151 1.14e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 40.68  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  45 GLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVL--LAGVSTGLASPPMAAAVAA 122
Cdd:cd17318    59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLriLQGLAQGVTFPAMHALWAK 138

                          90       100
                  ....*....|....*....|....*....
gi 1222382242 123 IVQPQRQDGTNTLINAGTSAGVILSGPVA 151
Cdd:cd17318   139 WAPPLERSRLTSIAYSGSQFGTVIAMPLS 167
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-147 1.81e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   5 WRLGVTGFGLIAVCYGFARFAFGLFLPQI-DADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAM 83
Cdd:COG2814   205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYlQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1222382242  84 LGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILS 147
Cdd:COG2814   285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 30-123 2.48e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 39.55  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  30 LPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVST 109
Cdd:cd17393    22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101

                          90
                  ....*....|....
gi 1222382242 110 GLASPPMAAAVAAI 123
Cdd:cd17393   102 GALDVAMNAQGVAV 115
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 23-165 2.57e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.48  E-value: 2.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  23 RFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAV 102
Cdd:cd17319    19 RVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLR 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1222382242 103 LLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPV--ALMFGAEWRLAYGVF 165
Cdd:cd17319    99 FLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLsgWLLLLFGWRWAFIIE 163
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 13-152 2.94e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  13 GLIAVCYGFARFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALA 92
Cdd:cd17365     5 FLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  93 PSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVAL 152
Cdd:cd17365    85 QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAA 144
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 30-129 5.40e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 38.71  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  30 LPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVST 109
Cdd:cd17503    19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98

                          90       100
                  ....*....|....*....|
gi 1222382242 110 GLASPPMAAAVAAIVQPQRQ 129
Cdd:cd17503    99 GVLIPLAQTILLRIYPPEKR 118
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 52-162 5.57e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 38.33  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  52 FLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDG 131
Cdd:cd17317    35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSF 114

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1222382242 132 TNTLINAGTSAGVILSGPVALMFGaEWRLAY 162
Cdd:cd17317   115 VGILFGLFWALGYMLLALLAYLIR-DWRWLQ 144
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 20-155 6.25e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.36  E-value: 6.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  20 GFARFAFGLFLPQI----DADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSA 95
Cdd:cd17329     9 FLNRLGFFMVWPFMaiylHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  96 FWLAAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGPVALMFG 155
Cdd:cd17329    89 WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL 148
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 40-147 6.58e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.33  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  40 PDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAMLGMLGIALAPSAFWLAAAVLLAGVSTGLASPPMAAA 119
Cdd:cd17330   209 PSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSAL 288

                          90       100
                  ....*....|....*....|....*...
gi 1222382242 120 VAAIVQPQRQDGTNTLINAGTSAGVILS 147
Cdd:cd17330   289 LSKSVPSKEQGKAQGIIQSLQSLARIIG 316
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 5-349 7.26e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.02  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242   5 WRLGVTGFGLIAVCYGFaRFAFGLFLPQIDADLALPDAVGGLIAGGSFLGYCLAIVVAAQLTERLGARTVAFVAASIAML 84
Cdd:cd17355     2 WVVLAVTFLILILSWGI-RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242  85 GMLGIALAPSAFWL-AAAVLLAGVSTGLASPPMAAAVAAIVQPQRQDGTNTLINAGTSAGVILSGP--VALMFGAEWRLA 161
Cdd:cd17355    81 GLVLLALATSLWQLyLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPlgAALIEAFGWRTA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 162 YGVFAAAACVLAVLAILHVPRTAAPPVQAHA------------GAALFSATLKRLVVASLLMGAASTALWSFGSEIVAQR 229
Cdd:cd17355   161 LLVLALLALLVLVPVLLLLRRRPADLALRAYddaspaspgstlKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222382242 230 LGWQSAGAGLLWVVIGAAGIAGAGAGALVARLGIDWAHRLCLAALAAAIVLVGMGGAPALVLLG-GALFGAAYITLSGIY 308
Cdd:cd17355   241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLT 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1222382242 309 LVW-GVAALSERPATGLTIAFLGIAVGQTLGAPVFGALASWL 349
Cdd:cd17355   321 AALaARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRT 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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