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Conserved domains on  [gi|1223564276|ref|WP_091600646|]
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adenylate/guanylate cyclase domain-containing protein [Mesorhizobium muleiense]

Protein Classification

adenylate/guanylate cyclase domain-containing protein( domain architecture ID 11573933)

adenylate/guanylate cyclase domain-containing protein with a TolB_N domain and tetratricopeptide (TPR) repeats, may function as an adenylate cyclase, catalyzing the synthesis of 3',5'-cyclic AMP, or as a guanylate cyclase, catalyzing the synthesis of 3',5'-cyclic GMP

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
193-323 6.11e-67

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


:

Pssm-ID: 444347  Cd Length: 135  Bit Score: 213.98  E-value: 6.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 193 STAAPPQLSIAVLPFANMSGDAEQEYFADGISEDIITALSKLSQLFVIARNSSFTFKGRNVNVQEVGRNLGVHYVLEGSV 272
Cdd:COG5616     4 APAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLEGSV 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1223564276 273 RKSGNKVRITAQLIDATTGGHLWAERFDRDLTDIFAVQDDVTQQIVDALAL 323
Cdd:COG5616    84 RRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAALAP 134
CHD cd07302
cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also ...
8-171 3.77e-42

cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.


:

Pssm-ID: 143636 [Multi-domain]  Cd Length: 177  Bit Score: 149.65  E-value: 3.77e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   8 AAILAADVVGYSRLASA-DEDRTLARLRALRSdLIDPTIAVYNGRMVKRTGDGALVEF-------RSVVDAVRCAIEVQD 79
Cdd:cd07302     2 VTVLFADIVGFTALSERlGPEELVELLNEYFS-AFDEIIERHGGTVDKTIGDAVMAVFglpgaheDHAERAVRAALEMQE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276  80 GMVERNAGVPEDRRIEFRIGIHLGDVV------EESDGDLMGDGVNIASRLEGVAAPGTICLSEDAYRQVKtRLDVSVSD 153
Cdd:cd07302    81 ALAELNAEREGGPPLRLRIGIHTGPVVagvvgsERPEYTVIGDTVNLAARLESLAKPGQILVSEATYELLG-DAGFEFEE 159
                         170
                  ....*....|....*...
gi 1223564276 154 LGDTQLKNIAEPIRVYSL 171
Cdd:cd07302   160 LGEVELKGKSGPVRVYRL 177
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-569 7.83e-25

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 103.55  E-value: 7.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 373 VEFDPKFAPAYAFLAfaNILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIA 452
Cdd:COG0457     1 LELDPDDAEAYNNLG--LAYRRLGRY--------EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 453 LAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHfQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVL 532
Cdd:COG0457    71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN-LGLALLELGRYDEAIEAYERALELDPDDADALYN 149
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1223564276 533 LAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVL 569
Cdd:COG0457   150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEA 186
 
Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
193-323 6.11e-67

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 213.98  E-value: 6.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 193 STAAPPQLSIAVLPFANMSGDAEQEYFADGISEDIITALSKLSQLFVIARNSSFTFKGRNVNVQEVGRNLGVHYVLEGSV 272
Cdd:COG5616     4 APAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLEGSV 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1223564276 273 RKSGNKVRITAQLIDATTGGHLWAERFDRDLTDIFAVQDDVTQQIVDALAL 323
Cdd:COG5616    84 RRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAALAP 134
CHD cd07302
cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also ...
8-171 3.77e-42

cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.


Pssm-ID: 143636 [Multi-domain]  Cd Length: 177  Bit Score: 149.65  E-value: 3.77e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   8 AAILAADVVGYSRLASA-DEDRTLARLRALRSdLIDPTIAVYNGRMVKRTGDGALVEF-------RSVVDAVRCAIEVQD 79
Cdd:cd07302     2 VTVLFADIVGFTALSERlGPEELVELLNEYFS-AFDEIIERHGGTVDKTIGDAVMAVFglpgaheDHAERAVRAALEMQE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276  80 GMVERNAGVPEDRRIEFRIGIHLGDVV------EESDGDLMGDGVNIASRLEGVAAPGTICLSEDAYRQVKtRLDVSVSD 153
Cdd:cd07302    81 ALAELNAEREGGPPLRLRIGIHTGPVVagvvgsERPEYTVIGDTVNLAARLESLAKPGQILVSEATYELLG-DAGFEFEE 159
                         170
                  ....*....|....*...
gi 1223564276 154 LGDTQLKNIAEPIRVYSL 171
Cdd:cd07302   160 LGEVELKGKSGPVRVYRL 177
AcyC COG2114
Adenylate cyclase, class 3 [Signal transduction mechanisms];
1-172 1.47e-38

Adenylate cyclase, class 3 [Signal transduction mechanisms];


Pssm-ID: 441717 [Multi-domain]  Cd Length: 407  Bit Score: 146.87  E-value: 1.47e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   1 MSESRKLAAILAADVVGYSRLASADEDRTLARLRALRSDLIDPTIAVYNGRMVKRTGDGALVEFRSVV-------DAVRC 73
Cdd:COG2114   216 LGGERREVTVLFADIVGFTALSERLGPEELVELLNRYFSAMVEIIERHGGTVDKFIGDGVMAVFGAPVaredhaeRAVRA 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276  74 AIEVQDGMVERNAGVPE--DRRIEFRIGIHLGDVV-------EESDGDLMGDGVNIASRLEGVAAPGTICLSEDAYRQVK 144
Cdd:COG2114   296 ALAMQEALAELNAELPAegGPPLRVRIGIHTGEVVvgnigseDRLDYTVIGDTVNLAARLESLAKPGEILVSEATYDLLR 375
                         170       180
                  ....*....|....*....|....*...
gi 1223564276 145 TRLDvsVSDLGDTQLKNIAEPIRVYSLR 172
Cdd:COG2114   376 DRFE--FRELGEVRLKGKAEPVEVYELL 401
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-569 7.83e-25

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 103.55  E-value: 7.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 373 VEFDPKFAPAYAFLAfaNILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIA 452
Cdd:COG0457     1 LELDPDDAEAYNNLG--LAYRRLGRY--------EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 453 LAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHfQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVL 532
Cdd:COG0457    71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN-LGLALLELGRYDEAIEAYERALELDPDDADALYN 149
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1223564276 533 LAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVL 569
Cdd:COG0457   150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEA 186
CYCc smart00044
Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl ...
2-141 2.59e-13

Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl cyclases. Eubacterial homologues are known. Two residues (Asn, Arg) are thought to be involved in catalysis. These cyclases have important roles in a diverse range of cellular processes.


Pssm-ID: 214485  Cd Length: 194  Bit Score: 68.82  E-value: 2.59e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276    2 SESRKLAAILAADVVGYSRLASAdedRTLARLRALRSDL---IDPTIAVYNGRMVKRTGDGALVEFRSVVDA-VRCAIEV 77
Cdd:smart00044  31 AESYDNVTILFSDIVGFTSLCST---STPEQVVNLLNDLysrFDQIIDRHGGYKVKTIGDAYMVASGLPEEAlVDHAELI 107
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1223564276   78 QD---GMVE--RNAGVP-EDRRIEFRIGIHLGDVVEESDG------DLMGDGVNIASRLEGVAAPGTICLSEDAYR 141
Cdd:smart00044 108 ADealDMVEelKTVLVQhREEGLRVRIGIHTGPVVAGVVGirmpryCLFGDTVNLASRMESAGDPGQIQVSEETYS 183
Guanylate_cyc pfam00211
Adenylate and Guanylate cyclase catalytic domain;
9-160 7.47e-12

Adenylate and Guanylate cyclase catalytic domain;


Pssm-ID: 425528  Cd Length: 183  Bit Score: 64.19  E-value: 7.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   9 AILAADVVGYSRLASADEDRTLAR-LRALRSDlIDPTIAVYNGRMVKRTGDGALVEF---RSVVDAVRCAIEVQDGMVE- 83
Cdd:pfam00211  10 TILFADIVGFTALSSRHSPEQVVRlLNELYTR-FDRLLDKHKVYKVKTIGDAYMVVSglpEPSPAHARKIAEMALDMLEa 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276  84 -RNAGVPEDRRIEFRIGIHLGDVVEESDG------DLMGDGVNIASRLEGVAAPGTICLSEDAYRQVKtRLDVSVSDLGD 156
Cdd:pfam00211  89 iGEVNVESSEGLRVRVGIHTGPVVAGVIGarmpryDLWGNTVNLASRMESTGVPGKIHVSEETYRLLK-TEGFEFTERGE 167

                  ....
gi 1223564276 157 TQLK 160
Cdd:pfam00211 168 IEVK 171
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
364-559 4.14e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 62.79  E-value: 4.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 364 KGRELLQRAVEFDPKFAPAYAFLAfaNILDYANQwssswsnaMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAA 443
Cdd:TIGR02917 177 EARALIDEVLTADPGNVDALLLKG--DLLLSLGN--------IELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 444 ICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP-YYPDVYLhfQAQAMFQLRRYEEAIGILRRRLSR 522
Cdd:TIGR02917 247 EKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPeYLPALLL--AGASEYQLGNLEQAYQYLNQILKY 324
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1223564276 523 NPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQ 559
Cdd:TIGR02917 325 APNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPD 361
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
194-489 2.74e-07

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 53.32  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 194 TAAPPQLSIAVLPFaNMSGDAEQEyfadGISEDIITALSKLSQLFVIARNSSFTFKGRNV-NVQEVGRNLGVHYVLEGSV 272
Cdd:PRK12370  116 APQPTTHTLAILPF-QMQDQVQSE----SLHYSIVKGLSQYAPFGLSVLPVTITKNCRSVkDILELMDQLRPDYYISGQM 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 273 RKSGNKVRITAQLIDATTGGHLWAERFDRDLTDIFAVqddVTQQIVDALALNLAKGDQQRLATEQTGNLDAYDCFLHGRE 352
Cdd:PRK12370  191 IPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASL---LQNKIANLLLRCIPGLRWDTKQISELNSIDSTMVYLRGKH 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 353 QLWRFTKAENIKGRELLQRAVEFDPKFAPAYAFLAFANiLDYANQWSSSWSNAMAQAEMFAARAVALDDRYPYAhwaLGI 432
Cdd:PRK12370  268 ELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECY-LSMAQMGIFDKQNAMIKAKEHAIKATELDHNNPQA---LGL 343
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 433 VELYSRRHEAAICSA---KRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP 489
Cdd:PRK12370  344 LGLINTIHSEYIVGSllfKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLDP 403
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
475-547 3.52e-06

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 45.32  E-value: 3.52e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1223564276 475 EDALRCFDRAMALNPYYPDvYLHFQAQAMFQLRRYEEAIGILRRRLSRNPSTDvSRVLLAASYGHLGRFEEAR 547
Cdd:pfam12895   6 KNAIFLAERLLAAEPESPE-DAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLG-CRYLFAQCLLKLKKYDEAL 76
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
458-489 1.09e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1223564276  458 AEGHENLGYALHYSGKPEDALRCFDRAMALNP 489
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
FlgO pfam17680
FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio ...
185-291 2.12e-03

FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.


Pssm-ID: 435970  Cd Length: 130  Bit Score: 38.64  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 185 HELSEALLSTAAPPQL--SIAVLPFANMSGDAEQEYFADGISEDIITALS---------KLSQLFVIARNSSFTFKgRNV 253
Cdd:pfam17680   1 YQLADQLLANLDPLLLrrPIAVTSFVDLDDLQQTSTLGRQLSESLITELQqrgysvveyKLTDSIRVTEEGEFALS-RDL 79
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1223564276 254 nvQEVGRNLGVHYVLEGSVRKSGNKVRITAQLIDATTG 291
Cdd:pfam17680  80 --RELAETQNADYVLVGTYTVTRDGVLVNARLIDLKDN 115
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
441-524 2.97e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 441 EAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP-YYPDVYLHfqaqaMFQL-------RRYEEA 512
Cdd:cd24142    17 ELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPdGGYEKYLY-----LGQLsggeealQYYEKG 91
                          90
                  ....*....|..
gi 1223564276 513 IGILRRRLSRNP 524
Cdd:cd24142    92 IEILEEELQALQ 103
 
Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
193-323 6.11e-67

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 213.98  E-value: 6.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 193 STAAPPQLSIAVLPFANMSGDAEQEYFADGISEDIITALSKLSQLFVIARNSSFTFKGRNVNVQEVGRNLGVHYVLEGSV 272
Cdd:COG5616     4 APAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLEGSV 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1223564276 273 RKSGNKVRITAQLIDATTGGHLWAERFDRDLTDIFAVQDDVTQQIVDALAL 323
Cdd:COG5616    84 RRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAALAP 134
CHD cd07302
cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also ...
8-171 3.77e-42

cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.


Pssm-ID: 143636 [Multi-domain]  Cd Length: 177  Bit Score: 149.65  E-value: 3.77e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   8 AAILAADVVGYSRLASA-DEDRTLARLRALRSdLIDPTIAVYNGRMVKRTGDGALVEF-------RSVVDAVRCAIEVQD 79
Cdd:cd07302     2 VTVLFADIVGFTALSERlGPEELVELLNEYFS-AFDEIIERHGGTVDKTIGDAVMAVFglpgaheDHAERAVRAALEMQE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276  80 GMVERNAGVPEDRRIEFRIGIHLGDVV------EESDGDLMGDGVNIASRLEGVAAPGTICLSEDAYRQVKtRLDVSVSD 153
Cdd:cd07302    81 ALAELNAEREGGPPLRLRIGIHTGPVVagvvgsERPEYTVIGDTVNLAARLESLAKPGQILVSEATYELLG-DAGFEFEE 159
                         170
                  ....*....|....*...
gi 1223564276 154 LGDTQLKNIAEPIRVYSL 171
Cdd:cd07302   160 LGEVELKGKSGPVRVYRL 177
AcyC COG2114
Adenylate cyclase, class 3 [Signal transduction mechanisms];
1-172 1.47e-38

Adenylate cyclase, class 3 [Signal transduction mechanisms];


Pssm-ID: 441717 [Multi-domain]  Cd Length: 407  Bit Score: 146.87  E-value: 1.47e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   1 MSESRKLAAILAADVVGYSRLASADEDRTLARLRALRSDLIDPTIAVYNGRMVKRTGDGALVEFRSVV-------DAVRC 73
Cdd:COG2114   216 LGGERREVTVLFADIVGFTALSERLGPEELVELLNRYFSAMVEIIERHGGTVDKFIGDGVMAVFGAPVaredhaeRAVRA 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276  74 AIEVQDGMVERNAGVPE--DRRIEFRIGIHLGDVV-------EESDGDLMGDGVNIASRLEGVAAPGTICLSEDAYRQVK 144
Cdd:COG2114   296 ALAMQEALAELNAELPAegGPPLRVRIGIHTGEVVvgnigseDRLDYTVIGDTVNLAARLESLAKPGEILVSEATYDLLR 375
                         170       180
                  ....*....|....*....|....*...
gi 1223564276 145 TRLDvsVSDLGDTQLKNIAEPIRVYSLR 172
Cdd:COG2114   376 DRFE--FRELGEVRLKGKAEPVEVYELL 401
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-569 7.83e-25

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 103.55  E-value: 7.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 373 VEFDPKFAPAYAFLAfaNILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIA 452
Cdd:COG0457     1 LELDPDDAEAYNNLG--LAYRRLGRY--------EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 453 LAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHfQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVL 532
Cdd:COG0457    71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN-LGLALLELGRYDEAIEAYERALELDPDDADALYN 149
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1223564276 533 LAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVL 569
Cdd:COG0457   150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEA 186
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
367-560 1.25e-22

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 102.38  E-value: 1.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 367 ELLQRAVEFDPKFAPAYAFLAFANILDYANQWSS-SWSNAMAQAEMFAARAVALDDRYPYAHWALGIVELysRRHEAAIC 445
Cdd:COG3914    22 AAAELALAAELEAAALAAALGLALLLLAALAEAAaAALLALAAGEAAAAAAALLLLAALLELAALLLQAL--GRYEEALA 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 446 SAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHfQAQAMFQLRRYEEAIGILRRRLSRNPS 525
Cdd:COG3914   100 LYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLN-LGEALRRLGRLEEAIAALRRALELDPD 178
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1223564276 526 TDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQY 560
Cdd:COG3914   179 NAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
417-587 2.89e-22

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 96.23  E-value: 2.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 417 VALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYL 496
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 497 HfQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPND 576
Cdd:COG0457    81 N-LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159
                         170
                  ....*....|.
gi 1223564276 577 FELIVDGLRKA 587
Cdd:COG0457   160 YEEALELLEKL 170
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
367-562 5.62e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.17  E-value: 5.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 367 ELLQRAVEFDPKFAPAYAFLAfaniLDYANQwssswsNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICS 446
Cdd:COG2956    63 RIHQKLLERDPDRAEALLELA----QDYLKA------GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEV 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 447 AKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLhFQAQAMFQLRRYEEAIGILRRRLSRNPST 526
Cdd:COG2956   133 LERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALL-LLAELYLEQGDYEEAIAALERALEQDPDY 211
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1223564276 527 DVSRVLLAASYGHLGRFEEARREWQEVFRVNPQYSL 562
Cdd:COG2956   212 LPALPRLAELYEKLGDPEEALELLRKALELDPSDDL 247
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
320-557 4.30e-19

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 91.21  E-value: 4.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 320 ALALNLAKGDQQRLATEQTGNLDAYDCFLHGREQLWRFTKAENIKGRELLQRAVEFDPKFAPAYAFLAFANILDYANQWS 399
Cdd:COG3914    11 ALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 400 SswsNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALR 479
Cdd:COG3914    91 L---GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1223564276 480 CFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVN 557
Cdd:COG3914   168 ALRRALELDPDNAEALNNL-GNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALA 244
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
367-549 2.94e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 84.67  E-value: 2.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 367 ELLQRAVEFDPKFAPAYAFLafANILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICS 446
Cdd:COG0457    29 EDYEKALELDPDDAEALYNL--GLAYLRLGRY--------EEALADYEQALELDPDDAEALNNLGLALQALGRYEEALED 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 447 AKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNPST 526
Cdd:COG0457    99 YDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNL-GIALEKLGRYEEALELLEKLEAAALAA 177
                         170       180
                  ....*....|....*....|...
gi 1223564276 527 DVSRVLLAASYGHLGRFEEARRE 549
Cdd:COG0457   178 LLAAALGEAALALAAAEVLLALL 200
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
320-518 3.41e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 88.51  E-value: 3.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 320 ALALNLAKGDQQRLATEQTGNLDAYDCFLHGREQLWRFTKAEnikgrELLQRAVEFDPKFAPAYAFLAfaNILDYANQWs 399
Cdd:COG3914    57 AALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEAL-----ALYRRALALNPDNAEALFNLG--NLLLALGRL- 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 400 sswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALR 479
Cdd:COG3914   129 -------EEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIA 201
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1223564276 480 CFDRAMALNPYYPDVYLH-----FQAQAMFQLRRYEEAIGILRR 518
Cdd:COG3914   202 AYRRALELDPDNADAHSNllfalRQACDWEVYDRFEELLAALAR 245
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
426-560 3.68e-18

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 81.01  E-value: 3.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 426 AHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQ 505
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL-GLALLK 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1223564276 506 LRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQY 560
Cdd:COG4783    85 AGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
364-587 4.22e-18

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 84.78  E-value: 4.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 364 KGRELLQRAVEFDPKFAPAYafLAFANILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAA 443
Cdd:COG2956    26 KAIDLLEEALELDPETVEAH--LALGNLYRRRGEY--------DRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 444 ICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHfQAQAMFQLRRYEEAIGILRRRLSRN 523
Cdd:COG2956    96 EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCE-LAELYLEQGDYDEAIEALEKALKLD 174
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1223564276 524 PSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPNDFELIVDGLRKA 587
Cdd:COG2956   175 PDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKA 238
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
380-524 1.15e-17

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 79.85  E-value: 1.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 380 APAYAFLAFANILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAE 459
Cdd:COG4783     2 ACAEALYALAQALLLAGDY--------DEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1223564276 460 GHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHfQAQAMFQLRRYEEAIGILRRRLSRNP 524
Cdd:COG4783    74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR-LARAYRALGRPDEAIAALEKALELDP 137
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
442-558 6.98e-17

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 77.35  E-value: 6.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 442 AAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLS 521
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDL-AEALLAAGDTEEAEELLERALA 79
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1223564276 522 RNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNP 558
Cdd:COG4235    80 LDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
386-587 6.97e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.73  E-value: 6.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 386 LAFANILDYANQWSSSWSNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALA----PNLAEGH 461
Cdd:COG3914     2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAaaalLLLAALL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 462 ENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLG 541
Cdd:COG3914    82 ELAALLLQALGRYEEALALYRRALALNPDNAEALFNL-GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1223564276 542 RFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPNDFELIVDGLRKA 587
Cdd:COG3914   161 RLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRA 206
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
356-555 1.12e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.38  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 356 RFTKAEnikgrELLQRAVEFDPKFAPAYAFLAfaNILDYANQWSsswsNAMAQAEmfaaRAVALDDRYPYAHWALGIVEL 435
Cdd:COG2956    91 LLDRAE-----ELLEKLLELDPDDAEALRLLA--EIYEQEGDWE----KAIEVLE----RLLKLGPENAHAYCELAELYL 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 436 YSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGI 515
Cdd:COG2956   156 EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRL-AELYEKLGDPEEALEL 234
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1223564276 516 LRRRLSRNPSTDVsRVLLAASYGHLGRFEEARREWQEVFR 555
Cdd:COG2956   235 LRKALELDPSDDL-LLALADLLERKEGLEAALALLERQLR 273
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
408-535 1.21e-14

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 70.81  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 408 QAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMAL 487
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1223564276 488 NPYYPDVyLHFQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAA 535
Cdd:COG4235    81 DPDNPEA-LYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEAS 127
CYCc smart00044
Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl ...
2-141 2.59e-13

Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl cyclases. Eubacterial homologues are known. Two residues (Asn, Arg) are thought to be involved in catalysis. These cyclases have important roles in a diverse range of cellular processes.


Pssm-ID: 214485  Cd Length: 194  Bit Score: 68.82  E-value: 2.59e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276    2 SESRKLAAILAADVVGYSRLASAdedRTLARLRALRSDL---IDPTIAVYNGRMVKRTGDGALVEFRSVVDA-VRCAIEV 77
Cdd:smart00044  31 AESYDNVTILFSDIVGFTSLCST---STPEQVVNLLNDLysrFDQIIDRHGGYKVKTIGDAYMVASGLPEEAlVDHAELI 107
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1223564276   78 QD---GMVE--RNAGVP-EDRRIEFRIGIHLGDVVEESDG------DLMGDGVNIASRLEGVAAPGTICLSEDAYR 141
Cdd:smart00044 108 ADealDMVEelKTVLVQhREEGLRVRIGIHTGPVVAGVVGirmpryCLFGDTVNLASRMESAGDPGQIQVSEETYS 183
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
372-552 5.81e-13

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 68.40  E-value: 5.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 372 AVEFDPKFAPAYAFLAFANILDYANQWSSSWSNAMAQAEMFAARAVALDD-----RYPYAHWALGIVELYSRR------- 439
Cdd:COG4785     7 ALLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAalaaeRIDRALALPDLAQLYYERgvaydsl 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 440 --HEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHfQAQAMFQLRRYEEAIGILR 517
Cdd:COG4785    87 gdYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN-RGIALYYLGRYELAIADLE 165
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1223564276 518 RRLSRNPStDVSRVLLAASYGHLGRFEEARREWQE 552
Cdd:COG4785   166 KALELDPN-DPERALWLYLAERKLDPEKALALLLE 199
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
458-588 1.32e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.21  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 458 AEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASY 537
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALL-GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1223564276 538 GHLGRFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPNDFELIVDGLRKAG 588
Cdd:COG4783    83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKAL 133
Nucleotidyl_cyc_III cd07556
Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse ...
7-133 4.28e-12

Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.


Pssm-ID: 143637 [Multi-domain]  Cd Length: 133  Bit Score: 63.53  E-value: 4.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   7 LAAILAADVVGYSRLASADEDRTLARLRALRSDLIDPTIAVYNGRMVKRTGDGALVEFRsvVDAVRCAIEVQDGMVERNA 86
Cdd:cd07556     1 PVTILFADIVGFTSLADALGPDEGDELLNELAGRFDSLIRRSGDLKIKTIGDEFMVVSG--LDHPAAAVAFAEDMREAVS 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1223564276  87 GVPEDRR--IEFRIGIHLGDVV-----EESDGDLMGDGVNIASRLEGVAAPGTI 133
Cdd:cd07556    79 ALNQSEGnpVRVRIGIHTGPVVvgvigSRPQYDVWGALVNLASRMESQAKAGQV 132
Guanylate_cyc pfam00211
Adenylate and Guanylate cyclase catalytic domain;
9-160 7.47e-12

Adenylate and Guanylate cyclase catalytic domain;


Pssm-ID: 425528  Cd Length: 183  Bit Score: 64.19  E-value: 7.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276   9 AILAADVVGYSRLASADEDRTLAR-LRALRSDlIDPTIAVYNGRMVKRTGDGALVEF---RSVVDAVRCAIEVQDGMVE- 83
Cdd:pfam00211  10 TILFADIVGFTALSSRHSPEQVVRlLNELYTR-FDRLLDKHKVYKVKTIGDAYMVVSglpEPSPAHARKIAEMALDMLEa 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276  84 -RNAGVPEDRRIEFRIGIHLGDVVEESDG------DLMGDGVNIASRLEGVAAPGTICLSEDAYRQVKtRLDVSVSDLGD 156
Cdd:pfam00211  89 iGEVNVESSEGLRVRVGIHTGPVVAGVIGarmpryDLWGNTVNLASRMESTGVPGKIHVSEETYRLLK-TEGFEFTERGE 167

                  ....
gi 1223564276 157 TQLK 160
Cdd:pfam00211 168 IEVK 171
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
405-558 1.07e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 63.06  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 405 AMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRA 484
Cdd:COG5010     1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1223564276 485 MALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNP 558
Cdd:COG5010    81 LQLDPNNPELYYNL-ALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
403-559 1.10e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 64.55  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 403 SNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAicsakrliALAPNLAEGHENLGYALHYSGKPEDALRCFD 482
Cdd:COG4785    26 LAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRA--------LALPDLAQLYYERGVAYDSLGDYDLAIADFD 97
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1223564276 483 RAMALNPYYPDVYLhFQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQ 559
Cdd:COG4785    98 QALELDPDLAEAYN-NRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPN 173
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
379-524 3.48e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 61.90  E-value: 3.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 379 FAPAYAFLAFANILDYANQWSSSWSNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSR--RHEAAICSAKRLIALAPN 456
Cdd:COG5010     7 FDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKlgDFEESLALLEQALQLDPN 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1223564276 457 LAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNP 524
Cdd:COG5010    87 NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNL-AALLLSLGQDDEAKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
439-525 4.27e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.41  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 439 RHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRcFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRR 518
Cdd:COG3063     7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNL-AELLLELGDYDEALAYLER 84

                  ....*..
gi 1223564276 519 RLSRNPS 525
Cdd:COG3063    85 ALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
367-523 1.96e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 367 ELLQRAVEFDPKFAPAYAFLAfaNILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICS 446
Cdd:COG2956   131 EVLERLLKLGPENAHAYCELA--ELYLEQGDY--------DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAA 200
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1223564276 447 AKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLhfQAQAMFQLRRYEEAIGILRRRLSRN 523
Cdd:COG2956   201 LERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLA--LADLLERKEGLEAALALLERQLRRH 275
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
367-489 2.05e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 58.86  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 367 ELLQRAVEFDPKFAPAYAFLAFAnildYANQwssswsNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICS 446
Cdd:COG4235     4 ARLRQALAANPNDAEGWLLLGRA----YLRL------GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEEL 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1223564276 447 AKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP 489
Cdd:COG4235    74 LERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
467-558 2.45e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 57.49  E-value: 2.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 467 ALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGiLRRRLSRNPSTDVSRVLLAASYGHLGRFEEA 546
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNL-GLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEA 78
                          90
                  ....*....|..
gi 1223564276 547 RREWQEVFRVNP 558
Cdd:COG3063    79 LAYLERALELDP 90
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
364-559 4.14e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 62.79  E-value: 4.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 364 KGRELLQRAVEFDPKFAPAYAFLAfaNILDYANQwssswsnaMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAA 443
Cdd:TIGR02917 177 EARALIDEVLTADPGNVDALLLKG--DLLLSLGN--------IELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 444 ICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP-YYPDVYLhfQAQAMFQLRRYEEAIGILRRRLSR 522
Cdd:TIGR02917 247 EKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPeYLPALLL--AGASEYQLGNLEQAYQYLNQILKY 324
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1223564276 523 NPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQ 559
Cdd:TIGR02917 325 APNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPD 361
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
367-549 4.48e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.41  E-value: 4.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 367 ELLQRAVEFDPKFAPAYAFLAfaNILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICS 446
Cdd:COG0457    63 ADYEQALELDPDDAEALNNLG--LALQALGRY--------EEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEA 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 447 AKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRA-MALNPYYPDVYLHFQAQAMFQLRRYEEAIGILRRRLSRNPS 525
Cdd:COG0457   133 YERALELDPDDADALYNLGIALEKLGRYEEALELLEKLeAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLA 212
                         170       180
                  ....*....|....*....|....
gi 1223564276 526 TDVSRVLLAASYGHLGRFEEARRE 549
Cdd:COG0457   213 ILTLAALAELLLLALALLLALRLA 236
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
425-587 5.25e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 5.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 425 YAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMF 504
Cdd:COG2956     9 LGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLEL-AQDYL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 505 QLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPNDFELIVDGL 584
Cdd:COG2956    88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEAL 167

                  ...
gi 1223564276 585 RKA 587
Cdd:COG2956   168 EKA 170
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
424-587 1.51e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.78  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 424 PYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVY-------- 495
Cdd:COG3914     1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAallllaal 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 496 LHFQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPN 575
Cdd:COG3914    81 LELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160
                         170
                  ....*....|..
gi 1223564276 576 DFELIVDGLRKA 587
Cdd:COG3914   161 RLEEAIAALRRA 172
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
407-489 1.97e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 54.79  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 407 AQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAIcSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMA 486
Cdd:COG3063     9 EEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALE 87

                  ...
gi 1223564276 487 LNP 489
Cdd:COG3063    88 LDP 90
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
320-547 2.56e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 60.10  E-value: 2.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 320 ALALNLAKGDQQRLA--TEQTGNLDAYDCFLHGREQLWRFTKAENIKGRELLQRAVEFDPKFApaYAFLAFANILDYANQ 397
Cdd:TIGR02917  97 ARAYLLQGKFQQVLDelPGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSL--YAKLGLAQLALAENR 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 398 wssswsnaMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDA 477
Cdd:TIGR02917 175 --------FDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 478 LRCFDRAMALNPYYPDVyLHFQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEAR 547
Cdd:TIGR02917 247 EKHADALLKKAPNSPLA-HYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAY 315
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
370-548 4.67e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.85  E-value: 4.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 370 QRAVEFDPKFAPAYAFLAfaNILDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKR 449
Cdd:COG4785    63 IDRALALPDLAQLYYERG--VAYDSLGDY--------DLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDR 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 450 LIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYL-HFQAQAmfqLRRYEEAigilRRRLSRNPSTDv 528
Cdd:COG4785   133 ALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALwLYLAER---KLDPEKA----LALLLEDWATA- 204
                         170       180
                  ....*....|....*....|
gi 1223564276 529 srvllaasYGHLGRFEEARR 548
Cdd:COG4785   205 --------YLLQGDTEEARE 216
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
368-489 7.49e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.27  E-value: 7.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 368 LLQRAVEFDPKFAPAYAFLAFANILDYANQWSSSWSNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSA 447
Cdd:COG5010    32 AGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYY 111
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1223564276 448 KRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP 489
Cdd:COG5010   112 EKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
366-506 1.25e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 52.61  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 366 RELLQRAVEFDPKFAPAYAFLAFANIL--DYanqwssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAA 443
Cdd:COG4785    93 IADFDQALELDPDLAEAYNNRGLAYLLlgDY------------DAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELA 160
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1223564276 444 ICSAKRLIALAPNLAEGHENLgYALHYSGKPEDALRcfdramALNPYYPDVYLHF----QAQAMFQL 506
Cdd:COG4785   161 IADLEKALELDPNDPERALWL-YLAERKLDPEKALA------LLLEDWATAYLLQgdteEARELFKL 220
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
194-489 2.74e-07

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 53.32  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 194 TAAPPQLSIAVLPFaNMSGDAEQEyfadGISEDIITALSKLSQLFVIARNSSFTFKGRNV-NVQEVGRNLGVHYVLEGSV 272
Cdd:PRK12370  116 APQPTTHTLAILPF-QMQDQVQSE----SLHYSIVKGLSQYAPFGLSVLPVTITKNCRSVkDILELMDQLRPDYYISGQM 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 273 RKSGNKVRITAQLIDATTGGHLWAERFDRDLTDIFAVqddVTQQIVDALALNLAKGDQQRLATEQTGNLDAYDCFLHGRE 352
Cdd:PRK12370  191 IPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASL---LQNKIANLLLRCIPGLRWDTKQISELNSIDSTMVYLRGKH 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 353 QLWRFTKAENIKGRELLQRAVEFDPKFAPAYAFLAFANiLDYANQWSSSWSNAMAQAEMFAARAVALDDRYPYAhwaLGI 432
Cdd:PRK12370  268 ELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECY-LSMAQMGIFDKQNAMIKAKEHAIKATELDHNNPQA---LGL 343
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 433 VELYSRRHEAAICSA---KRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP 489
Cdd:PRK12370  344 LGLINTIHSEYIVGSllfKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLDP 403
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
364-559 4.51e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.16  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 364 KGRELLQRAVEFDPKFAPAYAFLAFANILdyanqwssswSNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAA 443
Cdd:TIGR02917 381 KAAEYLAKATELDPENAAARTQLGISKLS----------QGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKA 450
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 444 ICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVyLHFQAQAMFQLRRYEEAIGILRRRLSRN 523
Cdd:TIGR02917 451 LAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPA-AANLARIDIQEGNPDDAIQRFEKVLTID 529
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1223564276 524 PSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQ 559
Cdd:TIGR02917 530 PKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQ 565
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
409-560 7.94e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.39  E-value: 7.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 409 AEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALN 488
Cdd:TIGR02917 144 AQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALR 223
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1223564276 489 PYYPDVYLhFQAQAMFQLRRYEEA---IGILRRRLSRNPSTDVSRVLLAASYghlGRFEEARREWQEVFRVNPQY 560
Cdd:TIGR02917 224 PNNIAVLL-ALATILIEAGEFEEAekhADALLKKAPNSPLAHYLKALVDFQK---KNYEDARETLQDALKSAPEY 294
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
354-559 1.05e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.01  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 354 LWRFTKAENIKGRELLQRAVEFDPKFAPAyafLAFANILDYA-NQWSsswsnamaQAEMFAARAVALDDRYPYAHWALGI 432
Cdd:TIGR02917 269 LVDFQKKNYEDARETLQDALKSAPEYLPA---LLLAGASEYQlGNLE--------QAYQYLNQILKYAPNSHQARRLLAS 337
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 433 VELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLhfqAQAMFQLR--RYE 510
Cdd:TIGR02917 338 IQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAART---QLGISKLSqgDPS 414
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1223564276 511 EAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEAR---REWQEVFRVNPQ 559
Cdd:TIGR02917 415 EAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALaaaKKLEKKQPDNAS 466
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
466-553 1.17e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 47.29  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 466 YALHYSGKPEDALRCFDRAMALNP---YYPDVYLhFQAQAMFQLRRYEEAIGILRRRLSRNPST---DVSRVLLAASYGH 539
Cdd:COG1729     1 KALLKAGDYDEAIAAFKAFLKRYPnspLAPDALY-WLGEAYYALGDYDEAAEAFEKLLKRYPDSpkaPDALLKLGLSYLE 79
                          90
                  ....*....|....
gi 1223564276 540 LGRFEEARREWQEV 553
Cdd:COG1729    80 LGDYDKARATLEEL 93
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
475-547 3.52e-06

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 45.32  E-value: 3.52e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1223564276 475 EDALRCFDRAMALNPYYPDvYLHFQAQAMFQLRRYEEAIGILRRRLSRNPSTDvSRVLLAASYGHLGRFEEAR 547
Cdd:pfam12895   6 KNAIFLAERLLAAEPESPE-DAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLG-CRYLFAQCLLKLKKYDEAL 76
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
435-530 5.36e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.75  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 435 LYSRRHEAAICSAKRLIALAPN---LAEGHENLGYALHYSGKPEDALRCFDRAMALNP---YYPDVYLHfQAQAMFQLRR 508
Cdd:COG1729     4 LKAGDYDEAIAAFKAFLKRYPNsplAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPdspKAPDALLK-LGLSYLELGD 82
                          90       100
                  ....*....|....*....|..
gi 1223564276 509 YEEAIGILRRRLSRNPSTDVSR 530
Cdd:COG1729    83 YDKARATLEELIKKYPDSEAAK 104
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
419-559 6.44e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.21  E-value: 6.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 419 LDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHf 498
Cdd:TIGR00990 326 LGEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYH- 404
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1223564276 499 QAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQ 559
Cdd:TIGR00990 405 RAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPE 465
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
357-587 1.77e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 357 FTKAENIKGRELLQRAVEFDPKFAPAYAFLA--------------------------FANILDYANQWSSSWSNAMAQAE 410
Cdd:TIGR02917 476 LGKGDLAKAREAFEKALSIEPDFFPAAANLAridiqegnpddaiqrfekvltidpknLRAILALAGLYLRTGNEEEAVAW 555
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 411 MFAARAVALDDRYPyahwALGIVELYSRRHEA--AICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALN 488
Cdd:TIGR02917 556 LEKAAELNPQEIEP----ALALAQYYLGKGQLkkALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQ 631
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 489 PYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKV 568
Cdd:TIGR02917 632 PDSALALLLL-ADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEG 710
                         250
                  ....*....|....*....
gi 1223564276 569 LPYKDPNDFELIVDGLRKA 587
Cdd:TIGR02917 711 DLYLRQKDYPAAIQAYRKA 729
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
364-558 2.17e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 364 KGRELLQRAVEFDPKFAPAYAFLAFAnildyanqwSSSWSNAmAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAA 443
Cdd:TIGR02917 619 KAVSSFKKLLALQPDSALALLLLADA---------YAVMKNY-AKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESA 688
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 444 ICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPD-VYLHfqaQAMFQLRRYEEAIGILRRRLSR 522
Cdd:TIGR02917 689 KKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNaIKLH---RALLASGNTAEAVKTLEAWLKT 765
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1223564276 523 NPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNP 558
Cdd:TIGR02917 766 HPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAP 801
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
476-559 2.46e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.23  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 476 DALRCFDRAMALNPYYPDVYLhFQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFR 555
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWL-LLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA 79

                  ....
gi 1223564276 556 VNPQ 559
Cdd:COG4235    80 LDPD 83
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
449-587 2.89e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.57  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 449 RLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLHFQAQAMFQLRRYEEAIGILRRRLSRNPSTDV 528
Cdd:COG5010    10 LPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPE 89
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1223564276 529 SRVLLAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPNDFELIVDGLRKA 587
Cdd:COG5010    90 LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRA 148
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
461-560 4.35e-05

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 45.26  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 461 HENLGYALHYSGKPEDALRCFDRAMAlNPYYPDVYLHFQ-AQAMFQLRRYEEAIGILRRRLSRNPSTDVSRV--LLAASY 537
Cdd:COG4700    92 RVRLADALLELGRYDEAIELYEEALT-GIFADDPHILLGlAQALFELGRYAEALETLEKLIAKNPDFKSSDAhlLYARAL 170
                          90       100
                  ....*....|....*....|...
gi 1223564276 538 GHLGRFEEARREWQEVFRVNPQY 560
Cdd:COG4700   171 EALGDLEAAEAELEALARRYSGP 193
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
429-553 4.62e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 429 ALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEdALRCFDRAMALNPYYPDVyLHFQAQAMFQLRR 508
Cdd:TIGR02917 775 ALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDPR-ALEYAERALKLAPNIPAI-LDTLGWLLVEKGE 852
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1223564276 509 YEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEV 553
Cdd:TIGR02917 853 ADRALPLLRKAVNIAPEAAAIRYHLALALLATGRKAEARKELDKL 897
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
366-459 7.80e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 7.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 366 RELLQRAVEFDPKFAPAYAFLAFAniLDYANQWssswsnamAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAIC 445
Cdd:COG4235    37 LAAYEKALRLDPDNADALLDLAEA--LLAAGDT--------EEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106
                          90
                  ....*....|....
gi 1223564276 446 SAKRLIALAPNLAE 459
Cdd:COG4235   107 AWQKLLALLPADAP 120
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
352-459 9.20e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.69  E-value: 9.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 352 EQLWRFTKAEnikgrELLQRAVEFDPKFAPAYAFLAfaNILDYANQWssswsnamAQAEMFAaRAVALDDRYPYAHWALG 431
Cdd:COG3063     3 LKLGDLEEAE-----EYYEKALELDPDNADALNNLG--LLLLEQGRY--------DEAIALE-KALKLDPNNAEALLNLA 66
                          90       100
                  ....*....|....*....|....*...
gi 1223564276 432 IVELYSRRHEAAICSAKRLIALAPNLAE 459
Cdd:COG3063    67 ELLLELGDYDEALAYLERALELDPSALR 94
TPR_1 pfam00515
Tetratricopeptide repeat;
458-491 1.46e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 1.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1223564276 458 AEGHENLGYALHYSGKPEDALRCFDRAMALNPYY 491
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
211-392 1.55e-04

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 44.65  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 211 SGDAEQEYFADGISEDIITALSKLSQlFVIARNSSFTFKGRNVNvqevGRNLGVHYVLEgsVRKSGNKVRITAQLIDATT 290
Cdd:PRK10153  214 NNWSSQLSYADGIGQLLMADLNTVST-FVVHDKTNYNINEPSSS----GKTLGIAFVNQ--RHYRAQQCFLSVELVDNAD 286
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 291 GGHLWAERFDRDLTDIFAVQDDVTQQIVDALALNLAKGDQQRLATEQTGNLDAYDCFLHGReQLWRFTKAENI-KGRELL 369
Cdd:PRK10153  287 GSVMLSKRYFLTNGNQLSVQNDLSNSLSRALNQPWPERMQERLQQGLPHQGAALTLFYQAH-HYLNSGDAKSLnKASDLL 365
                         170       180
                  ....*....|....*....|...
gi 1223564276 370 QRAVEFDPKFAPAYAFLAFANIL 392
Cdd:PRK10153  366 EEILKSEPDFTYAQAEKALADIV 388
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
458-489 1.81e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 39.04  E-value: 1.81e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1223564276 458 AEGHENLGYALHYSGKPEDALRCFDRAMALNP 489
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDP 32
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
369-587 4.00e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 4.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 369 LQRAVEFDPKFAPAYAFLAFANILdyanqwSSSWSNAMAQAEmfaarAVALDDRYPYA--HWALGIVELYSRRHEAAICS 446
Cdd:TIGR02917  79 LRKALSLGYPKNQVLPLLARAYLL------QGKFQQVLDELP-----GKTLLDDEGAAelLALRGLAYLGLGQLELAQKS 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 447 AKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYLhFQAQAMFQLRRYEEAIGILRRRLSRNPST 526
Cdd:TIGR02917 148 YEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALL-LKGDLLLSLGNIELALAAYRKAIALRPNN 226
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1223564276 527 DVSRVLLAASYGHLGRFEEARREWQEVFRVNPQYSLEHRRKVLPYKDPNDFELIVDGLRKA 587
Cdd:TIGR02917 227 IAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDA 287
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
339-513 5.43e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 43.05  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 339 GNLDAYDCFLHGREQLWRFTKAENIKGRELLQRAVEFDPKFAPAYAFLAFANiLDYanqwssswsNAMAQAEMFAARAVA 418
Cdd:TIGR00990 324 GKLGEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDPRVTQSYIKRASMN-LEL---------GDPDKAEEDFDKALK 393
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 419 LDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNPYYPDVYlHF 498
Cdd:TIGR00990 394 LNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVY-NY 472
                         170
                  ....*....|....*
gi 1223564276 499 QAQAMFQLRRYEEAI 513
Cdd:TIGR00990 473 YGELLLDQNKFDEAI 487
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
458-489 1.09e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1223564276  458 AEGHENLGYALHYSGKPEDALRCFDRAMALNP 489
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
TPR_19 pfam14559
Tetratricopeptide repeat;
471-535 1.32e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.56  E-value: 1.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1223564276 471 SGKPEDALRCFDRAMALNPYYPDVYLHFqAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAA 535
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGL-AEALLALGRLDEAEALLAALPAADPDDPRYAALLAK 64
FlgO pfam17680
FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio ...
185-291 2.12e-03

FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.


Pssm-ID: 435970  Cd Length: 130  Bit Score: 38.64  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 185 HELSEALLSTAAPPQL--SIAVLPFANMSGDAEQEYFADGISEDIITALS---------KLSQLFVIARNSSFTFKgRNV 253
Cdd:pfam17680   1 YQLADQLLANLDPLLLrrPIAVTSFVDLDDLQQTSTLGRQLSESLITELQqrgysvveyKLTDSIRVTEEGEFALS-RDL 79
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1223564276 254 nvQEVGRNLGVHYVLEGSVRKSGNKVRITAQLIDATTG 291
Cdd:pfam17680  80 --RELAETQNADYVLVGTYTVTRDGVLVNARLIDLKDN 115
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
501-559 2.43e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.05  E-value: 2.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1223564276 501 QAMFQLRRYEEAIGILRRRLSRNPS---TDVSRVLLAASYGHLGRFEEARREWQEVFRVNPQ 559
Cdd:COG1729     1 KALLKAGDYDEAIAAFKAFLKRYPNsplAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPD 62
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
441-524 2.97e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 441 EAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFDRAMALNP-YYPDVYLHfqaqaMFQL-------RRYEEA 512
Cdd:cd24142    17 ELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPdGGYEKYLY-----LGQLsggeealQYYEKG 91
                          90
                  ....*....|..
gi 1223564276 513 IGILRRRLSRNP 524
Cdd:cd24142    92 IEILEEELQALQ 103
TPR_12 pfam13424
Tetratricopeptide repeat;
457-525 3.02e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.60  E-value: 3.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1223564276 457 LAEGHENLGYALHYSGKPEDALRCFDRAMAL-----NPYYPDV--YLHFQAQAMFQLRRYEEAIGILRRRLSRNPS 525
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIarrllGPDHPLTatTLLNLGRLYLELGRYEEALELLERALALAEK 77
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
367-456 3.60e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 367 ELLQRAVEFDPKFAPAYAFLAFAnildYANQwssswsNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICS 446
Cdd:COG4783    59 VLLHEALELDPDEPEARLNLGLA----LLKA------GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAA 128
                          90
                  ....*....|
gi 1223564276 447 AKRLIALAPN 456
Cdd:COG4783   129 LEKALELDPD 138
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
403-558 8.05e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 8.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1223564276 403 SNAMAQAEMFAARAVALDDRYPYAHWALGIVELYSRRHEAAICSAKRLIALAPNLAEGHENLGYALHYSGKPEDALRCFD 482
Cdd:TIGR02917 580 KGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLK 659
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1223564276 483 RAMALNPYYPDVYLhFQAQAMFQLRRYEEAIGILRRRLSRNPSTDVSRVLLAASYGHLGRFEEARREWQEVFRVNP 558
Cdd:TIGR02917 660 RALELKPDNTEAQI-GLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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