|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-466 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 607.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 1 MVKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMIS 76
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKElgrpVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 77 GaGFDVVTGDKIIVRGNPEElSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVN 156
Cdd:COG0469 81 G-PVELKKGDTFTLTTDDVE-GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:COG0469 159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLPPDAEIDFKRINNV--VTSVLAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPVYA 394
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPErtITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1224411926 395 MCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGS-FGHSNGATFMEISKV 466
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVpVGVPGTTNTLKVHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-457 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 584.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 1 MVKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMIS 76
Cdd:PRK05826 2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKlgrpVAILLDLKGPKIRVGKFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 77 GAGFdVVTGDKIIVRGNPEELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVN 156
Cdd:PRK05826 82 GKIT-LKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSP-IRLIAKIENQEGVDNIEEILDHAYG 235
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 236 IMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGE 315
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 316 YPEEAVTVMSTVADEIESQlpPDAEIDFKRIN---NVVTSVLAKSAVKATCLLP-IKAVVVDTLSGRTGRYLAAYRGLIP 391
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKE--FSINLSKHRLDrqfDRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGAP 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1224411926 392 VYAMCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNG 457
Cdd:PRK05826 399 IFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-463 |
4.76e-175 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 499.50 E-value: 4.76e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVS----NKIAILVDTKGPEIRTTQmISGA 78
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAeklgRPVAILLDTKGPEIRTGE-IKGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 GFDVVTGDK-IIVRGNPEELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVNI 157
Cdd:TIGR01064 80 EVKLKKGDKvIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 158 PGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSP-IRLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNIDEIAEASDGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLPPDAEI-DFKRINNVVTSV---LAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPV 392
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFnDRKNSDPKPSTIteaIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1224411926 393 YAMCYKEHVMRHLALSYGVQAFYMEPRL-TKDEFVREAMRTLLEQNKVQLDDLVLVV-GGSFGHSNGATFMEI 463
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVDEEPsDTDARVNKALELLKEKGIVKKGDLVVVIqGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
3-466 |
6.17e-158 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 456.39 E-value: 6.17e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMISGA 78
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKtggpVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 GFDVVTGDKIIVRGNP-EELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADS-LVCEVKNHGTIKGRKSVN 156
Cdd:cd00288 82 DISLKAGDKFLVTTDPaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:cd00288 242 MVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLPPDAEID-----FKRINNVVTSVlAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIP 391
Cdd:cd00288 322 PVEAVKAMARICLEAEKALSHRVLFNemrrlTPRPTSTTEAV-AMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 392 VYAMCYKEHVMRHLALSYGVQAF-YMEPRLT----KDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNGATFMEISKV 466
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVlFEEPKPGwqedTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
3-336 |
2.12e-133 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 389.03 E-value: 2.12e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMISGA 78
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKtggtVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 -GFDVVTGDKIIVRGNPE--ELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADS-LVCEVKNHGTIKGRKS 154
Cdd:pfam00224 82 kDIELKAGDEMIVSTDAKykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 155 VNIPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAY 234
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 235 GIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYG 314
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321
|
330 340
....*....|....*....|..
gi 1224411926 315 EYPEEAVTVMSTVADEIESQLP 336
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALP 343
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-466 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 607.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 1 MVKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMIS 76
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKElgrpVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 77 GaGFDVVTGDKIIVRGNPEElSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVN 156
Cdd:COG0469 81 G-PVELKKGDTFTLTTDDVE-GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:COG0469 159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLPPDAEIDFKRINNV--VTSVLAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPVYA 394
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPErtITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1224411926 395 MCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGS-FGHSNGATFMEISKV 466
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVpVGVPGTTNTLKVHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-457 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 584.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 1 MVKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMIS 76
Cdd:PRK05826 2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKlgrpVAILLDLKGPKIRVGKFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 77 GAGFdVVTGDKIIVRGNPEELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVN 156
Cdd:PRK05826 82 GKIT-LKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSP-IRLIAKIENQEGVDNIEEILDHAYG 235
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 236 IMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGE 315
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 316 YPEEAVTVMSTVADEIESQlpPDAEIDFKRIN---NVVTSVLAKSAVKATCLLP-IKAVVVDTLSGRTGRYLAAYRGLIP 391
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKE--FSINLSKHRLDrqfDRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGAP 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1224411926 392 VYAMCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNG 457
Cdd:PRK05826 399 IFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-463 |
4.76e-175 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 499.50 E-value: 4.76e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVS----NKIAILVDTKGPEIRTTQmISGA 78
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAeklgRPVAILLDTKGPEIRTGE-IKGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 GFDVVTGDK-IIVRGNPEELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVNI 157
Cdd:TIGR01064 80 EVKLKKGDKvIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 158 PGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSP-IRLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNIDEIAEASDGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLPPDAEI-DFKRINNVVTSV---LAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPV 392
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFnDRKNSDPKPSTIteaIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1224411926 393 YAMCYKEHVMRHLALSYGVQAFYMEPRL-TKDEFVREAMRTLLEQNKVQLDDLVLVV-GGSFGHSNGATFMEI 463
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVDEEPsDTDARVNKALELLKEKGIVKKGDLVVVIqGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
3-466 |
6.17e-158 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 456.39 E-value: 6.17e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMISGA 78
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKtggpVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 GFDVVTGDKIIVRGNP-EELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADS-LVCEVKNHGTIKGRKSVN 156
Cdd:cd00288 82 DISLKAGDKFLVTTDPaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:cd00288 242 MVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLPPDAEID-----FKRINNVVTSVlAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIP 391
Cdd:cd00288 322 PVEAVKAMARICLEAEKALSHRVLFNemrrlTPRPTSTTEAV-AMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 392 VYAMCYKEHVMRHLALSYGVQAF-YMEPRLT----KDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNGATFMEISKV 466
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVlFEEPKPGwqedTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-474 |
9.42e-142 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 418.95 E-value: 9.42e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 1 MVKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMIS 76
Cdd:PRK06354 6 LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKlgktVGILQDLQGPKIRLGRFED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 77 GAgFDVVTGDKII-----VRGNPEELSsreclyLSYENVVADVHVGASLLIDDGDIGMEV--ISKSADSLVCEVKNHGTI 149
Cdd:PRK06354 86 GP-IELKTGDEFIltsreVLGTQEKFS------VTYDGLADEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 150 KGRKSVNIPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERK-SPIRLIAKIENQEGVDNIEE 228
Cdd:PRK06354 159 SNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNgKHIPIIAKIEKQEAIDNIDA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 229 ILDHAYGIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLS 308
Cdd:PRK06354 239 ILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 309 GETAYGEYPEEAVTVMSTVADEIESQLpPDAEIDFKRINNVVTSVLAKS-AVKATCL-LPIKAVVVDTLSGRTGRYLAAY 386
Cdd:PRK06354 319 NETAAGDYPVEAVQTMATIAVRIEKDL-PYRDILSKRPEFTTTITNAISqAVSHIALqLDAAAIVTLTKSGATARNVSKY 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 387 RGLIPVYAMCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNGAT-FMEISK 465
Cdd:PRK06354 398 RPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTdLMKVHV 477
|
....*....
gi 1224411926 466 VSSMLHFGQ 474
Cdd:PRK06354 478 VGAVVAKGQ 486
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
3-451 |
3.35e-141 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 413.30 E-value: 3.35e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMISGA 78
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKtgkkAAILLDTKGPEIRTMKLEGGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 GFDVVTGDKIIVRGNPEELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVNIP 158
Cdd:PRK09206 82 DVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 159 GVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERK-SPIRLIAKIENQEGVDNIEEILDHAYGIM 237
Cdd:PRK09206 162 GVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgENIQIISKIENQEGLNNFDEILEASDGIM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 238 VARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEYP 317
Cdd:PRK09206 242 VARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 318 EEAVTVMSTVADEIESQLPPdaEIDFKRINNV--VTSVLAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPVYAM 395
Cdd:PRK09206 322 LEAVSIMATICERTDRVMNS--RLESNNDNRKlrITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILAL 399
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1224411926 396 CYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGS 451
Cdd:PRK09206 400 TTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGA 455
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
3-336 |
2.12e-133 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 389.03 E-value: 2.12e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMISGA 78
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKtggtVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 -GFDVVTGDKIIVRGNPE--ELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADS-LVCEVKNHGTIKGRKS 154
Cdd:pfam00224 82 kDIELKAGDEMIVSTDAKykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 155 VNIPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAY 234
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 235 GIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYG 314
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321
|
330 340
....*....|....*....|..
gi 1224411926 315 EYPEEAVTVMSTVADEIESQLP 336
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALP 343
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
1-461 |
1.10e-128 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 381.58 E-value: 1.10e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 1 MVKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMIS 76
Cdd:PRK06247 3 RNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDEtgrpIGILADLQGPKLRLGRFAD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 77 GAgFDVVTGDKIIVRGNPEELSSREcLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVN 156
Cdd:PRK06247 83 GK-VQLANGQTFRLDVDDAPGDHDR-VSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSpirLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVP---VMAKIEKPQAIDRLEAIVEASDAI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:PRK06247 238 MVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLPPDAEIDFKRINNVVTS--VLAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPVYA 394
Cdd:PRK06247 318 PVEAVRTMARIIRQVERDPTYPPLIHAQRPQPEATKrdAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILA 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1224411926 395 MCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNGATFM 461
Cdd:PRK06247 398 LTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNM 464
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
3-466 |
4.15e-112 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 340.59 E-value: 4.15e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKV-----SNKIAILVDTKGPEIRTTQMISG 77
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAakarpNANLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 78 AGFDVVTGDKIIVRGNPEELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVNI 157
Cdd:PTZ00066 118 KPITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 158 PGVSISLPSLSEKDINFI-HFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAYGI 236
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 237 MVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEY 316
Cdd:PTZ00066 278 MVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKF 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 317 PEEAVTVMSTVADEIESQLppDAEIDFKRINNVVTS------VLAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLI 390
Cdd:PTZ00066 358 PVEAVNIMAKICFEAETCI--DYRVLYHAIHLAVPTpvsvqeAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSC 435
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1224411926 391 PVYAMCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNGAT-FMEISKV 466
Cdd:PTZ00066 436 TILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSnLMKVVKI 512
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-399 |
5.69e-112 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 340.03 E-value: 5.69e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 2 VKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNKI----AILVDTKGPEIRTTQMISG 77
Cdd:PLN02461 20 RPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTgilcAVMLDTKGPEIRTGFLKDG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 78 AGFDVVTGDKIIVRGNPEELSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVIS--KSADSLVCEVKNHGTIKGRKSV 155
Cdd:PLN02461 100 KPVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGERKNV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 156 NIPGVSISLPSLSEKDIN-FIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAY 234
Cdd:PLN02461 180 NLPGVVVDLPTLTEKDKEdILQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 235 GIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYG 314
Cdd:PLN02461 260 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 315 EYPEEAVTVMSTVADEIESQLppDAEIDFKRINNVVTS------VLAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRG 388
Cdd:PLN02461 340 AYPELAVKTMARICREAEASL--DYGALFKEIMRSAPLpmspleSLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRP 417
|
410
....*....|.
gi 1224411926 389 LIPVYAMCYKE 399
Cdd:PLN02461 418 AVPILSVVVPE 428
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
29-448 |
1.83e-100 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 308.52 E-value: 1.83e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 29 MNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMISGaGFDVVTGDKIIVRGNP--EELSSREC 102
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAElgvnIAIALDTKGPEIRTGLFVGG-EAVMERGATCYVTTDPafADKGTKDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 103 LYLSYENVVADVHVGASLLIDDGDIGMEVISKSAD-SLVCEVKNHGTIKGRKSVNIPGVSISLPSLSEKDINFIHFAIDQ 181
Cdd:PTZ00300 80 FYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 182 KIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILDHAYGIMVARGDLGIEIPAEKIPVIQRRLIR 261
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILIS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 262 KCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEYPEEAVTVMSTVAdeIESQLPPDAEI 341
Cdd:PTZ00300 240 KCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARIC--LEAQSAVNEYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 342 DFKRINNV------VTSVLAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPVYAMCYKEHVMRHLALSYGVQA-F 414
Cdd:PTZ00300 318 FFNSIKKLqpipmsAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESvF 397
|
410 420 430
....*....|....*....|....*....|....*...
gi 1224411926 415 YMEPRLTKDEFVREAMRTLLEQNK----VQLDDLVLVV 448
Cdd:PTZ00300 398 FDAERLGHDEGKEQRVAMGVGFAKskgyVQSGDLMVVV 435
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
3-448 |
4.01e-98 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 306.47 E-value: 4.01e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAH---QSPSDSIKLIE--NVRKVSNKIAILVDTKGPEIRT---TQM 74
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHgdhASHQKVIDLVKeyNAQSKDNVIAIMLDTKGPEVRSgdlPQP 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 75 I---SGAGFDVVtgdkiIVRGnpeeLSSRECLYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKG 151
Cdd:PLN02623 190 ImleEGQEFTFT-----IKRG----VSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKS 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 152 RKSVNIPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSPIRLIAKIENQEGVDNIEEILD 231
Cdd:PLN02623 261 RRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIIT 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 232 HAYGIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGET 311
Cdd:PLN02623 341 ASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGET 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 312 AYGEYPEEAVTVMSTVADEIESQL-----PPDAEIDFKrinNVVTSVLAKSAVKATCLLPiKAVVVDTLSGRTGRYLAAY 386
Cdd:PLN02623 421 AHGKFPLKAVKVMHTVALRTEATLpegttPPNLGQAFK---NHMSEMFAFHATMMANTLG-TSIIVFTRTGFMAILLSHY 496
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1224411926 387 RGLIPVYAMCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVV 448
Cdd:PLN02623 497 RPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALV 558
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
2-448 |
6.28e-80 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 257.37 E-value: 6.28e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 2 VKRTKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNK----IAILVDTKGPEIRTTQMISG 77
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEkgfaVAVMMDTEGSEIHMGDLGGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 78 AGFDVVTGDKIIVRGNPEELSSREC-LYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVN 156
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRKFDGSRPEFtIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANLT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 157 -------IPGVSISLPSLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDER--KSPIRLIAKIENQEGVDNIE 227
Cdd:PLN02762 184 fwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARsrDSDIGVIAKIESLDSLKNLE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 228 EILDHAYGIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIML 307
Cdd:PLN02762 264 EIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALML 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 308 SGETAYGEYPEEAVTVMSTVADEIESQ-----------LPPDAEIDFKRINNVVTSvlakSAVKATCLLPIKAVVVDTLS 376
Cdd:PLN02762 344 SGESAMGLYPEKALSVLRSVSLRMELWsreekrhealeLPQLSSSLSDRISEEICN----SAAKMANNLGVDAIFVYTKH 419
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1224411926 377 GRTGRYLAAYRGLIPVYAMCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTLLEQNKVQLDDLVLVV 448
Cdd:PLN02762 420 GHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAV 491
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
13-332 |
1.41e-79 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 251.40 E-value: 1.41e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 13 DRRCEV-------EFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSNKIAILVDTKGPEIRTTQmISGAGFDVVTG 85
Cdd:PRK06739 4 DRICTIgpasnnkETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDSIKILGDVQGPKIRLGE-IKGEQITLQAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 86 DKIIVRGNPEELSSREClYLSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEVKNHGTIKGRKSVNIPGVSISLP 165
Cdd:PRK06739 83 DSFILHTQPVTGSSTEA-SVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 166 SLSEKDINFIHFAIDQKIDFIAHSFVRRKEDLIGIQQILDERK--SPiRLIAKIENQEGVDNIEEILDHAYGIMVARGDL 243
Cdd:PRK06739 162 AITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKetSP-NLIAKIETMEAIENFQDICKEADGIMIARGDL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 244 GIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEYPEEAVTV 323
Cdd:PRK06739 241 GVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVST 320
|
....*....
gi 1224411926 324 MSTVADEIE 332
Cdd:PRK06739 321 LRLVSEFAE 329
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
5-394 |
1.01e-66 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 223.01 E-value: 1.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 5 TKIVATISDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKV--SNKI--AILVDTKGPEIrttQMI--SGA 78
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAvkNTKKlcAVMLDTVGPEL---QVInkTEK 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 79 GFDVVTGDKIIVRGNPEELSSRECLYLSYENVVADVHVGASLLI--------DDGDIGMEVISKSADSLVCEVKNHGTIK 150
Cdd:PLN02765 107 PISLKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVKNSATLA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 151 GRK-SVNIPGVSISLPSLSEKDINFI-HFAIDQKIDFIAHSFVRRKEDLIGIQQILDERKSP-IRLIAKIENQEGVDNIE 227
Cdd:PLN02765 187 GSLfTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSqTQIFAKIENVEGLTHFD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 228 EILDHAYGIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIaTQMLHTMITNPRPTRAEVSDIANAIYQRTDAIML 307
Cdd:PLN02765 267 EILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 308 SGETAYGEYPEEAVTVMSTVADEIESQLppDAEIDFKRINNVV------TSVLAKSAVKATCLLPIKAVVVDTLSGRTGR 381
Cdd:PLN02765 346 GAETLRGLYPVETISTVGRICAEAEKVF--NQDLYFKKTVKYVgepmshLESIASSAVRAAIKVKASVIIVFTSSGRAAR 423
|
410
....*....|...
gi 1224411926 382 YLAAYRGLIPVYA 394
Cdd:PLN02765 424 LIAKYRPTMPVLS 436
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
3-327 |
1.47e-55 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 192.54 E-value: 1.47e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 3 KRTKIVATI-SDRRCEVEFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVS----NKIAILVDTKGPEIRTTQMISG 77
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAEratgRRCKILMDLAGPKIRTGAVAGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 78 AGFD-VVTGDKI-IVRGNPEELSSRECLY--LSYENVVADVHVGASLLIDDGDIGMEVISKSADSLVCEV---KNHGT-I 149
Cdd:PRK08187 213 LGKTrLYTGDRLaLVAQGPPRRIDEEHFQvtCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVthaRPKGLkL 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 150 KGRKSVNIPGVSISLPSLSEKDINFIHFAIDQKiDFIAHSFVRRKEDLIGIQQILDERK----SPIRLIAKIENQEGVDN 225
Cdd:PRK08187 293 KPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRpddwRKLGLVLKIETPRAVAN 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 226 IEEILDHA-----YGIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAiyQ 300
Cdd:PRK08187 372 LPELIVQAagrqpFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--A 449
|
330 340
....*....|....*....|....*..
gi 1224411926 301 RTDAIMLSGetayGEYPEEAVTVMSTV 327
Cdd:PRK08187 450 RAECVMLNK----GPYLVEAVTFLDDL 472
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
19-327 |
5.99e-39 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 148.94 E-value: 5.99e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 19 EFLQRLYNEGMNVVRLNTAHQSPSDSIKLIENVRKVSN----KIAILVDTKGPEIRT----------------------- 71
Cdd:PRK14725 156 DLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEelgrRCRIAMDLAGPKLRTgpiapgprviklrptrdalgrvl 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 72 ----------------------TQMISGAGFDVV-TGDKIIV---RG--------------------------------- 92
Cdd:PRK14725 236 tparlwltasespppspppgpvGLPVDPEWLARLePGDELRFtdaRGkkrkltvtevddegvlaegsqtaylangtllrl 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 93 ---------------NPEELSSRECLYLSYE---------------------NVVADVHVGASLLIDDGDIGMEVISKSA 136
Cdd:PRK14725 316 grhdstrvgglppveQKLRLKVGDRLVLTRDdapgdpaqgdapparisctlpEAFRAARVGERVWFDDGKIGAVVVKVEA 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 137 DSLVCEVKNHG----TIKGRKSVNIPGVSISLPSLSEKDINFIHFAIDQkIDFIAHSFVRRKEDLIGIQQILDERK-SPI 211
Cdd:PRK14725 396 DEVELRITHARpggsKLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDALEKLGaDDL 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 212 RLIAKIENQEGVDNIEEIL-----DHAYGIMVARGDLGIEIPAEKIPVIQRRLIRKCTESKKPVIIATQMLHTMITNPRP 286
Cdd:PRK14725 475 GVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLP 554
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1224411926 287 TRAEVSDIANAiyQRTDAIMLSGetayGEYPEEAVTVMSTV 327
Cdd:PRK14725 555 SRAEITDAAMA--LRAECVMLNK----GPHIVEAVRVLDDI 589
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
262-461 |
1.33e-32 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 126.17 E-value: 1.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 262 KCTESKKPVIIATQMLHTMITNPRPTRAEVSDIANAIYQRTDAIMLSGETAYGEYPEEAVTVMSTVADEIESQLPPDAEI 341
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 342 DFKRINNVVTSVLAKSAvkATC----LLPIKAVVVDTLSGRTGRYLAAYRGLIPVYAMCYKEHVMRHLALSYGVQAFYME 417
Cdd:COG3848 81 VPRAKESSTTITDAISH--AVAttaaDLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVE 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1224411926 418 PRLTKDEFVREAMRTLLEQNKVQLDDLVLVVGGSFGHSNGATFM 461
Cdd:COG3848 159 ESASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNL 202
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
354-459 |
5.88e-24 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 96.40 E-value: 5.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224411926 354 LAKSAVKATCLLPIKAVVVDTLSGRTGRYLAAYRGLIPVYAMCYKEHVMRHLALSYGVQAFYMEPRLTKDEFVREAMRTL 433
Cdd:pfam02887 3 IAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKVA 82
|
90 100
....*....|....*....|....*.
gi 1224411926 434 LEQNKVQLDDLVLVVGGSFGHSNGAT 459
Cdd:pfam02887 83 KEAGLVKKGDLVVITAGVPFGVSGTT 108
|
|
| |
