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Conserved domains on  [gi|1224755772|ref|WP_092773560|]
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transcriptional regulator [Agrobacterium fabrum]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 11467951)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-102 2.10e-34

Predicted transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 120.84  E-value: 2.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224755772   7 LVDAEKEFDVLKAAASLIRVQILKLLHgANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATC 86
Cdd:COG4189     3 VLDDEESLEVLKALASETRLRILRLLA-EEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYLRV 81

                          90
                  ....*....|....*.
gi 1224755772  87 DELIVSFRKPETPAAS 102
Cdd:COG4189    82 DKILIVLPGLDESDRE 97
 
Name Accession Description Interval E-value
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-102 2.10e-34

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 120.84  E-value: 2.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224755772   7 LVDAEKEFDVLKAAASLIRVQILKLLHgANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATC 86
Cdd:COG4189     3 VLDDEESLEVLKALASETRLRILRLLA-EEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYLRV 81

                          90
                  ....*....|....*.
gi 1224755772  87 DELIVSFRKPETPAAS 102
Cdd:COG4189    82 DKILIVLPGLDESDRE 97
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 15-75 3.13e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 60.94  E-value: 3.13e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1224755772  15 DVLKAAASLIRVQILKLLHgANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTEtRKAR 75
Cdd:NF033788    3 ELFKALADPTRLRILELLA-EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR-REGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-76 5.15e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 60.39  E-value: 5.15e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224755772  17 LKAAASLIRVQILKLLHGaNGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARK 76
Cdd:cd00090     1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRV 59
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-73 6.29e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 54.08  E-value: 6.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1224755772  15 DVLKAAASLIRVQILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRK 73
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-76 1.77e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 47.59  E-value: 1.77e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1224755772   27 QILKLLHGaNGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTEtRKARK 76
Cdd:smart00418   1 KILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESR-REGKR 48
 
Name Accession Description Interval E-value
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-102 2.10e-34

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 120.84  E-value: 2.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224755772   7 LVDAEKEFDVLKAAASLIRVQILKLLHgANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATC 86
Cdd:COG4189     3 VLDDEESLEVLKALASETRLRILRLLA-EEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYLRV 81

                          90
                  ....*....|....*.
gi 1224755772  87 DELIVSFRKPETPAAS 102
Cdd:COG4189    82 DKILIVLPGLDESDRE 97
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 15-75 3.13e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 60.94  E-value: 3.13e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1224755772  15 DVLKAAASLIRVQILKLLHgANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTEtRKAR 75
Cdd:NF033788    3 ELFKALADPTRLRILELLA-EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR-REGR 61
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-89 3.54e-12

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 61.44  E-value: 3.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224755772   1 MAPNFLLVDAEkefDVLKAAASLIRVQILKLLHgANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTEtrkaRKGSQK 80
Cdd:COG0640     1 MSETKELEELA---ELFKALADPTRLRILRLLA-EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSR----REGRWV 72


                  ....*....
gi 1224755772  81 ICFATCDEL 89
Cdd:COG0640    73 YYRLADEAL 81
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-76 5.15e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 60.39  E-value: 5.15e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224755772  17 LKAAASLIRVQILKLLHGaNGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARK 76
Cdd:cd00090     1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRV 59
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-73 6.29e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 54.08  E-value: 6.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1224755772  15 DVLKAAASLIRVQILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRK 73
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-76 1.77e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 47.59  E-value: 1.77e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1224755772   27 QILKLLHGaNGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTEtRKARK 76
Cdd:smart00418   1 KILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESR-REGKR 48
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
15-101 2.06e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 48.88  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224755772  15 DVLKAAASLIRVQILKLLHGANGlNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATCDELIVSFR 94
Cdd:COG1777     9 RLLDALGNPTRRRILALLSEEPA-YVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLSAFRLEVTL 87


                  ....*..
gi 1224755772  95 KPETPAA 101
Cdd:COG1777    88 TPDLFAR 94
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 22-70 3.97e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.43  E-value: 3.97e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1224755772  22 SLIRVQILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTE 70
Cdd:pfam12802   4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
HTH_IclR pfam09339
IclR helix-turn-helix domain;
22-70 1.08e-05

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 42.01  E-value: 1.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1224755772  22 SLIR-VQILKLL-HGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTE 70
Cdd:pfam09339   1 SLDRaLAILDALaEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQD 51
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
22-71 1.64e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 43.81  E-value: 1.64e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1224755772  22 SLIRVQILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTET 71
Cdd:COG1846    37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 25-67 3.06e-05

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 40.50  E-value: 3.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1224755772  25 RVQILKLLhgANG-LNVNEIAQRLALPQSTVSAGVAVLEEAGLL 67
Cdd:pfam01022   4 RLKILKLL--AEGeLCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
24-67 1.71e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.57  E-value: 1.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1224755772  24 IRVQILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLL 67
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
22-75 2.32e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 41.73  E-value: 2.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1224755772  22 SLIR-VQILKLL-HGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKAR 75
Cdd:COG1414     7 SLERaLAILEALaEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGR 62
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
25-77 4.77e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.68  E-value: 4.77e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1224755772  25 RVQILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKG 77
Cdd:COG2345    15 RRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRG 67
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
18-70 5.06e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.86  E-value: 5.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1224755772  18 KAAASLIR----VQILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTE 70
Cdd:COG3398    88 KKILAYLRretpRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERE 144
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
26-77 6.75e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 39.18  E-value: 6.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1224755772  26 VQILKLLHGA-NGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKG 77
Cdd:COG3355    30 AEVYLILLENgEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLEGG 82
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-68 8.69e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.96  E-value: 8.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1224755772   28 ILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLR 68
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVR 55
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
22-75 1.78e-03

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 36.79  E-value: 1.78e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1224755772   22 SLIR-VQILKLL-HGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKAR 75
Cdd:smart00346   3 SLERgLAVLRALaEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGR 58
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
11-73 1.94e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.88  E-value: 1.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1224755772  11 EKEFDVLKAaaslirvqILKLLHGANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRK 73
Cdd:COG1321     6 ESEEDYLKA--------IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYG 60
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
27-68 3.69e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 37.07  E-value: 3.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1224755772  27 QILKLLHgANG-LNVNEIAQRLALPQSTVSAGVAVLEEAGLLR 68
Cdd:COG1522     9 RILRLLQ-EDGrLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 27-76 3.81e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 35.66  E-value: 3.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1224755772  27 QILKLLHGANG-LNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTEtRKARK 76
Cdd:COG2512    19 RVLELLRENGGrMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE-RVGRE 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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