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Conserved domains on  [gi|1225034777|ref|WP_093048854|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [unclassified Variovorax]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 15841257)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355
SCOP:  4000333|3000001|3000086

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 85-193 1.25e-22

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


:

Pssm-ID: 465574  Cd Length: 114  Bit Score: 88.00  E-value: 1.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  85 EQRLRRFIYRIVEEYAGAQDAHRVLTDDVRFLAEADRERVLDKEREVVAGFARAVSALRP-GAPSDDLAKPLTMLLFGMI 163
Cdd:pfam17932   5 VERLRALVRAHVRVHAERRDEAAVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAaGEFRDLDPKLAALAILGML 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1225034777 164 NWMFTWMKPGGRLDHAAIAPIVADLFLGGI 193
Cdd:pfam17932  85 NWVYRWYRPDGPLSPEEIADQYADLLLRGL 114
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-62 5.82e-11

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 55.49  E-value: 5.82e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1225034777  16 ILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISI 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 85-193 1.25e-22

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 88.00  E-value: 1.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  85 EQRLRRFIYRIVEEYAGAQDAHRVLTDDVRFLAEADRERVLDKEREVVAGFARAVSALRP-GAPSDDLAKPLTMLLFGMI 163
Cdd:pfam17932   5 VERLRALVRAHVRVHAERRDEAAVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAaGEFRDLDPKLAALAILGML 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1225034777 164 NWMFTWMKPGGRLDHAAIAPIVADLFLGGI 193
Cdd:pfam17932  85 NWVYRWYRPDGPLSPEEIADQYADLLLRGL 114
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-164 1.60e-19

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 81.48  E-value: 1.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  13 RELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISIAETHVSKLAALVaEEEASTHTDEQRLRRFI 92
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAL-EEALAAEDPRERLRALL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1225034777  93 YRIVEEYAGAQDAHRVLTDDVRFLAEAdRERVLDKEREVVAGFARAVsaLRPGAPSDDLAKPLTMLLFGMIN 164
Cdd:COG1309    87 RAYLEFLAENPALARLLLAEAAELPEL-RAALRALLRRLRALLAELL--RAGGLLADVDPDALARALLALLD 155
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-62 5.82e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 55.49  E-value: 5.82e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1225034777  16 ILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISI 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
13-162 3.86e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 54.14  E-value: 3.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  13 RELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISIAETHVSKLAALVAEEEASTHTDEQRLRRFI 92
Cdd:NF041196    8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGGSKLQELVDLT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  93 YRIveeyagaqdAHRVLTDDV----------RFLAEADRERVLDKEREVVAGF---ARAVSALRPGAPSDDLAKPLTMLL 159
Cdd:NF041196   88 HVL---------ARRLRTDPVvragvrlsieQAAIGAGLPTPYREWIDLVAELlaeARAAGELLPGVDPEEAARLLVGAF 158


                  ...
gi 1225034777 160 FGM 162
Cdd:NF041196  159 TGV 161
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 13-125 4.22e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.85  E-value: 4.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  13 RELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISIAETHVSKLAALVAEEEA------------- 79
Cdd:PRK10668   13 RQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGELELEYQAkfpddplsvlrei 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1225034777  80 ------STHTDEQR--LRRFIY---RIVEEYAGAQDAHRVLtddvrFLAEADR-ERVL 125
Cdd:PRK10668   93 liyileATVTDERRrlLMEIIFhkcEFVGEMAVVQQAQRNL-----CLESYDRiEQTL 145
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 5-62 6.45e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 45.30  E-value: 6.45e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1225034777   5 RSATYDDQRELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISI 62
Cdd:PRK15008   12 RSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAV 69
 
Name Accession Description Interval E-value
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 85-193 1.25e-22

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 88.00  E-value: 1.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  85 EQRLRRFIYRIVEEYAGAQDAHRVLTDDVRFLAEADRERVLDKEREVVAGFARAVSALRP-GAPSDDLAKPLTMLLFGMI 163
Cdd:pfam17932   5 VERLRALVRAHVRVHAERRDEAAVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAaGEFRDLDPKLAALAILGML 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1225034777 164 NWMFTWMKPGGRLDHAAIAPIVADLFLGGI 193
Cdd:pfam17932  85 NWVYRWYRPDGPLSPEEIADQYADLLLRGL 114
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-164 1.60e-19

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 81.48  E-value: 1.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  13 RELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISIAETHVSKLAALVaEEEASTHTDEQRLRRFI 92
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAL-EEALAAEDPRERLRALL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1225034777  93 YRIVEEYAGAQDAHRVLTDDVRFLAEAdRERVLDKEREVVAGFARAVsaLRPGAPSDDLAKPLTMLLFGMIN 164
Cdd:COG1309    87 RAYLEFLAENPALARLLLAEAAELPEL-RAALRALLRRLRALLAELL--RAGGLLADVDPDALARALLALLD 155
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-62 5.82e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 55.49  E-value: 5.82e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1225034777  16 ILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISI 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
4-188 2.69e-09

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 54.56  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777   4 GRSATYDDQRELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISIAETHVSKLAALVAEEEASTHT 83
Cdd:COG3226     1 PRRRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  84 DEQRLRRFIyRIVEEYAGAQDAHRVLTDDVRFLAEADRE--RVLDKEREVVAGFARAVSALRPGAPSDDLAKPLTMLLFG 161
Cdd:COG3226    81 LEDAAEALA-DLLAELLPADRDRLLARYELYLEALRDPElrALLRRWRDRLREALARLLAALGSPDPPETARALVALIDG 159

                         170       180
                  ....*....|....*....|....*..
gi 1225034777 162 MinwMFTWMKPGGRLDHAAIAPIVADL 188
Cdd:COG3226   160 L---TLHALLDPDPLTREELRAALRRL 183
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
13-162 3.86e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 54.14  E-value: 3.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  13 RELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISIAETHVSKLAALVAEEEASTHTDEQRLRRFI 92
Cdd:NF041196    8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGGSKLQELVDLT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  93 YRIveeyagaqdAHRVLTDDV----------RFLAEADRERVLDKEREVVAGF---ARAVSALRPGAPSDDLAKPLTMLL 159
Cdd:NF041196   88 HVL---------ARRLRTDPVvragvrlsieQAAIGAGLPTPYREWIDLVAELlaeARAAGELLPGVDPEEAARLLVGAF 158


                  ...
gi 1225034777 160 FGM 162
Cdd:NF041196  159 TGV 161
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 13-125 4.22e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.85  E-value: 4.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225034777  13 RELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISIAETHVSKLAALVAEEEA------------- 79
Cdd:PRK10668   13 RQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGELELEYQAkfpddplsvlrei 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1225034777  80 ------STHTDEQR--LRRFIY---RIVEEYAGAQDAHRVLtddvrFLAEADR-ERVL 125
Cdd:PRK10668   93 liyileATVTDERRrlLMEIIFhkcEFVGEMAVVQQAQRNL-----CLESYDRiEQTL 145
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 5-62 6.45e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 45.30  E-value: 6.45e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1225034777   5 RSATYDDQRELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLLISI 62
Cdd:PRK15008   12 RSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAV 69
PRK11640 PRK11640
putative transcriptional regulator; Provisional
 12-59 4.89e-03

putative transcriptional regulator; Provisional


Pssm-ID: 183252 [Multi-domain]  Cd Length: 191  Bit Score: 36.51  E-value: 4.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1225034777  12 QRELILAQAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDKSSLL 59
Cdd:PRK11640    2 QREDVLGEALKLLEQQGLANTTLEMLAERVDYPLDELQRFWPDREALL 49
HTH_Tnp_1_2 pfam13022
Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins ...
 19-55 7.42e-03

Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins which are likely to be a helix-turn-helix insertion elements.


Pssm-ID: 404044 [Multi-domain]  Cd Length: 122  Bit Score: 35.17  E-value: 7.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1225034777  19 QAAQLFARSGYPATSMNQVAEACGLSKATLYHYYKDK 55
Cdd:pfam13022  13 KAAELLAENDYHTLTKDEIAEELGVSRSTLYKWLRKK 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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