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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Variovorax]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-146 2.49e-51

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 160.33  E-value: 2.49e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810   4 LDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTethkr 83
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR----- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1225045810  84 npMDLFRASVQTWPEVVECAALTGDMDYLLRVVVADMAHYSRFIMDTLLKHPSVEDCKTSFVL 146
Cdd:COG1522    78 --LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-146 2.49e-51

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 160.33  E-value: 2.49e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810   4 LDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTethkr 83
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR----- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1225045810  84 npMDLFRASVQTWPEVVECAALTGDMDYLLRVVVADMAHYSRFIMDTLLKHPSVEDCKTSFVL 146
Cdd:COG1522    78 --LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
2-155 1.24e-34

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 118.71  E-value: 1.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810   2 EALDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTEth 81
Cdd:PRK11169   10 KDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAP-- 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1225045810  82 krNPMDLFRASVQTWPEVVECAALTGDMDYLLRVVVADMAHYSRFIMDTLLKHPSVEDCKTSFVLDRVKATTAV 155
Cdd:PRK11169   88 --DVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-117 1.31e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 109.14  E-value: 1.31e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810    4 LDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTETHKr 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEE- 79

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1225045810   84 npmdlFRASVQTWPEVVECAALTGDMDYLLRVVV 117
Cdd:smart00344  80 -----FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 79-148 2.42e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 79.11  E-value: 2.42e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810  79 ETHKRNPMDLFRASVQTWPEVVECAALTGDMDYLLRVVVADMAHYSRFIMDTLLKHPSVEDCKTSFVLDR 148
Cdd:pfam01037   4 KLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-53 3.91e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 45.37  E-value: 3.91e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1225045810   5 DKIDRMILRTLqADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRY 53
Cdd:cd00090     6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-146 2.49e-51

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 160.33  E-value: 2.49e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810   4 LDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTethkr 83
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR----- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1225045810  84 npMDLFRASVQTWPEVVECAALTGDMDYLLRVVVADMAHYSRFIMDTLLKHPSVEDCKTSFVL 146
Cdd:COG1522    78 --LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
2-155 1.24e-34

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 118.71  E-value: 1.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810   2 EALDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTEth 81
Cdd:PRK11169   10 KDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAP-- 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1225045810  82 krNPMDLFRASVQTWPEVVECAALTGDMDYLLRVVVADMAHYSRFIMDTLLKHPSVEDCKTSFVLDRVKATTAV 155
Cdd:PRK11169   88 --DVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-117 1.31e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 109.14  E-value: 1.31e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810    4 LDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTETHKr 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEE- 79

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1225045810   84 npmdlFRASVQTWPEVVECAALTGDMDYLLRVVV 117
Cdd:smart00344  80 -----FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 79-148 2.42e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 79.11  E-value: 2.42e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810  79 ETHKRNPMDLFRASVQTWPEVVECAALTGDMDYLLRVVVADMAHYSRFIMDTLLKHPSVEDCKTSFVLDR 148
Cdd:pfam01037   4 KLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
5-45 9.60e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 63.93  E-value: 9.60e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1225045810   5 DKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLE 45
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-50 6.97e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 62.07  E-value: 6.97e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1225045810   6 KIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVI 50
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-53 3.91e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 45.37  E-value: 3.91e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1225045810   5 DKIDRMILRTLqADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRY 53
Cdd:cd00090     6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 4-127 1.13e-06

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 45.47  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225045810   4 LDKIDRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRYVALVQPEAIGLGLTAYLNVRLEKHTETHKR 83
Cdd:PRK11179    7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAKDYPSA 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1225045810  84 npmdlfRASVQTWPEVVECAALTGdmdyllrvvvadmaHYSRFI 127
Cdd:PRK11179   87 ------LAKLESLDEVVEAYYTTG--------------HYSIFI 110
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 2-53 5.09e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 39.51  E-value: 5.09e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1225045810   2 EALDKIDRMILRTL-QADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRY 53
Cdd:COG2512    11 PELLEDERRVLELLrENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE 63
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
8-52 2.80e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.09  E-value: 2.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1225045810   8 DRMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDR 52
Cdd:COG3398    99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVER 143
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
11-53 2.92e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 39.49  E-value: 2.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1225045810  11 ILRTLqADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRY 53
Cdd:COG4742    21 ILLLL-AEGPKTRSELAESLDVSRSTILRQLKELEERGLIERD 62
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
10-53 9.98e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.42  E-value: 9.98e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1225045810   10 MILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRY 53
Cdd:smart00347  14 LVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRRE 57
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 10-53 1.59e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.22  E-value: 1.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1225045810  10 MILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRY 53
Cdd:pfam01047   7 HILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERS 50
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
11-53 1.66e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 1.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1225045810   11 ILRTLqADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDRY 53
Cdd:smart00418   2 ILKLL-AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
9-52 1.69e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.21  E-value: 1.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1225045810   9 RMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVIDR 52
Cdd:COG2345    16 RRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVER 59
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 9-51 6.62e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 33.28  E-value: 6.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1225045810   9 RMILRTLQADGRATYDQIAEQVSLSPSAVLRRVKRLEEHRVID 51
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVE 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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