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Conserved domains on  [gi|1226979238|ref|WP_094000400|]
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MULTISPECIES: methyltransferase domain-containing protein [unclassified Stenotrophomonas]

Protein Classification

methyltransferase domain-containing protein( domain architecture ID 1004954)

methyltransferase domain-containing protein may be a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK08317 super family cl32293
hypothetical protein; Provisional
 33-267 2.74e-28

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PRK08317:

Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 108.49  E-value: 2.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  33 IFGQIDYSGARRLLEVGSGVGAQTEILLRRF-PELHVTGVDLSETQLATARE-NLARTPWCSdrytLQQADAGELPFEAR 110
Cdd:PRK08317   11 TFELLAVQPGDRVLDVGCGPGNDARELARRVgPEGRVVGIDRSEAMLALAKErAAGLGPNVE----FVRGDADGLPFPDG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238 111 SFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDPYSPHIWRywmAFNDFQYDHGGDPFVGAKLGNL 190
Cdd:PRK08317   87 SFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDWDTLVWHSGDRALMR---KILNFWSDHFADPWLGRRLPGL 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1226979238 191 LLAGGFRDVHTEIKTIHLDNREPARRKTMiafweqlLLSAADQLLQAGAVDEDTVEGMRREFRlvQNDPNAVFFYSF 267
Cdd:PRK08317  164 FREAGLTDIEVEPYTLIETDLKEADKGFG-------LIRAARRAVEAGGISADEADAWLADLA--QLARAGEFFFSV 231
 
Name Accession Description Interval E-value
PRK08317 PRK08317
hypothetical protein; Provisional
 33-267 2.74e-28

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 108.49  E-value: 2.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  33 IFGQIDYSGARRLLEVGSGVGAQTEILLRRF-PELHVTGVDLSETQLATARE-NLARTPWCSdrytLQQADAGELPFEAR 110
Cdd:PRK08317   11 TFELLAVQPGDRVLDVGCGPGNDARELARRVgPEGRVVGIDRSEAMLALAKErAAGLGPNVE----FVRGDADGLPFPDG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238 111 SFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDPYSPHIWRywmAFNDFQYDHGGDPFVGAKLGNL 190
Cdd:PRK08317   87 SFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDWDTLVWHSGDRALMR---KILNFWSDHFADPWLGRRLPGL 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1226979238 191 LLAGGFRDVHTEIKTIHLDNREPARRKTMiafweqlLLSAADQLLQAGAVDEDTVEGMRREFRlvQNDPNAVFFYSF 267
Cdd:PRK08317  164 FREAGLTDIEVEPYTLIETDLKEADKGFG-------LIRAARRAVEAGGISADEADAWLADLA--QLARAGEFFFSV 231
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 33-148 2.06e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 103.15  E-value: 2.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  33 IFGQIDYSGARRLLEVGSGVGAQTEILLRRfpELHVTGVDLSETQLATARENLARTPWcsdRYTLQQADAGELPFEARSF 112
Cdd:COG2226    14 LLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL---NVEFVVGDAEDLPFPDGSF 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1226979238 113 DSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITE 148
Cdd:COG2226    89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVD 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 46-146 7.62e-27

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 100.05  E-value: 7.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  46 LEVGSGVGAQTEILLRRFPelHVTGVDLSETQLATARENLARtpwcsDRYTLQQADAGELPFEARSFDSAFLCWVLEHVP 125
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKAPR-----EGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVE 73

                          90       100
                  ....*....|....*....|.
gi 1226979238 126 SPARVLSEVRRVLAPGSPVYI 146
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 44-141 7.51e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 71.69  E-value: 7.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  44 RLLEVGSGVGAQTeILLRRFPELHVTGVDLSETQLATARENLARtpWCSDRYTLQQADAGELPFEA-RSFDSAFLCWVLE 122
Cdd:cd02440     1 RVLDLGCGTGALA-LALASGPGARVTGVDISPVALELARKAAAA--LLADNVEVLKGDAEELPPEAdESFDVIISDPPLH 77

                          90       100
                  ....*....|....*....|
gi 1226979238 123 H-VPSPARVLSEVRRVLAPG 141
Cdd:cd02440    78 HlVEDLARFLEEARRLLKPG 97
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 43-163 7.42e-14

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 68.83  E-value: 7.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  43 RRLLEVGSGVGAQTEILLRRFPE-LHVTGVDLSETQLATARENLARtpwcSDRYTLQQADAGELPFEARSFDSAFLCWVL 121
Cdd:TIGR01934  41 QKVLDVACGTGDLAIELAKSAPDrGKVTGVDFSSEMLEVAKKKSEL----PLNIEFIQADAEALPFEDNSFDAVTIAFGL 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1226979238 122 EHVPSPARVLSEVRRVLAPGSPVYITEVMN-ASFLLDP----YSPHI 163
Cdd:TIGR01934 117 RNVTDIQKALREMYRVLKPGGRLVILEFSKpANALLKKfykfYLKNV 163
 
Name Accession Description Interval E-value
PRK08317 PRK08317
hypothetical protein; Provisional
 33-267 2.74e-28

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 108.49  E-value: 2.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  33 IFGQIDYSGARRLLEVGSGVGAQTEILLRRF-PELHVTGVDLSETQLATARE-NLARTPWCSdrytLQQADAGELPFEAR 110
Cdd:PRK08317   11 TFELLAVQPGDRVLDVGCGPGNDARELARRVgPEGRVVGIDRSEAMLALAKErAAGLGPNVE----FVRGDADGLPFPDG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238 111 SFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDPYSPHIWRywmAFNDFQYDHGGDPFVGAKLGNL 190
Cdd:PRK08317   87 SFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDWDTLVWHSGDRALMR---KILNFWSDHFADPWLGRRLPGL 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1226979238 191 LLAGGFRDVHTEIKTIHLDNREPARRKTMiafweqlLLSAADQLLQAGAVDEDTVEGMRREFRlvQNDPNAVFFYSF 267
Cdd:PRK08317  164 FREAGLTDIEVEPYTLIETDLKEADKGFG-------LIRAARRAVEAGGISADEADAWLADLA--QLARAGEFFFSV 231
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 33-148 2.06e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 103.15  E-value: 2.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  33 IFGQIDYSGARRLLEVGSGVGAQTEILLRRfpELHVTGVDLSETQLATARENLARTPWcsdRYTLQQADAGELPFEARSF 112
Cdd:COG2226    14 LLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL---NVEFVVGDAEDLPFPDGSF 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1226979238 113 DSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITE 148
Cdd:COG2226    89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVD 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 46-146 7.62e-27

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 100.05  E-value: 7.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  46 LEVGSGVGAQTEILLRRFPelHVTGVDLSETQLATARENLARtpwcsDRYTLQQADAGELPFEARSFDSAFLCWVLEHVP 125
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKAPR-----EGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVE 73

                          90       100
                  ....*....|....*....|.
gi 1226979238 126 SPARVLSEVRRVLAPGSPVYI 146
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-141 1.38e-25

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 96.86  E-value: 1.38e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  46 LEVGSGVGAQTEILLRRFpELHVTGVDLSETQLATARENLARTPWcsdRYTLQQADAGELPFEARSFDSAFLCWVLEHVP 125
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL---NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLP 77

                          90
                  ....*....|....*...
gi 1226979238 126 SP--ARVLSEVRRVLAPG 141
Cdd:pfam13649  78 DPdlEAALREIARVLKPG 95
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 43-147 3.70e-23

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 91.62  E-value: 3.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  43 RRLLEVGSGVGAQTEILLRRFpeLHVTGVDLSETQLATARENLARTpwcsdRYTLQQADAGELPFEARSFDSAFLCWVLE 122
Cdd:COG2227    26 GRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIARERAAEL-----NVDFVQGDLEDLPLEDGSFDLVICSEVLE 98

                          90       100
                  ....*....|....*....|....*
gi 1226979238 123 HVPSPARVLSEVRRVLAPGSPVYIT 147
Cdd:COG2227    99 HLPDPAALLRELARLLKPGGLLLLS 123
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
41-141 5.76e-21

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 84.88  E-value: 5.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  41 GARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLARTpwcsdryTLQQADAGELPFEaRSFDSAFLCWV 120
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNV-------RFVVADLRDLDPP-EPFDLVVSNAA 72

                          90       100
                  ....*....|....*....|.
gi 1226979238 121 LEHVPSPARVLSEVRRVLAPG 141
Cdd:COG4106    73 LHWLPDHAALLARLAAALAPG 93
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 46-141 5.19e-18

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 77.02  E-value: 5.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  46 LEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLARTPW-CSDRYTLQQADAGELPFEarSFDSAFLCWVLEHV 124
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLlNAVRVELFQLDLGELDPG--SFDVVVASNVLHHL 78

                          90
                  ....*....|....*..
gi 1226979238 125 PSPARVLSEVRRVLAPG 141
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPG 95
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 25-141 4.41e-16

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 73.43  E-value: 4.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  25 QARLLESsIFGQIDYSGARRLLEVGSGVGAQTEILLRRFpELHVTGVDLSETQLATARENLARTPwCSDRYTLQQADAGE 104
Cdd:COG2230    36 QEAKLDL-ILRKLGLKPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAG-LADRVEVRLADYRD 112

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1226979238 105 LPFEARsFDSAFLCWVLEHVPSP--ARVLSEVRRVLAPG 141
Cdd:COG2230   113 LPADGQ-FDAIVSIGMFEHVGPEnyPAYFAKVARLLKPG 150
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 44-141 7.51e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 71.69  E-value: 7.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  44 RLLEVGSGVGAQTeILLRRFPELHVTGVDLSETQLATARENLARtpWCSDRYTLQQADAGELPFEA-RSFDSAFLCWVLE 122
Cdd:cd02440     1 RVLDLGCGTGALA-LALASGPGARVTGVDISPVALELARKAAAA--LLADNVEVLKGDAEELPPEAdESFDVIISDPPLH 77

                          90       100
                  ....*....|....*....|
gi 1226979238 123 H-VPSPARVLSEVRRVLAPG 141
Cdd:cd02440    78 HlVEDLARFLEEARRLLKPG 97
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 44-158 3.45e-15

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 70.91  E-value: 3.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  44 RLLEVGSGVGAQTEILLRRF-PELHVTGVDLSETQLATARENLARTPwcSDRYTLQQADAGELP--FEARSFDSAFLCWV 120
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEKARENAQKLG--FDNVEFEQGDIEELPelLEDDKFDVVISNCV 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1226979238 121 LEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDP 158
Cdd:pfam13847  84 LNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAH 121
PLN02244 PLN02244
tocopherol O-methyltransferase
 25-147 7.17e-15

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 73.24  E-value: 7.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  25 QARLLESSI-FGQI---DYSGARRLLEVGSGVGAQTEILLRRFpELHVTGVDLSETQLATAREnLARTPWCSDRYTLQQA 100
Cdd:PLN02244   98 QIRMIEESLaWAGVpddDEKRPKRIVDVGCGIGGSSRYLARKY-GANVKGITLSPVQAARANA-LAAAQGLSDKVSFQVA 175

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1226979238 101 DAGELPFEARSFDsafLCWVLE---HVPSPARVLSEVRRVLAPGSPVYIT 147
Cdd:PLN02244  176 DALNQPFEDGQFD---LVWSMEsgeHMPDKRKFVQELARVAAPGGRIIIV 222
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 41-147 7.31e-15

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 71.10  E-value: 7.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  41 GARRLLEVGSGVGAQTEILLRRFPElHVTGVDLSETQLATARENLARTPwcSDRYTLQQADAGEL-PFEARSFDSAFLCW 119
Cdd:COG0500    26 KGGRVLDLGCGTGRNLLALAARFGG-RVIGIDLSPEAIALARARAAKAG--LGNVEFLVADLAELdPLPAESFDLVVAFG 102

                          90       100       110
                  ....*....|....*....|....*....|
gi 1226979238 120 VLEHVPSPAR--VLSEVRRVLAPGSPVYIT 147
Cdd:COG0500   103 VLHHLPPEEReaLLRELARALKPGGVLLLS 132
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
41-141 9.24e-15

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 70.41  E-value: 9.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  41 GARRLLEVGSGVGAQTEILLRRFpeLHVTGVDLSETQLATARENLARTpwcsdryTLQQADAGELPFEARSFDSAFLCWV 120
Cdd:COG4976    46 PFGRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAREKGVYD-------RLLVADLADLAEPDGRFDLIVAADV 116

                          90       100
                  ....*....|....*....|.
gi 1226979238 121 LEHVPSPARVLSEVRRVLAPG 141
Cdd:COG4976   117 LTYLGDLAAVFAGVARALKPG 137
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 43-163 7.42e-14

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 68.83  E-value: 7.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  43 RRLLEVGSGVGAQTEILLRRFPE-LHVTGVDLSETQLATARENLARtpwcSDRYTLQQADAGELPFEARSFDSAFLCWVL 121
Cdd:TIGR01934  41 QKVLDVACGTGDLAIELAKSAPDrGKVTGVDFSSEMLEVAKKKSEL----PLNIEFIQADAEALPFEDNSFDAVTIAFGL 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1226979238 122 EHVPSPARVLSEVRRVLAPGSPVYITEVMN-ASFLLDP----YSPHI 163
Cdd:TIGR01934 117 RNVTDIQKALREMYRVLKPGGRLVILEFSKpANALLKKfykfYLKNV 163
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 37-148 2.28e-12

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 64.79  E-value: 2.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  37 IDYSGAR---RLLEVGSGVGAQTEILLRRFPEL-HVTGVDLSETQLATARENLaRTPWCSDRYTLQQADAGELPFEARSF 112
Cdd:PRK00216   44 IKWLGVRpgdKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGMLAVGREKL-RDLGLSGNVEFVQGDAEALPFPDNSF 122

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1226979238 113 DSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITE 148
Cdd:PRK00216  123 DAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILE 158
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 42-113 6.34e-11

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 60.93  E-value: 6.34e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1226979238  42 ARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLARTPWcSDRYTLQQADAGELP--FEARSFD 113
Cdd:COG4123    38 GGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGL-EDRITVIHGDLKEFAaeLPPGSFD 110
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 43-200 5.87e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 56.67  E-value: 5.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  43 RRLLEVGSGVGAQTEILLRRFPElhVTGVDLSETQLATARENLARtpwcsdrytlQQADAGELPFEARSFDSAfLCW-VL 121
Cdd:pfam13489  24 GRVLDFGCGTGIFLRLLRAQGFS--VTGVDPSPIAIERALLNVRF----------DQFDEQEAAVPAGKFDVI-VAReVL 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1226979238 122 EHVPSPARVLSEVRRVLAPGSPVYITEVmNASFLLDPYSPHiWRYWMafndFQYDHgGDPFVGAKLGNLLLAGGFRDVH 200
Cdd:pfam13489  91 EHVPDPPALLRQIAALLKPGGLLLLSTP-LASDEADRLLLE-WPYLR----PRNGH-ISLFSARSLKRLLEEAGFEVVS 162
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 39-144 1.04e-08

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 54.40  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  39 YSGARrLLEVGSGVGAQTEILLRRF-PELHVTGVDLSETQLATARENLARTpWCSDRYTLQQADAGElPFEARSFDSAFL 117
Cdd:COG2519    90 FPGAR-VLEAGTGSGALTLALARAVgPEGKVYSYERREDFAEIARKNLERF-GLPDNVELKLGDIRE-GIDEGDVDAVFL 166

                          90       100
                  ....*....|....*....|....*..
gi 1226979238 118 cwvleHVPSPARVLSEVRRVLAPGSPV 144
Cdd:COG2519   167 -----DMPDPWEALEAVAKALKPGGVL 188
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
37-148 3.14e-07

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 50.13  E-value: 3.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  37 IDYSGARR---LLEVGSGVGAQTEILLRRF-PELHVTGVDLSETQLATARENLARTPWCSDRYTlqQADAGELPFEARSF 112
Cdd:pfam01209  35 MKCMGVKRgnkFLDVAGGTGDWTFGLSDSAgSSGKVVGLDINENMLKEGEKKAKEEGKYNIEFL--QGNAEELPFEDDSF 112

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1226979238 113 DSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITE 148
Cdd:pfam01209 113 DIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLE 148
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 36-141 4.10e-07

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 49.94  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  36 QIDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLartPWCsdryTLQQAD-AGELPFEARS--F 112
Cdd:PRK01683   26 RVPLENPRYVVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARSRL---PDC----QFVEADiASWQPPQALDliF 98

                          90       100
                  ....*....|....*....|....*....
gi 1226979238 113 DSAFLCWVLEHVPSPARVLSevrrVLAPG 141
Cdd:PRK01683   99 ANASLQWLPDHLELFPRLVS----LLAPG 123
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 33-113 5.17e-07

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 49.76  E-value: 5.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  33 IFGQIDYSGARRLLEVGSGVGAqteI---LLRRFPELHVTGVDLSETQLATARENLARTPwCSDRYTLQQADAGELPFEA 109
Cdd:COG2890   104 ALALLPAGAPPRVLDLGTGSGA---IalaLAKERPDARVTAVDISPDALAVARRNAERLG-LEDRVRFLQGDLFEPLPGD 179


                  ....
gi 1226979238 110 RSFD 113
Cdd:COG2890   180 GRFD 183
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 44-170 2.02e-06

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 48.35  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  44 RLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLARTPwCsdryTLQQADAGELPFEARSFDSAFLCWVLEH 123
Cdd:PLN02490  116 KVVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAKQKEPLKE-C----KIIEGDAEDLPFPTDYADRYVSAGSIEY 190

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1226979238 124 VPSPARVLSEVRRVLAPGSpvyitevmnASFLLDPYSPHIW--RY----WMAF 170
Cdd:PLN02490  191 WPDPQRGIKEAYRVLKIGG---------KACLIGPVHPTFWlsRFfadvWMLF 234
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 68-146 1.47e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 45.27  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  68 VTGVDLSETQLATA--RENLaRTPWCSDRYTLQQADAGELPFEARSFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVY 145
Cdd:PLN02233  101 VMGLDFSSEQLAVAasRQEL-KAKSCYKNIEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVS 179


                  .
gi 1226979238 146 I 146
Cdd:PLN02233  180 I 180
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 40-117 1.48e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 44.40  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  40 SGARRLLEVGSGVGAQTEILLRRFPEL-HVTGVDLSETQLATARENLARTPWcSDRYTLQQADAGE-LP-FEARSFDSAF 116
Cdd:COG4122    15 LGAKRILEIGTGTGYSTLWLARALPDDgRLTTIEIDPERAAIARENFARAGL-ADRIRLILGDALEvLPrLADGPFDLVF 93


                  .
gi 1226979238 117 L 117
Cdd:COG4122    94 I 94
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 44-164 2.39e-05

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 45.11  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  44 RLLEVGSGVGAQTEILLRRFPElhVTGVDLSETQLATARENLARTPWCSD-RYTLQQADagELPFEARSFDSAFLCWVLE 122
Cdd:PLN02396  134 KFIDIGCGGGLLSEPLARMGAT--VTGVDAVDKNVKIARLHADMDPVTSTiEYLCTTAE--KLADEGRKFDAVLSLEVIE 209

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1226979238 123 HVPSPARVLSEVRRVLAPGSPV-----------YITEVMNASFLLD--PYSPHIW 164
Cdd:PLN02396  210 HVANPAEFCKSLSALTIPNGATvlstinrtmraYASTIVGAEYILRwlPKGTHQW 264
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 70-148 2.76e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 43.52  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  70 GVDLSETQLATA--RENL-ARTpwCSDRYTLQQADAGELPFEARSFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYI 146
Cdd:PLN02232    2 GLDFSSEQLAVAatRQSLkARS--CYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSI 79


                  ..
gi 1226979238 147 TE 148
Cdd:PLN02232   80 LD 81
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 36-113 2.97e-05

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 44.38  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  36 QIDYSGARRLLEVGSGVGAqteI---LLRRFPELHVTGVDLSETQLATARENLARTPwcSDRYTLQQADAGElPFEARSF 112
Cdd:PRK09328  103 ALLLKEPLRVLDLGTGSGA---IalaLAKERPDAEVTAVDISPEALAVARRNAKHGL--GARVEFLQGDWFE-PLPGGRF 176


                  .
gi 1226979238 113 D 113
Cdd:PRK09328  177 D 177
arsM PRK11873
arsenite methyltransferase;
46-149 4.07e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.17  E-value: 4.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  46 LEVGSGVGAQTEILLRRF-PELHVTGVDLSETQLATARENLARTPWcsDRYTLQQADAGELPFEARSFDSAFLCWVLEHV 124
Cdd:PRK11873   82 LDLGSGGGFDCFLAARRVgPTGKVIGVDMTPEMLAKARANARKAGY--TNVEFRLGEIEALPVADNSVDVIISNCVINLS 159

                          90       100
                  ....*....|....*....|....*
gi 1226979238 125 PSPARVLSEVRRVLAPGSPVYITEV 149
Cdd:PRK11873  160 PDKERVFKEAFRVLKPGGRFAISDV 184
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
105-185 7.33e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 42.16  E-value: 7.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238 105 LPFEARSFDSAFLCWVLEHVPSPA--RVLSEVRRVLAPGSPVYITeVMNASFLLDPYSPHI--------WRYWMAFNDFQ 174
Cdd:COG4627    40 LPFPDNSVDAIYSSHVLEHLDYEEapLALKECYRVLKPGGILRIV-VPDLEHVARLYLAEYdaaldvaeLRLAGPIDPLG 118

                          90
                  ....*....|.
gi 1226979238 175 YDHGGDPFVGA 185
Cdd:COG4627   119 IILGERLAGLA 129
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 67-172 1.96e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 41.67  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  67 HVTGVDLSETQLATARENLArtpwcSDRYtlQQADAGELPFEARSFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYI 146
Cdd:PRK10258   66 QVTALDLSPPMLAQARQKDA-----ADHY--LAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAF 138

                          90       100
                  ....*....|....*....|....*.
gi 1226979238 147 TEVMNASFlldpysPHIWRYWMAFND 172
Cdd:PRK10258  139 TTLVQGSL------PELHQAWQAVDE 158
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 28-113 2.54e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.94  E-value: 2.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  28 LLEssifgQIDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLARTpwCSDRYTLQQADAGElPF 107
Cdd:COG2813    41 LLE-----HLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAAN--GLENVEVLWSDGLS-GV 112


                  ....*.
gi 1226979238 108 EARSFD 113
Cdd:COG2813   113 PDGSFD 118
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 67-117 2.69e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 41.71  E-value: 2.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1226979238  67 HVTGVDLSETQLATARENLARTPwCSDRYTLQQADA----GELPFEARSFDSAFL 117
Cdd:COG1092   241 SVTSVDLSATALEWAKENAALNG-LDDRHEFVQADAfdwlRELAREGERFDLIIL 294
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 42-87 3.57e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 40.27  E-value: 3.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1226979238  42 ARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLAR 87
Cdd:pfam05175  32 SGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAA 77
PRK06202 PRK06202
hypothetical protein; Provisional
 40-139 7.81e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 39.98  E-value: 7.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  40 SGARRLLEVGSGvGAQTEILLRRFPE-----LHVTGVDLSETQLATARENlARTPwcsdRYTLQQADAGELPFEARSFDS 114
Cdd:PRK06202   59 DRPLTLLDIGCG-GGDLAIDLARWARrdglrLEVTAIDPDPRAVAFARAN-PRRP----GVTFRQAVSDELVAEGERFDV 132

                          90       100
                  ....*....|....*....|....*
gi 1226979238 115 AFLCWVLEHVPSParvlsEVRRVLA 139
Cdd:PRK06202  133 VTSNHFLHHLDDA-----EVVRLLA 152
PRK06922 PRK06922
class I SAM-dependent methyltransferase;
37-146 1.38e-03

class I SAM-dependent methyltransferase;


Pssm-ID: 180751 [Multi-domain]  Cd Length: 677  Bit Score: 39.85  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  37 IDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLAT--ARENLARTPWcsdryTLQQADAGELP--FEARSF 112
Cdd:PRK06922  414 LDYIKGDTIVDVGAGGGVMLDMIEEETEDKRIYGIDISENVIDTlkKKKQNEGRSW-----NVIKGDAINLSssFEKESV 488

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1226979238 113 D----SAFLCWVLEHVPSP---------ARVLSEVRRVLAPGSPVYI 146
Cdd:PRK06922  489 DtivySSILHELFSYIEYEgkkfnheviKKGLQSAYEVLKPGGRIII 535
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 66-144 1.45e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 38.39  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  66 LHVTGVDLSETQLATARENLARTpwCSDRYTLQQADAGELPFEARSFDSAFLcwvleHVP----------SP----ARVL 131
Cdd:COG1041    49 RRVIGSDIDPKMVEGARENLEHY--GYEDADVIRGDARDLPLADESVDAIVT-----DPPygrsskisgeELlelyEKAL 121

                          90
                  ....*....|...
gi 1226979238 132 SEVRRVLAPGSPV 144
Cdd:COG1041   122 EEAARVLKPGGRV 134
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
41-87 1.89e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 38.44  E-value: 1.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1226979238  41 GARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLAR 87
Cdd:PRK08287   31 RAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQR 77
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 42-83 2.99e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 38.13  E-value: 2.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1226979238  42 ARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARE 83
Cdd:PRK14103   30 ARRVVDLGCGPGNLTRYLARRWPGAVIEALDSSPEMVAAARE 71
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 23-87 7.02e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 36.60  E-value: 7.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1226979238  23 MTQARLLEssifgQIDYSGARRLLEVGSGVGAQTEILLRRFPelHVTGVDLSETQLATARENLAR 87
Cdd:COG2518    53 YIVARMLE-----ALDLKPGDRVLEIGTGSGYQAAVLARLAG--RVYSVERDPELAERARERLAA 110
methyltran_NanM TIGR04371
putative sugar O-methyltransferase; Members of this family appear to be SAM-dependent ...
 35-126 8.37e-03

putative sugar O-methyltransferase; Members of this family appear to be SAM-dependent O-methyltransferases acting on sugars, based on iterated sequence searches and gene context. Members occur in Leptospira O-antigen regions, as well NanM from the biosynthesis cluster for nanchangmycin, which produces 4-O-methyl-L-rhodinose as an intermediate. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 275164  Cd Length: 273  Bit Score: 37.01  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226979238  35 GQIDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSEtQLATARENLARTPWCSDRYTLQQADAGELPFEARSFDS 114
Cdd:TIGR04371 143 KFFGDLSVFRVLEIGGGYGRLGEILLKLFPNAIYYIVDLPP-QLALSEAYLSEVFPEEKVVLYAQTRKQENIDLPDDGRI 221

                          90
                  ....*....|...
gi 1226979238 115 AFLC-WVLEHVPS 126
Cdd:TIGR04371 222 YFLPpWQLPLLGN 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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