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Conserved domains on  [gi|1236168408|ref|WP_094961302|]
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MULTISPECIES: GNAT family N-acetyltransferase [Providencia]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
52-148 2.57e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.40  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  52 VDDEPVGFVQYYSNHENGRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLGkyksVSICYVEGNDIMKPFFEQFGF 131
Cdd:COG3153    46 DDGEIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERG----ARAVVLLGDPSLLPFYERFGF 121

                          90
                  ....*....|....*..
gi 1236168408 132 SVVEQDEFDETIMRLFF 148
Cdd:COG3153   122 RPAGELGLTLGPDEVFL 138
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
52-148 2.57e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.40  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  52 VDDEPVGFVQYYSNHENGRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLGkyksVSICYVEGNDIMKPFFEQFGF 131
Cdd:COG3153    46 DDGEIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERG----ARAVVLLGDPSLLPFYERFGF 121

                          90
                  ....*....|....*..
gi 1236168408 132 SVVEQDEFDETIMRLFF 148
Cdd:COG3153   122 RPAGELGLTLGPDEVFL 138
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 50-131 1.10e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.21  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  50 IYVDDEPVGFVQYYSNHEngRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLGkYKSVSICYVEGNDIMKPFFEQF 129
Cdd:pfam00583  38 AEEDGELVGFASLSIIDD--EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERG-CERIFLEVAADNLAAIALYEKL 114


                  ..
gi 1236168408 130 GF 131
Cdd:pfam00583 115 GF 116
PRK09831 PRK09831
GNAT family N-acetyltransferase;
52-136 2.19e-06

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 44.56  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  52 VDDEPVGFVQYYSNHengrpeevfIDQLMIDIKHQRKGFGSKAI-PLVleeiknlgkyKSVSICYVEGNDIMKPFFEQFG 130
Cdd:PRK09831   60 INAQPVGFITCIEHY---------IDMLFVDPEYTRRGVASALLkPLI----------KSESELTVDASITAKPFFERYG 120


                  ....*.
gi 1236168408 131 FSVVEQ 136
Cdd:PRK09831  121 FQTVKQ 126
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-106 1.11e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.72  E-value: 1.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1236168408  50 IYVDDEPVGFVQYYsnHENGRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLG 106
Cdd:cd04301     4 AEDDGEIVGFASLS--PDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERG 58
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
52-148 2.57e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.40  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  52 VDDEPVGFVQYYSNHENGRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLGkyksVSICYVEGNDIMKPFFEQFGF 131
Cdd:COG3153    46 DDGEIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERG----ARAVVLLGDPSLLPFYERFGF 121

                          90
                  ....*....|....*..
gi 1236168408 132 SVVEQDEFDETIMRLFF 148
Cdd:COG3153   122 RPAGELGLTLGPDEVFL 138
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 50-131 1.10e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.21  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  50 IYVDDEPVGFVQYYSNHEngRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLGkYKSVSICYVEGNDIMKPFFEQF 129
Cdd:pfam00583  38 AEEDGELVGFASLSIIDD--EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERG-CERIFLEVAADNLAAIALYEKL 114


                  ..
gi 1236168408 130 GF 131
Cdd:pfam00583 115 GF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
52-146 6.71e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 48.84  E-value: 6.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  52 VDDEPVGFVQYYSNHENGRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLGkYKSVSICYVEGNDIMKPFFEQFGF 131
Cdd:COG1247    59 EDGEVVGFASLGPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARG-YRRLVAVVLADNEASIALYEKLGF 137

                          90       100
                  ....*....|....*....|....
gi 1236168408 132 SVVEQDE---------FDETIMRL 146
Cdd:COG1247   138 EEVGTLPevgfkfgrwLDLVLMQK 161
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 22-141 1.25e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 44.98  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  22 TKEQEDFVALNSESIAASKFFDYYInrgIYVDDEPVGFVQYYSNHENgrpeEVFIDQLMIDIKHQRKGFGSKAIPLVLEE 101
Cdd:COG1246     8 PDDVPAILELIRPYALEEEIGEFWV---AEEDGEIVGCAALHPLDED----LAELRSLAVHPDYRGRGIGRRLLEALLAE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1236168408 102 IKNLGkYKSVsicYVEGNDIMKPFFEQFGFSVVEQDEFDE 141
Cdd:COG1246    81 ARELG-LKRL---FLLTTSAAIHFYEKLGFEEIDKEDLPY 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 20-136 1.73e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 44.66  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  20 EITKEQEDFVALnSESIAAS-----KFFDYYINRGIYVDDEPVGFVQYysNHENGrpEEVFIDQLMIDIKHQRKGFGSKA 94
Cdd:COG0454     5 KATPEDINFILL-IEALDAElkameGSLAGAEFIAVDDKGEPIGFAGL--RRLDD--KVLELKRLYVLPEYRGKGIGKAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1236168408  95 IPLVLEEIKNLGkYKSVSICYVEGNDIMKPFFEQFGFSVVEQ 136
Cdd:COG0454    80 LEALLEWARERG-CTALELDTLDGNPAAIRFYERLGFKEIER 120
PRK09831 PRK09831
GNAT family N-acetyltransferase;
52-136 2.19e-06

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 44.56  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  52 VDDEPVGFVQYYSNHengrpeevfIDQLMIDIKHQRKGFGSKAI-PLVleeiknlgkyKSVSICYVEGNDIMKPFFEQFG 130
Cdd:PRK09831   60 INAQPVGFITCIEHY---------IDMLFVDPEYTRRGVASALLkPLI----------KSESELTVDASITAKPFFERYG 120


                  ....*.
gi 1236168408 131 FSVVEQ 136
Cdd:PRK09831  121 FQTVKQ 126
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 58-138 7.52e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 41.95  E-value: 7.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  58 GFVQYYSNHEngrPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLGkYKSVSICYVEGNDIMKPFFEQFGFSVVEQD 137
Cdd:COG0456     1 GFALLGLVDG---GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERG-ARRLRLEVREDNEAAIALYEKLGFEEVGER 76


                  .
gi 1236168408 138 E 138
Cdd:COG0456    77 P 77
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-106 1.11e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.72  E-value: 1.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1236168408  50 IYVDDEPVGFVQYYsnHENGRPEEVFIDQLMIDIKHQRKGFGSKAIPLVLEEIKNLG 106
Cdd:cd04301     4 AEDDGEIVGFASLS--PDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERG 58
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 50-133 4.45e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 39.75  E-value: 4.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  50 IYVDDEPVGFVQYYSNHENGRPEEVFIdqlMIDIKHQRKGFGSKaiplVLEEIKNLGKYKSVSICYVEGNDIMKPFFEQF 129
Cdd:pfam13508   8 AEDDGKIVGFAALLPLDDEGALAELRL---AVHPEYRGQGIGRA----LLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80


                  ....
gi 1236168408 130 GFSV 133
Cdd:pfam13508  81 GFEE 84
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 53-146 8.84e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 37.67  E-value: 8.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236168408  53 DDEPVGFVQYYsnHENGRPEEVFIDqLMIDIKHQRKGFGSKAIPLVLEEIKNLGKYKSVSICYVEGNDIMKPFFEQFGFS 132
Cdd:COG1670    70 DGELIGVVGLY--DIDRANRSAEIG-YWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFR 146

                          90       100
                  ....*....|....*....|...
gi 1236168408 133 ---VVEQDEF------DETIMRL 146
Cdd:COG1670   147 legTLRDALVidgryrDHVLYSL 169
PRK07757 PRK07757
N-acetyltransferase;
79-143 9.87e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 34.40  E-value: 9.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1236168408  79 LMIDIKHQRKGFGSKAIPLVLEEIKNLGKYKSVSICYVEGndimkpFFEQFGFSVVEQDEFDETI 143
Cdd:PRK07757   71 LAVSEDYRGQGIGRMLVEACLEEARELGVKRVFALTYQPE------FFEKLGFREVDKEALPQKV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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