|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-867 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1449.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 1 MQDIYRHQDIESHVQRHWEQTQTFTVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWD 80
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 81 AFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCP 160
Cdd:COG0495 81 AFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 161 QDFTVLANEQVIDGRCWRCDSKVERKSIPQWFIKITAYADQLLDDLDELEHWPEQVKTMQRHWIGRSEGVEIRFPLDHDE 240
Cdd:COG0495 161 VDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 241 KTdLTVYSTRPDTLMGVAFIAIAPDHFFSAEIA--KNVPALATFIEECRHIKMAEAETATIEKKGIDTGFFALHPLTGKK 318
Cdd:COG0495 241 EK-ITVFTTRPDTLFGATFMVLAPEHPLVKELAtpEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 319 IPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAVILLEDGTEPDVQKKPLIEKGRLCHSGEFNGLSYQESCD 398
Cdd:COG0495 320 IPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDILEEAYTGDGVLINSGEFDGLDSEEAKE 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 399 RIIDKLVDSGTGQRKVNYRLRDWGVSRQRYWGAPIPMITLEDGRIIGTPEDQLPVILPE-KTFIKDMINPLKADQDWAKT 477
Cdd:COG0495 400 AIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEdVDFDPTGGSPLARAPEWVNV 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 478 S--VAGQLGIRETDTFDTFIESSWYYARYACPKYDQGMIEKAAANYWLPVDQYVGGIEHAIMHLLYFRFFHKLMRDQGLV 555
Cdd:COG0495 480 TcpKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLV 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 556 DSKEPAKRLLCQGMVLAdafyynaqngervwvsptevtVERDNkgqflnafdaqgrdLIHAGMSKMSKSKNNGIDPQAIV 635
Cdd:COG0495 560 SFDEPFKRLLTQGMVLE---------------------VGKDG--------------VVIGGIEKMSKSKGNVVDPDEII 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 636 EKYGADTVRLFMMFASAPEMTLEWQESGLEGAYRFLKRLWRFVFDHViqgPTQPLKKENLNSTQKNLRRNLHKTIAKVTD 715
Cdd:COG0495 605 EKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEA---EALKLDVADLSEADKELRRALHKTIKKVTE 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 716 DIGrRQTFNTAIAAIMELMNQLYRAPTNTEQDRALIQEACISVIKMLYPFTPHISFILWQHLHQSPDethplnIDDSLWP 795
Cdd:COG0495 682 DIE-RLRFNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGS------VADAPWP 754
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1236882790 796 VVDQNALIEDETLVVIQINGKMRAKITVPMNSTQQEVYESALQEPTVIKHLKGITPCHVIYVPNKLLNLVVN 867
Cdd:COG0495 755 EADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
5-867 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1226.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 5 YRHQDIESHVQRHWEQTQTFTVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGL 84
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 85 PAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFT 164
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 165 VLANEQVI-DGRCWRCDSKVERKSIPQWFIKITAYADQLLDDLDELEHWPEQVKTMQRHWIGRSEGVEIRFPL-DHDEKt 242
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIaDHDEK- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 243 dLTVYSTRPDTLMGVAFIAIAPDHFFSAEIAKNVPALATFIEECRHIKMAEAETATIEKKGIDTGFFALHPLTGKKIPIW 322
Cdd:TIGR00396 240 -ITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPIW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 323 VANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAVILLEDGTEPdvQKKPLIEKGRLCHSGEFNGLSYQESCDRIID 402
Cdd:TIGR00396 319 VANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLS--LTAAYTEDGVLVNSGEFNGLNSSEARNAIID 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 403 KLVDSGTGQRKVNYRLRDWGVSRQRYWGAPIPMITLEDGRIIGTPEDQLPVILPEKTFIK-DMINPLKADQDWAKTSV-- 479
Cdd:TIGR00396 397 MLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDgDGGSPLSRIPEWVNVTCps 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 480 AGQLGIRETDTFDTFIESSWYYARYACPKYDQGMIEKAAANYWLPVDQYVGGIEHAIMHLLYFRFFHKLMRDQGLVDSKE 559
Cdd:TIGR00396 477 CGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKE 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 560 PAKRLLCQGMVLAdafYYNAQNGErvwvSPTEVTVERDNKGqflnaFDAQGRDLIHAGMSKMSKSKNNGIDPQAIVEKYG 639
Cdd:TIGR00396 557 PFKKLINQGMVLG---FYYPPNGK----VPADVLTERDEKG-----KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYG 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 640 ADTVRLFMMFASAPEMTLEWQESGLEGAYRFLKRLWRFVFDHVIQGPTQPLKKENLNSTQKNLRRNLHKTIAKVTDDIGR 719
Cdd:TIGR00396 625 ADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEK 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 720 RQTFNTAIAAIMELMNQLYRAPtnteqDRALIQEACISVIKMLYPFTPHISFILWQHLHQSPDEthplnIDDSLWPVVDQ 799
Cdd:TIGR00396 705 RESFNTAISAMMELLNKLYKAK-----KEALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFI-----IDNAKWPVVDE 774
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1236882790 800 NALIEDETLVVIQINGKMRAKITVPMNSTQQEVYESALQEPTVIKHLKGITPCHVIYVPNKLLNLVVN 867
Cdd:TIGR00396 775 TALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
5-866 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 800.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 5 YRHQDIESHVQRHWEQTQTFTVKE--DPKKEKYYCLAMWPYPSGR-LHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDA 81
Cdd:PLN02563 80 YPFHEIEPKWQRYWEENRTFRTPDdvDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 82 FGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQ 161
Cdd:PLN02563 160 FGLPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPA 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 162 DFTVLANEQVIDGRCWRCDSKVERKSIPQWFIKITAYAdQLLDDLDELEHWPEQVKTMQRHWIGRSEGVEIRFPLD---- 237
Cdd:PLN02563 240 LGTVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYA-DRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVLdgeg 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 238 HDEKTDLTVYSTRPDTLMGVAFIAIAPDHFF-----SAEIAKNVPALATFIEecRHIKMAEAETATiEKKGIDTGFFALH 312
Cdd:PLN02563 319 KERDEKITVYTTRPDTLFGATYLVVAPEHPLlssltTAEQKEAVEEYVDAAS--RKSDLERTELQK-EKTGVFTGSYAIN 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 313 PLTGKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAVILLEDGTEPDVqKKPLIEKGRLCHSGE----F 388
Cdd:PLN02563 396 PATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDDA-EKAYTGEGVIVNSSSsgldI 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 389 NGLSYQESCDRIIDKLVDSGTGQRKVNYRLRDWGVSRQRYWGAPIPMITLED-GRIIGTPEDQLPVILPEKTFIK---DM 464
Cdd:PLN02563 475 NGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDsGEPVPVPESDLPLTLPELDDFTptgTG 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 465 INPLKADQDWAKTSVA--GQLGIRETDTFDTFIESSWYYARYACPKYDQGMIEKAAANYWLPVDQYVGGIEHAIMHLLYF 542
Cdd:PLN02563 555 EPPLAKAVSWVNTVDPssGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYA 634
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 543 RFFHKLMRDQGLVDSKEPAKRLLCQGMVLADAFYYNAQNGERVWVSPTEVTVERDNKGQFLNAFD-----------AQGR 611
Cdd:PLN02563 635 RFWHKVLYDIGVVSTKEPFQCLVNQGMILGEVEYTAFKDSDGEYVSADTADRLGELQQEKIPEEKviksgdsfvlkDDPS 714
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 612 DLIHAGMSKMSKSKNNGIDPQAIVEKYGADTVRLFMMFASAPEMTLEWQESGLEGAYRFLKRLWRfvfdhVIQGPTQPLK 691
Cdd:PLN02563 715 IRLIARAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWR-----LVVGAPLPDG 789
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 692 KENLNSTQKNLR------RNLHKTIAKVTDDI-GRRqtFNTAIAAIMELMNQLYRAptnTEQDRALIQEacisVIKMLYP 764
Cdd:PLN02563 790 SFRDGTVVTDEEpsleqlRLLHKCIAKVTEEIeSTR--FNTAISAMMEFTNAAYKW---DKVPREAIEP----FVLLLSP 860
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 765 FTPHISFILWQHL-HQSPDETHPlniddslWPVVDQNALIEDETLVVIQINGKMRAKITVPMNSTQQEVYESALQEPTVI 843
Cdd:PLN02563 861 YAPHLAEELWFRLgHSNSLAYEP-------WPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLS 933
|
890 900
....*....|....*....|...
gi 1236882790 844 KHLKGITPCHVIYVPNKLLNLVV 866
Cdd:PLN02563 934 KYLDGKEIKKRIYVPGKILNVIL 956
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-659 |
4.90e-116 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 355.79 E-value: 4.90e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 34 KYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQ 113
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 114 SLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCpqdftvlaneqvidgrcwrcdskverKSIPQWFI 193
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 194 KITAYAdqllddldelehWPEQVKTMQRHWIGRSEGVEirfpldhdektdltvystrpdtlmgvafiaiapdhffsaeia 273
Cdd:cd00812 135 KYSETE------------WKEKLLKDLEKLDGWPEEVR------------------------------------------ 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 274 knvpalatfieecrhikmaeaetatiekkgidtgffalhpltgkkipiwvanfvlmeygtgavmgvpgHDQRDWefatqy 353
Cdd:cd00812 161 --------------------------------------------------------------------AMQENW------ 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 354 hlpikavilledgtepdvqkkpliekgrlchsgefnglsyqescdriIdklvdsgtgqrkvnyrlrdwGVSRQRYWGAPI 433
Cdd:cd00812 167 -----------------------------------------------I--------------------GCSRQRYWGTPI 179
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 434 PMitledgriigtpedqlpvilpektfikdminplkadqdwaktsvagqlgireTDTFDTFIESSWYYARYACPKYDQGM 513
Cdd:cd00812 180 PW----------------------------------------------------TDTMESLSDSTWYYARYTDAHNLEQP 207
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 514 IE------KAAANYWLPVDQYVGGIEHAIMHLLYFRFFHKLMRDQGLVdSKEPAKRLLCQGMVLAdafyynaqNGErvwv 587
Cdd:cd00812 208 YEgdlefdREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLL--------EGE---- 274
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1236882790 588 sptevtverdnkgqflnafdaqgrdlihagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMFASAPEMTLEW 659
Cdd:cd00812 275 --------------------------------KMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
221-404 |
1.87e-98 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 304.85 E-value: 1.87e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 221 RHWIGRSEGVEIRFPLDHDEKTdLTVYSTRPDTLMGVAFIAIAPDHFFSAEIAKNVPALATFIEECRHIKMAEAETATIE 300
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEK-IEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNTSEIERTSETKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 301 KKGIDTGFFALHPLTGKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAVILLEDGTE-PDVQKKPLIEK 379
Cdd:pfam13603 80 KEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLdLDIMTEAYTEE 159
|
170 180
....*....|....*....|....*
gi 1236882790 380 GRLCHSGEFNGLSYQESCDRIIDKL 404
Cdd:pfam13603 160 GILVNSGEFDGLDSEEAKEAIIKKL 184
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-799 |
8.37e-91 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 306.22 E-value: 8.37e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 1 MQDIYRHQDIESHVQRHWEQTQTFTVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 81 AFGLPAEG-----AAIKNKTSP-----------IDWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLY 144
Cdd:TIGR00422 81 HAGIATQVkvekkLGAEGKTKHdlgreefrekiWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 145 EKGLVYKKTSDVNWCPQDFTVLANEQVIDgrcwrcdskverksipqwfikitayadqllddldelehwpEQVKTMQRHwi 224
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEVEY----------------------------------------KEVKGKLYY-- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 225 grsegveIRFPLDHDEKTDLTVYSTRPDTLMGVAFIAIAPDHffsaeiaknvpalatfiEECRHIkmaeaetatIEKKGI 304
Cdd:TIGR00422 199 -------IRYPLANGSKDYLVVATTRPETMFGDTAVAVHPED-----------------ERYKHL---------IGKKVI 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 305 dtgffalHPLTGKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAvILLEDGTepdvqkkpLIEkgrlcH 384
Cdd:TIGR00422 246 -------LPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFIN-ILDEDGL--------LNE-----N 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 385 SGEFNGLSYQESCDRIID------KLVDS-------GTGQR--------------------------------------- 412
Cdd:TIGR00422 305 AGKYQGLTRFEARKKIVEdlkeegLLVKIephthnvGTCWRsgtvvepllskqwfvkvekladkaleaaeegeikfvpkr 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 413 -KVNYR-----LRDWGVSRQRYWGAPIPMITL-EDGRIIGTPEDQLPVilpektfikdminplkadqDWAKTSVAGQLgI 485
Cdd:TIGR00422 385 mEKRYLnwlrnIKDWCISRQLIWGHRIPVWYCkECGEVYVAKEEPLPD-------------------DKTNTGPSVEL-E 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 486 RETDTFDTFIESS-WYYARYACPKYDQGMiekaaANYWlPVDQYVGGieHAImhlLYFRFFHKLMRDQGLVDSKePAKRL 564
Cdd:TIGR00422 445 QDTDVLDTWFSSSlWPFSTLGWPDETKDL-----KKFY-PTDLLVTG--YDI---IFFWVARMIFRSLALTGQV-PFKEV 512
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 565 LCQGMVladafyynaqngervwvsptevtverdnkgqflnaFDAQGRdlihagmsKMSKSKNNGIDPQAIVEKYGADTVR 644
Cdd:TIGR00422 513 YIHGLV-----------------------------------RDEQGR--------KMSKSLGNVIDPLDVIEKYGADALR 549
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 645 LFMMFASAPEMTLEWQESGLEGAYRFLKRLW---RFVFDHVIQGPTQPLKKENLNSTQKNLRRNLHKTIAKVTDDIGRRQ 721
Cdd:TIGR00422 550 FTLASLVTPGDDINFDWKRVESARNFLNKLWnasRFVLMNLSDDLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYR 629
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 722 tFNTAIAAIMELM-------------NQLYRAptNTEQDRALIQEACI---SVIKMLYPFTPHISFILWQHLHQSPDeth 785
Cdd:TIGR00422 630 -FAEAAKALYEFIwndfcdwyielvkYRLYNG--NEAEKKAARDTLYYvldKALRLLHPFMPFITEEIWQHFKEGAD--- 703
|
890
....*....|....
gi 1236882790 786 plNIDDSLWPVVDQ 799
Cdd:TIGR00422 704 --SIMLQSYPVVDA 715
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
5-826 |
4.02e-71 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 250.49 E-value: 4.02e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 5 YRHQDIESHVQRHWEQTQTFTVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGL 84
Cdd:PRK13208 10 YDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 85 PAE-------GaaI-KNKTSP-------IDWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLV 149
Cdd:PRK13208 90 PTErkvekyyG--IrKDDISReefielcRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 150 YKKTSDVNWCPQDFTVLAneqvidgrcwrcDSKVERKSIPqwfikiTAYadqllddldelehwpeqvktmqrhwigrseg 229
Cdd:PRK13208 168 YRAEAPVLWCPRCETAIA------------QAEVEYRERE------GKL------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 230 VEIRFPLDHDEktDLTVYSTRPDtLMG--VAfIAIAPDHffsaeiaknvpalatfiEECRHIKMAEAETatiekkgidtg 307
Cdd:PRK13208 199 NYIKFPVEDGE--EIEIATTRPE-LLPacVA-VVVHPDD-----------------ERYKHLVGKTAIV----------- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 308 ffalhPLTGKKIPIWVANFVLMEYGTGAVM----GvpghDQRDWEFATQYHLPIKAVIlleDgtepdvqkkpliEKGRL- 382
Cdd:PRK13208 247 -----PLFGVEVPILADPLVDPDFGTGAVMictfG----DKTDVTWWRELNLPTRIII---D------------EDGRMt 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 383 CHSGEFNGLSYQESCDRIIDKLVDSG--TGQRKV---------------------------------------------N 415
Cdd:PRK13208 303 EAAGKLAGLTIEEARKKIVEDLKSGGllGKQEPIkhnvkfcercdtpleilvtrqwfikvldlkeellergkeinwypeH 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 416 YRLR----------DWGVSRQRYWGAPIPM-ITLEDGRIIGTPEDQLPVilpektfikdmiNPLKADQDWAKTSVAGQLG 484
Cdd:PRK13208 383 MRVRlenwieglnwDWCISRQRYFGTPIPVwYCKDCGHPILPDEEDLPV------------DPTKDEPPGYKCPQCGSPG 450
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 485 IR-ETDTFDTFIESSwyyaryacpkydqgmiekaaanywLPVdQYVGGIEHAimHLLYFRFFHKLMRDQG---------- 553
Cdd:PRK13208 451 FEgETDVMDTWATSS------------------------ITP-LIVTGWERD--EDLFEKVFPMDLRPQGhdiirtwlfy 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 554 ------LVDSKEPAKRLLCQGMVLADafyynaqNGErvwvsptevtverdnkgqflnafdaqgrdlihagmsKMSKSKNN 627
Cdd:PRK13208 504 tilrayLLTGKLPWKNIMISGMVLDP-------DGK------------------------------------KMSKSKGN 540
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 628 GIDPQAIVEKYGADTVRLFmmFASAP---EMTLEWQEsgLEGAYRFLKRLW---RFVfDHvIQGPTQPLKKENLNSTQKN 701
Cdd:PRK13208 541 VVTPEELLEKYGADAVRYW--AASARlgsDTPFDEKQ--VKIGRRLLTKLWnasRFV-LH-FSADPEPDKAEVLEPLDRW 614
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 702 LRRNLHKTIAKVTDDIGRRQtFNTAIAAIM------------ELM-NQLYRAPTNTEQDRAL--IQEACISVIKMLYPFT 766
Cdd:PRK13208 615 ILAKLAKVVEKATEALENYD-FAKALEEIEsffwhvfcddylELVkSRAYGEDEEEEQKSARytLYTVLDTLLRLLAPFL 693
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1236882790 767 PHISFILWQHLHQSpdethplNIDDSLWPVVDQNALIE-DETL--VVIQINGKMR-AKIT--VPMN 826
Cdd:PRK13208 694 PFITEEVWSWLYGG-------SVHRASWPEPDEELIDEeDEELgeLAKEILSAVRkYKSEagLSLN 752
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
14-651 |
2.38e-65 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 229.99 E-value: 2.38e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 14 VQRHWEQTQTF-TVKEDPKKEKYYCLAMWP-YPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGA-- 89
Cdd:pfam00133 2 IYEFWDEQGYFkPELEKRKGKPSFTIHDGPpNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVve 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 90 ---AIKNKTSPIDWTKANI------------QYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTS 154
Cdd:pfam00133 82 kklGIKEKKTRHKYGREEFrekcrewkmeyaDEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 155 DVNWCPQDFTVLANeqvidgrcwrcdSKVERKSI--PQWFIkitayadqllddldelehwpeqvktmqrhwigrsegvei 232
Cdd:pfam00133 162 LVNWSPALNTALSN------------LEVEYKDVkgPSIHV--------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 233 RFPLDHDEKTDLTVYSTRPDTLMGVAFIAIAPDHFFSAEIAKNVPAlatfieECRHIKMAEAETA-TIEK--KGID-TGF 308
Cdd:pfam00133 191 AFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVITGEGYILA------EALLKSLYKKGTDkKILEdfRGKElEGK 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 309 FALHPLTGKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIkAVILLEDGT----EPDVQK----------- 373
Cdd:pfam00133 265 EAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEV-INPVDDDGTfteeAPDFQGvyrfdarkkiv 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 374 KPLIEKGRLCHSgEFNGLSYqESCDR----IIDKLV------------DSGTGQRKVNY--------------RLRDWGV 423
Cdd:pfam00133 344 ELLTEKGLLLKI-EPFTHSY-PFCWRsgtpIIPRATpqwfvrmdeladQALEAVEKVQFvpksgekryfnwlaNIQDWCI 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 424 SRQRYWGAPIPMITLEDGriigtpeDQLPVILPEKTFIKDMINPLKADQDWAKTSV------AGQLgIRETDTFDTFIES 497
Cdd:pfam00133 422 SRQRWWGHPIPAWVSKDT-------EEVVCRGELFELVAGRFEEEGSIKWLHREAKdklgygKGTL-EQDEDVLDTWFSS 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 498 -SWYYARYACPKYDQGMIEKAaanywLPVDQYVGGIEhaimhLLYFRFFHKLMRDQGLVDSkEPAKRLLCQGMVLadafy 576
Cdd:pfam00133 494 gSWPFSTLGWPFVNTEEFKKF-----FPADMLLEGSD-----QTRGWFYRMIMLSTALTGS-VPFKNVLVHGLVR----- 557
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1236882790 577 ynaqngervwvsptevtverdnkgqflnafDAQGRdlihagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMFAS 651
Cdd:pfam00133 558 ------------------------------DEQGR--------KMSKSLGNVIDPLDVIDKYGADALRLWLANSD 594
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
9-809 |
4.55e-50 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 190.28 E-value: 4.55e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 9 DIESHVQRHWEQTQTF-TVKEDPK-KEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPA 86
Cdd:TIGR00392 10 KREEKILAFWQENDIFeKVKKLNKgKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHGLPI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 87 E-------GAAIKNKTSPI----------DWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLV 149
Cdd:TIGR00392 90 EhkvekklGISGKKEISSLeieefrekcrEFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHEKGLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 150 YKKTSDVNWCPQDFTVLANEQVidgrcwrcdskverksipqwfikitayadqllddldelehwpEQVKTMQRHwigRSEG 229
Cdd:TIGR00392 170 YRGLKPVYWSPRCRTALAEAEV------------------------------------------EYKENYKDV---KDPS 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 230 VEIRFPLDHDEKTD-------LTVYSTRPDTLMGVAFIAIAPDhFFSAEIAKNVPALATFIEECRHIKMAE--AETATIE 300
Cdd:TIGR00392 205 IYVKFPVKKDKKTYlkvklssLLIWTTTPWTLPSNLAIAVHPD-FEYALVQDNTKVEYFILAKKLVEKLYNkaGSDYEII 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 301 K--KGID-TGFFALHPLTGKKIPIWV-------ANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPI------KAVILLE 364
Cdd:TIGR00392 284 KtfKGSDlEGLEYEHPLYDFVSQLKEgapvvigGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlspvdeKGVYTEG 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 365 DGTEPDVQKK---------------PLIEKGRLCHSGEfnglsYQES---CDR-------------------IIDKLVDS 407
Cdd:TIGR00392 364 VNDFQGRFVKdadkdiikankiiieQLKDKGLLLKAEK-----ITHSyphCWRtktpviyrateqwfiktkdIKDQMLEQ 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 408 gtgQRKVNY-------RL-------RDWGVSRQRYWGAPIPMITLEDG---RIIGTPEdQLPVILPEK---TFIKDMINP 467
Cdd:TIGR00392 439 ---IKKVNWvpewgegRFgnwlenrPDWCISRQRYWGIPIPIWYCEDTgepIVVGSIE-ELIELIELKgidAWFEDLHRD 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 468 LKadqDWAKT-SVAGQLGIRETDTFDTFIES-SWYYARYACPKYDQGMIEKAAANYWLP-VDQYVGgiehaimhllyfrF 544
Cdd:TIGR00392 515 FL---DKITLkSGDGGEYRRVPDVLDVWFDSgSMPYASIHYPFENEKFKEVFPADFILEgSDQTRG-------------W 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 545 FHKLMRDQGLVDSKEPAKRLLCQGMVLadafyynaqngervwvsptevtverdnkgqflnafDAQGRdlihagmsKMSKS 624
Cdd:TIGR00392 579 FYSSLAIGTALFGQAPYKNVITHGFTL-----------------------------------DEKGR--------KMSKS 615
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 625 KNNGIDPQAIVEKYGADTVRLFMMFaSAPEMTLEWQESGLEGAYRFLKRLW----RF-----VFDHvIQGPTQPLKKENL 695
Cdd:TIGR00392 616 LGNVVDPLKVINKYGADILRLYVAS-SDPWEDLRFSDEILKQVVEKYRKIRwntyRFlltyaNLDK-FDPLFNSVAVEKF 693
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 696 NSTQKNLRRNLHKTIAKVTDDIGRRQtFNTAIAAIM-----ELMN---QLYRAPTNTEQD-------RALIQEACISVIK 760
Cdd:TIGR00392 694 PEEDRWILSRLNSLVEEVNEALEKYN-FHKVLRALQdfiveELSNwyiRIIRDRLYCEAKdndkraaQTTLYYALLTLVR 772
|
890 900 910 920
....*....|....*....|....*....|....*....|....*....
gi 1236882790 761 MLYPFTPHISFILWQHLHQSPDETHplnIDDSLWPVVDQNALieDETLV 809
Cdd:TIGR00392 773 LLAPFLPHTAEEIYQNLPGGEEEES---VHLNLWPEVDEEFI--DEALE 816
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-837 |
5.98e-48 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 184.30 E-value: 5.98e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 48 LHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAA--IKNKTS------------PIDW-----TKANI-QY 107
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAerIARGDPetielykslygiPEEElekfkDPEYIvEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 108 ----MKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLANEQVIDGrcwrcdskv 183
Cdd:PRK12300 81 fseeAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG--------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 184 ERKSIPQWFIkitayadqllddldelehwpeqvktmqrhwigrsegveIRFPldHDEKTDLTVYSTRPDTLMGVAFIAIA 263
Cdd:PRK12300 152 EEPEIVEYTL--------------------------------------IKFE--ESEDLILPAATLRPETIFGVTNLWVN 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 264 PD-HFFSAEIAKNVPALAtfiEEC--------RHIKMAEaetatiEKKGID-TGFFALHPLTGKKIPIWVANFVLMEYGT 333
Cdd:PRK12300 192 PDaTYVKAEVDGEKWIVS---KEAaeklsfqdRDVEIIE------EIKGSElIGKKVKNPVTGKEVPILPADFVDPDNGT 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 334 GAVMGVPGHDQRDW--------EFATQYHLPIKAVILLED-GTEP--DV--------QKKPLIE------------KGRL 382
Cdd:PRK12300 263 GVVMSVPAHAPYDYvalrdlkkNKELLDVIEPIPLIEVEGyGEFPakEVveklgiksQEDPELEeatkevyraefhKGVL 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 383 C-HSGEFNGLSYQESCDRIIDKLVDSGTG-------QRKVnyrlrdwgVSRqryWGAPIPMITLEDGRII--GTPE---- 448
Cdd:PRK12300 343 KeNTGEYAGKPVREAREKITKDLIEKGIAdimyefsNRPV--------YCR---CGTECVVKVVKDQWFIdySDPEwkel 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 449 -----DQLpVILPE--KTFIKDMINPLKadqDWAKTSVAGqLGIREtdTFDT--FIE----SSWYYARYACPKY------ 509
Cdd:PRK12300 412 ahkalDNM-EIIPEeyRKEFENTIDWLK---DRACARRRG-LGTRL--PWDEewIIEslsdSTIYMAYYTIAHKireygi 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 510 ---------------DQGMIEKAAA----------------NYWLPVDQYVGGIEHAIMHLLYFRFFHKLMRDQglvdSK 558
Cdd:PRK12300 485 kpeqltpeffdyvflGKGDPEEVSKktgipkeileemreefLYWYPVDWRHSGKDLIPNHLTFFIFNHVAIFPE----EK 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 559 EPakrllcQGMVLadafyynaqNGervWvspteVTVErdnkGQflnafdaqgrdlihagmsKMSKSKNNGIDPQAIVEKY 638
Cdd:PRK12300 561 WP------RGIVV---------NG---F-----VLLE----GK------------------KMSKSKGNVIPLRKAIEEY 595
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 639 GADTVRLFMMFASAPEMTLEWQESGLEGAYRFLKRLWRFVFDHVIQGptqplKKENLNSTQKNLRRNLHKTIAKVTDDIG 718
Cdd:PRK12300 596 GADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKELIEIG-----GEEELRFIDKWLLSRLNRIIKETTEAME 670
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 719 RRQTFNTAIAAIMELMNQL--YRAPTNTEQdRALIQEACISVIKMLYPFTPHISFILWQHL-HQSPDETHPlniddslWP 795
Cdd:PRK12300 671 SFQTRDAVQEAFYELLNDLrwYLRRVGEAN-NKVLREVLEIWIRLLAPFTPHLAEELWHKLgGEGFVSLEK-------WP 742
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*...
gi 1236882790 796 VVDQ--------------NALIED--ETLVVIQINGKmRAKITVPmNSTQQEVYESAL 837
Cdd:PRK12300 743 EPDEskideeaelaeeyvKRLIEDirEILKVAKIKPK-KVYIYVA-PDWKYEVLEIAA 798
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
659-777 |
2.53e-47 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 163.93 E-value: 2.53e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 659 WQESGLEGAYRFLKRLWRFVFDHVIQGPTqPLKKENLNSTQKNLRRNLHKTIAKVTDDIGRRQtFNTAIAAIMELMNQLY 738
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAA-PAAAAELSEEDKELRRKLHKTIKKVTEDIERLR-FNTAIAALMELVNALY 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 1236882790 739 RAPTNTEQDRALIQEACISVIKMLYPFTPHISFILWQHL 777
Cdd:cd07958 79 KYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-807 |
4.07e-46 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 178.37 E-value: 4.07e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 1 MQDIYRHQDIESHVQRHWEQTQTFtvKEDPKKEKYYCLAMwPYP--SGRLHMGHVRNYTITDVIARYQRMLGKNVL-QPm 77
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYF--KPDDNSKKPFSIVI-PPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwLP- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 78 GWDAFG----------LPAEGaaiKNKTspiD------------WTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRW 135
Cdd:PRK05729 81 GTDHAGiatqmvverqLAAEG---KSRH---DlgrekflekvweWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 136 EQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLANEQVidgrcwrcdskvERKSIPQWFikitayadqllddldelehwpeq 215
Cdd:PRK05729 155 VREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV------------EYKEVKGKL----------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 216 vktmqrhwigrsegVEIRFPLDhDEKTDLTVYSTRPDTLMG-VAfIAIAPD-----HFfsaeIAKNVpalatfieecrhi 289
Cdd:PRK05729 200 --------------WHIRYPLA-DGSDYLVVATTRPETMLGdTA-VAVNPEderykHL----IGKTV------------- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 290 kmaeaetatiekkgidtgffaLHPLTGKKIPIwVA-NFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKaVILLEDGTe 368
Cdd:PRK05729 247 ---------------------ILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMI-NIMDEDGT- 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 369 pdvqkkpLIEKGrlchsGEFNGLSYQESCDRIIDKLVDSG-------------TGQR---------------KV------ 414
Cdd:PRK05729 303 -------INENP-----GEYQGLDRFEARKAIVADLEELGllvkiephthsvgHSDRsgvviepylsdqwfvKMkplakp 370
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 415 -------------------NYR-----LRDWGVSRQRYWGAPIPMITLEDGRIIGTPEDqlpvilPEKtfikdminplKA 470
Cdd:PRK05729 371 aleavengeikfvperwekTYFhwmenIQDWCISRQLWWGHRIPAWYDEDGEVYVGREE------PEA----------RE 434
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 471 DQDWaktsvagqlgIRETDTFDT-FieSSW------------------YY----------------ARyacpkydqgMIe 515
Cdd:PRK05729 435 KALL----------TQDEDVLDTwF--SSAlwpfstlgwpektedlkrFYptsvlvtgfdiiffwvAR---------MI- 492
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 516 kaaanywlpvdqyvggiehaiMHLLYFR--------FFHklmrdqGLVdskepakrllcqgmvladafyynaqngervwv 587
Cdd:PRK05729 493 ---------------------MMGLHFTgqvpfkdvYIH------GLV-------------------------------- 513
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 588 sptevtveRDNKGQflnafdaqgrdlihagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMFASAPEMTLEWQESGLEGA 667
Cdd:PRK05729 514 --------RDEQGR------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGY 567
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 668 YRFLKRLW---RFVFDHV-IQGPTQPLKKENLNSTQKNLRRNLHKTIAKVTDDIgrrQTFNTAIAAimelmNQLYR---- 739
Cdd:PRK05729 568 RNFANKLWnasRFVLMNLeGADVGELPDPEELSLADRWILSRLNRTVAEVTEAL---DKYRFDEAA-----RALYEfiwn 639
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 740 -----------APTNTEQDRALIQEAcISV----IKMLYPFTPHISFILWQHLhqspdetHPLNIDDSL----WPVVDQN 800
Cdd:PRK05729 640 efcdwylelakPVLQEAAKRATRATL-AYVleqiLRLLHPFMPFITEELWQKL-------APLGIEESImlapWPEADEA 711
|
....*..
gi 1236882790 801 ALIEDET 807
Cdd:PRK05729 712 IDEAAEA 718
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
42-653 |
1.42e-44 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 165.50 E-value: 1.42e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 42 PYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEG-----AAIKNKTSP-----------IDWTKANI 105
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekkLGIEGKTRHdlgreeflekcWEWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 106 QYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLANEQVidgrCWRCDSKVER 185
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 186 KSIPQWFIKitayadqllddldelehwpeqVKTMQRHWIGRSEGVEIRFpldhdektdltvystrpdtlmgvafiaiAPD 265
Cdd:cd00817 166 LLKPQWFVK---------------------VKDLAKKALEAVKEGDIKF----------------------------VPE 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 266 HFFsaeiaknvpalatfieecrhikmaeaetatiekkgidtgffalhpltgkkipiwvanfvlMEYgtgavmgvpghdqR 345
Cdd:cd00817 197 RME------------------------------------------------------------KRY-------------E 203
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 346 DWefatqyhlpikavilLEDgtepdvqkkpliekgrlchsgefnglsyqescdriidklvdsgtgqrkvnyrLRDWGVSR 425
Cdd:cd00817 204 NW---------------LEN----------------------------------------------------IRDWCISR 216
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 426 QRYWGAPIPMITLED-GRIIGTPEDQLPVILPEKTFikdmiNPLKADQDWaktsvagqlgIRETDTFDTFIeSSWYYARY 504
Cdd:cd00817 217 QLWWGHRIPAWYCKDgGHWVVAREEDEAIDKAAPEA-----CVPCGGEEL----------KQDEDVLDTWF-SSSLWPFS 280
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 505 ACPKYDQgmIEKAAANYwlPVDQYVGGieHAImhlLYFRFFHKLMRDQGLVDsKEPAKRLLCQGMVladafyynaqnger 584
Cdd:cd00817 281 TLGWPEE--TKDLKKFY--PTSLLVTG--HDI---IFFWVARMIMRGLKLTG-KLPFKEVYLHGLV-------------- 336
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1236882790 585 vwvsptevtverdnkgqflnaFDAQGRdlihagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMFASAP 653
Cdd:cd00817 337 ---------------------RDEDGR--------KMSKSLGNVIDPLDVIDGYGADALRFTLASAATQ 376
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-798 |
2.19e-44 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 172.93 E-value: 2.19e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 1 MQDIYRHQDIESHVQRHWEQTQTFTVKEDPKKEKYyCLAMwPYP--SGRLHMGHVRNYTITDVIARYQRMLGKNVL-QPm 77
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TIVI-PPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwQP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 78 GWDAFG----------LPAEGaaiKNKTSpI----------DWTKANIQYMKKQLQSLGFAYDWSREltsckpeyyRweq 137
Cdd:COG0525 80 GTDHAGiatqavverqLAEEG---KSRHD-LgrekflervwEWKEESGGTITNQLRRLGASCDWSRE---------R--- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 138 wfFT--------------QLYEKGLVYKKTSDVNWCPQDFTVLANEQVI----DGRCWrcdskverksipqwfikitaya 199
Cdd:COG0525 144 --FTmdeglskavrevfvRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEheevKGHLW---------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 200 dqllddldeleHwpeqvktmqrhwigrsegveIRFPLDhDEKTDLTVYSTRPDTLMG-VAfIAIAPD-----HFfsaeIA 273
Cdd:COG0525 200 -----------H--------------------IRYPLA-DGSGYIVVATTRPETMLGdTA-VAVHPEderykHL----IG 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 274 KNVpalatfieecrhikmaeaetatiekkgidtgffaLHPLTGKKIPIwVA-NFVLMEYGTGAVMGVPGHDQRDWEFATQ 352
Cdd:COG0525 243 KTV----------------------------------ILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKR 287
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 353 YHLPIKaVILLEDGTepdvqkkpLIEKGrlchsGEFNGLSYQESCDRIIDKL--------VDS-----GTGQR------- 412
Cdd:COG0525 288 HNLPMI-NILDEDGT--------INENA-----GKYRGLDRFEARKAIVADLeelgllvkVEPhkhsvGHSDRsgtviep 353
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 413 ------------------------KVN---------YR-----LRDWGVSRQRYWGAPIPMITLEDGRII--GTPEDQLp 452
Cdd:COG0525 354 ylsdqwfvkmkplakpaieavedgEIKfvperwektYFhwmenIRDWCISRQLWWGHRIPAWYCPDGEVYvaRTEPEAC- 432
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 453 vilpektfikdminPLKADQDWaktsvagqlgIRETDTFDT-FieSSW------------------YY------------ 501
Cdd:COG0525 433 --------------AKAGSVNL----------TQDEDVLDTwF--SSAlwpfstlgwpektedlkyFYptsvlvtgfdii 486
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 502 ----ARyacpkydqgMiekaaanywlpvdqyvggiehaIMHLLYFR--------FFHklmrdqGLVdskepakrllcqgm 569
Cdd:COG0525 487 ffwvAR---------M----------------------IMMGLHFTgevpfkdvYIH------GLV-------------- 515
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 570 vladafyynaqngervwvsptevtveRDNKGQflnafdaqgrdlihagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMF 649
Cdd:COG0525 516 --------------------------RDEQGR------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAA 551
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 650 ASAPEMTLEWQESGLEGAYRFLKRLW---RFVFDHvIQGPTQPLKKENLNSTQKN---LRRnLHKTIAKVTDDIGRRQtF 723
Cdd:COG0525 552 LASPGRDIKFDEERVEGYRNFANKLWnasRFVLMN-LEGFDPGLDPDPEELSLADrwiLSR-LNKTIAEVTEALEKYR-F 628
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 724 NTAIAAI------------MELMNQLYRAPTNTEQDRAliQEACISV----IKMLYPFTPHISFILWQHLHQSPDEthpl 787
Cdd:COG0525 629 DEAAQALydfvwnefcdwyLELAKPRLYGGDEAAKRET--RATLVYVleqiLRLLHPFMPFITEEIWQKLPPRKEG---- 702
|
970
....*....|....*
gi 1236882790 788 nidDSL----WPVVD 798
Cdd:COG0525 703 ---ESImlapWPEAD 714
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
9-809 |
3.02e-42 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 166.79 E-value: 3.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 9 DIESHVQRHWEQTQTF--TVKEDPKKEKYYclamwPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVL-QPmGWDAFGLP 85
Cdd:COG0060 20 KREPEILKFWEENDIYekSREARAGRPKFVlhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPyVP-GWDCHGLP 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 86 AEGAAIKN---------KTSPIDWTKA-------NIQYMKKQLQSLGFAYDWSRE-LTsCKPEYYRWEQWFFTQLYEKGL 148
Cdd:COG0060 99 IELKVEKElgikkkdieKVGIAEFREKcreyalkYVDEQREDFKRLGVWGDWDNPyLT-MDPEYEESIWWALKKLYEKGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 149 VYKKTSDVNWCPQDFTVLAN-EqvidgrcwrcdskVE---RKSipqwfikITAYAdqllddldelehwpeqvktmqrhwi 224
Cdd:COG0060 178 LYKGLKPVPWCPRCGTALAEaE-------------VEykdVTS-------PSIYV------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 225 grsegveiRFPL------DHDEKTDLTVYSTRPDTLMGVAFIAIAPD------HFFSAE---IAKNvpALATFIEEcrhi 289
Cdd:COG0060 213 --------KFPVkdekalLLLEDAYLVIWTTTPWTLPANLAVAVHPDidyvlvEVTGGErliLAEA--LVEAVLKE---- 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 290 kmAEAETATIEK--KGID-TGFFALHPL-----TGKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAVI 361
Cdd:COG0060 279 --LGIEDYEVLAtfKGAElEGLRYEHPFyyvvgYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPV 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 362 lLEDGT-EPDVqkkpliekgrlchsGEFNGLSYQESCDRIIDKLVDSG--------------------------TGQ--- 411
Cdd:COG0060 357 -DDDGRfTEEA--------------PLFAGLFVKDANPAIIEDLKERGallarekithsyphcwrcktpliyraTPQwfi 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 412 -------------RKVNY-------RL-------RDWGVSRQRYWGAPIPMITLED-GRIIGTPE--------------D 449
Cdd:COG0060 422 smdklrdraleaiEKVNWipewgegRFgnmlenrPDWCISRQRYWGVPIPIWVCEDcGELHRTEEvigsvaelleeegaD 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 450 QLPVILPEKTFIkdminplkaDQDWAKTSVAGQLgIRETDTFDTFIES--SWYyaryacpkydqGMIEKAAANYWlPVDQ 527
Cdd:COG0060 502 AWFELDLHRPFL---------DETLKCPKCGGTM-RRVPDVLDVWFDSgsMHF-----------AVLENREELHF-PADF 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 528 YVGGI-EHaimhllyfR-FFHKLMRDQGLVDSKEPAKRLLCQGMVLadafyynaqngervwvsptevtverdnkgqflna 605
Cdd:COG0060 560 YLEGSdQT--------RgWFYSSLLTSTALFGRAPYKNVLTHGFVL---------------------------------- 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 606 fDAQGRdlihagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMfASAP--EMTLEWQesGLEGAYRFLKRLW---RFV-- 678
Cdd:COG0060 598 -DEDGR--------KMSKSLGNVVDPQEVIDKYGADILRLWVA-SSDYwgDLRFSDE--ILKEVRDVYRRLRntyRFLla 665
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 679 ----FDhviqgPTQP-LKKENLNStqknLRR----NLHKTIAKVTDDIGRRQtFNTAIAAIMELMNQ------------- 736
Cdd:COG0060 666 nlddFD-----PAEDaVPYEDLPE----LDRwilsRLNELIKEVTEAYDNYD-FHRAYRALHNFCVEdlsnwyldiskdr 735
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1236882790 737 LYRAPTNTEQDRA---LIQEACISVIKMLYPFTPHISFILWQHLHQSPDET-HpLniddSLWPVVDQNALieDETLV 809
Cdd:COG0060 736 LYTEAADSLDRRAaqtTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAEESvH-L----ADWPEVDEELI--DEELE 805
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-224 |
2.41e-33 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 131.00 E-value: 2.41e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 34 KYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAA-----IKNKTSPIDWT------- 101
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggRKKKTIWIEEFredpkef 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 102 -KANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKktsdvnwcpqdftvlaneqvidgrcwrcD 180
Cdd:cd00668 81 vEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYR----------------------------G 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1236882790 181 SKVERKSiPQWFIKITAYADQLLDDLDELEHWPEQVKTMQRHWI 224
Cdd:cd00668 133 THPVRIT-EQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWL 175
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
5-780 |
5.33e-32 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 134.35 E-value: 5.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 5 YRHQDIESHVQRHWEQTQTFTVKEDPKKEKYYCLAMwPYP--SGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAF 82
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHDRTRPPFSIVL-PPPnvTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 83 GLPAEGAAIKN-----KTSPID------------WTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYE 145
Cdd:PRK14900 98 GIATQMIVEKElkkteKKSRHDlgreaflervwaWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 146 KGLVYKKTSDVNWCPQDFTVLAneqvidgrcwrcDSKVERKSIPQWFIkitayadqllddldelehwpeqvktmqrhWig 225
Cdd:PRK14900 178 EGLIYREKKLINWCPDCRTALS------------DLEVEHEEAHQGEL-----------------------------W-- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 226 rsegvEIRFPLdHDEKTDLTVYSTRPDTLMGVAFIAIAP-DHFFSAEIAKNVpalatfieecrhikmaeaetatiekkgi 304
Cdd:PRK14900 215 -----SFAYPL-ADGSGEIVVATTRPETMLGDTAVAVHPlDPRYMALHGKKV---------------------------- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 305 dtgffaLHPLTGKKIPIwVANFVLME--YGTGAVMGVPGHDQRDWEFATQYHLPIKAVILlEDGT--------------E 368
Cdd:PRK14900 261 ------RHPITGRTFPI-VADAILVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIG-PDGRmtaeagplagldrfE 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 369 PDVQKKPLIEKGRLCHSGEFNGLSYQeSCDR---IIDKLVD---------------SGTGQRKVNY-------------- 416
Cdd:PRK14900 333 ARKEVKRLLAEQGLDRGAKPHVLPLG-RCQRsatILEPLLSdqwyvrieplarpaiEAVEQGRTRFipeqwtntymawmr 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 417 RLRDWGVSRQRYWGAPIPMITLEDGRIIGTPEDqlpvilPEktfikdminplkadqdwAKTSVAGQLGIRETDTFDTFIE 496
Cdd:PRK14900 412 NIHDWCISRQLWWGHQIPAWYCPDGHVTVARET------PE-----------------ACSTCGKAELRQDEDVLDTWFS 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 497 SS-WYYARYACPKydqgmiEKAAANYWLPVDQYVGGieHAIMHLLYFRFFHKLMRDQGLVdskePAKRLLCQGMVladaf 575
Cdd:PRK14900 469 SGlWPFSTMGWPE------QTDTLRTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEV----PFRTVYLHPMV----- 531
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 576 yynaqngervwvsptevtveRDNKGQflnafdaqgrdlihagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMFASAPEM 655
Cdd:PRK14900 532 --------------------RDEKGQ------------------KMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGR 573
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 656 TLEWQESGLEGAYRFLKRLW---RFVF----DHVIQGptQPLKKENLNSTQKNLRRNLHKTiakVTDDIGRRQTFNTAIA 728
Cdd:PRK14900 574 DIKLAKERIEGYRAFANKLWnasRFALmnlsGYQERG--EDPARLARTPADRWILARLQRA---VNETVEALEAFRFNDA 648
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1236882790 729 A--------------IMELMNQ-LYRA-PTNTEQDRALIQEACISVIKMLYPFTPHISFILWQHLHQS 780
Cdd:PRK14900 649 AnavyafvwhelcdwYIELAKEaLASEdPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQ 716
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-434 |
5.44e-28 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 121.65 E-value: 5.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 1 MQDIYRHQDIESHVQRHWEQTQTFTVKEDPK----KEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQP 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAKslnsGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 77 MGWDAFGLPAEGAAIK------NKT-----------SPIDWTK---ANIqymKKQLQSLGFAYDWSRELTSCKPEYYRWE 136
Cdd:PTZ00419 104 PGTDHAGIATQVVVEKklmkeeNKTrhdlgreeflkKVWEWKDkhgNNI---CNQLRRLGSSLDWSREVFTMDEQRSKAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 137 QWFFTQLYEKGLVYKKTSDVNWCPQDFTVLAneqvidgrcwrcDSKVERKSIPQ-WFIKITAYAdqllddldelehwpeq 215
Cdd:PTZ00419 181 KEAFVRLYEDGLIYRDTRLVNWCCYLKTAIS------------DIEVEFEEIEKpTKITIPGYD---------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 216 vKTMQRHWIgrsegVEIRFPLDHDEKTDLTVYSTRPDTLMGVAFIAIAPDhffsaeiaknvpalatfieECRHIKMaeae 295
Cdd:PTZ00419 233 -KKVEVGVL-----WHFAYPLEDSGQEEIVVATTRIETMLGDVAVAVHPK-------------------DERYKKL---- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 296 tatiekkgidTGFFALHPLT-GKKIPIwVAN--FVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIkAVILLEDGTepdvq 372
Cdd:PTZ00419 284 ----------HGKELIHPFIpDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPF-INIFTLDGK----- 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 373 kkpLIEKGrlchsGEFNGLsYQESCDRIIDK-------LVD-----------SGTG---------QRKVN---------- 415
Cdd:PTZ00419 347 ---INENG-----GEFAGM-HRFDCRRKIEEelkemglLRDkvpnpmrlprcSRSGdivepmlipQWYVNckdmakrave 417
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1236882790 416 ------------------YR----LRDWGVSRQRYWGAPIP 434
Cdd:PTZ00419 418 avrngelkiipsshenvwYHwlenIQDWCISRQLWWGHRIP 458
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-798 |
8.39e-26 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 114.48 E-value: 8.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 11 ESHVQRHWEQTQTF-TVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAE-- 87
Cdd:PLN02843 9 EPEIQKLWEENQVYkRVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIElk 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 88 -----GAAIKNKTSPI-------DWTKANIQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSD 155
Cdd:PLN02843 89 vlqslDQEARKELTPIklrakaaKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 156 VNWCPQDFTVLAneqvidgrcwrcDSKVErksipqwfikitayadqllddldelehWPEQVKTMQRHWIGRSEGVEIRFP 235
Cdd:PLN02843 169 VHWSPSSRTALA------------EAELE---------------------------YPEGHVSKSIYVAFPVVSPSETSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 236 LDHDEKTD---LTVYSTRPDTLMGVAFIAIAP--------------DHFFSAEIAKNVPALATFIEECRHIKMAEAETAT 298
Cdd:PLN02843 210 EELEEFLPglsLAIWTTTPWTMPANAAVAVNDklqysvvevqsfseDESTSGGNKKKRPGNVLKEQQKLFLIVATDLVPA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 299 IEKK------------GID-TGFFALHPLTGKKIPIWVA-NFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAville 364
Cdd:PLN02843 290 LEAKwgvklvvlktfpGSDlEGCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLS----- 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 365 dgtepdvqkkPLIEKGRLC-HSGEFNGLSYQ-ESCDRIIDKLVDSG--------------------------TGQ----- 411
Cdd:PLN02843 365 ----------PVDDAGKFTeEAGQFSGLSVLgEGNAAVVEALDEAGsllmeeayghkypydwrtkkptifraTEQwfasv 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 412 -----------RKVNY-------RLR-------DWGVSRQRYWGAPIPMITLEDgriigTPEdqlpVILPEKTF--IKDM 464
Cdd:PLN02843 435 egfrqaaldaiDKVKWipaqgenRIRamvsgrsDWCISRQRTWGVPIPVFYHVE-----TKE----PLMNEETIahVKSI 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 465 INpLKADQDWAKTSVAGQLG----------IRETDTFDTFIES--SWyyaryacpkydQGMIEKAAANYWlPVDQYVGGI 532
Cdd:PLN02843 506 VA-QKGSDAWWYMDVEDLLPekyrdkasdyEKGTDTMDVWFDSgsSW-----------AGVLGSREGLSY-PADLYLEGS 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 533 EHaimHLLYFRffhklmrdQGLVDS-----KEPAKRLLCQGMVLadafyynaqngervwvsptevtverDNKGQflnafd 607
Cdd:PLN02843 573 DQ---HRGWFQ--------SSLLTSvatkgKAPYKSVLTHGFVL-------------------------DEKGF------ 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 608 aqgrdlihagmsKMSKSKNNGIDPQAIVE---------KYGADTVRLFMmfAS-------APEMTLEWQESgleGAYRFL 671
Cdd:PLN02843 611 ------------KMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWV--ASvdytgdvLIGPQILKQMS---DIYRKL 673
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 672 KRLWRFV------FDhviqgPTQPLKKENLNSTQKNLRRNLHKTIAKVTDDIGRRQTFN-TAIA---AIMELMN------ 735
Cdd:PLN02843 674 RGTLRYLlgnlhdWK-----PDNAVPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKiFQILqrfTIVDLSNfyldva 748
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1236882790 736 --QLYRAPTNTEQDRA---LIQEACISVIKMLYPFTPHISFILWQHLHQSPDETHPLNIDDSLWPVVD 798
Cdd:PLN02843 749 kdRLYVGGTTSFTRRScqtVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESVFEAGWPTPN 816
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
33-199 |
2.69e-25 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 111.36 E-value: 2.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 33 EKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQL 112
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 113 QSLGFAYD-WSRelTSCkPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQD--F-------------------------- 163
Cdd:COG0143 81 EKLGISFDnFIR--TTS-PEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECerFlpdryvegtcpkcgaedaygdqcenc 157
|
170 180 190
....*....|....*....|....*....|....*..
gi 1236882790 164 -TVLANEQVIDGRCWRCDSKVERKSIPQWFIKITAYA 199
Cdd:COG0143 158 gATLEPTELINPRSAISGAPPELREEEHYFFRLSKYQ 194
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
41-231 |
1.56e-23 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 103.91 E-value: 1.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 41 WPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYD 120
Cdd:pfam09334 7 LPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKKFNISFD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 121 WSRELTSckPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLANEQV----------------------------- 171
Cdd:pfam09334 87 DYGRTTS--ERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVegtcphcgsedargdqcencgrhleptel 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1236882790 172 IDGRCWRCDSKVERKSIPQWFIKITAYADQLLD-DLDELEHWPEQVKTMQRHWIgrSEGVE 231
Cdd:pfam09334 165 INPKCVICGTTPEVKETEHYFFDLSKFQDKLREwIEENNPEWPENVKNMVLEWL--KEGLK 223
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
42-199 |
4.37e-23 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 104.19 E-value: 4.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 42 PYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYD- 120
Cdd:PRK11893 10 YYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALNISYDd 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 121 WSRelTScKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLANEQVIDG--RCWRCDSKVERKSIPQWFIKITAY 198
Cdd:PRK11893 90 FIR--TT-DPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDgyRCPPTGAPVEWVEEESYFFRLSKY 166
|
.
gi 1236882790 199 A 199
Cdd:PRK11893 167 Q 167
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
34-224 |
1.20e-22 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 99.91 E-value: 1.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 34 KYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQ 113
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 114 SLGFAYD-WSReltSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLAneqvidgrcwrcdskvERKSIPQWF 192
Cdd:cd00814 81 WLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYF 141
|
170 180 190
....*....|....*....|....*....|....
gi 1236882790 193 IKITAYADQLLD--DLDELEHWPEQVKTMQRHWI 224
Cdd:cd00814 142 FRLSKFQDRLLEwlEKNPDFIWPENARNEVLSWL 175
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
42-197 |
1.39e-20 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 93.84 E-value: 1.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 42 PYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIK--NKTSPIDWTK---------------AN 104
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKelGISGKKDIEKmgiaefnakcrefalRY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 105 IQYMKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWcPqdftvlaneqVIdgrcwrcdskve 184
Cdd:cd00818 90 VDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------LI------------ 146
|
170
....*....|...
gi 1236882790 185 RKSIPQWFIKITA 197
Cdd:cd00818 147 YRATPQWFIRVTK 159
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-795 |
2.92e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 96.55 E-value: 2.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 11 ESHVQRHWEQTQTFTVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFG------- 83
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqlvv 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 84 ---LPAEGAAiKNKTSPIDWTKANIQYMKK-------QLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKT 153
Cdd:PLN02943 146 ekmLASEGIK-RTDLGRDEFTKRVWEWKEKyggtitnQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGS 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 154 SDVNWCPQDFTVLAneqvidgrcwrcDSKVERKSIPQwfikiTAYadqllddldelehwpeqvktmqrhwigrsegvEIR 233
Cdd:PLN02943 225 YMVNWSPNLQTAVS------------DLEVEYSEEPG-----TLY--------------------------------YIK 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 234 FPLDHDEKTDLTVYSTRPDTLMGVAFIAIAPdhffsaeiaknvpalatfiEECRHIKMaeaetatiekkgidTGFFALHP 313
Cdd:PLN02943 256 YRVAGGSEDFLTIATTRPETLFGDVAIAVNP-------------------EDDRYSKY--------------IGKMAIVP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 314 LT-GKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAViLLEDGTEPDVQkkpliekgrlchsgefnGLS 392
Cdd:PLN02943 303 MTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNV-MNKDGTLNEVA-----------------GLY 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 393 YQESCDRIIDKLVDSGTGQRKVNYRLRdwgVSRQRYWGAPI-PMIT---------LEDGRIIGTPEDQLpVILPEKtFIK 462
Cdd:PLN02943 365 WFEAREKLWSDLEETGLAVKKEPHTLR---VPRSQRGGEVIePLVSkqwfvtmepLAEKALKAVENGEL-TIIPER-FEK 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 463 DMINPLKADQDWAktsVAGQL--GIRETdtfDTFIESSWYYARYACPKYDQGMIEKAAANYWLPVDQYvggiEHAIMHLL 540
Cdd:PLN02943 440 IYNHWLSNIKDWC---ISRQLwwGHRIP---VWYIVGKDCEEDYIVARSAEEALEKAREKYGKDVEIY----QDPDVLDT 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 541 YFRFFHKLMRDQGLVD-SKEPAKRLLCQGMVLAD---AFYYNAqngeRVWVSPTEVTVERDNKGQFLNAF--DAQGRdli 614
Cdd:PLN02943 510 WFSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGhdiLFFWVA----RMVMMGIEFTGTVPFSYVYLHGLirDSQGR--- 582
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 615 hagmsKMSKSKNNGIDPQAIVEKYGADTVRLFMMFASAPEmTLEWQESGLEGAYRFLKRLW---RFVFDHViqgPTQP-- 689
Cdd:PLN02943 583 -----KMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQ-DLNLSTERLTSNKAFTNKLWnagKFVLQNL---PSQSdt 653
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 690 -----LKKENLNSTQKNLR---------RNLHKTIAKVTDDIgRRQTFNTAIAAIMELM-------------NQLYRAPT 742
Cdd:PLN02943 654 sawehILACKFDKEESLLSlplpecwvvSKLHELIDSVTTSY-DKYFFGDVGREIYDFFwsdfadwyieaskTRLYHSGD 732
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 1236882790 743 NT--EQDRALIQEACISVIKMLYPFTPHISFILWQHLhqsPDETHPLNIddSLWP 795
Cdd:PLN02943 733 NSalSRAQAVLLYVFENILKLLHPFMPFVTEELWQAL---PYRKEALIV--SPWP 782
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
11-785 |
1.79e-18 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 90.94 E-value: 1.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 11 ESHVQRHWEQTQTF--TVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEG 88
Cdd:PLN02882 14 EEKILSLWSEIDAFktQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 89 A-----AIKNKTSPIDW--TKAN-------IQYMK---KQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYK 151
Cdd:PLN02882 94 EidkklGIKRRDDVLKMgiDKYNeecrsivTRYSKeweKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 152 KTSDVNWCPQDFTVLANEQVidgrcwrcdsKVERKSIPQwfikitayadqllddldelehwPEqvktmqrhwigrsegVE 231
Cdd:PLN02882 174 GFKVMPYSTACKTPLSNFEA----------GLNYKDVSD----------------------PA---------------VM 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 232 IRFPL-DHDEKTDLTVYSTRPDTLmgVAFIAIAPDHFFSAEIAKNVPALATFI-EECRhikMAEAETATIE-KKGIDT-- 306
Cdd:PLN02882 207 VSFPIvGDPDNASFVAWTTTPWTL--PSNLALCVNPNFTYVKVRNKYTGKVYIvAESR---LSALPTAKPKsKKGSKPen 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 307 ---GFFAL-----HPLTGKKI-PIW-------------VA-NFVLMEYGTGAVMGVPGHDQRDWEFATQYHLPIKAVILL 363
Cdd:PLN02882 282 aaeGYEVLakvpgSSLVGKKYePLFdyfsefsdtafrvVAdDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLP 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 364 ----EDG--TEPDVQ-------------------KKPLIEKGRLCHSGEF-----NGLSYQE------SCDRIIDKLVDS 407
Cdd:PLN02882 362 vpvdDDGcfTEKVTDfsgryvkdadkdiiaaikaKGRLVKSGSITHSYPFcwrsdTPLIYRAvpswfvKVEEIKDRLLEN 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 408 GTGQRKV-NY----RL-------RDWGVSRQRYWGAPIPMITLEDG---RIIGTPEDqlpviLPEKTFIK-DMINPLKAD 471
Cdd:PLN02882 442 NKQTYWVpDYvkekRFhnwlenaRDWAVSRSRFWGTPLPIWISDDGeevVVIGSIAE-----LEKLSGVKvTDLHRHFID 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 472 QDWAKTSVAGQLGI--RETDTFDTFIES-SWYYARYACPKYDQGMIEKAaanywLPVDQYVGGIEHAimhllyfR-FFHK 547
Cdd:PLN02882 517 HITIPSSRGPEFGVlrRVDDVFDCWFESgSMPYAYIHYPFENKELFEKN-----FPADFVAEGLDQT-------RgWFYT 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 548 LM-RDQGLVDskEPA-KRLLCQGMVLADafyynaqngervwvsptevtverDNKgqflnafdaqgrdlihagmsKMSKSK 625
Cdd:PLN02882 585 LMvLSTALFD--KPAfKNLICNGLVLAE-----------------------DGK--------------------KMSKSL 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 626 NNGIDPQAIVEKYGADTVRLFMMfaSAPEM---TLEWQESGLEG-----------AYRFL----KRLwrfvfDHVIQGPT 687
Cdd:PLN02882 620 KNYPDPNEVIDKYGADALRLYLI--NSPVVraePLRFKEEGVFGvvkdvflpwynAYRFLvqnaKRL-----EVEGGAPF 692
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 688 QPLKKENLNSTQKNLRRNLHKT----IAKVTDDIGRRQTFnTAIAAIMELMNQLyrapTNT--------------EQD-- 747
Cdd:PLN02882 693 VPLDLAKLQNSANVLDRWINSAtqslVKFVREEMGAYRLY-TVVPYLVKFIDNL----TNIyvrfnrkrlkgrtgEEDcr 767
|
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 1236882790 748 RAL--IQEACISVIKMLYPFTPHISFILWQHLHQ----SPDETH 785
Cdd:PLN02882 768 TALstLYNVLLTSCKVMAPFTPFFTEVLYQNLRKvlpgSEESIH 811
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
18-440 |
3.47e-17 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 86.88 E-value: 3.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 18 WEQTQTFTVKEDPKKEKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSP 97
Cdd:PLN02381 113 WEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRE 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 98 IDWTKANI--------------QY---MKKQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWcp 160
Cdd:PLN02381 193 RHLTRHDIgreefvsevwkwkdEYggtILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNW-- 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 161 qDFTVlaneqvidgRCWRCDSKVERKSIPQ-WFIKITAYAdqllddldelehwpEQVKTmqrhwigrseGVEIRF--PLD 237
Cdd:PLN02381 271 -DCTL---------RTAISDVEVDYIDIKErTLLKVPGYD--------------KPVEF----------GVLTSFayPLE 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 238 HDeKTDLTVYSTRPDTLMGVAFIAIAPDHffsaeiaknvpalatfiEECRHIKmaeaetatiekkgidtGFFALHPLTGK 317
Cdd:PLN02381 317 GG-LGEIVVATTRIETMLGDTAIAIHPDD-----------------ERYKHLH----------------GKFAVHPFNGR 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 318 KIPIwVANFVLME--YGTGAVMGVPGHDQRDWEFATQYHLPIkAVILLEDG----------------TEPDVQKKPLIEK 379
Cdd:PLN02381 363 KLPI-ICDAILVDpnFGTGAVKITPAHDPNDFEVGKRHNLEF-INIFTDDGkinsnggsefagmprfAAREAVIEALQKK 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 380 G----------RLCHSGEFNGL-------SYQESCDRIIDKLVDSGTGQRKVN------------YR----LRDWGVSRQ 426
Cdd:PLN02381 441 GlyrgaknnemRLGLCSRTNDVvepmikpQWFVNCSSMAKQALDAAIDGENKKlefipkqylaewKRwlenIRDWCISRQ 520
|
490
....*....|....*.
gi 1236882790 427 RYWGAPIPM--ITLED 440
Cdd:PLN02381 521 LWWGHRIPAwyVTLED 536
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-224 |
3.95e-16 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 82.89 E-value: 3.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 42 PYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSP---IDWTKANIqymKKQLQSLGFA 118
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPeelIARYHAEH---KRDFAGFGIS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 119 YD-WSRelTScKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQD--F---------------------------TVLAN 168
Cdd:PRK00133 88 FDnYGS--TH-SEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKgmFlpdrfvkgtcpkcgaedqygdncevcgATYSP 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1236882790 169 EQVIDGRCWRCDSKVERKSIPQWFIKITAYADQLLDDLDELEHWPEQVKTMQRHWI 224
Cdd:PRK00133 165 TELINPKSAISGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
700-826 |
1.79e-15 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 73.98 E-value: 1.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 700 KNLRRNLHKTIAKVTDDIGRRQtFNTAIAAIMELM-NQLY---------RAPTNTEQDRA--LIQEACISVIKMLYPFTP 767
Cdd:pfam08264 2 RWILSRLNKLIKEVTEAYENYR-FNTAAQALYEFFwNDLSdwylelikdRLYGEEPDSRAqtTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1236882790 768 HISFILWQHLHqspdethplnIDDSLWPVVDQNALIEDETLV-----VIQINGKMRAKITVPMN 826
Cdd:pfam08264 81 FITEELWQKES----------IHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKS 134
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
11-853 |
3.10e-14 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 77.31 E-value: 3.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 11 ESHVQRHWEQTQTFTVKEDPKKEK--YYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEG 88
Cdd:PTZ00427 78 EEKVLKYWKSIDAFNTSNKLAKNKkaYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEY 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 89 AAIK--NKTSPIDWTKANI------------QYMK---KQLQSLGFAYDWSRELTSCKPEYYRWEQWFFTQLYEKGLVYK 151
Cdd:PTZ00427 158 EIEKenNINKKEDILKMGIdvynekcrgivlKYSNewvKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 152 KTSDVNWCPQDFTVLANEQVidgrcwrcdsKVERKSIPQWFIKITAYADQLLDDLDELEHWPEQVKTMQRHWI-----GR 226
Cdd:PTZ00427 238 SFKVMPYSCKCNTPISNFEL----------NLNYKDTPDPSIIISFVLCSDFPKVEEECNIEEDKQLLGEKYSvlynnKR 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 227 SEGVE--------IRFPLDhdekTDLTVYSTRPDTLMGVAFIAIApDHFFSAEIAKNVPALATFIEECR----------- 287
Cdd:PTZ00427 308 ENSNNgnnnstnnVCYAQH----SEILAWTTTPWTLPSNLALCVN-EHFTYLRIHHVKSNRVVIVGECRlewimkelkwn 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 288 --HIKMAE----AETATIEKKGIDTGFFALHPLTGKKIPIWVANFVLMEYGTGAVMGVPGHDQRDWEFATQYHL------ 355
Cdd:PTZ00427 383 veDLKIVNrfkgKELKGLRYKPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidpekn 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 356 ----PIKA-------VILLED---GTEPDVQKKPLIEKGRL------CHSGEFNGLSYQESCDRII-----------DKL 404
Cdd:PTZ00427 463 ifidPLDAngyftneVEEVQNlyiKEADNVIKKKLKNENRLlsnntiVHSYPFCWRSDTPLIYRAIpawfirvsnstNEL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 405 VDSGTGQRKVNYRL------------RDWGVSRQRYWGAPIPMITLEDGRIIGTPE-----DQLPVILPEKTFIKDMINP 467
Cdd:PTZ00427 543 VKNNETTYWIPAHIkekkfhnwikdaKDWCISRNRYWGTPIPIWADEKMETVICVEsikhlEELSGVKNINDLHRHFIDH 622
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 468 LKADQDWAKTSVAGQlgiRETDTFDTFIES-SWYYARYACPKydqgMIEKAAANYWLPVDQYVGGIEHAimhllyFRFFH 546
Cdd:PTZ00427 623 IEIKNPKGKTYPKLK---RIPEVFDCWFESgSMPYAKVHYPF----STEKEDFHKIFPADFIAEGLDQT------RGWFY 689
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 547 KLMRDQGLVDSKEPAKRLLCQGMVLADafyynaqngervwvsptevtverDNKgqflnafdaqgrdlihagmsKMSKSKN 626
Cdd:PTZ00427 690 TLLVISTLLFDKAPFKNLICNGLVLAS-----------------------DGK--------------------KMSKRLK 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 627 NGIDPQAIVEKYGADTVRLFMMFASAPEM-TLEWQESGL-EGAYRFLKRLW---RFVFDHVIQGPTQPLKK--------- 692
Cdd:PTZ00427 727 NYPDPLYILDKYGADSLRLYLINSVAVRAeNLKFQEKGVnEVVKSFILPFYhsfRFFSQEVTRYECLNKKQflfntdyiy 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 693 ENLNSTQKNLRRNLHKTIAKVTDDIGRRQTFNTaIAAIMELMNQLYRAPTNTEQDR---ALIQEACISVIKMLY------ 763
Cdd:PTZ00427 807 KNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNV-LPKLLQFIENLTNWYIRLNRDRmrgSLGEENCLQSLCTTYrtlhlf 885
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 764 -----PFTPHISFILWQHL--------HQSPDET-----HPLNIDDS-------LWPVVDQNALIEDETLVVIQingKMR 818
Cdd:PTZ00427 886 tvlmaPFTPFITEYIYQQLrrvkstneHNENNETgntkeGDLNRGVIhksvhfiMLPQVDEKYIIDYEIIELIE---KMK 962
|
970 980 990
....*....|....*....|....*....|....*
gi 1236882790 819 AKITVPMNstQQEVYESALQEPtvikhLKGITPCH 853
Cdd:PTZ00427 963 DVILLGRV--LRERRKVASKKP-----LKSITILH 990
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
620-796 |
8.37e-11 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 65.52 E-value: 8.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 620 KMSKSKNNGIDPQAIVEKYGADTVRLFMMfASAPEM---TLEWQE------SGLEGAY-RFLKRLWRFV---FDHVIQGP 686
Cdd:COG0143 327 KMSKSRGNVIDPDDLLDRYGPDALRYYLL-REVPFGqdgDFSWEDfvarvnSDLANDLgNLASRTLSMIhkyFDGKVPEP 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 687 tqplkkENLNSTQKNLRRNLHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNQlY---RAP--TNTEQDRALIQEAC--- 755
Cdd:COG0143 406 ------GELTEADEELLAEAEAALEEVAEAMEAFE-FRKALEEIMALaraANK-YideTAPwkLAKDEDPERLATVLytl 477
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1236882790 756 ISVIK----MLYPFTPHISFILWQHLHQSPDEthpLNIDDSLWPV 796
Cdd:COG0143 478 LEALRilaiLLKPFLPETAEKILEQLGLEGDE---LTWEDAGWPL 519
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
614-762 |
1.35e-10 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 64.35 E-value: 1.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 614 IHAGM-----SKMSKSKNNGIDPQAIVEKYGADTVRLFMMFA---SapemTLEWQESGLEGAYRFLKRLWRFVFDHVIQG 685
Cdd:COG0215 254 MHNGFltvngEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyrS----PLDFSEEALEEAEKALERLYNALRRLEEAL 329
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1236882790 686 PTQPLKKENLNSTQKnlrrnlhKTIAKVTDDigrrqtFNT--AIAAIMELMNQLYRApTNTEQDRALIQEACISVIKML 762
Cdd:COG0215 330 GAADSSAEEIEELRE-------EFIAAMDDD------FNTpeALAVLFELVREINKA-LDEGEDKAALAALAALLRALG 394
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
620-784 |
2.18e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 64.13 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 620 KMSKSKNNGIDPQAIVEKYGADTVRLFMMfASAPEmtlewqesGLEGAYRfLKRLWRFV-------FDHVIQGPTQPLKK 692
Cdd:PRK11893 299 KMSKSLGNVIDPFDLVDEYGVDAVRYFLL-REIPF--------GQDGDFS-REAFINRInadlandLGNLAQRTLSMIAK 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 693 ---------ENLNSTQKNLRRNLHKTIAKVTDDIGRRQtFNTAIAAIMELMNQLYR--------APTNTEQDR-ALIQEA 754
Cdd:PRK11893 369 nfdgkvpepGALTEADEALLEAAAALLERVRAAMDNLA-FDKALEAILALVRAANKyideqapwSLAKTDPERlATVLYT 447
|
170 180 190
....*....|....*....|....*....|....
gi 1236882790 755 CISVIK----MLYPFTPHISFILWQHLHQSPDET 784
Cdd:PRK11893 448 LLEVLRgiavLLQPVMPELAAKILDQLGVEEDEN 481
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
43-199 |
2.99e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 64.05 E-value: 2.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 43 YPSGRLHMGHVrnYT--ITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYD 120
Cdd:PRK12267 14 YPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKELWKKLDISYD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 121 WSRELTSckPEYYRWEQWFFTQLYEKGLVYKKTSDVNWCPQDFTVLANEQVID-GRCWRCDSKVERKSIPQWFIKITAYA 199
Cdd:PRK12267 92 KFIRTTD--ERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDgGKCPDCGREVELVKEESYFFRMSKYQ 169
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
620-784 |
2.21e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 60.97 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 620 KMSKSKNNGIDPQAIVEKYGADTVRLFMMfasaPEMTLewqesGLEGAY---RFLKR------------LWRFV------ 678
Cdd:PRK12267 299 KMSKSKGNVVDPEELVDRYGLDALRYYLL----REVPF-----GSDGDFspeALVERinsdlandlgnlLNRTVaminky 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 679 FDHVIQGPTQPLKKENlnstqkNLRRNLHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNQ---------LYRAPTNTEQ 746
Cdd:PRK12267 370 FDGEIPAPGNVTEFDE------ELIALAEETLKNYEELMEELQ-FSRALEEVWKLisrANKyidetapwvLAKDEGKKER 442
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1236882790 747 DRALIQEACISVIK---MLYPFTPHISFILWQHLHQSPDET 784
Cdd:PRK12267 443 LATVMYHLAESLRKvavLLSPFMPETSKKIFEQLGLEEELT 483
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
9-92 |
4.68e-09 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 60.47 E-value: 4.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 9 DIESHVQRHWEQTQTFTV---KEDPKK-EKYYCLAMWPYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGL 84
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAeagDEPPKPgEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGM 96
|
....*...
gi 1236882790 85 PAEGAAIK 92
Cdd:PLN02959 97 PIKASADK 104
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
661-777 |
2.31e-06 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 47.55 E-value: 2.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 661 ESGLEGAYRFLKRLW---RFVFDHVIQGPTQPLKKENLNSTQKNLRRNLHKTIAKVTDDIGRRQtFNTAIAAI------- 730
Cdd:cd07962 3 EKRVEGGRNFCNKLWnaaRFVLMNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYR-FSEAATALyeffwnd 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1236882790 731 -----MELMNQLYRAPTNTEQD--RALIQEACISVIKMLYPFTPHISFILWQHL 777
Cdd:cd07962 82 fcdwyLELVKPRLYGEDEEEKKaaRATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
661-766 |
4.16e-06 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 46.73 E-value: 4.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 661 ESGLEGAYRFLKRLWRFV-FDHVIQGPTQP-LKKENLNSTQKNLRRNLHKTIAKVTDDIgRRQTFNTAIAAIMELMNQLY 738
Cdd:cd07375 1 EERLKQARAFLNRLYRLLsFFRKALGGTQPkWDNELLEEADRELLARLQEFIKRTTNAL-EALDPTTAVQELFKFTNELN 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 1236882790 739 R----------APTNTEQDRALIQEACISVIKMLYPFT 766
Cdd:cd07375 80 WyldelkpalqTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
43-159 |
8.19e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 46.25 E-value: 8.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 43 YPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSLGFAYDws 122
Cdd:PLN02224 79 YVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIISQSYRTLWKDLDIAYD-- 156
|
90 100 110
....*....|....*....|....*....|....*..
gi 1236882790 123 RELTSCKPEYYRWEQWFFTQLYEKGLVYKKTSDVNWC 159
Cdd:PLN02224 157 KFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYC 193
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
620-656 |
1.59e-03 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 41.89 E-value: 1.59e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1236882790 620 KMSKSKNNGIDPQAIVEKYGADTVRLFMMfASAPEMT 656
Cdd:pfam09334 324 KMSKSRGNVVWPSEALDRFPPDALRYYLA-RNRPETK 359
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
598-736 |
2.92e-03 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 41.17 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 598 NKGQFLNAFDAQGRDLIHaGMsKMSKSKNNGIDPQAIVEKYGADTVRlfMMFASAP-EMTLEWQESGLEGAYRFLKRLWR 676
Cdd:PTZ00399 295 DKHQWVNYFLHSGHLHIK-GL-KMSKSLKNFITIRQALSKYTARQIR--LLFLLHKwDKPMNYSDESMDEAIEKDKVFFN 370
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1236882790 677 FvFDHViqgpTQPLKKENLNSTQK--NLRRNLHKTIAKVTDDIGR--RQTFNT--AIAAIMELMNQ 736
Cdd:PTZ00399 371 F-FANV----KIKLRESELTSPQKwtQHDFELNELFEETKSAVHAalLDNFDTpeALQALQKLISA 431
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
659-775 |
3.76e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 37.96 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 659 WQESGLEGAYRFLKRLWRFVFDHV-IQGPTQPLKKENlnstqKNLRRNLHKTIAKVTDDIGRRQTFNTAIAAIMELMNQL 737
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIeTEGELEELTFID-----RWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDL 75
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1236882790 738 --YRAPTNTEQDRALIQEACISVIKMLYPFTPHISFILWQ 775
Cdd:cd07959 76 dwYRERGGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWH 115
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
614-651 |
4.51e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 39.48 E-value: 4.51e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1236882790 614 IHAGM-----SKMSKSKNNGIDPQAIVEKYGADTVRLFMMFAS 651
Cdd:cd00672 163 LHTGHltidgEKMSKSLGNFITVRDALKKYDPEVLRLALLSSH 205
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-126 |
9.24e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 37.46 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236882790 42 PYPSGRLHMGHVRNYTITDVIARYQRMLGKNVLQPMGWDAFGLPAEGAAIKNKTSPIDWTKANIQYMKKQLQSL-GFAYD 120
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDVEYMfLQAAD 85
|
....*.
gi 1236882790 121 WSRELT 126
Cdd:cd00802 86 FLLLYE 91
|
|
| |
