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Conserved domains on  [gi|1238701537|ref|WP_095351685|]
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lactate utilization protein B [Acetobacter syzygii]

Protein Classification

lactate utilization protein B( domain architecture ID 11439020)

lactate utilization protein B (LutB) is an iron-sulfur cluster-binding protein involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source

Gene Ontology:  GO:0051539|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 2-453 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


:

Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 696.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537   2 KVKPVNHAKAAEAFIEDTAHMDFHDERLWDLRQKRDQQMHILPEWQELRARASAIKEHTLANLPEYLEQFEANAKKNGIH 81
Cdd:COG1139     3 KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATANGGH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537  82 VHWAADGAEHNRIVGEILEKHGAKSLIKSKSMVTEECCMREYLEPRGVVVTETDLGERIQQLDAQIPSHIVVPAVHKLIP 161
Cdd:COG1139    83 VHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHKNRE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 162 DVAKIFAKHYHTDPNDDDAQSLAWQQRLAARPVILSADAGMTGGNFVVAETGSFVVCTNEGNADLSATVPGLHIATIGIE 241
Cdd:COG1139   163 QIAELFHEKLGTEPLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVMGIE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 242 RLVPRMADMGVFIRMLSRSALGSPITQYTTHFRGPQK------GSEMHVVLVDNGRSHRLGMEEFWTSLKCIRCGACMNT 315
Cdd:COG1139   243 KLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRRpgegdgPEEFHLVLLDNGRSAMLADPEFREALRCIRCGACLNV 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 316 CPVYRRSGGLSYGAVYSGPIGAIIDPTFN-ERKYSTLPFASTMNGSCTNVCPVKINIHDQLYKWRRVLAEHHELPFVKRE 394
Cdd:COG1139   323 CPVYRRVGGHAYGSVYPGPIGAVLTPLLHgLEKAADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLTPPAEKL 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238701537 395 VMYMAGKLMGQPSLYRAAINSTEVALSTMPRF----VLYNWLNPWGKHRELPHPVKQTFHSWY 453
Cdd:COG1139   403 AMKAWAWVMSNPKLYRLALRLARRALKLLPRGggirRLPGPLGGWTKGRDLPAPAKESFRDWW 465
 
Name Accession Description Interval E-value
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 2-453 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 696.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537   2 KVKPVNHAKAAEAFIEDTAHMDFHDERLWDLRQKRDQQMHILPEWQELRARASAIKEHTLANLPEYLEQFEANAKKNGIH 81
Cdd:COG1139     3 KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATANGGH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537  82 VHWAADGAEHNRIVGEILEKHGAKSLIKSKSMVTEECCMREYLEPRGVVVTETDLGERIQQLDAQIPSHIVVPAVHKLIP 161
Cdd:COG1139    83 VHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHKNRE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 162 DVAKIFAKHYHTDPNDDDAQSLAWQQRLAARPVILSADAGMTGGNFVVAETGSFVVCTNEGNADLSATVPGLHIATIGIE 241
Cdd:COG1139   163 QIAELFHEKLGTEPLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVMGIE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 242 RLVPRMADMGVFIRMLSRSALGSPITQYTTHFRGPQK------GSEMHVVLVDNGRSHRLGMEEFWTSLKCIRCGACMNT 315
Cdd:COG1139   243 KLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRRpgegdgPEEFHLVLLDNGRSAMLADPEFREALRCIRCGACLNV 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 316 CPVYRRSGGLSYGAVYSGPIGAIIDPTFN-ERKYSTLPFASTMNGSCTNVCPVKINIHDQLYKWRRVLAEHHELPFVKRE 394
Cdd:COG1139   323 CPVYRRVGGHAYGSVYPGPIGAVLTPLLHgLEKAADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLTPPAEKL 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238701537 395 VMYMAGKLMGQPSLYRAAINSTEVALSTMPRF----VLYNWLNPWGKHRELPHPVKQTFHSWY 453
Cdd:COG1139   403 AMKAWAWVMSNPKLYRLALRLARRALKLLPRGggirRLPGPLGGWTKGRDLPAPAKESFRDWW 465
TIGR00273 TIGR00273
iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding ...
 32-410 3.98e-124

iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulfur clusters. [Energy metabolism, Electron transport]


Pssm-ID: 129374 [Multi-domain]  Cd Length: 432  Bit Score: 368.43  E-value: 3.98e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537  32 LRQKRDQQMHILPEWQELRARASAIKEHTLANLPEYLEQFEANAKKNGIHVHWAADGAEHNRIVGEILEKHGAKSLIKSK 111
Cdd:TIGR00273  17 LRANRKLLVEELGYWEEWRELVKEIKLKVLENLDFYLDQLKENVTQRGGHVYYAKTAEEARKIIGKVAQEKNGKKVVKSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 112 SMVTEECCMREYLEPRGVVVTETDLGERIQQLDAQIPSHIVVPAVHKLIPDVAKIFAKHYHTDpNDDDAQSLAWQQRLAA 191
Cdd:TIGR00273  97 SMVSEEIGLNEVLEKIGIEVWETDLGELILQLDGDPPSHIVVPALHKNRQQIGEILKERLGYE-GEESPEVLAREARKFM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 192 RPVILSADAGMTGGNFVVAETGSFVVCTNEGNADLSATVPGLHIATIGIERLVPRMADMGVFIRMLSRSALGSPITQYTT 271
Cdd:TIGR00273 176 REKFLSADIGISGCNFAIAETGSIFLVENEGNGRLSTTLPKTHIAVMGIEKIVPTFDDELVLKSMLARSAVGTRLTAYIN 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 272 HFRGPQK------GSEMHVVLVDNGRSHRLGmEEFWTSLKCIRCGACMNTCPVYRRSGGLSYGAVYSGPIGAIIDP-TFN 344
Cdd:TIGR00273 256 VLTGPRQegdvdgPEEFHLILLDNGRSNILA-TEFREVLACIRCGACQNECPVYRHIGGHWYGSIYPGPIGAVWSPlLGG 334

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238701537 345 ERKYSTLPFASTMNGSCTNVCPVKINIHDQLYKWRRVLAEHHELPFVKREVMYMAGKLMGQPSLYR 410
Cdd:TIGR00273 335 YTDYKHLPYLSSLCGACREVCPVKIPLPELIREHRSDKVEKGRHSGMEKLAMKMFAKMASDGALWK 400
LUD_dom pfam02589
LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and ...
 68-287 5.18e-39

LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate


Pssm-ID: 426855  Cd Length: 188  Bit Score: 139.67  E-value: 5.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537  68 LEQFEANAKKNGIHVHWAADGAEHNRIVGEILEKHGAksliksksmvteeccmreyleprGVVVTETDLGERIqqldaqi 147
Cdd:pfam02589   1 LEEFKENLEANGAEVYYAKTAEEALEYILELIKEGGV-----------------------VSEGGSTDLGELG------- 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 148 pshiVVPAVHKLIPDVAKIFAKhyhtdpndddaqSLAWQQRLAARPVILSADAGMTGGNFVVAETGSFVVCTNEGNADLS 227
Cdd:pfam02589  51 ----LAPALHSGRYEVLDLFEE------------KLTAEAREELREKALTADVGITGANFAIAETGTLVLVDGEGNRRLL 114

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1238701537 228 ATVPGLHIATIGIERLVPRMADMGVFIRMLSRSALGSPITQYTTHFRGPQK--------------GSEMHVVLV 287
Cdd:pfam02589 115 SFLPKVHIAVVGINKIVPDLEDAVKRLRLAPRNATRQKLTPYITFISGPSRtadielvlvvgvhgPGELHVILV 188
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 305-369 2.69e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 40.84  E-value: 2.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238701537 305 KCIRCGACMNTCPVyrrsgglsyGAVYSGPIGAII-DPTFNERKystlpfaSTMNGSCTNVCPVKI 369
Cdd:cd10549     7 KCIGCGICVKACPT---------DAIELGPNGAIArGPEIDEDK-------CVFCGACVEVCPTGA 56
 
Name Accession Description Interval E-value
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 2-453 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 696.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537   2 KVKPVNHAKAAEAFIEDTAHMDFHDERLWDLRQKRDQQMHILPEWQELRARASAIKEHTLANLPEYLEQFEANAKKNGIH 81
Cdd:COG1139     3 KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATANGGH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537  82 VHWAADGAEHNRIVGEILEKHGAKSLIKSKSMVTEECCMREYLEPRGVVVTETDLGERIQQLDAQIPSHIVVPAVHKLIP 161
Cdd:COG1139    83 VHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHKNRE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 162 DVAKIFAKHYHTDPNDDDAQSLAWQQRLAARPVILSADAGMTGGNFVVAETGSFVVCTNEGNADLSATVPGLHIATIGIE 241
Cdd:COG1139   163 QIAELFHEKLGTEPLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVMGIE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 242 RLVPRMADMGVFIRMLSRSALGSPITQYTTHFRGPQK------GSEMHVVLVDNGRSHRLGMEEFWTSLKCIRCGACMNT 315
Cdd:COG1139   243 KLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRRpgegdgPEEFHLVLLDNGRSAMLADPEFREALRCIRCGACLNV 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 316 CPVYRRSGGLSYGAVYSGPIGAIIDPTFN-ERKYSTLPFASTMNGSCTNVCPVKINIHDQLYKWRRVLAEHHELPFVKRE 394
Cdd:COG1139   323 CPVYRRVGGHAYGSVYPGPIGAVLTPLLHgLEKAADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLTPPAEKL 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238701537 395 VMYMAGKLMGQPSLYRAAINSTEVALSTMPRF----VLYNWLNPWGKHRELPHPVKQTFHSWY 453
Cdd:COG1139   403 AMKAWAWVMSNPKLYRLALRLARRALKLLPRGggirRLPGPLGGWTKGRDLPAPAKESFRDWW 465
TIGR00273 TIGR00273
iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding ...
 32-410 3.98e-124

iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulfur clusters. [Energy metabolism, Electron transport]


Pssm-ID: 129374 [Multi-domain]  Cd Length: 432  Bit Score: 368.43  E-value: 3.98e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537  32 LRQKRDQQMHILPEWQELRARASAIKEHTLANLPEYLEQFEANAKKNGIHVHWAADGAEHNRIVGEILEKHGAKSLIKSK 111
Cdd:TIGR00273  17 LRANRKLLVEELGYWEEWRELVKEIKLKVLENLDFYLDQLKENVTQRGGHVYYAKTAEEARKIIGKVAQEKNGKKVVKSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 112 SMVTEECCMREYLEPRGVVVTETDLGERIQQLDAQIPSHIVVPAVHKLIPDVAKIFAKHYHTDpNDDDAQSLAWQQRLAA 191
Cdd:TIGR00273  97 SMVSEEIGLNEVLEKIGIEVWETDLGELILQLDGDPPSHIVVPALHKNRQQIGEILKERLGYE-GEESPEVLAREARKFM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 192 RPVILSADAGMTGGNFVVAETGSFVVCTNEGNADLSATVPGLHIATIGIERLVPRMADMGVFIRMLSRSALGSPITQYTT 271
Cdd:TIGR00273 176 REKFLSADIGISGCNFAIAETGSIFLVENEGNGRLSTTLPKTHIAVMGIEKIVPTFDDELVLKSMLARSAVGTRLTAYIN 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 272 HFRGPQK------GSEMHVVLVDNGRSHRLGmEEFWTSLKCIRCGACMNTCPVYRRSGGLSYGAVYSGPIGAIIDP-TFN 344
Cdd:TIGR00273 256 VLTGPRQegdvdgPEEFHLILLDNGRSNILA-TEFREVLACIRCGACQNECPVYRHIGGHWYGSIYPGPIGAVWSPlLGG 334

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238701537 345 ERKYSTLPFASTMNGSCTNVCPVKINIHDQLYKWRRVLAEHHELPFVKREVMYMAGKLMGQPSLYR 410
Cdd:TIGR00273 335 YTDYKHLPYLSSLCGACREVCPVKIPLPELIREHRSDKVEKGRHSGMEKLAMKMFAKMASDGALWK 400
LUD_dom pfam02589
LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and ...
 68-287 5.18e-39

LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate


Pssm-ID: 426855  Cd Length: 188  Bit Score: 139.67  E-value: 5.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537  68 LEQFEANAKKNGIHVHWAADGAEHNRIVGEILEKHGAksliksksmvteeccmreyleprGVVVTETDLGERIqqldaqi 147
Cdd:pfam02589   1 LEEFKENLEANGAEVYYAKTAEEALEYILELIKEGGV-----------------------VSEGGSTDLGELG------- 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 148 pshiVVPAVHKLIPDVAKIFAKhyhtdpndddaqSLAWQQRLAARPVILSADAGMTGGNFVVAETGSFVVCTNEGNADLS 227
Cdd:pfam02589  51 ----LAPALHSGRYEVLDLFEE------------KLTAEAREELREKALTADVGITGANFAIAETGTLVLVDGEGNRRLL 114

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1238701537 228 ATVPGLHIATIGIERLVPRMADMGVFIRMLSRSALGSPITQYTTHFRGPQK--------------GSEMHVVLV 287
Cdd:pfam02589 115 SFLPKVHIAVVGINKIVPDLEDAVKRLRLAPRNATRQKLTPYITFISGPSRtadielvlvvgvhgPGELHVILV 188
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 305-369 8.62e-14

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 65.80  E-value: 8.62e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1238701537 305 KCIRCGACMNTCPVYRRSGGLSYGAVYSGPIGAIIDPTFNERKYSTLpFASTMNGSCTNVCPVKI 369
Cdd:pfam13183   1 RCIRCGACLAACPVYLVTGGRFPGDPRGGAAALLGRLEALEGLAEGL-WLCTLCGACTEVCPVGI 64
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 305-402 4.24e-09

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 58.16  E-value: 4.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 305 KCIRCGACMNTCPVYRRSGGLSYG---------AVYSGPigaiIDPTFNERKYSTLpFASTMNGSCTNVCPVKINIHDQL 375
Cdd:COG0247    79 ACVGCGFCRAMCPSYKATGDEKDSprgrinllrEVLEGE----LPLDLSEEVYEVL-DLCLTCKACETACPSGVDIADLI 153

                          90       100
                  ....*....|....*....|....*..
gi 1238701537 376 YKWRRVLAEHHELPFVKREVMYMAGKL 402
Cdd:COG0247   154 AEARAQLVERGGRPLRDRLLRTFPDRV 180
LutC COG1556
L-lactate utilization protein LutC, contains LUD domain [Energy production and conversion];
129-267 9.50e-08

L-lactate utilization protein LutC, contains LUD domain [Energy production and conversion];


Pssm-ID: 441165  Cd Length: 206  Bit Score: 52.17  E-value: 9.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 129 VVVTETDLGERIQQ-LDAQIPSHIVVPavhklIPDVAKIFAKHYHTDPNDDDAQSLAwqqrlaarpvilSADAGMTGGNF 207
Cdd:COG1556    55 RVTTEAELPAALAElLAEAGLKRIVVP-----EPGLPAALQLAWDPLEELEDPAALE------------DADVGITGAEF 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 208 VVAETGSFVVCTNEGNADLSATVPGLHIATIGIERLVPRMADmgVFIRMLSRSALGSPIT 267
Cdd:COG1556   118 GIAETGTIVLDSGPDQGRALSLLPEHHIVVVPASQIVPTMHE--AYARLREKAGLPRNIT 175
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 305-366 6.08e-07

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 46.47  E-value: 6.08e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1238701537 305 KCIRCGACMNTCPVYRRSGGLSYGAVYSGPIgaiidptfnerkySTLPFASTMNGSCTNVCP 366
Cdd:pfam13237   8 KCIGCGRCTAACPAGLTRVGAIVERLEGEAV-------------RIGVWKCIGCGACVEACP 56
LutB_C pfam11870
Lactate utilization protein B, C-terminal; This domain is functionally uncharacterized. This ...
 389-455 8.61e-05

Lactate utilization protein B, C-terminal; This domain is functionally uncharacterized. This domain is found at the C-terminal of a family of 4Fe-4S, iron-sulphur cluster binding proteins, including Lactate utilization protein B (LutB). These proteins have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4Fe-4S iron-sulphur clusters. This domain is found in LutB proteins in association with the LUD domain (pfam02589) and usually Fer4_8 (pfam13183). The LutABC operon is involved in lactate-utilization and is essential.


Pssm-ID: 432147 [Multi-domain]  Cd Length: 86  Bit Score: 41.11  E-value: 8.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1238701537 389 PFVKREVMYMAGKLMGQPSLYRAAinstevaLSTMPRF--VLYNWLNPWGKHRELPHPVKQTFHSWYKQ 455
Cdd:pfam11870  22 SAAERLAWKGFALAASSPGLYRLG-------TWLATRFrgLLPSKLKAWTRVRTFPKPAARSLHDLAKE 83
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 282-368 1.86e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 40.03  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 282 MHVVLVDNGRShrlGMEEFWTSLKCIRCGACMNTCPVyrrsgglsyGAVYSGPIGAIIDPtfnerkystlpfaSTMN--G 359
Cdd:COG4231     3 ITVKILDNRTT---AMRYVIDEDKCTGCGACVKVCPA---------DAIEEGDGKAVIDP-------------DLCIgcG 57


                  ....*....
gi 1238701537 360 SCTNVCPVK 368
Cdd:COG4231    58 SCVQVCPVD 66
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 306-369 2.17e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.05  E-value: 2.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238701537 306 CIRCGACMNTCPVYRRSgglsygavysgpigaiIDPTFNERKYSTLPFAS---TMNGSCTNVCPVKI 369
Cdd:pfam12838   1 CIGCGACVAACPVGAIT----------------LDEVGEKKGTKTVVIDPercVGCGACVAVCPTGA 51
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 305-369 2.69e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 40.84  E-value: 2.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238701537 305 KCIRCGACMNTCPVyrrsgglsyGAVYSGPIGAII-DPTFNERKystlpfaSTMNGSCTNVCPVKI 369
Cdd:cd10549     7 KCIGCGICVKACPT---------DAIELGPNGAIArGPEIDEDK-------CVFCGACVEVCPTGA 56
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 297-385 9.42e-04

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 40.50  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 297 MEEFWTSLKCIRCGACMNTCPVYRRSGGlsygavYSGPIGA------IIDPTfNERKYSTLPFASTMNG--------SCT 362
Cdd:COG0479   135 REKADDLAECILCGACVAACPNVWANPD------FLGPAALaqayrfALDPR-DEETEERLEALEDEEGvwrcttcgNCT 207

                          90       100
                  ....*....|....*....|...
gi 1238701537 363 NVCPVKINIHDQLYKWRRVLAEH 385
Cdd:COG0479   208 EVCPKGIPPTKAIAKLKREALKR 230
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 305-368 1.07e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 37.42  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1238701537 305 KCIRCGACMNTCPVyrrsgglsygavysgpiGAI-IDPTFNERKYSTLPFASTMNGSCTNVCPVK 368
Cdd:COG1143     3 KCIGCGLCVRVCPV-----------------DAItIEDGEPGKVYVIDPDKCIGCGLCVEVCPTG 50
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 305-367 1.84e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 38.53  E-value: 1.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238701537 305 KCIRCGACMNTCPVyrrsgglsyGAVYSGPIGAIIDPTFNERKystlpfastMN-------GSCTNVCPV 367
Cdd:cd10549    41 KCVFCGACVEVCPT---------GAIELTPEGKEYVPKEKEAE---------IDeekcigcGLCVKVCPV 92
NapF COG1145
Ferredoxin [Energy production and conversion];
305-377 2.02e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 39.71  E-value: 2.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1238701537 305 KCIRCGACMNTCPVyrrsgglsygavysgpigAIIDPTFNERKYSTLPFASTMNGSCTNVCPVK-INIHDQLYK 377
Cdd:COG1145   183 KCIGCGLCVKVCPT------------------GAIRLKDGKPQIVVDPDKCIGCGACVKVCPVGaISLEPKEIE 238
Fer4_4 pfam12800
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 305-319 2.07e-03

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 463714  Cd Length: 17  Bit Score: 35.41  E-value: 2.07e-03
                          10
                  ....*....|....*
gi 1238701537 305 KCIRCGACMNTCPVY 319
Cdd:pfam12800   3 KCIGCGACVDACPYG 17
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
305-368 2.44e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 36.63  E-value: 2.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1238701537 305 KCIRCGACMNTCPVyrrsgglsygavysgpiGAIidpTFNERKYSTLPFASTMNGSCTNVCPVK 368
Cdd:COG2768    12 KCIGCGACVKVCPV-----------------GAI---SIEDGKAVIDPEKCIGCGACIEVCPVG 55
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 305-318 3.20e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 34.92  E-value: 3.20e-03
                          10
                  ....*....|....
gi 1238701537 305 KCIRCGACMNTCPV 318
Cdd:pfam00037   7 KCIGCGACVEVCPV 20
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 305-368 4.34e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 35.86  E-value: 4.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1238701537 305 KCIRCGACMNTCPvyrrsgglsYGAVYSGPIGAiidPTFNERKYSTLpfastmnGSCTNVCPVK 368
Cdd:COG1149    12 KCIGCGLCVEVCP---------EGAIKLDDGGA---PVVDPDLCTGC-------GACVGVCPTG 56
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 305-370 6.83e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 35.13  E-value: 6.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238701537 305 KCIRCGACMNTCPVYRRSGglSYGAVYsgpIGAIIDPTFNERKYSTLPFASTMNGSCTNVCPVKIN 370
Cdd:pfam13534   1 RCIQCGCCVDECPRYLLNG--DEPKKL---MRAAYLGDLEELQANKVANLCSECGLCEYACPMGLD 61
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 305-318 7.16e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.03  E-value: 7.16e-03
                          10
                  ....*....|....
gi 1238701537 305 KCIRCGACMNTCPV 318
Cdd:COG2221    45 KCIGCGACIRVCPT 58
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 305-318 7.61e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 36.61  E-value: 7.61e-03
                          10
                  ....*....|....
gi 1238701537 305 KCIRCGACMNTCPV 318
Cdd:cd10549   109 KCIGCGICAEVCPV 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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