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Conserved domains on  [gi|1243945372|ref|WP_096038752|]
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MULTISPECIES: peptide chain release factor 2 [Pseudoalteromonas]

Protein Classification

PCRF domain-containing protein( domain architecture ID 1750053)

peptide chain release factor (PCRF) domain-containing protein similar to Homo sapiens mitochondrial peptide chain release factor 1 (MTRF1), MTRF1-like and 28S mitochondrial ribosomal protein S35 (MRPS35)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCRF super family cl40670
This domain is found in peptide chain release factors;
3-365 0e+00

This domain is found in peptide chain release factors;


The actual alignment was detected with superfamily member TIGR00020:

Pssm-ID: 477417 [Multi-domain]  Cd Length: 364  Bit Score: 546.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372   3 EVNPVINQIKEIRERTELLRGYLDYALKQERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEG 82
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  83 LVELAVEAEDQDTFDEAQSELADLNQQLEGLEFRRMFSGSHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFK 162
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 163 VELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHRLVRKSPFDSSGRRHTSFASAFVYPEVDDNIEIDINPSDLRID 242
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRID 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 243 VYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELELQQQNAEKQSQEDNKSDIGWGSQ 322
Cdd:TIGR00020 241 TYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQ 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1243945372 323 IRSYVLDD-SRIKDLRTGVENRNTQAVLDGDLDKFIEASLKSGL 365
Cdd:TIGR00020 321 IRSYVLHPySMVKDLRTGYETGNVQAVLDGDIDQFIEAYLKWKL 364
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 3-365 0e+00

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 546.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372   3 EVNPVINQIKEIRERTELLRGYLDYALKQERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEG 82
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  83 LVELAVEAEDQDTFDEAQSELADLNQQLEGLEFRRMFSGSHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFK 162
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 163 VELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHRLVRKSPFDSSGRRHTSFASAFVYPEVDDNIEIDINPSDLRID 242
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRID 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 243 VYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELELQQQNAEKQSQEDNKSDIGWGSQ 322
Cdd:TIGR00020 241 TYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQ 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1243945372 323 IRSYVLDD-SRIKDLRTGVENRNTQAVLDGDLDKFIEASLKSGL 365
Cdd:TIGR00020 321 IRSYVLHPySMVKDLRTGYETGNVQAVLDGDIDQFIEAYLKWKL 364
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 63-365 4.50e-160

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 451.03  E-value: 4.50e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  63 LEAVVETIDTLVAGTDDVEGLVELAVEAEDQDTfdeAQSELADLNQ---QLEGLEFRRMFSGSHDSNDAYLDLQSGSGGT 139
Cdd:PRK08787    2 LEKTVIGIADVLSGLADAGELLDLAESEQDEDT---ALAVIADLDKyqaHVEKLEFQRMFSGQMDGANAFVDIQAGAGGT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 140 EAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHRLVRKSPFDSSGRRHTSFAS 219
Cdd:PRK08787   79 EAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 220 AFVYPEVDDNIEIDINPSDLRIDVYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELE 299
Cdd:PRK08787  159 VFVSPEVDDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELE 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1243945372 300 LQQQNAEKQSQEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVENRNTQAVLDGDLDKFIEASLKSGL 365
Cdd:PRK08787  239 VQKRNAEKDALEATKSDIGWGSQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEASLKAGL 304
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 31-359 3.38e-108

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 320.79  E-value: 3.38e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  31 QERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEAEDQDTFDEAQSELADLNQQL 110
Cdd:COG0216    10 EERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELEARL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 111 EGLEFR-------RmfsgshDSND---AYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGAT 180
Cdd:COG0216    90 EELEEElkilllpK------DPNDdknVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 181 VRFSGEYAYGWLRTETGVHRlVRKSP-FDSSGRRHTSFASAFVYPEVDDnIEIDINPSDLRIDVYRASGAGGQHVNTTES 259
Cdd:COG0216   164 FRISGEGVYSRLKFESGVHR-VQRVPeTESQGRIHTSAATVAVLPEAEE-VDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 260 AVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELELQQQNAEkQSQEdNKSDIGWG--SQ-IRSYVLDDSRIKDL 336
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAE-IAAE-RKSQVGSGdrSErIRTYNFPQGRVTDH 319

                         330       340
                  ....*....|....*....|...
gi 1243945372 337 RTGVENRNTQAVLDGDLDKFIEA 359
Cdd:COG0216   320 RINLTLYKLDEVMEGDLDELIDA 342
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 30-219 1.28e-74

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 229.19  E-value: 1.28e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  30 KQERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEAEDQDtfdEAQSELADLNQQ 109
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAE---LAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 110 LEGL--EFRRMFS--GSHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSG 185
Cdd:pfam03462  78 LEELeeELKLLLLpkDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1243945372 186 EYAYGWLRTETGVHRLVRKSPFDSSGRRHTSFAS 219
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFAT 191
PCRF smart00937
This domain is found in peptide chain release factors;
85-195 1.62e-45

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 151.85  E-value: 1.62e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372   85 ELAVEAEDQDTFDEAQSELADLN----QQLEGLEFRRMFSG-SHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAK 159
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEaeleEELEELLKLLLLPKdPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1243945372  160 GFKVELVEATDGDVAGIKGATVRFSGEYAYGWLRTE 195
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 3-365 0e+00

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 546.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372   3 EVNPVINQIKEIRERTELLRGYLDYALKQERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEG 82
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  83 LVELAVEAEDQDTFDEAQSELADLNQQLEGLEFRRMFSGSHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFK 162
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 163 VELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHRLVRKSPFDSSGRRHTSFASAFVYPEVDDNIEIDINPSDLRID 242
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRID 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 243 VYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELELQQQNAEKQSQEDNKSDIGWGSQ 322
Cdd:TIGR00020 241 TYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQ 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1243945372 323 IRSYVLDD-SRIKDLRTGVENRNTQAVLDGDLDKFIEASLKSGL 365
Cdd:TIGR00020 321 IRSYVLHPySMVKDLRTGYETGNVQAVLDGDIDQFIEAYLKWKL 364
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 63-365 4.50e-160

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 451.03  E-value: 4.50e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  63 LEAVVETIDTLVAGTDDVEGLVELAVEAEDQDTfdeAQSELADLNQ---QLEGLEFRRMFSGSHDSNDAYLDLQSGSGGT 139
Cdd:PRK08787    2 LEKTVIGIADVLSGLADAGELLDLAESEQDEDT---ALAVIADLDKyqaHVEKLEFQRMFSGQMDGANAFVDIQAGAGGT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 140 EAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHRLVRKSPFDSSGRRHTSFAS 219
Cdd:PRK08787   79 EAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 220 AFVYPEVDDNIEIDINPSDLRIDVYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELE 299
Cdd:PRK08787  159 VFVSPEVDDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELE 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1243945372 300 LQQQNAEKQSQEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVENRNTQAVLDGDLDKFIEASLKSGL 365
Cdd:PRK08787  239 VQKRNAEKDALEATKSDIGWGSQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEASLKAGL 304
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 42-361 2.14e-140

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 402.33  E-value: 2.14e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  42 EDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEAEDQDTFDEAQSELADLNQQLEGLEFRRMFSG 121
Cdd:PRK07342    4 EDPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSIVEDAEKTIRDLKDEIDRRQIDALLSG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 122 SHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHRL 201
Cdd:PRK07342   84 EADANDTYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 202 VRKSPFDSSGRRHTSFASAFVYPEVDDNIEIDINPSDLRIDVYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQH 281
Cdd:PRK07342  164 VRISPYDSNARRHTSFASIWVYPVIDDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQH 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 282 KNKAQAMKQLKAKLFELELQQQNAEKQSQEDNKSDIGWGSQIRSYVLDDSR-IKDLRTGVENRNTQAVLDGDLDKFIEAS 360
Cdd:PRK07342  244 KNRAKAWSMLRARLYEEELKKREEATNAAAASKTDIGWGHQIRSYVLQPYQlVKDLRTGVESTNPQDVLDGDLNEFMEAA 323


                  .
gi 1243945372 361 L 361
Cdd:PRK07342  324 L 324
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 41-363 1.92e-122

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 356.04  E-value: 1.92e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  41 LEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEaEDQDTFDEAQSELADLNQQLEGLEFRRMFS 120
Cdd:PRK05589    1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSE-EDDEMKKEIISEVKNIKEEIDRFKIETLLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 121 GSHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHR 200
Cdd:PRK05589   80 GEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 201 LVRKSPFDSSGRRHTSFASAFVYPEVDDNIEIDINPSDLRIDVYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQ 280
Cdd:PRK05589  160 LVRISPFNANGKRQTSFASVEVLPELTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 281 HKNKAQAMKQLKAKLFELelqQQNAEKQSQED---NKSDIGWGSQIRSYVLDD-SRIKDLRTGVENRNTQAVLDGDLDKF 356
Cdd:PRK05589  240 HSNKETAMKMLKSKLVEL---KERAHKEKIEDltgELKDMGWGSQIRSYVFHPyNLVKDHRTGVETSNVDSVMDGDIDNF 316


                  ....*..
gi 1243945372 357 IEASLKS 363
Cdd:PRK05589  317 ITQYLKG 323
prfA PRK00591
peptide chain release factor 1; Validated
 31-359 6.59e-113

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 332.81  E-value: 6.59e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  31 QERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEAEDQDTFDEAQSELADLNQQL 110
Cdd:PRK00591   12 EERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEELKELEERL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 111 EGLE--FRRMF--SGSHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSGE 186
Cdd:PRK00591   92 EELEeeLKILLlpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGD 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 187 YAYGWLRTETGVHRLVRKSPFDSSGRRHTSFASAFVYPEVDDnIEIDINPSDLRIDVYRASGAGGQHVNTTESAVRITHV 266
Cdd:PRK00591  172 GVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEE-VEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 267 PTNTVVQCQNERSQHKNKAQAMKQLKAKLFELELQQQNAEKQSqeDNKSDIGWGS---QIRSYVLDDSRIKDLRTGVENR 343
Cdd:PRK00591  251 PTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAA--TRKSQVGSGDrseRIRTYNFPQGRVTDHRINLTLY 328

                         330
                  ....*....|....*.
gi 1243945372 344 NTQAVLDGDLDKFIEA 359
Cdd:PRK00591  329 KLDEVMEGDLDELIDA 344
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 31-359 3.38e-108

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 320.79  E-value: 3.38e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  31 QERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEAEDQDTFDEAQSELADLNQQL 110
Cdd:COG0216    10 EERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELEARL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 111 EGLEFR-------RmfsgshDSND---AYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGAT 180
Cdd:COG0216    90 EELEEElkilllpK------DPNDdknVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 181 VRFSGEYAYGWLRTETGVHRlVRKSP-FDSSGRRHTSFASAFVYPEVDDnIEIDINPSDLRIDVYRASGAGGQHVNTTES 259
Cdd:COG0216   164 FRISGEGVYSRLKFESGVHR-VQRVPeTESQGRIHTSAATVAVLPEAEE-VDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 260 AVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELELQQQNAEkQSQEdNKSDIGWG--SQ-IRSYVLDDSRIKDL 336
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAE-IAAE-RKSQVGSGdrSErIRTYNFPQGRVTDH 319

                         330       340
                  ....*....|....*....|...
gi 1243945372 337 RTGVENRNTQAVLDGDLDKFIEA 359
Cdd:COG0216   320 RINLTLYKLDEVMEGDLDELIDA 342
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 44-363 4.15e-108

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 319.76  E-value: 4.15e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  44 SAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEAEDQDTFDEAQSELADLNQQLEGLEFRRMFSGSH 123
Cdd:PRK06746    4 AGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLSDPY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 124 DSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSGEYAYGWLRTETGVHRLVR 203
Cdd:PRK06746   84 DKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 204 KSPFDSSGRRHTSFASAFVYPEVDDNIEIDINPSDLRIDVYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKN 283
Cdd:PRK06746  164 ISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKN 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 284 KAQAMKQLKAKLFELELQQQNAEKQSQEDNKSDIGWGSQIRSYVLDD-SRIKDLRTGVENRNTQAVLDGDLDKFIEASLK 362
Cdd:PRK06746  244 REHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPySLVKDHRTNTEVGNVQAVMDGEIDPFIDAYLR 323


                  .
gi 1243945372 363 S 363
Cdd:PRK06746  324 S 324
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 30-219 1.28e-74

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 229.19  E-value: 1.28e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372  30 KQERLEEVNAELEDSAVWNEPERAQALGREKSALEAVVETIDTLVAGTDDVEGLVELAVEAEDQDtfdEAQSELADLNQQ 109
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAE---LAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 110 LEGL--EFRRMFS--GSHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAGIKGATVRFSG 185
Cdd:pfam03462  78 LEELeeELKLLLLpkDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1243945372 186 EYAYGWLRTETGVHRLVRKSPFDSSGRRHTSFAS 219
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFAT 191
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 228-337 2.74e-62

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 194.56  E-value: 2.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 228 DNIEIDINPSDLRIDVYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKNKAQAMKQLKAKLFELELQQQNAEK 307
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1243945372 308 QSQEDNKSDIGWGSQIRSYVLDD-SRIKDLR 337
Cdd:pfam00472  81 RRIKSQVGSGDRSEQIRTYNFKPqSRVKDHR 111
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 231-342 1.40e-51

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 168.39  E-value: 1.40e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 231 EIDINPSDLRIDVYRASGAGGQHVNTTESAVRITH------------VPTNTVVQCQNERSQHKNKAQAMKQLKAKLFEL 298
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1243945372 299 ELQQQNAEK-QSQEDNKSDIGWGSQIRsyvlddSRIKDLRTGVEN 342
Cdd:COG1186   100 ELEPKERRAtKPTRGSKKRRLWGKQIR------SMVKDLRGNVDD 138
PCRF smart00937
This domain is found in peptide chain release factors;
85-195 1.62e-45

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 151.85  E-value: 1.62e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372   85 ELAVEAEDQDTFDEAQSELADLN----QQLEGLEFRRMFSG-SHDSNDAYLDLQSGSGGTEAQDWCNILLRMYLRWGEAK 159
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEaeleEELEELLKLLLLPKdPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1243945372  160 GFKVELVEATDGDVAGIKGATVRFSGEYAYGWLRTE 195
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 129-326 1.24e-31

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 118.34  E-value: 1.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 129 YLDLQSGSGGTEAQDWCNILLRMYLRWGEAKGFKVELVEATDGDVAG-IKGATVRFSGEYAYGWLRTETGVHRLVRKSPF 207
Cdd:TIGR03072   2 LLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVPGtLRSALVSLDGEAAAALADRWEGTLLWICPSPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 208 DSSGRRHTSF--ASAFVYPEvddnieiDINPSDLRIDVYRASGAGGQHVNTTESAVRITHVPTNTVVQCQNERSQHKNKA 285
Cdd:TIGR03072  82 RPHHRRKNWFigVQRFSASE-------EATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKR 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1243945372 286 QAMKQLKAKLFELELQQQNAEKQSQEDNKSDIGWGSQIRSY 326
Cdd:TIGR03072 155 LATLLLAVRLADLQQEQAAALRAERRTAHHQIERGNPVRVF 195
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
225-293 3.09e-08

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 52.08  E-value: 3.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243945372 225 EVDDNIEIDinPSDLRIDVYRASGAGGQHVNTTESAV------RITHVPTNT------------------VVQCQNERSQ 280
Cdd:PRK09256    3 RITRRLVIP--ENELEWRFIRASGPGGQNVNKVSTAVelrfdiAASSLPEFYkerllalaghritkdgviVIKAQEFRSQ 80

                          90
                  ....*....|...
gi 1243945372 281 HKNKAQAMKQLKA 293
Cdd:PRK09256   81 ERNREDALERLVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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