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Conserved domains on  [gi|1245846982|ref|WP_096142402|]
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chemotaxis protein CheW [Shewanella algae]

Protein Classification

chemotaxis protein CheW( domain architecture ID 10002856)

chemotaxis protein CheW couples methyl-accepting chemoreceptors to the histidine kinase CheA and is essential for chemotaxis

Gene Ontology:  GO:0007165|GO:0006935
PubMed:  10049806|12011495
SCOP:  4001969

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CheW COG0835
Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];
10-163 6.85e-49

Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];


:

Pssm-ID: 440597  Cd Length: 151  Bit Score: 155.42  E-value: 6.85e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  10 AAAKDQSQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVI 89
Cdd:COG0835     1 LEAGANELQYLTFRLGGERYAIPIEKVREILPLPPITPVPGAPPWVLGVINLRGRVVPVIDLRALLGLPPTEDTERTRII 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1245846982  90 VLKVrldkQHKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDMRFIHGLTCVADKMVILLNINMLLGNEVLPDA 163
Cdd:COG0835    81 VLEV----GGRVVGLLVDSVSGVVRIDPDDIEPPPELLSGGLAPFITGVAKLDDRLILLLDLEKLLAEEELAAL 150
 
Name Accession Description Interval E-value
CheW COG0835
Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];
10-163 6.85e-49

Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];


Pssm-ID: 440597  Cd Length: 151  Bit Score: 155.42  E-value: 6.85e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  10 AAAKDQSQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVI 89
Cdd:COG0835     1 LEAGANELQYLTFRLGGERYAIPIEKVREILPLPPITPVPGAPPWVLGVINLRGRVVPVIDLRALLGLPPTEDTERTRII 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1245846982  90 VLKVrldkQHKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDMRFIHGLTCVADKMVILLNINMLLGNEVLPDA 163
Cdd:COG0835    81 VLEV----GGRVVGLLVDSVSGVVRIDPDDIEPPPELLSGGLAPFITGVAKLDDRLILLLDLEKLLAEEELAAL 150
CheW cd00732
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. ...
16-158 2.23e-47

CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.


Pssm-ID: 238374  Cd Length: 140  Bit Score: 151.18  E-value: 2.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  16 SQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLKVrl 95
Cdd:cd00732     1 ELEVVTFRLGDEEYGIPIMQVREILKPTPITPIPNAPPYVLGVINLRGRIVPVIDLRKRLGLPPAEDTKNTRIIVVEV-- 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1245846982  96 dkQHKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDMRFIHGLTCVADKMVILLNINMLLGNE 158
Cdd:cd00732    79 --GDQVVGLLVDSVSEVLRLSTDDIQPPPPVLSDINAKFIRGVVKLEGRLLILLDLDKILDER 139
PRK10612 PRK10612
chemotaxis protein CheW;
1-158 3.57e-45

chemotaxis protein CheW;


Pssm-ID: 182587  Cd Length: 167  Bit Score: 146.49  E-value: 3.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982   1 MTESNPATSAAAKDQSQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTL 80
Cdd:PRK10612    1 MTGMANVTKLAGEPSGQEFLVFTLGDEEYGIDILKVQEIRGYDQVTRIANTPAFIKGVTNLRGVIVPIVDLRIKFSQVDV 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1245846982  81 AYGPTTVVIVLKVrldkQHKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDMRFIHGLTCVADKMVILLNINMLLGNE 158
Cdd:PRK10612   81 DYNDNTVVIVLNL----GQRVVGIVVDGVSDVLSLTAEQIRPAPEFAVTLSTEYLTGLGALGERMLILVNIEKLLNSE 154
CheW pfam01584
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. ...
19-154 1.96e-36

CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.


Pssm-ID: 460257 [Multi-domain]  Cd Length: 131  Bit Score: 123.08  E-value: 1.96e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  19 YLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLKVrldkQ 98
Cdd:pfam01584   1 GLLFRLGGETFAIPISKVREILRPPPITPIPGAPGYVLGVINLRGEVLPVIDLRRLLGLPPTEPRERTRVVVVEV----G 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1245846982  99 HKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDmrFIHGLTCVAD-KMVILLNINML 154
Cdd:pfam01584  77 GQVVGLLVDEVIGVLEIVIKQIEPPLGLGRVAG--YISGATILGDgRVVLILDVEAL 131
CheW smart00260
Two component signalling adaptor domain;
17-155 1.07e-31

Two component signalling adaptor domain;


Pssm-ID: 214588 [Multi-domain]  Cd Length: 138  Bit Score: 111.18  E-value: 1.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982   17 QQYLTFMMA-DEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLKVrl 95
Cdd:smart00260   3 RLPLTFAIGkDETYAIPIAAVREILRPPPITPIPGAPGYVLGVINLRGEVLPVVDLRRLLGLPPEPPTDETRVIVVET-- 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1245846982   96 dkQHKVMGIVVDAVSDVFSITQSEIRSAPDfGQDTDMRFIHGLTCVAD-KMVILLNINMLL 155
Cdd:smart00260  81 --GDRKVGLVVDSVLGVREVVVKSIEPPPP-VSLSNAPGISGATILGDgRVVLILDVDKLL 138
 
Name Accession Description Interval E-value
CheW COG0835
Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];
10-163 6.85e-49

Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];


Pssm-ID: 440597  Cd Length: 151  Bit Score: 155.42  E-value: 6.85e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  10 AAAKDQSQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVI 89
Cdd:COG0835     1 LEAGANELQYLTFRLGGERYAIPIEKVREILPLPPITPVPGAPPWVLGVINLRGRVVPVIDLRALLGLPPTEDTERTRII 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1245846982  90 VLKVrldkQHKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDMRFIHGLTCVADKMVILLNINMLLGNEVLPDA 163
Cdd:COG0835    81 VLEV----GGRVVGLLVDSVSGVVRIDPDDIEPPPELLSGGLAPFITGVAKLDDRLILLLDLEKLLAEEELAAL 150
CheW cd00732
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. ...
16-158 2.23e-47

CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.


Pssm-ID: 238374  Cd Length: 140  Bit Score: 151.18  E-value: 2.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  16 SQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLKVrl 95
Cdd:cd00732     1 ELEVVTFRLGDEEYGIPIMQVREILKPTPITPIPNAPPYVLGVINLRGRIVPVIDLRKRLGLPPAEDTKNTRIIVVEV-- 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1245846982  96 dkQHKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDMRFIHGLTCVADKMVILLNINMLLGNE 158
Cdd:cd00732    79 --GDQVVGLLVDSVSEVLRLSTDDIQPPPPVLSDINAKFIRGVVKLEGRLLILLDLDKILDER 139
PRK10612 PRK10612
chemotaxis protein CheW;
1-158 3.57e-45

chemotaxis protein CheW;


Pssm-ID: 182587  Cd Length: 167  Bit Score: 146.49  E-value: 3.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982   1 MTESNPATSAAAKDQSQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTL 80
Cdd:PRK10612    1 MTGMANVTKLAGEPSGQEFLVFTLGDEEYGIDILKVQEIRGYDQVTRIANTPAFIKGVTNLRGVIVPIVDLRIKFSQVDV 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1245846982  81 AYGPTTVVIVLKVrldkQHKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDMRFIHGLTCVADKMVILLNINMLLGNE 158
Cdd:PRK10612   81 DYNDNTVVIVLNL----GQRVVGIVVDGVSDVLSLTAEQIRPAPEFAVTLSTEYLTGLGALGERMLILVNIEKLLNSE 154
CheW pfam01584
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. ...
19-154 1.96e-36

CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.


Pssm-ID: 460257 [Multi-domain]  Cd Length: 131  Bit Score: 123.08  E-value: 1.96e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  19 YLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLKVrldkQ 98
Cdd:pfam01584   1 GLLFRLGGETFAIPISKVREILRPPPITPIPGAPGYVLGVINLRGEVLPVIDLRRLLGLPPTEPRERTRVVVVEV----G 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1245846982  99 HKVMGIVVDAVSDVFSITQSEIRSAPDFGQDTDmrFIHGLTCVAD-KMVILLNINML 154
Cdd:pfam01584  77 GQVVGLLVDEVIGVLEIVIKQIEPPLGLGRVAG--YISGATILGDgRVVLILDVEAL 131
CheW smart00260
Two component signalling adaptor domain;
17-155 1.07e-31

Two component signalling adaptor domain;


Pssm-ID: 214588 [Multi-domain]  Cd Length: 138  Bit Score: 111.18  E-value: 1.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982   17 QQYLTFMMA-DEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLKVrl 95
Cdd:smart00260   3 RLPLTFAIGkDETYAIPIAAVREILRPPPITPIPGAPGYVLGVINLRGEVLPVVDLRRLLGLPPEPPTDETRVIVVET-- 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1245846982   96 dkQHKVMGIVVDAVSDVFSITQSEIRSAPDfGQDTDMRFIHGLTCVAD-KMVILLNINMLL 155
Cdd:smart00260  81 --GDRKVGLVVDSVLGVREVVVKSIEPPPP-VSLSNAPGISGATILGDgRVVLILDVDKLL 138
CheW_like cd00588
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. ...
16-152 7.38e-30

CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in the chemotaxis associated histidine kinase CheA binds to CheW, suggesting that these domains can interact with each other.


Pssm-ID: 238331  Cd Length: 136  Bit Score: 106.59  E-value: 7.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  16 SQQYLTFMMADEEYGVDILSVQEIRGWEATTVIPNAPPHVKGVINLRGTIVPIIDLRQRFGIK-TLAYGPTTVVIVLKVR 94
Cdd:cd00588     1 ILQVLLFRVGDELYAIPIAVVEEILPLPPITRVPNAPDYVLGVINLRGEILPVIDLRRLFGLEaAEPDTDETRIVVVEVG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1245846982  95 ldkqHKVMGIVVDAVSDVFSITQSEIRSAPDfGQDTDMRFIHGLTCV-ADKMVILLNIN 152
Cdd:cd00588    81 ----DRKVGLVVDSVLGVLEVVIKDIEPPPD-VGSSNAPGISGATILgDGRVVLILDVD 134
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
20-109 6.57e-06

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 45.56  E-value: 6.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  20 LTFMMADEEYGVDILSVQEIRGWEATTVipnAPPHVKGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLkvrLDKQH 99
Cdd:COG0643   426 LLVRVGGETYAIPLSSVEEVLRLDPDDI---ETVEGREVIRLRGELLPLVRLGELLGLPGAEPEGERGPVVV---VRSGG 499
                          90
                  ....*....|
gi 1245846982 100 KVMGIVVDAV 109
Cdd:COG0643   500 RRVALVVDEL 509
CheA_reg cd00731
CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. ...
23-109 1.14e-04

CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling mechanism is modulated by the methyl accepting chemotaxis proteins (MCPs). MCPs form a highly interconnected, tightly packed array within the membrane that is organized, at least in part, through interactions with CheW and CheA. The CheA regulatory domain belongs to the family of CheW_like proteins and has been proposed to mediate interaction with the kinase regulator CheW.


Pssm-ID: 238373 [Multi-domain]  Cd Length: 132  Bit Score: 40.24  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245846982  23 MMADEEYGVDILSVQEIRgweattVIPNAPPHV----KGVINLRGTIVPIIDLRQRFGIKTLAYGPTTVVIVLkVRLDKQ 98
Cdd:cd00731    10 RVGDETYAIPLSAVVETV------RIKPKDIKRvdggKEVINVRGELLPLVRLGELFNVRGENEEPDEGVVVV-VRTGGR 82
                          90
                  ....*....|.
gi 1245846982  99 HkvMGIVVDAV 109
Cdd:cd00731    83 K--AALVVDQI 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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