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Conserved domains on  [gi|1246904165|ref|WP_096488106|]
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MULTISPECIES: Rrf2 family transcriptional regulator [Hyphomicrobiales]

Protein Classification

Rrf2 family transcriptional regulator( domain architecture ID 10489162)

Rrf2 family transcriptional regulator similar to nitric oxide-responsive regulator NsrR

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 10-140 3.73e-27

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 98.78  E-value: 3.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  10 VDQRFAVAVHAMCVLSYHSP-ELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHA 88
Cdd:pfam02082   1 LSTKTDYALHALLYLALHPGgEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVRGAGGGYRLARPPEEITLLDVVRA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246904165  89 VQGNGPFRSRygmPESNCDEGRAIDRVVFDLYEDLDQEIERRLSQITLAQIL 140
Cdd:pfam02082  81 VEGPLALFEC---NNPKCPCGIEIQCALREAWEEAQDAMEDVLDSVTLADLV 129
 
Name Accession Description Interval E-value
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 10-140 3.73e-27

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 98.78  E-value: 3.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  10 VDQRFAVAVHAMCVLSYHSP-ELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHA 88
Cdd:pfam02082   1 LSTKTDYALHALLYLALHPGgEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVRGAGGGYRLARPPEEITLLDVVRA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246904165  89 VQGNGPFRSRygmPESNCDEGRAIDRVVFDLYEDLDQEIERRLSQITLAQIL 140
Cdd:pfam02082  81 VEGPLALFEC---NNPKCPCGIEIQCALREAWEEAQDAMEDVLDSVTLADLV 129
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
10-140 1.63e-23

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 89.51  E-value: 1.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  10 VDQRFAVAVHAMCVLSYHSP-ELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHA 88
Cdd:COG1959     2 LSTKTDYALRALLYLALHPGgEPVTSKEIAERQGISPSYLEKILQKLRKAGLVESVRGPGGGYRLARPPEEITLGDVVRA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246904165  89 VQGNGPFrSRYGMPESNCDEGRAidRVVFDLYEDLDQEIERRLSQITLAQIL 140
Cdd:COG1959    82 VEGPLAL-VECVSGPPDCPVEEA--CALHGVWEEAEDAILEVLDSVTLADLV 130
rrf2_super TIGR00738
Rrf2 family protein; This model represents a superfamily of probable transcriptional ...
 17-140 6.20e-20

Rrf2 family protein; This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General]


Pssm-ID: 273242  Cd Length: 132  Bit Score: 80.37  E-value: 6.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  17 AVHAMCVLSYHSPE-LSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHAVqgNGPF 95
Cdd:TIGR00738  10 ALRALLDLALNPDEgPVSVKEIAERQGISRSYLEKILRTLRKAGLVESVRGPGGGYRLARPPEEITVGDVVRAV--EGSL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1246904165  96 RSRYGMPESNCDEGRAiDRVVFDLYEDLDQEIERRLSQITLAQIL 140
Cdd:TIGR00738  88 APVQCIGLNGCHPGEE-VCLLHAVWRELEDAIEDFLREITLADLV 131
rirA PRK11920
iron-responsive transcriptional regulator RirA;
19-92 2.74e-06

iron-responsive transcriptional regulator RirA;


Pssm-ID: 171344  Cd Length: 153  Bit Score: 44.77  E-value: 2.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246904165  19 HAMCVLSY---HSPELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHAVQGN 92
Cdd:PRK11920    9 YAIRMLMYcaaNDGKLSRIPEIARAYGVSELFLFKILQPLVEAGLVETVRGRNGGVRLGRPAADISLFDVVRVTEDS 85
 
Name Accession Description Interval E-value
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 10-140 3.73e-27

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 98.78  E-value: 3.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  10 VDQRFAVAVHAMCVLSYHSP-ELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHA 88
Cdd:pfam02082   1 LSTKTDYALHALLYLALHPGgEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVRGAGGGYRLARPPEEITLLDVVRA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246904165  89 VQGNGPFRSRygmPESNCDEGRAIDRVVFDLYEDLDQEIERRLSQITLAQIL 140
Cdd:pfam02082  81 VEGPLALFEC---NNPKCPCGIEIQCALREAWEEAQDAMEDVLDSVTLADLV 129
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
10-140 1.63e-23

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 89.51  E-value: 1.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  10 VDQRFAVAVHAMCVLSYHSP-ELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHA 88
Cdd:COG1959     2 LSTKTDYALRALLYLALHPGgEPVTSKEIAERQGISPSYLEKILQKLRKAGLVESVRGPGGGYRLARPPEEITLGDVVRA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246904165  89 VQGNGPFrSRYGMPESNCDEGRAidRVVFDLYEDLDQEIERRLSQITLAQIL 140
Cdd:COG1959    82 VEGPLAL-VECVSGPPDCPVEEA--CALHGVWEEAEDAILEVLDSVTLADLV 130
rrf2_super TIGR00738
Rrf2 family protein; This model represents a superfamily of probable transcriptional ...
 17-140 6.20e-20

Rrf2 family protein; This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General]


Pssm-ID: 273242  Cd Length: 132  Bit Score: 80.37  E-value: 6.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  17 AVHAMCVLSYHSPE-LSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHAVqgNGPF 95
Cdd:TIGR00738  10 ALRALLDLALNPDEgPVSVKEIAERQGISRSYLEKILRTLRKAGLVESVRGPGGGYRLARPPEEITVGDVVRAV--EGSL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1246904165  96 RSRYGMPESNCDEGRAiDRVVFDLYEDLDQEIERRLSQITLAQIL 140
Cdd:TIGR00738  88 APVQCIGLNGCHPGEE-VCLLHAVWRELEDAIEDFLREITLADLV 131
rirA PRK11920
iron-responsive transcriptional regulator RirA;
19-92 2.74e-06

iron-responsive transcriptional regulator RirA;


Pssm-ID: 171344  Cd Length: 153  Bit Score: 44.77  E-value: 2.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246904165  19 HAMCVLSY---HSPELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHAVQGN 92
Cdd:PRK11920    9 YAIRMLMYcaaNDGKLSRIPEIARAYGVSELFLFKILQPLVEAGLVETVRGRNGGVRLGRPAADISLFDVVRVTEDS 85
suf_reg_Xantho TIGR02944
FeS assembly SUF system regulator, gammaproteobacterial; The SUF system is an oxygen-resistant ...
 17-139 1.92e-05

FeS assembly SUF system regulator, gammaproteobacterial; The SUF system is an oxygen-resistant iron-sulfur cluster assembly system found in both aerobes and facultative anaerobes. Its presence appears to be a marker of oxygen tolerance; strict anaerobes and microaerophiles tend to have different FeS cluster biosynthesis systems. Members of this protein family belong to the rrf2 family of transcriptional regulators and are found, typically, as the first gene of a SUF operon. It is found only in a subset of genomes that encode the SUF system, including the genus Xanthomonas. The conserved location suggests an autoregulatory role. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Regulatory functions, DNA interactions]


Pssm-ID: 131989 [Multi-domain]  Cd Length: 130  Bit Score: 42.10  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246904165  17 AVHAMCVLSYHSPELSNASFVGDSISVNPLIAKRIIGSMVKAGLAEAVLGARGGYRLARSADQVSLWDIYHAVQGNgPFR 96
Cdd:TIGR02944  11 ATLVLTTLAQNDSQPYSAAEIAEQTGLNAPTVSKILKQLSLAGIVTSKRGVEGGYTLARAPRDITVADIVKAVEGP-VAL 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246904165  97 SRYGMPESNCDEG---------RAIDRVVFDLyedldqeierrLSQITLAQI 139
Cdd:TIGR02944  90 TECSDDQKKCSLGnscgvrsnwKVINSQVLDL-----------LSSVSLADM 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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