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Conserved domains on  [gi|1252952806|ref|WP_096863190|]
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MULTISPECIES: 3-isopropylmalate dehydrogenase [Providencia]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-361 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 712.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   3 SYKIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEH 82
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  83 LPPDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAAqGFDILCVRELTGGIYFGQPKGRKGEGQEEYAFD 162
Cdd:PRK00772   82 LPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 163 TEVYHRYEIERIARIAFESARKRNNKVTSIDKANVLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDVV 242
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 243 LCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIE 322
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1252952806 323 RAVNKALEEGYRTSDLAGAGQSISTSEMGDIIARYIAEG 361
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-361 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 712.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   3 SYKIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEH 82
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  83 LPPDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAAqGFDILCVRELTGGIYFGQPKGRKGEGQEEYAFD 162
Cdd:PRK00772   82 LPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 163 TEVYHRYEIERIARIAFESARKRNNKVTSIDKANVLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDVV 242
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 243 LCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIE 322
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1252952806 323 RAVNKALEEGYRTSDLAGAGQSISTSEMGDIIARYIAEG 361
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-354 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 605.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   5 KIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEHLP 84
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  85 PDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAaQGFDILCVRELTGGIYFGQPKGRKGEGqeeYAFDTE 164
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 165 VYHRYEIERIARIAFESARKRNNKVTSIDKANVLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDVVLC 244
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 245 SNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIERA 324
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1252952806 325 VNKALEEGYRTSDLAG-AGQSISTSEMGDII 354
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSsATTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-358 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 595.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   3 SYKIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWeh 82
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  83 lpPDSQPERGALLPLRKHFKLFSNLRPARLYQALEafCPLRADIAaQGFDILCVRELTGGIYFGQPKGRKGEGQEEYAFD 162
Cdd:COG0473    79 --DDGVRPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIV-EGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 163 TEVYHRYEIERIARIAFESARKRNNKVTSIDKANVL-QSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDV 241
Cdd:COG0473   154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 242 VLCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFsLDQADAADAI 321
Cdd:COG0473   234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1252952806 322 ERAVNKALEEGYRTSDLAGagqSISTSEMGDIIARYI 358
Cdd:COG0473   313 EAAVEKVLAEGVRTPDLGG---KAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-354 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 531.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   5 KIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEhlP 84
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  85 PDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAaqGFDILCVRELTGGIYFGQPKGRKGEGQEeYAFDTE 164
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGNE-VAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 165 VYHRYEIERIARIAFESARKRN-NKVTSIDKANVLQSSVLWREVVNQIAK-EYPDVEVSHMYIDNAAMQMIKAPSQFDVV 242
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 243 LCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIE 322
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1252952806 323 RAVNKALEEGYRTSDLAGAGQSISTSEMGDII 354
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-361 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 712.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   3 SYKIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEH 82
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  83 LPPDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAAqGFDILCVRELTGGIYFGQPKGRKGEGQEEYAFD 162
Cdd:PRK00772   82 LPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 163 TEVYHRYEIERIARIAFESARKRNNKVTSIDKANVLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDVV 242
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 243 LCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIE 322
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1252952806 323 RAVNKALEEGYRTSDLAGAGQSISTSEMGDIIARYIAEG 361
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-354 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 605.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   5 KIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEHLP 84
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  85 PDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAaQGFDILCVRELTGGIYFGQPKGRKGEGqeeYAFDTE 164
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 165 VYHRYEIERIARIAFESARKRNNKVTSIDKANVLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDVVLC 244
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 245 SNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIERA 324
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1252952806 325 VNKALEEGYRTSDLAG-AGQSISTSEMGDII 354
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSsATTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-358 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 595.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   3 SYKIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWeh 82
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  83 lpPDSQPERGALLPLRKHFKLFSNLRPARLYQALEafCPLRADIAaQGFDILCVRELTGGIYFGQPKGRKGEGQEEYAFD 162
Cdd:COG0473    79 --DDGVRPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIV-EGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 163 TEVYHRYEIERIARIAFESARKRNNKVTSIDKANVL-QSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDV 241
Cdd:COG0473   154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 242 VLCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFsLDQADAADAI 321
Cdd:COG0473   234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1252952806 322 ERAVNKALEEGYRTSDLAGagqSISTSEMGDIIARYI 358
Cdd:COG0473   313 EAAVEKVLAEGVRTPDLGG---KAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-354 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 531.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   5 KIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEhlP 84
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  85 PDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAaqGFDILCVRELTGGIYFGQPKGRKGEGQEeYAFDTE 164
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGNE-VAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 165 VYHRYEIERIARIAFESARKRN-NKVTSIDKANVLQSSVLWREVVNQIAK-EYPDVEVSHMYIDNAAMQMIKAPSQFDVV 242
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 243 LCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIE 322
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1252952806 323 RAVNKALEEGYRTSDLAGAGQSISTSEMGDII 354
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 4-362 6.60e-121

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 355.15  E-value: 6.60e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   4 YKIAVLPGDGIGPEVMAQAHKVLAAISKRFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKWEHL 83
Cdd:PLN02329   47 YNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKN 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  84 PPDSQPERGaLLPLRKHFKLFSNLRPARLYQALEAFCPLRADIAaQGFDILCVRELTGGIYFGQPKGRK-GEGQEEYAFD 162
Cdd:PLN02329  127 EKHLRPEMA-LFYLRRDLKVFANLRPATVLPQLVDASTLKKEVA-EGVDMMIVRELTGGIYFGEPRGITiNENGEEVGVS 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 163 TEVYHRYEIERIARIAFESARKRNNKVTSIDKANVLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQFDVV 242
Cdd:PLN02329  205 TEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTI 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 243 LCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFSLDQADAADAIE 322
Cdd:PLN02329  285 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIE 364

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1252952806 323 RAVNKALEEGYRTSDLAGAGQS-ISTSEMGDIIARYIAEGV 362
Cdd:PLN02329  365 DAVVDALNKGFRTGDIYSPGNKlVGCKEMGEEVLKSVDSKV 405
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 2-358 5.46e-102

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 304.54  E-value: 5.46e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   2 SSYKIAVLPGDGIGPEVMAQAHKVLAAISKRfAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKwe 81
Cdd:PRK03437    3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPS-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  82 hLPPDSQpERGALLPLRKHFKLFSNLRPARLYQALEafCPLRA--DIaaqgfDILCVRELTGGIYFGQpkG---RKGEGQ 156
Cdd:PRK03437   80 -VPSGVL-ERGLLLKLRFALDHYVNLRPSKLYPGVT--SPLAGpgDI-----DFVVVREGTEGPYTGN--GgalRVGTPH 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 157 EeYAFDTEVYHRYEIERIARIAFESARKRNNK-VTSIDKANVL-QSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIK 234
Cdd:PRK03437  149 E-VATEVSVNTAFGVERVVRDAFERAQKRPRKhLTLVHKTNVLtFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVT 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 235 APSQFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGFG--LYEPAGGSAPDIAGKNIANPIAQILSASMLLRFsL 312
Cdd:PRK03437  228 DPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH-L 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1252952806 313 DQADAADAIERAVNKALEEgyrtsdlaGAGQSISTSEMGDIIARYI 358
Cdd:PRK03437  307 GEEDAAARIEAAVEADLAE--------RGKMGRSTAEVGDRIAARL 344
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 1-355 1.04e-93

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 283.65  E-value: 1.04e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   1 MSSYKIAVLPGDGIGPEVMAQAHKVLAAISKRFA-ITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPK 79
Cdd:TIGR02089   1 MKQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  80 wehLPPDSQPERGALLPLRKHFKLFSNLRPARLYQALEAfcPLRADiAAQGFDILCVRELTGGIYFGQpKGRKGEG-QEE 158
Cdd:TIGR02089  81 ---LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTS--PLRNC-GPGDFDFVVVRENSEGEYSGV-GGRIHRGtDEE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 159 YAFDTEVYHRYEIERIARIAFESARKRNNKVTSIDKAN-VLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPS 237
Cdd:TIGR02089 154 VATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNgIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 238 QFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGF--GLYEPAGGSAPDIAGKNIANPIAQILSASMLLRfSLDQA 315
Cdd:TIGR02089 234 TFDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLE-HLGEK 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1252952806 316 DAADAIERAVNKALEEGYRTSDLAGAGqsiSTSEMGDIIA 355
Cdd:TIGR02089 313 EAGAKIMDAIERVTAAGILTPDVGGKA---TTSEVTEAVC 349
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 3-358 1.21e-88

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 270.08  E-value: 1.21e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   3 SYKIAVLPGDGIGPEVMAQAHKVLAAISKRFAITinttEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGgpkweH 82
Cdd:PRK14025    1 MHKICVIEGDGIGKEVVPAALHVLEATGLPFEFV----YAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG-----E 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  83 LPPDsqpergALLPLRKHFKLFSNLRPARLYQALEAFCPlradiaaqGFDILCVRELTGGIYfgqpKGRKGEGQEEYAFD 162
Cdd:PRK14025   72 TAAD------VIVKLRRILDTYANVRPVKSYKGVKCLYP--------DIDYVIVRENTEGLY----KGIEAEIADGVTVA 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 163 TEVYHRYEIERIARIAFESARKR-----NNKVTSIDKANVLQSSV-LWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAP 236
Cdd:PRK14025  134 TRVITRKASERIFRFAFEMAKRRkkmgkEGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRP 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 237 SQFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEvGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFsLDQAD 316
Cdd:PRK14025  214 QTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGD-KYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENE 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1252952806 317 AADAIERAVNKALEEGYRTSDLAGagqSISTSEMGDIIARYI 358
Cdd:PRK14025  292 EADKVEKALEEVLALGLTTPDLGG---NLSTMEMAEEVAKRV 330
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 1-356 5.07e-87

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 266.59  E-value: 5.07e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   1 MSSYKIAVLPGDGIGPEVMAQAHKVLAAISK-RFAITINTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPK 79
Cdd:PRK08194    1 MKQFKIAVIPGDGVGKEVVPAAVRVLKAVAEvHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  80 wehLPPDSQPERGALLPLRKHFKLFSNLRPARLYQALEAfcPLRAdiaAQGFDILCVRELTGGIYfGQPKGRKGEGQEEY 159
Cdd:PRK08194   81 ---LVPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKS--PLAN---PKDFDLLVVRENSEGEY-SEVGGRIHRGEDEI 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 160 AFDTEVYHRYEIERIARIAFESARKRNNKVTSIDKAN-VLQSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQ 238
Cdd:PRK08194  152 AIQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 239 FDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGF--GLYEPAGGSAPDIAGKNIANPIAQILSASMLLRfSLDQAD 316
Cdd:PRK08194  232 FDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLD-HFGEEE 310

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1252952806 317 AADAIERAVNKALEEGYRTSDLAGAGqsiSTSEMGD-IIAR 356
Cdd:PRK08194  311 LGSHLLDVIEDVTEDGIKTPDIGGRA---TTDEVTDeIISR 348
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 2-358 8.11e-80

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 247.32  E-value: 8.11e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   2 SSYKIAVLPGDGIGPEVMAQAHKVLAAISKRFaitinTTEY-DVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGPKW 80
Cdd:PRK08997    1 MKQTITVIPGDGIGPSIIDATLKILDKLGCDF-----EYEFaDAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  81 EHLPPDSqpergalLPLRKHFKLFSNLRPARLYQALEAfcplRADiaaqGFDILCVRELTGGIYFGQPKGRKGEGQEeyA 160
Cdd:PRK08997   76 EGFTSIN-------VTLRKKFDLYANVRPVLSFPGTKA----RYD----NIDIITVRENTEGMYSGEGQTVSEDGET--A 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 161 FDTEVYHRYEIERIARIAFESARKRN-NKVTSIDKANVLQS-SVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQ 238
Cdd:PRK08997  139 EATSIITRKGAERIVRFAYELARKEGrKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQ 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 239 FDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGfGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFsLDQADAA 318
Cdd:PRK08997  219 FDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKA 296

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1252952806 319 DAIERAVNKALEEGYRTS-DLAGAGqsiSTSEMGDIIARYI 358
Cdd:PRK08997  297 ERIRKAIVAVIEAGDRTTrDLGGTH---GTTDFTQAVIDRL 334
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-356 1.57e-61

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 204.74  E-value: 1.57e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   1 MSSYKIAVLPGDGIGPEVMAQAHKVLAAISKRfaITINTTEYdvgGAAIDKHGEP--LPQATVKGCEEADAVLFGSVGGP 78
Cdd:PRK09222    2 AEKTPITVAYGDGIGPEIMEAVLKILEAAGAP--LEIETIEI---GEKVYKKGWTsgISPSAWESIRRTKVLLKAPITTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  79 KwehlppdSQPERGALLPLRKHFKLFSNLRPARLYqalEAFCPLRADiaaqGFDILCVRE----LTGGIyfgqpkgrkge 154
Cdd:PRK09222   77 Q-------GGGYKSLNVTLRKTLGLYANVRPCVSY---HPFVETKHP----NLDVVIIREneedLYAGI----------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 155 gqeEYAFDTEVYHRYEI------ERIARIAFESARKRN-NKVTSIDKANVL-QSSVLWREVVNQIAKEYPDVEVSHMYID 226
Cdd:PRK09222  132 ---EHRQTPDVYQCLKLisrpgsEKIIRYAFEYARANGrKKVTCLTKDNIMkLTDGLFHKVFDEIAKEYPDIEAEHYIVD 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 227 NAAMQMIKAPSQFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEvGFGLYEPAGGSAPDIAGKNIANPIAQILSASM 306
Cdd:PRK09222  209 IGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGE-EYAMFEAVHGSAPDIAGKNIANPSGLLNAAVM 287

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1252952806 307 LLRFsLDQADAADAIERAVNKALEEGYRTSDLAGAGQS---ISTSEMGD-IIAR 356
Cdd:PRK09222  288 MLVH-IGQFDIAELIENAWLKTLEDGIHTADIYNEGVSkkkVGTKEFAEaVIEN 340
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 2-349 3.06e-51

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 174.68  E-value: 3.06e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   2 SSYKIAVLPGDGIGPEVMAQAHKVLAAISkrfaITINTTEYDVGgaaidKHGEPLPQATVKgCEEADAVLFGSVG--GPK 79
Cdd:PLN00118   40 TPITATLFPGDGIGPEIAESVKQVFTAAG----VPIEWEEHYVG-----TTVDPRTGSFLT-WESLESVRRNKVGlkGPM 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  80 wehLPPDSQPERGALLPLRKHFKLFSNLRPARLYQALEAfcplRADiaaqGFDILCVRELTGGIYfgqpKGRKGEGQEEY 159
Cdd:PLN00118  110 ---ATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKT----RYD----DVDLVTIRENTEGEY----SGLEHQVVRGV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 160 AFDTEVYHRYEIERIARIAFESARKRNNK-VTSIDKANVLQSSV-LWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPS 237
Cdd:PLN00118  175 VESLKIITRQASLRVAEYAFHYAKTHGRKrVSAIHKANIMKKTDgLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPA 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 238 QFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRfSLDQADA 317
Cdd:PLN00118  255 LFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLR-HLKLNEQ 333

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1252952806 318 ADAIERAVNKALEEG-YRTSDLAGagqSISTSE 349
Cdd:PLN00118  334 AEQIHNAILNTIAEGkYRTADLGG---SSTTTD 363
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
11-352 4.34e-38

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 140.74  E-value: 4.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  11 GDGIGPEVMAQAHKVL-AAISKRFAIT--INTTEYDVGGAAIDKHGEPLPQATVKGCEEADAVLFGSVGGP---KWehlp 84
Cdd:PRK06451   31 GDGIGPEITHAAMKVInKAVEKAYGSDreIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkGW---- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  85 pdsqpeRGALLPLRKHFKLFSNLRPARLYQALEAfcPLRAdiaAQGFDILCVRELTGGIYFG--------QPKGRKGEGQ 156
Cdd:PRK06451  107 ------KSINVAIRLMLDLYANIRPVKYIPGIES--PLKN---PEKIDLIIFRENTDDLYRGieypydseEAKKIRDFLR 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 157 EEYAFDTE--------VYHRYEIERIARIAFESARKRN-NKVTSIDKANVLQ-SSVLWREVVNQIA-KEYPDV-----EV 220
Cdd:PRK06451  176 KELGVEVEddtgigikLISKFKTQRIARMAIKYAIDHKrKKVTIMHKGNVMKyTEGAFREWAYEVAlKEFRDYvvteeEV 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 221 SHMYI---------------DNAAMQMIKAPSQFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGfGLYEPAGGS 285
Cdd:PRK06451  256 TKNYNgvppsgkviindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMFEAIHGT 334

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1252952806 286 APDIAGKNIANPIAQILSASMLLRFsLDQADAADAIERAVNKALEEGYRTSDLAG--AGQSISTSEMGD 352
Cdd:PRK06451  335 APKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfmGVRALSTTEYTD 402
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 6-356 8.64e-35

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 130.75  E-value: 8.64e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   6 IAVLPGDGIGPEVMAQAHKVLAAISKrfaiTINTTEYDVGGAAidkhgEPLPQATVKGCEEADAVLFGSVggpkwehlpp 85
Cdd:PLN00123   33 VTLIPGDGIGPLVTGAVEQVMEAMHA----PVYFERYEVHGDM-----KKVPEEVLESIRRNKVCLKGGL---------- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  86 dSQPERGAL----LPLRKHFKLFSNLRPARLYQALeafcPLRADiaaqGFDILCVRELTGGIYfgqpKGRKGEGQEEYAF 161
Cdd:PLN00123   94 -ATPVGGGVsslnVQLRKELDLFASLVNCFNLPGL----PTRHE----NVDIVVIRENTEGEY----SGLEHEVVPGVVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 162 DTEVYHRYEIERIARIAFESARKRNNK-VTSIDKANVL-QSSVLWREVVNQIAKEYPDVEVSHMYIDNAAMQMIKAPSQF 239
Cdd:PLN00123  161 SLKVITKFCSERIAKYAFEYAYLNNRKkVTAVHKANIMkLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 240 DVVLCSNLFGDIISDECAMITGSMGMLPSASLNEvGFGLYEpAGGSAPDIAGKNI-----ANPIAQILSASMLLRfSLDQ 314
Cdd:PLN00123  241 DVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGA-DHAVFE-QGASAGNVGNEKLveqkkANPVALLLSSAMMLR-HLQF 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1252952806 315 ADAADAIERAVNKALEEG-YRTSDLAGAGqsiSTSEMGDIIAR 356
Cdd:PLN00123  318 PSFADRLETAVKRVIAEGkYRTKDLGGSS---TTQEVVDAVIA 357
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 6-354 5.89e-23

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 98.98  E-value: 5.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806   6 IAVLPGDGIGPEVMAQAHKVL-AAISKRFA--ITINTTEYDVGGAAIDKHGEP--LPQATVKGCEEADAVLFGsvggpkw 80
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVdAAVEKAYKgeRKISWMEIYAGEKATKVYGEDvwLPEETLDLIREYRVAIKG------- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806  81 ehlpPDSQPERGAL----LPLRKHFKLFSNLRPARLYQALEAfcPLRAdiaAQGFDILCVRELTGGIYFG-QPKGRKGEG 155
Cdd:PRK07006   95 ----PLTTPVGGGIrslnVALRQELDLYVCLRPVRYFKGVPS--PVKR---PEDTDMVIFRENSEDIYAGiEWKAGSAEA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 156 QEEYAFDTEVYHRYEI------------------ERIARIAFESARKRNNK-VTSIDKANVLQ-SSVLWREVVNQIA-KE 214
Cdd:PRK07006  166 KKVIKFLQEEMGVKKIrfpetsgigikpvseegtERLVRAAIEYAIDNDRKsVTLVHKGNIMKfTEGAFKDWGYQLAeEE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 215 YPDvEV----SHMYIDNAA----------------MQMIKAPSQFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEv 274
Cdd:PRK07006  246 FGD-ELidggPWDKIKNPEtgkeiivkdsiadaflQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIND- 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 275 GFGLYEPAGGSAPDIAGKNIANPIAQILSASMLLRFsLDQADAADAIERAVNKALEEGYRTSDLA----GAGQsISTSEM 350
Cdd:PRK07006  324 GHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFArlmeGATE-VKCSEF 401


                  ....
gi 1252952806 351 GDII 354
Cdd:PRK07006  402 GDAL 405
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
225-339 3.92e-12

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 67.05  E-value: 3.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 225 IDNAAMQMIKA-PSQFDVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGfGLYEPAGGSAPDIAGKNIANPIAQILS 303
Cdd:PRK07362  338 IADSIFQQIQTrPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILS 416

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1252952806 304 ASMLLRFsLDQADAADAIERAVNKALEEGYRTSDLA 339
Cdd:PRK07362  417 GVMMLEY-LGWQEAADLITKGLSAAIANKQVTYDLA 451
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
222-349 1.11e-05

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 46.77  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252952806 222 HMYIDNAAMQMIKAPSQFdVVLCSNLFGDIISDECAMITGSMGMLPSASLNEVGFGL-YEPAGGSAPD-----IAGKNIA 295
Cdd:PRK08299  246 HRLIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVeAEAAHGTVTRhyrqhQKGEETS 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1252952806 296 -NPIAQILSASMLLRF--SLDQ----ADAADAIERAVNKALEEGYRTSDLA---GAGQSISTSE 349
Cdd:PRK08299  325 tNPIASIFAWTRGLAHrgKLDGnpelVKFADTLEKVCIETVESGFMTKDLAllvGPDQKWLTTE 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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