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Conserved domains on  [gi|1253007271|ref|WP_096902549|]
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MULTISPECIES: AraC family transcriptional regulator [Acinetobacter]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11454391)

helix-turn-helix (HTH) domain-containing protein with an AraC family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.60
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  10473770|15808743|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
91-338 1.88e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 1.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271  91 YAIMTAHEISDALILANRFIQLRMPFLQLFFSTFGEKASLQLQCDIHMEPLRTEIAIALIIGMITMSKAMTGTEHFTGEV 170
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 171 DFDFPKPAGFDQYFAKFPYHQFRFDQPYLGLSFDKQYLGLKMINADPIASQIAINQCEAELSALGERRRISMRVRDILTH 250
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 251 AEQhyLSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWS 329
Cdd:COG2207   166 LLL--LTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRF 243


                  ....*....
gi 1253007271 330 GRSPSNWRK 338
Cdd:COG2207   244 GVTPSEYRK 252
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
91-338 1.88e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 1.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271  91 YAIMTAHEISDALILANRFIQLRMPFLQLFFSTFGEKASLQLQCDIHMEPLRTEIAIALIIGMITMSKAMTGTEHFTGEV 170
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 171 DFDFPKPAGFDQYFAKFPYHQFRFDQPYLGLSFDKQYLGLKMINADPIASQIAINQCEAELSALGERRRISMRVRDILTH 250
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 251 AEQhyLSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWS 329
Cdd:COG2207   166 LLL--LTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRF 243


                  ....*....
gi 1253007271 330 GRSPSNWRK 338
Cdd:COG2207   244 GVTPSEYRK 252
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
256-337 4.31e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 93.77  E-value: 4.31e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271  256 LSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWSGRSPS 334
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 1253007271  335 NWR 337
Cdd:smart00342  82 EYR 84
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 28-212 1.80e-21

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 90.01  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271  28 GYNADTLFAPFQLNSEMLADPECRIPTPIANELVKHALKLTGESTLGYHLGTQMRISIHGFIGYAIMTAHEISDALILAN 107
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 108 RFIQLRMPFLQL-FFSTFGEKASLQLQCDIHMEPLRTEIAIALIIGMITMSKAMTGTEHFTGEVDFDFPKPAGFDQYFAK 186
Cdd:pfam12625  81 RYLRLLSDALELrLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*.
gi 1253007271 187 FPYHqFRFDQPYLGLSFDKQYLGLKM 212
Cdd:pfam12625 161 FGCP-VRFGAPRNALVFDAADLDRPL 185
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 243-338 4.31e-12

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 65.79  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 243 RVRDILTHAEQHYLSIENVADYLHMSDRTLKRQLAAEGTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFS 322
Cdd:PRK15185  210 RVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFI 289

                          90
                  ....*....|....*.
gi 1253007271 323 RAFKRWSGRSPSNWRK 338
Cdd:PRK15185  290 QCFKKYFKTTPSTFIK 305
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
91-338 1.88e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 1.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271  91 YAIMTAHEISDALILANRFIQLRMPFLQLFFSTFGEKASLQLQCDIHMEPLRTEIAIALIIGMITMSKAMTGTEHFTGEV 170
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 171 DFDFPKPAGFDQYFAKFPYHQFRFDQPYLGLSFDKQYLGLKMINADPIASQIAINQCEAELSALGERRRISMRVRDILTH 250
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 251 AEQhyLSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWS 329
Cdd:COG2207   166 LLL--LTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRF 243


                  ....*....
gi 1253007271 330 GRSPSNWRK 338
Cdd:COG2207   244 GVTPSEYRK 252
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
256-337 4.31e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 93.77  E-value: 4.31e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271  256 LSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWSGRSPS 334
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 1253007271  335 NWR 337
Cdd:smart00342  82 EYR 84
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 28-212 1.80e-21

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 90.01  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271  28 GYNADTLFAPFQLNSEMLADPECRIPTPIANELVKHALKLTGESTLGYHLGTQMRISIHGFIGYAIMTAHEISDALILAN 107
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 108 RFIQLRMPFLQL-FFSTFGEKASLQLQCDIHMEPLRTEIAIALIIGMITMSKAMTGTEHFTGEVDFDFPKPAGFDQYFAK 186
Cdd:pfam12625  81 RYLRLLSDALELrLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*.
gi 1253007271 187 FPYHqFRFDQPYLGLSFDKQYLGLKM 212
Cdd:pfam12625 161 FGCP-VRFGAPRNALVFDAADLDRPL 185
HTH_18 pfam12833
Helix-turn-helix domain;
261-338 1.12e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.56  E-value: 1.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 261 VADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSR-TDYTLEQIADELGYSDVANFSRAFKRWSGRSPSNWRK 338
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 243-338 9.42e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 88.29  E-value: 9.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 243 RVRDILTHAEQHY---LSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDV 318
Cdd:COG4977   211 RLARAQAWMEANLeepLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSA 290

                          90       100
                  ....*....|....*....|
gi 1253007271 319 ANFSRAFKRWSGRSPSNWRK 338
Cdd:COG4977   291 SHFRRAFRRRFGVSPSAYRR 310
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 243-338 4.31e-12

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 65.79  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 243 RVRDILTHAEQHYLSIENVADYLHMSDRTLKRQLAAEGTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFS 322
Cdd:PRK15185  210 RVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFI 289

                          90
                  ....*....|....*.
gi 1253007271 323 RAFKRWSGRSPSNWRK 338
Cdd:PRK15185  290 QCFKKYFKTTPSTFIK 305
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 240-339 6.29e-11

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 62.03  E-value: 6.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 240 ISMRVRDILTHAEQHYLSIENVADYLHMSDRTLKRQLAAEGTSFSNLVDEVRYRHATSLLsRTDYTLEQIADELGYSDVA 319
Cdd:PRK09940  135 VSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLI-RVEGSVNKIAEQCGYASTS 213

                          90       100
                  ....*....|....*....|
gi 1253007271 320 NFSRAFKRWSGRSPSNWRKD 339
Cdd:PRK09940  214 YFIYAFRKHFGNSPKRVSKE 233
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 240-337 4.57e-09

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 56.47  E-value: 4.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 240 ISMRVRDILTHAEQHYLSIENVADYLHMSDRTLKRQLAAEGTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVA 319
Cdd:PRK09978  143 MRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVS 222

                          90
                  ....*....|....*...
gi 1253007271 320 NFSRAFKRWSGRSPSNWR 337
Cdd:PRK09978  223 YFIYVFRNYYGMTPTEYQ 240
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 257-336 1.33e-08

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 55.46  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 257 SIENVADYLHMSDRTLKRQLAAEGTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWSGRSPSNW 336
Cdd:PRK15186  199 ALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 247-338 3.94e-08

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 53.88  E-value: 3.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 247 ILTHAEQHYLSIENVADYLHMSDRTLKRQLAAEGTSFSNLVDEVRY-RHATSLLSRT-DYTLEQIADELGYSDVANFSRA 324
Cdd:PRK09685  206 IDQSIQEEILRPEWIAGELGISVRSLYRLFAEQGLVVAQYIRNRRLdRCADDLRPAAdDEKITSIAYKWGFSDSSHFSTA 285

                          90
                  ....*....|....
gi 1253007271 325 FKRWSGRSPSNWRK 338
Cdd:PRK09685  286 FKQRFGVSPGEYRR 299
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
216-338 5.69e-08

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 53.44  E-value: 5.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 216 DPIASQIAINQCEA------ELSALGERRRISMRVRD----ILTHAEQHyLSIENVADYLHMSDRTL----KRQLaaeGT 281
Cdd:PRK10572  151 GRYSELLAMNLLERlllrcmEAIPESLHPPMDPRVREacqyISDHLASE-FDIESVAQHVCLSPSRLahlfRQQL---GI 226

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1253007271 282 SFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWSGRSPSNWRK 338
Cdd:PRK10572  227 SVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRA 283
ftrA PRK09393
transcriptional activator FtrA; Provisional
 236-338 3.25e-07

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 51.12  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 236 ERRRISM---RVRDILthAEQHylSIENVADYLHMSDRTLKRQL-AAEGTSFSN-LVDEvRYRHATSLLSRTDYTLEQIA 310
Cdd:PRK09393  216 ESDRLGPlidWMRAHL--AEPH--TVASLAARAAMSPRTFLRRFeAATGMTPAEwLLRE-RLARARDLLESSALSIDQIA 290

                          90       100
                  ....*....|....*....|....*...
gi 1253007271 311 DELGYSDVANFSRAFKRWSGRSPSNWRK 338
Cdd:PRK09393  291 ERAGFGSEESLRHHFRRRAATSPAAYRK 318
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 302-338 1.91e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 44.07  E-value: 1.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1253007271 302 TDYTLEQIADELGYSdVANFSRAFKRWSGRSPSNWRK 338
Cdd:pfam00165   7 TNLTIADIADELGFS-RSYFSRLFKKYTGVTPSQYRH 42
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
268-337 2.68e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 48.13  E-value: 2.68e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1253007271 268 SDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWSGRSPSNWR 337
Cdd:PRK13502  205 SERVLRQQFRAQtGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 227-338 3.06e-06

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 48.51  E-value: 3.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 227 CEAELSALGERRRISMR--VRDILTHAEQHyLSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLsRTD 303
Cdd:COG2169    71 CRPDLAPGSPPRADLVAraCRLIEAGAEDR-PSLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLL-QTG 148

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1253007271 304 YTLEQIADELGYSDVANFSRAFKRWSGRSPSNWRK 338
Cdd:COG2169   149 LSVTDAAYAAGFGSLSRFYEAFKKLLGMTPSAYRR 183
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
256-337 3.51e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 48.17  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 256 LSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWSGRSPS 334
Cdd:PRK13500  223 FALDKFCDEASCSERVLRQQFRQQtGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPS 302


                  ...
gi 1253007271 335 NWR 337
Cdd:PRK13500  303 QWR 305
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
246-338 5.55e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 44.12  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 246 DILTHAEQHYLSIE-NVADYLH---MSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVAN 320
Cdd:PRK13501  179 DLIMSALQQSLGAYfDMADFCHknqLVERSLKQLFRQQtGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNY 258

                          90
                  ....*....|....*...
gi 1253007271 321 FSRAFKRWSGRSPSNWRK 338
Cdd:PRK13501  259 FSAVFTREAGMTPRDYRQ 276
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
243-337 7.49e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 43.90  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 243 RVRDILTHAEQHY---LSIENVADYLHMSDRTLKRQLAAE-GTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDV 318
Cdd:PRK13503  172 RLNQLLAWLEDHFaeeVNWEALADQFSLSLRTLHRQLKQQtGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDS 251

                          90
                  ....*....|....*....
gi 1253007271 319 ANFSRAFKRWSGRSPSNWR 337
Cdd:PRK13503  252 NHFSTLFRREFSWSPRDIR 270
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 261-327 2.32e-04

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 42.33  E-value: 2.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1253007271 261 VADYLHMSDRTLKRQLAAEGTSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKR 327
Cdd:PRK15044  214 VAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKR 280
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 286-338 3.93e-04

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 41.67  E-value: 3.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1253007271 286 LVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRWSGRSPSNWRK 338
Cdd:PRK10296  220 IINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRK 272
PRK10371 PRK10371
transcriptional regulator MelR;
231-338 5.23e-04

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 41.34  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 231 LSALGERRRISMRVRDILTHAEQHY---LSIENVADYL----HMSDRTLKRqlaAEGTSFSNLVDEVRYRHATSLLSRTD 303
Cdd:PRK10371  180 THKNSVSRHAQFYVSQMLGFIAENYdqaLTINDVAEHVklnaNYAMGIFQR---VMQLTMKQYITAMRINHVRALLSDTD 256

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1253007271 304 YTLEQIADELGYSDVANFSRAFKRWSGRSPSNWRK 338
Cdd:PRK10371  257 KSILDIALTAGFRSSSRFYSTFGKYVGMSPQQYRK 291
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
303-339 6.29e-04

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 38.30  E-value: 6.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1253007271  303 DYTLEQIADELGYSdVANFSRAFKRWSGRSPSNWRKD 339
Cdd:smart00342   1 PLTLEDLAEALGVS-PRHLQRLFKKETGTTPKQYLRD 36
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
137-339 4.00e-03

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 38.61  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 137 HMEPLRTEIAIALIIGMITMSKAMTGTEHFTGEVDFDFPKPAGFDQYFAKFPYHQFRFDQPYLGLSFDKQYLGLKMINAD 216
Cdd:COG2207     3 LLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 217 PIASQIAINQCEAELSALGERRRISMRVRDILTHAEQHYLSIENVADYLHMSDRTLKRQLAAEGTSFSNLVDEVRYRHAT 296
Cdd:COG2207    83 LALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLL 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1253007271 297 SLLSRTdYTLEQIADELGYSdVANFSRAFKRWSGRSPSNWRKD 339
Cdd:COG2207   163 LLLLLL-LTLEELARELGLS-PRTLSRLFKEETGTSPKQYLRE 203
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
256-337 7.96e-03

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 35.67  E-value: 7.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253007271 256 LSIENVAD-------YLHMSDRTLKRQlaaegtSFSNLVDEVRYRHATSLLSRTDYTLEQIADELGYSDVANFSRAFKRW 328
Cdd:PRK10219   22 LNIDVVAKksgyskwYLQRMFRTVTHQ------TLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQ 95


                  ....*....
gi 1253007271 329 SGRSPSNWR 337
Cdd:PRK10219   96 FDRTPSDYR 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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