|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
80-382 |
7.56e-67 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 214.81 E-value: 7.56e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 80 VKQGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVALRSA--------- 150
Cdd:COG0845 3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAqaqlelaka 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 151 -VEKSSSYSNLKSVSRLDVLD-------AQIAEEAAKLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQSTIVGI 222
Cdd:COG0845 83 eLERYKALLKKGAVSQQELDQakaaldqAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGTPLFTI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 223 DDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSfgVTMR 302
Cdd:COG0845 163 ADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMF--VRVR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 303 FAGETYAS---VDPLAVQWDSEGSYVWRVTDNKSAKVR-VQIVQRNPDAVLVKAELAEGDQVVTEGLQRVREGGAVRVAS 378
Cdd:COG0845 241 IVLGERENallVPASAVVRDGGGAYVFVVDADGKVERRpVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKVRVVE 320
|
....
gi 1254170055 379 QPKP 382
Cdd:COG0845 321 AAAP 324
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
75-376 |
1.05e-60 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 198.69 E-value: 1.05e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 75 VAMAPVKQGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVALRSA---- 150
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAeaql 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 151 ------VEKSSSYSNLKSVSRLDVLDAQIAEEAA-------KLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQS 217
Cdd:TIGR01730 81 elaqrsFERAERLVKRNAVSQADLDDAKAAVEAAqadleaaKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 218 TIVGIDDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSF 297
Cdd:TIGR01730 161 TLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 298 GVTMRFAGETYA-SVDPLAVQWDSEGSYVWRV-TDNKSAKVRVQIVQRNPDAVLVKAELAEGDQVVTEGLQRVREGGAVR 375
Cdd:TIGR01730 241 RVTISLKVRSSAiVVPTQAVIEDLNGKYVYVVkNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRDGAKVK 320
|
.
gi 1254170055 376 V 376
Cdd:TIGR01730 321 V 321
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
2-388 |
4.40e-31 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 122.59 E-value: 4.40e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 2 RVWKQVGVCLAVAGAglcLWGFYSpearnllagigIGKTPAGAVEVAASGARTPGSSpgqnaGAARRDGNATLVAMAPVK 81
Cdd:PRK11556 8 RWVIVIVVVIAAIAA---FWFWQG-----------RSTSSSAAPGAAKQAQQSPAGG-----RRGMRSGPLAPVQAATAT 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 82 QGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEE-QV--------IERDKAQVA-LRSAV 151
Cdd:PRK11556 69 EQAVPRYLTGLGTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPfKValaqaqgqLAKDQATLAnARRDL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 152 EKSSSYSNLKSVSRLDvLDAQIAE--------EAAKLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQST--IVG 221
Cdd:PRK11556 149 ARYQQLAKTNLVSRQE-LDAQQALvsetegtiKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTtgIVV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 222 IDDRSQILVNFWAPER-FATAITV-----GMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGM 295
Cdd:PRK11556 228 ITQTHPIDLVFTLPESdIATVVQAqkagkPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQ 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 296 SFGVTMRFAGETYASVDP-LAVQWDSEGSYVWRVTD-NKSAKVRVQIVQRNPDAVLVKAELAEGDQVVTEGLQRVREGGA 373
Cdd:PRK11556 308 FVNARMLVDTLQNAVVIPtAALQMGNEGHFVWVLNDeNKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAK 387
|
410 420
....*....|....*....|..
gi 1254170055 374 VRV-------ASQPKPEEVASQ 388
Cdd:PRK11556 388 VEVvepqsatTPEEKATSREYA 409
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
101-295 |
4.46e-21 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 90.26 E-value: 4.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 101 VVVMPQTSGTLSEIRISS-GARVVKGQVLARLDDEEQVierdKAQVALRSAVE--KSSSYSNLKSVSR-----LDVLDAQ 172
Cdd:pfam16576 20 AHVHARVEGWIEKLYVNAtGDPVKKGQPLAELYSPELV----AAQQEYLLALRsgDALSKSELLRAARqrlrlLGMPEAQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 173 IAE-EAAKLALSTAElnlrrrdIVAPIEGVVGIVAANIGDNVTTQSTIVGIDDRSQILVNFWAPERFATAITVGMPVEAT 251
Cdd:pfam16576 96 IAElERTGKVQPTVT-------VYAPISGVVTELNVREGMYVQPGDTLFTIADLSTVWVEADVPEQDLALVKVGQPAEVT 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1254170055 252 SISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGM 295
Cdd:pfam16576 169 LPALPGKTFEGKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGM 212
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
80-382 |
7.56e-67 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 214.81 E-value: 7.56e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 80 VKQGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVALRSA--------- 150
Cdd:COG0845 3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAqaqlelaka 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 151 -VEKSSSYSNLKSVSRLDVLD-------AQIAEEAAKLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQSTIVGI 222
Cdd:COG0845 83 eLERYKALLKKGAVSQQELDQakaaldqAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGTPLFTI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 223 DDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSfgVTMR 302
Cdd:COG0845 163 ADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMF--VRVR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 303 FAGETYAS---VDPLAVQWDSEGSYVWRVTDNKSAKVR-VQIVQRNPDAVLVKAELAEGDQVVTEGLQRVREGGAVRVAS 378
Cdd:COG0845 241 IVLGERENallVPASAVVRDGGGAYVFVVDADGKVERRpVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKVRVVE 320
|
....
gi 1254170055 379 QPKP 382
Cdd:COG0845 321 AAAP 324
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
75-376 |
1.05e-60 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 198.69 E-value: 1.05e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 75 VAMAPVKQGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVALRSA---- 150
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAeaql 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 151 ------VEKSSSYSNLKSVSRLDVLDAQIAEEAA-------KLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQS 217
Cdd:TIGR01730 81 elaqrsFERAERLVKRNAVSQADLDDAKAAVEAAqadleaaKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 218 TIVGIDDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSF 297
Cdd:TIGR01730 161 TLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 298 GVTMRFAGETYA-SVDPLAVQWDSEGSYVWRV-TDNKSAKVRVQIVQRNPDAVLVKAELAEGDQVVTEGLQRVREGGAVR 375
Cdd:TIGR01730 241 RVTISLKVRSSAiVVPTQAVIEDLNGKYVYVVkNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRDGAKVK 320
|
.
gi 1254170055 376 V 376
Cdd:TIGR01730 321 V 321
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
2-388 |
4.40e-31 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 122.59 E-value: 4.40e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 2 RVWKQVGVCLAVAGAglcLWGFYSpearnllagigIGKTPAGAVEVAASGARTPGSSpgqnaGAARRDGNATLVAMAPVK 81
Cdd:PRK11556 8 RWVIVIVVVIAAIAA---FWFWQG-----------RSTSSSAAPGAAKQAQQSPAGG-----RRGMRSGPLAPVQAATAT 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 82 QGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEE-QV--------IERDKAQVA-LRSAV 151
Cdd:PRK11556 69 EQAVPRYLTGLGTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPfKValaqaqgqLAKDQATLAnARRDL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 152 EKSSSYSNLKSVSRLDvLDAQIAE--------EAAKLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQST--IVG 221
Cdd:PRK11556 149 ARYQQLAKTNLVSRQE-LDAQQALvsetegtiKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTtgIVV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 222 IDDRSQILVNFWAPER-FATAITV-----GMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGM 295
Cdd:PRK11556 228 ITQTHPIDLVFTLPESdIATVVQAqkagkPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQ 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 296 SFGVTMRFAGETYASVDP-LAVQWDSEGSYVWRVTD-NKSAKVRVQIVQRNPDAVLVKAELAEGDQVVTEGLQRVREGGA 373
Cdd:PRK11556 308 FVNARMLVDTLQNAVVIPtAALQMGNEGHFVWVLNDeNKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAK 387
|
410 420
....*....|....*....|..
gi 1254170055 374 VRV-------ASQPKPEEVASQ 388
Cdd:PRK11556 388 VEVvepqsatTPEEKATSREYA 409
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
101-295 |
4.46e-21 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 90.26 E-value: 4.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 101 VVVMPQTSGTLSEIRISS-GARVVKGQVLARLDDEEQVierdKAQVALRSAVE--KSSSYSNLKSVSR-----LDVLDAQ 172
Cdd:pfam16576 20 AHVHARVEGWIEKLYVNAtGDPVKKGQPLAELYSPELV----AAQQEYLLALRsgDALSKSELLRAARqrlrlLGMPEAQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 173 IAE-EAAKLALSTAElnlrrrdIVAPIEGVVGIVAANIGDNVTTQSTIVGIDDRSQILVNFWAPERFATAITVGMPVEAT 251
Cdd:pfam16576 96 IAElERTGKVQPTVT-------VYAPISGVVTELNVREGMYVQPGDTLFTIADLSTVWVEADVPEQDLALVKVGQPAEVT 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1254170055 252 SISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGM 295
Cdd:pfam16576 169 LPALPGKTFEGKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGM 212
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
99-296 |
4.34e-20 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 90.11 E-value: 4.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 99 QSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVALRSAV--------------EKSSSYSNLKS-- 162
Cdd:COG1566 44 RVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQLAAAEaqlarleaelgaeaEIAAAEAQLAAaq 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 163 ---------------------VSRLDVLDAQIAEEAAKLALS----------------------------------TAEL 187
Cdd:COG1566 124 aqldlaqreleryqalykkgaVSQQELDEARAALDAAQAQLEaaqaqlaqaqaglreeeelaaaqaqvaqaeaalaQAEL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 188 NLRRRDIVAPIEGVVGIVAANIGDNVTTQSTIVGIDDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGEVEAV 267
Cdd:COG1566 204 NLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVPLDDLWVEAYVPETDLGRVKPGQPVEVRVDAYPDRVFEGKVTSI 283
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1254170055 268 DNRVDAAS----------RTIRIRARFAN-DKDELRAGMS 296
Cdd:COG1566 284 SPGAGFTSppknatgnvvQRYPVRIRLDNpDPEPLRPGMS 323
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
79-362 |
1.36e-12 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 68.26 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 79 PVKQGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEE---QVIE-----------RDKAQ 144
Cdd:PRK11578 40 IVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQaenQIKEveatlmelraqRQQAE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 145 VALRSA---VEKSSSYSNLKSVSRLDV----------------LDAQIAEEAAklALSTAELNLRRRDIVAPIEGVVGIV 205
Cdd:PRK11578 120 AELKLArvtLSRQQRLAKTQAVSQQDLdtaatelavkqaqigtIDAQIKRNQA--SLDTAKTNLDYTRIVAPMAGEVTQI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 206 AANIGDNVTTQS---TIVGIDDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRA 282
Cdd:PRK11578 198 TTLQGQTVIAAQqapNILTLADMSTMLVKAQVSEADVIHLKPGQKAWFTVLGDPLTRYEGVLKDILPTPEKVNDAIFYYA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 283 RF--ANDKDELRAGMSFGVTMRFAGETYASVDPLAVQWDSEGSYVWRVT---DNKSAKVRVQIVQRNPDAVLVKAELAEG 357
Cdd:PRK11578 278 RFevPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGDNRYKVKllrNGETREREVTIGARNDTDVEIVKGLEAG 357
|
....*
gi 1254170055 358 DQVVT 362
Cdd:PRK11578 358 DEVII 362
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
99-362 |
7.13e-11 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 62.83 E-value: 7.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 99 QSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVALRSA----------VEKSSSYSNLKSVSRLDV 168
Cdd:pfam00529 19 NAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAqaqvarlqaeLDRLQALESELAISRQDY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 169 LD-------AQIAEEAAKLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQSTIVG--IDDRSQILVNFWAPERFA 239
Cdd:pfam00529 99 DGataqlraAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLatVAQLDQIYVQITQSAAEN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 240 TAITVGMPVEATSISRPGET-----------------FKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSFGVTMR 302
Cdd:pfam00529 179 QAEVRSELSGAQLQIAEAEAelklakldlerteirapVDGTVAFLSVTVDGGTVSAGLRLMFVVPEDNLLVPGMFVETQL 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254170055 303 FAGETYASVD--PLAVQWDSEGSYVWRVT--DNKSAKVRVQIVQRNPDAVLVKAELAEGDQVVT 362
Cdd:pfam00529 259 DQVRVGQPVLipFDAFPQTKTGRFTGVVVgiSPDTGPVRVVVDKAQGPYYPLRIGLSAGALVRL 322
|
|
| PRK09783 |
PRK09783 |
copper/silver efflux system membrane fusion protein CusB; Provisional |
75-365 |
4.94e-09 |
|
copper/silver efflux system membrane fusion protein CusB; Provisional
Pssm-ID: 236625 [Multi-domain] Cd Length: 409 Bit Score: 57.57 E-value: 4.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 75 VAMAPVKQGTVND--RLNAIGSGEAIQSVVVMPQTSGTLSEIR-ISSGARVVKGQVLARLDDEEQViERDKAQVALRSAV 151
Cdd:PRK09783 96 VKTATVTRGPLTFaqTFPANVSYNEYQYAIVQARAAGFIDKVYpLTVGDKVQKGTPLLDLTIPDWV-EAQSEYLLLRETG 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 152 EKSSSYSNLKSVSRLdvldAQIAEEAAKLALSTAELNlRRRDIVAPIEGVVGIVAANIGDNVTTQSTIVGIDDRSQILVN 231
Cdd:PRK09783 175 GTATQTEGILERLRL----AGMPEADIRRLIATRKIQ-TRFTLKAPIDGVITAFDLRAGMNIAKDNVVAKIQGMDPVWVT 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 232 FWAPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSFGVTMRFAGE----- 306
Cdd:PRK09783 250 AAIPESIAWLVKDASQFTLTVPARPDKTFTIRKWTLLPSVDAATRTLQLRLEVDNADEALKPGMNAWLQLNTASEpmlli 329
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254170055 307 -TYASVDPLAVQW----DSEGSYVWRvtdnksakvRVQIVQRNPDAVLVKAELAEGDQVVTEGL 365
Cdd:PRK09783 330 pSQALIDTGSEQRvitvDADGRFVPK---------RVAVFQESQGVTAIRSGLAEGEKVVSSGL 384
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
59-387 |
2.40e-08 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 55.49 E-value: 2.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 59 PGQNAGAARRDgnatlVAMAPVKQGTVNDRLNAIGSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVI 138
Cdd:PRK09859 25 SAENAAAMTPE-----VGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 139 ERDKAQVALRSAVEKSSS------------YSNLKSVSRLDVLDAQIAE-EA----AKLALSTAELNLRRRDIVAPIEGV 201
Cdd:PRK09859 100 ELNSAKGSLAKALSTASNaritfnrqasllKTNYVSRQDYDTARTQLNEaEAnvtvAKAAVEQATINLQYANVTSPITGV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 202 VGIVAANIGDNVTTQS-----TIVGID----DRSQILVNFWapeRFATAITVGM--------PVEATSISRPGETFKGEV 264
Cdd:PRK09859 180 SGKSSVTVGALVTANQadslvTVQRLDpiyvDLTQSVQDFL---RMKEEVASGQikqvqgstPVQLNLENGKRYSQTGTL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 265 EAVDNRVDAASRTIRIRARFANDKDELRAGMSFGVTMRFAGETYASVDPL-AVQWDSEGSYVWRVTD-NKSAKVR-VQIV 341
Cdd:PRK09859 257 KFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQeGVTHNAQGKATALILDkDDVVQLReIEAS 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1254170055 342 QRNPDAVLVKAELAEGDQVVTEGLQRVREGGAVRVASQpkPEEVAS 387
Cdd:PRK09859 337 KAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISS--SQENAS 380
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
194-294 |
2.45e-08 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 51.59 E-value: 2.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 194 IVAPIEGVVGIVAANIGDNVTTQSTIVGIDDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDA 273
Cdd:pfam13437 2 IRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYTLEGKVVRISPTVDP 81
|
90 100
....*....|....*....|...
gi 1254170055 274 ASRTIRIRARFANDKDE--LRAG 294
Cdd:pfam13437 82 DTGVIPVRVSIENPKTPipLLPG 104
|
|
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
93-376 |
7.45e-07 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 50.87 E-value: 7.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 93 GSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERD-------KAQVALRSAVEKSSSYSNL---KS 162
Cdd:PRK15030 58 GRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDsakgdlaKAQAAANIAQLTVNRYQKLlgtQY 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 163 VSRLD----VLDAQIAEE---AAKLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNV-----TTQSTIVGID----DRS 226
Cdd:PRK15030 138 ISKQEydqaLADAQQANAavtAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVqngqaTALATVQQLDpiyvDVT 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 227 QILVNFWapeRFATAITVGM------PVEATSISRPGETF--KGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSFG 298
Cdd:PRK15030 218 QSSNDFL---RLKQELANGTlkqengKAKVSLITSDGIKFpqDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 299 VTMRFAGETYASVDPL-AVQWDSEGSYVWRV--TDNKSAKVRVQIVQRNPDAVLVKAELAEGDQVVTEGLQRVREGGAVR 375
Cdd:PRK15030 295 ARLEEGLNPNAILVPQqGVTRTPRGDATVLVvgADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVK 374
|
.
gi 1254170055 376 V 376
Cdd:PRK15030 375 A 375
|
|
| PRK03598 |
PRK03598 |
putative efflux pump membrane fusion protein; Provisional |
140-307 |
1.54e-06 |
|
putative efflux pump membrane fusion protein; Provisional
Pssm-ID: 235136 [Multi-domain] Cd Length: 331 Bit Score: 49.58 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 140 RDKAQVALRSAVEKSSSYSNLKSVSRLDVLDAQIAeeAAKLALSTAELNLRRRDIVAPIEGVVGIVAANIGDNVTTQSTI 219
Cdd:PRK03598 154 RDQAQATLKSAQDKLSQYREGNRPQDIAQAKASLA--QAQAALAQAELNLQDTELIAPSDGTILTRAVEPGTMLNAGSTV 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 220 VGIDDRSQILVNFWAPERFATAITVGMPVEATSISRPGETFKGE--------------VEAVDNRVDAASRtIRIrarFA 285
Cdd:PRK03598 232 FTLSLTRPVWVRAYVDERNLGQAQPGRKVLLYTDGRPDKPYHGQigfvsptaeftpktVETPDLRTDLVYR-LRI---VV 307
|
170 180
....*....|....*....|...
gi 1254170055 286 NDKDE-LRAGMSfgVTMRFAGET 307
Cdd:PRK03598 308 TDADDaLRQGMP--VTVRFADEA 328
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
93-388 |
6.25e-06 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 47.87 E-value: 6.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 93 GSGEAIQSVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVAL-------RSAVEKSSSYSNL---KS 162
Cdd:PRK09578 56 GRLDAYRQAEVRARVAGIVTARTYEEGQEVKQGAVLFRIDPAPLKAARDAAAGALakaeaahLAALDKRRRYDDLvrdRA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 163 VSRLDVLDAQIAEEAAKLALSTAELNLRRRD-------IVAPIEGVV--GIV--AANIG-DNVTTQSTIVGIDdrsQILV 230
Cdd:PRK09578 136 VSERDYTEAVADERQAKAAVASAKAELARAQlqldyatVTAPIDGRArrALVteGALVGqDQATPLTTVEQLD---PIYV 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 231 NFWAP----ERFATAITVGM-------PVEATSISRPGETF--KGEVEAVDNRVDAASRTIRIRARFANDKDELRAGMSF 297
Cdd:PRK09578 213 NFSQPaadvEALRRAVKSGRatgiaqqDVAVTLVRADGSEYplKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYV 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 298 GVTMRFAGETYASVDPLAVQWDSEGSYVWRVTDNKSAKVRVQIV---QRNPDAVLVKAeLAEGDQVVTEGLQRVREGGAV 374
Cdd:PRK09578 293 RIALDRAVNPRAILVPRDALLRTADSASVKVVGQNGKVRDVEVEadqMSGRDWIVTRG-LAGGERVIVDNAAQFAPGTAV 371
|
330
....*....|....
gi 1254170055 375 RVASQPKPEEVASQ 388
Cdd:PRK09578 372 KAVERAPAAKPAPG 385
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
100-148 |
1.15e-04 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 39.35 E-value: 1.15e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1254170055 100 SVVVMPQTSGTLSEIRISSGARVVKGQVLARLDDEEQVIERDKAQVALR 148
Cdd:pfam13533 2 VVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQLA 50
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
124-282 |
1.62e-04 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 43.48 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 124 KGQVLARLDDEEQVIERDkAQVALRSAVEKSSSYSNLksVSRLDVLDAQIAEEAAKLALstAELNLRRRDIVAPIEGVVG 203
Cdd:PRK10476 146 KGYVSAQQVDQARTAQRD-AEVSLNQALLQAQAAAAA--VGGVDALVAQRAAREAALAI--AELHLEDTTVRAPFDGRVV 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 204 IVAANIGDNVT-TQSTIVGIDDRSQILV-NFwaPERFATAITVGMPVEATSISRPGETFKGEVEAVDNRVDAASRTIRIR 281
Cdd:PRK10476 221 GLKVSVGEFAApMQPIFTLIDTDHWYAIaNF--RETDLKNIRVGDCATVYSMIDRGRPFEGKVDSIGWGVLPDDGGNVPR 298
|
.
gi 1254170055 282 A 282
Cdd:PRK10476 299 G 299
|
|
| PRK15136 |
PRK15136 |
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA; |
90-194 |
4.27e-03 |
|
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
Pssm-ID: 185090 [Multi-domain] Cd Length: 390 Bit Score: 38.91 E-value: 4.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254170055 90 NAIGSGEAIQsvvVMPQTSGTLSEIRISSGARVVKGQVLARLD--DEEQVIErdKAQVALRSAVEKSSSysnlksvSRLD 167
Cdd:PRK15136 54 DAYVAGNQVQ---IMSQVSGSVTKVWADNTDFVKEGDVLVTLDptDAEQAFE--KAKTALANSVRQTHQ-------LMIN 121
|
90 100
....*....|....*....|....*..
gi 1254170055 168 VLDAQIAEEAAKLALSTAELNLRRRDI 194
Cdd:PRK15136 122 SKQYQANIELQKTALAQAQSDLNRRVP 148
|
|
| |
