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Conserved domains on  [gi|1255645395|ref|WP_097464526.1|]
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conjugal transfer protein TraL

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 4-161 4.66e-59

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd05386:

Pssm-ID: 476819  Cd Length: 155  Bit Score: 184.08  E-value: 4.66e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255645395   4 SINFVLQGKGGVGKSFISSMLSQYFMDqKAIPLIVADTDPVNSTTAKVSRLNAGVIKIVENNTIVQSRFDKMFESILSDg 83
Cdd:cd05386     1 KIHFVLQGKGGVGKSVIASLLAQYLID-KGQPVSCIDTDPVNKTFAGYKALNVQRINIIDNDEIIQSKFDQLVEQFLAE- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1255645395  84 NKTFVIDNGASTFLPLLQYFADNCVMEMFDDVDQDVYIHTIIVGGQAQADTLEGFESIKELVKNtNVKIVVWFNEFQG 161
Cdd:cd05386    79 DGTVVIDTGASTFLPLMNYLIDNDVPDLLKDMGKEVVIHTVINGGQALDDTINGLQTLLDQFKD-NAKVVVWLNEYFG 155
 
Name Accession Description Interval E-value
TraL cd05386
transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI ...
 4-161 4.66e-59

transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI superfamily which contains a ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion. The specific function of TraL protein is unknown.


Pssm-ID: 349771  Cd Length: 155  Bit Score: 184.08  E-value: 4.66e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255645395   4 SINFVLQGKGGVGKSFISSMLSQYFMDqKAIPLIVADTDPVNSTTAKVSRLNAGVIKIVENNTIVQSRFDKMFESILSDg 83
Cdd:cd05386     1 KIHFVLQGKGGVGKSVIASLLAQYLID-KGQPVSCIDTDPVNKTFAGYKALNVQRINIIDNDEIIQSKFDQLVEQFLAE- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1255645395  84 NKTFVIDNGASTFLPLLQYFADNCVMEMFDDVDQDVYIHTIIVGGQAQADTLEGFESIKELVKNtNVKIVVWFNEFQG 161
Cdd:cd05386    79 DGTVVIDTGASTFLPLMNYLIDNDVPDLLKDMGKEVVIHTVINGGQALDDTINGLQTLLDQFKD-NAKVVVWLNEYFG 155
PRK13886 PRK13886
conjugal transfer protein TraL; Provisional
 5-240 7.80e-50

conjugal transfer protein TraL; Provisional


Pssm-ID: 184370  Cd Length: 241  Bit Score: 163.36  E-value: 7.80e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255645395   5 INFVLQGKGGVGKSFISSMLSQYFMDQKAIPLIVaDTDPVNSTTAKVSRLNAGVIKIVENNTIVQSRFDKMFESILSDGN 84
Cdd:PRK13886    4 IHMVLQGKGGVGKSFIAATIAQYKASKGQKPLCI-DTDPVNATFEGYKALNVRRLNIMDGDEINTRNFDALVEMIASTEG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255645395  85 KTfVIDNGASTFLPLLQYFADNCVMEMFDDVDQDVYIHTIIVGGQAQADTLEGFEsikELVKN--TNVKIVVWFNEFQGI 162
Cdd:PRK13886   83 DV-IIDNGASSFVPLSHYLISNQVPALLQDMGHELVVHTVVTGGQALLDTVSGFA---QLASQfpAECLFVVWLNPYWGP 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1255645395 163 PALNGKNIIETNFLQKNIDYVSGAVLIKDRKSDAYDSDIKKLSSESLTLVEALESDSFGLMAKSRLKRVFNDVYTQLD 240
Cdd:PRK13886  159 IEHEGKGFEQMKAYTANKDRVSAIIQIPALKEETYGRDFSEMLQDRLTFDEALADSSLTIMTRQRLKIVKDQLFAQLD 236
CooC COG3640
CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, ...
 11-43 9.53e-05

CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442857 [Multi-domain]  Cd Length: 249  Bit Score: 42.46  E-value: 9.53e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1255645395  11 GKGGVGKSFISSMLSQYFMDQKAiPLIVADTDP 43
Cdd:COG3640     7 GKGGVGKTTLSALLARYLAEKGK-PVLAVDADP 38
 
Name Accession Description Interval E-value
TraL cd05386
transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI ...
 4-161 4.66e-59

transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI superfamily which contains a ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion. The specific function of TraL protein is unknown.


Pssm-ID: 349771  Cd Length: 155  Bit Score: 184.08  E-value: 4.66e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255645395   4 SINFVLQGKGGVGKSFISSMLSQYFMDqKAIPLIVADTDPVNSTTAKVSRLNAGVIKIVENNTIVQSRFDKMFESILSDg 83
Cdd:cd05386     1 KIHFVLQGKGGVGKSVIASLLAQYLID-KGQPVSCIDTDPVNKTFAGYKALNVQRINIIDNDEIIQSKFDQLVEQFLAE- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1255645395  84 NKTFVIDNGASTFLPLLQYFADNCVMEMFDDVDQDVYIHTIIVGGQAQADTLEGFESIKELVKNtNVKIVVWFNEFQG 161
Cdd:cd05386    79 DGTVVIDTGASTFLPLMNYLIDNDVPDLLKDMGKEVVIHTVINGGQALDDTINGLQTLLDQFKD-NAKVVVWLNEYFG 155
PRK13886 PRK13886
conjugal transfer protein TraL; Provisional
 5-240 7.80e-50

conjugal transfer protein TraL; Provisional


Pssm-ID: 184370  Cd Length: 241  Bit Score: 163.36  E-value: 7.80e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255645395   5 INFVLQGKGGVGKSFISSMLSQYFMDQKAIPLIVaDTDPVNSTTAKVSRLNAGVIKIVENNTIVQSRFDKMFESILSDGN 84
Cdd:PRK13886    4 IHMVLQGKGGVGKSFIAATIAQYKASKGQKPLCI-DTDPVNATFEGYKALNVRRLNIMDGDEINTRNFDALVEMIASTEG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255645395  85 KTfVIDNGASTFLPLLQYFADNCVMEMFDDVDQDVYIHTIIVGGQAQADTLEGFEsikELVKN--TNVKIVVWFNEFQGI 162
Cdd:PRK13886   83 DV-IIDNGASSFVPLSHYLISNQVPALLQDMGHELVVHTVVTGGQALLDTVSGFA---QLASQfpAECLFVVWLNPYWGP 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1255645395 163 PALNGKNIIETNFLQKNIDYVSGAVLIKDRKSDAYDSDIKKLSSESLTLVEALESDSFGLMAKSRLKRVFNDVYTQLD 240
Cdd:PRK13886  159 IEHEGKGFEQMKAYTANKDRVSAIIQIPALKEETYGRDFSEMLQDRLTFDEALADSSLTIMTRQRLKIVKDQLFAQLD 236
CooC COG3640
CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, ...
 11-43 9.53e-05

CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442857 [Multi-domain]  Cd Length: 249  Bit Score: 42.46  E-value: 9.53e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1255645395  11 GKGGVGKSFISSMLSQYFMDQKAiPLIVADTDP 43
Cdd:COG3640     7 GKGGVGKTTLSALLARYLAEKGK-PVLAVDADP 38
CooC1 cd02034
accessory protein CooC1; The accessory protein CooC1, a nickel-binding ATPase, participates in ...
 11-51 2.85e-03

accessory protein CooC1; The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.


Pssm-ID: 349754 [Multi-domain]  Cd Length: 249  Bit Score: 38.06  E-value: 2.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1255645395  11 GKGGVGKSFISSMLSQYFMdQKAIPLIVADTDPvNSTTAKV 51
Cdd:cd02034     7 GKGGVGKTTIAALLIRYLA-KKGGKVLAVDADP-NSNLAET 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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